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Risto Juvonen

Risto Juvonen

Senior Researcher

School of Pharmacy, Faculty of Health Sciences

risto.juvonen@uef.fi | +358 40 728 2699

Information Publications

Research groups

Metabolism and transport of drugs and xenobiotics 01.01.2010 -
Toxicology Research Group 01.03.2014 -

Publications

123/123 items

Alkoholien toksikokinetiikka
Juvonen, Risto; Savolainen, Kai; Kärkkäinen, Olli. Teoksessa: Ruskoaho, Heikki; Hakkola, Jukka; Kantele, Anu; Korpi, Esa R; Moilanen, Eeva; Piepponen, Petteri; Rysä, Jaana; Savontaus, Eriika; Tenhunen, Olli(toim.) , 2024. Lääketieteellinen farmakologia ja toksikologia. s. 1313-1314. Kustannus Oy Duodecim
Alkoholimyrkytyskuolemat ja alkoholille altistuminen
Juvonen, Risto; Savolainen, Kai; Kärkkäinen, Olli. Teoksessa: Ruskoaho, Heikki; Hakkola, Jukka; Kantele, Anu; Korpi, Esa R; Moilanen, Eeva; Piepponen, Petteri; Rysä, Jaana; Savontaus, Eriika; Tenhunen, Olli(toim.) , 2024. Lääketieteellinen farmakologia ja toksikologia. s. 1310-1313. Kustannus Oy Duodecim
Etanolimyrkytys
Juvonen, Risto; Savolainen, Kai; Kärkkäinen, Olli. Teoksessa: Ruskoaho, Heikki; Hakkola, Jukka; Kantele, Anu; Korpi, Esa R; Moilanen, Eeva; Piepponen, Petteri; Rysä, Jaana; Savontaus, Eriika; Tenhunen, Olli(toim.) , 2024. Lääketieteellinen farmakologia ja toksikologia. s. 1315. Kustannus Oy Duodecim
Etyleeniglykolimyrkytys
Juvonen, Risto; Savolainen, Kai; Kärkkäinen, Olli. Teoksessa: Ruskoaho, Heikki; Hakkola, Jukka; Kantele, Anu; Korpi, Esa R; Moilanen, Eeva; Piepponen, Petteri; Rysä, Jaana; Savontaus, Eriika; Tenhunen, Olli(toim.) , 2024. Lääketieteellinen farmakologia ja toksikologia. s. 1317. Kustannus Oy Duodecim
Evaluation of Lippia scaberrima Sond. and Aspalathus linearis (Burm.f.) R. Dahlgren extracts on human CYP enzymes and gold nanoparticle synthesis: implications for drug metabolism and cytotoxicity
Kok, Anna-Mari; Juvonen, Risto; Pasanen, Markku; Mandiwana, Vusani; Kalombo, Michel Lonji; Ray, Suprakas Sinha; Rikhotso-Mbungela, Rirhandzu; Lall, Namrita. 2024. BMC complementary medicine and therapies. 24: . 152
Metanolimyrkytys
Juvonen, Risto; Savolainen, Kai; Kärkkäinen, Olli. Teoksessa: Ruskoaho, Heikki; Hakkola, Jukka; Kantele, Anu; Korpi, Esa R; Moilanen, Eeva; Piepponen, Petteri; Rysä, Jaana; Savontaus, Eriika; Tenhunen, Olli(toim.) , 2024. Lääketieteellinen farmakologia ja toksikologia. s. 1315-1316. Kustannus Oy Duodecim
Identification of Gut Microbial Lysine and Histidine Degradation and CYP-Dependent Metabolites as Biomarkers of Fatty Liver Disease
Driuchina, Anastasiia; Hintikka, Jukka; Lehtonen, Marko; Keski-Rahkonen, Pekka; O’Connell, Thomas; Juvonen, Risto; Kuula, Juho; Hakkarainen, Antti; Laukkanen, Jari A; Mäkinen, Elina; Lensu, Sanna; Pietiläinen, Kirsi H; Pekkala, Satu. 2023. Mbio. 14: . e02663-22
Western Diet Decreases Hepatic Drug Metabolism in Male LDLr−/−ApoB100/100 Mice
Koponen, Markus; Rysä, Jaana; Ruotsalainen, Anna-Kaisa; Kärkkäinen, Olli; Juvonen, Risto O. 2023. Journal of nutrition and metabolism. 2023:
A Comprehensive Evaluation of Sdox, a Promising H2S-Releasing Doxorubicin for the Treatment of Chemoresistant Tumors
Alov, Petko; Al Sharif, Merilin; Aluani, Denitsa; Chegaev, Konstantin; Dinic, Jelena; Divac Rankov, Aleksandra; Fernandes, Miguel X.; Fusi, Fabio; García-Sosa, Alfonso T.; Juvonen, Risto; Kondeva-Burdina, Magdalena; Padrón, José M.; Pajeva, Ilza; Pencheva, Tania; Puerta, Adrián; Raunio, Hannu; Riganti, Chiara; Tsakovska, Ivanka; Tzankova, Virginia; Yordanov, Yordan; Saponara, Simona. 2022. Frontiers in pharmacology. 13: . 831791
In vitro metabolism of helenalin and its inhibitory effect on human cytochrome P450 activity
Šadibolová, Michaela; Juvonen, Risto O; Auriola, Seppo; Boušová, Iva. 2022. Archives of toxicology. 96: 793-808
Toxicological Information Literacy Protects Human Health
Juvonen, Risto O.; Laitinen, Heikki; Saarti, Jarmo. 2022. Science and technology libraries. 41: 422-431
Information literacy skills are required in finding reliable toxicological information resources
Laitinen, Heikki; Juvonen, Risto O; Saarti, Jarmo. 2021. Journal of the European association for health information and libraries. 17: 23-28
Molecular docking and oxidation kinetics of 3-phenyl coumarin derivatives by human CYP2A1
Juvonen, Risto O; Jokinen, Elmeri M; Huuskonen, Juhani; Kärkkäinen, Olli; Raunio, Hannu; Pentikäinen, Olli T. 2021. Xenobiotica. 51: 1207-1216
Substrate Selectivity of Coumarin Derivatives by Human CYP1 Enzymes: In Vitro Enzyme Kinetics and In Silico Modeling
Juvonen, Risto O; Ahinko, Mira; Jokinen, Elmeri M; Huuskonen, Juhani; Raunio, Hannu; Pentikäinen, Olli T. 2021. ACS omega. 6: 11286-11296
Activities of metabolizing enzymes in human placenta
Mohammed, Ali Mustafa; Huuskonen, Pasi; Juvonen, Risto; Sahlman, Heidi; Repo, Jenni; Myöhänen, Kirsi; Myllynen, Päivi; Woo, Chit-Shing Jackson; Karttunen, Vesa; Vähäkangas, Kirsi. 2020. Toxicology letters. 326: 70-77
Coumarin-Based Profluorescent and Fluorescent Substrates for Determining Xenobiotic-Metabolizing Enzyme Activities In Vitro
Raunio, Hannu; Pentikäinen, Olli; Juvonen, Risto O. 2020. International journal of molecular sciences. 21: E4708
In vitro sulfonation of 7-hydroxycoumarin derivatives in liver cytosol of human and six animal species
