Ville Leinonen

A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer's disease

Oh, Hamilton Se‐Hwee; Urey, Deniz Yagmur; Karlsson, Linda; Zhu, Zeyu; Shen, Yuanyuan; Farinas, Amelia; Timsina, Jigyasha; Duggan, Michael R; Chen, Jingsha; Guldner, Ian H; Morshed, Nader; Yang, Chengran; Western, Daniel; Ali, Muhammad; Guen, Yann Le; Trelle, Alexandra N.; Herukka, Sanna‐Kaisa; Rauramaa, Tuomas; Hiltunen, Mikko; Lipponen, Anssi; Luikku, Antti J; Poston, Kathleen L.; Mormino, Elizabeth C.; Wagner, Anthony D.; Wilson, Ted N.; Channappa, Divya; Leinonen, Ville; Stevens, Beth; Ehrenb, 2025, Alzheimer's & dementia. Poster

A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer’s disease

Oh, Hamilton Se Hwee; Urey, Deniz Yagmur; Karlsson, Linda; Zhu, Zeyu; Shen, Yuanyuan; Farinas, Amelia; Timsina, Jigyasha; Duggan, Michael R.; Chen, Jingsha; Guldner, Ian H.; Morshed, Nader; Yang, Chengran; Western, Daniel; Ali, Muhammad; Le Guen, Yann; Trelle, Alexandra; Herukka, Sanna Kaisa; Rauramaa, Tuomas; Hiltunen, Mikko; Lipponen, Anssi; Luikku, Antti J.; Poston, Kathleen L.; Mormino, Elizabeth; Wagner, Anthony D.; Wilson, Edward N.; Channappa, Divya; Leinonen, Ville; Stevens, Beth; Ehrenb, 2025, Nature medicine, 31, 5, 1592-1603. A1 Journal article (refereed), original research

Ageing and higher BMI explain movement control impairment distinctly better than chronic pain and its contributing factors: A cross-sectional study of 161 subjects with chronic low back pain and 42 pain-free controls

Mikkonen, Jani; Reito, Aleksi; Luomajoki, Hannu; Airaksinen, Olavi; Takatalo, Jani; Pesonen, Janne; Leinonen, Ville, 2025, Journal of back and musculoskeletal rehabilitation, 38, 3, 605-615. A1 Journal article (refereed), original research

Alaselkäkivun Käypä hoito -suositus : kohti kokonaisvaltaisempaa hoitoa ja kuntoutusta

Karppinen, Jaro; Holopainen, Riikka; Simula, Anna Sofia; Leinonen, Ville; Määttä, Juhani, 2025, Duodecim, 141, 19, 1541-1542. D1 Article in a trade journal

Altered tear fluid protein expression in persons with mild Alzheimer's disease in proteins involved in oxidative stress, protein synthesis, and energy metabolism

Kärkkäinen, Virve; Saari, Toni; Hannonen, Sanna; Rusanen, Minna; Lehtola, Juha-Matti; Uusitalo, Hannu; Leinonen, Ville; Thiede, Bernd; Kaarniranta, Kai; Koivisto, Anne M; Utheim, Tor P, 2025, Journal of Alzheimer's disease, 105, 1, 292-301. A1 Journal article (refereed), original research

Biopsies from Idiopathic Normal Pressure Hydrocephalus Patients as a Window to the Events of Early Alzheimer's disease: Beta‐amyloid and Tau Pathologies Alter Synaptic Transmission in Human Brain

Dougalis, Antonios; Abushik, Polina; Pelkonen, Anssi; Giudice, Luca; Gomez‐Budia, Mireia; Novosolova, Nataliia; Välimäki, Nelli‐Noora; Rezaie, Mohammad; Nurkhametova, Dilyara; Giniatullina, Raisa; Shakirzyanova, Anastasia; Mali, Akash; de Kock, Christiaan PJ; Mertens, Eline J; Mansvelder, Huibert D; Stevens, Beth; Macosko, Evan; Hiltunen, Mikko; Rauramaa, Tuomas; Leinonen, Ville; Malm, Tarja, 2025, Alzheimer's & dementia. Abstract

Cerebrospinal fluid proteome profiling across the Alzheimer’s disease continuum: a step towards solving the equation for ‘X’

Weiner, Sophia; Sauer, Mathias; Montoliu-Gaya, Laia; Benedet, Andrea L; Ashton, Nicholas J; Gonzalez-Ortiz, Fernando; Simrén, Joel; Rahmouni, Nesrine; Tissot, Cecile; Therriault, Joseph; Servaes, Stijn; Stevenson, Jenna; Leinonen, Ville; Rauramaa, Tuomas; Hiltunen, Mikko; Rosa-Neto, Pedro; Blennow, Kaj; Zetterberg, Henrik; Gobom, Johan, 2025, Molecular neurodegeneration, 20, 1, 52. A1 Journal article (refereed), original research

Discovery of Novel CSF Clearance Mechanism of Idiopathic Normal Pressure Hydrocephalus and Alzheimer's Disease

Lipponen, Anssi; Heikkinen, Sami; Räsänen, Joel; Macosko, Evan; Malm, Tarja; Hiltunen, Mikko; Leinonen, Ville, 2025, Alzheimer's & dementia. Poster

Drainage Volume, Drainage Time, and Irrigation Volume in Chronic Subdural Hematoma

Knuutinen, Oula; Tommiska, Pihla; Schwartz, Christoph; Lönnrot, Kimmo; Luoto, Teemu; Leinonen, Ville; Koivisto, Timo; Tetri, Sami; Posti, Jussi P; Kivisaari, Riku; Raj, Rahul; on behalf of the FINISH Investigators, 2025, Neurosurgery, [Online ahead of print 2025 Dec 12], 1-8. A1 Journal article (refereed), original research

Effect of ventricular volume on cerebrospinal fluid Alzheimer's disease biomarkers in patients with idiopathic normal pressure hydrocephalus

Vanninen, Aleksi; Erkkilä, Lauri; Kokkola, Tarja; Selander, Tuomas; Koivisto, Anne M; Kokki, Merja; Musialowicz, Tadeusz; Lipponen, Anssi; Hiltunen, Mikko; Hakumäki, Juhana; Herukka, Sanna-Kaisa; Rauramaa, Tuomas; Leinonen, Ville, 2025, Journal of Alzheimer's disease, 105, 2, 397-406. A1 Journal article (refereed), original research

Failure to improve — identifying risk factors for poor functional recovery following chronic subdural hematoma surgery

Raj, Rahul; Tommiska, Pihla; Luoto, Teemu; Leinonen, Ville; Koivisto, Timo; Tetri, Sami; Posti, Jussi; Lönnrot, Kimmo, 2025, Age and ageing, 54, 3, afaf056. A1 Journal article (refereed), original research

Inflammation-induced lysosomal dysfunction in human iPSC-derived microglia is exacerbated by APOE 4/4 genotype

Hellén, Marianna; Weert, Isabelle; Müller, Stephan A.; Räsänen, Noora; Kettunen, Pinja; Lehtonen, Šárka; Peitz, Michael; Fließbach, Klaus; Takalo, Mari; Koskuvi, Marja; Lichtenthaler, Stefan F.; Leinonen, Ville; Ramirez, Alfredo; Kärkkäinen, Olli; Hiltunen, Mikko; Koistinaho, Jari; Rõlova, Taisia, 2025, Journal of neuroinflammation, 22, 1, 147. A1 Journal article (refereed), original research

Low prevalence of CWH43 variants among Finnish and Norwegian idiopathic normal pressure hydrocephalus patients: a cohort-based observational study

Räsänen, Joel; Helisalmi, Seppo; Heikkinen, Sami; Raivo, Joose; Korhonen, Ville E.; Martiskainen, Henna; Junkkari, Antti; Grenier-Boley, Benjamin; Bellenguez, Céline; Oinas, Minna; Avellan, Cecilia; Frantzen, Janek; Kotkansalo, Anna; Rinne, Jaakko; Ronkainen, Antti; Kauppinen, Mikko; von und zu Fraunberg, Mikael; Lönnrot, Kimmo; Satopää, Jarno; Perola, Markus; Koivisto, Anne M.; Julkunen, Valtteri; Portaankorva, Anne M.; Mannermaa, Arto; Soininen, Hilkka; Jääskeläinen, Juha E.; Lambert, Jean-Cha, 2025, Fluids and barriers of the cns, 22, 1, 17. A1 Journal article (refereed), original research

Monoallelic TYROBP deletion is a novel risk factor for Alzheimer’s disease

Martiskainen, Henna; Willman, Roosa-Maria; Harju, Päivi; Heikkinen, Sami; Heiskanen, Mette; Müller, Stephan A.; Sinisalo, Rosa; Takalo, Mari; Mäkinen, Petra; Kuulasmaa, Teemu; Pekkala, Viivi; Galván del Rey, Ana; Juopperi, Sini-Pauliina; Jeskanen, Heli; Kervinen, Inka; Saastamoinen, Kirsi; Niiranen, Marja; Heikkinen, Sami V.; Kurki, Mitja I.; Marttila, Jarkko; Mäkinen, Petri I.; Rostalski, Hannah; Hietanen, Tomi; Ngandu, Tiia; Lehtisalo, Jenni; Bellenguez, Céline; Lambert, Jean-Charles; Haass, C, 2025, Molecular neurodegeneration, 20, 1, 50. A1 Journal article (refereed), original research

Mortality and causes of death after surgery for chronic subdural hematoma: a post hoc study of the FINISH randomized trial

Tommiska, Pihla; Knuutinen, Oula; Lönnrot, Kimmo; Luoto, Teemu; Leinonen, Ville; Koivisto, Timo; Tetri, Sami; Posti, Jussi P; Raj, Rahul, 2025, Acta neurochirurgica, 167, 310. A2 Review article, Literature review, Systematic review

Multimodal approach to characterize surgically removed epileptogenic zone from patients with focal drug‐resistant epilepsy: From operating room to wet lab

Kyyriäinen, Jenni; Della Pietra, Adriana; Torkamani‐Azar, Mastaneh; Gómez‐Budia, Mireia; Abushik, Polina; Novosolova, Nataliia; Eronen, Henri; Narvaez, Omar; Paasonen, Ekaterina; Lezhneva, Vera; Pelkonen, Anssi; Saveleva, Liudmila; Huotarinen, Antti; Belevich, Ilya; Jokitalo, Eija; Kuopio Epilepsy Center Epilepsy Surgery Group; Jutila, Leena; Rauramaa, Tuomas; Immonen, Arto; Leinonen, Ville; Tohka, Jussi; Gröhn, Olli; Kälviäinen, Reetta; Malm, Tarja; Sierra, Alejandra, 2025, Epilepsia open, [First published: 05 December 2025], 1-16. A1 Journal article (refereed), original research

Neuroinflammation Markers in Tear Fluid of Mild Alzheimer’s Disease

Kärkkäinen, Virve; Saari, Toni; Rusanen, Minna; Uusitalo, Hannu; Leinonen, Ville; Thiede, Bernd; Kaarniranta, Kai; Koivisto, Anne M.; Utheim, Tor P., 2025, Journal of molecular neuroscience, 75, 2, 73. A1 Journal article (refereed), original research

Normaalipaineinen hydrokefalia

Leinonen, Ville; Koivisto, Anne, 2025, Hallikainen, Merja; Koivisto, Anne; Melkas, Susanna; Portaankorva, Anne; Rinne, Juha; Rosenvall, Ari, Muistisairaudet, 195-201. D2 Article in a professional book (incl. an introduction by the editor)

Outcome after Anterior Cervical Decompression and Fusion – A Nationwide FinSpine Register Study of Independent Predictors of Outcome at 12 Months after Surgery for Degenerative Cervical Spine

Klimko, Nikolai; Danner, Nils; Salo, Henri; Kotkansalo, Anna; Leinonen, Ville; Huttunen, Jukka, 2025, Spine, 50, 10, 664-671. A1 Journal article (refereed), original research

Outcome measures after anterior cervical decompression and fusion surgery -non-respondents do not bias the results: A Finnish spine register (FinSpine) study

Klimko, N; Danner, N; Salo, H; Malmivaara, A; Leinonen, V; Huttunen, J, 2025, Brain and spine, 5, 104179. A1 Journal article (refereed), original research

Rate and risk factors for shunt revision in pediatric patients with hydrocephalus during a 17-year study period: a retrospective, population-based study

Välimaa, Juho; Huuskonen, Terhi J; Tervonen, Joona; Leinonen, Ville; Rantala, Susanna, 2025, Childs nervous system, 41, 1, 316. A1 Journal article (refereed), original research

Remote Monitoring Acceptance in Elderly Neurological Patients: Examining Sociodemographic Factors in the Pre-Implementation Phase

Zadegan, Melika Azim; Aromaa, Eeva; Sahlstrom, Rosa; Montonen, Tero; Eriksson, Päivi; Leinonen, Ville, 2025, Home health care management and practice, [Epub ahead of print March 12, 2025], 1-7. A1 Journal article (refereed), original research

Restarting anticoagulation early versus late in patients with chronic subdural hematoma and atrial fibrillation (RELACS): a phase III international multicenter, randomized controlled, two-arm, assessor-blinded trial

Raj, Rahul; Tommiska, Pihla; Kivisaari, Riku; Korja, Miikka; Luostarinen, Teemu; Virta, Jyri J; Taimela, Simo; Järvinen, Teppo LN Niemelä, Mika; Koivisto, Timo; Leinonen, Ville; Saemundsson, Bjartur; Fletcher-Sandersjöö, Alexander; Korhonen, Tommi; Tetri, Sami; Rauhala, Minna; Laukka, Dan; Czuba, Tomasz; Bartek, Jiri; Danner, Nils; Knuutinen, Oula; Luoto, Teemu; Posti, Jussi P; Satopää, Jarno, 2025, Trials, 26, 1, 515. A1 Journal article (refereed), original research

