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Tapio Nevalainen

Tapio Nevalainen

University Lecturer

School of Pharmacy, Faculty of Health Sciences

tapio.nevalainen@uef.fi | +358 40 355 2479

Information Publications

Research groups

Medicinal chemistry and organic synthesis facilit… 01.01.2010 -

Publications

83/83 items

Synthesis, relative configuration and CB1 receptor affinity studies for a set of 1,2,3-triazole derivatives
Szafrański, Przemysław W; Siwek, Agata; Smaga-Maślanka, Irena; Pomierny-Chamioło, Lucyna; Ilnicki, Piotr; Żuchowski, Grzegorz; Nevalainen, Tapio; Filip, Małgorzata; Zajdel, Paweł; Cegła, Marek T. 2023. Journal of molecular structure. 1282: A1 Journal article (refereed), original research
Evaluation of FASN inhibitors by a versatile toolkit reveals differences in pharmacology between human and rodent FASN preparations and in antiproliferative efficacy in vitro vs. in situ in human cancer cells
Singha, Prosanta; Mäklin, Kiira; Vihavainen, Taina; Laitinen, Tuomo; Nevalainen, Tapio; Patil, Mahadeo; Tonduru, Arun; Poso, Antti; Laitinen, Jarmo; Savinainen, Juha. 2020. European journal of pharmaceutical sciences. 149: 105321 A1 Journal article (refereed), original research
CB2 receptor activation causes an ERK1/2-dependent inflammatory response in human RPE cells
Hytti M, Andjelic S, Josifovska N, Piippo N, Korhonen E, Hawlina M, Kaarniranta K, Nevalainen TJ, Petrovski G, Parkkari T, Kauppinen A. 2017. Scientific reports. 7: 16169 A1 Journal article (refereed), original research
Design, Synthesis, and Biological Evaluation of 2,4-Dihydropyrano[2,3-c]pyrazole Derivatives as Autotaxin Inhibitors
Pantsar T, Singha P, Nevalainen TJ, Koshevoy I, Leppänen J, Poso A, Niskanen JMA, Pasonen-Seppänen S, Savinainen JR, Laitinen T, Laitinen JT. 2017. European journal of pharmaceutical sciences. 107: 97-111 A1 Journal article (refereed), original research
Chemoproteomic, biochemical and pharmacological approaches in the discovery of inhibitors targeting human alfa/beta-hydrolase domain containing 11 (ABHD11)
Navia-Paldanius D, Patel JZ, López Navarro M, Jakupovic H, Goffart S, Pasonen-Seppänen S, Nevalainen TJ, Jääskeläinen T, Laitinen T, Laitinen JT, Savinainen JR. 2016. European journal of pharmaceutical sciences. 93: 253-263 A1 Journal article (refereed), original research
In vivo characterization of the ultrapotent monoacylglycerol lipase inhibitor {4-[bis-(benzo[d][1,3]dioxol-5-yl)methyl]-piperidin-1-yl} (1H-1,2,4-triazol-1-yl)methanone (JJKK-048)
Aaltonen Niina, Kedzierska Ewa, Orzelska-Gorka Jolanta, Lehtonen Marko, Navia-Paldanius Dina, Jakupovic Hermina, Savinainen Juha, Nevalainen Tapio, Laitinen Jarmo T, Parkkari Teija, Gynther Mikko. 2016. Journal of pharmacology and experimental therapeutics. 359: 62-72 A1 Journal article (refereed), original research
Comparative molecular field analysis and molecular dynamics studies of alpha/beta hydrolase domain containing 6 (ABHD6) inhibitors
Kaczor Agnieszka A, Targowska-Duda Katarzyna M, Patel Jayendra Z, Laitinen Tuomo, Parkkari Teija, Adams Yahaya, Nevalainen Tapio J, Poso Antti. 2015. Journal of molecular modeling. 21:250: . A1 Journal article (refereed), original research
Inhibitory effects and oxidation of 6-methylcoumarin, 7-methylcoumarin and 7-formylcoumarin via human CYP2A6 and its mouse and pig orthologous enzymes
Juvonen Risto O, Kuusisto Mira, Fohrgrup Carolin, Pitkänen Mari H, Nevalainen Tapio J, Auriola Seppo, Raunio Hannu, Pasanen Markku, Pentikäinen Olli T. 2015. Xenobiotica. 2016; 46: 14-24 A1 Journal article (refereed), original research
Loratadine analogues as MAGL inhibitors
Patel Jayendra Z, Ahenkorah Stephen, Vaara Miia, Staszewski Marek, Adams Yahaya, Laitinen Tuomo, Navia-Paldanius Dina, Parkkari Teija, Savinainen Juha R, Walczynski Krzysztof, Laitinen Jarmo T, Nevalainen Tapio J. 2015. Bioorganic and medicinal chemistry letters. 25: 1436-1442 A1 Journal article (refereed), original research
Potent and selective N-(4-sulfamoylphenyl)thiourea-based GPR55 agonists
Yrjölä Sari, Parkkari Teija, Navia-Paldanius Dina, Laitinen Tuomo, Kaczor Agnieszka A, Kokkola Tarja, Adusei-Mensah Frank, Savinainen Juha R, Laitinen Jarmo T, Poso Antti, Alexander Amy, Penman June, Stott Lisa, Anskat Marie, Irving Andrew J, Nevalainen Tapio J. 2015. European journal of medicinal chemistry. 107 (2016): 119-132 A1 Journal article (refereed), original research
