Susanna Kemppainen
Project Researcher
Institute of Biomedicine, School of Medicine, Faculty of Health Sciences
[email protected] | +358 44 333 9665
I study disease mechanisms of Alzheimer’s disease from cellular signaling mechanisms to the manifestation of memory by using transgenic mouse models, primary cell cultures and organotypic hippocampal slice cultures
Publications
23/23 items-
Intracerebroventricular phospho-tau immunotherapy alleviates cortical phospho-tau burden and motor phenotype in a neuron-specific P301S tauopathy mouse
Kemppainen, S.; Aramburu-Núñez, M.; Koivisto, H.; Posado-Fernández, A.; Felix-Garcia, M.R.; Nurminen, K.; Häkli, S.; Abelli-Deulofeu, E.; Kaisto, M.; Custodia, A.; van Olst, L.; Willman, R.-M.; Mäkinen, P.; Miettinen, P.O.; Schouten, M.; Iglesias-Rey, Ramón; Kamermans, A.; Martiskainen, H.; Rauramaa, T.; de Vries, H.E.; Eng, E.; Salo, R.; Kettunen, M.; Gröhn, O.; Gureviciene, I.; Chmielevski, P.; Ouro, A.; Lapresa, R.; Agulla, J.; Almeida, A.; Doria, G.; Flores, O.; Aguiar, P.; Carmans, S.; Rouc. 2025. Experimental neurology. 391: A1 Journal article (refereed), original research -
The protective PLCγ2-P522R variant mitigates Alzheimer’s disease-associated pathologies by enhancing beneficial microglial functions
Takalo, Mari; Jeskanen, Heli; Rolova, Taisia; Kervinen, Inka; Hellén, Marianna; Heikkinen, Sami; Koivisto, Hennariikka; Jokivarsi, Kimmo; Müller, Stephan A.; Koivumäki, Esa-Mikko; Mäkinen, Petra; Juopperi, Sini-Pauliina; Willman, Roosa-Maria; Sinisalo, Rosa; Hoffmann, Dorit; Jäntti, Henna; Peitz, Michael; Fließbach, Klaus; Kuulasmaa, Teemu; Natunen, Teemu; Kemppainen, Susanna; Poutiainen, Pekka; Leinonen, Ville; Malm, Tarja; Martiskainen, Henna; Ramirez, Alfredo; Haapasalo, Annakaisa; Lichtentha. 2025. Journal of neuroinflammation. 22: . 64 A1 Journal article (refereed), original research -
Deep learning assisted quantitative analysis of Aβ and microglia in patients with idiopathic normal pressure hydrocephalus in relation to cognitive outcome
Luikku, Antti J; Nerg, Ossi; Koivisto, Anne M; Hanninen, Tuomo; Junkkari, Antti; Kemppainen, Susanna; Juopperi, Sini-Pauliina; Sinisalo, Rosa; Pesola, Alli; Soininen, Hilkka; Hiltunen, Mikko; Leinonen, Ville; Rauramaa, Tuomas; Martiskainen, Henna. 2024. Journal of neuropathology and experimental neurology. 83: 967-978 A1 Journal article (refereed), original research -
Physiological shedding and C-terminal proteolytic processing of TMEM106B
Held, Sebastian; Erck, Christian; Kemppainen, Susanna; Bleibaum, Florian; Giridhar, Neha Jadhav; Feederle, Regina; Krenner, Claudia; Juopperi, Sini-Pauliina; Calliari, Anna; Mentrup, Torben; Schröder, Bernd; Dickson, Dennis W.; Rauramaa, Tuomas; Petrucelli, Leonard; Prudencio, Mercedes; Hiltunen, Mikko; Lüningschrör, Patrick; Capell, Anja; Damme, Markus. 2024. Cell reports. 2025; 44: A1 Journal article (refereed), original research -
Organotypic Hippocampal Slice Cultures from Adult Tauopathy Mice and Theragnostic Evaluation of Nanomaterial Phospho-TAU Antibody-Conjugates
