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Ossi Korhonen

Ossi Korhonen

Professor

School of Pharmacy, Faculty of Health Sciences

[email protected] | +358 40 355 2458

Information Publications

Research groups

Amorphous formulations 01.08.2005 -
Freeze-drying of biologicals 01.01.2010 -
Continuous Manufacturing of Tablets 01.01.2010 -

Projects

Finland-Southern Africa Research and Educational collaboration in Toxicology and Pharmacy 01.09.2021 - 31.12.2024

Publications

74/74 items

Continuous direct compression of a commercially batch-manufactured tablet formulation with two different processing lines
Lyytikäinen, Jenna; Stasiak, Pawel; Kubelka, Tomáš; Bogaerts, Ivan; Wanek, Adam; Stynen, Bart; Holman, James; Ketolainen, Jarkko; Ervasti, Tuomas; Korhonen, Ossi. 2024. European journal of pharmaceutics and biopharmaceutics. 199: A1 Journal article (refereed), original research
Extending the shelf life of HLM chips through freeze-drying of human liver microsomes immobilized onto thiol-ene micropillar arrays
Rautsola, Iiro; Haapala, Markus; Huttunen, Leo; Korhonen, Ossi; Sikanen, Tiina. 2024. Lab on a chip. 24: 4211-4220 A1 Journal article (refereed), original research
Freeze-drying-induced mutarotation of lactose detected by Raman spectroscopy
Monola, Julia; Koivunotko, Elle; Zini, Jacopo; Niemelä, Akseli; Koivuniemi, Artturi; Kröger, Aleksi; Korhonen, Ossi; Valkonen, Sami; Merivaara, Arto; Harjumäki, Riina; Yliperttula, Marjo; Kekkonen, Jere. 2024. European journal of pharmaceutics and biopharmaceutics. 205: A1 Journal article (refereed), original research
The effect of process parameters on a continuous blending process monitored in-line by near-infrared spectroscopy
Dias, Rute C; Korhonen, Ossi; Ketolainen, Jarkko; Ervasti, Tuomas; Lopes, João A. 2024. European journal of pharmaceutical sciences. 202: A1 Journal article (refereed), original research
Challenges encountered in the transfer of atorvastatin tablet manufacturing - commercial batch-based production as a basis for small-scale continuous tablet manufacturing tests
Lyytikäinen, Jenna; Kyllönen, Saini; Ervasti, Tuomas; Komulainen, Eelis; Pekarek, Tomáš; Slunečková, Jitka; Leskinen, Jari; Ketolainen, Jarkko; Kubelka, Tomáš; Stasiak, Pawel; Korhonen, Ossi. 2023. International journal of pharmaceutics. 647: . 123509 A1 Journal article (refereed), original research
Flowsheet modelling of a powder continuous feeder-mixer system
Dias, Rute C; Korhonen, Ossi; Ketolainen, Jarkko; Lopes, João A; Ervasti, Tuomas. 2023. International journal of pharmaceutics. 639: A1 Journal article (refereed), original research
Physicochemical stability of high-concentration cefuroxime aqueous injection reconstituted by a centralised intravenous additive service
Vilanti, Anna; Helin-Tanninen, Minna; Isotalo, Antti; Mustonen, Juho; Koskivuori, Johanna; Korhonen, Ossi; Lehtonen, Marko. 2023. European journal of hospital pharmacy: science and practice. [Published Online First: 27 August 2023]: A1 Journal article (refereed), original research
Detecting different amorphous – amorphous phase separation patterns in co-amorphous mixtures with high resolution imaging FTIR spectroscopy
Kilpeläinen, Tuomas; Ervasti, Tuomas; Uurasjärvi, Emilia; Koistinen, Arto; Ketolainen, Jarkko; Korhonen, Ossi; Pajula, Katja. 2022. European journal of pharmaceutics and biopharmaceutics. 180: 161-169 A1 Journal article (refereed), original research
Near-infrared analysis of nanofibrillated cellulose aerogel manufacturing
Merivaara, Arto; Kekkonen, Jere; Monola, Julia; Koivunotko, Elle; Savolainen, Marko; Silvast, Tuomo; Svedström, Kirsi; Diaz, Ana; Holler, Mirko; Korhonen, Ossi; Yliperttula, Marjo; Valkonen, Sami. 2022. International journal of pharmaceutics. 617: A1 Journal article (refereed), original research
Parameter optimization in a continuous direct compression process of commercially batch-produced bisoprolol tablets