Revisiting 1,3,4-Oxadiazol-2-ones: Utilization in the Development of ABHD6 Inhibitors
Patel Jayendra Z, van Bruchem John, Laitinen Tuomo, Kaczor Agnieszka A, Navia-Paldanius Dina, Parkkari Teija, Savinainen Juha R, Laitinen Jarmo T, Nevalainen Tapio J. 2015. Bioorganic and medicinal chemistry. 23: 6335-6345 A1 Journal article (refereed), original research
Biochemical and Pharmacological Characterization of the Human Lymphocyte Antigen B-Associated Transcript 5 (BAT5/ABHD16A)
Savinainen Juha R, Patel Jayendra Z, Parkkari Teija, Navia-Paldanius Dina, Marjamaa Joona JT, Laitinen Tuomo, Nevalainen Tapio, Laitinen Jarmo T. 2014. PLoS ONE. 9: e109869 A1 Journal article (refereed), original research
CB2 receptor as a potential target in age-related diseases
Kauppinen Anu, Nevalainen Tapio, Hytti Maria, Salminen Antero, Kaarniranta Kai, Parkkari Teija. 2014. Journal of biochemical and pharmacological research. 2: 33-43 A2 Review article, Literature review, Systematic review
Discovery of triterpenoids as reversible inhibitors of alpha/ß-hydrolase domain containing 12 (ABHD12)
Parkkari Teija, Haavikko Raisa, Laitinen Tuomo, Navia-Paldanius Dina, Rytilahti Roosa, Vaara Miia, Lehtonen Marko, Alakurtti Sami, Yli-Kauhaluoma Jari, Nevalainen Tapio, Savinainen Juha R, Laitinen Jarmo T. 2014. PLoS ONE. 9: e98286 A1 Journal article (refereed), original research
Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors
Patel Jayendra Z, Nevalainen Tapio J, Savinainen Juha R, Adams Yahaya, Laitinen Tuomo, Runyon Robert S, Vaara Miia, Ahenkorah Stephen, Kaczor Agnieszka A, Navia-Paldanius Dina, Gynther Mikko, Aaltonen Niina, Joharapurkar Amit A, Jain Mukul R, Haka Abigail S, Maxfield Frederick R, Laitinen Jarmo T, Parkkari Teija. 2014. Chemmedchem. 2015; 10: 253-265 A1 Journal article (refereed), original research
Piperazine and piperidine carboxamides and carbamates as inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL)
Korhonen Jani, Kuusisto Anne, van Bruchem John, Patel Jayendra Z, Laitinen Tuomo, Navia-Paldanius Dina, Laitinen Jarmo T, Savinainen Juha R, Parkkari Teija, Nevalainen Tapio J. 2014. Bioorganic and medicinal chemistry. 22: 6694-6705 A1 Journal article (refereed), original research
Robust hydrolysis of prostaglandin glycerol esters by human monoacylglycerol lipase (MAGL)
Savinainen Juha R, Kansanen Emilia, Pantsar Tatu, Navia-Paldanius Dina, Parkkari Teija, Lehtonen Marko, Laitinen Tuomo, Nevalainen Tapio, Poso Antti, Levonen Anna-Liisa, Laitinen Jarmo T. 2014. Molecular pharmacology. Epub ahead of print: - A1 Journal article (refereed), original research
Synthesis, in vitro and in vivo evaluation of 1,3,5-triazines as cannabinoid CB2 receptor agonists
Yrjölä Sari, Sarparanta Mirkka, Airaksinen Anu J, Hytti Maria, Kauppinen Anu, Pasonen-Seppänen Sanna, Adinolfi Barbara, Nieri Paola, Manera Clementina, Keinänen Outi, Poso Antti, Nevalainen Tapio J, Parkkari Teija. 2014. European journal of pharmaceutical sciences. 2015; 67: 85-96 A1 Journal article (refereed), original research
1,3,4-Oxadiazol-2-ones as fatty-acid amide hydrolase and monoacylglycerol lipase inhibitors: Synthesis, in vitro evaluation and insight into potency and selectivity determinants by molecular modelling
Käsnänen Heikki, Minkkilä Anna, Taupila Susanna, Patel Jayendra Z, Parkkari Teija, Lahtela-Kakkonen Maija, Saario Susanna M, Nevalainen Tapio, Poso Antti. 2013. European journal of pharmaceutical sciences. 49: 423-433 A1 Journal article (refereed), original research
Chiral 1,3,4-oxadiazol-2-ones as highly selective FAAH inhibitors
Patel Jayendra Z, Parkkari Teija, Laitinen Tuomo, Kaczor Agnieszka A, Saario Susanna M, Savinainen Juha R, Navia-Paldanius Dina, Cipriano Mariateresa, Leppänen Jukka, Koshevoy Igor O, Poso Antti, Fowler Christopher J, Laitinen Jarmo T, Nevalainen Tapio. 2013. Journal of medicinal chemistry. 56: 8484-8496 A1 Journal article (refereed), original research
Farmaseuttinen kemia - uudet haasteet Itä-Suomen yliopistossa
Nevalainen Tapio, Poso Antti, Rautio Jarkko. Teoksessa: Ahonen R, Laitinen K, Lapinjoki S, Mensalo P, Ranta V-P, Ylikangas H (toim).(toim.) , 2013. Muutosten vuosikymmen : Itä-Suomen yliopiston farmasian laitos 40 vuotta. s. 34-42. D2 Article in a professional book (incl. an introduction by the editor)
Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase
Aaltonen Niina, Savinainen Juha R, Ribas Casandra R, Rönkkö Jani, Kuusisto Anne, Korhonen Jani, Navia-Paldanius Dina, Häyrinen Jukka, Takabe Piia, Käsnänen Heikki, Pantsar Tatu, Laitinen Tuomo, Lehtonen Marko, Pasonen-Seppänen Sanna, Poso Antti, Nevalainen Tapio, Laitinen Jarmo T. 2013. Chemistry and biology. 20: 379-390 A1 Journal article (refereed), original research
Recent development of CB2 selective and peripheral CB1/CB2 cannabinoid receptor ligands
Nevalainen Tapio. 2013. Current medicinal chemistry. 2014:21: 187-203 A2 Review article, Literature review, Systematic review
Synthesis and biological evaluation of arylthiourea derivatives with antitubercular activity
Luo Rusong, Laitinen Tuomo, Teng Liyan, Nevalainen Tapio, Lahtela-Kakkonen Maija, Zheng Baofu, Wang Honghai, Poso Antti, Zhang Xuelian. 2013. Letters in drug design and discovery. 10: 640-650 A1 Journal article (refereed), original research
Discovery of novel cannabinoid receptor ligands by a virtual screening approach: Further development of 2,4,6-trisubstituted 1,3,5-triazines as CB2 agonists
Yrjölä Sari, Kalliokoski Tuomo, Laitinen Tuomo, Poso Antti, Parkkari Teija, Nevalainen Tapio. 2012. European journal of pharmaceutical sciences. 2013:48: 9-20 A1 Journal article (refereed), original research
Microwave-assisted synthesis of quinoline, isoquinoline, quinoxaline and quinazoline derivatives as CB2 receptor agonists
Saari Raimo, Törmä Jonna-Carita, Nevalainen Tapio. 2011. Bioorganic and medicinal chemistry. 19: 939 - 950 A1 Journal article (refereed), original research
New in vitro tools to study human constitutive androstane receptor (CAR) biology: discovery and comparison of human CAR inverse agonists
Küblbeck Jenni, Jyrkkärinne Johanna, Molnár Ferdinand, Kuningas Tiina, Patel Jayendra, Windshügel Björn, Nevalainen Tapio, Laitinen Tuomo, Sippl Wolfgang, Poso Antti, Honkakoski Paavo. 2011. Molecular pharmaceutics. 8: 2424-2433 A1 Journal article (refereed), original research
3-heterocycle-phenyl N-alkylcarbamates as FAAH inhibitors: desing, synthesis and 3D-QSAR studies
Käsnänen H, Myllymäki MJ, Minkkilä A, Kataja AO, Saario SM, Nevalainen T, Koskinen AMP & Poso A. 2010. Chemmedchem. 5: 213 - 231 A1 Journal article (refereed), original research
Antibacterial activity of N-quaternary chitosan derivates: synthesis, characterization and structure activity relationship (SAR) investigations
Rúnarsson ÖV, Holappa J, Malainer C, Steinsson H, Hjálmarsdóttir M, Nevalainen T & Másson M. 2010. European polymer journal. 46: 1251 - 1267 A1 Journal article (refereed), original research
Characterization of binding properties of monoglyceride lipase inhibitors by a versatile fluorescene-based technique
Savinainen JR, Megumi Y, Minkkilä A, Nevalainen T, & Laitinen JT. 2010. Analytical biochemistry. 399: 132-134 A1 Journal article (refereed), original research
Discovery and development of endocannabinoid-hydrolyzing enzyme inhibitors
Minkkilä A, Saario S & Nevalainen T. 2010. Current topics in medicinal chemistry. 10: 828 - 858 A2 Review article, Literature review, Systematic review
GPR55, a lysophosphatidylinositol receptor with cannabinoid sensitivity?
Nevalainen T & Irving AJ. 2010. Current topics in medicinal chemistry. 10: 799 - 813 A2 Review article, Literature review, Systematic review
The medicinal chemistry of endocannabinoid system 25 Jan [Editorial]
Nevalainen Tapio, Minkkilä Anna. 2010. Current topics in medicinal chemistry. 10: 767 B1 Non-refereed journal articles
Screening of various hormone-sensitive lipase inhibitors as endocannabinoid-hydrolyzing enzyme inhibitors
Minkkilä A, Savinainen JR, Käsnänen H, Xhaard H, Nevalainen T, Laitinen JT, Poso A, Leppänen J, Saario SM. 2009. Chemmedchem. 4: 1253-1259 A1 Journal article (refereed), original research
Synthesis of quinolinyl and isoquinolinyl phenyl ketones as novel agonists for the cannabinoid CB2 receptor
Reux B, Nevalainen T, Raitio KH, Koskinen AMP. 2009. Bioorganic and medicinal chemistry. 17: 4441-4447 A1 Journal article (refereed), original research
The synthesis and biological evaluation of para-substituted phenolic N-alkyl carbamates as endocannabinoid hydrolyzing enzyme inhibitors
Minkkilä A, Myllymäki MJ, Saario SM, Castillo-Melendez JA, Koskinen AMP, Fowler CJ, Leppänen J, Nevalainen T. 2009. European journal of medicinal chemistry. 44: 2994-3008 A1 Journal article (refereed), original research
Antimicrobial activity of piperazine derivatives of chitosan