Segment Anything for Dendrites from Electron Microscopy

Zhuo, Zewen; Belevich, Ilya; Leinonen, Ville; Jokitalo, Eija; Malm, Tarja; Sierra, Alejandra; Tohka, Jussi, 2025, The Sixth IEEE International Image Processing, Applications and Systems Conference (IPAS'6) - Conference Proceedings, 1-6. A4 Conference proceedings

Single Cell Transcriptomics of Paired CSF and Blood Immune Populations Reveals Unique Macrophage Population with Relevance to Alzheimer's Disease

Stevens, Beth; Marsh, Samuel E; Fulthorpe, Rebecca; Murphy, Sarah; Kamath, Tushar; Gazestani, Vahid; Lieb, David; Eisenhaure, Thomas; Sarsani, Vishal; Reyes, Miguel; Gobom, Johan; Clish, Clary; Zetterberg, Henrik; Leinonen, Ville; Macosko, Evan; Hacohen, Nir, 2025, Alzheimer's & dementia. Abstract

Smart Rings in Remote Monitoring at Home: Older Patients' Perceptions and Expectations

Azim Zadegan, Melika; Aromaa, Eeva; Montonen, Tero; Sahlström, Rosa; Eriksson, Päivi; Leinonen, Ville, 2025, Health expectations, 28, 5, 1-10. A1 Journal article (refereed), original research

The protective PLCγ2-P522R variant mitigates Alzheimer’s disease-associated pathologies by enhancing beneficial microglial functions

Takalo, Mari; Jeskanen, Heli; Rolova, Taisia; Kervinen, Inka; Hellén, Marianna; Heikkinen, Sami; Koivisto, Hennariikka; Jokivarsi, Kimmo; Müller, Stephan A.; Koivumäki, Esa-Mikko; Mäkinen, Petra; Juopperi, Sini-Pauliina; Willman, Roosa-Maria; Sinisalo, Rosa; Hoffmann, Dorit; Jäntti, Henna; Peitz, Michael; Fließbach, Klaus; Kuulasmaa, Teemu; Natunen, Teemu; Kemppainen, Susanna; Poutiainen, Pekka; Leinonen, Ville; Malm, Tarja; Martiskainen, Henna; Ramirez, Alfredo; Haapasalo, Annakaisa; Lichtentha, 2025, Journal of neuroinflammation, 22, 1, 64. A1 Journal article (refereed), original research

Well-being in pain questionnaire: A novel, reliable, and valid tool for assessment of the personal well-being in individuals with chronic low back pain

Mikkonen, Jani; Martela, Frank; Holopainen, Riikka; Ekström, Kristian; Goubert, Liesbet; Leinonen, Ville; Selander, Tuomas; Airaksinen, Olavi; Neblett, Randy, 2025, Scandinavian journal of pain, 25, 1, 20240067. A1 Journal article (refereed), original research

Ambulatory Care vs Overnight Hospitalization After Anterior Surgery for Cervical Radiculopathy

Lönnrot, Kimmo; Taimela, Simo; Satopää, Jarno; Saarenpää, Ilkka; Leinonen, Ville; Kivelev, Juri; Silvasti-Lundell, Marja; Förster, Johannes; Pitkänen, Mikko; Raj, Rahul; Kauppinen, Mikko; Westermarck, Riitta; Jahromi, Behnam Rezai; Koski-Palkén, Anniina; Seppälä, Matti; Kivipelto, Leena; Antinheimo, Jussi; Korja, Miikka; Czuba, Tomasz; Järvinen, Teppo L. N., 2024, JAMA network open, 7, 11, e2447459. A1 Journal article (refereed), original research

Burr-hole drainage with or without irrigation for chronic subdural haematoma (FINISH): a Finnish, nationwide, parallel-group, multicentre, randomised, controlled, non-inferiority trial

Raj, Rahul; Tommiska, Pihla; Koivisto, Timo; Leinonen, Ville; Danner, Nils; Posti, Jussi P; Laukka, Dan; Luoto, Teemu; Rauhala, Minna; Tetri, Sami; Korhonen, Tommi K; Satopää, Jarno; Kivisaari, Riku; Luostarinen, Teemu; Schwartz, Christoph; Czuba, Tomasz; Taimela, Simo; Lönnrot, Kimmo; Järvinen, Teppo L N; on behalf of the Finnish study of intraoperative irrigation versus drain alone after evacuation of CSDH (FINISH) study group, 2024, The Lancet, 403, 10446, 2798-2806. A1 Journal article (refereed), original research

Considering the Potential Use of Oura Ring for Remote Monitoring at Home: The Perspective of Ageing Neurological Patients

Azim Zadegan, Melika; Sahlström, Rosa; Aromaa, Eeva; Montonen, Tero; Eriksson, Päivi; Leinonen, Ville, 2024, Communications in computer and information science. Abstract

Deep learning assisted quantitative analysis of Aβ and microglia in patients with idiopathic normal pressure hydrocephalus in relation to cognitive outcome

Luikku, Antti J; Nerg, Ossi; Koivisto, Anne M; Hanninen, Tuomo; Junkkari, Antti; Kemppainen, Susanna; Juopperi, Sini-Pauliina; Sinisalo, Rosa; Pesola, Alli; Soininen, Hilkka; Hiltunen, Mikko; Leinonen, Ville; Rauramaa, Tuomas; Martiskainen, Henna, 2024, Journal of neuropathology and experimental neurology, 83, 11, 967-978. A1 Journal article (refereed), original research

Dimensionality, reliability, and validity of the Finnish version of the pain catastrophizing scale in chronic low back pain

Mikkonen, Jani; Leinonen, Ville; Lähdeoja, Tuomas; Holopainen, Riikka; Ekström, Kristian; Koho, Petteri; Airaksinen, Olavi; Luciano, Juan V; Navarrete, Jaime; Neblett, Randy, 2024, Scandinavian journal of pain, 24, 1, 20240034. A1 Journal article (refereed), original research

Exploring the Association Between Visual Field Testing and CERAD Neuropsychological Battery in Idiopathic Normal Pressure Hydrocephalus Patients

Kemiläinen, Benjam; Tiainen, Sonja; Rauramaa, Tuomas; Luikku, Antti J; Herukka, Sanna-Kaisa; Koivisto, Anne; Hiltunen, Mikko; Verdooner, Steven; Johnson, Ken; Chambers, Mieko; Kaarniranta, Kai; Leinonen, Ville, 2024, Journal of Alzheimer's disease, 100, 1, 247-260. A1 Journal article (refereed), original research

Gut Microbiome Changes in Patients With Idiopathic Normal Pressure Hydrocephalus

Brandt, Emilia; Koivisto, Anne; Pereira, Pedro; Mustanoja, Ella; Auvinen, Petri; Saari, Toni; Lehtola, Juha-Matti; Hannonen, Sanna; Rusanen, Minna; Leinonen, Ville; Scheperjans, Filip; Kärkkäinen, Virve, 2024, Alzheimer disease and associated disorders, 38, 2, 133-139. A1 Journal article (refereed), original research

Human iPSC-derived pericyte-like cells carrying APP Swedish mutation overproduce beta-amyloid and induce cerebral amyloid angiopathy-like changes

Wu, Ying-Chieh; Lehtonen, Šárka; Trontti, Kalevi; Kauppinen, Riitta; Kettunen, Pinja; Leinonen, Ville; Laakso, Markku; Kuusisto, Johanna; Hiltunen, Mikko; Hovatta, Iiris; Freude, Kristine; Dhungana, Hiramani; Koistinaho, Jari; Rolova, Taisia, 2024, Fluids and barriers of the cns, 21, 1, 78. A1 Journal article (refereed), original research

Identical movement control exercises with and without synchronized breathing for chronic non-specific low back pain:A randomized pilot trial

Mikkonen, Jani; Luomajoki, Hannu; Airaksinen, Olavi; Goubert, Liesbet; Pratscher, Steven; Leinonen, Ville, 2024, Journal of back and musculoskeletal rehabilitation, 37, 6, 1561-1571. A1 Journal article (refereed), original research

Optimizing Feature Selection for Unbalanced Metabolomics Data with A Background Factor: A Comparative Study in Parkinson's Disease

Zhang, Yinjia; Hämäläinen, Wilhelmiina; Reinikka, Paavo; Herukka, Sanna Kaisa; Leinonen, Ville; Lehtonen, Marko; Lehtonen, Šárka, 2024, Cannataro, Mario; Zheng, Huiru (Jane); Gao, Lin; Cheng, Jianlin (Jack); de Miranda, João Luís; Zumpano, Ester; Hu, Xiaohua; Cho, Young-Rae; Park, Taesung, Proceedings: 2024 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2024, 5884-5891. A4 Conference proceedings

Outcome and complications of operatively treated subaxial cervical spine injuries: A population-based retrospective cohort study

Alve, Joel; Huttunen, Jukka; Leinonen, Ville; Jyrkkänen, Henna-Kaisa; Danner, Nils, 2024, World neurosurgery X, 22, 100283. A1 Journal article (refereed), original research

Risk Variants Associated With Normal Pressure Hydrocephalus: Genome-Wide Association Study in the FinnGen Cohort

Räsänen, Joel; Heikkinen, Sami; Mäklin, Kiira; Lipponen, Anssi; Kuulasmaa, Teemu; Mehtonen, Juha; Korhonen, Ville E; Junkkari, Antti; Grenier-Boley, Benjamin; Bellenguez, Celine; Oinas, Minna; Avellan, Cecilia; Frantzén, Janek; Kotkansalo, Anna; Rinne, Jaakko; Ronkainen, Antti; Kauppinen, Mikko; von und zu Fraunberg, Mikael; Lönnrot, Kimmo; Satopää, Jarno; Perola, Markus; Koivisto, Anne M; Julkunen, Valtteri; Portaankorva, Anne M; Mannermaa, Arto; Soininen, Hilkka; Helisalmi, Seppo; Jääskeläinen, 2024, Neurology, 103, 5, e209694. A1 Journal article (refereed), original research

Tear fluid reflects the altered protein expressions of Alzheimer's disease patients in proteins involved in protein repair and clearance system or the regulation of cytoskeleton

Kärkkäinen, V; Hannonen, S; Rusanen M; Lehtola, JM; Saari, T; Uusitalo, H; Leinonen, V; Thiede, B; Kaarniranta, K; Koivisto, AM; Utheim, T, 2024, Journal of Alzheimer's disease, 108, 1 Suppl, S42 - S49. A1 Journal article (refereed), original research

Utility of cortical tissue analysis in normal pressure hydrocephalus

Greenberg, Ana B. W.; Mekbib, Kedous Y.; Mehta, Neel H.; Kiziltug, Emre; Duy, Phan Q.; Smith, Hannah R.; Junkkari, Antti; Leinonen, Ville; Hyman, Bradley T.; Chan, Diane; Curry Jr, William T.; Arnold, Steven E.; Barker II, Frederick G.; Frosch, Matthew P.; Kahle, Kristopher T., 2024, Cerebral cortex, 34, 2, bhae001. A1 Journal article (refereed), original research

Ventriculoperitoneal shunt patients and glaucoma: a cohort analysis of the NPH registry

Kemiläinen, Benjam; Kaarniranta, Kai; Leinonen, Ville, 2024, Fluids and barriers of the cns, 21, 1, 54. A1 Journal article (refereed), original research

Cerebrospinal Fluid Diagnostics of Alzheimer's Disease in Patients with Idiopathic Normal Pressure Hydrocephalus

Vanninen, Aleksi; Lukkarinen, Heikki; Kokkola, Tarja; Koivisto, Anne M.; Kokki, Merja; Musialowicz, Tadeusz; Hiltunen, Mikko; Zetterberg, Henrik; Leinonen, Ville; Herukka, Sanna Kaisa; Rauramaa, Tuomas, 2023, Journal of Alzheimer's disease, 94, 2, 727-736. A1 Journal article (refereed), original research

Concordance of Alzheimer’s Disease-Related Biomarkers Between Intraventricular and Lumbar Cerebrospinal Fluid in Idiopathic Normal Pressure Hydrocephalus

Lukkarinen, Heikki; Vanninen, Aleksi; Tesseur, Ina; Pemberton, Darrel; Van Der Ark, Peter; Kokkola, Tarja; Herukka, Sanna-Kaisa; Rauramaa, Tuomas; Hiltunen, Mikko; Blennow, Kaj; Zetterberg, Henrik; Leinonen, Ville, 2023, Journal of Alzheimer's disease, 91, 1, 305-319. A1 Journal article (refereed), original research

Early Alzheimer's disease pathology in human cortex involves transient cell states

Gazestani, Vahid; Kamath, Tushar; Nadaf, Naeem M; Dougalis, Antonios; Burris, SJ; Rooney, Brendan; Junkkari, Antti; Vanderburg, Charles; Pelkonen, Anssi; Gomez-Budia, Mireia; Välimäki, Nelli Noora; Rauramaa, Tuomas; Therrien, Martine; Koivisto, Anne M; Tegtmeyer, Matthew; Herukka, Sanna Kaisa; Abdulraouf, Abdulraouf; Marsh, Samuel E; Hiltunen, Mikko; Nehme, Ralda; Malm, Tarja; Stevens, Beth; Leinonen, Ville; Macosko, Evan Z, 2023, Cell, 186, 20, 4438-4453.e23. A1 Journal article (refereed), original research

Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro

Dolan, Michael-John; Therrien, Martine; Jereb, Saša; Kamath, Tushar; Gazestani, Vahid; Atkeson, Trevor; Marsh, Samuel E.; Goeva, Aleksandrina; Lojek, Neal M.; Murphy, Sarah; White, Cassandra M.; Joung, Julia; Liu, Bingxu; Limone, Francesco; Eggan, Kevin; Hacohen, Nir; Bernstein, Bradley E.; Glass, Christopher K.; Leinonen, Ville; Blurton-Jones, Mathew; Zhang, Feng; Epstein, Charles B.; Macosko, Evan Z.; Stevens, Beth, 2023, Nature immunology, 24, 8, 1382-1390. A1 Journal article (refereed), original research

