Susanna Forsberg

Chiral 1,3,4-oxadiazol-2-ones as highly selective FAAH inhibitors

Patel Jayendra Z, Parkkari Teija, Laitinen Tuomo, Kaczor Agnieszka A, Saario Susanna M, Savinainen Juha R, Navia-Paldanius Dina, Cipriano Mariateresa, Leppänen Jukka, Koshevoy Igor O, Poso Antti, Fowler Christopher J, Laitinen Jarmo T, Nevalainen Tapio. 2013. Journal of medicinal chemistry. 56: 8484-8496

The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptors

Savinainen JR, Saario SM, Laitinen JT. 2011. Acta physiologica. 2012 vol 204: 267-276

3-heterocycle-phenyl N-alkylcarbamates as FAAH inhibitors: desing, synthesis and 3D-QSAR studies

Käsnänen H, Myllymäki MJ, Minkkilä A, Kataja AO, Saario SM, Nevalainen T, Koskinen AMP & Poso A. 2010. Chemmedchem. 5: 213 - 231

Discovery and development of endocannabinoid-hydrolyzing enzyme inhibitors

Minkkilä A, Saario S & Nevalainen T. 2010. Current topics in medicinal chemistry. 10: 828 - 858

Chiral 3-(4,5-dihydrooxazol-2-yl)phenyl alkylcarbamates as novel FAAH inhibitors: Insight into FAAH enantioselectivity by molecular docking and interaction fields

Myllymäki MJ, Käsnänen H, Kataja AO, Lahtela-Kakkonen M, Saario SM, Poso A, Koskinen AMP. 2009. European journal of medicinal chemistry. 44: 4179-4191

Screening of various hormone-sensitive lipase inhibitors as endocannabinoid-hydrolyzing enzyme inhibitors

Minkkilä A, Savinainen JR, Käsnänen H, Xhaard H, Nevalainen T, Laitinen JT, Poso A, Leppänen J, Saario SM. 2009. Chemmedchem. 4: 1253-1259

The synthesis and biological evaluation of para-substituted phenolic N-alkyl carbamates as endocannabinoid hydrolyzing enzyme inhibitors

Minkkilä A, Myllymäki MJ, Saario SM, Castillo-Melendez JA, Koskinen AMP, Fowler CJ, Leppänen J, Nevalainen T. 2009. European journal of medicinal chemistry. 44: 2994-3008

Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase

Minkkilä A, Saario SM, Käsnänen H, Leppänen J, Poso A, Nevalainen T. 2008. Journal of medicinal chemistry. 51: 7057-7060

Design, synthesis, and in vitro evaluation of carbamate derivatives of 2-benzoxazolyl- and 2-benzothiazolyl-(3-hydroxyphenyl)-methanones as novel fatty acid amide hydrolase inhibitors

Myllymäki MJ, Saario SM, Kataja AO, Castillo-Melendez JA, Nevalainen T, Juvonen RO, Järvinen T, Koskinen AMP. 2007. Journal of medicinal chemistry. 50: 4236-4242

Monoglyceride lipase as an enzyme hydrolyzing 2-arachidonoylglycerol

Saario SM, Laitinen JT. 2007. Chemistry and biodiversity. 4: 1903-1913

Therapeutic potential of endocannabinoid-hydrolysing enzyme inhibitors

Saario SM, Laitinen JT. 2007. Basic and clinical pharmacology and toxicology. 101: 287-293

Alpha-methylated derivatives of 2-arachidonoyl glycerol: synthesis, CB1 receptor activity, and enzymatic stability

Parkkari T, Myllymäki M, Savinainen JR, Saario SM, Castillo-Meléndez JA, Laitinen JT, Nevalainen T, Koskinen AMP, Järvinen T. 2006. Bioorganic and medicinal chemistry letters. 16: 2437-2440

Enzymatic Hydrolysis of the Endocannabinoid 2-Arachidonoylglycerol. Characterization and Inhibition in Rat Brain Membranes and Homogenates

Saario SM. 2006. Kuopion yliopiston julkaisuja A. Farmaseuttiset tieteet

Fatty acid amide hydrolase inhibitors from virtual screening of the endocannabinoid system

Saario SM, Poso A, Juvonen RO, Järvinen T, Salo-Ahen OMH. 2006. Journal of medicinal chemistry. 49: 4650-4656

