Tiina Jääskeläinen

Lack of androgen receptor SUMOylation results in male infertility due to epididymal dysfunction

Zhang, Fu-Ping; Malinen, Marjo; Mehmood, Arfa; Lehtiniemi, Tiina; Jääskeläinen, Tiina; Niskanen, Einari A; Korhonen, Hanna; Laiho, Asta; Elo, Laura L; Ohlsson, Claes; Kotaja, Noora; Poutanen, Matti; Sipilä, Petra; Palvimo, Jorma J. 2019. Nature communications. 10: 777

ZNHIT3 is defective in PEHO syndrome, a severe encephalopathy with cerebellar granule neuron loss

Anttonen Anna-Kaisa, Laari Anni, Kousi Maria, Yang Yawei J, Jääskeläinen Tiina, Somer Mirja, Siintola Eija, Jakkula Eveliina, Muona Mikko, Tegelberg Saara, Lönnqvist Tuula, Pihko Helena, Valanne Leena, Paetau Anders, Lun Melody P, Hästbacka Johanna, Kopra Outi, Joensuu Tarja, Katsanis Nicholas, Lehtinen Maria K, Palvimo Jorma J, Lehesjoki Anna-Elina. 2017. Brain. 140: 1267-1279

Chemoproteomic, biochemical and pharmacological approaches in the discovery of inhibitors targeting human alfa/beta-hydrolase domain containing 11 (ABHD11)

Navia-Paldanius D, Patel JZ, López Navarro M, Jakupovic H, Goffart S, Pasonen-Seppänen S, Nevalainen TJ, Jääskeläinen T, Laitinen T, Laitinen JT, Savinainen JR. 2016. European journal of pharmaceutical sciences. 93: 253-263

Complete androgen insensitivity syndrome caused by a deep intronic pseudoexon-activating mutation in the androgen receptor gene

Känsäkoski Johanna, Jääskeläinen Jarmo, Jääskeläinen Tiina, Tommiska Johanna, Saarinen Lilli, Lehtonen Rainer, Hautaniemi Sampsa, Frilander Mikko J, Palvimo Jorma J, Toppari Jorma, Raivio Taneli. 2016. Scientific reports. 6: 32819

Androgen receptor- and PIAS1-regulated gene programs in molecular apocrine breast cancer cells

Malinen Marjo, Toropainen Sari, Jääskeläinen Tiina, Sahu Biswajyoti, Jänne Olli A, Palvimo Jorma J. 2015. Molecular and cellular endocrinology. 414: 91-98

Synthesis and Biological Evaluation of Second-Generation Tropanol-Based Androgen Receptor Modulators

Sundén Henrik, Holland Mareike C, Poutiainen Pekka K, Jääskeläinen Tiina, Pulkkinen Juha T, Palvimo Jorma J, Olsson Roger. 2015. Journal of medicinal chemistry. 58: 1569-1574

Preclinical pharmacology of FL442, a novel nonsteroidal androgen receptor modulator

Poutiainen Pekka K, Huhtala Tuulia, Jääskeläinen Tiina, Petsalo Aleksanteri, Küblbeck Jenni, Kaikkonen Sanna, Palvimo Jorma J, Raunio Hannu, Närvänen Ale, Peräkylä Mikael, Juvonen Risto O, Honkakoski Paavo, Laatikainen Reino, Pulkkinen Juha T. 2014. Molecular and cellular endocrinology. 387: 8-18

SUMO ligase PIAS1 functions as a target gene selective androgen receptor coregulator on prostate cancer cell chromatin

Toropainen Sari, Malinen Marjo, Kaikkonen Sanna, Rytinki Miia, Jääskeläinen Tiina, Sahu Biswajyoti, Jänne Olli A, Palvimo Jorma J. 2014. Nucleic acids research. 2015; 43: 848-861

Serum androgen bioactivity is low in children with premature adrenarche

Liimatta Jani, Laakso Saila, Utriainen Pauliina, Voutilainen Raimo, Palvimo Jorma J, Jääskeläinen Tiina, Jääskeläinen Jarmo. 2014. Pediatric research. 75: 645-650