Juvonen, RO; Pentikäinen, O; Huuskonen, J; Timonen, J; Kärkkäinen, O; Heikkinen, A; Fashe, M; Raunio, H. 2020. Xenobiotica. 50: 885-893
Inhibition of Human CYP1 Enzymes by a Classical Inhibitor α-Naphthoflavone and a Novel Inhibitor N-(3, 5- Dichlorophenyl)cyclopropanecarboxamide - An in Vitro and in Silico Study
Juvonen, RO; Jokinen, EM; Javaid, A; Lehtonen, M; Raunio, H; Pentikäinen, OT. 2020. Chemical biology and drug design. 95: 520-533
Physiological and toxicological considerations
Berglund, Larry G; Rissanen, Sirkka; Jussila, Kirsi; Kaufman, Jonathan W; Piirilä, Päivi; Savolainen, Kai M; Kalliokoski, Pentti; Pasanen, Pertti; Viluksela, Matti; Landström, Ulf; Saarinen, Pekka; Rysä, Jaana; Juvonen, Risto. Teoksessa: Goodfellow, Howard D; Kosonen, Risto(toim.) , 2020. Industrial Ventilation Design Guidebook Volume 1: Fundamentals. s. 111-226. Academic press
Tissue and interspecies comparison of catechol- O-methyltransferase mediated catalysis of 6- O-methylation of esculetin to scopoletin and its inhibition by entacapone and tolcapone
Jalkanen, Aaro; Lassheikki, Veera; Torsti, Tommi; Gharib, Elham; Lehtonen, Marko; Juvonen, Risto O. 2020. Xenobiotica. 2021; 51: 268-278
Alkoholien toksikokinetiikka
Juvonen, Risto; Savolainen, Kai. Teoksessa: Ruskoaho, Heikki; Hakkola, Jukka; Huupponen, Risto; Kantele, Anu; Korpi, Esa R; Moilanen, Eeva; Piepponen, Petteri; Savontaus, Eriika; Tenhunen, Olli; Vähäkangas, Kirsi(toim.) , 2019. Lääketieteellinen farmakologia ja toksikologia. s. 1160-1162. Kustannus Oy Duodecim
Alkoholimyrkytyskuolemat ja alkoholille altistuminen
Juvonen, Risto; Savolainen, Kai. Teoksessa: Ruskoaho, Heikki; Hakkola, Jukka; Huupponen, Risto; Kantele, Anu; Korpi, Esa R; Moilanen, Eeva; Piepponen, Petteri; Savontaus, Eriika; Tenhunen, Olli; Vähäkangas, Kirsi(toim.) , 2019. Lääketieteellinen farmakologia ja toksikologia. s. 1158-1160. Kustannus Oy Duodecim
Etanolimyrkytys
Juvonen, Risto; Savolainen, Kai. Teoksessa: Ruskoaho, Heikki; Hakkola, Jukka; Huupponen, Risto; Kantele, Anu; Korpi, Esa R; Moilanen, Eeva; Piepponen, Petteri; Savontaus, Eriika; Tenhunen, Olli; Vähäkangas, Kirsi(toim.) , 2019. Lääketieteellinen farmakologia ja toksikologia. s. 1162-1163. Kustannus Oy Duodecim
Etyleeniglykolimyrkytys
Juvonen, Risto; Savolainen, Kai. Teoksessa: Ruskoaho, Heikki; Hakkola, Jukka; Huupponen, Risto; Kantele, Anu; Korpi, Esa R; Moilanen, Eeva; Piepponen, Petteri; Savontaus, Eriika; Tenhunen, Olli; Vähäkangas, Kirsi(toim.) , 2019. Lääketieteellinen farmakologia ja toksikologia. s. 1164. Kustannus Oy Duodecim
In Vitro Human Metabolism and Inhibition Potency of Verbascoside for CYP Enzymes
Reid, AM; Juvonen, R; Huuskonen, P; Lehtonen, M; Pasanen, M; Lall, N. 2019. Molecules. 24: 2191
In vitro glucuronidation of 7-hydroxycoumarin derivatives in intestine and liver microsomes of Beagle dogs
Juvonen, Risto O; Heikkinen, Aki T; Kärkkäinen, Olli; Jehangir, Rabia; Huuskonen, Juhani; Troberg, Johanna; Raunio, Hannu; Pentikäinen, Olli T; Finel, Moshe. 2019. European journal of pharmaceutical sciences. 141: 105118
Metabolism of Scoparone in Experimental Animals and Humans
Juvonen, RO; Novák, F; Emmanouilidou, E; Auriola, S; Timonen, J; Heikkinen, AT; Küblbeck, J; Finel, M; Raunio, H. 2019. Planta medica. 85: 453-464
Metanolimyrkytys
Juvonen, Risto; Savolainen, Kai. Teoksessa: Ruskoaho, Heikki; Hakkola, Jukka; Huupponen, Risto; Kantele, Anu; Korpi, Esa R; Moilanen, Eeva; Piepponen, Petteri; Savontaus, Eriika; Tenhunen, Olli; Vähäkangas, Kirsi(toim.) , 2019. Lääketieteellinen farmakologia ja toksikologia. s. 1163-1164. Kustannus Oy Duodecim
Blocking oestradiol synthesis pathways with potent and selective coumarin derivatives
Niinivehmas, S; Postila, PA; Rauhamäki, S; Manivannan, E; Kortet, S; Ahinko, M; Huuskonen, P; Nyberg, N; Koskimies, P; Lätti, S; Multamäki, E; Juvonen, RO; Raunio, H; Pasanen, M; Huuskonen, J; Pentikäinen, OT. 2018. Journal of enzyme inhibition and medicinal chemistry. 33: 743-754
Development of New Coumarin-Based Profluorescent Substrates for Human Cytochrome P450 Enzymes
Juvonen, Risto O; Ahinko, Mira; Huuskonen, Juhani; Raunio, Hannu; Pentikäinen, Olli T. 2018. Xenobiotica. 49: 1015-1024
Making it Together: Information Specialist and Toxicologist Developing Students' Professional Information Skills (Abstract)
Laitinen, Heikki; Juvonen, Risto O; Saarti, Jarmo. 2018. Oulun yliopisto
Molecular Docking-Based Design and Development of a Highly Selective Probe Substrate for UDP-glucuronosyltransferase 1A10
Juvonen, RO; Rauhamäki, S; Kortet, S; Niinivehmas, S; Troberg, J; Petsalo, A; Huuskonen, J; Raunio, H; Finel, M; Pentikäinen, OT. 2018. Molecular pharmaceutics. 15: 923-933
New glutathione conjugate of the pyrrolizidine alkaloids produced by human cytosolic enzyme dependent reactions in vitro
Muluneh, Fashe; Häkkinen, Merja R; El Dairi, Rami; Pasanen, Markku; Juvonen, Risto O. 2018. Rapid communications in mass spectrometry. 32: 1344-1352
Structure-Activity Relationship Analysis of 3-Phenylcoumarin-Based Monoamine Oxidase B Inhibitors
Rauhamaki, Sanna; Postila, Pekka A; Niinivehmas, Sanna; Kortet, Sami; Schildt, Emmi; Pasanen, Mira; Manivannan, Elangovan; Ahinko, Mira; Koskimies, Pasi; Nyberg, Niina; Huuskonen, Pasi; Multamaki, Elina; Pasanen, Markku; Juvonen, Risto O; Raunio, Hannu; Huuskonen, Juhani; Pentikainen, Olli T. 2018. Frontiers in chemistry. 6: 41
