Ville Leinonen
Professor
Institute of Clinical Medicine, School of Medicine, Faculty of Health Sciences
ville.leinonen@uef.fi
Research groups
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Brain Research Unit (BRU) - Clinical Trial Unit 01.01.2022 - -
Clinical Epilepsy Research 01.01.2010 - -
Clinical Research Centre (CRC) 01.01.2002 - -
NPH and Early AD 01.01.2010 - -
Pain Neuromodulation Group 01.01.2022 -
Projects
Publications
164 items-
Cerebrospinal Fluid Diagnostics of Alzheimer's Disease in Patients with Idiopathic Normal Pressure Hydrocephalus
Vanninen, Aleksi; Lukkarinen, Heikki; Kokkola, Tarja; Koivisto, Anne M.; Kokki, Merja; Musialowicz, Tadeusz; Hiltunen, Mikko; Zetterberg, Henrik; Leinonen, Ville; Herukka, Sanna Kaisa; Rauramaa, Tuomas. 2023. Journal of Alzheimer's disease. 94: 727-736 -
Concordance of Alzheimer’s Disease-Related Biomarkers Between Intraventricular and Lumbar Cerebrospinal Fluid in Idiopathic Normal Pressure Hydrocephalus
Lukkarinen, Heikki; Vanninen, Aleksi; Tesseur, Ina; Pemberton, Darrel; Van Der Ark, Peter; Kokkola, Tarja; Herukka, Sanna-Kaisa; Rauramaa, Tuomas; Hiltunen, Mikko; Blennow, Kaj; Zetterberg, Henrik; Leinonen, Ville. 2023. Journal of Alzheimer's disease. 91: 305-319 -
Early Alzheimer's disease pathology in human cortex involves transient cell states
Gazestani, Vahid; Kamath, Tushar; Nadaf, Naeem M; Dougalis, Antonios; Burris, SJ; Rooney, Brendan; Junkkari, Antti; Vanderburg, Charles; Pelkonen, Anssi; Gomez-Budia, Mireia; Välimäki, Nelli Noora; Rauramaa, Tuomas; Therrien, Martine; Koivisto, Anne M; Tegtmeyer, Matthew; Herukka, Sanna Kaisa; Abdulraouf, Abdulraouf; Marsh, Samuel E; Hiltunen, Mikko; Nehme, Ralda; Malm, Tarja; Stevens, Beth; Leinonen, Ville; Macosko, Evan Z. 2023. Cell. 186: 4438-4453.e23 -
Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro
Dolan, Michael-John; Therrien, Martine; Jereb, Saša; Kamath, Tushar; Gazestani, Vahid; Atkeson, Trevor; Marsh, Samuel E.; Goeva, Aleksandrina; Lojek, Neal M.; Murphy, Sarah; White, Cassandra M.; Joung, Julia; Liu, Bingxu; Limone, Francesco; Eggan, Kevin; Hacohen, Nir; Bernstein, Bradley E.; Glass, Christopher K.; Leinonen, Ville; Blurton-Jones, Mathew; Zhang, Feng; Epstein, Charles B.; Macosko, Evan Z.; Stevens, Beth. 2023. Nature immunology. 24: 1382-1390 -
Normaalipaineisen hydrokefaluksen arvoitus
Leinonen, Ville; Hiltunen, Mikko. 2023. Duodecim. 139: 340-342 -
Novel cerebrospinal fluid biomarkers correlating with shunt responsiveness in patients with idiopathic normal pressure hydrocephalus
Weiner, Sophia; Junkkari, Antti; Sauer, Mathias; Luikku, Antti; Rauramaa, Tuomas; Kokkola, Tarja; Herukka, Sanna-Kaisa; Blennow, Kaj; Zetterberg, Henrik; Leinonen, Ville; Gobom, Johan. 2023. Fluids and barriers of the cns. 20: . 40 -
Potent dual MAGL/FAAH inhibitor AKU-005 engages endocannabinoids to diminish meningeal nociception implicated in migraine pain
Della Pietra, Adriana; Krivoshein, Georgii; Ivanov, Konstantin; Giniatullina, Raisa; Jyrkkänen, Henna-Kaisa; Leinonen, Ville; Lehtonen, Marko; van den Maagdenberg, Arn MJM; Savinainen, Juha; Giniatullin, Rashid. 2023. Journal of headache and pain. 24: . 38 -
Protective Alzheimer's disease-associated APP A673T variant predominantly decreases sAPPβ levels in cerebrospinal fluid and 2D/3D cell culture models
