SUSANNA KEMPPAINEN
Postdoctoral Researcher
I study disease mechanisms of Alzheimer's disease from cellular signaling mechanisms to the manifestation of memory by using transgenic mouse models, primary cell cultures and organotypic hippocampal slice cultures
Contact info
Room info
Kuopio Canthia 3035
Organization
School of Medicine, Biomedicine
Keywords
Publications
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Gabbouj, S; Natunen, T; Koivisto, H; Jokivarsi, K; Takalo, M; Marttinen, M; Wittrahm, R; Kemppainen, S; Naderi, R; Posado-Fernández, A; Ryhänen, S; Mäkinen, P; Paldanius, KMA; Doria, G; Poutiainen, P; Flores, O; Haapasalo, A; Tanila, H; Hiltunen, M. 2018. Intranasal insulin activates Akt2 signaling pathway in the hippocampus of wild-type but not in APP/PS1 Alzheimer model mice NEUROBIOLOGY OF AGING 2019; 75: 98-108. 2018
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Kemppainen, Susanna. 2018. The role of neurotrophic factors in Alzheimers disease. Itä-Suomen yliopisto. Publications of the University of Eastern Finland. Dissertations in Health Sciences 452. 2018
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Marttinen, Mikael; Takalo, Mari; Natunen, Teemu; Wittrahm, Rebekka; Gabbouj, Sami; Kemppainen, Susanna; Leinonen, Ville; Tanila, Heikki; Haapasalo, Annakaisa; Hiltunen, Mikko. 2018. Molecular Mechanisms of Synaptotoxicity and Neuroinflammation in Alzheimer's Disease Frontiers in neurology 12: 963. 2018
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Guillot Florence, Kemppainen Susanna, Lavasseur Gregoire, Miettinen Pasi O, Laroche Serge, Tanila Heikki, Davis Sabrina. 2016. Brain-Specific Basal and Novelty-Induced Alternations in PI3K-Akt and MAPK/ERK Signaling in a Middle-Aged AßPP/PS1 Mouse Model of Alzheimer's Disease. Journal of Alzheimer's Disease 51 4: 1157-1173. 2016
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Kemppainen Susanna, Lindholm Päivi, Galli Emilia, Lahtinen Hanna-Maija, Koivisto Henna, Hämäläinen Elina, Saarma Mart, Taanila Heikki. 2015. Cerebral dopamine neurotrophic factor improves long-term memory in APP/PS1 transgenic mice modeling Alzheimer's disease as well as in wild-type mice. BEHAVIOURAL BRAIN RESEARCH 291: 1-11. 2015
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Natunen Teemu, Takalo Mari, Kemppainen Ssusanna, Leskelä Stina, Marttinen Mikael, Kurkinen Kaisa MA, Pursiheimo Juha-Pekka, Sarajärvi Timo, Viswanathan Jayashree, Gabbouj Sami, Solje Eino, Tahvanainen Eveliina, Pirttimäki Tiina, Kurki Mitja, Paananen Jussi, Rauramaa Tuomas, Miettinen Pasi, Mäkinen Petra, Leinonen Ville, Soininen Hilkka et al. 2015. Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models. NEUROBIOLOGY OF DISEASE (SAN DIEGO CA) 2016; 85: 187-205. 2015
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Rantala J, Kemppainen S, Ndode-Ekane XE, Lahtinen V, Bolkvadze Tamuna, Gurevicius K, Tanila H, Pitkänen A. 2015. Urokinase-type plasminogen activator deficiency has little effect on seizure susceptibility and acquired epilepsy phenotype but reduces spontaneous exploration in mice. EPILEPSY & BEHAVIOR 42: 117-128. 2015
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Kemppainen S, Hämäläinen E, Miettinen PO, Koistinaho J, Tanila H. 2014. Behavioral and neuropathological consequences of transient global ischemia in APP/PS1 Alzheimer model mice. BEHAVIOURAL BRAIN RESEARCH Volume 275, 15 December 2014: 15-26. 2014
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Takalo M, Haapasalo A, Martiskainen H, Kurkinen KM, Koivisto H, Miettinen P, Khandelwal VK, Kemppainen S, Kaminska D, Mäkinen P, Leinonen V, Pihlajamäki J, Soininen H, Laakso M, Tanila H, Hiltunen M. 2014. High-fat diet increases tau expression in the brain of T2DM and AD mice independently of peripheral metabolic status. JOURNAL OF NUTRITIONAL BIOCHEMISTRY 25 6: 634-641. 2014
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Rantamäki T, Kemppainen S, Autio H, Stavén S, Koivisto H, Kojima M, Antila H, Miettinen PO, Kärkkäinen E, Karpova N, Vesa L, Lindemann L, Hoener MC, Tanila H, Castrén E. 2013. The Impact of Bdnf Gene Deficiency to the Memory Impairment and Brain Pathology of APPswe/PS1dE9 Mouse Model of Alzheimer's Disease. PLOS ONE [ONLINE] 2013 Jul 3;8(7): e68722: -. 2013