Comparison of In Vitro Hepatic Scoparone 7-O-Demethylation between Humans and Experimental Animals
Fayyaz A, Makwinja S, Auriola S, Raunio H, Juvonen R. 2017. Planta medica. 2018; 84: 320-328
Common and Distinct Interactions of Chemical Inhibitors with Cytochrome P450 CYP1A2, CYP2A6 and CYP2B6 Enzymes
Raunio Hannu, Juvonen Risto O, Poso Antti, Lahtela-Kakkonen Maija, Rahnasto-Rilla Minna. 2016. Drug metabolism letters. 10: 56-64
Comparison of trapping profiles between d-peptides and glutathione in the identification of reactive metabolites
Laine Jaana E, Häkkinen Merja R, Auriola Seppo, Juvonen Risto O, Pasanen Markku. 2015. Toxicology reports. 2: 1024-1032
Discovery of urinary biomarkers of whole grain rye intake in free-living subjects using non-targeted LC-MS metabolite profiling
Hanhineva Kati, Brunius Carl, Andersson Agneta, Marklund Matti, Juvonen Risto, Keski-Rahkonen Pekka, Auriola Seppo, Landberg Rikard. 2015. Molecular nutrition and food research. [epub ahead of print 10 SEP 2015]: -
In Silico Prediction of the Site of Oxidation by Cytochrome P450 3A4 That Leads to the Formation of the Toxic Metabolites of Pyrrolizidine Alkaloids
Fashe Muluneh M, Juvonen Risto O, Petsalo Aleksanteri, Vepsäläinen Jouko, Pasanen Markku, Rahnasto-Rilla Minna. 2015. Chemical research in toxicology. 28: 702-710
Inhibitory effects and oxidation of 6-methylcoumarin, 7-methylcoumarin and 7-formylcoumarin via human CYP2A6 and its mouse and pig orthologous enzymes
Juvonen Risto O, Kuusisto Mira, Fohrgrup Carolin, Pitkänen Mari H, Nevalainen Tapio J, Auriola Seppo, Raunio Hannu, Pasanen Markku, Pentikäinen Olli T. 2015. Xenobiotica. 2016; 46: 14-24
Modeling of interactions between xenobiotics and cytochrome P450 (CYP) enzymes
Raunio Hannu, Kuusisto Mira, Juvonen Risto O, Pentikäinen Olli T. 2015. Frontiers in pharmacology. 6: 123
Species-specific differences in the in vitro metabolism of lasiocarpine
Fashe Muluneh M, Juvonen Risto O, Petsalo Aleksanteri, Räsänen Juha, Pasanen Markku. 2015. Chemical research in toxicology. 28: 2034-2044
Alkoholimyrkytykset ja alkoholin krooniset haitat [Luku 43]
Juvonen Risto, Savolainen Kai, Vähäkangas Kirsi. Teoksessa: Pelkonen Olavi, Ruskoaho Heikki, Hakkola Jukka, Huupponen Risto, MacDonald Ewen, Moilanen Eeva, Pasanen Markku, Scheinin Mika, Vähäkangas Kirsi(toim.) , 2014. Lääketieteellinen farmakologia ja toksikologia. s. 1044-1054. Kustannus Oy Duodecim
Chloropicrin-induced toxic responses in human lung epithelial cells
Pesonen Maija, Häkkinen Merja, Rilla Kirsi, Juvonen Risto, Kuitunen Tapio, Pasanen Markku, Vähäkangas Kirsi. 2014. Toxicology letters. 226: 236-244
Identification of a New Reactive Metabolite of Pyrrolizidine Alkaloid Retrorsine: (3H-Pyrrolizin-7-yl)methanol
Fashe Muluneh M, Juvonen Risto O, Petsalo Aleksanteri, Rahnasto-Rilla Minna, Auriola Seppo, Soininen Pasi, Vepsäläinen Jouko, Pasanen Markku. 2014. Chemical research in toxicology. 27: 1950-1957
Lasten lääkekasvatus
Keinonen Tuula, Hartikainen-Ahia Anu, Hokkanen Johanna, Hämeen-Anttila Katri, Juvonen Risto, Kosonen Anna-Liisa, Kärkkäinen Sirpa, Siitonen Piia, Vainio Kirsti. 2014. Dosis. 30: 237
Preclinical pharmacology of FL442, a novel nonsteroidal androgen receptor modulator
Poutiainen Pekka K, Huhtala Tuulia, Jääskeläinen Tiina, Petsalo Aleksanteri, Küblbeck Jenni, Kaikkonen Sanna, Palvimo Jorma J, Raunio Hannu, Närvänen Ale, Peräkylä Mikael, Juvonen Risto O, Honkakoski Paavo, Laatikainen Reino, Pulkkinen Juha T. 2014. Molecular and cellular endocrinology. 387: 8-18
Quantitative ADME Proteomics - CYP and UGT Enzymes in the Beagle Dog Liver and Intestine
Heikkinen Aki T, Friedlein Arno, Matondo Mariette, Hatley Oliver J, Petsalo Aleksanteri, Juvonen Risto, Galetin Aleksandra, Rostami-Hodjegan Amin, Aebersold Ruedi, Lamerz Jens, Dunkley Tom, Cutler Paul, Parrott Neil. 2014. Pharmaceutical research. 2015; 32: 74-90
Rational design of novel CYP2A6 inhibitors
Tani Niina, Juvonen Risto O, Raunio Hannu, Fashe Muluneh, Leppänen Jukka, Zhao Bin, Tyndale Rachel F, Rahnasto-Rilla Minna. 2014. Bioorganic and medicinal chemistry. 22: 6655-6664
Reactive Metabolites in Early Drug Development: Predictive in Vitro Tools
Pelkonen Olavi, Pasanen Markku, Tolonen Ari, Koskinen Mikko, Hakkola Jukka, Abass Khaled, Laine Jaana, Häkkinen Merja, Juvonen Risto, Auriola Seppo, Storvik Markus, Huuskonen Pasi, Rousu Timo, Rahikkala Maiju. 2014. Current medicinal chemistry. 2015; 22: 538-550
Vierasaineiden metabolia
Raunio Hannu, Pasanen Markku, Juvonen Risto, Rahnasto-Rilla Minna, Tani Niina, Hukkanen Kaisa, Huuskonen Pasi, Muluneh Fashe. 2014. Dosis. 30: 208
A high throughput assay for the glucuronidation of 7-hydroxy-4-trifluoromethylcoumarin by recombinant human UDP-glucuronosyltransferases and liver microsomes
Rahikainen Tuomas, Häkkinen Merja R, Finel Moshe, Pasanen Markku, Juvonen Risto O. 2013. Xenobiotica. 43: 853-861
Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system
Pimkaew Prapapan, Küblbeck Jenni, Petsalo Aleksanteri, Jukka Jouni, Suksamrarn Apichart, Juvonen Risto, Auriola Seppo, Piyachaturawat Pawinee, Honkakoski Paavo. 2013. Toxicology in vitro. 27: 2005-2012
Yleisen toksikologian kansainvälisen maisteriohjelman kehittyminen - tieteellinen tutkimus opetuksen perustana
