TUOMO KEINäNEN

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Publications

• Hyvönen, Mervi; Keinänen, Tuomo; Nuraeva, Gulgina; Yanvarev, Dmitry; Khomutov, Maxim; Khurs, Elena; Kochetkov, Sergey; Vepsäläinen, Jouko; Zhgun, Alexander; Khomutov, Alex. 2020. Hydroxylamine Analogue of Agmatine: Magic Bullet for Arginine Decarboxylase Biomolecules 10 3: 406. 2020
• Khomutov, Maxim; Hyvönen, Mervi T; Simonian, Alina; Formanovsky, Andrey A; Mikhura, Irina V; Chizhov, Alexander O; Kochetkov, Sergey N; Alhonen, Leena; Vepsäläinen, Jouko; Keinänen, Tuomo A; Khomutov, Alex R. 2019. Unforeseen Possibilities To Investigate the Regulation of Polyamine Metabolism Revealed by Novel C-Methylated Spermine Derivatives Journal of medicinal chemistry 62 24: 11335-11347. 2019
• Ivanova, ON; Snezhkina, AV; Krasnov, GS; Valuev-Elliston, VT; Khomich, OA; Khomutov, AR; Keinanen, TA; Alhonen, L; Bartosch, B; Kudryavtseva, AV; Kochetkov, SN; Ivanov, AV. 2018. Activation of Polyamine Catabolism by N¹,N11-Diethylnorspermine in Hepatic HepaRG Cells Induces Dedifferentiation and Mesenchymal-Like Phenotype Cells 7 12: 275. 2018
• Keinänen, Tuomo A; Grigorenko, Nikolay; Khomutov, Alex R; Huang, Qingqiu; Uimari, Anne; Alhonen, Leena; Hyvönen, Mervi T; Vepsäläinen, Jouko. 2018. Controlling the regioselectivity and stereospecificity of FAD-dependent polyamine oxidases with the use of amine-attached guide molecules as conformational modulators Bioscience reports 38 4: BSR20180527. 2018
• Khomutov, Maxim A; Hyvönen, Mervi T; Simonian, Alina R; Weisell, Janne; Vepsäläinen, Jouko; Alhonen, Leena; Kochetkov, Sergey N; Keinänen, Tuomo A; Khomutov, Alex R. 2018. Acetylated derivatives of C-methylated analogues of spermidine: synthesis and interaction with N1-acetylpolyamine oxidase MENDELEEV COMMUNICATIONS 28 5: 479-481. 2018
• Ucal, Sebahat; Häkkinen, Merja R; Alanne, Aino-Liisa; Alhonen, Leena; Vepsäläinen, Jouko; Keinänen, Tuomo A; Hyvönen, Mervi T. 2018. Controlling of N-Alkylpolyamine Analogue Metabolism by Selective Deuteration BIOCHEMICAL JOURNAL 475 3: 663-676. 2018
• Niemi Riikka Johanna, Roine Antti N, Häkkinen Merja R, Kumpulainen Pekka S, Keinänen Tuomo A, Vepsäläinen Jouko J, Lehtimäki Terho, Oksala Niku K, Mäenpää Johanna U. 2017. Urinary Polyamines as Biomarkers for Ovarian Cancer. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER 27 7: 1360-1366. 2017
• Smirnova OA, Keinanen TA, Ivanova ON, Hyvonen MT, Khomutov AR, Kochetkov SN, Bartosch B, Ivanov AV. 2017. Hepatitis C virus alters metabolism of biogenic polyamines by affecting expression of key enzymes of their metabolism. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 483 2: 904-909. 2017
• Thomas TJ, Thomas Thresia, John Shali, Hsu Hui-Chen, Yang PingAr, Keinänen Tuomo A, Hyvönen Mervi T. 2016. Tamoxifen metabolite endoxifen interferes with the polyamine pathway in breast cancer. AMINO ACIDS 48 10: 2293-2302. 2016
• Hyvönen Mervi T, Ucal Sebahat, Pasanen Markku, Peräniemi Sirpa, Weisell Janne, Khomutov Maxim, Khomutov Alex R, Vepsäläinen Jouko, Alhonen Leena, Keinänen Tuomo A. 2016. Triethylenetetramine Modulates Polyamine and Energy Metabolism and Inhibits Cancer Cell Proliferation. BIOCHEMICAL JOURNAL 473 10: 1433-1441. 2016