Lyytikäinen, Jenna; Stasiak, Pawel; Kubelka, Tomáš; Olenius, Tino; Korhonen, Ossi; Ketolainen, Jarkko; Ervasti, Tuomas. 2022. International journal of pharmaceutics. 628: A1 Journal article (refereed), original research
Biopharmaceutics of Topical Ophthalmic Suspensions: Importance of Viscosity and Particle Size in Ocular Absorption of Indomethacin
Toropainen, Elisa; Fraser-Miller, Sara J; Novakovic, Dunja; Del Amo, Eva M; Vellonen, Kati-Sisko; Ruponen, Marika; Viitala, Tapani; Korhonen, Ossi; Auriola, Seppo; Hellinen, Laura; Reinisalo, Mika; Tengvall, Unni; Choi, Stephanie; Absar, Mohammad; Strachan, Clare; Urtti, Arto. 2021. Pharmaceutics. 13: 452 A1 Journal article (refereed), original research
Determination of Residence Time Distribution in a Continuous Powder Mixing Process With Supervised and Unsupervised Modeling of In-line Near Infrared (NIR) Spectroscopic Data
Pedersena, Troels; Karttunen, Anssi-Pekka; Korhonen, Ossi; Wu, Jian Xiong; Naelapää, Kaisa; Skibsted, Erik; Rantanen, Jukka. 2021. Journal of pharmaceutical sciences. 110: 1259-1269 A1 Journal article (refereed), original research
Molecular Insights on Successful Reconstitution of Freeze-Dried Nanofibrillated Cellulose Hydrogel
Koivunotko, Elle; Merivaara, Arto; Niemelä, Akseli; Valkonen, Sami; Manninen, Kalle; Mäkinen, Henrik; Viljanen, Mira; Svedström, Kirsi; Diaz, Ana; Holler, Mirko; Zini, Jacopo; Paasonen, Lauri; Korhonen, Ossi; Huotari, Simo; Koivuniemi, Artturi; Yliperttula, Marjo. 2021. ACS applied bio materials. 4: 7157-7167 A1 Journal article (refereed), original research
Preparation and characterization of hot-melt extruded polycaprolactone-based filaments intended for 3D-printing of tablets
Viidik, Laura; Vesala, Jemina; Laitinen, Riikka; Korhonen, Ossi; Ketolainen, Jarkko; Aruväli, Jaan; Kirsimäe, Kalle; Kogermann, Karin; Heinämäki, Jyrki; Laidmäe, Ivo; Ervasti, Tuomas. 2021. European journal of pharmaceutical sciences. 158: 105619 A1 Journal article (refereed), original research
Preservation of biomaterials and cells by freeze-drying: Change of paradigm
Merivaara, Arto; Zini, Jacopo; Koivunotko, Elle; Valkonen, Sami; Korhonen, Ossi; Fernandes, Francisco M.; Yliperttula, Marjo. 2021. Journal of controlled release. 336: 480-498 A2 Review article, Literature review, Systematic review
Production and Stability of Amorphous Solid Dispersions Produced by a Freeze-drying Method from DMSO
Valkama, Eetu; Haluska, Ondrej; Lehto, Vesa-Pekka; Korhonen, Ossi; Pajula, Katja. 2021. International journal of pharmaceutics. 606: 120902 A1 Journal article (refereed), original research
Continuous Pharmaceutical Manufacturing
Korhonen, Ossi. 2020. Pharmaceutics. 12: 910 A1 Journal article (refereed), original research
Converting a batch based high-shear granulation process to a continuous dry granulation process; a demonstration with ketoprofen tablets
Taipale-Kovalainen, Krista; Ketolainen, Jarkko; Korhonen, Ossi; Ervasti, Tuomas. 2020. European journal of pharmaceutical sciences. 151: 105381 A1 Journal article (refereed), original research
Detection of amorphous-amorphous phase separation in small molecular co-amorphous mixtures with SEM-EDS
Pajula, Katja; Hyyryläinen, Juha; Koistinen, Arto; Leskinen, Jari T T; Korhonen, Ossi. 2020. European journal of pharmaceutics and biopharmaceutics. 150: 43-49 A1 Journal article (refereed), original research
Raman imaging of amorphous-amorphous phase separation in small molecule co-amorphous systems
Kilpeläinen, Tuomas; Pajula, Katja; Ervasti, Tuomas; Uurasjärvi, Emilia; Koistinen, Arto; Korhonen, Ossi. 2020. European journal of pharmaceutics and biopharmaceutics. 155: 49-54 A1 Journal article (refereed), original research
The Comparison of Two Challenging Low Dose APIs in a Continuous Direct Compression Process