Vähäkangas Kirsi, Pasanen Markku, Raunio Hannu, Mensalo Päivi, Juvonen Risto, Loikkanen Jarkko. Teoksessa: Ahonen R, Laitinen K, Lapinjoki S, Mensalo P, Ranta V-P, Ylikangas H (toim).(toim.) , 2013. Muutosten vuosikymmen : Itä-Suomen yliopiston farmasian laitos 40 vuotta. s. 48-53.
Aldehyde dehydrogenase inhibitors: a comprehensive review of the pharmacology, mechanism of action, substrate specificity, and clinical application
Koppaka Vindhya, Thompson David C, Chen Ying, Ellermann Manuel, Nicolaou Kyriacos C, Juvonen Risto O, Petersen Dennis, Deitrich Richard A, Hurley Thomas D, Vasiliou Vasilis. 2012. Pharmacological reviews. 64: 520-539
Antifungal activities of novel non-azole molecules against S. cerevisiae and C. albicans
Tani Niina, Rahnasto-Rilla Minna, Wittekindt Carsten, Salminen Kaisa A, Ritvanen Anniina, Ollakka Riina, Koskiranta Jenna, Raunio Hannu, Juvonen Risto O. 2012. European journal of medicinal chemistry. 47: 270-277
ApoE3 mediated polymeric nanoparticles containing curcumin: Apoptosis induced in vitro anticancer activity against neuroblastoma cells
Mulik Rohit S, Mönkkönen Jukka, Juvonen Risto O, Mahadik Kakasaheb R, Paradkar Anant R. 2012. International journal of pharmaceutics. 437: 29-41
Apoptosis-induced anticancer effect of transferrinconjugated solid lipid nanoparticles of curcumin
Mulik Rohit S, Mönkkönen Jukka, Juvonen Risto O, Mahadik Kakasaheb R, Paradkar Anant R. 2012. Cancer nanotechnology. 3: 65-81
Comparison of Electrochemical and Biological Oxidation of Pyrrolizidine Alkaloid Retrorsine
Fashe Muluneh, Petsalo Aleksanteri, Juvonen Risto O, Rahnasto-Rilla Minna, Pasanen Markku, Auriola Seppo. 2012. Dosis
Design, synthesis, and evaluation of novel cyclic phosphates of 5-aminosalicylic acid as cytochrome P450-activated prodrugs
Huttunen Kristiina M, Tani Niina, Juvonen Risto O, Raunio Hannu, Rautio Jarkko. 2012. Molecular pharmaceutics. 2013:10: 532-537
Function and regulation of the Cyp2a5/CYP2A6 genes in response to toxic insults in the liver
Abu-Bakar A'edah, Hakkola Jukka, Juvonen Risto, Rahnasto-Rilla Minna, Raunio Hannu, Lang Matti A. 2012. Current drug metabolism. 2013:14: 137-150
Interactions of inhibitor molecules with the human CYP2E1 enzyme active site
Martikainen Laura E, Rahnasto-Rilla Minna, Neshybova Silvie, Lahtela-Kakkonen Maija, Raunio Hannu, Juvonen Risto O. 2012. European journal of pharmaceutical sciences. 47: 996-1005
Metabolism of bilirubin by human cytochrome P450 2A6
Abu-Bakar A'edah, Arthur Dionne M, Wikman Anna S, Rahnasto Minna, Juvonen Risto O, Vepsäläinen Jouko, Raunio Hannu, Ng Jack C, Lang Matti A. 2012. Toxicology and applied pharmacology. 261: 50-58
2'-Deoxyguanosine as a surrogate trapping agent for DNA reactive drug metabolites
Häkkinen Merja R, Laine Jaana E, Juvonen Risto O, Auriola Seppo, Häyrinen Jukka, Pasanen Markku. 2011. Toxicology letters. 207: 34-41
Identification of novel CYP2A6 inhibitors by virtual screening
Rahnasto Minna K, Raunio Hannu A, Wittekindt Carsten, Salminen Kaisa A, Leppänen Jukka, Juvonen Risto O, Poso Antti, Lahtela-Kakkonen Maija K. 2011. Bioorganic and medicinal chemistry. 19: 7186-7193
Inhibition of human drug metabolizing cytochrome P450 enzymes by plant isoquinoline alkaloids
Salminen Kaisa A, Meyer Achim, Jerabkova Lenka, Korhonen Laura E, Rahnasto Minna, Juvonen Risto O, Imming Peter, Raunio Hannu. 2011. Phytomedicine. 18: 533 - 538
Simple, direct, and informative method for the assessment of CYP2C19 enzyme inactivation kinetics
Salminen Kaisa A, Leppänen Jukka, Venäläinen Jarkko I, Pasanen Markku, Auriola Seppo, Juvonen Risto O, Raunio Hannu. 2011. Drug metabolism and disposition. 39: 412 - 418
d-Isomer of gly-tyr-pro-cys-pro-his-pro peptide: A novel and sensitive in vitro trapping agent to detect reactive metabolites by electrospray mass spectrometry
Laine Jaana, Auriola Seppo, Pasanen Markku, Juvonen Risto. 2011. Toxicology in vitro. 25: 411 - 425
ApoE3 mediated poly(butyl) cyanoacrylate nanoparticles containing curcumin: study of enhanced activity of curcumin against beta amyloid induced cytotoxity using in vitro cell culture model
Mulik RS, Mönkkönen J, Juvonen RO, Mahadik KR & Paradkar AR. 2010. Molecular pharmaceutics. 7: 815-825
Mitä haittoja sienet voivat aiheuttaa? (Kuukauden kysymys)
Juvonen R. 2010. APTEEKKARI: SUOMEN APTEEKKARILEHTI. : 26-28
Transferrin mediated solid lipid nanoparticles containing curcumin: Enhanced in vitro anticancer activity by induction of apoptosis
Mulik RS, Mönkkönen J, Juvonen RO, Mahadik KR & Paradkar AR. 2010. International journal of pharmaceutics. 398: 190-203
Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes
Laine JE, Auriola S, Pasanen M, Juvonen RO. 2009. Xenobiotica. 39: 11-21
Teaching about intoxicating substances in primary school: teacher students' thoughts on the subject
Kärkkäinen S, Keinonen T, Juvonen R. 2009. . 11: 78-85
Identification of inhibitors of the nicotine metabolising CYP2A6 enzyme-an in silico approach
Rahnasto M, Wittekindt C, Juvonen RO, Turpeinen M, Petsalo A, Pelkonen O, Poso A, Stahl G, Höltje H-D, Raunio H. 2008. Pharmacogenomics journal. 8: 328-338
Nicotine metabolism and urinary elimination in mouse: in vitro and in vivo
Raunio H, Pokela N, Puhakainen K, Rahnasto M, Mauriala T, Auriola S, Juvonen RO. 2008. Xenobiotica. 38: 34-47