Normaalipaineisen hydrokefaluksen arvoitus

Leinonen, Ville; Hiltunen, Mikko, 2023, Duodecim, 139, 5, 340-342. D1 Article in a trade journal

Novel cerebrospinal fluid biomarkers correlating with shunt responsiveness in patients with idiopathic normal pressure hydrocephalus

Weiner, Sophia; Junkkari, Antti; Sauer, Mathias; Luikku, Antti; Rauramaa, Tuomas; Kokkola, Tarja; Herukka, Sanna-Kaisa; Blennow, Kaj; Zetterberg, Henrik; Leinonen, Ville; Gobom, Johan, 2023, Fluids and barriers of the cns, 20, 1, 40. A1 Journal article (refereed), original research

Operative Treatment of Tarlov Cysts - Outcomes and Predictors of Improvement after Surgery: A Series of 97 Consecutive Patients and a Systematic Review of Literature

Abdi, Delshad; Huttunen, Jukka; Leinonen, Ville; Savolainen, Sakari; Danner, Nils, 2023, Global spine journal, [Epub ahead of print 9 Dec 2023], 1-8. A1 Journal article (refereed), original research

Potent dual MAGL/FAAH inhibitor AKU-005 engages endocannabinoids to diminish meningeal nociception implicated in migraine pain

Della Pietra, Adriana; Krivoshein, Georgii; Ivanov, Konstantin; Giniatullina, Raisa; Jyrkkänen, Henna-Kaisa; Leinonen, Ville; Lehtonen, Marko; van den Maagdenberg, Arn MJM; Savinainen, Juha; Giniatullin, Rashid, 2023, Journal of headache and pain, 24, 1, 38. A1 Journal article (refereed), original research

Protective Alzheimer's disease-associated APP A673T variant predominantly decreases sAPPβ levels in cerebrospinal fluid and 2D/3D cell culture models

Wittrahm, Rebekka; Takalo, Mari; Kuulasmaa, Teemu; Mäkinen, Petra M; Mäkinen, Petri; Končarević, Saša; Fartzdinov, Vadim; Selzer, Stefan; Kokkola, Tarja; Antikainen, Leila; Martiskainen, Henna; Kemppainen, Susanna; Marttinen, Mikael; Jeskanen, Heli; Rostalski, Hannah; Rahunen, Eija; Kivipelto, Miia; Ngandu, Tiia; Natunen, Teemu; Lambert, Jean-Charles; Tanzi, Rudolph E; Kim, Doo Yeon; Rauramaa, Tuomas; Herukka, Sanna-Kaisa; Soininen, Hilkka; Laakso, Markku; Pike, Ian; Leinonen, Ville; Haapasalo,, 2023, Neurobiology of disease, 182, 106140. A1 Journal article (refereed), original research

Protocol of identical exercise programs with and without specific breathing techniques for the treatment of chronic non-specific low back pain: randomized feasibility trial with two-month follow-up

Mikkonen, Jani; Luomajoki, Hannu; Airaksinen, Olavi; Goubert, Liesbet; Leinonen, Ville, 2023, Bmc musculoskeletal disorders, 24, 1, 354. A1 Journal article (refereed), original research

Reduced binding of apoE4 to complement factor H promotes amyloid‐β oligomerization and neuroinflammation

Chernyaeva, Larisa; Ratti, Giorgio; Teirilä, Laura; Fudo, Satoshi; Rankka, Uni; Pelkonen, Anssi; Korhonen, Paula; Leskinen, Katarzyna; Keskitalo, Salla; Salokas, Kari; Gkolfinopoulou, Christina; Crompton, Katrina E; Javanainen, Matti; Happonen, Lotta; Varjosalo, Markku; Malm, Tarja; Leinonen, Ville; Chroni, Angeliki; Saavalainen, Päivi; Meri, Seppo; Kajander, Tommi; Wollman, Adam JM; Nissilä, Eija; Haapasalo, Karita, 2023, Embo reports, 24, 7, e56467. A1 Journal article (refereed), original research

Serum Cathepsin S Levels Do Not Show Alterations in Different Clinical, Neuropathological, or Genetic Subtypes of Frontotemporal Dementia Patients nor in Comparison to Healthy Control Individuals

Heikkinen, Sami; Huber, Nadine; Katisko, Kasper; Kokkola, Tarja; Hartikainen, Päivi; Krüger, Johanna; Leinonen, Ville; Korhonen, Ville E; Herukka, Sanna-Kaisa; Remes, Anne M; Borroni, Barbara; Alberici, Antonella; Libri, Ilenia; Solje, Eino; Haapasalo, Annakaisa, 2023, Journal of Alzheimer's disease, 93, 2, 395-401. A1 Journal article (refereed), original research

To what degree patient-reported symptoms of central sensitization, kinesiophobia, disability, sleep, and life quality associated with 24-h heart rate variability and actigraphy measurements?

Mikkonen, Jani; Kupari; Saana; Tarvainen, Mika; Neblett, Randy; Airaksinen, Olavi; Luomajoki, Hannu; Leinonen, Ville, 2023, Pain practice, 24, 4, 609-619. A1 Journal article (refereed), original research

Cerebrospinal fluid biomarkers that reflect clinical symptoms in idiopathic normal pressure hydrocephalus patients

Lukkarinen, Heikki; Jeppsson, Anna; Wikkelsö, Carsten; Blennow, Kaj; Zetterberg, Henrik; Constantinescu, Radu; Remes, Anne M.; Herukka, Sanna-Kaisa; Hiltunen, Mikko; Rauramaa, Tuomas; Nägga, Katarina; Leinonen, Ville; Tullberg, Mats, 2022, Fluids and barriers of the cns, 19, 1, 11. A1 Journal article (refereed), original research

Computer-based Eye-tracking Analysis of King-Devick Test Differentiates Persons With Idiopathic Normal Pressure Hydrocephalus From Cognitively Unimpaired

Lehtola, Juha-Matti; Kärkkäinen, Virve; Andberg, Sami; Hannonen, Sanna; Rusanen, Minna; Saari, Toni; Korhonen, Ville; Hokkanen, Laura; Hallikainen, Merja; Hänninen, Tuomo; Kaarniranta, Kai; Bednarik, Roman; Leinonen, Ville; Koivisto, Anne M, 2022, Alzheimer disease and associated disorders, 36, 4, 340-346. A1 Journal article (refereed), original research

Editorial: Toward a better understanding of the pathophysiology and clinical management of idiopathic normal pressure hydrocephalus

Karagiozov, Kostadin L.; Leinonen, Ville; Miyajima, Masakazu; Nakajima, Madoka, 2022, Frontiers in neurology, 13, 1013720. B1 Non-refereed journal articles

Genome-wide meta-analysis for Alzheimer’s disease cerebrospinal fluid biomarkers

Jansen, Iris E.; van der Lee, Sven J.; Gomez-Fonseca, Duber; de Rojas, Itziar; Dalmasso, Maria Carolina; Grenier-Boley, Benjamin; Zettergren, Anna; Mishra, Aniket; Ali, Muhammad; Andrade, Victor; Bellenguez, Céline; Kleineidam, Luca; Küçükali, Fahri; Sung, Yun Ju; Tesí, Niccolo; Vromen, Ellen M.; Wightman, Douglas P.; Alcolea, Daniel; Alegret, Montserrat; Alvarez, Ignacio; Amouyel, Philippe; Athanasiu, Lavinia; Bahrami, Shahram; Bailly, Henri; Belbin, Olivia; Bergh, Sverre; Bertram, Lars; Biesse, 2022, Acta neuropathologica, 144, 5, 821-842. A1 Journal article (refereed), original research

In vivo assessment of Lewy body and beta-amyloid copathologies in idiopathic normal pressure hydrocephalus: prevalence and associations with clinical features and surgery outcome

Giannini, Giulia; Baiardi, Simone; Dellavalle, Sofia; Zenesini, Corrado; Cevoli, Sabina; Danner, Nils; Jyrkkänen, Henna-Kaisa; Rossi, Marcello; Polischi, Barbara; Quadalti, Corinne; Stefanini, Camilla; Cortelli, Pietro; Milletti, David; Herukka, Sanna-Kaisa; Palandri, Giorgio; Leinonen, Ville; Parchi, Piero, 2022, Fluids and barriers of the cns, 19, 1, 71. A1 Journal article (refereed), original research

Incidence and risk factors of spinal cord stimulation for persistent or recurrent pain after lumbar spine surgery: a population-based study

Huttunen, Jukka; Fraunberg, Mikael von und zu; Ikäheimo, Tiina-Mari; Jyrkkänen, Henna-Kaisa; Nissen, Mette; Leinonen, Ville; Salmenkivi, Jyrki; Malmivaara, Antti; Sirola, Joonas; Sund, Reijo, 2022, Acta neurochirurgica, 164, 10, 2645-2653. A1 Journal article (refereed), original research

Kaularangan luisen juuriaukkoahtauman kirurginen hoito

Kotkansalo, Anna; Leinonen, Ville; Korhonen, Katariina; Rinne, Jaakko; Malmivaara, Antti, 2022, Duodecim, 138, 9, 769-777. A2 Review article, Literature review, Systematic review

Neuropathological findings in possible normal pressure hydrocephalus: A post-mortem study of 29 cases with lifelines

Hänninen, JJ; Nakajima, M; Vanninen, A; Hytönen, S; Rummukainen, J; Koivisto, AM; Jääskeläinen, JE; Soininen, H; Sutela, A; Vanninen, R; Hiltunen, M; Leinonen, V; Rauramaa, T, 2022, Free neuropathology, 3, 2, 1-17. A1 Journal article (refereed), original research

Postural sway does not differentiate individuals with chronic low back pain, single and multisite chronic musculoskeletal pain, or pain-free controls: a cross-sectional study of 229 subjects

Mikkonen, Jani; Leinonen, Ville; Kaski, Diego; Hartvigsen, Jan; Luomajoki, Hannu; Selander, Tuomas; Airaksinen, Olavi, 2022, Spine journal, 22, 9, 1523-1534. A1 Journal article (refereed), original research

Serum total TDP-43 levels are decreased in frontotemporal dementia patients with C9orf72 repeat expansion or concomitant motoneuron disease phenotype

Katisko, Kasper; Huber, Nadine; Kokkola, Tarja; Hartikainen, Päivi; Krüger, Johanna; Heikkinen, Anna-Leena; Paananen, Veera; Leinonen, Ville; Korhonen, Ville E.; Helisalmi, Seppo; Herukka, Sanna-Kaisa; Cantoni, Valentina; Gadola, Yasmine; Archetti, Silvana; Remes, Anne M.; Haapasalo, Annakaisa; Borroni, Barbara; Solje, Eino, 2022, Alzheimer's research and therapy, 14, 1, 151. A1 Journal article (refereed), original research

Shortening of Saccades as a Possible Easy-to-Use Biomarker to Detect Risk of Alzheimer’s Disease

Hannonen, Sanna; Andberg, Sami; Kärkkäinen, Virve; Rusanen, Minna; Lehtola, Juha-Matti; Saari, Toni; Korhonen, Ville; Hokkanen, Laura; Hallikainen, Merja; Hänninen, Tuomo; Leinonen, Ville; Kaarniranta, Kai; Bednarik, Roman; Koivisto, Anne M., 2022, Journal of Alzheimer's disease, 88, 2, 609-618. A1 Journal article (refereed), original research

The effect of antithrombotic therapy on the recurrence and outcome of chronic subdural hematoma after burr-hole craniostomy in a population-based cohort

Kerttula, Santtu; Huttunen, Jukka; Leinonen, Ville; Kämäräinen, Olli Pekka; Danner, Nils, 2022, Acta neurochirurgica, 164, 10, 2699-2708. A1 Journal article (refereed), original research

The effect of shunt surgery on corticospinal excitability in idiopathic normal pressure hydrocephalus: a transcranial magnetic stimulation study

Sirkka, Jani; Säisänen, Laura; Julkunen, Petro; Könönen, Mervi; Kallioniemi, Elisa; Leinonen, Ville; Danner, Nils, 2022, Fluids and barriers of the cns, 19, 1, 89. A1 Journal article (refereed), original research

5-Year health-related quality of life outcome in patients with idiopathic normal pressure hydrocephalus

Junkkari, A; Sintonen, H; Danner, N; Jyrkkänen, HK; Rauramaa, T; Luikku, AJ; Koivisto, AM; Roine, RP; Viinamäki, H; Soininen, H; Jääskeläinen, JE; Leinonen, V, 2021, Journal of neurology, 268, 9, 3283-3293. A1 Journal article (refereed), original research

A Novel Genetic Marker for the C9orf72 Repeat Expansion in the Finnish Population

Rostalski, H; Korhonen, V; Kuulasmaa, T; Solje, E; Krüger, J; Gen, F; Kaivola, K; Eide, PK; Lambert, JC; Julkunen, V; Tienari, PJ; Remes, AM; Leinonen, V; Hiltunen, M; Haapasalo, A, 2021, Journal of Alzheimer's disease, 83, 3, 1325-1332. A1 Journal article (refereed), original research

Alzheimerin taudin uudet riskigeenit - keskiössä mikrogliasolut

Martiskainen, Henna; Takalo, Mari; Konttinen, Henna; Malm, Tarja; Haapasalo, Annakaisa; Leinonen, Ville; Hiltunen, Mikko, 2021, Duodecim, 137, 13, 1375- 1382. A2 Review article, Literature review, Systematic review

Cerebrospinal fluid dynamics in idiopathic intracranial hypertension: a literature review and validation of contemporary findings

Kaipainen, Aku L; Martoma, Erik; Puustinen, Tero; Tervonen, Joona; Jyrkkänen, Henna-Kaisa; Paterno, Jussi J; Kotkansalo, Anna; Rantala, Susanna; Vanhanen, Ulla; Leinonen, Ville; Lehto, Soili M; Iso-Mustajärvi, Matti; Elomaa, Antti-Pekka; Qvarlander, Sara; Huuskonen, Terhi J, 2021, Acta neurochirurgica, 163, 12, 3353-3368. A2 Review article, Literature review, Systematic review