Ervasti, Tuomas; Niinikoski, Hannes;, Mäki-Lohiluoma, Eero; Leppinen, Heidi; Ketolainen, Jarkko; Korhonen, Ossi; Lakio, Satu. 2020. Pharmaceutics. 12: 279 A1 Journal article (refereed), original research
Comparison between integrated continuous direct compression line and batch processing - The effect of raw material properties
Karttunen, AP; Wikström, H; Tajarobi, P; Fransson, M; Sparén, A; Marucci, M; Ketolainen, J; Folestad, S; Korhonen, O; Abrahmsén-Alami, S. 2019. European journal of pharmaceutical sciences. 133: 40-53 A1 Journal article (refereed), original research
Comparison of Traditional and Ultrasound-Enhanced Electrospinning in Fabricating Nanofibrous Drug Delivery Systems
Hakkarainen, E; Kõrkjas, A; Laidmäe, I; Lust, A; Semjonov, K; Kogermann, K; Nieminen, HJ; Salmi, A; Korhonen, O; Haeggström, E; Heinämäki, J. 2019. Pharmaceutics. 11: 495 A1 Journal article (refereed), original research
Measurement of residence time distributions and material tracking on three continuous manufacturing lines
Karttunen, AP; Hörmann, TR; De Leersnyder, F; Ketolainen, J; De Beer, T; Hsiao, WK; Korhonen, O. 2019. International journal of pharmaceutics. 563: 184-197 A1 Journal article (refereed), original research
Robustness of a continuous direct compression line against disturbances in feeding
Karttunen, A-P; Poms, J; Sacher, S; Sparén, A; Ruiz Samblás, C; Fransson, M; Martin De Juan, L; Remmelgas, J; Wikström, H; Hsiao, W K; Folestad, S; Korhonen, O; Abrahmsén-Alami, S; Tajarobi, P. 2019. International journal of pharmaceutics. 2020; 574: 118882 A1 Journal article (refereed), original research
Control of three different continuous pharmaceutical manufacturing processes: Use of soft sensors
Rehrl, Jakkob; Karttunen, Anssi-Pekka; Nicolaï, Niels; Hörmann, Theresa; Horn, Martin; Korhonen, Ossi; Nopens, Ingmar; De Beer, Thomas; Khinast, Johannes G. 2018. International journal of pharmaceutics. 543: 60-72 A1 Journal article (refereed), original research
Investigating elastic relaxation effects on the optical properties of functionalised calcium carbonate compacts using optics-based Heckel analysis
Bawuah, Prince; Karttunen, Anssi-Pekka; Markl, Daniel; Ridgway, Cathy; Korhonen, Ossi; Gane, Patrick; Zeitler, J Axel; Ketolainen, Jarkko; Peiponen, Kai-Erik. 2018. International journal of pharmaceutics. 544: 278-284 A1 Journal article (refereed), original research
Preparation and characterization of multi-component tablets containing co-amorphous salts: combining multimodal non-linear optical imaging with established analytical methods
Ojarinta, Rami; Saarinen, Jukka; Strachan, Clare J; Korhonen, Ossi; Laitinen, Riikka. 2018. European journal of pharmaceutics and biopharmaceutics. 132: 112-126 A1 Journal article (refereed), original research
RTD-based Material Tracking in a Fully-Continuous Dry Granulation Tableting Line
Martinetz, MC; Karttunen, AP; Sacher, S; Wahl, P; Ketolainen, J; Khinast, JG; Korhonen, O. 2018. International journal of pharmaceutics. 547: 469-479 A1 Journal article (refereed), original research
The effect of light sensitizer localization on the stability of indocyanine green liposomes
Lajunen, T; Nurmi, R; Wilbie, D; Ruoslahti, T; Johansson, NG; Korhonen, O; Rog, T; Bunker, A; Ruponen, M; Urtti, A. 2018. Journal of controlled release. 284: 213-223 A1 Journal article (refereed), original research
The effects of unintentional and intentional process disturbances on tablet quality during long continuous manufacturing runs
Taipale-Kovalainen, Krista; Karttunen, Anssi-Pekka; Niinikoski, Hannes; Ketolainen, Jarkko; Korhonen, Ossi. 2018. European journal of pharmaceutical sciences. 2019; 129: 10-20 A1 Journal article (refereed), original research
A Review of PAT Strategies in Secondary Solid Oral Dosage Manufacturing of Small Molecules