Lactobacillus rhamnosus strain GG reduces aflatoxin B1 transport, metabolism, and toxicity in Caco-2 cells
Gratz S, Wu QK, El-Nezami H, Juvonen RO, Mykkänen H, Turner PC, Gratz S, WU QK, El-Nezami H. 2007. Applied and environmental microbiology. 73: 3958-3964
New potent and selective cytochrome P450 2B6 (CYP2B6) inhibitors based on three-dimensional quantitative structure-activity relationship (3D-QSAR) analysis
Korhonen LE, Turpeinen M, Rahnasto M, Wittekindt C, Poso A, Pelkonen O, Raunio H, Juvonen RO. 2007. British journal of pharmacology. 150: 932-942
Novel cyclic phosphate prodrug approach for cytochrome P450-activated drugs containing an alcohol functionality
Huttunen KM, Mähönen N, Leppänen J, Vepsäläinen J, Juvonen RO, Raunio H, Kumpulainen H, Järvinen T, Rautio J. 2007. Pharmaceutical research. 24: 679-687
Cytochrome P450 (CYP) inhibition screening: Comparison of three tests
Turpeinen M, Korhonen LE, Tolonen A, Uusitalo J, Juvonen R, Raunio H, Pelkonen O. 2006. European journal of pharmaceutical sciences. 29: 130-138
Evaluation of hydroxyimine as cytochrome P450-selective prodrug structure
Kumpulainen H, Mähönen N, Laitinen M-L, Jaurakkajärvi M, Raunio H, Juvonen RO, Vepsäläinen J, Järvinen T, Rautio J. 2006. Journal of medicinal chemistry. 49: 1207-1211
Fatty acid amide hydrolase inhibitors from virtual screening of the endocannabinoid system
Saario SM, Poso A, Juvonen RO, Järvinen T, Salo-Ahen OMH. 2006. Journal of medicinal chemistry. 49: 4650-4656
Lactobacillus rhamnosus strain GG modulates intestinal absorption, fecal excretion, and toxicity of aflatoxin B1 in rats
Gratz S, Täubel M, Juvonen RO, Viluksela M, Turner PC, Mykkänen H, El-Nezami H, Gratz S, Täubel M, El-Nezami H. 2006. Applied and environmental microbiology. 72: 7398-7400
Probiotic supplementation reduces a biomarker for increased risk of liver cancer in young men from Southern China
El-Nezami HS, Polychronaki NN, Ma J, Zhu H, Ling W, Salminen EK, Juvonen RO, Salminen SJ, Poussa T, Mykkänen HM, El-Nezami HS, Polychronaki NN, Mykkänen HM. 2006. American journal of clinical nutrition. 83: 1199-1203
Fecal and urinary excretion of aflatoxin B1 metabolites (AFQ1, AFM1 and AFB-N7-guanine) in young Chinese males
Mykkänen H, Zhu H, Salminen E, Juvonen RO, Ling W, Ma J, Polychronaki N, Kemiläinen H, Mykkänen O, Salminen S, El-Nezami H, Mykkänen H, Polychronaki, Kemiläinen H, Mykkänen O, El-Nezami H. 2005. International journal of cancer. 115: 879-884
Predictive three-dimensional quantitative structure-activity relationship of cytochrome P450 1A2 inhibitors
Korhonen LE, Rahnasto M, Mähönen N J, Wittekindt C, Poso A, Juvonen RO, Raunio H. 2005. Journal of medicinal chemistry. 48: 3808-3815
Quantitative structure - activity relationship analysis of inhibitors of the nicotine metabolizing CYP2A6 enzyme
Rahnasto M, Raunio H, Poso A, Wittekindt C, Juvonen RO. 2005. Journal of medicinal chemistry. 48: 440-449
Suippumyrkkyseitikkimyrkytys
Seppänen J, Juvonen R. 2005. SIENILEHTI. 57: 108-116
Evolutionary relationships of the prolyl oligopeptidase family enzymes
Venäläinen JI, Juvonen RO, Männistö PT. 2004. Febs journal. 271: 2705-2715
In vitro methods in the prediction of kinetics of drugs: focus on drug metabolism
Raunio H, Taavitsainen P, Honkakoski P, Juvonen R, Pelkonen O. 2004. Atla: alternatives to laboratory animals. 32: 425-430
Interaktiivisen opetuksen kehittämisestä systemaattisen farmakologian ja lääkeainetoksikologian kurssilla
Turrek M, Juvonen RO, Ripatti I, Männistö PT, Raasmaja A. 2004. Dosis. 20: 201-208
Intestinal mucus alters the ability of probiotic bacteria to bind aflatoxin B1 in vitro
Gratz S, Mykkänen H, Ouwehand AC, Juvonen R, Salminen S, El-Nezami H, Gratz S, El-Nezami H. 2004. Applied and environmental microbiology. 70: 6306-6308
Lack of increased oxidative stress in catechol-O-methyltransferase (COMT)-deficient mice
Forsberg MM, Juvonen RO, Helisalmi P, Leppänen J, Gogos JA, Karayiorgou M, Männistö PT. 2004. Naunyn-schmiedebergs archives of pharmacology. 370: 279-289
Slow-binding inhibitors of prolyl oligopeptidase with different functional groups at the P1 site
Venäläinen JI, Juvonen RO, Garcia-Horsman JA, Wallen EAA, Christiaans JAM, Jarho EM, Gynther J, Männistö PT. 2004. Biochemical journal. 382: 1003-1008
More potent inhibition of human CYP2A6 than mouse CYP2A5 enzyme activities by derivatives of phenylethylamine and benzaldehyde
Rahnasto M, Raunio H, Poso A, Juvonen RO. 2003. Xenobiotica. 33: 529-539
Predictive value of comparative molecular field analysis modelling of naphthalene inhibition of human CYP2A6 and mouse CYP2A5 enzymes
Asikainen A, Tarhanen J, Poso A, Pasanen M, Alhava E, Juvonen RO. 2003. Toxicology in vitro. 17: 449-455
Psilosybiini huumaavien sienten vaikuttava myrkky
Myöhänen T, Juvonen R. 2003. SIENILEHTI. 55: 36-46
Comparison of acute toxicities of indolo(3,2-b)carbazole (ICZ) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in TCDD-sensitive rats
Pohjanvirta R, Korkalainen M, McGuire J, Simanainen U, Juvonen R, Tuomisto JT, Unkila M, Viluksela M, Bergman J, Poellinger L, Tuomisto J. 2002. Food and chemical toxicology. 40: 1023-1032
Reduced natriuretic response to acute sodium loading in COMT gene deleted mice [online]
Odlind C, Reenilä I, Männistö PT, Juvonen R, Uhlén S, Gogos JA, Karayiorgou M, Hansell P. 2002. Bmc physiology. 2:
Substrate-dependent, non-hyperbolic kinetics of pig brain prolyl oligopeptidase and its tight binding inhibition by JTP-4819
Venäläinen JI, Juvonen RO, Forsberg MM, Garcia-Horsman A, Poso A, Wallen EAA, Gynther J, Männistö PT. 2002. Biochemical pharmacology. 64: 463-471
A comparative molecular field analysis of cytochrome P450 2A5 and 2A6 inhibitors
Poso A, Gynther J, Juvonen R. 2001. Journal of computer-aided molecular design. 15: 195-202
In vitro inhibition of cytochrome P450 enzymes in human liver microsomes by a potent CYP2A6 inhibitor, trans-2-phenylcyclopropylamine (tranylcypromine), and its nonamine analog, cyclopropylbenzene
Taavitsainen P, Juvonen R, Pelkonen O. 2001. Drug metabolism and disposition. 29: 217-222
Cytochromes P450 2A6, 2E1, and 3A and production of protein-aldehyde adducts in the liver of patients with alcoholic and non-alcoholic liver diseases
Niemelä O, Parkkila S, Juvonen RO, Viitala K, Gelboin HV, Pasanen M. 2000. Journal of hepatology. 33: 893-901
Kinetic characteristics of norcocaine N-hydroxylation in mouse and human liver microsomes: involvement of CYP enzymes
Pellinen P, Kulmala L, Konttila J, Auriola S, Pasanen M, Juvonen R. 2000. Archives of toxicology. 74: 511-520
Pronounced differences in inhibition potency of lactone and non-lactone compounds for mouse and human coumarin 7-hydroxylases (CYP2A5 and CYP2A6)
Juvonen RO, Gynther J, Pasanen M, Alhava E, Poso A. 2000. Xenobiotica. 30: 81-92
Cytochrome P4502A6 (CYP2A6) expression in human hepatocellular carcinoma
Raunio H, Juvonen R, Pasanen M, Pelkonen O, Pääkkö P, Soini Y. 1998. Hepatology. 27: 427-432
Induction of CYP2A5 by pyrazole and its derivatives in mouse primary hepatocytes
Kojo A, Viitala P, Pasanen M, Pelkonen O, Raunio H, Juvonen R. 1998. Archives of toxicology. 72: 336-341
A convenient laboratory experiment for teaching the fundamentals of drug metabolism
Juvonen RO, Pennanen S, Pasanen M. 1997. American journal of pharmaceutical education. 61: 314-317
Interaction of Aflatoxin B1 with cytochrome P450 2A5 and its mutants: Correlation with metabolic activation and toxicity
Pelkonen P, Lang MA, Negishi M, Wild CP, Juvonen RO. 1997. Chemical research in toxicology. 10: 85-90
CYP enzymes catalyze the formation of a terminal olefin from 2-ethylhexanoic acid in rat and human liver
Pennanen S, Kojo A, Pasanen M, Liesivuori J, Juvonen RO, Komulainen H. 1996. Human and experimental toxicology. 15: 435-442
Distinct responses of mouse hepatic CYP enzymes to corn oil and peroxisome proliferators
Kojo A, Pellinen P, Juvonen R, Raunio H, Pelkonen O, Pasanen M. 1996. Biochemical pharmacology. 51: 1137-1143
Inhibition of mice coumarin 7-hydroxylase by undecanoic Ù-lactone, benzoxazole and 2H-pyran-2-one
Asikainen J, Pasanen M, Juvonen RO. Teoksessa: (toim.) , 1996. Proceedings of the 15th European Workshop on Drug Metabolism. s. 13-17. Gustav Fischer
Structural flexibility and functional versatility of cytrochrome P450 and rapid evolution
Negishi M, Iwasaki M, Juvonen RO, Sueyoshi T, Darden TA, Pedersen LG. 1996. Mutation research. 350: 43-50
A sensitive microassay reveals marked regional differences in the capacity of rat brain to generate carbon monoxide
Laitinen JT, Juvonen RO. 1995. Brain research. 694: 246-252
Comparative molecular field analysis of compounds with CYP2A5 binding affinity
Poso A, Juvonen R, Gynther J. 1995. Quantitative structure-activity relationships. 14: 507-511
Competitive inhibition of coumarin 7-hydroxylation by pilocarpine and its interaction with mouse CYP 2A5 and human CYP 2A6
Kinonen T, Pasanen M, Gynther J, Poso A, Järvinen T, Alhava E, Juvonen RO. 1995. British journal of pharmacology. 116: 2625-2630
Molecular engineering of microsomal P450 2a-4 to a stable, water-soluble enzyme
Sueyoshi T, Park LJ, Moore R, Juvonen RO, Negishi M. 1995. Archives of biochemistry and biophysics. 322: 265-271
The role of CYP enzymes in cocaine-induced liver damage
Pasanen M, Pellinen P, Stenbäck F, Juvonen RO, Raunio H, Pelkonen O. 1995. Archives of toxicology. 69: 287-290
Activation of aflatoxin B1 by mouse CYP2A enzymes and cytotoxicity in recombinant yeast cells
Pelkonen P, Lang MA, Wild CP, Negishi M, Juvonen RO. 1994. European journal of pharmacology. 292: 67-73
Clofibrate decreases CYP2A5 in male DBA/2N mice
Kojo A, Laitinen S, Pellinen P, Juvonen R, Raunio H, Pelkonen O, Pasanen M. Teoksessa: Lechner MC(toim.) , 1994. Cytochrome P450. 8th International Conference. s. 511-514. John Libbey
Coumarin and methoxsalen metabolism by CYP2A6 and CYP2a-5 isoforms in man and mouse
Mäenpää J, Juvonen R, Raunio H, Rautio A, Pelkonen O. Teoksessa: Lechner MC(toim.) , 1994. Cytochrome P450. 8th International Conference. s. 631-634. John Libbey
Function of residue-365 in mouse P4502A5 (P450coh): site directed mutagenesis, spectral and enzymatic properties
Juvonen R, Iwasaki M, Negishi M. Teoksessa: Lechner MC(toim.) , 1994. Cytochrome P450. 8th International Conference. s. 801-803. John Libbey
Metabolic interactions of methoxsalen and coumarin in humans and mice
Mäenpää J, Juvonen R, Raunio H, Rautio A, Pelkonen O. 1994. Biochemical pharmacology. 48: 1363-1369
Transgeenisillä hiivoilla testataan aflatoksiinien myrkyllisyyttä
Pelkonen P, Juvonen R. 1994. APTEEKKARI: SUOMEN APTEEKKARILEHTI. 4: 6-7