Synthesis, cannabinoid receptor activity, and enzymatic stability of reversed amide derivatives of arachidonoyl ethanolamide

Parkkari T, Savinainen JR, Raitio KH, Saario SM, Matilainen L, Sirviö T, Laitinen JT, Nevalainen T, Niemi R, Järvinen T. 2006. Bioorganic and medicinal chemistry. 14: 5252-5258

URB754 has no effect on the hydrolysis or signaling capacity of 2-AG in the rat brain

Saario SM, Palomäki V, Lehtonen M, Nevalainen T, Järvinen T, Laitinen JT. 2006. Chemistry and biology. 13: 811-814

Characterization of the sulfhydryl-sensitive site in the enzyme responsible for hydrolysis of 2-arachidonoyl-glycerol in rat cerebellar membranes

Saario SM, Salo OMH, Nevalainen T, Poso A, Laitinen JT, Järvinen T, Niemi R. 2005. Chemistry and biology. 12: 649-656

Monoglyceride lipase-like enzymatic activity is responsible for hydrolysis of 2-arachidonoylglycerol in rat cerebellar membranes

Saario SM, Savinainen JR, Laitinen JT, Järvinen T, Niemi R. 2004. Biochemical pharmacology. 67: 1381-1387

An optimized approach to study endocannabinoid signaling: evidence against constitutive activity of rat brain adenosine A1 and cannabinoid CB1 receptors

Savinainen JR, Saario SM, Niemi R, Järvinen T, Laitinen JT. 2003. British journal of pharmacology. 140: 1451-1459

4-phenylbutanoyl-2(S)-acylpyrrolidines and 4-phenylbutanoyl-L-prolyl-2(S)-acylpyrrolidines as prolyl oligopeptidase inhibitors

Wallén EAA, Christiaans JAM, Saario SM, Forsberg MM, Venäläinen JI, Paso HM, Männistö PT, Gynther J. 2002. Bioorganic and medicinal chemistry. 10: 2199-2206

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Publications

Chiral 1,3,4-oxadiazol-2-ones as highly selective FAAH inhibitors

The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptors

3-heterocycle-phenyl N-alkylcarbamates as FAAH inhibitors: desing, synthesis and 3D-QSAR studies

Discovery and development of endocannabinoid-hydrolyzing enzyme inhibitors

Chiral 3-(4,5-dihydrooxazol-2-yl)phenyl alkylcarbamates as novel FAAH inhibitors: Insight into FAAH enantioselectivity by molecular docking and interaction fields

Screening of various hormone-sensitive lipase inhibitors as endocannabinoid-hydrolyzing enzyme inhibitors

The synthesis and biological evaluation of para-substituted phenolic N-alkyl carbamates as endocannabinoid hydrolyzing enzyme inhibitors

Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase

Design, synthesis, and in vitro evaluation of carbamate derivatives of 2-benzoxazolyl- and 2-benzothiazolyl-(3-hydroxyphenyl)-methanones as novel fatty acid amide hydrolase inhibitors

Monoglyceride lipase as an enzyme hydrolyzing 2-arachidonoylglycerol

Therapeutic potential of endocannabinoid-hydrolysing enzyme inhibitors

Alpha-methylated derivatives of 2-arachidonoyl glycerol: synthesis, CB1 receptor activity, and enzymatic stability

Enzymatic Hydrolysis of the Endocannabinoid 2-Arachidonoylglycerol. Characterization and Inhibition in Rat Brain Membranes and Homogenates

Fatty acid amide hydrolase inhibitors from virtual screening of the endocannabinoid system

Synthesis, cannabinoid receptor activity, and enzymatic stability of reversed amide derivatives of arachidonoyl ethanolamide

URB754 has no effect on the hydrolysis or signaling capacity of 2-AG in the rat brain

Characterization of the sulfhydryl-sensitive site in the enzyme responsible for hydrolysis of 2-arachidonoyl-glycerol in rat cerebellar membranes

Monoglyceride lipase-like enzymatic activity is responsible for hydrolysis of 2-arachidonoylglycerol in rat cerebellar membranes

An optimized approach to study endocannabinoid signaling: evidence against constitutive activity of rat brain adenosine A1 and cannabinoid CB1 receptors

4-phenylbutanoyl-2(S)-acylpyrrolidines and 4-phenylbutanoyl-L-prolyl-2(S)-acylpyrrolidines as prolyl oligopeptidase inhibitors