• Khomutov MA, Keinanen Tuomo A, Hyvonen Mervi T, Weisell Janne, Vepsalainen Jouko, Alhonen Leena, Kochetkov SN, Khomutov AR. 2015. Enantioselective synthesis of (R)- and (S)-3-methylspermidines. RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY 41 5: 548-553. 2015
• Khomutov Maxim, Keinanen Tuomo A., Hyvonen Mervi T., Alhonen Leena, Vepsalainen Jouko, Khomutov Alex R.. 2015. Synthesis of biologically active analogues of spermine and spermidine.Springer. 1667. 2015
• Mäenpää Johanna Unelma, Niemi Riikka, Roine Antti, Häkkinen Merja, Kumpulainen Pekka, Keinänen Tuomo, Vepsäläinen Jouko, Lehtimäki Terho, Oksala Niku. 2015. Urinary acetylated polyamines in ovarian cancer. 5543. 2015
• Ruiz-Pérez M. Victoria, Medina Miguel Á, Urdiales José L, Keinänen Tuomo A, Sánchez-Jiménez Francisca. 2015. Polyamine metabolism is sensitive to glycolysis inhibition in human neuroblastoma cells. JOURNAL OF BIOLOGICAL CHEMISTRY 290 10: 6106-6119. 2015
• Hyvönen Mervi T, Khomutov Maxim, Petit Marine, Weisell Janne, Kochetkov Sergey N, Alhonen Leena, Vepsäläinen Jouko, Khomutov Alex R, Keinänen Tuomo A. 2015. Enantiomers of 3-Methylspermidine Selectively Modulate Deoxyhypusine Synthesis and Reveal Important Determinants for Spermidine Transport. ACS Chemical Biology 10 6: 1417-1424. 2015
• Keinanen TA, Hyvonen T, Vepsalainen J, Alhonen L, Khomutov AR, Janne J. 2014. Stable analogues of coenzyme-substrate complex of spermidine/spermine-N 1-acetyltransferase reaction. Synthesis and interaction with the enzyme. RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY 40: 155-161. 2014
• Khomutov MA, Weisell J, Hyvönen M, Keinänen TA, Vepsäläinen J, Alhonen L, Khomutov AR, Kochetkov SN. 2014. Hydroxylamine derivatives for regulation of spermine and spermidine metabolism. BIOCHEMISTRY (MOSCOW) 2013; 78 13: 1431-1446. 2014
• Roine Antti, Veskimäe Erik, Tuokko Antti, Kumpulainen Pekka, Koskimäki Juha, Keinänen Tuomo A, Häkkinen Merja R, Vepsäläinen Jouko, Paavonen Timo, Lekkala Jukka, Lehtimäki Terho, Tammela Teuvo L, Oksala Niku K. 2014. Detection of Prostate Cancer by an Electronic Nose: A Proof of Principle Study. JOURNAL OF UROLOGY 192: 230-235. 2014
• Weisell Janne, Hyvönen Mervi T, Alhonen Leena, Vepsäläinen Jouko, Keinänen Tuomo A, Khomutov Alex R. 2013. Charge deficient analogues of the natural polyamines. CURRENT PHARMACEUTICAL DESIGN 2014:20 2: 262-277. 2013
• Hyvönen Mervi T, Koponen Taina, Weisell Janne, Pietilä Marko, Khomutov Alex R, Vepsäläinen Jouko, Alhonen Leena, Keinänen Tuomo A. 2013. Spermidine promotes adipogenesis of 3T3-L1 cells by preventing interaction of ANP32 with HuR and PP2A. BIOCHEMICAL JOURNAL 453: 467-474. 2013
• Keinänen Tuomo A, Hyvönen Mervi T, Alhonen Leena, Vepsäläinen Jouko, Khomutov Alex R. 2013. Selective regulation of polyamine metabolism with methylated polyamine analogues. AMINO ACIDS 2014:46: 605-620. 2013