Laske S, Paudel A, Scheibelhofer O, Sacher S, Hoermann T, Khinast J, Kelly A, Rantannen J, Korhonen O, Stauffer F, De Leersnyder F, De Beer T, Mantanus J, Chavez PF, Thoorens B, Ghiotti P, Schubert M, Tajarobi P, Haeffler G, Lakio S et al.. 2017. Journal of pharmaceutical sciences. 106: 667-712 A2 Review article, Literature review, Systematic review
Effect of storage on the physical stability of thin polymethacrylate-perphenazine films
Korhonen Kristiina, Smolander Elina, Korhonen Ossi, Ketolainen Jarkko, Laitinen Riikka. 2017. European journal of pharmaceutical sciences. 104: 293-301 A1 Journal article (refereed), original research
Lubricant based determination of design space for continuously manufactured high dose paracetamol tablets
Taipale-Kovalainen Krista, Karttunen Anssi-Pekka, Ketolainen Jarkko, Korhonen Ossi. 2017. European journal of pharmaceutical sciences. 2018; 115: 1-10 A1 Journal article (refereed), original research
Provoking an end-to-end continuous direct compression line with raw materials prone to segregation
Lakio S, Ervasti T, Tajarobi P, Wikström H, Fransson M, Karttunen AP, Ketolainen J, Folestad S, Abrahmsén-Alami S, Korhonen O. 2017. European journal of pharmaceutical sciences. 109: 514-524 A1 Journal article (refereed), original research
Surface area, volume and shape descriptors as a novel tool for polymer lead design and discovery
Christensen JR, Meng-Lund H, Grohganz H, Poso A, Laitinen T, Korhonen O, Jørgensen L, Pajander J. 2017. European journal of pharmaceutical sciences. 102: 188-195 A1 Journal article (refereed), original research
Continuous manufacturing of tablets with PROMIS-line - Introduction and case studies from continuous feeding, blending and tableting
Simonaho Simo-Pekka, Ketolainen Jarkko, Ervasti Tuomas, Toiviainen Maunu, Korhonen Ossi. 2016. European journal of pharmaceutical sciences. 90: 38-46 A1 Journal article (refereed), original research
Rational excipient selection for co-amorphous formulations
Korhonen Ossi, Pajula Katja, Laitinen Riikka. 2016. Expert opinion on drug delivery. 2017; 14: 551-569 A2 Review article, Literature review, Systematic review
Systematic evaluation of a spraying method for preparing thin Eudragit-drug films by Design of Experiments
Korhonen Kristiina, Poikolainen Mirja, Korhonen Ossi, Ketolainen Jarkko, Laitinen Riikka. 2016. Journal of drug delivery science and technology. 35: 241-251 A1 Journal article (refereed), original research
Pharmaceutical solids and processes
Ketolainen Jarkko, Korhonen Ossi, Laitinen Riikka, Simonaho Simo-Pekka, Molnár Ferdinand. 2014. Dosis. 30: 195 B1 Non-refereed journal articles
Phase separation in co-amorphous systems: in silico prediction and the experimental challenge of detection
Pajula Katja, Wittoek Lieke, Lehto Vesa-Pekka, Ketolainen Jarkko, Korhonen Ossi. 2014. Molecular pharmaceutics. 11: 2271-2279 A1 Journal article (refereed), original research
Effect of storage on the dissolution rate of a fast-dissolving perphenazine/&#946 -cyclodextrin complex
Turunen Elina, Korhonen Ossi, Lehto Vesa-Pekka, Kauppinen Ari, Ahtiainen Hanne, Järvinen Kristiina, Jarho Pekka. 2013. Journal of pharmacy and pharmacology. 2014:66: 367-377 A1 Journal article (refereed), original research
In-line multipoint near-infrared spectroscopy for moisture content quantification during freeze-drying
Kauppinen Ari, Toiviainen Maunu, Korhonen Ossi, Aaltonen Jaakko, Järvinen Kristiina, Paaso Janne, Juuti Mikko, Ketolainen Jarkko. 2013. Analytical chemistry. 85: 2377-2384 A1 Journal article (refereed), original research
Micro-scale freeze-drying with Raman spectroscopy as a tool for process development
Kauppinen Ari, Toiviainen Maunu, Aaltonen Jaakko, Korhonen Ossi, Järvinen Kristiina, Juuti Mikko, Pellinen Riikka, Ketolainen Jarkko. 2013. Polymorfi
Microscale freeze-drying with Raman spectroscopy as a tool for process development