Cross-Cultural Adaptation, Reliability, and Psychophysical Validation of the Pain and Sleep Questionnaire Three-Item Index in Finnish

Mikkonen, Jani; Leinonen, Ville; Luomajoki, Hannu; Kaski, Diego; Kupari, Saana; Tarvainen, Mika; Selander, Tuomas; Airaksinen, Olavi, 2021, Journal of clinical medicine, 10, 21, 4887. A1 Journal article (refereed), original research

Cross-cultural adaptation and validation of the Finnish version of the central sensitization inventory and its relationship with dizziness and postural control

Mikkonen, Jani; Luomajoki, Hannu; Airaksinen, Olavi; Neblett, Randy; Selander, Tuomas; Leinonen, Ville, 2021, Bmc neurology, 21, 1, 141. A1 Journal article (refereed), original research

Elevated CSF LRG and Decreased Alzheimer's Disease Biomarkers in Idiopathic Normal Pressure Hydrocephalus

Vanninen, Aleksi; Nakajima, Madoka; Miyajima, Masakazu; Rauramaa, Tuomas; Kokki, Merja; Musialowicz, Tadeusz; Mäkinen, Petra M; Herukka, Sanna-Kaisa; Koivisto, Anne M; Jääskeläinen, Juha E; Hiltunen, Mikko; Leinonen, Ville, 2021, Journal of clinical medicine, 10, 5, 1105. A1 Journal article (refereed), original research

Ex Vivo Porcine Models Are Valid for Testing and Training Microsurgical Lumbar Decompression Techniques

Säteri, Tuomas; Nurro, Jussi; Hätinen, Olli-Pekka; Hakulinen, Mikko; Leinonen, Ville; Elomaa, Antti-Pekka, 2021, World neurosurgery, 155, e64-e74. A1 Journal article (refereed), original research

FTLD Patient-Derived Fibroblasts Show Defective Mitochondrial Function and Accumulation of p62

Leskelä, S; Hoffmann, D; Rostalski, H; Huber, N; Wittrahm, R; Hartikainen, P; Korhonen, V; Leinonen, V; Hiltunen, M; Solje, E; Remes, AM; Haapasalo, A, 2021, Molecular neurobiology, 58, 11, 5438-5458. A1 Journal article (refereed), original research

Functional Characterization of Human Pluripotent Stem Cell-Derived Models of the Brain with Microelectrode Arrays

Pelkonen, Anssi; Pistono, Cristiana; Klecki, Pamela; Gómez-Budia, Mireia; Dougalis, Antonios; Konttinen, Henna; Stanová, Iveta; Fagerlund, Ilkka; Leinonen, Ville; Korhonen, Paula; Malm, Tarja, 2021, Cells, 2022; 11, 1, 106. A2 Review article, Literature review, Systematic review

Gabapentinoids Associated With Lower Explantation Rate in 203 Patients With Spinal Cord Stimulation for Failed Back Surgery Syndrome

Nissen, Mette; Ikäheimo, Tiina-Mari; Huttunen, Jukka; Leinonen, Ville; Jyrkkänen, Henna-Kaisa; von und zu Fraunberg, Mikael, 2021, Neurosurgery, 89, 4, 626-634. A1 Journal article (refereed), original research

MECP2 Increases the Pro-Inflammatory Response of Microglial Cells and Phosphorylation at Serine 423 Regulates Neuronal Gene Expression upon Neuroinflammation

Wittrahm, Rebekka; Takalo, Mari; Marttinen, Mikael; Kuulasmaa, Teemu; Mäkinen, Petra; Kemppainen, Susanna; Martiskainen, Henna; Rauramaa, Tuomas; Pike, Ian; Leinonen, Ville; Natunen, Teemu; Haapasalo, Annakaisa; Hiltunen, Mikko, 2021, Cells, 10, 4, 860. A1 Journal article (refereed), original research

Plasma miR-9-3p and miR-136-3p as Potential Novel Diagnostic Biomarkers for Experimental and Human Mild Traumatic Brain Injury

Das Gupta, Shalini; Ciszek, Robert; Heiskanen, Mette; Lapinlampi, Niina; Kukkonen, Janne; Leinonen, Ville; Puhakka, Noora; Pitkänen, Asla, 2021, International journal of molecular sciences, 22, 4, 1563. A1 Journal article (refereed), original research

Preoperative measurements on MRI in Chiari 1 patients fail to predict outcome after decompressive surgery

Jussila, Miro-Pekka; Nissilä, Juho; Vakkuri, Minna; Olsén, Päivi; Niinimäki, Jaakko; Leinonen, Ville; Serlo, Willy; Salokorpi, Niina; Suo-Palosaari, Maria, 2021, Acta neurochirurgica, [Epub ahead of print 11 May 2021], 1-10. A1 Journal article (refereed), original research

S327 phosphorylation of the presynaptic protein SEPTIN5 increases in the early stages of neurofibrillary pathology and alters the functionality of SEPTIN5

Ferreira, Catarina B.; Marttinen, Mikael; Coelho, Joana E.; Paldanius, Kaisa M.A.; Takalo, Mari; Mäkinen, Petra; Leppänen, Luukas; Miranda-Lourenço, Catarina; Fonseca-Gomes, João; Tanqueiro, Sara R.; Vaz, Sandra H.; Belo, Rita F.; Sebastião, Ana Maria; Leinonen, Ville; Soininen, Hilkka; Pike, Ian; Haapasalo, Annakaisa; Lopes, Luísa V.; de Mendonça, Alexandre; Diógenes, Maria José; Hiltunen, Mikko, 2021, Neurobiology of disease, 2022; 163, 105603. A1 Journal article (refereed), original research

Shunt performance in 349 patients with hydrocephalus after aneurysmal subarachnoid hemorrhage

Tervonen, Joona; Adams, Hadie; Lindgren, Antti; Elomaa, Antti-Pekka; Kämäräinen, Olli-Pekka; Kärkkäinen, Virve; von und zu Fraunberg, Mikael; Huttunen, Jukka; Koivisto, Timo; Jääskeläinen, Juha E.; Leinonen, Ville; Huuskonen, Terhi J., 2021, Acta neurochirurgica, 163, 10, 2703-2714. A1 Journal article (refereed), original research

Surgically treated C1 fractures: a population-based study

Ylönen, Henri; Danner, Nils; Jyrkkänen, Henna-Kaisa; Kämäräinen, Olli-Pekka; Leinonen, Ville; Huttunen, Jukka, 2021, World neurosurgery, 154, e333-e342. A1 Journal article (refereed), original research

The CERAD Neuropsychological Battery in Patients with Idiopathic Normal Pressure Hydrocephalus Compared with Normal Population and Patients with Mild Alzheimer's Disease

Nerg, Ossi; Junkkari, Antti; Hallikainen, Ilona; Rauramaa, Tuomas; Luikku, Antti; Hiltunen, Mikko; Jääskeläinen, Juha E.; Leinonen, Ville; Hänninen, Tuomo; Koivisto, Anne;, 2021, Journal of Alzheimer's disease, 81, 3, 1117-1130. A1 Journal article (refereed), original research

Time Trends of Cerebrospinal Fluid Biomarkers of Neurodegeneration in Idiopathic Normal Pressure Hydrocephalus

Lukkarinen, Heikki; Tesseur, Ina; Pemberton, Darrel; Van Der Ark, Peter; Timmers, Maarten; Slemmon, Randy; Janssens, Luc; Streffer, Johannes; Van Nueten, Luc; Bottelbergs, Astrid; Rauramaa, Tuomas; Koivisto, Anne M.; Herukka, Sanna-Kaisa; Korhonen, Ville E.; Junkkari, Antti; Hiltunen, Mikko; Engelborghs, Sebastiaan; Blennowk, Kaj; Zetterbergk, Henrik; Kolb, Hartmuth C.; Leinonen, Ville, 2021, Journal of Alzheimer's disease, 80, 4, 1629-1642. A1 Journal article (refereed), original research

Upper limb dysfunction and activities in daily living in idiopathic normal pressure hydrocephalus

Sirkka, Jani; Parviainen, Marita; Jyrkkänen, Henna-Kaisa; Koivisto, Anne M.; Säisänen, Laura; Rauramaa, Tuomas; Leinonen, Ville; Danner, Nils, 2021, Acta neurochirurgica, 163, 10, 2675-2683. A1 Journal article (refereed), original research

iNPH - the mystery resolving

Leinonen, Ville; Kuulasmaa, Teemu; Hiltunen, Mikko, 2021, Embo molecular medicine, 13, 3, e13720. B1 Non-refereed journal articles

Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-ß from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy

Carare, RO; Aldea, R; Agarwal, N; Bacskai, BJ; Bechman, I; Boche, D; Bu, G; Bulters, D; Clemens, A; Counts, SE; de Leon, M; Eide, PK; Fossati, S; Greenberg, SM; Hamel, E; Hawkes, CA; Koronyo-Hamaoui, M; Hainsworth, AH; Holtzman, D; Ihara, M; et al [incl. Kanninen, K; Leinonen, V; Malm, T], 2020, Alzheimer's & dementia : diagnosis, assessment & disease monitoring, 21, 1, e12053. A1 Journal article (refereed), original research

Corticospinal Excitability in Idiopathic Normal Pressure Hydrocephalus: A Transcranial Magnetic Stimulation Study

Sirkka, J; Säisänen, L; Julkunen, P; Könönen, M; Kallioniemi, E; Leinonen, V; Danner, N, 2020, Fluids and barriers of the cns, 17, 1, 6. A1 Journal article (refereed), original research

Diabetes is associated with familial idiopathic normal pressure hydrocephalus: a case-control comparison with family members

Räsänen, Joel; Huovinen, Joel; Korhonen, Ville E; Junkkari, Antti; Kastinen, Sami; Komulainen, Simo; Oinas, Minna; Avellan, Cecilia; Frantzen, Janek; Rinne, Jaakko; Ronkainen, Antti; Kauppinen, Mikko; Lönnrot, Kimmo; Perola, Markus; Koivisto, Anne M; Remes, Anne M; Soininen, Hilkka; Hiltunen, Mikko; Helisalmi, Seppo; Kurki, Mitja I [et al. incl. Jääskeläinen, Juha E: Leinonen, Ville], 2020, Fluids and barriers of the cns, 17, 57. A1 Journal article (refereed), original research

Diabetic phenotype in mouse and humans reduces the number of microglia around ß-amyloid plaques

Natunen, Teemu; Martiskainen, Henna; Marttinen, Mikael; Gabbouj, Sami; Koivisto, Hennariikka; Kemppainen, Susanna; Kaipainen, Satu; Takalo, Mari; Svobodová, Helena; Leppänen, Luukas; Kemiläinen, Benjam; Ryhänen, Simo; Kuulasmaa, Teemu: Rahunen, Eija: Juutinen, Sisko; Mäkinen, Petra; Miettinen, Pasi; Rauramaa, Tuomas; Pihlajamäki, Jussi; Haapasalo, Annakaisa; et al [incl. Leinonen, Ville; Tanila, Heikki; Hiltunen, Mikko], 2020, Molecular neurodegeneration, 15, 66. A1 Journal article (refereed), original research

Finnish Study of Intraoperative Irrigation Versus Drain Alone After Evacuation of Chronic Subdural Haematoma (FINISH): A Study Protocol for a Multicentre Randomised Controlled Trial

Tommiska, P; Raj, R; Schwartz, C; Kivisaari, R; Luostarinen, T; Satopää, J; Taimela, S; Järvinen, T; Ranstam, J; Frantzen, J; Posti, J; Luoto, TM; Leinonen, V; Tetri, S; Koivisto, T; Lönnrot, K, 2020, BMJ open, 10, 6, e038275. A1 Journal article (refereed), original research

Higher Preimplantation Opioid Doses Associated With Long-Term Spinal Cord Stimulation Failure in 211 Patients With Failed Back Surgery Syndrome

Nissen, Mette; Ikäheimo, Tiina-Mari; Huttunen, Jukka; Leinonen, Ville; Jyrkkänen, Henna-Kaisa; von Und Zu Fraunberg, Mikael, 2020, Neuromodulation, 2021; 24, 1, 102-111. A1 Journal article (refereed), original research

LifeTime and improving European healthcare through cell-based interceptive medicine

Rajewsky, Nikolaus; Almouzni, Geneviève; Gorski, Stanislaw A; Aerts, Stein; Amit, Ido; Bertero, Michela G; Bock, Christoph; Bredenoord, Annelien L; Cavalli, Giacomo; Chiocca, Susanna; Clevers, Hans; Strooper, Bart De; Eggert, Angelika; Ellenberg, Jan; Fernández, Xosé M; Figlerowicz, Marek; Gasser, Susan M; Hubner, Norbert; Kjems, Jørgen; Knoblich, Jürgen A et al. [incl. Pitkänen, Asla; Leinonen, Ville], 2020, Nature, 587, 377-386. A1 Journal article (refereed), original research

Occurrence, Risk Factors, and Time Trends for Late Reoperations due to Degenerative Cervical Spine Disease: A Finnish National Register Study of 19 377 Patients Operated on Between 1999 and 2015

Kotkansalo, Anna; Leinonen, Ville; Korajoki, Merja; Korhonen, Katariina; Rinne, Jaakko; Malmivaara, Antti, 2020, Neurosurgery, 2021; 88, 3, 558-573. A1 Journal article (refereed), original research

PTPR type Q in cerebrospinal fluid reflects ependymal cells dysfunction and is a potential biomarker for adult chronic hydrocephalus