• Häkkinen Merja R, Roine Antti, Auriola Seppo, Tuokko Antti, Veskimäe Erik, Keinänen Tuomo A, Lehtimäki Terho, Oksala Niku, Vepsäläinen Jouko. 2013. Analysis of free, mono- and diacetylated polyamines from human urine by LC-MS/MS. JOURNAL OF CHROMATOGRAPHY. B. ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 941: 81-89. 2013
• Nayvelt I, John S, Hsu HC, Yang P, Liu W, Das G, Hyvönen MT, Alhonen L, Keinänen TA, Shirahata A, Patel R, Thomas T, Thomas TJ. 2012. A potential estrogen mimetic effect of a bis(ethyl)polyamine analogue on estrogen receptor positive MCF-7 breast cancer cells AMINO ACIDS 2012 Feb;42(2-3): 899-911. 2012
• Roine Antti, Tolvanen Mikko, Sipiläinen Miki, Kumpulainen Pekka, Helenius Merja A, Lehtimäki Terho, Vepsäläinen Jouko, Keinänen Tuomo A, Häkkinen Merja R, Koskimäki Juha, Veskimäe Erik, Tuokko Antti, Visakorpi Tapio, Tammela Teuvo L, Sioris Thanos, Paavonen Timo, Lekkala Jukka, Helle Hannu, Oksala Niku K. 2012. Detection of smell print differences between nonmalignant and malignant prostate cells with an electronic nose. FUTURE ONCOLOGY 8 9: 1157-1165. 2012
• Smirnova Olga A, Isaguliants Maria G, Hyvonen Mervi T, Keinanen Tuomo A, Tunitskaya Vera L, Vepsalainen Jouko, Alhonen Leena, Kochetkov Sergey N, Ivanov Alexander V. 2012. Chemically induced oxidative stress increases polyamine levels by activating the transcription of ornithine decarboxylase and spermidine/spermine-N1-acetyltransferase in human hepatoma HUH7 cells BIOCHIMIE 94 9: 1876-1883. 2012
• Hyvönen Mervi T, Weisell Janne, Khomutov Alex, Alhonen Leena, Vepsäläinen Jouko, Keinänen Tuomo A. 2012. Metabolism of triethylenetetramine and 1,12-diamino-3,6,9-triazadodecane by the spermidine/spermine-N1-acetyltransferase and thialysine acetyltransferase. DRUG METABOLISM AND DISPOSITION 2013:41: 30-32. 2012
• Hyvönen Mervi T, Uimari Anne, Vepsäläinen Jouko, Khomutov Alex R, Keinänen Tuomo A, Alhonen Leena. 2012. Tissue-specific alternative splicing of spermidine/spermine N1-acetyltransferase AMINO ACIDS 42: 485-493. 2012
• Hyvönen Mervi T, Keinänen Tuomo A, Khomutov Maxim, Simonian Alina, Vepsäläinen Jouko, Park Jong H, Khomutov Alex R, Alhonen Leena, Park Myung H. 2012. Effects of novel C-methylated spermidine analogs on cell growth via hypusination of eukaryotic translation initiation factor 5A. AMINO ACIDS 42: 685-695. 2012
• Cerrada-Gimenez Marc, Häkkinen Merja R, Vepsäläinen Jouko, Auriola Seppo, Alhonen Leena, Keinänen Tuomo A. 2012. Polyamine flux analysis by determination of heavy isotope incorporation from 13C, 15N-enriched amino acids into polyamines by LC-MS/MS AMINO ACIDS 42: 451-460. 2012
• Cerrada-Gimenez M, Pietilä Marko, Loimas Suvikki, Pirinen Eija , Hyvönen Mervi T, Keinänen Tuomo A, Jänne Juhani, Alhonen Leena. 2011. Continuous oxidative stress due to activation of polyamine catabolism accelerates aging and protects against hepatotoxic insults TRANSGENIC RESEARCH 20: 387-396. 2011
• Khomutov Alex R, Weisell Janne, Khomutov Maxim A, Grigorenko Nikolay A, Simonian Alina R, Häkkinen Merja R, Keinänen Tuomo A, Hyvönen Mervi T, Alhonen Leena, Kochetkov Sergey N, Vepsäinen Jouko. 2011. Methylated polyamines as research tools: Pegg, A.E. ja Casero, R.A. Jr., Polyamines. Methods and Protocols. Methods in Molecular Biology 720. 449-461. 2011
