Tuulia Tynkkynen

Clinical and biochemical associations of urinary metabolites: quantitative epidemiological approach on renal-cardiometabolic biomarkers

Li, Tianqi; Ihanus, Andrei; Ohukainen, Pauli; Järvelin, Marjo-Riitta; Kähönen, Mika; Kettunen, Johannes; Raitakari, Olli T; Lehtimäki, Terho; Mäkinen, Ville-Petteri; Tynkkynen, Tuulia; Ala-Korpela, Mika. 2023. International journal of epidemiology. 2024; 53:

Salivary Metabolomics in the Diagnosis and Monitoring of Neurodegenerative Dementia

Hyvärinen, Eelis; Solje, Eino; Vepsäläinen, Jouko; Kullaa, Arja; Tynkkynen, Tuulia. 2023. Metabolites. 13:

Simple and User-Friendly Methodology for Crystal Water Determination by Quantitative Proton NMR Spectroscopy in Deuterium Oxide

Tynkkynen, Tuulia; Vassaki, Maria; Tiihonen, Tommi E.; Lehto, Vesa-Pekka; Demadis, Konstantinos D.; Turhanen, Petri A.. 2023. Analytical chemistry. 95: 17020-17027

Syljen metabolomiikan sovellutuksia suulääketieteellisessä tutkimuksessa

Hyvärinen, Eelis; Solje, Eino; Vepsäläinen, Jouko; Kullaa, Arja; Tynkkynen, Tuulia. 2023. Suomen hammaslääkärilehti. 30: 27

Characteristics of Normalization Methods in Quantitative Urinary Metabolomics — Implications for Epidemiological Applications and Interpretations

Li, Tianqi; Tynkkynen, Tuulia; Ihanus, Andrei; Zhao, Siyu; Mäkinen, Ville-Petteri; Ala-Korpela, Mika. 2022. Biomolecules. 12:

There is always glucose in normal urine: unspecific excretion associated with serum glucose and glomerular filtration rate

Li, Tianqi; Ihanus, Andrei; Ohukainen, Pauli; Järvelin, Marjo-Riitta; Kettunen, Johannes; Mäkinen, Ville-Petteri; Tynkkynen, Tuulia; Ala-Korpela, Mika. 2022. International journal of epidemiology. 51: 2022-2025

Tailored Synthesis of PEGylated Bismuth Nanoparticles for X-ray Computed Tomography and Photothermal Therapy: One-Pot, Targeted Pyrolysis, and Self-Promotion

Xu, Wujun; Cui, Pang; Happonen, Emilia; Leppänen, Jukka; Liu, Lizhi; Rantanen, Jimi; Majda, Dorota; Saukko, Annina; Thapa, Rinez; Nissinen, Tuomo; Tynkkynen, Tuulia; Töyräs, Juha; Fan, Li; Liu, Wenchao; Lehto, Vesa-Pekka. 2020. Acs applied materials and interfaces. 12: 47233-47244

Proof of concept for quantitative urine NMR metabolomics pipeline for large-scale epidemiology and genetics

Tynkkynen, T; Wang, Q; Ekholm, J; Anufrieva, O; Ohukainen, P; Vepsäläinen, J; Männikkö, M; Keinänen-Kiukaanniemi, S; Holmes, MV; Goodwin, M; Ring, S; Chambers, JC; Kooner, J; Järvelin, MR; Kettunen, J; Hill, M; Davey Smith, G; Ala-Korpela, M. 2019. International journal of epidemiology. 48: 978-993

Effects of hormonal contraception on systemic metabolism: cross-sectional and longitudinal evidence

Wang Qin, Würtz Peter, Auro Kirsi, Morin-Papunen Laure, Kangas Antti J, Soininen Pasi, Tiainen Mika, Tynkkynen Tuulia, Joensuu Anni, Havulinna Aki S, Aalto Kristiina, Salmi Marko, Blankenberg Stefan, Zeller Tanja, Viikari Jorma, Kähönen Mika, Lehtimäki Terho, Salomaa Veikko, Jalkanen Sirpa, Järvelin Marjo-Riitta et al. 2016. International journal of epidemiology. 45: 1445-1457

Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA

Kettunen Johannes, Demirkan Ayse, Würtz Peter, Draisma Harmen H, Haller Toomas, Rawal Rajesh, Vaarhorst Anika, Kangas Antti J, Lyytikäinen Leo-Pekka, Pirinen Matti, Pool René, Sarin Antti-Pekka, Soininen Pasi, Tukiainen Taru, Wang Qin, Tiainen Mika, Tynkkynen Tuulia, Amin Najaf, Zeller Tanja, Beekman Marian et al. 2016. Nature communications. 7: 11122

Metabolite profiling and cardiovascular event risk: a prospective study of 3 population-based cohorts

Würtz Peter, Havulinna Aki S, Soininen Pasi, Tynkkynen Tuulia, Prieto-Merino David, Tillin Therese, Ghorbani Anahita, Artati Anna, Wang Qin, Tiainen Mika, Kangas Antti J, Kettunen Johannes, Kaikkonen Jari, Mikkilä Vera, Jula Antti, Kähönen Mika, Lehtimäki Terho, Lawlor Debbie A, Gaunt Tom R, Hughes Alun D et al. 2015. Circulation. 131: 774-785

Sex hormone-binding globulin associations with circulating lipids and metabolites and the risk for type 2 diabetes: observational and causal effect estimates

Wang Qin, Kangas Antti J, Soininen Pasi, Tiainen Mika, Tynkkynen Tuulia, Puukka Katri, Ruokonen Aimo, Viikari Jorma, Kähönen Mika, Lehtimäki Terho, Salomaa Veikko, Perola Markus, Davey Smith George, Raitakari Olli T, Järvelin Marjo-Riitta, Würtz Peter, Kettunen Johannes, Ala-Korpela Mika. 2015. International journal of epidemiology. 44: 623-637

Comprehensive strategy for proton chemical shift prediction: linear prediction with nonlinear corrections

Laatikainen Reino, Hassinen Tommi, Lehtivarjo Juuso, Tiainen Mika, Jungman Juha, Tynkkynen Tuulia, Korhonen Samuli-Petrus, Niemitz Matthias, Poutiainen Pekka, Jääskeläinen Olli, Väisänen Topi, Weisell Janne, Soininen Pasi, Laatikainen Pekka, Martonen Henri, Tuppurainen Kari. 2014. Journal of chemical information and modeling. 54: 419-430

Metabolic signatures of adiposity in young adults: Mendelian randomization analysis and effects of weight change

Würtz Peter, Wang Qin, Kangas Antti J, Richmond Rebecca C, Skarp Joni, Tiainen Mika, Tynkkynen Tuulia, Soininen Pasi, Havulinna Aki S, Kaakinen Marika, Viikari Jorma S, Savolainen Markku J, Kähönen Mika, Lehtimäki Terho, Männistö Satu, Blankenberg Stefan, Zeller Tanja, Laitinen Jaana, Pouta Anneli, Mäntyselkä Pekka et al. 2014. PLoS medicine. 11: e1001765

High-throughput quantification of circulating metabolites improves prediction of subclinical atherosclerosis

Würtz Peter, Raiko Juho R, Magnussen Costan G, Soininen Pasi, Kangas Antti J, Tynkkynen Tuulia, Thomson Russell, Laatikainen Reino, Savolainen Markku J, Laurikka Jari, Kuukasjärvi Pekka, Tarkka Matti, Karhunen Pekka J, Jula Antti, Viikari Jorma S, Kähönen Mika, Lehtimäki Terho, Juonala Markus, Ala-Korpela Mika, Raitakari Olli T. 2012. European heart journal. 33: 2307-2316

Metabolic Diversity of Progressive Kidney Disease in 325 Patients with Type 1 Diabetes (the FinnDiane Study)

Mäkinen VP, Tynkkynen T, Soininen P, Peltola T, Kangas AJ, Forsblom C, Thorn LM, Kaski K, Laatikainen R, Ala-Korpela M, Groop PH. 2012. Journal of proteome research. 11: 1782-1790

Sphingomyelin is associated with kidney disease in type 1 diabetes (The FinnDiane Study)

Mäkinen Ville-Petteri, Tynkkynen Tuulia, Soininen Pasi, Forsblom Carol, Peltola Tomi, Kangas Antti J, Groop Per-Henrik, Ala-Korpela Mika. 2012. Metabolomics. 8: 369-375

¹H NMR Analysis of Serum Lipids

Tynkkynen Tuulia. 2012. Publications of the University of Eastern Finland. Dissertations in Forestry and Natural Sciences

¹H NMR spectral analysis and conformational behavior of n-alkanes in different chemical environments