Másson M, Holappa J, Hjálmarsdóttir M, Rúnarsson ÖV, Nevalainen T, Järvinen T. 2008. Carbohydrate polymers. 74: 566-571 A1 Journal article (refereed), original research
Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase
Minkkilä A, Saario SM, Käsnänen H, Leppänen J, Poso A, Nevalainen T. 2008. Journal of medicinal chemistry. 51: 7057-7060 A1 Journal article (refereed), original research
Large neutral amino acid transporter enables brain drug delivery via prodrugs
Gynther M, Laine K, Ropponen J, Leppänen J, Mannila A, Nevalainen T, Savolainen J, Järvinen T, Rautio J. 2008. Journal of medicinal chemistry. 51: 932-936 A1 Journal article (refereed), original research
Synthesis, in vitro and in vivo characterization of novel ethyl dioxy phosphate prodrug of propofol
Kumpulainen H, Järvinen T, Mannila A, Leppänen J, Nevalainen T, Mäntylä A, Vepsäläinen J, Rautio J. 2008. European journal of pharmaceutical sciences. 34: 110-117 A1 Journal article (refereed), original research
Antibacterial activity of methylated chitosan and chitooligomer derivatives: synthesis and structure activity relationships
Rúnarsson ÖV, Holappa J, Nevalainen T, Hjálmarsdottir M, Järvinen T, Loftsson T, Einarsson JM, Jónsdóttir S, Valdimarsdóttir M, Másson M. 2007. European polymer journal. 43: 2660-2671 A1 Journal article (refereed), original research
Design, synthesis, and in vitro evaluation of carbamate derivatives of 2-benzoxazolyl- and 2-benzothiazolyl-(3-hydroxyphenyl)-methanones as novel fatty acid amide hydrolase inhibitors
Myllymäki MJ, Saario SM, Kataja AO, Castillo-Melendez JA, Nevalainen T, Juvonen RO, Järvinen T, Koskinen AMP. 2007. Journal of medicinal chemistry. 50: 4236-4242 A1 Journal article (refereed), original research
Novel N- Heterocyclic phenyl carbamates as novel FAAH-inhibitors
Mikko Myllymäki, Joel A Castillo-Melendez, Ari Koskinen, Anna Minkkilä, Susanna Saario, Tapio Nevalainen, Tomi Järvinen, Antti Poso, Outi Salo-Ahen. 2007. H1 Granted patent
3D-QSAR studies on cannabinoid CB1 receptor agonists: G-protein activation as biological data
Salo OMH, Savinainen JR, Parkkari T, Nevalainen T, Lahtela-Kakkonen M, Gynther J, Laitinen JT, Järvinen T, Poso A. 2006. Journal of medicinal chemistry. 49: 554-566 A1 Journal article (refereed), original research
A novel and selective synthesis of di- and trimethylpiperazinium acetic acid iodide salts
Holappa J, Nevalainen T, Safin R, Vepsäläinen J, Järvinen T. 2006. Tetrahedron letters. 47: 323-325 A1 Journal article (refereed), original research
Alpha-methylated derivatives of 2-arachidonoyl glycerol: synthesis, CB1 receptor activity, and enzymatic stability
Parkkari T, Myllymäki M, Savinainen JR, Saario SM, Castillo-Meléndez JA, Laitinen JT, Nevalainen T, Koskinen AMP, Järvinen T. 2006. Bioorganic and medicinal chemistry letters. 16: 2437-2440 A1 Journal article (refereed), original research
Antimicrobial activity of chitosan N-betainates
Holappa J, Hjálmarsdóttir M, Másson M, Rúnarsson Ö, Asplund T, Soininen P, Nevalainen T, Järvinen T. 2006. Carbohydrate polymers. 65: 114-118 A1 Journal article (refereed), original research
Novel Quaternary Polymers
Jukka Holappa, Tomi Järvinen, Tapio Nevalainen, Jouko Savolainen, Rustam Safin. 2006. H1 Granted patent
Novel water-soluble quaternary piperazine derivatives of chitosan: synthesis and characterization
Holappa J, Nevalainen T, Safin R, Soininen P, Asplund T, Luttikhedde T, Másson M, Järvinen T. 2006. Macromolecular bioscience. 6: 139-144 A1 Journal article (refereed), original research
Synthesis and CB1receptor activities of dimethylheptyl derivatives of 2-arachidonoyl glycerol (2-AG) and 2-arachidonyl glyceryl ether (2-AGE)
Parkkari T, Salo OMH, Huttunen KM, Savinainen JR, Laitinen JT, Poso A, Nevalainen T, Järvinen T. 2006. Bioorganic and medicinal chemistry. 14: 2850-2858 A1 Journal article (refereed), original research
Synthesis and SAR studies of 2-oxoquinoline derivatives as CB2 receptor inverse agonists
Raitio KH, Savinainen JR, Vepsäläinen J, Laitinen JT, Poso A, Järvinen T, Nevalainen T. 2006. Journal of medicinal chemistry. 49: 2022-2027 A1 Journal article (refereed), original research
Synthesis and characterization of novel water-soluble quaternary piperazine derivatives of chitosan
Holoppa J, Nevalainen T, Safin R, Soininen P, Asplund T, Luttikhedde T, Másson M, Järvinen T. 2006. Macromolecular bioscience. 6: 139-144 A1 Journal article (refereed), original research