• Khomutov MA, Hyvönen MT, Simonian AR, Vepsäläinen J, Alhonen L, Kochetkov SN, Keinänen TA. 2011. Novel metabolically stable functionally active mimetic of spermidine RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY 37 2: 253-258. 2011
• Marc Cerrada-Gimenez, Janne Weisell, Mervi T. Hyvönen, Myung Hee Park, Leena Alhonen, Jouko Vepsäläinen, and Tuomo A. Keinänen. 2011. Complex N-Acetylation of Triethylentetramine. DRUG METABOLISM AND DISPOSITION 39 12: 2242-2249. 2011
• Mervi T. Hyvönen, Tuomo A. Keinänen, Maxim Khomutov, Alina Simonian, Janne Weisell, Sergey N. Kochetkov, Jouko Vepsäläinen, Leena Alhonen, and Alex R. Khomutov. 2011. The Use of Novel C-Methylated Spermidine Derivatives To Investigate the Regulation of Polyamine Metabolism JOURNAL OF MEDICINAL CHEMISTRY 54 13: 4611-4618. 2011
• Weisell J, Hyvönen MT, Vepsäläinen J, Alhonen L, Keinänen TA, Khomutov AR & Soininen P. 2010. Novel isosteric charge-deficient spermine analogue-1,12- diamino-3,6,9-triazadodecane: synthesis, pKa measurement and biological activity. AMINO ACIDS 38 2: 501-507. 2010
• Weisell J, Hyvönen MT, Häkkinen MR, Grigorenko NA, Pietilä M, Lampinen A, Kochetkov SN, Alhonen L, Vepsäläinen J, Keinänen TA et al. 2010. Synthesis and Biological Characterization of Novel Charge-Deficient Spermine Analogues. JOURNAL OF MEDICINAL CHEMISTRY 53 15: 5738-5748. 2010
• Vuohelainen S, Pirinen E, Cerrada-Gimenez M, Keinänen TA, Uimari A, Pietilä M, Khomutov AR, Jänne J & Alhonen L. 2010. Spermidine is indispensable in differentiation of 3T3-L1 fibroblasts to adipocytes. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 14 6b: 1683-1692. 2010
• Nayvelt I, Hyvönen MT, Alhonen L, Pandya I, Thomas T, Khomutov AR, Vepsäläinen J, Patel R, Keinänen TA & Thomas TJ. 2010. DNA condensation by chiral alpha-methylated polyamine analogues and protection of cellular DNA from oxidative damage. BIOMACROMOLECULES 11: 97-105. 2010
• Häkkinen M, Hyvönen MT, Auriola S, Casero RA Jr., Vepsäläinen J, Khomutov A, Alhonen L & Keinänen T. 2010. Metabolism of N-alkylated spermine analogues by polyamine and spermine oxidases. AMINO ACIDS 38: 369-381. 2010
• Fashe TM, Keinänen TA, Grigorenko NA, Khomutov AR, Jänne J, Alhonen L & Pietilä M. 2010. Cutaneous application of alpha-methylspermidine activates the growth of resting hair follicles in mice AMINO ACIDS 38: 583-590. 2010
• Hyvönen MT, Sinervirta R, Keinänen TA, Fashe T, Grigorenko NA, Khomutov AR, Vepsäläinen J & Alhonen L. 2010. Acute Pancreatitis Induced by Activated Polyamine Catabolism is Associated with Coagulopathy: Effect of a-Methylated Polyamines Analogs on Haemostasis PANCREATOLOGY 10: 208-221. 2010
• Hyvönen MT, Sinervirta R, Grigorenko N, Khomutov AR, Vepsäläinen J, Keinänen TA & Alhonen L. 2010. alpha-Methylspermidine protects against carbon tetrachloride-induced hepatic and pancreatic damage. AMINO ACIDS 38: 575-581. 2010
