
TUOMO KEINäNEN
Grant-funded Researcher
PhD, Adjunct professor chemical biology, project reseacher
I apply a chemical-biological approach to the implementation of business and basic research projects supported by various funders.
I also have long-term basic research experience in the study of biogenic amines (cell growth and differentiation at the molecular / macromolecular level) and in the application of basic research to the development / prevention of diabetes-related organ damage and the early diagnosis of cancer using various molecular markers. The re-allocation of drugs to new therapeutic areas and the study of their new targets have been part of my research history. I also have project-based know-how from recycled rubber, microplastic and biofilters. Recently, I have used a Gilson PLC-2250 with a CPC1000 unit to isolate phenolic fractions from the slow pyrolysis fluids.
Contact info
Organization
Faculty of Health Sciences, School of Pharmacy
tuomo.keinanen@uef.fi
Phone
+358 40 355 2387
Keywords
Teaching Activities
Research groups and research projects
Releases in SoleCRIS
Research groups - UEF
Links
Publications
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Hyvönen, Mervi T; Khomutov, Maxim; Vepsäläinen, Jouko; Khomutov, Alex R; Keinänen, Tuomo A. 2021. α-Difluoromethylornithine-Induced Cytostasis is Reversed by Exogenous Polyamines, Not by Thymidine Supplementation Biomolecules 11 5: 707. 2021
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Khandazhinskaya, Anastasia; Eletskaya, Barbara; Fateev, Ilja; Kharitonova, Maria; Konstantinova, Irina; Barai, Vladimir; Azhayev, Alex; Hyvonen, Mervi T.; Keinanen, Tuomo A.; Kochetkov, Sergey; Seley-Radtke, Katherine; Khomutov, Alex; Matyugina, Elena. 2021. Novel fleximer pyrazole-containing adenosine analogues: chemical, enzymatic and highly efficient biotechnological synthesis Organic and biomolecular chemistry 19 34: 7379-7389. 2021
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Castoldi, Francesca; Hyvönen, Mervi T; Durand, Sylvère; Aprahamian, Fanny; Sauvat, Allan; Malik, Shoaib A; Baracco, Elisa Elena; Vacchelli, Erika; Opolon, Paule; Signolle, Nicolas; Lefevre, Déborah; Bossut, Noelie; Eisenberg, Tobias; Dammbrueck, Christopher; Pendl, Tobias; Kremer, Margerie; Lachkar, Sylvie; Einer, Claudia; Michalke, Bernhard; Zischka, Hans et al. [incl. Keinänen, Tuomo]. 2020. Chemical activation of SAT1 corrects diet-induced metabolic syndrome Cell death and differentiation 27 10: 2904-2920. 2020
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Hyvönen, Mervi; Keinänen, Tuomo; Nuraeva, Gulgina; Yanvarev, Dmitry; Khomutov, Maxim; Khurs, Elena; Kochetkov, Sergey; Vepsäläinen, Jouko; Zhgun, Alexander; Khomutov, Alex. 2020. Hydroxylamine Analogue of Agmatine: Magic Bullet for Arginine Decarboxylase Biomolecules 10 3: 406. 2020
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Khomutov, MA; Hyvönen, MT; Salikhov, AI; Chizhov, AO; Ryzhov, IM; Kochetkov, SN; Vepsäläinen, J; Keinänen, TA; Khomutov, AR. 2020. Synthesis of (3R,10R)- and (3S,10S)-Diastereomers of 3,10-Dimethylspermine Russian journal of bioorganic chemistry 46 6: 686-692. 2020
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Khomutov, Maxim; Hyvönen, Mervi T; Simonian, Alina; Formanovsky, Andrey A; Mikhura, Irina V; Chizhov, Alexander O; Kochetkov, Sergey N; Alhonen, Leena; Vepsäläinen, Jouko; Keinänen, Tuomo A; Khomutov, Alex R. 2019. Unforeseen Possibilities To Investigate the Regulation of Polyamine Metabolism Revealed by Novel C-Methylated Spermine Derivatives Journal of medicinal chemistry 62 24: 11335-11347. 2019
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Ivanova, ON; Snezhkina, AV; Krasnov, GS; Valuev-Elliston, VT; Khomich, OA; Khomutov, AR; Keinanen, TA; Alhonen, L; Bartosch, B; Kudryavtseva, AV; Kochetkov, SN; Ivanov, AV. 2018. Activation of Polyamine Catabolism by N¹,N11-Diethylnorspermine in Hepatic HepaRG Cells Induces Dedifferentiation and Mesenchymal-Like Phenotype Cells 7 12: 275. 2018
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Keinänen, Tuomo A; Grigorenko, Nikolay; Khomutov, Alex R; Huang, Qingqiu; Uimari, Anne; Alhonen, Leena; Hyvönen, Mervi T; Vepsäläinen, Jouko. 2018. Controlling the regioselectivity and stereospecificity of FAD-dependent polyamine oxidases with the use of amine-attached guide molecules as conformational modulators Bioscience reports 38 4: BSR20180527. 2018
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Khomutov, Maxim A; Hyvönen, Mervi T; Simonian, Alina R; Weisell, Janne; Vepsäläinen, Jouko; Alhonen, Leena; Kochetkov, Sergey N; Keinänen, Tuomo A; Khomutov, Alex R. 2018. Acetylated derivatives of C-methylated analogues of spermidine: synthesis and interaction with N1-acetylpolyamine oxidase MENDELEEV COMMUNICATIONS 28 5: 479-481. 2018
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Ucal, Sebahat; Häkkinen, Merja R; Alanne, Aino-Liisa; Alhonen, Leena; Vepsäläinen, Jouko; Keinänen, Tuomo A; Hyvönen, Mervi T. 2018. Controlling of N-Alkylpolyamine Analogue Metabolism by Selective Deuteration BIOCHEMICAL JOURNAL 475 3: 663-676. 2018