Nakajima, Madoka; Rauramaa, Tuomas; Mäkinen, Petra M; Hiltunen, Mikko; Herukka, Sanna-Kaisa; Kokki, Merja; Musialowicz, Tadeusz; Jyrkkänen, Henna-Kaisa; Danner, Nils; Junkkari, Antti; Koivisto, Anne M; Jääskeläinen, Juha E; Miyajima, Masakazu; Ogino, Ikuko; Furuta, Akiko; Akiba, Chihiro; Kawamura, Kaito; Kamohara, Chihiro; Sugano, Hidenori; Tange, Yuichi; et al. [incl. Leinonen, Ville], 2020, European journal of neurology, 2021; 28, 2, 389-400. A1 Journal article (refereed), original research

Preoperative Predictors of Better Long-Term Functional Ability and Decreased Pain Following LSS Surgery: A Prospective Observational Study with a 10-year Follow-Up Period

Tuomainen, I; Pesonen, J; Rade, M; Pakarinen, M; Leinonen, V; Kröger, H; Airaksinen, O; Aalto, T, 2020, Spine, 45, 11, 776-783. A1 Journal article (refereed), original research

Presynaptic Vesicle Protein SEPTIN5 Regulates the Degradation of APP C-Terminal Fragments and the Levels of Aß

Marttinen, Mikael; Ferreira, Catarina B; Paldanius, Kaisa M A; Takalo, Mari; Natunen, Teemu; Mäkinen, Petra; Leppänen, Luukas; Leinonen, Ville; Tanigaki, Kenji; Kang, Gina; Hiroi, Noboru; Soininen, Hilkka; Rilla, Kirsi; Haapasalo, Annakaisa; Hiltunen, Mikko, 2020, Cells, 9, 11, 2482. A1 Journal article (refereed), original research

Unfolding the outcomes of surgical treatment of lumbar spinal stenosis-a prospective 5- and 10-year follow-up study

Tuomainen, I; Aalto, T; Pesonen, J; Rade, M; Pakarinen, M; Leinonen, V; Kröger, H; Airaksinen, O, 2020, European spine journal, 29, 9, 2231-2242. A1 Journal article (refereed), original research

Aivovammat

Luoto, Teemu; Leinonen, Ville; Bendel, Stepani; Koivisto, Timo; Jääskeläinen, Juha E, 2019, Leppäniemi, Ari; Kuokkanen, Hannu; Salminen, Pauliina, Kirurgia, 892-905. D2 Article in a professional book (incl. an introduction by the editor)

CSF biomarkers distinguish idiopathic normal pressure hydrocephalus from its mimics

Jeppsson, Anna; Wikkelsö, Carsten; Blennow, Kaj; Zetterberg, Henrik; Constantinescu, Radu; Remes, Anne M; Herukka, Sanna-Kaisa; Rauramaa, Tuomas; Nagga, Katarina; Leinonen, Ville; Tullberg, Mats, 2019, Journal of neurology neurosurgery and psychiatry, 90, 10, 1117-1123. A1 Journal article (refereed), original research

Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology: A Systematic Review and Meta-analysis

Bridel, C; van Wieringen, WN; Zetterberg, H; Tijms, BM; Teunissen, CE; Alvarez-Cermeño, JC; Andreasson, U; Axelsson, M; Bäckström, DC; Bartos, A; Bjerke, M; Blennow, K; Boxer, A; Brundin, L; Burman, J; Christensen, T; Fialová, L; Forsgren, L; Frederiksen, JL; Gisslén, M; et al.; and the NFL Group (incl. Leinonen, V), 2019, JAMA neurology, 76, 9, 1035-1048. A2 Review article, Literature review, Systematic review

Finnish Trial on Practices of Anterior Cervical Decompression and Fusion (FACADE): a protocol for a prospective randomised non-inferiority trial comparing outpatient versus inpatient care

Lönnrot, Kimmo; Taimela, Simo; Toivonen, Pirjo; Aronen, Pasi; Koski-Palken, Anniina; Frantzen, Janek; Leinonen, Ville; Silvasti-Lundell, Marja; Förster, Johannes; Jarvinen, Teppo, 2019, BMJ open, 9, 11, 1-8. A1 Journal article (refereed), original research

MIM-Deficient Mice Exhibit Anatomical Changes in Dendritic Spines, Cortex Volume and Brain Ventricles, and Functional Changes in Motor Coordination and Learning

Minkeviciene R, Hlushchenko, I; Virenque, A; Lahti, L; Khanal, P; Rauramaa, T; Koistinen, A; Leinonen, V; Noe, FM; Hotulainen, P, 2019, Frontiers in molecular neuroscience, 12, 276. A1 Journal article (refereed), original research

Normaalipaineisen hydrokefaluksen kliininen kuva, diagnostiset tutkimukset ja hoito

Leinonen, Ville; Junkkari, Antti; Rauramaa, Tuomas; Jääskeläinen, Juha E; Vanninen, Ritva; Savolainen, Sakari; Hiltunen, Mikko; Remes, Anne M; Koivisto, Anne M, 2019, Duodecim, 135, 3, 265-273. A2 Review article, Literature review, Systematic review

Predicting Development of Alzheimer's Disease in Patients with Shunted Idiopathic Normal Pressure Hydrocephalus

Luikku, AJ; Hall, A; Nerg, O; Koivisto, AM; Hiltunen, M; Helisalmi, S; Herukka, SK; Junkkari, A; Sutela, A; Kojoukhova, M; Korhonen, V; Mattila, J; Lötjönen, J; Rummukainen, J; Alafuzoff, I; Jääskeläinen, JE; Remes, AM; Solomon, A; Kivipelto, M; Soininen, H; et al. [Incl. Rauramaa, T; Leinonen, V], 2019, Journal of Alzheimer's disease, 71, 4, 1233-1243. A1 Journal article (refereed), original research

Prevalence of C9ORF72 Expansion in a Large Series of Patients with Idiopathic Normal-Pressure Hydrocephalus

Korhonen, VE; Remes, AM; Helisalmi, S; Rauramaa, T; Sutela, A; Vanninen, R; Suhonen, NM; Haapasalo, A; Hiltunen, M; Jääskeläinen, JE; Soininen, H; Koivisto, AM; Leinonen, V, 2019, Dementia and geriatric cognitive disorders, 47, 1-2, 91-103. A1 Journal article (refereed), original research

Psychiatric disorders are a common prognostic marker for worse outcome in patients with idiopathic intracranial hypertension

Puustinen, Tero; Tervonen, Joona; Avellan, Cecilia; Jyrkkänen, Henna-Kaisa; Paterno, Jussi J; Hartikainen, Päivi; Vanhanen, Ulla; Leinonen, Ville; Lehto, Soili M; Elomaa, Antti-Pekka; Huttunen, Terhi J, 2019, Clinical neurology and neurosurgery, 186, 105527. A1 Journal article (refereed), original research

Surgery for degenerative cervical spine disease in Finland, 1999-2015

Kotkansalo, A; Leinonen, V; Korajoki, M; Salmenkivi, J; Korhonen, K; Malmivaara, A, 2019, Acta neurochirurgica, 161, 10, 2147-2159. A1 Journal article (refereed), original research

Surgical techniques for degenerative cervical spine in Finland from 1999 to 2015

Kotkansalo, A; Malmivaara, A; Korajoki, M; Korhonen, K; Leinonen, V, 2019, Acta neurochirurgica, 161, 10, 2161-2173. A1 Journal article (refereed), original research

The Kuopio idiopathic normal pressure hydrocephalus protocol: initial outcome of 175 patients

Junkkari, A; Luikku, A J; Danner, N; Jyrkkänen, H K; Rauramaa, T; Korhonen, V E; Koivisto, A M; Nerg, O; Kojoukhova, M; Huttunen, T J; Jääskeläinen, J E; Leinonen, V, 2019, Fluids and barriers of the cns, 16, 21. A1 Journal article (refereed), original research

[11C]PIB PET Is Associated with the Brain Biopsy Amyloid-ß Load in Subjects Examined for Normal Pressure Hydrocephalus

Rinne, JO; Suotunen, T; Rummukainen, J; Herukka, SK; Nerg, O; Koivisto, AM; Rauramaa, T; Någren, K; Hiltunen, M; Alafuzoff, I; Rinne, J; Jääskeläinen, JE; Soininen, H; Leinonen, V, 2019, Journal of Alzheimer's disease, 67, 4, 1343-1351. A1 Journal article (refereed), original research

Aikuisten hydrokefalus ja sunttikomplikaatiot

Jääskeläinen, Juha E; Leinonen, Ville, 2018, Jousimaa, Jukkapekka; Alenius, Heidi; Atula, Sari; Berghem, Nora; Kattainen, Anna; Kunnamo, Ilkka; Pelttari, Hanna; Teikar, Martti, Lääkärin käsikirja [online]. D2 Article in a professional book (incl. an introduction by the editor)

Alterations in mitochondria-endoplasmic reticulum connectivity in human brain biopsies from idiopathic normal pressure hydrocephalus patients

Leal, NS; Dentoni, G; Schreiner, B; Kämäräinen, OP; Partanen, N; Herukka, SK; Koivisto, AM; Hiltunen, M; Rauramaa, T; Leinonen, V; Ankarcrona, M, 2018, Acta neuropathologica communications, 6, 102. A1 Journal article (refereed), original research

Copy number loss in SFMBT1 is common among Finnish and Norwegian patients with iNPH

Korhonen, VE; Helisalmi, S; Jokinen, A; Jokinen, I; Lehtola, JM; Oinas, M; Lönnrot, K; Avellan, C; Kotkansalo, A; Frantzen, J; Rinne, J; Ronkainen, A; Kauppinen, M; Junkkari, A; Hiltunen, M; Soininen, H; Kurki, M; Jääskeläinen, JE; Koivisto, AM; Sato, H; et al, 2018, Neurology : Genetics, 4, 6, e291. A1 Journal article (refereed), original research

Ensihoidosta neurotehohoitoon

Leinonen, Ville; Kurola, Jouni; Lång, Maarit; Niemelä, Mika; Jääskeläinen, Juha E, 2018, Leppäniemi, Ari; Kuokkanen, Hannu; Salminen, Pauliina, Kirurgia, 882-885. D2 Article in a professional book (incl. an introduction by the editor)

Incidence, comorbidities, and mortality in idiopathic normal pressure hydrocephalus

Pyykkö, OT; Nerg, O; Niskasaari, HM; Niskasaari, T; Koivisto, AM; Hiltunen, M; Pihlajamäki, J; Rauramaa, T; Kojoukhova, M; Alafuzoff, I; Soininen, H; Jääskeläinen, JE; Leinonen, V, 2018, World neurosurgery, 112, e624-e631. A1 Journal article (refereed), original research

Interrelationship between the Levels of C9orf72 and Amyloid-ß Protein Precursor and Amyloid-ß in Human Cells and Brain Samples

Leskelä, S; Takalo, M; Marttinen, M; Huber, N; Paananen, J; Mitra, V; Rauramaa, T; Mäkinen, P; Leinonen, V; Soininen, H; Pike, I; Remes, AM; Hiltunen, M; Haapasalo, A, 2018, Journal of Alzheimer's disease, 62, 1, 269-278. A1 Journal article (refereed), original research

Long-Term Outcome of Spinal Cord Stimulation in Failed Back Surgery Syndrome: 20 Years of Experience With 224 Consecutive Patients

Nissen, Mette; Ikäheimo, Tiina-Mari; Huttunen, Jukka; Leinonen, Ville; von Und Zu Fraunberg, Mikael, 2018, Neurosurgery, 2019; 84, 5, 1011-1018. A1 Journal article (refereed), original research

Molecular Mechanisms of Synaptotoxicity and Neuroinflammation in Alzheimer's Disease

Marttinen, Mikael; Takalo, Mari; Natunen, Teemu; Wittrahm, Rebekka; Gabbouj, Sami; Kemppainen, Susanna; Leinonen, Ville; Tanila, Heikki; Haapasalo, Annakaisa; Hiltunen, Mikko, 2018, Frontiers in neurology, 12, 963. A2 Review article, Literature review, Systematic review

Neurokirurgia ja neurotautien yksilöllistetty hoito Suomessa

Niemelä, Mika; Leinonen, Ville; Koivisto, Timo; Kumpulainen, Timo; Öhman, Juha; Rinne, Jaakko; Jääskeläinen, Juha E, 2018, Leppäniemi, Ari; Kuokkanen, Hannu; Salminen, Pauliina, Kirurgia, 874-875. D2 Article in a professional book (incl. an introduction by the editor)

Neurokirurgisesti hoidettavien tautien oireet ja kuvantaminen

Leinonen, Ville; Jääskeläinen, Juha E, 2018, Leppäniemi, Ari; Kuokkanen, Hannu; Salminen, Pauliina, Kirurgia, 880-882. D2 Article in a professional book (incl. an introduction by the editor)

Prevalence of Schizophrenia in Idiopathic Normal Pressure Hydrocephalus

Vanhala, V; Junkkari, A; Korhonen, VE; Kurki, MI; Hiltunen, M; Rauramaa, T;, Nerg, O;, Koivisto, AM; Remes, AM; Perälä, J; Suvisaari, J; Lehto, S; Viinamäki, H; Soininen, H; Jääskeläinen, JE; Leinonen, V, 2018, Neurosurgery, 2019; 84, 4, 883-889. A1 Journal article (refereed), original research

Spinaalikanavan sairaudet

Leinonen, Ville; Jääskeläinen, Juha E, 2018, Leppäniemi, Ari; Kuokkanen, Hannu; Salminen, Pauliina, Kirurgia, 938-951. D2 Article in a professional book (incl. an introduction by the editor)

Sushi repeat-containing protein X-Linked 2 - a novel phylogenetically conserved hypothalamo-pituitary protein

Anwer, M; Bolkvadze, T; Ndode-Ekane, XE; Puhakka, N; Rauramaa, T; Leinonen, V; van Vliet, EA; Swaab, DF; Haapasalo, A; Leskelä, S; Bister, N; Malm, T; Carlson, S; Aronica, E; Pitkänen, A, 2018, Journal of comparative neurology, 526, 11, 1806-1819. A1 Journal article (refereed), original research