• Hyvönen MT, Howard MT, Anderson CB, Grigorenko N, Khomutov AR, Vepsäläinen J, Alhonen L, Jänne J, Keinänen TA. 2009. Divergent regulation of the key enzymes of polyamine metabolism by chiral alpha-methylated polyamine analogues BIOCHEMICAL JOURNAL 422: 321-328. 2009
• Häkkinen MR, Keinänen TA, Khomutov AR, Auriola S, Weisell J, Alhonen L, Jänne J, Vepsäläinen J. 2009. Synthesis of novel deuterium labelled derivates of N-alkylated polyamines. TETRAHEDRON 65 2: 547-562. 2009
• Khomutov AR, Keinanen TA, Grigorenko NA, Hyvonen MT, Uimari A, Pietila M, Cerrada-Gimenez M, Simonian AR, Khomutov MA, Vepsalainen J, Alhonen L, Janne J. 2009. Methylated analogs of spermine and spermidine as tools to investigate cellular functions of polyamines and the enzymes of their metabolism. MOLEKULIARNAIA BIOLOGIIA [MOSKVA] 43 2: 274-285. 2009
• Uimari A, Keinänen TA, Karppinen A, Woster P, Uimari P, Jänne J, Alhonen L.. 2009. Spermine analogue-regulated expression of spermidine/spermine N1-acetyltransferase and its effects on depletion of intracellular polyamine pools in mouse fetal fibroblasts. BIOCHEMICAL JOURNAL 422: 101-109. 2009
• Alhonen L, Uimari A, Pietilä M, Hyvönen MT, Pirinen E, Keinänen TA. 2009. Transgenic animals modelling polyamine metabolism-related diseases. ESSAYS IN BIOCHEMISTRY 46: 125-144. 2009
• Häkkinen MR, Keinänen TA, Vepsäläinen J, Khomutov AR, Alhonen L, Jänne J, Auriola S. 2008. Quantitative determination of underivatized polyamines by using isotope dilution RP-LC-ESI-MS/MS. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 48: 414-421. 2008
• Keinänen TA, Järvinen A, Uimari A, Vepsäläinen J, Khomutov AR, Grigorenko NA, Hyvönen MT, Cerrada-Gimenez M, Alhonen L, Jänne J. 2007. Alpha-methylated polyamines as potential drugs and experimental tools in enzymology. MINI REVIEWS IN MEDICINAL CHEMISTRY 7 8: 813-820. 2007
• Simonian A, Khomutov A, Hyvonen T, Grigorenko N, Keinanen T, Vepsalainen J, Alhonen L, Janne J. 2007. Novel CoA-polyamine conjugates for effective inhibition of spermine/spermidine-N1-acetyltransferase NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS 26: 1245-1248. 2007
• Merentie M, Uimari A, Pietilä M, Sinervirta R, Keinänen TA, Vepsäläinen J, Khomutov A, Grigorenko N, Herzig K-H, Jänne J, Alhonen L. 2007. Oxidative stress and inflammation in the pathogenesis of activated polyamine catabolism-induced acute pancreatitis AMINO ACIDS 33 2: 323-330. 2007
• Hyvönen MT, Keinänen TA, Cerrada-Gimenez M, Sinervirta R, Grigorenko N, Khomutov AR, Vepsäläinen J, Alhonen L, Jänne J. 2007. Role of hypusinated eukaryotic translation initiation factor 5A in polyamine depletion-induced cytostasis. JOURNAL OF BIOLOGICAL CHEMISTRY 282 48: 34700-34706. 2007
• Häkkinen MR, Keinänen TA, Vepsäläinen J, Khomutov AR, Alhonen L, Jänne J, Auriola S. 2007. Analysis of underivatized polyamines by reversed phase liquid chromatography with electorspray tandem mass spectrometry. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 45: 625-634. 2007
• Hyvönen MT, Merentie M, Uimari A, Keinänen TA, Jänne J, Alhonen L. 2007. Mechanisms of polyamine catabolism-induced acute pancreatitis. BIOCHEMICAL SOCIETY TRANSACTIONS 35: 326-330. 2007
