SUSANNA KEMPPAINEN

Contact info

Keywords

RESEARCH GROUPS - UEF

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  Molecular Genetics of Alzheimer's Disease

Publications

• Wittrahm, Rebekka; Takalo, Mari; Marttinen, Mikael; Kuulasmaa, Teemu; Mäkinen, Petra; Kemppainen, Susanna; Martiskainen, Henna; Rauramaa, Tuomas; Pike, Ian; Leinonen, Ville; Natunen, Teemu; Haapasalo, Annakaisa; Hiltunen, Mikko. 2021. MECP2 Increases the Pro-Inflammatory Response of Microglial Cells and Phosphorylation at Serine 423 Regulates Neuronal Gene Expression upon Neuroinflammation Cells 10 4: 860. 2021
• Natunen, Teemu; Martiskainen, Henna; Marttinen, Mikael; Gabbouj, Sami; Koivisto, Hennariikka; Kemppainen, Susanna; Kaipainen, Satu; Takalo, Mari; Svobodová, Helena; Leppänen, Luukas; Kemiläinen, Benjam; Ryhänen, Simo; Kuulasmaa, Teemu: Rahunen, Eija: Juutinen, Sisko; Mäkinen, Petra; Miettinen, Pasi; Rauramaa, Tuomas; Pihlajamäki, Jussi; Haapasalo, Annakaisa; et al [incl. Leinonen, Ville; Tanila, H. 2020. Diabetic phenotype in mouse and humans reduces the number of microglia around ß-amyloid plaques Molecular neurodegeneration 15: 66. 2020
• Gabbouj, S; Natunen, T; Koivisto, H; Jokivarsi, K; Takalo, M; Marttinen, M; Wittrahm, R; Kemppainen, S; Naderi, R; Posado-Fernández, A; Ryhänen, S; Mäkinen, P; Paldanius, KMA; Doria, G; Poutiainen, P; Flores, O; Haapasalo, A; Tanila, H; Hiltunen, M. 2018. Intranasal insulin activates Akt2 signaling pathway in the hippocampus of wild-type but not in APP/PS1 Alzheimer model mice NEUROBIOLOGY OF AGING 2019; 75: 98-108. 2018
• Kemppainen, Susanna. 2018. The role of neurotrophic factors in Alzheimers disease. Itä-Suomen yliopisto. Publications of the University of Eastern Finland. Dissertations in Health Sciences 452. 2018
• Marttinen, Mikael; Takalo, Mari; Natunen, Teemu; Wittrahm, Rebekka; Gabbouj, Sami; Kemppainen, Susanna; Leinonen, Ville; Tanila, Heikki; Haapasalo, Annakaisa; Hiltunen, Mikko. 2018. Molecular Mechanisms of Synaptotoxicity and Neuroinflammation in Alzheimer's Disease Frontiers in neurology 12: 963. 2018
• Guillot Florence, Kemppainen Susanna, Lavasseur Gregoire, Miettinen Pasi O, Laroche Serge, Tanila Heikki, Davis Sabrina. 2016. Brain-Specific Basal and Novelty-Induced Alternations in PI3K-Akt and MAPK/ERK Signaling in a Middle-Aged AßPP/PS1 Mouse Model of Alzheimer's Disease. Journal of Alzheimer's Disease 51 4: 1157-1173. 2016
• Rantala J, Kemppainen S, Ndode-Ekane XE, Lahtinen V, Bolkvadze Tamuna, Gurevicius K, Tanila H, Pitkänen A. 2015. Urokinase-type plasminogen activator deficiency has little effect on seizure susceptibility and acquired epilepsy phenotype but reduces spontaneous exploration in mice. EPILEPSY & BEHAVIOR 42: 117-128. 2015
• Natunen Teemu, Takalo Mari, Kemppainen Ssusanna, Leskelä Stina, Marttinen Mikael, Kurkinen Kaisa MA, Pursiheimo Juha-Pekka, Sarajärvi Timo, Viswanathan Jayashree, Gabbouj Sami, Solje Eino, Tahvanainen Eveliina, Pirttimäki Tiina, Kurki Mitja, Paananen Jussi, Rauramaa Tuomas, Miettinen Pasi, Mäkinen Petra, Leinonen Ville, Soininen Hilkka et al. 2015. Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models. NEUROBIOLOGY OF DISEASE (SAN DIEGO CA) 2016; 85: 187-205. 2015
