Prosanta Singha - UEFConnect

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Single-cell RNA sequencing reveals sex differences in the subcellular composition and associated gene-regulatory network activity of human carotid plaques
Sukhavasi, Katyayani; Mocci, Giuseppe; Ma, Lijiang; Hodonsky, Chani J.; Diez Benevante, Ernest; Muhl, Lars; Liu, Jianping; Gustafsson, Sonja; Buyandelger, Byambajav; Koplev, Simon; Lendahl, Urban; Vanlandewijck, Michael; Singha, Prosanta; Örd, Tiit; Beter, Mustafa; Selvarajan, Ilakya; Laakkonen, Johanna P.; Väli, Marika; den Ruijter, Hester M.; Civelek, Mete; Hao, Ke; Ruusalepp, Arno; Betsholtz, Christer; Järve, Heli; Kovacic, Jason C.; Miller, Clint L.; Romanoski, Casey; Kaikkonen, Minna U.; Bj, 2025, Nature cardiovascular research, 4, 4, 412–432. A1 Journal article (refereed), original research
Single-Cell Gene-Regulatory Networks of Advanced Symptomatic Atherosclerosis
Mocci, Giuseppe; Sukhavasi, Katyayani; Örd, Tiit; Bankier, Sean; Singha, Prosanta; Arasu, Uma Thanigai; Agbabiaje, Olayinka Oluwasegun; Mäkinen, Petri; Ma, Lijiang; Hodonsky, Chani J; Aherrahrou, Redouane; Muhl, Lars; Liu, Jianping; Gustafsson, Sonja; Byandelger, Byambajav; Wang, Ying; Koplev, Simon; Lendahl, Urban; Owens, Gary; Leeper, Nicholas J; Pasterkamp, Gerard; Vanlandewijck, Michael; Michoel, Tom; Ruusalepp, Arno; Hao, Ke; Ylä-Herttuala, Seppo; Väli, Marika; Järve, Heli; Mokry, Michal; C, 2024, Circulation research, 134, 11, 1405-1423. A1 Journal article (refereed), original research
Transcriptomic and spatial dissection of human ex vivo right atrial tissue reveals proinflammatory microvascular changes in ischemic heart disease
Linna-Kuosmanen, Suvi; Schmauch, Eloi; Galani, Kyriakitsa; Ojanen, Johannes; Boix, Carles A; Örd, Tiit; Toropainen, Anu; Singha, Prosanta K; Moreau, Pierre R; Harju, Kristiina; Blazeski, Adriana; Segerstolpe, Åsa; Lahtinen, Veikko; Hou, Lei; Kang, Kai; Meibalan, Elamaran; Agudelo, Leandro Z; Kokki, Hannu; Halonen, Jari; Jalkanen, Juho; Gunn, Jarmo; MacRae, Calum A; Hollmén, Maija; Hartikainen, Juha EK; Kaikkonen, Minna U; García-Cardeña, Guillermo; Tavi, Pasi; Kiviniemi, Tuomas; Kellis, Manolis, 2024, Cell reports medicine, 5, 5, 101556. A1 Journal article (refereed), original research
Genetic Regulation of SMC Gene Expression and Splicing Predict Causal CAD Genes
Aherrahrou, Rédouane; Lue, Dillon; Perry, R Noah; Aberra, Yonathan Tamrat; Khan, Mohammad Daud; Soh, Joon Yuhl; Örd, Tiit; Singha, Prosanta; Yang, Qianyi; Gilani, Huda; Benavente, Ernest Diez; Wong, Doris; Hinkle, Jameson; Ma, Lijiang; Sheynkman, Gloria M; den Ruijter, Hester M; Miller, Clint L; Björkegren, Johan LM; Kaikkonen, Minna U; Civelek, Mete, 2023, Circulation research, 132, 3, 323-338. A1 Journal article (refereed), original research
The angiopoietin receptor Tie2 is atheroprotective in arterial endothelium
Anisimov, Andrey; Fang, Shentong; Hemanthakumar, Karthik Amudhala; Örd, Tiit; van Avondt, Kristof; Chevre, Raphael; Toropainen, Anu; Singha, Prosanta; Gilani, Huda; Nguyen, Su D; Karaman, Sinem; Korhonen, Emilia A; Adams, Ralf H.; Augustin, Hellmut G; Öörni, Katariina; Soehnlein, Oliver; Kaikkonen, Minna U; Alitalo, Kari, 2023, Nature cardiovascular research, 2, 3, 307-321. A1 Journal article (refereed), original research
Development of methods and inhibitors to target key enzymatic nodes generating protumorigenic lipid signaling
Singha, Prosanta Kumar, 2020, Publications of the University of Eastern Finland. Dissertations in Health Sciences. G5 Doctoral dissertation (article)
Evaluation of FASN inhibitors by a versatile toolkit reveals differences in pharmacology between human and rodent FASN preparations and in antiproliferative efficacy in vitro vs. in situ in human cancer cells
Singha, Prosanta; Mäklin, Kiira; Vihavainen, Taina; Laitinen, Tuomo; Nevalainen, Tapio; Patil, Mahadeo; Tonduru, Arun; Poso, Antti; Laitinen, Jarmo; Savinainen, Juha, 2020, European journal of pharmaceutical sciences, 149, 105321. A1 Journal article (refereed), original research
High-Resolution Confocal Fluorescence Imaging of Serine Hydrolase Activity in Cryosections - Application to Glioma Brain Unveils Activity Hotspots Originating from Tumor-Associated Neutrophils
Aaltonen, Niina; Singha, Prosanta; Jakupovic, Hermina; Wirth, Thomas; Samaranayake, Haritha; Pasonen-Seppänen, Sanna; Rilla, Kirsi; Varjosalo, Markku; Edgington-Mitchell, Laura; Kasperkiewicz, Paulina; Drag, Marcin; Kälvälä, Sara; Moisio, Eemeli; Savinainen, Juha; Laitinen, Jarmo, 2020, Biological procedures online, 22, 6. A1 Journal article (refereed), original research
Design, Synthesis, and Biological Evaluation of 2,4-Dihydropyrano[2,3-c]pyrazole Derivatives as Autotaxin Inhibitors
Pantsar T, Singha P, Nevalainen TJ, Koshevoy I, Leppänen J, Poso A, Niskanen JMA, Pasonen-Seppänen S, Savinainen JR, Laitinen T, Laitinen JT, 2017, European journal of pharmaceutical sciences, 107, 97-111. A1 Journal article (refereed), original research