Genetic predisposition to obesity and lifestyle factors - the combined analyses of twenty-six known BMI- and fourteen known waist:hip ratio (WHR)-associated variants in the Finnish Diabetes Prevention Study

Jääskeläinen T, Paananen J, Lindström J, Eriksson JG, Tuomilehto J, Uusitupa M. 2013. British journal of nutrition. 110: 1856-1965

FoxA1 corrupts the antiandrogenic effect of bicalutamide but only weakly attenuates the effect of MDV3100 (Enzalutamide)

Belikov S, Öberg C, Jääskeläinen T, Rahkama V, Palvimo JJ, Wrange Ö. 2012. Molecular and cellular endocrinology. -: -

Histone H2B ubiquitin ligases RNF20 and RNF40 in androgen signaling and prostate cancer cell growth

Jääskeläinen T, Makkonen H, Visakorpi T, Jaehoon K, Roeder RG, Palvimo JJ. 2012. Molecular and cellular endocrinology. 350: 87-98

Proto-oncogene PIM-1 is a novel estrogen receptor target associating with high grade breast tumors

Malinen M, Jääskeläinen T, Pelkonen M, Heikkinen S, Väisänen S, Kosma VM, Nieminen K, Mannermaa A, Palvimo JJ. 2012. Molecular and cellular endocrinology. 2013; 365: 270-276

Androgen receptor amplification is reflected in the transcriptional responses of Vertebral-Cancer of the Prostate cells

Makkonen H, Kauhanen M, Jääskeläinen T, Palvimo JJ. 2011. Molecular and cellular endocrinology. 331: 57-65

Steroid up-regulation of FKBP51 and its role in hormone signaling

Jääskeläinen T, Makkonen H, Palvimo JJ. 2011. Current opinion in pharmacology. 11: 326-331

Androgen receptor amplification is reflected in the transcriptional responses of Vertebral-Cancer on the prostate cells

Makkonen H, Kauhanen M, Jääskeläinen T & Palvimo JJ. 2010. Molecular and cellular endocrinology. 331: 57-65

Glucocorticoid receptor activates poised FKBP51 locus through long-distance interactions

Paakinaho V, Makkonen H, Jääskeläinen T & Palvimo JJ. 2010. Molecular endocrinology. 24: 511-525

Long-range activation of FKBP51 transkription by the androgen receptor via distal intronic enhancers

Makkonen H, Kauhanen M, Paakinaho V, Jääskeläinen T, Palvimo JJ. 2009. Nucleic acids research. 37: 4135-4148

PIAS proteins: pleiotropic interactors associated with SUMO

Rytinki MM, Kaikkonen S, Pehkonen P, Jääskeläinen T, Palvimo JJ. 2009. Cellular and molecular life sciences. 66: 3029-3041

SUMO-specific protease 1 (SENP1) reverses the hormone-augmented SUMOylaiton of androgen receptor and moulates gene responses in prostate cancer cells

Kaikkonen S, Jääskeläinen T, Karvonen U, Rytinki MM, Makkonen H, Gioeli D, Paschal BM, Palvimo JJ. 2009. Molecular endocrinology. 23: 292-307

Identification of ETS-like transcription factor as a novel androgen receptor target in prostate cancer cells

Makkonen H, Jääskeläinen T, Pitkänen-Arsiola T, Rytinki M, Waltering KK, Mättö M, Visakorpi T, Palvimo JJ. 2008. Oncogene. 27: 4865-4876

Leukemia inhibitory factor as a regulator of steroidogenesis in human NCI-H295R adrenocortical cells

Mikhaylova IV, Jääskeläinen T, Jääskeläinen J, Palvimo JJ, Voutilainen R. 2008. Journal of endocrinology. 199: 435-444

ZNF451 is a novel PML body- and SUMO-associated transcriptional coregulator

Karvonen U, Jääskeläinen T, Rytinki M, Kaikkonen S, Palvimo JJ. 2008. Journal of molecular biology. 382: 585-600

Negative regulation of human parathyroid hormone gene promoter by Vitamin D3 through nuclear factor Y

Jääskeläinen T, Huhtakangas J, Mäenpää PH. 2005. Biochemical and biophysical research communications. 328: 831-837

