I apply a chemical-biological approach to the implementation of projects highlighted by society, business and basic research which are supported by different fund giving organizations. I am working for the ERDF BioMahti project, funded mainly by the Regional Council of Pohjois-Savo. I study molecular world of the side streams originated from the food, horticulture and wood processing. The aim of the BioMahti-project is to obtain a comprehensive understanding of the small molecule world of differently processed biomaterials and to isolate molecular fractions or single molecules produced by different types of extraction (HPCCC, CPC) / chromatography (Flash and HPLC) methods. The BioMahti project utilizes up-to-date analytical equipment for organic (NMR, 2d-GC-MS) and inorganic compounds (TRXF, ICP-MS).
Molecule fractions or single molecules are suitably tested, e.g., as antimicrobial compounds, or tested for suitability for medical devices or food product flavorings.
I also have a long-standing basic research experience in the study of biogenic amines (on cell growth and differentiation at molecular / macromolecular level) and the application of basic research to the development / prevention of diabetes-induced organ injury and early diagnosis of cancer. Re-allocation of drugs to new therapies and research into their novel macromolecule targets has been part of my research history. I have project-based expertise in recycled rubber, microplastic fiber and biofilt..
Faculty of Health Sciences, School of Pharmacy
Hyvönen, Mervi; Keinänen, Tuomo; Nuraeva, Gulgina; Yanvarev, Dmitry; Khomutov, Maxim; Khurs, Elena; Kochetkov, Sergey; Vepsäläinen, Jouko; Zhgun, Alexander; Khomutov, Alex. 2020. Hydroxylamine Analogue of Agmatine: Magic Bullet for Arginine Decarboxylase Biomolecules 10 3: 406. 2020
Khomutov, Maxim; Hyvönen, Mervi T; Simonian, Alina; Formanovsky, Andrey A; Mikhura, Irina V; Chizhov, Alexander O; Kochetkov, Sergey N; Alhonen, Leena; Vepsäläinen, Jouko; Keinänen, Tuomo A; Khomutov, Alex R. 2019. Unforeseen Possibilities To Investigate the Regulation of Polyamine Metabolism Revealed by Novel C-Methylated Spermine Derivatives Journal of medicinal chemistry 62 24: 11335-11347. 2019
Ivanova, ON; Snezhkina, AV; Krasnov, GS; Valuev-Elliston, VT; Khomich, OA; Khomutov, AR; Keinanen, TA; Alhonen, L; Bartosch, B; Kudryavtseva, AV; Kochetkov, SN; Ivanov, AV. 2018. Activation of Polyamine Catabolism by N¹,N11-Diethylnorspermine in Hepatic HepaRG Cells Induces Dedifferentiation and Mesenchymal-Like Phenotype Cells 7 12: 275. 2018
Keinänen, Tuomo A; Grigorenko, Nikolay; Khomutov, Alex R; Huang, Qingqiu; Uimari, Anne; Alhonen, Leena; Hyvönen, Mervi T; Vepsäläinen, Jouko. 2018. Controlling the regioselectivity and stereospecificity of FAD-dependent polyamine oxidases with the use of amine-attached guide molecules as conformational modulators Bioscience reports 38 4: BSR20180527. 2018
Khomutov, Maxim A; Hyvönen, Mervi T; Simonian, Alina R; Weisell, Janne; Vepsäläinen, Jouko; Alhonen, Leena; Kochetkov, Sergey N; Keinänen, Tuomo A; Khomutov, Alex R. 2018. Acetylated derivatives of C-methylated analogues of spermidine: synthesis and interaction with N1-acetylpolyamine oxidase MENDELEEV COMMUNICATIONS 28 5: 479-481. 2018
Ucal, Sebahat; Häkkinen, Merja R; Alanne, Aino-Liisa; Alhonen, Leena; Vepsäläinen, Jouko; Keinänen, Tuomo A; Hyvönen, Mervi T. 2018. Controlling of N-Alkylpolyamine Analogue Metabolism by Selective Deuteration BIOCHEMICAL JOURNAL 475 3: 663-676. 2018
Niemi Riikka Johanna, Roine Antti N, Häkkinen Merja R, Kumpulainen Pekka S, Keinänen Tuomo A, Vepsäläinen Jouko J, Lehtimäki Terho, Oksala Niku K, Mäenpää Johanna U. 2017. Urinary Polyamines as Biomarkers for Ovarian Cancer. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER 27 7: 1360-1366. 2017
Smirnova OA, Keinanen TA, Ivanova ON, Hyvonen MT, Khomutov AR, Kochetkov SN, Bartosch B, Ivanov AV. 2017. Hepatitis C virus alters metabolism of biogenic polyamines by affecting expression of key enzymes of their metabolism. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 483 2: 904-909. 2017
Thomas TJ, Thomas Thresia, John Shali, Hsu Hui-Chen, Yang PingAr, Keinänen Tuomo A, Hyvönen Mervi T. 2016. Tamoxifen metabolite endoxifen interferes with the polyamine pathway in breast cancer. AMINO ACIDS 48 10: 2293-2302. 2016
Hyvönen Mervi T, Ucal Sebahat, Pasanen Markku, Peräniemi Sirpa, Weisell Janne, Khomutov Maxim, Khomutov Alex R, Vepsäläinen Jouko, Alhonen Leena, Keinänen Tuomo A. 2016. Triethylenetetramine Modulates Polyamine and Energy Metabolism and Inhibits Cancer Cell Proliferation. BIOCHEMICAL JOURNAL 473 10: 1433-1441. 2016
Supervising practical exercises at the chemisty lab
Research groups and research projects