• Grigorenko NA, Khomutov AR, Keinänen TA, Järvinen A, Alhonen L, Jänne J, Vepsäläinen J. 2007. Synthesis of novel optical isomers of [alpha]-methylpolyamines. TETRAHEDRON 63: 2257-2262. 2007
• Järvinen A, Keinänen TA, Grigorenko NA, Khomutov AR, Uimari A, Vepsäläinen J, Närvänen A, Alhonen L, Jänne J. 2006. Guide molecule-driven stereospecific degradation of alpha-methylpolyamines by polyamine oxidase. JOURNAL OF BIOLOGICAL CHEMISTRY 281 8: 4589-4595. 2006
• Niiranen K, Keinänen TA, Pirinen E, Heikkinen S, Tusa M, Fatrai S, Suppola S, Pietilä M, Uimari A, Laakso M, Alhonen L, Jänne J. 2006. Mice with targeted disruption of spermidine/spermine N1-acetyltransferese gene maintain nearly normal tissue polyamine homeostasis but show signs of insulin resistance upon aging JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 10: 933-945. 2006
• Järvinen AJ, Cerrada-Gimenez M, Grigorenko NA, Khomutov AR, Vepsäläinen JJ, Sinervirta RM, Keinänen TA, Alhonen LI, Jänne JE. 2006. Alpha-methyl polyamines: efficient synthesis and tolerance studies in vivo and in vitro. First evidence for dormant stereospecificity of polyamine oxidase. JOURNAL OF MEDICINAL CHEMISTRY 49: 399-406. 2006
• Jänne J, Alhonen L, Pietilä M, Keinänen TA, Suppola S, Pirinen E, Hyvönen MT, Järvinen A, Laakso M. 2006. Genetic engineering of polyamine catabolism in transgenic mice and rats: Wang J-Y, Casero RA Jr, Polyamine Cell Signaling. Physiology, Pharmacology, and Cancer Research.Humana Press. 465-477. 2006
• Jänne J, Alhonen L, Pietilä M, Keinänen TA, Uimari A, Hyvönen MT, Pirinen E. 2006. Genetic manipulation of polyamine catabolism in rodents. JOURNAL OF BIOCHEMISTRY 139 2: 155-160. 2006
• Hyvönen MT, Uimari A, Keinänen TA, Heikkinen S, Pellinen R, Wahlfors T, Korhonen A, Närvänen A, Wahlfors J, Alhonen L, Jänne J. 2006. Polyamine-regulated unproductive splicing and translation of spermidine/spermine N1 -acetyltransferase RNA (NEW YORK, N.Y.) 12 8: 1569-1582. 2006
• Hyvönen MT, Herzig K-H, Sinervirta R, Albrecht E, Nordback I, Sand J, Keinänen TA, Vepsäläinen J, Grigorenko N, Khomutov AR, Krüger B, Jänne J, Alhonen L. 2006. Activated polyamine catabolism in acute pancreatitis. Alpfa-methylated polyamine analogues prevent trypsinogen activation and pancreatitis-associated mortality. AMERICAN JOURNAL OF PATHOLOGY 168: 115-122. 2006
• Grigorenko NA, Vepsalainen JJ, Jarvinen A, Keinanen TA, Alhonen L, Janne J, Khomutov AR. 2005. Synthesis of (R)- and (S)-isomers of 1-methylspermidine MENDELEEV COMMUNICATIONS 15 4: 142-143. 2005
• Jänne J, Alhonen L, Keinänen TA, Pietilä M, Uimari A, Pirinen E, Hyvönen MT, Järvinen A. 2005. Animal disease models generated by genetic engineering of polyamine metabolism. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 9 4: 865-882. 2005
• Järvinen A, Grigorenko N, Khomutov AR, Hyvönen MT, Uimari A, Vepsäläinen J, Sinervirta R, Keinänen TA, Vujcic S, Alhonen L, Porter CW, Jänne J. 2005. Metabolic stability of alfa-methylated polyamine derivatives and their use as substitutes for the natural polyamines. JOURNAL OF BIOLOGICAL CHEMISTRY 280 8: 6595-6601. 2005