9-cis retinoic acid accelerates calcitriol-induced osteocalcin production and promotes degradation of both vitamin D receptor and retinoid x receptor in human osteoblastic cells

Jääskeläinen T, Ryhänen S, Mäenpää PH. 2003. Journal of cellular biochemistry. 89: 1164-1176

Inhibition of MG-63 cell cycle progression by synthetic vitamin D3 analogs mediated by p27, Cdk2, cyclin E, and the retinoblastoma protein

Ryhänen S, Jääskeläinen T, Mahonen A, Mäenpää P. 2003. Biochemical pharmacology. 66: 495-504

Mechanism of action of superactive vitamin D analogs through regulated receptor degradation

Mäenpää PH, Jääskeläinen T, Ryhänen S, Mahonen A. Teoksessa: Tsambaos D, Merk H(toim.) , 2002. Modern Trends in Skin Pharmacology. s. 22-26. Parissianos Medical Publications

Vitamin D3 analogs (MC 1288, KH 1060, EB 1089, GS 1558, and CB 1093): studies on their mechanism of action

Mäenpää PH, Väisänen S, Jääskeläinen T, Ryhänen S, Rouvinen J, Duchier C, Mahonen A. 2001. Steroids. 66: 223-225

Mechanism of action of 20-epi analogs of 1alfa, 25(OH)2D3 with respect to activation of gene transcription

Mäenpää PH, Väisänen S, Jääskeläinen T, Ryhänen S. Teoksessa: Norman AW, Bouillon R, Thomasset M(toim.) , 2000. Vitamin D Endocrine System. Structural, Biological, Genetic and Clinical Aspects. Proceedings of the Eleventh Workshop on Vitamin D. s. 215-221. University of California, Printing and Reprographics

Mechanism of action of superactive vitamin D analogs through regulated receptor degradation

Jääskeläinen T, Ryhänen S, Mahonen A, DeLuca HF, Mäenpää PH. 2000. Journal of cellular biochemistry. 76: 548-558

Regulation of vitamin D receptor protein levels and transactivation by 9-cis retinoic acid

Jääskeläinen T, Ryhänen S, Mäenpää PH. Teoksessa: Norman AW, Bouillon R, Thomasset M(toim.) , 2000. Vitamin D Endocrine System. Structural, Biological, Genetic and Clinical Aspects. Proceedings of the Eleventh Workshop on Vitamin D. s. 283-286. University of California, Printing and Reprographics

Inhibition of proliferation and induction of differentiation of osteoblastic cells by a novel 1,25-dihydroxyvitamin D3 analog with an extensively modified side chain (CB1093)

Ryhänen S, Jääskeläinen T, Saarela JTA, Mäenpää PH. 1998. Journal of cellular biochemistry. 70: 414-424

Gene Expression Regulated by Vitamin D in Bone Cells. Interactions of Vitamin D Receptor with its DNA Response Elements

Jääskeläinen T. 1997. Kuopion yliopiston julkaisuja C. Luonnontieteet ja ympäristötieteet

State of methylation of the human osteocalcin gene in bone-derived and other types of cells

Ryhänen S, Pirskanen A, Jääskeläinen T, Mäenpää PH. 1997. Journal of cellular biochemistry. 66: 404-412

A novel vitamin D analog with two double bonds in its side chain. A potent inducer of osteoblastic cell differentiation

Mahonen A, Jääskeläinen T, Mäenpää PH. 1996. Biochemical pharmacology. 51: 887-892

Synthetic 20-epi analogs of calcitriol are potent inducers of target-gene activation in osteoblastic cells

Ryhänen S, Mahonen A, Jääskeläinen T, Mäenpää PH. 1996. Febs journal. 238: 97-103

Effects of a new vitamin D analog, EB 1089, on osteoblastic cells

Mäenpää PH, Jääskeläinen T, Mahonen A. 1995. Annals of the New York Academy of Sciences. 761: 349-350

Retinoid-X-receptor-alpha-independent binding of vitamin D receptor to its response element from human osteocalcin gene

Jääskeläinen T, Itkonen A, Mäenpää PH. 1995. Febs journal. 228: 222-228

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Tiina Jääskeläinen

Keywords

Lack of androgen receptor SUMOylation results in male infertility due to epididymal dysfunction