Kauppinen Ari, Toiviainen Maunu, Aaltonen Jaakko, Korhonen Ossi, Järvinen Kristiina, Juuti Mikko, Pellinen Riikka, Ketolainen Jarkko. 2013. Analytical chemistry. 85: 2109-2116 A1 Journal article (refereed), original research
Co-amorphous simvastatin and glipizide combinations show improved physical stability without evidence of intermolecular interactions
Löbmann Korbinian, Strachan Clare, Grohganz Holger, Rades Thomas, Korhonen Ossi, Laitinen Riikka. 2012. European journal of pharmaceutics and biopharmaceutics. 81: 159-169 A1 Journal article (refereed), original research
Computational approach for fast screening of small molecular candidates to inhibit crystallization in amorphous drugs
Pajula Katja, Lehto Vesa-Pekka, Ketolainen Jarkko, Korhonen Ossi. 2012. Molecular pharmaceutics. 9: 2844-2855 A1 Journal article (refereed), original research
Freeze drying formulation and process design using Raman spectrometer equipped micro scale freeze drying stage
Kauppinen Ari, Toiviainen Maunu, Korhonen Ossi, Aaltonen Jaakko, Järvinen Kristiina, Juuti Mikko, Ketolainen Jarkko. 2012.
In-line moisture content monitoring of the freeze dried products using multipoint NIR spectroscopy
Kauppinen Ari, Toiviainen Maunu, Korhonen Ossi, Aaltonen Jaakko, Järvinen Kristiina, Juuti Mikko, Ketolainen Jarkko. 2012.
Surface Chemistry, Reactivity, and Pore Structure of Porous Silicon Oxidized by Various Methods
Riikonen Joakim, Salomäki Mikko, van Wonderen Jessica , Kemell Marianna, Xu, Wujun, Korhonen Ossi, Ritala Mikko, MacMillan Fraser, Salonen Jarno, Lehto Vesa-Pekka. 2012. Langmuir. 28: 10573−10583 A1 Journal article (refereed), original research
Determination of water content in freeze dried samples using NIR spectroscopy
Kauppinen Ari, Toiviainen Maunu, Aaltonen Jaakko, Korhonen Ossi, Järvinen Kristiina, Ketolainen Jarkko. 2011. Polymorfi
Design of freeze drying process for an adenovirus vector
Kauppinen Ari, Pellinen Riika, Karjalainen Mikko, Korhonen Ossi, Aaltonen Jaakko, Heikkilä Katri, Järvinen Kristiina, Nokelainen Minna, Ketolainen Jarkko. 2010.
Effect of freeze-drying conditions on transfection efficiency of cationic polymer DNA complexes
Kauppinen Ari, Reinisalo Mika, Pellinen Riikka, Korhonen Ossi, Järvinen Kristiina, Ketolainen Jarkko. 2010. Polymorfi
Predicting the formation and stability of amorphous small molecule binary mixtures from computationally determined Flory-Huggins interaction parameter and phase diagram
Pajula K, Taskinen M, Lehto V-P, Ketolainen J & Korhonen O. 2010. Molecular pharmaceutics. 7: 795-804 A1 Journal article (refereed), original research
Determining the critical properties of formulations for freeze drying by DSC and FDM
Kauppinen Ari, Reinisalo Mika, Pellinen Riikka, Gieseler Henning, Schneid Stefan, Rutzinger Susanne, Beirowski Jakob, Korhonen Ossi, Järvinen Kristiina, Ketolainen Jarkko. 2009.
Effect of formulation parameters and drug-polymer interactions on drug release from starch acetate matrix tablets
Pajander J, Korhonen O, Laamanen M, Ryynänen E-L, Grimsey I, Van Veen B, Ketolainen J. 2009. Journal of pharmaceutical sciences. 98: 3676-3690 A1 Journal article (refereed), original research
Correlation between molecular mobility and crystal growth of amorphous phenobarbital and phenobarbital with polyvinylpyrrolidone and L-proline
Korhonen O, Bhugra C, Pikal MJ. 2008. Journal of pharmaceutical sciences. 97: 3830-3841 A1 Journal article (refereed), original research
Drug release phenomena within a hydrophobic starch acetate matrix: FTIR mapping of tablets after in vitro dissolution testing
Pajander J, Soikkeli A, Korhonen O, Forbes RT, Ketolainen J. 2008. Journal of pharmaceutical sciences. 97: 3367-3378 A1 Journal article (refereed), original research
Estimation of drug release profiles of a heterogeneous set of drugs from a hydrophobic matrix tablet using molecular descriptors
Matero S, Reinikainen S-P, Lahtela-Kakkonen M, Korhonen O, Ketolainen J, Poso A. 2008. Journal of chemometrics. 22: 653-660 A1 Journal article (refereed), original research