Synthesis and in vitro evaluation of novel 2-oxo-1,2-dihydroquinoline CB2 receptor inverse agonists
Raitio KH, Savinainen JR, Nevalainen T, Järvinen T, Vepsäläinen J. 2006. Chemical biology and drug design. 68: 334-340 A1 Journal article (refereed), original research
Synthesis of novel quaternary chitosan derivatives via N-Chloroacyl-6-O-triphenylmethylchitosans
Holappa J, Nevalainen T, Soininen P, Másson M, Järvinen T. 2006. Biomacromolecules. 7: 407-410 A1 Journal article (refereed), original research
Synthesis, cannabinoid receptor activity, and enzymatic stability of reversed amide derivatives of arachidonoyl ethanolamide
Parkkari T, Savinainen JR, Raitio KH, Saario SM, Matilainen L, Sirviö T, Laitinen JT, Nevalainen T, Niemi R, Järvinen T. 2006. Bioorganic and medicinal chemistry. 14: 5252-5258 A1 Journal article (refereed), original research
URB754 has no effect on the hydrolysis or signaling capacity of 2-AG in the rat brain
Saario SM, Palomäki V, Lehtonen M, Nevalainen T, Järvinen T, Laitinen JT. 2006. Chemistry and biology. 13: 811-814 A1 Journal article (refereed), original research
Characterization of the sulfhydryl-sensitive site in the enzyme responsible for hydrolysis of 2-arachidonoyl-glycerol in rat cerebellar membranes
Saario SM, Salo OMH, Nevalainen T, Poso A, Laitinen JT, Järvinen T, Niemi R. 2005. Chemistry and biology. 12: 649-656 A1 Journal article (refereed), original research
N-chloroacyl-6-O-triphenylmethylchitosans: Useful intermediates for synthetic modifications of chitosan
Holappa J, Nevalainen T, Soininen P, Elomaa M, Safin R, Másson M, Järvinen T. 2005. Biomacromolecules. 6: 858-863 A1 Journal article (refereed), original research
Targeting the cannabinoid CB2 receptor: Mutations, modeling and development of CB2 selective ligands
Raitio KH, Salo OMH, Nevalainen T, Poso A, Järvinen T. 2005. Current medicinal chemistry. 12: 1217-1237 A1 Journal article (refereed), original research
Virtual screening of novel CB2 ligands using a comparative model of the human cannabinoid CB2 receptor
Salo OMH, Raitio KH, Savinainen JR, Nevalainen T, Lahtela-Kakkonen M, Laitinen JT, Järvinen T, Poso A. 2005. Journal of medicinal chemistry. 48: 7166-7171 A1 Journal article (refereed), original research
A methylester of the glucuronide prodrug DOX-GA3 for improvement of tumor-selective chemotherapy
de Graaf M, Nevalainen TJ, Scheeren HW, Pinedo HM, Haisma HJ, Boven E. 2004. Biochemical pharmacology. 68: 2273-2281 A1 Journal article (refereed), original research
Design, synthesis and in vitro evaluation of novel water-soluble prodrugs of buparvaquone
Mäntylä A, Rautio J, Nevalainen T, Keski-Rahkonen P, Vepsäläinen J, Järvinen T. 2004. European journal of pharmaceutical sciences. : 151-158 A1 Journal article (refereed), original research
Synthesis and CB1 receptor activities of novel arachidonyl alcohol derivatives
Parkkari T, Savinainen JR, Rauhala AL, Tolonen TL, Nevalainen T, Laitinen JT, Gynther J, Järvinen T. 2004. Bioorganic and medicinal chemistry letters. 14: 3231-3234 A1 Journal article (refereed), original research
Synthesis and antileishmanial activity of novel buparvaquone oxime derivatives
Mäntylä A, Rautio J, Nevalainen T, Vepsälainen J, Juvonen R, Kendrick H, Garnier T, Croft SL, Järvinen T. 2004. Bioorganic and medicinal chemistry. 12: 3497-3502 A1 Journal article (refereed), original research
Synthesis and characterization of chitosan N-betainates having various degrees of substitution
Holappa J, Nevalainen T, Savolainen J, Soininen P, Elomaa M, Safin R, Suvanto S, Pakkanen T, Másson M, Loftsson T, Järvinen T. 2004. Macromolecules. 37: 2784-2789 A1 Journal article (refereed), original research
Synthesis and characterization of chitosan N-betainates with various degrees of substitution
Holappa J, Nevalainen T, Savolainen J, Soininen P, Safin R, Elomaa M, Järvinen T. Teoksessa: Boucher I, Jamieson K, Retnakaran A(toim.) , 2004. Advances in Chitin Science Volume VII. Proceedings of the 9th International Chitin Chitosan Conference. s. 170-172. A4 Conference proceedings
Synthesis, in vitro evaluation, and antileishmanial activity of water-soluble prodrugs of buparvaquone
Mäntylä A, Garnier T, Rautio J, Nevalainen T, Vepsäläinen J, Koskinen A, Croft SL, Järvinen T. 2004. Journal of medicinal chemistry. 47: 188-195 A1 Journal article (refereed), original research