University of Eastern Finland Joensuu, Kuopio © University of Eastern Finland

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Risto Juvonen

Research groups

Alkoholien toksikokinetiikka

Alkoholimyrkytyskuolemat ja alkoholille altistuminen

Etanolimyrkytys

Etyleeniglykolimyrkytys

Evaluation of Lippia scaberrima Sond. and Aspalathus linearis (Burm.f.) R. Dahlgren extracts on human CYP enzymes and gold nanoparticle synthesis: implications for drug metabolism and cytotoxicity

Metanolimyrkytys

Identification of Gut Microbial Lysine and Histidine Degradation and CYP-Dependent Metabolites as Biomarkers of Fatty Liver Disease

Western Diet Decreases Hepatic Drug Metabolism in Male LDLr−/−ApoB100/100 Mice

A Comprehensive Evaluation of Sdox, a Promising H2S-Releasing Doxorubicin for the Treatment of Chemoresistant Tumors

In vitro metabolism of helenalin and its inhibitory effect on human cytochrome P450 activity

Toxicological Information Literacy Protects Human Health

Information literacy skills are required in finding reliable toxicological information resources

Molecular docking and oxidation kinetics of 3-phenyl coumarin derivatives by human CYP2A1

Substrate Selectivity of Coumarin Derivatives by Human CYP1 Enzymes: In Vitro Enzyme Kinetics and In Silico Modeling

