Minna Kaikkonen-Määttä
Head of Department
Professor
A.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences
minna.kaikkonen@uef.fi | +358 40 355 2413
Minna Kaikkonen-Määttä is a Professor of Cardiovascular Genomics and Director of the Single Cell Genomics Core at University of Eastern Finland. She obtained her Bachelor’s degree in Cellular Biology and Physiology from the Claude Bernard University Lyon 1, France, in 2002 and Master’s degree in Molecular Biology from University of Jyväskylä, Finland, in 2005. She obtained her PhD in Molecular Medicine in 2008. She did her postdoctoral studies at University of California San Diego investigating transcriptional gene regulation and enhancer RNAs (2009-2012) before moving to University of Eastern Finland to establish her own research group. She is the vice head of A.I.Virtanen Institute, President of the Finnish Society of Atherosclerosis and member of the board of European Vascular Biology Organization, Scandinavian Society of Atherosclerosis, and Membership Engagement Committee of the American Society of Human Genetics.
Research groups
Projects
Publications
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Coronary Artery Disease Risk Variant Dampens the Expression of CALCRL by Reducing HSF Binding to Shear Stress Responsive Enhancer in Endothelial Cells in Vitro
Selvarajan, Ilakya; Kiema, Miika; Huang, Ru Ting; Li, Jin; Zhu, Jiayu; Pölönen, Petri; Örd, Tiit; Õunap, Kadri; Godiwala, Mehvash; Golebiewski, Anna Kathryn; Ravindran, Aarthi; Mäklin, Kiira; Toropainen, Anu; Stolze, Lindsey K; Arce, Maximiliano; Magnusson, Peetra U; White, Stephen; Romanoski, Casey E; Heinäniemi, Merja; Laakkonen, Johanna P; Fang, Yun; Kaikkonen, Minna U. 2024. Arteriosclerosis, thrombosis, and vascular biology. 44: 1330-1345 -
Enhancing prediction accuracy of coronary artery disease through machine learning-driven genomic variant selection
Alireza, Z.; Maleeha, M.; Kaikkonen, M.; Fortino, V.. 2024. Journal of translational medicine. 22: . 356 -
Genetic variation drives differences in obesity-related gene regulation
Kaikkonen, Minna U. 2024. Trends in genetics. 40: 296-298 -
Increased secretion of adipocyte-derived extracellular vesicles is associated with adipose tissue inflammation and the mobilization of excess lipid in human obesity
Matilainen, Johanna; Berg, Viivi; Vaittinen, Maija; Impola, Ulla; Mustonen, Anne-Mari; Männistö, Ville; Malinen, Marjo; Luukkonen, Veera; Rosso, Natalia; Turunen, Tanja; Käkelä, Pirjo; Palmisano, Silvia; Arasu, Uma Thanigai; Sihvo, Sanna P.; Aaltonen, Niina; Härkönen, Kai; Caddeo, Andrea; Kaminska, Dorota; Pajukanta, Päivi; Kaikkonen, Minna U.; Tiribelli, Claudio; Käkelä, Reijo; Laitinen, Saara; Pihlajamäki, Jussi; Nieminen, Petteri; Rilla, Kirsi. 2024. Journal of translational medicine. 22: . 623 -
Integrative multi-omics profiling in human decedents receiving pig heart xenografts
Schmauch, Eloi; Piening, Brian; Mohebnasab, Maedeh; Xia, Bo; Zhu, Chenchen; Stern, Jeffrey; Zhang, Weimin; Dowdell, Alexa K.; Kim, Jacqueline I.; Andrijevic, David; Khalil, Karen; Jaffe, Ian S.; Loza, Bao Li; Gragert, Loren; Camellato, Brendan R.; Oliveira, Michelli F.; O’Brien, Darragh P.; Chen, Han M.; Weldon, Elaina; Gao, Hui; Gandla, Divya; Chang, Andrew; Bhatt, Riyana; Gao, Sarah; Lin, Xiangping; Reddy, Kriyana P.; Kagermazova, Larisa; Habara, Alawi H.; Widawsky, Sophie; Liang, Feng Xia; Sa. 2024. Nature medicine. 30: 1448-1460 -
Mechanosensitive super-enhancers regulate genes linked to atherosclerosis in endothelial cells
Li, Jin; Zhu, Jiayu; Gray, Olivia; Sobreira, Debora R; Wu, David; Huang, Ru-Ting; Miao, Bernadette; Sakabe, Noboru J; Krause, Matthew D; Kaikkonen, Minna U; Romanoski, Casey E; Nobrega, Marcelo A; Fang, Yun. 2024. Journal of cell biology. 223: -
Oncogenic KEAP1 mutations activate TRAF2-NFκB signaling to prevent apoptosis in lung cancer cells
Deen, Ashik Jawahar; Adinolfi, Simone; Härkönen, Jouni; Patinen, Tommi; Liu, Xiaonan; Laitinen, Tuomo; Takabe, Piia; Kainulainen, Kirsi; Pasonen-Seppänen, Sanna; Gawriyski, Lisa M; Arasu, Uma Thanigai; Selvarajan, Ilakya; Mäkinen, Petri; Laitinen, Hanna; Kansanen, Emilia; Kaikkonen, Minna U; Poso, Antti; Varjosalo, Markku; Levonen, Anna-Liisa. 2024. Redox biology. 69: -
Progression of herpesvirus infection remodels mitochondrial organization and metabolism
Leclerc, Simon; Gupta, Alka; Ruokolainen, Visa; Chen, Jian Hua; Kunnas, Kari; Ekman, Axel A; Niskanen, Henri; Belevich, Ilya; Vihinen, Helena; Turkki, Paula; Perez-Berna, Ana J; Kapishnikov, Sergey; Mäntylä, Elina; Harkiolaki, Maria; Dufour, Eric; Hytönen, Vesa; Pereiro, Eva; McEnroe, Tony; Fahy, Kenneth; Kaikkonen, Minna U; Jokitalo, Eija; Larabell, Carolyn A; Weinhardt, Venera; Mattola, Salla; Aho, Vesa; Vihinen-Ranta, Maija. 2024. PLoS pathogens. 20: -
Secreted Protein Profiling of Human Aortic Smooth Muscle Cells Identifies Vascular Disease Associations
Aherrahrou, Rédouane; Baig, Ferheen; Theofilatos, Konstantinos; Lue, Dillon; Beele, Alicia; Örd, Tiit; Kaikkonen, Minna U; Aherrahrou, Zouhair; Cheng, Qi; Ghosh, Saikat Kumar B; Karnewar, Santosh; Karnewar, Vaishnavi; Finn, Aloke V; Owens, Gary K; Joner, Michael; Mayr, Manuel; Civelek, Mete. 2024. Arteriosclerosis, thrombosis, and vascular biology. 44: 898-914 -
Single nucleus RNA-sequencing integrated into risk variant colocalization discovers 17 cell-type-specific abdominal obesity genes for metabolic dysfunction-associated steatotic liver disease
Lee, Seung Hyuk T; Garske, Kristina M; Arasu, Uma Thanigai; Kar, Asha; Miao, Zong; Alvarez, Marcus; Koka, Amogha; Darci-Maher, Nicholas; Benhammou, Jihane N; Pan, David Z; Örd, Tiit; Kaminska, Dorota; Männistö, Ville; Heinonen, Sini; Wabitsch, Martin; Laakso, Markku; Agopian, Vatche G; Pisegna, Joseph R; Pietiläinen, Kirsi H; Pihlajamäki, Jussi; Kaikkonen, Minna U; Pajukanta, Päivi. 2024. EBioMedicine. 106: . 105232