Anandamide prodrugs: 1. Water-soluble phosphate esters of arachidonylethanolamide and R-methanandamide
Juntunen J, Huuskonen J, Laine K, Niemi R, Taipale H, Nevalainen T, Pate DW, Järvinen T. 2003. European journal of pharmaceutical sciences. 19: 37-43 A1 Journal article (refereed), original research
Ei-steroidaalisten anti-inflammatoristen karboksyylihappojen aihiolääkkeitä sisältävät farmaseuttiset koostumukset topikaaliseen käyttöön
Järvinen T, Rautio J, Nevalainen T, Taipale H, Vepsäläinen J, Gynther J. 2003. H1 Granted patent
A novel synthetic route for the preparation of alkyl and benzyl chloromethyl phosphates
Mäntylä A, Vepsäläinen J, Järvinen T, Nevalainen T. 2002. Tetrahedron letters. 43: 3793-3794 A1 Journal article (refereed), original research
Cycloserine fatty acid derivatives as prodrugs: synthesis, degradation and in vitro skin permeability
Thorsteinsson T, Másson M, Jarvinen T, Nevalainen T, Loftsson T. 2002. Chemical and pharmaceutical bulletin. 50: 554-557 A1 Journal article (refereed), original research
Design and synthesis of a novel L-dopa-entacapone codrug
Leppänen J, Huuskonen J, Nevalainen T, Gynther J, Taipale H, Järvinen T. 2002. Journal of medicinal chemistry. 45: 1379-1382 A1 Journal article (refereed), original research
Structural studies of acyl esters of entacapone
Leppänen J, Wegelius E, Nevalainen T, Järvinen T, Gynther J, Huuskonen J. 2001. Journal of molecular structure. 562: 129-135 A1 Journal article (refereed), original research
Synthesis and in-vitro/in-vivo evaluation of orally administered entacapone prodrugs
Leppänen J, Savolainen J, Nevalainen T, Forsberg M, Huuskonen J, Taipale H, Gynther J, Männistö PT, Järvinen T. 2001. Journal of pharmacy and pharmacology. 53: 1489-1498 A1 Journal article (refereed), original research
Synthesis of novel paclitaxel prodrugs designed for bioreductive activation in hypoxic tumour tissue
Damen EWP, Nevalainen TJ, van den Bergh TJM, de Groot FMH, Scheeren HW. 2001. Bioorganic and medicinal chemistry. 10: 71-77 A1 Journal article (refereed), original research
Piperazinylalkyl prodrugs of naproxen improve in vitro skin permeation
Rautio J, Nevalainen T, Taipale H, Vepsäläinen J, Gynther J, Laine K, Järvinen T. 2000. European journal of pharmaceutical sciences. 11: 157-163 A1 Journal article (refereed), original research
Synthesis and in vitro evaluation of novel morpholinyl- and methylpiperazinylacyloxyalkyl prodrugs of 2-(6-methoxy-2-naphthyl)propionic acid (naproxen) for topical drug delivery
Rautio J, Nevalainen T, Taipale H, Vepsäläinen J, Gynther J, Laine K, Järvinen T. 2000. Journal of medicinal chemistry. 43: 1489-1494 A1 Journal article (refereed), original research
Synthesis and in vitro/in vivo evaluation of novel oral N-alkyl- and N,N-dialkyl-carbamate esters of entacapone
Savolainen J, Leppanen J, Forsberg M, Taipale H, Nevalainen T, Huuskonen J, Gynther J, Mannisto PT, Jarvinen T. 2000. Life sciences. 67: 205-216 A1 Journal article (refereed), original research
Synthesis of a water-soluble prodrug of entacapone
Leppänen J, Huuskonen J, Savolainen J, Nevalainen T, Taipale H, Vepsäläinen J, Gynther J, Järvinen T. 2000. Bioorganic and medicinal chemistry letters. 10: 1967-1969 A1 Journal article (refereed), original research
Synthesis and in vitro evaluation of aminoacyloxyalkyl esters of 2-(6-methoxy-2-naphthyl) propionic acid as novel naproxen prodrugs for dermal drug delivery
Rautio J, Nevalainen T, Taipale H, Vepsäläinen J, Gynther J, Pedersen T, Järvinen T. 1999. Pharmaceutical research. 16: 1172-1178 A1 Journal article (refereed), original research
In vitro evaluation of acyloxyalkyl esters as dermal prodrugs of ketoprofen and naproxen
Rautio J, Taipale H, Gynther J, Vepsäläinen J, Nevalainen T, Järvinen T. 1998. Journal of pharmaceutical sciences. 87: 1622-1628 A1 Journal article (refereed), original research
Ethoxyresorufin-O-deethylase induction potency of polychlorinated diphenyl ethers in H411E rat hepatoma cells
Koistinen J, Sanderson JT, Giesy JP, Nevalainen T, Paasivirta J. 1996. Environmental toxicology and chemistry. 15: 2028-2034 A1 Journal article (refereed), original research
NMR spectra of some chlorinated diphenyliodonium salts and iodobenzenes
Nevalainen T, Kolehmainen E. 1996. Magnetic resonance in chemistry. 34: 965-971 A1 Journal article (refereed), original research