Value stream map assessment of the extended day: 23h surgery model

Ruohoaho, Ulla-Maija; Kokki, Merja; Hirvonen, Jouni; Joukainen, Sarianna; Aaltomaa, Sirpa; von und zu Fraunberg, Mikael; Leinonen, Ville; Reijula, Jori, 2018, Intelligent buildings international, [Epub 21 MAR 2018]. A1 Journal article (refereed), original research

Alzheimer's Disease-Related Polymorphisms in Shunt-Responsive Idiopathic Normal Pressure Hydrocephalus

Huovinen J, Helisalmi S, Paananen J, Laiterä T, Kojoukhova M, Sutela A, Vanninen R, Laitinen M, Rauramaa T, Koivisto AM, Remes AM, Soininen H, Kurki M, Haapasalo A, Jääskeläinen JE, Hiltunen M, Leinonen V, 2017, Journal of Alzheimer's disease, 60, 3, 1077-1085. A1 Journal article (refereed), original research

Cerebrospinal fluid circulation and hydrocephalus

Leinonen V, Vanninen R, Rauramaa T, 2017, Kovacs Gabor G, Alafuzoff Irina, Handbook of Clinical Neurology. Neuropathology, 39-50. A3 Book section, Chapters in research books

Frontotemporal dementia as a comorbidity to idiopathic normal pressure hydrocephalus (iNPH): a short review of literature and an unusual case

Korhonen VE, Solje E, Suhonen NM, Rauramaa T, Vanninen R, Remes AM, Leinonen V, 2017, Fluids and barriers of the cns, 14, 10. A2 Review article, Literature review, Systematic review

Immunohistochemical Characterization and Sensitivity to Human Adenovirus Serotypes 3, 5, and 11p of New Cell Lines Derived from Human Diffuse Grade II to IV Gliomas

Niittykoski Minna, von und zu Fraunberg Mikael, Martikainen Miika, Rauramaa, Immonen Arto, Koponen Susanna, Leinonen Ville, Vähä-Koskela Markus, Zhang Qiwei, Kühnel Florian, Mei Ya-Fang, Ylä-Herttuala Seppo, Jääskeläinen Juha E, Hinkkanen Ari, 2017, Translational oncology, 10, 5, 772-779. A1 Journal article (refereed), original research

Niskakipu (aikuiset) : Käypä hoito -suositus (Päivitystiivistelmä)

Karppinen Jaro, Laimi Katri, Leinonen Ville, Malmivaara Antti, Niinimäki Jaakko, Airaksinen Olavi, Arokoski Jari, Auvinen Juha, Jääskeläinen Juhani, Martimo Kari-Pekka, Salo Petri, Soinne Lauri, 2017, Duodecim, 133, 7, 699-700. D1 Article in a trade journal

Raised intracranial pressure and brain edema

Leinonen V, Vanninen R, Rauramaa T, 2017, Kovacs Gabor G, Alafuzoff Irina, Handbook of Clinical Neurology. Neuropathology, 25-37. A3 Book section, Chapters in research books

Rate and Risk Factors for Shunt Revision in Pediatric Patients with Hydrocephalus- A Population-Based Study

Tervonen Joona, Leinonen Ville, Jääskeläinen Juha E, Koponen Susanna, Huttunen Terhi J, 2017, World neurosurgery, 101, 615-622. A1 Journal article (refereed), original research

Why does the health-related quality of life in idiopathic normal pressure hydrocephalus fail to improve despite the favorable clinical outcome?

Junkkari Antti, Roine Risto P, Luikku Antti, Rauramaa Tuomas, Sintonen Harri, Nerg Ossi, Koivisto Anne M, Häyrinen Antti, Viinamäki Heimo, Soininen Hilkka, Jääskeläinen Juha E, Leinonen Ville, 2017, World neurosurgery, 108, 356-366. A1 Journal article (refereed), original research

Aneurysmal Subarachnoid Hemorrhage Patients' Risk Assessment for Shunting (aSAH-PARAS): An International Collaborative Study and Initiation of a Consortium

Adams H, Ban VS, Leinonen V, Aoun SG, Huttunen J, Saavalainen T, Lindgren A, Frosen J, Fraunberg M, Koivisto TS, Hernesniemi JA, Welch BG, Jääskeläinen J, 2016, Neurosurgery.

Associations of intracranial pressure with brain biopsy, radiological findings, and shunt surgery outcome in patients with suspected idiopathic normal pressure hydrocephalus

Kojoukhova Maria, Vanha Krista-Irina, Timonen Matti, Koivisto Anne M, Nerg Ossi, Rummukainen Jaana, Rauramaa Tuomas, Vanninen Ritva, Jääskeläinen Juha E, Sutela Anna, Leinonen Ville, 2016, Acta neurochirurgica, 2017; 159, 1, 51-61. A1 Journal article (refereed), original research

Effects of Alzheimer's Disease-Associated Risk Loci on Amyloid-ß Accumulation in the Brain of Idiopathic Normal Pressure Hydrocephalus Patients

Laiterä Tiina, Paananen Jussi, Helisalmi Seppo, Sarajärvi Timo, Huovinen Joel, Laitinen Marjo, Rauramaa Tuomas, Alafuzoff Irina, Remes Anne M, Soininen Hilkka, Haapasalo Annakaisa, Jääskeläinen Juha E, Leinonen Ville, Hiltunen Mikko, 2016, Journal of Alzheimer's disease, 2017; 55, 3, 995-1003. A1 Journal article (refereed), original research

Familial idiopathic normal pressure hydrocephalus

Huovinen J, Kastinen S, Komulainen S, Oinas M, Avellan C, Frantzen J, Rinne J, Ronkainen A, Kauppinen M, Lönnrot K, Perola M, Pyykkö OT, Koivisto AM, Remes AM, Soininen H, Hiltunen M, Helisalmi S, Kurki M, Jääskeläinen JE, Leinonen V, 2016, Journal of the neurological sciences, 368, 11-18. A1 Journal article (refereed), original research

Health-related quality-of-life outcome in patients with idiopathic normal-pressure hydrocephalus - a 1-year follow-up study

Junkkari A, Häyrinen A, Rauramaa T, Sintonen H, Nerg O, Koivisto AM, Roine RP, Viinamäki H, Soininen H, Luikku A, Jääskeläinen JE, Leinonen V, 2016, European journal of neurology, 24, 1, 58-66. A1 Journal article (refereed), original research

High Risk of Dementia in Ventricular Enlargement with Normal Pressure Hydrocephalus Related Symptoms1

Koivisto Anne M, Kurki Mitja, Alafuzoff Irina, Sutela Anna, Rummukainen Jaana, Savolainen Sakari, Vanninen Ritva, Jääskeläinen Juha E, Soininen Hilkka, Leinonen Ville, 2016, Journal of Alzheimer's disease, 52, 2, 497-507. A1 Journal article (refereed), original research

Hätäkraniotomiat Pohjois-Karjalan keskussairaalassa vuosina 2006 - 2014

Aro Ellinoora, Jääskeläinen Juha E, Reinikainen Matti, Leinonen Ville, Hakala Tapio, 2016, Duodecim, 132, 9, 858-65. A1 Journal article (refereed), original research

Implantable RF-coil with multiple electrodes for long-term EEG-fMRI monitoring in rodents

Pirttimäki T, Salo RA, Shatillo A, Kettunen MI, Paasonen J, Sierra A, Jokivarsi K, Leinonen V, Andrade P, Quittek S, Pitkänen A, Gröhn O, 2016, Journal of neuroscience methods, 274, 154-163. A1 Journal article (refereed), original research

Multimodal analysis to predict shunt surgery outcome of 284 patients with suspected idiopathic normal pressure hydrocephalus

Luikku Antti J, Hall Anette, Nerg Ossi, Koivisto Anne M, Hiltunen Mikko, Helisalmi Seppo, Herukka Sanna-Kaisa, Sutela Anna, Kojoukhova Maria, Mattila Jussi, Lötjönen Jyrki, Rummukainen Jaana, Alafuzoff Irina, Jääskeläinen Juha E, Remes Anne M, Soininen Hilkka, Leinonen Ville, 2016, Acta neurochirurgica, 158, 12, 2311-2319. A1 Journal article (refereed), original research

Risk of shunting after aneurysmal subarachnoid hemorrhage: a collaborative study and initiation of a consortium

Adams H, Ban VS, Leinonen V, Aoun SG, Huttunen J, Saavalainen T, Lindgren A, Frosen J, Fraunberg M, Koivisto T, Hernesniemi J, Welch BG, Jaaskelainen JE, Huttunen TJ, 2016, Stroke, 47, 10, 2488-96. A1 Journal article (refereed), original research

SEPT8 modulates ß-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1

Kurkinen Kaisa MA, Marttinen Mikael, Turner Laura, Natunen Teemu, Mäkinen Petra, Haapalinna Fanni, Sarajärvi Timo, Gabbouj Sami, Kurki Mitja, Paananen Jussi, Koivisto Anne M, Rauramaa Tuomas, Leinonen Ville, Tanila Hanila, Soininen Hilkka, Lucas Fiona R, Haapasalo Annakaisa, Hiltunen Mikko, 2016, Journal of cell science, 129, 2224-2238. A1 Journal article (refereed), original research

Selling vs. non-selling neuro-oncology research cohorts and manuscripts in the eyes of a grumpy reviewer after 2,000 reviews

Leinonen Ville, Jääskeläinen Juha E, 2016, Acta neurochirurgica, 2017; 159, 1, 3-6. A1 Journal article (refereed), original research

Sub-classification based specific movement control exercises are superior to general exercise in sub-acute low back pain when both are combined with manual therapy: A randomized controlled trial

Lehtola Vesa, Luomajoki Hannu, Leinonen Ville, Gibbons Sean, Airaksinen Olavi, 2016, Bmc musculoskeletal disorders, 17, 1, 135. A1 Journal article (refereed), original research

Amyloid-ß and Tau Dynamics in Human Brain Interstitial Fluid in Patients with Suspected Normal Pressure Hydrocephalus

Herukka Sanna-Kaisa, Rummukainen Jaana, Ihalainen Jouni, von und zu Fraunberg Mikael, Koivisto Anne M, Nerg Ossi, Puli Lakshman K, Seppälä Toni T, Zetterberg Henrik, Pyykkö Okko T, Helisalmi Seppo, Tanila Heikki, Alafuzoff Irina, Hiltunen Mikko, Rinne Jaakko, Soininen Hilkka, Jääskeläinen Juha E, Leinonen Ville, 2015, Journal of Alzheimer's disease, 46, 1, 261-269. A1 Journal article (refereed), original research

Analysis of disruptive events and precarious situations caused by interaction with neurosurgical microscope

Eivazi Shahram, Afkari Hoorieh, Bednarik Roman, Leinonen Ville, Tukiainen Markku, Jääskeläinen Juha E, 2015, Acta neurochirurgica, 157, 7, 1147-1154. A1 Journal article (refereed), original research

Chasing the effects of pre-analytical confounders - a multicenter study on CSF-AD biomarkers

Leitão Maria João, Baldeiras Inês, Herukka Sanna-Kaisa, Pikkarainen Maria, Leinonen Ville, Simonsen Anja Hviid, Perret-Liaudet Armand, Fourier Anthony, Quadrio Isabelle, Veiga Pedro Mota, de Oliveira Catarina Resende, 2015, Frontiers in neurology, 6, 153. A1 Journal article (refereed), original research

Effects of Alzheimer's Disease-Associated Risk Loci on Cerebrospinal Fluid Biomarkers and Disease Progression: A Polygenic Risk Score Approach

Martiskainen Henna, Helisalmi Seppo, Viswanathan Jayashree, Kurki Mitja, Hall Anette, Herukka Sanna-Kaisa, Sarajärvi Timo, Natunen Teemu, Kurkinen Kaisa M.A., Huovinen Jaakko, Mäkinen Petra, Laitinen Marjo, Koivisto Anne M., Mattila Kari M., Lehtimäki Terho, Remes Anne M., Leinonen Ville, Haapasalo Annakaisa, Soininen Hilkka, Hiltunen Mikko, 2015, Journal of Alzheimer's disease, 43, 2, 565-573. A1 Journal article (refereed), original research

Embedding an Eye Tracker into a Surgical Microscope: Requirements, Design, and Implementation

Eivazi Shahram, Bednarik R, Leinonen V, von und zu Fraunberg M, Jääskeläinen JE, 2015, IEEE sensors journal, 2016; 16, 7, 2070-2078. A1 Journal article (refereed), original research

Feasibility of radiological markers in idiopathic normal pressure hydrocephalus

Kojoukhova Maria, Koivisto Anne M, Korhonen Riiika, Remes Anne M, Vanninen Ritva, Soininen Hilkka, Jääskeläinen Juha E, Sutela Anna, Leinonen Ville, 2015, Acta neurochirurgica, 157, 10, 1709-1719. A1 Journal article (refereed), original research

Genetic Variation in delta-Opioid Receptor Associates with Increased ß- and gamma-Secretase Activity in the Late Stages of Alzheimer's Disease

Sarajärvi Timo, Marttinen Mikael, Natunen Teemu, Kauppinen Tarja, Mäkinen Petra, Helisalmi Seppo, Laitinen Marjo, Rauramaa Tuomas, Leinonen Ville, Petäjä-Repo Ulla, Soininen Hilkka, Haapasalo Annakaisa, Hiltunen Mikko, 2015, Journal of Alzheimer's disease, 48, 2, 507-516. A1 Journal article (refereed), original research

Health-related quality of life in patients with idiopathic normal pressure hydrocephalus

Junkkari A, Sintonen H, Nerg O, Koivisto AM, Roine RP, Viinamäki H, Soininen H, Jääskeläinen JE, Leinonen V, 2015, European journal of neurology, published online 24 JUN 2015, 9 p. A1 Journal article (refereed), original research

