Piia Bartos
Senior Researcher
Computer-aided drug design with simulations of small noncoding-RNA molecules and understanding their function in cancer and cardiovascular diseases.
School of Pharmacy, Faculty of Health Sciences
piia.bartos@uef.fi
I am a pharmaceutical chemist with my research interests now in short non-coding RNA sequences and how to mimic their function using synthetic drugs. My background is in Pharmacy, and I defended my Doctoral thesis in drug design of sirtuins in autumn 2015 in UEF. After my dissertation, I left to study molecular dynamics methods and enzyme engineering to Brno, Czech Republic. I can use all the basic tools of computational drug design, including docking and molecular dynamics simulations and up to some simple quantum chemistry calculations.
Research groups
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Publications
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Direct pathway cloning and expression of the radiosumin biosynthetic gene cluster
Ouyang, Xiaodan; D'Agostino, Paul M; Wahlsten, Matti; Delbaje, Endrews; Jokela, Jouni; Permi, Perttu; Gaiani, Greta; Poso, Antti; Bartos, Piia; Gulder, Tobias AM; Koistinen, Hannu; Fewer, David P. 2023. Organic and biomolecular chemistry. 21: 4893-4908 -
RNA-protein complexes and force field polarizability
Baltrukevich, Hanna; Bartos, Piia. 2023. Frontiers in chemistry. 11: . 1217506 -
Structure of POPC Lipid Bilayers in OPLS3e Force Field
Kurki, Milla; Poso, Antti; Bartos, Piia; Miettinen, Markus S. 2022. Journal of chemical information and modeling. 62: 6462–6474 -
Studying sirtuin inhibitors with in silico and in vitro approaches
Kokkonen Piia. 2015. Publications of the University of Eastern Finland. Dissertations in Health Sciences -
Virtual screening approach of sirtuin inhibitors results in two new scaffolds
Kokkonen Piia, Kokkola Tarja, Suuronen Tiina, Poso Antti, Jarho Elina, Lahtela-Kakkonen Maija. 2015. European journal of pharmaceutical sciences. 76: 27-32 -
Quantitative insights for the design of substrate-based SIRT1 inhibitors
Kokkonen Piia, Mellini Paolo, Nyrhilä Olli, Rahnasto-Rilla Minna, Suuronen Tiina, Kiviranta Päivi, Huhtiniemi Tero, Poso Antti, Jarho Elina, Lahtela-Kakkonen Maija. 2014. European journal of pharmaceutical sciences. 59: 12-19 -
Studying SIRT6 regulation using H3K56 based substrate and small molecules
Kokkonen Piia, Rahnasto-Rilla Minna, Mellini Paolo, Jarho Elina, Lahtela-Kakkonen Maija, Kokkola Tarja. 2014. European journal of pharmaceutical sciences. 63: 71-76 -
Peptides and Pseudopeptides as SIRT6 Inhibitors
Piia Kokkonen, Minna Rahnasto-Rilla, Päivi Kiviranta, Tero Huhtiniemi, Tuomo Laitinen, Antti Poso, Elina Jarho, Maija Lahtela-Kakkonen. 2012. -
Peptides and pseudopeptides as SIRT6 deacetylation inhibitors
Kokkonen Piia, Rahnasto-Rilla Minna, Kiviranta Päivi H, Huhtiniemi Tero, Laitinen Tuomo, Poso Antti, Jarho Elina, Lahtela-Kakkonen Maija. 2012. Acs medicinal chemistry letters. 3: 969-974