Riikka Laitinen

From waste to a resource? Hemicelluloses enhance the dissolution and stability of the amorphous state of carbamazepine

Mikkonen, Kirsi S; Latukka, Reetta; Morais de Carvalho, Danila; Laitinen, Riikka. 2024. Sustainable chemistry and pharmacy. 37:

Farmasian teknologia ja biofarmasia

Honkakoski, Paavo; Laitinen, Riikka. 2023. Publications of the University of Eastern Finland. General series. 44: 38-43

PE and PET oligomers’ interplay with membrane bilayers

Järvenpää, Joni; Perkkiö, Milla; Laitinen, Riikka; Lahtela-Kakkonen, Maija. 2022. Scientific reports. 12: . 2234

Production and characterization of glibenclamide incorporated PLA filaments for 3D printing by fused deposition modeling

Kukkonen, Juho; Ervasti, Tuomas; Laitinen, Riikka. 2022. Journal of drug delivery science and technology. 77:

Co-Amorphous Formulations of Furosemide with Arginine and P-Glycoprotein Inhibitor Drugs

Ruponen, Marika; Kettunen, Konsta; Santiago Pires, Monica; Laitinen, Riikka. 2021. Pharmaceutics. 13: 171

Preparation and characterization of hot-melt extruded polycaprolactone-based filaments intended for 3D-printing of tablets

Viidik, Laura; Vesala, Jemina; Laitinen, Riikka; Korhonen, Ossi; Ketolainen, Jarkko; Aruväli, Jaan; Kirsimäe, Kalle; Kogermann, Karin; Heinämäki, Jyrki; Laidmäe, Ivo; Ervasti, Tuomas. 2021. European journal of pharmaceutical sciences. 158: 105619

Dissolution and permeability properties of co-amorphous formulations of hydrochlorothiazide

Ruponen, Marika; Rusanen, Henna; Laitinen, Riikka. 2020. Journal of pharmaceutical sciences. 109: 2252-2261

The effect of co-amorphization of glibenclamide on its dissolution properties and permeability through an MDCKII-MDR1 cell layer

Sormunen, Henri; Ruponen, Marika; Laitinen, Riikka. 2019. International journal of pharmaceutics. 570: 118653

Permeability of glibenclamide through a PAMPA membrane: the effect of co-amorphization

Ruponen, Marika; Visti, Maiju; Ojarinta, Rami; Laitinen, Riikka. 2018. European journal of pharmaceutics and biopharmaceutics. 129: 247-256

Preparation and characterization of multi-component tablets containing co-amorphous salts: combining multimodal non-linear optical imaging with established analytical methods

Ojarinta, Rami; Saarinen, Jukka; Strachan, Clare J; Korhonen, Ossi; Laitinen, Riikka. 2018. European journal of pharmaceutics and biopharmaceutics. 132: 112-126

Effect of storage on the physical stability of thin polymethacrylate-perphenazine films

Korhonen Kristiina, Smolander Elina, Korhonen Ossi, Ketolainen Jarkko, Laitinen Riikka. 2017. European journal of pharmaceutical sciences. 104: 293-301

Reflectometric monitoring of the dissolution process of thin polymeric films

Laitinen R, Räty J, Korhonen K, Ketolainen J, Peiponen K-E. 2017. International journal of pharmaceutics. 523: 127-132

Spray drying of poorly soluble drugs from aqueous arginine solution

Ojarinta R, Lerminiaux L, Laitinen R. 2017. International journal of pharmaceutics. 532: 289-298

Supersaturating drug delivery systems: the potential of co-amorphous drug formulations

Laitinen Riikka, Löbmann Korbinian, Grohganz Holger, Priemel Petra, Strachan Clare J, Rades Thomas. 2017. International journal of pharmaceutics. 532: 1-12

Dissolution behavior of co-amorphous amino acid-indomethacin mixtures: The ability of amino acids to stabilize the supersaturated state of indomethacin

Ojarinta Rami, Heikkinen Aki T, Sievänen Elina, Laitinen Riikka. 2016. European journal of pharmaceutics and biopharmaceutics. 2017; 112: 85-95

Rational excipient selection for co-amorphous formulations

Korhonen Ossi, Pajula Katja, Laitinen Riikka. 2016. Expert opinion on drug delivery. 2017; 14: 551-569

Systematic evaluation of a spraying method for preparing thin Eudragit-drug films by Design of Experiments

Korhonen Kristiina, Poikolainen Mirja, Korhonen Ossi, Ketolainen Jarkko, Laitinen Riikka. 2016. Journal of drug delivery science and technology. 35: 241-251

Characterization of Amorphous and Co-Amorphous Simvastatin Formulations Prepared by Spray Drying

Craye Goedele, Löbmann Korbinian, Grohganz Holger, Rades Thomas, Laitinen Riikka. 2015. Molecules. 20: 21532-21548

Dissolution properties of co-amorphous drug-amino acid formulations in buffer and biorelevant media