• Kemppainen Susanna, Lindholm Päivi, Galli Emilia, Lahtinen Hanna-Maija, Koivisto Henna, Hämäläinen Elina, Saarma Mart, Taanila Heikki. 2015. Cerebral dopamine neurotrophic factor improves long-term memory in APP/PS1 transgenic mice modeling Alzheimer's disease as well as in wild-type mice. BEHAVIOURAL BRAIN RESEARCH 291: 1-11. 2015
• Kemppainen S, Hämäläinen E, Miettinen PO, Koistinaho J, Tanila H. 2014. Behavioral and neuropathological consequences of transient global ischemia in APP/PS1 Alzheimer model mice. BEHAVIOURAL BRAIN RESEARCH Volume 275, 15 December 2014: 15-26. 2014
• Takalo M, Haapasalo A, Martiskainen H, Kurkinen KM, Koivisto H, Miettinen P, Khandelwal VK, Kemppainen S, Kaminska D, Mäkinen P, Leinonen V, Pihlajamäki J, Soininen H, Laakso M, Tanila H, Hiltunen M. 2014. High-fat diet increases tau expression in the brain of T2DM and AD mice independently of peripheral metabolic status. JOURNAL OF NUTRITIONAL BIOCHEMISTRY 25 6: 634-641. 2014
• Rantamäki T, Kemppainen S, Autio H, Stavén S, Koivisto H, Kojima M, Antila H, Miettinen PO, Kärkkäinen E, Karpova N, Vesa L, Lindemann L, Hoener MC, Tanila H, Castrén E. 2013. The Impact of Bdnf Gene Deficiency to the Memory Impairment and Brain Pathology of APPswe/PS1dE9 Mouse Model of Alzheimer's Disease. PLOS ONE [ONLINE] 2013 Jul 3;8(7): e68722: -. 2013
• Hiltunen M, Khandelwal VKM, Yaluri N, Tiilikainen T, Tusa M, Koivisto H, Krzisch M, Vepsäläinen S, Mäkinen P, Kemppainen S, Miettinen P, Haapasalo A, Soininen H, Laakso M, Tanila H. 2012. Contribution of genetic and dietary insulin resistance to Alzheimer phenotype in APP/PS1 transgenic mice JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 16: 1206-1222. 2012
• Kemppainen S, Rantamäki T, Jerónimo-Santos A, Lavasseur G, Autio H, Karpova N, Kärkkäinen E, Stavén S, Miranda HV, Outeiro TF, Diógenes MJ, Laroche S, Davis S, Sebastião AM, Castrén E, Tanila H.. 2012. Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice. NEUROBIOLOGY OF AGING 2012 Jun;33(6):1122.e23-39. Epub 2011 Dec 30.: e23-39. 2012
• Ihalainen Jouni, Sarajärvi Timo, Rasmusson Doug, Kemppainen Susanna, Keski-Rahkonen Pekka, Lehtonen Marko, Banerjee Pradeep K, Semba Kazue, Tanila Heikki. 2011. Effects of memantine and donepezil on cortical and hippocampal acetylcholine levels and object recognition memory in rats NEUROPHARMACOLOGY 61: 891-899. 2011
• Ihalainen J, Sarajärvi T, Kemppainen S, Keski-Rahkonen P, Lehtonen M & Tanila H. 2010. A novel delayed non-match to sample object recognition task that allows simultaneous in vivo microdialysis. JOURNAL OF NEUROSCIENCE METHODS 189: 210 - 215. 2010
• Kanninen K, Heikkinen R, Malm T, Rolova T, Kuhmonen S, Leinonen H, Ylä-Herttuala S, Tanila H, Levonen AL, Koistinaho M, Koistinaho J. 2009. Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106 38: 16505-16510. 2009