Normaalipaineinen hydrokefalia

Leinonen Ville, Koivisto Anne, 2015, Timo Erkinjuntti, Anne Remes, Juha Rinne, Hilkka Soininen, Muistisairaudet, 187-193. A3 Book section, Chapters in research books

Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models

Natunen Teemu, Takalo Mari, Kemppainen Ssusanna, Leskelä Stina, Marttinen Mikael, Kurkinen Kaisa MA, Pursiheimo Juha-Pekka, Sarajärvi Timo, Viswanathan Jayashree, Gabbouj Sami, Solje Eino, Tahvanainen Eveliina, Pirttimäki Tiina, Kurki Mitja, Paananen Jussi, Rauramaa Tuomas, Miettinen Pasi, Mäkinen Petra, Leinonen Ville, Soininen Hilkka et al, 2015, Neurobiology of disease, 2016; 85, 187-205. A1 Journal article (refereed), original research

The Expression of Transthyretin and Amyloid-ß Protein Precursor is Altered in the Brain of Idiopathic Normal Pressure Hydrocephalus Patients

Laiterä Tiina, Kurki Mitja I, Pursiheimo Juha-Pekka, Zetterberg Henrik, Helisalmi Seppo, Rauramaa Tuomas, Alafuzoff Irina, Remes Anne M, Soininen Hilkka, Haapasalo Annakaisa, Jääskeläinen Juha E, Hiltunen Mikko, Leinonen Ville, 2015, Journal of Alzheimer's disease, 48, 4, 959-968. A1 Journal article (refereed), original research

The effect of decompressive surgery on lumbar paraspinal and biceps brachii muscle function and movement perception in lumbar spinal stenosis: a 2-year follow-up

Kääriäinen Tommi, Taimela Simo, Aalto Timo, Kröger Heikki, Herno Arto, Turunen Veli, Savolainen Sakari, Kankaanpää Markku, Airaksinen Olavi, Leinonen Ville, 2015, European spine journal, 2016; 25, 3, 789-794. A1 Journal article (refereed), original research

Alaselkäkipu: Käypä hoito -suositus

Pohjolainen T, Leinonen V, Frantzén J, Haanpää M, Jousimaa JP, Karppinen J, Kuukkanen T, Luoma K, Salmenkivi J, Österman H, Malmivaara A, 2014, Duodecim, hoi20001, artikkeli netissä. A1 Journal article (refereed), original research

Association between bone mineral density and lumbar disc degeneration

Salo Sami, Leinonen Ville, Rikkonen Tomi, Vainio Pauli, Marttila Jarkko, Honkanen Risto, Tuppurainen Marjo, Kröger Heikki, Sirola Joonas, 2014, Maturitas, S0378-5122, 14, 00290-4. A1 Journal article (refereed), original research

Cerebrospinal Fluid Biomarker and Brain Biopsy Findings in Idiopathic Normal Pressure Hydrocephalus

Pyykkö OT, Lumela M, Rummukainen J, Nerg O, Seppälä TT, Herukka SK, Koivisto AM, Alafuzoff I, Puli L, Savolainen S, Soininen H, Jääskeläinen JE, Hiltunen M, Zetterberg H, Leinonen V, 2014, PLoS ONE, 9, 3; e91974, 1-10. A1 Journal article (refereed), original research

Correlation of lateral stenosis in MRI with symptoms, walking capacity and EMG findings in patients with surgically confirmed lateral lumbar spinal canal stenosis

Kuittinen Pekka, Sipola Petri, Aalto Timo Juhani, Määttä Sara, Parviainen Anita, Saari Tapani, Sinikallio Sanna, Savolainen Sakari, Turunen Veli, Kröger Heikki, Airaksinen Olavi, Leinonen Ville, 2014, Bmc musculoskeletal disorders, 15, 247. A1 Journal article (refereed), original research

Diagnostic effectiveness of quantitative [18F]flutemetamol PET imaging for detection of fibrillar amyloid ß using cortical biopsy histopathology as the standard of truth in subjects with idiopathic normal pressure hydrocephalus

Leinonen V, Rinne JO, Wong DF, Wolk DA, Trojanowski JQ, Sherwin PF, Smith A, Heurling K, Su M, Grachev ID, 2014, Acta neuropathologica communications, 2, 1, 46. A1 Journal article (refereed), original research

High-fat diet increases tau expression in the brain of T2DM and AD mice independently of peripheral metabolic status

Takalo M, Haapasalo A, Martiskainen H, Kurkinen KM, Koivisto H, Miettinen P, Khandelwal VK, Kemppainen S, Kaminska D, Mäkinen P, Leinonen V, Pihlajamäki J, Soininen H, Laakso M, Tanila H, Hiltunen M, 2014, Journal of nutritional biochemistry, 25, 6, 634-641. A1 Journal article (refereed), original research

Increased y-Secretase Activity in Idiopathic Normal Pressure Hydrocephalus Patients with b-Amyloid Pathology

Laiterä T, Sarajärvi T, Haapasalo A, Puli L, Kauppinen T, Mäkinen P, Rauramaa T, Tanila H, Jääskeläinen JE, Alafuzoff I, Soininen H, Leinonen V, Hiltunen M, 2014, PLoS ONE, 3, 9: e93717, 1-8. A1 Journal article (refereed), original research

Preoperative MRI Findings Predict Two-Year Postoperative Clinical Outcome in Lumbar Spinal Stenosis

Kuittinen P, Sipola P, Leinonen V, Saari T, Sinikallio S, Savolainen S, Kröger H, Turunen V, Airaksinen O, Aalto T, 2014, PLoS ONE, 9, 9, e106404. A1 Journal article (refereed), original research

Transcriptomics and mechanistic elucidation of Alzheimer's disease risk genes in the brain and in vitro models

Martiskainen H, Viswanathan J, Nykänen NP, Kurki M, Helisalmi S, Natunen T, Sarajärvi T, Kurkinen KM, Pursiheimo JP, Rauramaa T, Alafuzoff I, Jääskeläinen JE, Leinonen V, Soininen H, Haapasalo A, Huttunen HJ, Hiltunen M, 2014, Neurobiology of aging, 36, 2, 1221.e15-1221.e28. A1 Journal article (refereed), original research

Visually assessed severity of lumbar spinal canal stenosis is paradoxically associated with leg pain and objective walking ability

Kuittinen Pekka, Sipola Petri, Saari Tapani, Aalto Timo Juhani, Sinikallio Sanna, Savolainen Sakari, Kröger Heikki, Turunen Veli, Leinonen Ville, Airaksinen Olavi, 2014, Bmc musculoskeletal disorders, 15, 1, 348. A1 Journal article (refereed), original research

Association of Modic changes with health-related quality of life among patients referred to spine surgery

Määttä J, Kautiainen H, Leinonen V, Niinimäki J, Järvenpää S, Koskelainen T, Mäkelä P, Pesälä J, Nyyssönen T, Savolainen S, Airaksinen O, Kyllönen E, Cheung KMC, Karppinen J, 2013, Scandinavian journal of pain, Volume 5, Issue 1, January 2014, 36-40. A1 Journal article (refereed), original research

Content validity and responsiveness of a Finnish version of the Patient-Specific Functional Scale

Lehtola V, Kaksonen A, Luomajoki H, Leinonen V, Gibbons S, Airaksinen O, 2013, European journal of physiotherapy, 15, 3, 134-138. A1 Journal article (refereed), original research

Education of research ethics for clinical investigators with Moodle tool

Halkoaho A, Matveinen M, Leinonen V, Luoto K, Keränen T, 2013, Bmc medical ethics, 14, 53. A1 Journal article (refereed), original research

Effects of NR1H3 genetic variation on the expression of liver X receptor alfa and the progression of Alzheimer's Disease

Natunen Teemu, Martiskainen Henna, Sarajärvi Timo, Helisalmi Seppo, Pursiheimo Juha-Pekka, Viswanathan Jayashree, Laitinen Marjo, Kauppinen Tarja, Rauramaa Tuomas, Leinonen Ville, Alafuzoff Irina, Haapasalo Annakaisa, Soininen Hilkka, Hiltunen Mikko, 2013, PLoS ONE, 8, 11, e80700. A1 Journal article (refereed), original research

Influence of comorbidities in idiopathic normal pressure hydrocephalus - research and clinical care. A report of the ISHCSF task force on comorbidities in INPH.

Malm J, Graff-Radford NR, Ishikawa M, Kristensen B, Leinonen V, Mori E, Owler BK, Tullberg M, Williams MA, Relkin NR, 2013, Fluids and barriers of the cns, 10, 1, 22. A1 Journal article (refereed), original research

Poor cognitive outcome in shunt-responsive idiopathic normal pressure hydrocephalus

Koivisto AM, Alafuzoff I, Savolainen S, Sutela A, Rummukainen J, Kurki M, Jääskeläinen JE, Soininen H, Rinne J, Leinonen V,, 2013, Neurosurgery, 72, 1, 1-8. A1 Journal article (refereed), original research

Positron emission tomography with [18F]flutemetamol and [11C]PiB for in vivo detection of cerebral cortical amyloid in normal pressure hydrocephalus patients

Leinonen V, Rinne JO, Virtanen KA, Eskola O, Rummukainen J, Huttunen J, von Und Zu Fraunberg M, Nerg O, Koivisto AM, Rinne J, Jääskeläinen JE, Buckley C, Smith A, Jones PA, Sherwin P, Farrar G, McLain R, Kailajärvi M, Heurling K, Grachev ID, 2013, European journal of neurology, 20, 7, 1043-52. A1 Journal article (refereed), original research

Prospective Flutemetamol Positron Emission Tomography and Histopathology in Normal Pressure Hydrocephalus

Rinne JO, Frantzen J, Leinonen V, Lonnrot K, Laakso A, Virtanen KA, Solin O, Kotkansalo A, Koivisto A, Sajanti J, Karppinen A, Lehto H, Rummukainen J, Buckley C, Smith A, Jones PA, Sherwin P, Farrar G, McLain R, Kailajarvi M, Grachev ID, 2013, Neurodegenerative diseases, epub ahead of print, 9 sivua. A1 Journal article (refereed), original research

APOE4 predicts amyloid-&#946 in cortical brain biopsy but not idiopathic normal pressure hydrocephalus

Pyykkö OT, Helisalmi S, Koivisto AM, Mölsä JA, Rummukainen J, Nerg O, Alafuzoff I, Savolainen S, Soininen H, Jääskeläinen JE, Rinne J, Leinonen V, Hiltunen M, 2012, Journal of neurology neurosurgery and psychiatry, 83, 11, 1119-1124. A1 Journal article (refereed), original research

Accuracy and reproducibility of a retrospective outcome assessement for lumbar spinal stenosis surgery

Kuittinen P, Aalto T, Heikkilä T, Leinonen V, Savolainen S, Sipola P, Kröger H, Turunen V, Airaksinen O, 2012, Bmc musculoskeletal disorders, 13, 83. A1 Journal article (refereed), original research

CSF biomarkers for Alzheimer disease correlate with cortical brain biopsy findings

Seppälä TT, Nerg O, Koivisto AM, Rummukainen J, Puli L, Zetterberg H, Pyykkö OT, Helisalmi S, Alafuzoff I, Hiltunen M, Jääskeläinen JE, Rinne J, Soininen H, Leinonen V, Herukka S-K, 2012, Neurology, 78, 1568-1575. A1 Journal article (refereed), original research

Cortical brain biopsy in long-term prognostication of 468 patients with possible normal pressure hydrocephalus

Leinonen V, Koivisto AM, Alafuzoff I, Pyykkö OT, Rummukainen J, von Und Zu Fraunberg M, Jääskeläinen JE, Soininen H, Rinne J, Savolainen S, 2012, Neurodegenerative diseases, 10, 1-4, 166-169. A1 Journal article (refereed), original research

Efficacy of movement control exercises versus general exercises on recurrent sub-acute nonspecific low back pain in a sub-group of patients with movement control dysfunction. Protocol of a randomized controlled trial.