Predicting the drug concentration in starch acetate matrix tablets from ATR-FTIR spectra using multi-way methods
Matero S, Pajander J, Soikkeli A-M, Reinikainen S-P, Lahtela-Kakkonen M, Korhonen O, Ketolainen J, Poso A. 2007. Analytica chimica acta. 595: 190-197 A1 Journal article (refereed), original research
Chemical space of orally active compounds
Matero S, Lahtela-Kakkonen M, Korhonen O, Ketolainen J, Lappalainen R, Poso A. 2006. Chemometrics and intelligent laboratory systems. 84: 134-141 A1 Journal article (refereed), original research
Controlled release of saccharides from matrix tablets
Mäki R, Suihko E, Korhonen O, Pitkänen H, Niemi R, Lehtonen M, Ketolainen J. 2006. European journal of pharmaceutics and biopharmaceutics. 62: 163-170 A1 Journal article (refereed), original research
Liquid boundary movements in cylindrical and convex hydrophobic matrix tablets: effects on tablet cracking and drug release
Pajander J, van Veen B, Korhonen O, Lappalainen R, Ketolainen J. 2006. European journal of pharmaceutics and biopharmaceutics. 64: 167-172 A1 Journal article (refereed), original research
Partial least square projections to latent structures analysis (PLS) in evaluating and predicting drug release from starch acetate matrix tablets
Korhonen O, Matero S, Poso A, Ketolainen J. 2005. Journal of pharmaceutical sciences. 94: 2716-2730 A1 Journal article (refereed), original research
Prediction of contact angle for pharmaceutical solids from their molecular structure
Suihko E, Forbes RT, Korhonen O, Ketolainen J, Paronen P, Gynther J, Poso A. 2005. Journal of pharmaceutical sciences. 94: 745-758 A1 Journal article (refereed), original research
Evaluation of novel starch acetate-diltiazem controlled release tablets in healthy human volunteers
Korhonen O, Kanerva H, Vidgren M, Urtti A, Ketolainen J. 2004. Journal of controlled release. 95: 515-520 A1 Journal article (refereed), original research
Starch Acetate as a Novel Tablet Excipient for Extended Oral Drug Delivery
Korhonen O. 2004. Kuopion yliopiston julkaisuja A. Farmaseuttiset tieteet G5 Doctoral dissertation (article)
Acetylation enhances the tabletting properties of starch
Raatikainen P, Korhonen O, Peltonen S, Paronen P. 2002. Drug development and industrial pharmacy. 28: 165-175 A1 Journal article (refereed), original research
Effects of physical properties for starch acetate powders on tableting [online]
Korhonen O, Pohja S, Peltonen S, Suihko E, Vidgren M, Paronen P, Ketolainen J. 2002. AAPS PharmSciTech. 3: [21.2.2003] A1 Journal article (refereed), original research
Complexation with tolbutamide modifies the physicochemical and tableting properties of hydroxypropyl-beta-cyclodextrin
Suihko E, Korhonen O, Järvinen T, Ketolainen J, Jarho P, Laine E, Paronen P. 2001. International journal of pharmaceutics. 215: 137-145 A1 Journal article (refereed), original research
Deformation behaviors of tolbutamide, hydroxypropyl-beta-cyclodextrin, and their dispersions
Suihko E, Poso A, Korhonen O, Gynther J, Ketolainen J, Paronen P. 2000. Pharmaceutical research. 17: 942-948 A1 Journal article (refereed), original research
Starch acetates - multifunctional direct compression excipients
Korhonen O, Raatikainen P, Harjunen P, Nakari J, Suihko E, Peltonen S, Vidgren M, Paronen P. 2000. Pharmaceutical research. 17: 1138-1143 A1 Journal article (refereed), original research
Evaluation of physical properties of tolbutamide/hydroxypropyl-ß-cyclodextrin inclusion complex
Suihko E, Korhonen O, Järvinen T, Ketolainen J, Laine E, Paronen P. Teoksessa: (toim.) , 1997. 16th Pharmaceutical Technology Conference and Exhibition. Vol. 2.. s. 286-294. A4 Conference proceedings
Menetelmiä hiukkasten muokkaamisesta suorapuristukseen
Korhonen O. 1997. Polymorfi. : 7-9 D1 Article in a trade journal

