Moustafa Hamada
Doctoral Researcher
Doctoral Researcher
Department of Technical Physics, Faculty of Science, Forestry and Technology
My current research focuses on understanding the mechanobiological processes underlying articular cartilage degeneration following joint injury. To achieve this, I combine experimental characterization of changes in cartilage composition with computational finite element modelling to investigate the biological mechanisms driving cartilage degeneration.
Research groups
Publications
3/3 items-
MMP release following cartilage injury leads to collagen loss in intact tissue: A computational study
Hamada, Moustafa; Eskelinen, Atte SA; Kosonen, Joonas P.; Florea, Cristina; Grodzinsky, Alan J; Tanska, Petri; Korhonen, Rami K, 2026, PLoS computational biology, 22, 1, e1013209. A1 Journal article (refereed), original research -
Time-dependent computational model of post-traumatic osteoarthritis to estimate how mechanoinflammatory mechanisms impact cartilage aggrecan content
Eskelinen, Atte SA; Kosonen, Joonas P; Hamada, Moustafa; Esrafilian, Amir; Florea, Cristina; Grodzinsky, Alan J; Tanska, Petri; Korhonen, Rami K, 2025, PLoS computational biology, 21, 10, e1013641. A1 Journal article (refereed), original research -
Loss of collagen content is localized near cartilage lesions on the day of injurious loading and intensified on day 12
Hamada, Moustafa; Eskelinen, Atte SA; Florea, Cristina; Mikkonen, Santtu; Nieminen, Petteri; Grodzinsky, Alan J; Tanska, Petri; Korhonen, Rami K, 2024, Journal of orthopaedic research, 43, 1, 70-83. A1 Journal article (refereed), original research