Lehtola V, Luomajoki H, Leinonen V, Gibbons S, Airaksinen O, 2012, Bmc musculoskeletal disorders, 13, 55: 1-9. A1 Journal article (refereed), original research

Lumbar paraspinal and biceps brachii muscle function and movement perception in lumbar spinal stenosis

Kääriäinen T, Leinonen V, Taimela S, Aalto T, Kröger H, Herno A, Turunen V, Savolainen S, Kankaanpää M, Airaksinen O, 2012, European spine journal, 2012, 6 sivua. A1 Journal article (refereed), original research

Post-mortem findings in 10 patients with presumed normal-pressure hydrocephalus and review of the literature

Leinonen V, Koivisto AM, Savolainen S, Rummukainen J, Sutela A, Vanninen R, Jääskeläinen JE, Soininen H, Alafuzoff I, 2012, Neuropathology and applied neurobiology, 38, 1, 72-86. A1 Journal article (refereed), original research

Preoperative predictors for good postoperative satisfaction and functional outcome in lumbar spinal stenosis surgery - A prospective observational study with a two-year follow-up

Aalto T, Sinikallio S, Kröger H, Viinamäki H, Herno A, Leinonen V, Turunen V, Savolainen S, Airaksinen O, 2012, Scandinavian journal of surgery, 101, 255-260. A1 Journal article (refereed), original research

[(18)F]Flutemetamol PET imaging and cortical biopsy histopathology for fibrillar amyloid &#946 detection in living subjects with normal pressure hydrocephalus: pooled analysis of four studies

Rinne JO, Wong DF, Wolk DA, Leinonen V, Arnold SE, Buckley C, Smith A, McLain R, Sherwin PF, Farrar G, Kailajärvi M, Grachev ID, 2012, Acta neuropathologica, 124, 6, 833-845. A1 Journal article (refereed), original research

Amyloid-beeta and Hyperphospholated Tau in the Prediction of Azheimer's Disease

Rummukainen J, Koivisto AM, Alafuzoff I, Leinonen V, 2011, European neurological review, 6, 2, 84-88. A1 Journal article (refereed), original research

Cerebrospinal Fluid Biomarkers in Idiopathic Normal Pressure Hydrocephalus

Leinonen V, Menon LG, Carroll RS, Dello Iacono D, Grevet J, Jääskeläinen JE, Black PM, 2011, International journal of alzheimer's disease, 2011, 1-6. A1 Journal article (refereed), original research

Postoperative rehabilitation does not improve functional outcome in lumbar spinal stenosis: a prospective study with 2-year postoperative follow-up

Aalto, Timo J; Leinonen, Ville; Herno, Arto; Alen, Markku; Kröger, Heikki; Turunen, Veli; Savolainen, Sakari; Saari, Tapani; Airaksinen, Olavi, 2011, European spine journal, 20, 8, 1331-1340. A1 Journal article (refereed), original research

Visual and quantitative assessment of lateral lumbar spinal canal stenosis with magnetic resonance imaging

Sipola P, Leinonen V, Niemeläinen R, Aalto T, Vanninen R, Manninen H, Airaksinen O, Battié MC, 2011, Acta radiologica, 52, 9, 1024-1031. A1 Journal article (refereed), original research

Muistisairaudet

Erkinjuntti T, Rinne J & Soininen H, 2010, WS Bookwell Oy. C1 Book

Assessment of beta-amyloid in a frontal cortical brain biopsy specimen and by positron emission tomography with carbon 11- labeled Pittsburgh compound B

Leinonen V, Alafuzoff I, Aalto S, Suotunen T, Savolainen S, Någren K, Tapiola T, Pirttilä T, Rinne J, Jääskeläinen JE, Soininen H, Rinne J, Pirttilä T, Soininen H, 2008, Archives of neurology, 65, 10, 1304-1309. A1 Journal article (refereed), original research

The amyloid beta-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae

Hansson Petersen CA, Alikhani N, Behbahani H, Wiehanger B, Pavlov PV, Alafuzoff I, Leinonen V, Ito A, Winbland B, Glaser E, Ankarcrona M, 2008, Proceedings of the National Academy of Sciences of the United States of America, 105, 35, 13145-13150. A1 Journal article (refereed), original research

Postural control in male patients with hip osteoarthritis

Arokoski JPA, Leinonen V, Arokoski MH, Aalto H, Valtonen H, 2006, Gait and posture, 23, 45-50. A1 Journal article (refereed), original research

Back and neck extensor loading and back pain provocation in urban bus drivers with and without low back pain

Leinonen V, Kankaanpää M, Vanharanta H, Airaksinen O, Hänninen O, 2005, Pathophysiology, 12, 249-55. A1 Journal article (refereed), original research

Indigenous healers' explanations of low back pain and its relief

Räsänen V, Leinonen V, Zaproudina N, 2005, Pathophysiology, 12, 313-316. A1 Journal article (refereed), original research

Wireless on-line electromyography in recording neck muscle function: A pilot study

Airaksinen MK, Kankaanpää M, Aranko O, Leinonen V, Arokoski JPA, Airaksinen O, 2005, Pathophysiology, 12, 303-306. A1 Journal article (refereed), original research

Lumbar paraspinal muscle function, perception of lumbar postition, and postural control in disc herniation-releted back pain

Leinonen V, Kankaanpää M, Luukonen M, Kansanen M, Hänninen O, Airaksinen O, Taimela S, 2003, Spine, 28, 8, 842-848. A1 Journal article (refereed), original research

Neuromuscular Control in Lumbar Disorders

Leinonen V, 2003, Kuopio University Publications D. Medical Sciences. G5 Doctoral dissertation (article)

Paraspinal muscle denervation, paradoxically good lumbar endurance, and an abnormal flexion-extension cycle in lumbar spinal stenosis

Leinonen V, Määttä S, Taimela S, Herno A, Kankaanpää M, Partanen J, Hänninen O, Airaksinen O, 2003, Spine, 28, 4, 324-331. A1 Journal article (refereed), original research

Impaired lumbar movement perception in association with postural stability and motor- and somatosensory-evoked potentials in lumbar spinal stenosis

Leinonen V, Määttä S, Taimela S, Herno A, Kankaanpää M, Partanen J, Kansanen M, Hänninen O, Airaksinen O, 2002, Spine, 27, 9, 975-983. A1 Journal article (refereed), original research

Disc herniation-related back pain impairs feed-forward control of paraspinal muscles

Leinonen V, Kankaanpää M, Luukkonen M, Hänninen O, Airaksinen O, Taimela S, 2001, Spine, 26, E367-E372. A1 Journal article (refereed), original research

Back and hip extensor activities during trunk flexion/extension: effects of low back pain and rehabilitation

Leinonen V, Kankaanpää M, Airaksinen O, Hänninen O, 2000, Archives of physical medicine and rehabilitation, 81, 32-37. A1 Journal article (refereed), original research

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A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer's disease

A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer’s disease

Ageing and higher BMI explain movement control impairment distinctly better than chronic pain and its contributing factors: A cross-sectional study of 161 subjects with chronic low back pain and 42 pain-free controls

Alaselkäkivun Käypä hoito -suositus : kohti kokonaisvaltaisempaa hoitoa ja kuntoutusta

Altered tear fluid protein expression in persons with mild Alzheimer's disease in proteins involved in oxidative stress, protein synthesis, and energy metabolism

Biopsies from Idiopathic Normal Pressure Hydrocephalus Patients as a Window to the Events of Early Alzheimer's disease: Beta‐amyloid and Tau Pathologies Alter Synaptic Transmission in Human Brain

Cerebrospinal fluid proteome profiling across the Alzheimer’s disease continuum: a step towards solving the equation for ‘X’

Discovery of Novel CSF Clearance Mechanism of Idiopathic Normal Pressure Hydrocephalus and Alzheimer's Disease

Drainage Volume, Drainage Time, and Irrigation Volume in Chronic Subdural Hematoma

Effect of ventricular volume on cerebrospinal fluid Alzheimer's disease biomarkers in patients with idiopathic normal pressure hydrocephalus

Failure to improve — identifying risk factors for poor functional recovery following chronic subdural hematoma surgery

Inflammation-induced lysosomal dysfunction in human iPSC-derived microglia is exacerbated by APOE 4/4 genotype

Low prevalence of CWH43 variants among Finnish and Norwegian idiopathic normal pressure hydrocephalus patients: a cohort-based observational study

Monoallelic TYROBP deletion is a novel risk factor for Alzheimer’s disease

Mortality and causes of death after surgery for chronic subdural hematoma: a post hoc study of the FINISH randomized trial

Multimodal approach to characterize surgically removed epileptogenic zone from patients with focal drug‐resistant epilepsy: From operating room to wet lab

Neuroinflammation Markers in Tear Fluid of Mild Alzheimer’s Disease

Normaalipaineinen hydrokefalia

Outcome after Anterior Cervical Decompression and Fusion – A Nationwide FinSpine Register Study of Independent Predictors of Outcome at 12 Months after Surgery for Degenerative Cervical Spine

Outcome measures after anterior cervical decompression and fusion surgery -non-respondents do not bias the results: A Finnish spine register (FinSpine) study

Rate and risk factors for shunt revision in pediatric patients with hydrocephalus during a 17-year study period: a retrospective, population-based study

Remote Monitoring Acceptance in Elderly Neurological Patients: Examining Sociodemographic Factors in the Pre-Implementation Phase

Restarting anticoagulation early versus late in patients with chronic subdural hematoma and atrial fibrillation (RELACS): a phase III international multicenter, randomized controlled, two-arm, assessor-blinded trial

Segment Anything for Dendrites from Electron Microscopy

Single Cell Transcriptomics of Paired CSF and Blood Immune Populations Reveals Unique Macrophage Population with Relevance to Alzheimer's Disease

Smart Rings in Remote Monitoring at Home: Older Patients' Perceptions and Expectations

The protective PLCγ2-P522R variant mitigates Alzheimer’s disease-associated pathologies by enhancing beneficial microglial functions

Well-being in pain questionnaire: A novel, reliable, and valid tool for assessment of the personal well-being in individuals with chronic low back pain

Ambulatory Care vs Overnight Hospitalization After Anterior Surgery for Cervical Radiculopathy

Burr-hole drainage with or without irrigation for chronic subdural haematoma (FINISH): a Finnish, nationwide, parallel-group, multicentre, randomised, controlled, non-inferiority trial

Considering the Potential Use of Oura Ring for Remote Monitoring at Home: The Perspective of Ageing Neurological Patients

Deep learning assisted quantitative analysis of Aβ and microglia in patients with idiopathic normal pressure hydrocephalus in relation to cognitive outcome

Dimensionality, reliability, and validity of the Finnish version of the pain catastrophizing scale in chronic low back pain

Exploring the Association Between Visual Field Testing and CERAD Neuropsychological Battery in Idiopathic Normal Pressure Hydrocephalus Patients

Gut Microbiome Changes in Patients With Idiopathic Normal Pressure Hydrocephalus

Human iPSC-derived pericyte-like cells carrying APP Swedish mutation overproduce beta-amyloid and induce cerebral amyloid angiopathy-like changes

Identical movement control exercises with and without synchronized breathing for chronic non-specific low back pain:A randomized pilot trial

Optimizing Feature Selection for Unbalanced Metabolomics Data with A Background Factor: A Comparative Study in Parkinson's Disease

Outcome and complications of operatively treated subaxial cervical spine injuries: A population-based retrospective cohort study

Risk Variants Associated With Normal Pressure Hydrocephalus: Genome-Wide Association Study in the FinnGen Cohort

Tear fluid reflects the altered protein expressions of Alzheimer's disease patients in proteins involved in protein repair and clearance system or the regulation of cytoskeleton

Utility of cortical tissue analysis in normal pressure hydrocephalus

Ventriculoperitoneal shunt patients and glaucoma: a cohort analysis of the NPH registry

Cerebrospinal Fluid Diagnostics of Alzheimer's Disease in Patients with Idiopathic Normal Pressure Hydrocephalus

Concordance of Alzheimer’s Disease-Related Biomarkers Between Intraventricular and Lumbar Cerebrospinal Fluid in Idiopathic Normal Pressure Hydrocephalus

Early Alzheimer's disease pathology in human cortex involves transient cell states

Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro

Normaalipaineisen hydrokefaluksen arvoitus

Novel cerebrospinal fluid biomarkers correlating with shunt responsiveness in patients with idiopathic normal pressure hydrocephalus

Operative Treatment of Tarlov Cysts - Outcomes and Predictors of Improvement after Surgery: A Series of 97 Consecutive Patients and a Systematic Review of Literature

Potent dual MAGL/FAAH inhibitor AKU-005 engages endocannabinoids to diminish meningeal nociception implicated in migraine pain

Protective Alzheimer's disease-associated APP A673T variant predominantly decreases sAPPβ levels in cerebrospinal fluid and 2D/3D cell culture models

Protocol of identical exercise programs with and without specific breathing techniques for the treatment of chronic non-specific low back pain: randomized feasibility trial with two-month follow-up

Reduced binding of apoE4 to complement factor H promotes amyloid‐β oligomerization and neuroinflammation

Serum Cathepsin S Levels Do Not Show Alterations in Different Clinical, Neuropathological, or Genetic Subtypes of Frontotemporal Dementia Patients nor in Comparison to Healthy Control Individuals

To what degree patient-reported symptoms of central sensitization, kinesiophobia, disability, sleep, and life quality associated with 24-h heart rate variability and actigraphy measurements?

Cerebrospinal fluid biomarkers that reflect clinical symptoms in idiopathic normal pressure hydrocephalus patients

Computer-based Eye-tracking Analysis of King-Devick Test Differentiates Persons With Idiopathic Normal Pressure Hydrocephalus From Cognitively Unimpaired

Editorial: Toward a better understanding of the pathophysiology and clinical management of idiopathic normal pressure hydrocephalus

Genome-wide meta-analysis for Alzheimer’s disease cerebrospinal fluid biomarkers

In vivo assessment of Lewy body and beta-amyloid copathologies in idiopathic normal pressure hydrocephalus: prevalence and associations with clinical features and surgery outcome

Incidence and risk factors of spinal cord stimulation for persistent or recurrent pain after lumbar spine surgery: a population-based study

Kaularangan luisen juuriaukkoahtauman kirurginen hoito

Neuropathological findings in possible normal pressure hydrocephalus: A post-mortem study of 29 cases with lifelines

Postural sway does not differentiate individuals with chronic low back pain, single and multisite chronic musculoskeletal pain, or pain-free controls: a cross-sectional study of 229 subjects

Serum total TDP-43 levels are decreased in frontotemporal dementia patients with C9orf72 repeat expansion or concomitant motoneuron disease phenotype

Shortening of Saccades as a Possible Easy-to-Use Biomarker to Detect Risk of Alzheimer’s Disease

The effect of antithrombotic therapy on the recurrence and outcome of chronic subdural hematoma after burr-hole craniostomy in a population-based cohort

The effect of shunt surgery on corticospinal excitability in idiopathic normal pressure hydrocephalus: a transcranial magnetic stimulation study

5-Year health-related quality of life outcome in patients with idiopathic normal pressure hydrocephalus

A Novel Genetic Marker for the C9orf72 Repeat Expansion in the Finnish Population

Alzheimerin taudin uudet riskigeenit - keskiössä mikrogliasolut

Cerebrospinal fluid dynamics in idiopathic intracranial hypertension: a literature review and validation of contemporary findings

Cross-Cultural Adaptation, Reliability, and Psychophysical Validation of the Pain and Sleep Questionnaire Three-Item Index in Finnish

Cross-cultural adaptation and validation of the Finnish version of the central sensitization inventory and its relationship with dizziness and postural control

Elevated CSF LRG and Decreased Alzheimer's Disease Biomarkers in Idiopathic Normal Pressure Hydrocephalus