University of Eastern Finland Joensuu, Kuopio © University of Eastern Finland

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Ossi Korhonen

Research groups

Projects

Continuous direct compression of a commercially batch-manufactured tablet formulation with two different processing lines

Extending the shelf life of HLM chips through freeze-drying of human liver microsomes immobilized onto thiol-ene micropillar arrays

Freeze-drying-induced mutarotation of lactose detected by Raman spectroscopy

The effect of process parameters on a continuous blending process monitored in-line by near-infrared spectroscopy

Challenges encountered in the transfer of atorvastatin tablet manufacturing - commercial batch-based production as a basis for small-scale continuous tablet manufacturing tests

Flowsheet modelling of a powder continuous feeder-mixer system

Physicochemical stability of high-concentration cefuroxime aqueous injection reconstituted by a centralised intravenous additive service

Detecting different amorphous – amorphous phase separation patterns in co-amorphous mixtures with high resolution imaging FTIR spectroscopy

Near-infrared analysis of nanofibrillated cellulose aerogel manufacturing

Parameter optimization in a continuous direct compression process of commercially batch-produced bisoprolol tablets

Biopharmaceutics of Topical Ophthalmic Suspensions: Importance of Viscosity and Particle Size in Ocular Absorption of Indomethacin

Determination of Residence Time Distribution in a Continuous Powder Mixing Process With Supervised and Unsupervised Modeling of In-line Near Infrared (NIR) Spectroscopic Data

Molecular Insights on Successful Reconstitution of Freeze-Dried Nanofibrillated Cellulose Hydrogel

Preparation and characterization of hot-melt extruded polycaprolactone-based filaments intended for 3D-printing of tablets

Preservation of biomaterials and cells by freeze-drying: Change of paradigm

Production and Stability of Amorphous Solid Dispersions Produced by a Freeze-drying Method from DMSO

Continuous Pharmaceutical Manufacturing

Converting a batch based high-shear granulation process to a continuous dry granulation process; a demonstration with ketoprofen tablets

Detection of amorphous-amorphous phase separation in small molecular co-amorphous mixtures with SEM-EDS

Raman imaging of amorphous-amorphous phase separation in small molecule co-amorphous systems

The Comparison of Two Challenging Low Dose APIs in a Continuous Direct Compression Process

Comparison between integrated continuous direct compression line and batch processing - The effect of raw material properties

Comparison of Traditional and Ultrasound-Enhanced Electrospinning in Fabricating Nanofibrous Drug Delivery Systems

Measurement of residence time distributions and material tracking on three continuous manufacturing lines