Tynkkynen Tuulia, Hassinen Tommi, Tiainen Mika, Soininen Pasi, Laatikainen Reino. 2012. Magnetic resonance in chemistry. 50: 598-607

NMR protocol for determination of oxidation susceptibility of serum lipids and application of the protocol to a chocolate study

Tynkkynen Tuulia, Mursu Jaakko, Nurmi Tarja, Tuppurainen Kari, Laatikainen Reino, Soininen Pasi. 2011. Metabolomics. 8: 386-398

From proton nuclear magnetic resonance spectra to pH. assessment of 1H NMR pH indicator compound set for deuterium oxide solutions

Tynkkynen T, Tiainen M, Soininen P, Laatikainen R. 2009. Analytica chimica acta. : 105-112

High-throughput serum NMR metabonomics for cost effect holistic studies on systematic metabolism

Soininen P, Kangas AJ, Würtz P, Tukiainen T, Tynkkynen T, Laatikainen R, Järvelin M-R, Kähönen M, Lehtimäki T, Viikari J, Raitakari OT, Savolainen MJ, Ala-Korpela M. 2009. Analyst. : 1781-1785

A multi-metabolite analysis of serum by 1H NMR spectroscopy: Early systemic signs of Alzheimer's disease

Tukiainen T, Tynkkynen T, Mäkinen V-P, Jylänki P, Kangas A, Hokkanen J, Vehtari A, Gröhn O, Hallikainen M, Soininen H, Kivipelto M, Groop P-H, Kaski K, Laatikainen R, Soininen P, Pirttilä T, Ala-Korpela M, Soininen H, Pirttilä. 2008. Biochemical and biophysical research communications. 375: 356-361

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Publications

Clinical and biochemical associations of urinary metabolites: quantitative epidemiological approach on renal-cardiometabolic biomarkers

Salivary Metabolomics in the Diagnosis and Monitoring of Neurodegenerative Dementia

Simple and User-Friendly Methodology for Crystal Water Determination by Quantitative Proton NMR Spectroscopy in Deuterium Oxide

Syljen metabolomiikan sovellutuksia suulääketieteellisessä tutkimuksessa

Characteristics of Normalization Methods in Quantitative Urinary Metabolomics — Implications for Epidemiological Applications and Interpretations

There is always glucose in normal urine: unspecific excretion associated with serum glucose and glomerular filtration rate

Tailored Synthesis of PEGylated Bismuth Nanoparticles for X-ray Computed Tomography and Photothermal Therapy: One-Pot, Targeted Pyrolysis, and Self-Promotion

Proof of concept for quantitative urine NMR metabolomics pipeline for large-scale epidemiology and genetics

Effects of hormonal contraception on systemic metabolism: cross-sectional and longitudinal evidence

Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA

Metabolic profiling of alcohol consumption in 9778 young adults

Metabolic profiling of pregnancy: cross-sectional and longitudinal evidence

Metabolic signatures of birthweight in 18 288 adolescents and adults

Metabolomic Profiling of Statin Use and Genetic Inhibition of HMG-CoA Reductase

Metabolite profiling and cardiovascular event risk: a prospective study of 3 population-based cohorts

Sex hormone-binding globulin associations with circulating lipids and metabolites and the risk for type 2 diabetes: observational and causal effect estimates

Comprehensive strategy for proton chemical shift prediction: linear prediction with nonlinear corrections

Metabolic signatures of adiposity in young adults: Mendelian randomization analysis and effects of weight change

High-throughput quantification of circulating metabolites improves prediction of subclinical atherosclerosis

Metabolic Diversity of Progressive Kidney Disease in 325 Patients with Type 1 Diabetes (the FinnDiane Study)

Sphingomyelin is associated with kidney disease in type 1 diabetes (The FinnDiane Study)

¹H NMR Analysis of Serum Lipids

¹H NMR spectral analysis and conformational behavior of n-alkanes in different chemical environments

NMR protocol for determination of oxidation susceptibility of serum lipids and application of the protocol to a chocolate study

From proton nuclear magnetic resonance spectra to pH. assessment of 1H NMR pH indicator compound set for deuterium oxide solutions

High-throughput serum NMR metabonomics for cost effect holistic studies on systematic metabolism

A multi-metabolite analysis of serum by 1H NMR spectroscopy: Early systemic signs of Alzheimer's disease