Heikkinen Aki T, DeClerck L, Löbmann K, Grohganz H, Rades T, Laitinen Riikka. 2015. Pharmazie. 70: 452-457

Monitoring of Drug Release Kinetics from Thin Polymer Films by Multi-Parametric Surface Plasmon Resonance

Korhonen Kristiina, Granqvist Niko, Ketolainen Jarkko, Laitinen Riikka. 2015. International journal of pharmaceutics. 494: 531-536

Amino acids as co-amorphous excipients for simvastatin and glibenclamide: physical properties and stability

Laitinen Riikka, Löbmann Korbinian, Grohganz Holger, Strachan Clare, Rades Thomas. 2014. Molecular pharmaceutics. 11: 2381-2389

Amino acids as co-amorphous stabilizers for poorly water soluble drugs - Part 1: Preparation, stability and dissolution enhancement

Löbmann Korbinian, Grohganz Holger, Laitinen Riikka, Strachan Clare, Rades Thomas. 2013. European journal of pharmaceutics and biopharmaceutics. 85: 873-881

Amino acids as co-amorphous stabilizers for poorly water-soluble drugs - Part 2: Molecular interactions

Löbmann Korbinian, Laitinen Riikka, Strachan Clare, Rades Thomas, Grohganz Holger. 2013. European journal of pharmaceutics and biopharmaceutics. 85: 882-888

Emerging trends in the stabilization of amorphous drugs

Laitinen Riikka, Löbmann Korbinian, Strachan Clare J, Grohganz Holger, Rades Thomas. 2013. International journal of pharmaceutics. 453: 65-79

Farmasian teknologia ja biofarmasia - uusia teknologioita lääkekehitykseen monitieteellisellä yhteistyöllä

Laitinen Riikka, Honkakoski Paavo, Järvinen Kristiina, Ketolainen Jarkko. Teoksessa: Ahonen R, Laitinen K, Lapinjoki S, Mensalo P, Ranta V-P, Ylikangas H (toim).(toim.) , 2013. Muutosten vuosikymmen : Itä-Suomen yliopiston farmasian laitos 40 vuotta. s. 24-30.

In situ amorphisation of indomethacin with Eudragit® E during dissolution

Priemel Petra A, Laitinen Riikka, Grohganz Holger, Rades Thomas, Strachan Clare J. 2013. European journal of pharmaceutics and biopharmaceutics. 85: 1259-1265

Inhibition of surface crystallisation of amorphous indomethacin particles in physical drug-polymer mixtures

Priemel Petra A, Laitinen Riikka, Barthold Sarah, Grohganz Holger, Lehto Vesa-Pekka, Rades Thomas, Strachan Clare J. 2013. International journal of pharmaceutics. 456: 301-306

Co-amorphous simvastatin and glipizide combinations show improved physical stability without evidence of intermolecular interactions

Löbmann Korbinian, Strachan Clare, Grohganz Holger, Rades Thomas, Korhonen Ossi, Laitinen Riikka. 2012. European journal of pharmaceutics and biopharmaceutics. 81: 159-169

PROMIS Centre - innovative pharmaceutical manufacturing research and technology development in Kuopio, Finland

Simonaho Simo-Pekka, Laitinen Riikka, Rimpiläinen Ville, Heikkinen Lasse, Vauhkonen Marko, Paaso Janne, Juuti Mikko, Ketolainen Jarkko. 2012. Dosis. 28: 251-260

Similar molecular descriptors determine the in vitro drug permeability in endothelial and epithelial cells

Hakkarainen Jenni J, Pajander Jari, Laitinen Riikka, Suhonen Marjukka, Forsberg Markus M. 2012. International journal of pharmaceutics. 436: 426-443

Coamorphous drug systems: enhanced physical stability and dissolution rate of indomethacin and naproxen

Löbmann Korbinian, Laitinen Riikka, Grohganz Holger, Gordon Keith C, Strachan Clare, Rades Thomas. 2011. Molecular pharmaceutics. 8: 1919-1928

Fast-dissolving sublingual solid dispersion and cyclodextrin complex increase the absorption of perphenazine in rabbits

Turunen Elina, Mannila Janne, Laitinen Riikka, Riikonen Joakim, Lehto Vesa-Pekka, Järvinen Tomi, Ketolainen Jarkko, Järvinen Kristiina, Jarho Pekka. 2011. Journal of pharmacy and pharmacology. 63: 19 - 25

Taking PAT to the next level

Ciurczak Emil, Ketolainen Jarkko, Laitinen Riikka, Aaltonen Jaakko, Lindén Hans. 2011. European journal of pharmaceutical sciences. 42: 1-2

An optical method for continuous monitoring of the dissolution rate of pharmaceutical powders

Laitinen R, Lahtinen J, Silfsten P, Vartiainen E, Jarho P & Ketolainen J. 2010. Journal of pharmaceutical and biomedical analysis. 52: 181 - 189

Perphenazine solid dispersions for orally fast-disintegrating tablets: physical stability and formulation