Robustness of a continuous direct compression line against disturbances in feeding

Control of three different continuous pharmaceutical manufacturing processes: Use of soft sensors

Investigating elastic relaxation effects on the optical properties of functionalised calcium carbonate compacts using optics-based Heckel analysis

Preparation and characterization of multi-component tablets containing co-amorphous salts: combining multimodal non-linear optical imaging with established analytical methods

RTD-based Material Tracking in a Fully-Continuous Dry Granulation Tableting Line

The effect of light sensitizer localization on the stability of indocyanine green liposomes

The effects of unintentional and intentional process disturbances on tablet quality during long continuous manufacturing runs

A Review of PAT Strategies in Secondary Solid Oral Dosage Manufacturing of Small Molecules

Effect of storage on the physical stability of thin polymethacrylate-perphenazine films

Lubricant based determination of design space for continuously manufactured high dose paracetamol tablets

Provoking an end-to-end continuous direct compression line with raw materials prone to segregation

Surface area, volume and shape descriptors as a novel tool for polymer lead design and discovery

Continuous manufacturing of tablets with PROMIS-line - Introduction and case studies from continuous feeding, blending and tableting

Rational excipient selection for co-amorphous formulations

Systematic evaluation of a spraying method for preparing thin Eudragit-drug films by Design of Experiments

Pharmaceutical solids and processes

Phase separation in co-amorphous systems: in silico prediction and the experimental challenge of detection

Effect of storage on the dissolution rate of a fast-dissolving perphenazine/&#946 -cyclodextrin complex

In-line multipoint near-infrared spectroscopy for moisture content quantification during freeze-drying

Micro-scale freeze-drying with Raman spectroscopy as a tool for process development

Microscale freeze-drying with Raman spectroscopy as a tool for process development

Co-amorphous simvastatin and glipizide combinations show improved physical stability without evidence of intermolecular interactions

Computational approach for fast screening of small molecular candidates to inhibit crystallization in amorphous drugs

Freeze drying formulation and process design using Raman spectrometer equipped micro scale freeze drying stage

In-line moisture content monitoring of the freeze dried products using multipoint NIR spectroscopy

Surface Chemistry, Reactivity, and Pore Structure of Porous Silicon Oxidized by Various Methods

Determination of water content in freeze dried samples using NIR spectroscopy

Design of freeze drying process for an adenovirus vector

Effect of freeze-drying conditions on transfection efficiency of cationic polymer DNA complexes

Predicting the formation and stability of amorphous small molecule binary mixtures from computationally determined Flory-Huggins interaction parameter and phase diagram

Determining the critical properties of formulations for freeze drying by DSC and FDM

Effect of formulation parameters and drug-polymer interactions on drug release from starch acetate matrix tablets

Correlation between molecular mobility and crystal growth of amorphous phenobarbital and phenobarbital with polyvinylpyrrolidone and L-proline

Drug release phenomena within a hydrophobic starch acetate matrix: FTIR mapping of tablets after in vitro dissolution testing

Estimation of drug release profiles of a heterogeneous set of drugs from a hydrophobic matrix tablet using molecular descriptors

Predicting the drug concentration in starch acetate matrix tablets from ATR-FTIR spectra using multi-way methods

Chemical space of orally active compounds

Controlled release of saccharides from matrix tablets

Liquid boundary movements in cylindrical and convex hydrophobic matrix tablets: effects on tablet cracking and drug release

Partial least square projections to latent structures analysis (PLS) in evaluating and predicting drug release from starch acetate matrix tablets

Prediction of contact angle for pharmaceutical solids from their molecular structure

Evaluation of novel starch acetate-diltiazem controlled release tablets in healthy human volunteers

Starch Acetate as a Novel Tablet Excipient for Extended Oral Drug Delivery

Acetylation enhances the tabletting properties of starch

Effects of physical properties for starch acetate powders on tableting [online]

Complexation with tolbutamide modifies the physicochemical and tableting properties of hydroxypropyl-beta-cyclodextrin

Deformation behaviors of tolbutamide, hydroxypropyl-beta-cyclodextrin, and their dispersions

Starch acetates - multifunctional direct compression excipients

Evaluation of physical properties of tolbutamide/hydroxypropyl-ß-cyclodextrin inclusion complex

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