Activities of metabolizing enzymes in human placenta

Coumarin-Based Profluorescent and Fluorescent Substrates for Determining Xenobiotic-Metabolizing Enzyme Activities In Vitro

In vitro sulfonation of 7-hydroxycoumarin derivatives in liver cytosol of human and six animal species

Inhibition of Human CYP1 Enzymes by a Classical Inhibitor α-Naphthoflavone and a Novel Inhibitor N-(3, 5- Dichlorophenyl)cyclopropanecarboxamide - An in Vitro and in Silico Study

Physiological and toxicological considerations

Tissue and interspecies comparison of catechol- O-methyltransferase mediated catalysis of 6- O-methylation of esculetin to scopoletin and its inhibition by entacapone and tolcapone

Alkoholien toksikokinetiikka

Alkoholimyrkytyskuolemat ja alkoholille altistuminen

Etanolimyrkytys

Etyleeniglykolimyrkytys

In Vitro Human Metabolism and Inhibition Potency of Verbascoside for CYP Enzymes

In vitro glucuronidation of 7-hydroxycoumarin derivatives in intestine and liver microsomes of Beagle dogs

Metabolism of Scoparone in Experimental Animals and Humans

Metanolimyrkytys

Blocking oestradiol synthesis pathways with potent and selective coumarin derivatives

Development of New Coumarin-Based Profluorescent Substrates for Human Cytochrome P450 Enzymes

Making it Together: Information Specialist and Toxicologist Developing Students' Professional Information Skills (Abstract)

Molecular Docking-Based Design and Development of a Highly Selective Probe Substrate for UDP-glucuronosyltransferase 1A10

New glutathione conjugate of the pyrrolizidine alkaloids produced by human cytosolic enzyme dependent reactions in vitro

Structure-Activity Relationship Analysis of 3-Phenylcoumarin-Based Monoamine Oxidase B Inhibitors

Comparison of In Vitro Hepatic Scoparone 7-O-Demethylation between Humans and Experimental Animals

Common and Distinct Interactions of Chemical Inhibitors with Cytochrome P450 CYP1A2, CYP2A6 and CYP2B6 Enzymes

Comparison of trapping profiles between d-peptides and glutathione in the identification of reactive metabolites

Discovery of urinary biomarkers of whole grain rye intake in free-living subjects using non-targeted LC-MS metabolite profiling

In Silico Prediction of the Site of Oxidation by Cytochrome P450 3A4 That Leads to the Formation of the Toxic Metabolites of Pyrrolizidine Alkaloids

Inhibitory effects and oxidation of 6-methylcoumarin, 7-methylcoumarin and 7-formylcoumarin via human CYP2A6 and its mouse and pig orthologous enzymes

Modeling of interactions between xenobiotics and cytochrome P450 (CYP) enzymes

Species-specific differences in the in vitro metabolism of lasiocarpine

Alkoholimyrkytykset ja alkoholin krooniset haitat [Luku 43]

Chloropicrin-induced toxic responses in human lung epithelial cells

Identification of a New Reactive Metabolite of Pyrrolizidine Alkaloid Retrorsine: (3H-Pyrrolizin-7-yl)methanol

Lasten lääkekasvatus

Preclinical pharmacology of FL442, a novel nonsteroidal androgen receptor modulator

Quantitative ADME Proteomics - CYP and UGT Enzymes in the Beagle Dog Liver and Intestine

Rational design of novel CYP2A6 inhibitors

Reactive Metabolites in Early Drug Development: Predictive in Vitro Tools

Vierasaineiden metabolia

A high throughput assay for the glucuronidation of 7-hydroxy-4-trifluoromethylcoumarin by recombinant human UDP-glucuronosyltransferases and liver microsomes

Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system

Yleisen toksikologian kansainvälisen maisteriohjelman kehittyminen - tieteellinen tutkimus opetuksen perustana

Aldehyde dehydrogenase inhibitors: a comprehensive review of the pharmacology, mechanism of action, substrate specificity, and clinical application

Antifungal activities of novel non-azole molecules against S. cerevisiae and C. albicans

ApoE3 mediated polymeric nanoparticles containing curcumin: Apoptosis induced in vitro anticancer activity against neuroblastoma cells

Apoptosis-induced anticancer effect of transferrinconjugated solid lipid nanoparticles of curcumin

Comparison of Electrochemical and Biological Oxidation of Pyrrolizidine Alkaloid Retrorsine

Design, synthesis, and evaluation of novel cyclic phosphates of 5-aminosalicylic acid as cytochrome P450-activated prodrugs

Function and regulation of the Cyp2a5/CYP2A6 genes in response to toxic insults in the liver

Interactions of inhibitor molecules with the human CYP2E1 enzyme active site

Metabolism of bilirubin by human cytochrome P450 2A6

2'-Deoxyguanosine as a surrogate trapping agent for DNA reactive drug metabolites

Identification of novel CYP2A6 inhibitors by virtual screening

Inhibition of human drug metabolizing cytochrome P450 enzymes by plant isoquinoline alkaloids

Simple, direct, and informative method for the assessment of CYP2C19 enzyme inactivation kinetics

d-Isomer of gly-tyr-pro-cys-pro-his-pro peptide: A novel and sensitive in vitro trapping agent to detect reactive metabolites by electrospray mass spectrometry

ApoE3 mediated poly(butyl) cyanoacrylate nanoparticles containing curcumin: study of enhanced activity of curcumin against beta amyloid induced cytotoxity using in vitro cell culture model

Mitä haittoja sienet voivat aiheuttaa? (Kuukauden kysymys)

Transferrin mediated solid lipid nanoparticles containing curcumin: Enhanced in vitro anticancer activity by induction of apoptosis

Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes

Teaching about intoxicating substances in primary school: teacher students' thoughts on the subject

Identification of inhibitors of the nicotine metabolising CYP2A6 enzyme-an in silico approach

Nicotine metabolism and urinary elimination in mouse: in vitro and in vivo

Lactobacillus rhamnosus strain GG reduces aflatoxin B1 transport, metabolism, and toxicity in Caco-2 cells

New potent and selective cytochrome P450 2B6 (CYP2B6) inhibitors based on three-dimensional quantitative structure-activity relationship (3D-QSAR) analysis