Laitinen R, Suihko E, Bjorkqvist M, Riikonen J, Lehto V-P, Jarvinen K & Ketolainen J. 2010. Drug development and industrial pharmacy. 36: 601 - 613

Intraorally fast-dissolving particles of a poorly soluble drug: Preparation and in vitro characterization

Laitinen R, Suihko E, Toukola K, Björkqvist M, Riikonen J, Lehto V-P, Järvinen K, Ketolainen J. 2009. European journal of pharmaceutics and biopharmaceutics. 71: 271-281

Physical Modification of Drug Release Controlling Structures : Hydrophobic Matrices and Fast Dissolving Particles

Laitinen R. 2009. Kuopion yliopiston julkaisuja A. Farmaseuttiset tieteet

Modifying drug release and tablet properties of starch acetate tablets by dry powder agglomeration

Mäki R, Suihko E, Rost S, Heiskanen M, Murtomaa M, Lehto V-P, Ketolainen J. 2007. Journal of pharmaceutical sciences. 96: 438-447

Controlled release of saccharides from matrix tablets

Mäki R, Suihko E, Korhonen O, Pitkänen H, Niemi R, Lehtonen M, Ketolainen J. 2006. European journal of pharmaceutics and biopharmaceutics. 62: 163-170

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Research groups

From waste to a resource? Hemicelluloses enhance the dissolution and stability of the amorphous state of carbamazepine

Farmasian teknologia ja biofarmasia

PE and PET oligomers’ interplay with membrane bilayers

Production and characterization of glibenclamide incorporated PLA filaments for 3D printing by fused deposition modeling

Co-Amorphous Formulations of Furosemide with Arginine and P-Glycoprotein Inhibitor Drugs

Preparation and characterization of hot-melt extruded polycaprolactone-based filaments intended for 3D-printing of tablets

Dissolution and permeability properties of co-amorphous formulations of hydrochlorothiazide

The effect of co-amorphization of glibenclamide on its dissolution properties and permeability through an MDCKII-MDR1 cell layer

Permeability of glibenclamide through a PAMPA membrane: the effect of co-amorphization

Preparation and characterization of multi-component tablets containing co-amorphous salts: combining multimodal non-linear optical imaging with established analytical methods

Effect of storage on the physical stability of thin polymethacrylate-perphenazine films

Reflectometric monitoring of the dissolution process of thin polymeric films

Spray drying of poorly soluble drugs from aqueous arginine solution

Supersaturating drug delivery systems: the potential of co-amorphous drug formulations

Dissolution behavior of co-amorphous amino acid-indomethacin mixtures: The ability of amino acids to stabilize the supersaturated state of indomethacin

Rational excipient selection for co-amorphous formulations

Systematic evaluation of a spraying method for preparing thin Eudragit-drug films by Design of Experiments

Characterization of Amorphous and Co-Amorphous Simvastatin Formulations Prepared by Spray Drying

Dissolution properties of co-amorphous drug-amino acid formulations in buffer and biorelevant media

Monitoring of Drug Release Kinetics from Thin Polymer Films by Multi-Parametric Surface Plasmon Resonance

Amino acids as co-amorphous excipients for simvastatin and glibenclamide: physical properties and stability

Pharmaceutical solids and processes

Refining stability and dissolution rate of amorphous drug formulations

A theoretical and spectroscopic study of co-amorphous naproxen and indomethacin

Amino acids as co-amorphous stabilizers for poorly water soluble drugs - Part 1: Preparation, stability and dissolution enhancement

Amino acids as co-amorphous stabilizers for poorly water-soluble drugs - Part 2: Molecular interactions

Emerging trends in the stabilization of amorphous drugs

Farmasian teknologia ja biofarmasia - uusia teknologioita lääkekehitykseen monitieteellisellä yhteistyöllä

In situ amorphisation of indomethacin with Eudragit® E during dissolution

Inhibition of surface crystallisation of amorphous indomethacin particles in physical drug-polymer mixtures

Co-amorphous simvastatin and glipizide combinations show improved physical stability without evidence of intermolecular interactions

PROMIS Centre - innovative pharmaceutical manufacturing research and technology development in Kuopio, Finland

Similar molecular descriptors determine the in vitro drug permeability in endothelial and epithelial cells

Coamorphous drug systems: enhanced physical stability and dissolution rate of indomethacin and naproxen

Fast-dissolving sublingual solid dispersion and cyclodextrin complex increase the absorption of perphenazine in rabbits

Taking PAT to the next level

An optical method for continuous monitoring of the dissolution rate of pharmaceutical powders

Perphenazine solid dispersions for orally fast-disintegrating tablets: physical stability and formulation

Intraorally fast-dissolving particles of a poorly soluble drug: Preparation and in vitro characterization

Physical Modification of Drug Release Controlling Structures : Hydrophobic Matrices and Fast Dissolving Particles

Modifying drug release and tablet properties of starch acetate tablets by dry powder agglomeration

Controlled release of saccharides from matrix tablets