Kemppainen, Susanna; Huber, Nadine; Willman, Roosa-Maria; Zamora, Ana; Makinen, Petra; Martiskainen, Henna; Takalo, Mari; Haapasalo, Annakaisa; Sobrino, Tomas; Gomez, Manuel Antonio Gonzalez; Pineiro, Yolanda; Rivas, Jose; Himmelreich, Uwe; Hiltunen, Mikko. 2023. Cells. 12: A1 Journal article (refereed), original research -
Protective Alzheimer's disease-associated APP A673T variant predominantly decreases sAPPβ levels in cerebrospinal fluid and 2D/3D cell culture models
Wittrahm, Rebekka; Takalo, Mari; Kuulasmaa, Teemu; Mäkinen, Petra M; Mäkinen, Petri; Končarević, Saša; Fartzdinov, Vadim; Selzer, Stefan; Kokkola, Tarja; Antikainen, Leila; Martiskainen, Henna; Kemppainen, Susanna; Marttinen, Mikael; Jeskanen, Heli; Rostalski, Hannah; Rahunen, Eija; Kivipelto, Miia; Ngandu, Tiia; Natunen, Teemu; Lambert, Jean-Charles; Tanzi, Rudolph E; Kim, Doo Yeon; Rauramaa, Tuomas; Herukka, Sanna-Kaisa; Soininen, Hilkka; Laakso, Markku; Pike, Ian; Leinonen, Ville; Haapasalo, . 2023. Neurobiology of disease. 182: A1 Journal article (refereed), original research -
MECP2 Increases the Pro-Inflammatory Response of Microglial Cells and Phosphorylation at Serine 423 Regulates Neuronal Gene Expression upon Neuroinflammation
Wittrahm, Rebekka; Takalo, Mari; Marttinen, Mikael; Kuulasmaa, Teemu; Mäkinen, Petra; Kemppainen, Susanna; Martiskainen, Henna; Rauramaa, Tuomas; Pike, Ian; Leinonen, Ville; Natunen, Teemu; Haapasalo, Annakaisa; Hiltunen, Mikko. 2021. Cells. 10: 860 A1 Journal article (refereed), original research -
Diabetic phenotype in mouse and humans reduces the number of microglia around ß-amyloid plaques
Natunen, Teemu; Martiskainen, Henna; Marttinen, Mikael; Gabbouj, Sami; Koivisto, Hennariikka; Kemppainen, Susanna; Kaipainen, Satu; Takalo, Mari; Svobodová, Helena; Leppänen, Luukas; Kemiläinen, Benjam; Ryhänen, Simo; Kuulasmaa, Teemu: Rahunen, Eija: Juutinen, Sisko; Mäkinen, Petra; Miettinen, Pasi; Rauramaa, Tuomas; Pihlajamäki, Jussi; Haapasalo, Annakaisa; et al [incl. Leinonen, Ville; Tanila, Heikki; Hiltunen, Mikko]. 2020. Molecular neurodegeneration. 15: 66 A1 Journal article (refereed), original research -
Intranasal insulin activates Akt2 signaling pathway in the hippocampus of wild-type but not in APP/PS1 Alzheimer model mice
Gabbouj, S; Natunen, T; Koivisto, H; Jokivarsi, K; Takalo, M; Marttinen, M; Wittrahm, R; Kemppainen, S; Naderi, R; Posado-Fernández, A; Ryhänen, S; Mäkinen, P; Paldanius, KMA; Doria, G; Poutiainen, P; Flores, O; Haapasalo, A; Tanila, H; Hiltunen, M. 2018. Neurobiology of aging. 2019; 75: 98-108 A1 Journal article (refereed), original research -
Molecular Mechanisms of Synaptotoxicity and Neuroinflammation in Alzheimer's Disease
Marttinen, Mikael; Takalo, Mari; Natunen, Teemu; Wittrahm, Rebekka; Gabbouj, Sami; Kemppainen, Susanna; Leinonen, Ville; Tanila, Heikki; Haapasalo, Annakaisa; Hiltunen, Mikko. 2018. Frontiers in neurology. 12: 963 A2 Review article, Literature review, Systematic review