Tiia Turunen
Grant-funded Researcher
A.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences
tiia.a.turunen@uef.fi
My research focuses on non-coding RNAs (ncRNAs) and how they regulate gene expression, especially during hypoxia. I’m specifically interested in small ncRNAs, such as microRNAs (miRNAs), and their action in cell nuclei. miRNAs downregulate gene expression by targeting messenger-RNAs in the cytoplasm, but they also have roles in e.g. alternative splicing and transcriptional gene regulation in the nucleus that are still less studied. Importantly, miRNAs targeting the promoter regions of genes can induce target gene expression. We can utilize this feature in new RNA therapy (Epigenetherapy). I’m also studying extracellular vesicles (EVs), such as exosomes. My research aims to develop engineered EV carrier by modifying EVs for enhanced RNA loading into EVs and targeting them to hypoxic tissue.
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1 itemsPublications
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Alzheimer's disease-induced phagocytic microglia express a specific profile of coding and non-coding RNAs
Scoyni, Flavia; Giudice, Luca; Väänänen, Mari Anna; Downes, Nicholas; Korhonen, Paula; Choo, Xin Yi; Välimäki, Nelli Noora; Mäkinen, Petri; Korvenlaita, Nea; Rozemuller, Annemieke J; de Vries, Helga E; Polo, Jose; Turunen, Tiia A; Ylä-Herttuala, Seppo; Hansen, Thomas B; Grubman, Alexandra; Kaikkonen, Minna U; Malm, Tarja. 2023. Alzheimer's & dementia. 2024; 20: 954-974 -
Construction of Fusion Protein for Enhanced Small RNA Loading to Extracellular Vesicles
Es-Haghi, Masoumeh; Neustroeva, Olga; Chowdhury, Iftekhar; Laitinen, Pia; Väänänen, Mari-Anna; Korvenlaita, Nea; Malm, Tarja; Turunen, Mikko P; Turunen, Tiia A. 2023. Genes. 14: -
Hypoxic regulation of hypoxia inducible factor 1 alpha via antisense transcription
Downes, Nicholas; Niskanen, Henri; Tomas-Bosch, Vanesa; Taipale, Mari; Godiwala, Mehvash; Väänänen, Mari-Anna; Turunen, Tiia A; Aavik, Einari; Laham-Karam, Nihay; Ylä-Herttuala, Seppo; Kaikkonen, Minna U. 2023. Journal of biological chemistry. 299: -
Nuclear microRNA-466c regulates Vegfa expression in response to hypoxia
Laitinen, Pia; Väänänen, Mari-Anna; Kolari, Ida-Liisa; Mäkinen, Petri I.; Kaikkonen, Minna U.; Weinberg, Marc S.; Morris, Kevin V.; Korhonen, Paula; Malm, Tarja; Ylä-Herttuala, Seppo; Roberts, Thomas C.; Turunen, Mikko P.; Turunen, Tiia A.. 2022. PLoS ONE. 17: -
Small Activating RNA Therapy for Angiogenesis
Laitinen, Pia; Turunen, Tiia A; Turunen, Mikko P. Teoksessa: Yun, YH; Yoder, KE(toim.) , 2022. Biotechnologies for Gene Therapy: RNA, CRISPR, Nanobots, and Preclinical Applications. s. 45-59. Springer -
Extracellular vesicles provide a capsid-free vector for oncolytic adenoviral DNA delivery
Saari, H; Turunen, T; Lõhmus, A; Turunen, M; Jalasvuori, M; Butcher, SJ; Ylä-Herttuala, S; Viitala, T; Cerullo, V; Siljander, PRM; Yliperttula, M. 2020. Journal of extracellular vesicles. 9: 1747206 -
Intracerebral overexpression of miR-669c is protective in mouse ischemic stroke model by targeting MyD88 and inducing alternative microglial/macrophage activation
Kolosowska, Natalia; Gotkiewicz, Maria; Dhungana, Hiramani; Giudice, Luca; Giugno, Rosalba; Box, Daphne; Huuskonen, Mikko T.; Korhonen, Paula; Scoyni, Flavia; Kanninen, Katja M.; Ylä-Herttuala, Seppo; Turunen, Tiia A.; Turunen, Mikko P.; Koistinaho, Jari; Malm, Tarja. 2020. Journal of neuroinflammation. 17: 194 -
Peripheral inflammation preceeding ischemia impairs neuronal survival through mechanisms involving miR-127 in aged animals
Loppi, Sanna; Korhonen, Paula; Bouvy-Liivrand, Maria; Cagliola, Simone; Turunen, Tiia A; Turunen, Mikko P; Hernandez de Sande, Ana; Kolosowska, Natalia; Scoyni, Flavia; Rosell, Anna; García-Berrocoso, Teresa; Lemarchant, Sighild; Dhungana, Hiramani; Montaner, Joan; Koistinaho, Jari; Kanninen, Katja M; Kaikkonen, Minna U; Giugno, Rosalba; Heinäniemi, Merja; Malm, Tarja. 2020. Aging cell. 2021; 20: e13287 -
Changes in nuclear and cytoplasmic microRNA distribution in response to hypoxic stress
Turunen, TA; Roberts, TC; Laitinen, P; Väänänen, MA; Korhonen, P; Malm, T; Ylä-Herttuala, S; Turunen, M. 2019. Scientific reports. 9: 10332 -
Activating the Chromatin by Noncoding RNAs
Laham-Karam, Nihay; Laitinen, Pia; Turunen, Tiia A; Ylä-Herttuala, Seppo. 2017. Antioxidants and redox signaling. 2018; 29: 813-831