University of Eastern Finland Joensuu, Kuopio © University of Eastern Finland

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Tapio Nevalainen

Research groups

Synthesis, relative configuration and CB1 receptor affinity studies for a set of 1,2,3-triazole derivatives

Evaluation of FASN inhibitors by a versatile toolkit reveals differences in pharmacology between human and rodent FASN preparations and in antiproliferative efficacy in vitro vs. in situ in human cancer cells

CB2 receptor activation causes an ERK1/2-dependent inflammatory response in human RPE cells

Design, Synthesis, and Biological Evaluation of 2,4-Dihydropyrano[2,3-c]pyrazole Derivatives as Autotaxin Inhibitors

Chemoproteomic, biochemical and pharmacological approaches in the discovery of inhibitors targeting human alfa/beta-hydrolase domain containing 11 (ABHD11)

In vivo characterization of the ultrapotent monoacylglycerol lipase inhibitor {4-[bis-(benzo[d][1,3]dioxol-5-yl)methyl]-piperidin-1-yl} (1H-1,2,4-triazol-1-yl)methanone (JJKK-048)

Comparative molecular field analysis and molecular dynamics studies of alpha/beta hydrolase domain containing 6 (ABHD6) inhibitors

Inhibitory effects and oxidation of 6-methylcoumarin, 7-methylcoumarin and 7-formylcoumarin via human CYP2A6 and its mouse and pig orthologous enzymes

Loratadine analogues as MAGL inhibitors

Potent and selective N-(4-sulfamoylphenyl)thiourea-based GPR55 agonists

Revisiting 1,3,4-Oxadiazol-2-ones: Utilization in the Development of ABHD6 Inhibitors

Biochemical and Pharmacological Characterization of the Human Lymphocyte Antigen B-Associated Transcript 5 (BAT5/ABHD16A)

CB2 receptor as a potential target in age-related diseases

Discovery of triterpenoids as reversible inhibitors of alpha/ß-hydrolase domain containing 12 (ABHD12)

Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors

Piperazine and piperidine carboxamides and carbamates as inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL)

Robust hydrolysis of prostaglandin glycerol esters by human monoacylglycerol lipase (MAGL)

Synthesis, in vitro and in vivo evaluation of 1,3,5-triazines as cannabinoid CB2 receptor agonists

1,3,4-Oxadiazol-2-ones as fatty-acid amide hydrolase and monoacylglycerol lipase inhibitors: Synthesis, in vitro evaluation and insight into potency and selectivity determinants by molecular modelling

Chiral 1,3,4-oxadiazol-2-ones as highly selective FAAH inhibitors

Farmaseuttinen kemia - uudet haasteet Itä-Suomen yliopistossa

Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase

Recent development of CB2 selective and peripheral CB1/CB2 cannabinoid receptor ligands

Synthesis and biological evaluation of arylthiourea derivatives with antitubercular activity

Discovery of novel cannabinoid receptor ligands by a virtual screening approach: Further development of 2,4,6-trisubstituted 1,3,5-triazines as CB2 agonists

Microwave-assisted synthesis of quinoline, isoquinoline, quinoxaline and quinazoline derivatives as CB2 receptor agonists

New in vitro tools to study human constitutive androstane receptor (CAR) biology: discovery and comparison of human CAR inverse agonists

3-heterocycle-phenyl N-alkylcarbamates as FAAH inhibitors: desing, synthesis and 3D-QSAR studies

Antibacterial activity of N-quaternary chitosan derivates: synthesis, characterization and structure activity relationship (SAR) investigations

Characterization of binding properties of monoglyceride lipase inhibitors by a versatile fluorescene-based technique

Discovery and development of endocannabinoid-hydrolyzing enzyme inhibitors

GPR55, a lysophosphatidylinositol receptor with cannabinoid sensitivity?