ZNHIT3 is defective in PEHO syndrome, a severe encephalopathy with cerebellar granule neuron loss

Chemoproteomic, biochemical and pharmacological approaches in the discovery of inhibitors targeting human alfa/beta-hydrolase domain containing 11 (ABHD11)

Complete androgen insensitivity syndrome caused by a deep intronic pseudoexon-activating mutation in the androgen receptor gene

Androgen receptor- and PIAS1-regulated gene programs in molecular apocrine breast cancer cells

Synthesis and Biological Evaluation of Second-Generation Tropanol-Based Androgen Receptor Modulators

Preclinical pharmacology of FL442, a novel nonsteroidal androgen receptor modulator

SUMO ligase PIAS1 functions as a target gene selective androgen receptor coregulator on prostate cancer cell chromatin

Serum androgen bioactivity is low in children with premature adrenarche

Genetic predisposition to obesity and lifestyle factors - the combined analyses of twenty-six known BMI- and fourteen known waist:hip ratio (WHR)-associated variants in the Finnish Diabetes Prevention Study

FoxA1 corrupts the antiandrogenic effect of bicalutamide but only weakly attenuates the effect of MDV3100 (Enzalutamide)

Histone H2B ubiquitin ligases RNF20 and RNF40 in androgen signaling and prostate cancer cell growth

Proto-oncogene PIM-1 is a novel estrogen receptor target associating with high grade breast tumors

Androgen receptor amplification is reflected in the transcriptional responses of Vertebral-Cancer of the Prostate cells

Steroid up-regulation of FKBP51 and its role in hormone signaling

Androgen receptor amplification is reflected in the transcriptional responses of Vertebral-Cancer on the prostate cells

Glucocorticoid receptor activates poised FKBP51 locus through long-distance interactions

Long-range activation of FKBP51 transkription by the androgen receptor via distal intronic enhancers

PIAS proteins: pleiotropic interactors associated with SUMO

SUMO-specific protease 1 (SENP1) reverses the hormone-augmented SUMOylaiton of androgen receptor and moulates gene responses in prostate cancer cells

Identification of ETS-like transcription factor as a novel androgen receptor target in prostate cancer cells

Leukemia inhibitory factor as a regulator of steroidogenesis in human NCI-H295R adrenocortical cells

ZNF451 is a novel PML body- and SUMO-associated transcriptional coregulator

Negative regulation of human parathyroid hormone gene promoter by Vitamin D3 through nuclear factor Y

9-cis retinoic acid accelerates calcitriol-induced osteocalcin production and promotes degradation of both vitamin D receptor and retinoid x receptor in human osteoblastic cells

Inhibition of MG-63 cell cycle progression by synthetic vitamin D3 analogs mediated by p27, Cdk2, cyclin E, and the retinoblastoma protein

Mechanism of action of superactive vitamin D analogs through regulated receptor degradation

Vitamin D3 analogs (MC 1288, KH 1060, EB 1089, GS 1558, and CB 1093): studies on their mechanism of action

Mechanism of action of 20-epi analogs of 1alfa, 25(OH)2D3 with respect to activation of gene transcription

Mechanism of action of superactive vitamin D analogs through regulated receptor degradation

Regulation of vitamin D receptor protein levels and transactivation by 9-cis retinoic acid

Inhibition of proliferation and induction of differentiation of osteoblastic cells by a novel 1,25-dihydroxyvitamin D3 analog with an extensively modified side chain (CB1093)

Gene Expression Regulated by Vitamin D in Bone Cells. Interactions of Vitamin D Receptor with its DNA Response Elements

State of methylation of the human osteocalcin gene in bone-derived and other types of cells

A novel vitamin D analog with two double bonds in its side chain. A potent inducer of osteoblastic cell differentiation

Synthetic 20-epi analogs of calcitriol are potent inducers of target-gene activation in osteoblastic cells

Effects of a new vitamin D analog, EB 1089, on osteoblastic cells

Retinoid-X-receptor-alpha-independent binding of vitamin D receptor to its response element from human osteocalcin gene