• Khomutov AR, Simonyan AR, Vepsalainen J, Keinanen TA, Alhonen L, Janne J. 2005. New oxaanalogues of spermine. RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY 31 2: 189-195. 2005
• Pietilä M, Pirinen E, Keskitalo S, Juutinen S, Pasonen-Seppänen S, Keinänen T, Alhonen L, Jänne J. 2005. Disturbed keratinocyte differentiation in transgenic mice and organotypic keratinocyte cultures as a result of spermidine/spermine N1-acetyltransferase overexpression. JOURNAL OF INVESTIGATIVE DERMATOLOGY 124 3: 596-601. 2005
• Jänne J, Alhonen L, Pietilä M, Keinänen TA. 2004. Genetic approaches to the cellular functions of polyamines in mammals. FEBS JOURNAL 271 2: 877-894. 2004
• Grigorenko NA, Vepsalainen J, Jarvinen A, Keinanen TT, Alhonen L, Janne J, Kritsyn AM, Khomutov AR. 2004. A new synthesis of alfa-methylspermidine RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY 30 4: 396-399. 2004
• Kaasinen SK, Gröhn OHJ, Keinänen TA, Alhonen L, Jänne J. 2003. Overexpression of spermidine/spermine N1-acetyltransferase elevates the threshold to pentylenetetrazol-induced seizure activity in transgenic mice. EXPERIMENTAL NEUROLOGY 183: 645-652. 2003
• Räsänen T-L, Alhonen L, Sinervirta R, Uimari A, Kaasinen K, Keinänen T, Herzig K-H, Jänne J. 2003. Gossypol activates pancreatic polyamine catabolism in normal rats and induces acute pancreatitis in transgenic rats over-expressing spermidine/spermine N1-acetyltransferase. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY 38: 787-793. 2003
• Räsänen T-L, Alhonen L, Sinervirta R, Keinänen T, Herzig K-H, Suppola S, Khomutov AR, Vepsäläinen J, Jänne J. 2002. A polyamine analogue prevents acute pancreatitis and restores early liver regeneration in transgenic rats with activated polyamine catabolism. JOURNAL OF BIOLOGICAL CHEMISTRY 277 42: 39867-39872. 2002
• Suppola S, Heikkinen S, Parkkinen JJ, Uusi-Oukari M, Korhonen V-P, Keinänen T, Alhonen L, Jänne J. 2001. Concurrent overexpression of ornithine decarboxylase and spermidine/spermine N1-acetyltransferase further accelerates the catabolism of hepatic polyamines in transgenic mice BIOCHEMICAL JOURNAL 358: 343-348. 2001
• Alhonen L, Parkkinen JJ, Keinänen T, Sinervirta R, Herzig K-H, Jänne J. 2000. Activation of polyamine catabolism in transgenic rats induces acute pancreatitis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 97 15: 8290-8295. 2000
• Keinänen TA. 1997. Aminooxy Analogues of Polyamines. Kuopion yliopiston julkaisuja D. Lääketiede. 1997
• Hyvönen T, Keinänen TA, Khomutov AR, Khomutov RM, Eloranta TO. 1995. Aminooxy analogues of spermidine evidence the divergent roles of the charged amino nitrogens in the cellular physiology of spermidine. LIFE SCIENCES 56 5: 349-360. 1995
• Korhonen V-P, Halmekytö M, Kauppinen L, Myöhänen S, Wahlfors J, Keinänen T, Hyvönen T, Alhonen L, Eloranta T, Jänne J. 1995. Molecular cloning of a cDNA encoding human spermine synthase. DNA AND CELL BIOLOGY 14 10: 841-847. 1995

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