The medicinal chemistry of endocannabinoid system 25 Jan [Editorial]

Screening of various hormone-sensitive lipase inhibitors as endocannabinoid-hydrolyzing enzyme inhibitors

Synthesis of quinolinyl and isoquinolinyl phenyl ketones as novel agonists for the cannabinoid CB2 receptor

The synthesis and biological evaluation of para-substituted phenolic N-alkyl carbamates as endocannabinoid hydrolyzing enzyme inhibitors

Antimicrobial activity of piperazine derivatives of chitosan

Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase

Large neutral amino acid transporter enables brain drug delivery via prodrugs

Synthesis, in vitro and in vivo characterization of novel ethyl dioxy phosphate prodrug of propofol

Antibacterial activity of methylated chitosan and chitooligomer derivatives: synthesis and structure activity relationships

Design, synthesis, and in vitro evaluation of carbamate derivatives of 2-benzoxazolyl- and 2-benzothiazolyl-(3-hydroxyphenyl)-methanones as novel fatty acid amide hydrolase inhibitors

Novel N- Heterocyclic phenyl carbamates as novel FAAH-inhibitors

3D-QSAR studies on cannabinoid CB1 receptor agonists: G-protein activation as biological data

A novel and selective synthesis of di- and trimethylpiperazinium acetic acid iodide salts

Alpha-methylated derivatives of 2-arachidonoyl glycerol: synthesis, CB1 receptor activity, and enzymatic stability

Antimicrobial activity of chitosan N-betainates

Novel Quaternary Polymers

Novel water-soluble quaternary piperazine derivatives of chitosan: synthesis and characterization

Synthesis and CB1receptor activities of dimethylheptyl derivatives of 2-arachidonoyl glycerol (2-AG) and 2-arachidonyl glyceryl ether (2-AGE)

Synthesis and SAR studies of 2-oxoquinoline derivatives as CB2 receptor inverse agonists

Synthesis and characterization of novel water-soluble quaternary piperazine derivatives of chitosan

Synthesis and in vitro evaluation of novel 2-oxo-1,2-dihydroquinoline CB2 receptor inverse agonists

Synthesis of novel quaternary chitosan derivatives via N-Chloroacyl-6-O-triphenylmethylchitosans

Synthesis, cannabinoid receptor activity, and enzymatic stability of reversed amide derivatives of arachidonoyl ethanolamide

URB754 has no effect on the hydrolysis or signaling capacity of 2-AG in the rat brain

Characterization of the sulfhydryl-sensitive site in the enzyme responsible for hydrolysis of 2-arachidonoyl-glycerol in rat cerebellar membranes

N-chloroacyl-6-O-triphenylmethylchitosans: Useful intermediates for synthetic modifications of chitosan

Targeting the cannabinoid CB2 receptor: Mutations, modeling and development of CB2 selective ligands

Virtual screening of novel CB2 ligands using a comparative model of the human cannabinoid CB2 receptor

A methylester of the glucuronide prodrug DOX-GA3 for improvement of tumor-selective chemotherapy

Design, synthesis and in vitro evaluation of novel water-soluble prodrugs of buparvaquone

Synthesis and CB1 receptor activities of novel arachidonyl alcohol derivatives

Synthesis and antileishmanial activity of novel buparvaquone oxime derivatives

Synthesis and characterization of chitosan N-betainates having various degrees of substitution

Synthesis and characterization of chitosan N-betainates with various degrees of substitution

Synthesis, in vitro evaluation, and antileishmanial activity of water-soluble prodrugs of buparvaquone

Anandamide prodrugs: 1. Water-soluble phosphate esters of arachidonylethanolamide and R-methanandamide

Ei-steroidaalisten anti-inflammatoristen karboksyylihappojen aihiolääkkeitä sisältävät farmaseuttiset koostumukset topikaaliseen käyttöön

A novel synthetic route for the preparation of alkyl and benzyl chloromethyl phosphates

Cycloserine fatty acid derivatives as prodrugs: synthesis, degradation and in vitro skin permeability

Design and synthesis of a novel L-dopa-entacapone codrug

Structural studies of acyl esters of entacapone

Synthesis and in-vitro/in-vivo evaluation of orally administered entacapone prodrugs

Synthesis of novel paclitaxel prodrugs designed for bioreductive activation in hypoxic tumour tissue

Piperazinylalkyl prodrugs of naproxen improve in vitro skin permeation

Synthesis and in vitro evaluation of novel morpholinyl- and methylpiperazinylacyloxyalkyl prodrugs of 2-(6-methoxy-2-naphthyl)propionic acid (naproxen) for topical drug delivery