Wittrahm, Rebekka; Takalo, Mari; Kuulasmaa, Teemu; Mäkinen, Petra M; Mäkinen, Petri; Končarević, Saša; Fartzdinov, Vadim; Selzer, Stefan; Kokkola, Tarja; Antikainen, Leila; Martiskainen, Henna; Kemppainen, Susanna; Marttinen, Mikael; Jeskanen, Heli; Rostalski, Hannah; Rahunen, Eija; Kivipelto, Miia; Ngandu, Tiia; Natunen, Teemu; Lambert, Jean-Charles; Tanzi, Rudolph E; Kim, Doo Yeon; Rauramaa, Tuomas; Herukka, Sanna-Kaisa; Soininen, Hilkka; Laakso, Markku; Pike, Ian; Leinonen, Ville; Haapasalo, . 2023. Neurobiology of disease. 182: -
Protocol of identical exercise programs with and without specific breathing techniques for the treatment of chronic non-specific low back pain: randomized feasibility trial with two-month follow-up
Mikkonen, Jani; Luomajoki, Hannu; Airaksinen, Olavi; Goubert, Liesbet; Leinonen, Ville. 2023. Bmc musculoskeletal disorders. 24: . 354 -
Reduced binding of apoE4 to complement factor H promotes amyloid‐β oligomerization and neuroinflammation
Chernyaeva, Larisa; Ratti, Giorgio; Teirilä, Laura; Fudo, Satoshi; Rankka, Uni; Pelkonen, Anssi; Korhonen, Paula; Leskinen, Katarzyna; Keskitalo, Salla; Salokas, Kari; Gkolfinopoulou, Christina; Crompton, Katrina E; Javanainen, Matti; Happonen, Lotta; Varjosalo, Markku; Malm, Tarja; Leinonen, Ville; Chroni, Angeliki; Saavalainen, Päivi; Meri, Seppo; Kajander, Tommi; Wollman, Adam JM; Nissilä, Eija; Haapasalo, Karita. 2023. Embo reports. 24: -
Serum Cathepsin S Levels Do Not Show Alterations in Different Clinical, Neuropathological, or Genetic Subtypes of Frontotemporal Dementia Patients nor in Comparison to Healthy Control Individuals
Heikkinen, Sami; Huber, Nadine; Katisko, Kasper; Kokkola, Tarja; Hartikainen, Päivi; Krüger, Johanna; Leinonen, Ville; Korhonen, Ville E; Herukka, Sanna-Kaisa; Remes, Anne M; Borroni, Barbara; Alberici, Antonella; Libri, Ilenia; Solje, Eino; Haapasalo, Annakaisa. 2023. Journal of Alzheimer's disease. 93: 395-401 -
Cerebrospinal fluid biomarkers that reflect clinical symptoms in idiopathic normal pressure hydrocephalus patients
Lukkarinen, Heikki; Jeppsson, Anna; Wikkelsö, Carsten; Blennow, Kaj; Zetterberg, Henrik; Constantinescu, Radu; Remes, Anne M.; Herukka, Sanna-Kaisa; Hiltunen, Mikko; Rauramaa, Tuomas; Nägga, Katarina; Leinonen, Ville; Tullberg, Mats. 2022. Fluids and barriers of the cns. 19: . 11 -
Computer-based Eye-tracking Analysis of King-Devick Test Differentiates Persons With Idiopathic Normal Pressure Hydrocephalus From Cognitively Unimpaired
Lehtola, Juha-Matti; Kärkkäinen, Virve; Andberg, Sami; Hannonen, Sanna; Rusanen, Minna; Saari, Toni; Korhonen, Ville; Hokkanen, Laura; Hallikainen, Merja; Hänninen, Tuomo; Kaarniranta, Kai; Bednarik, Roman; Leinonen, Ville; Koivisto, Anne M. 2022. Alzheimer disease and associated disorders. 36: 340-346 -
Editorial: Toward a better understanding of the pathophysiology and clinical management of idiopathic normal pressure hydrocephalus
Karagiozov, Kostadin L.; Leinonen, Ville; Miyajima, Masakazu; Nakajima, Madoka. 2022. Frontiers in neurology. 13: . 1013720 -
Genome-wide meta-analysis for Alzheimer’s disease cerebrospinal fluid biomarkers
Jansen, Iris E.; van der Lee, Sven J.; Gomez-Fonseca, Duber; de Rojas, Itziar; Dalmasso, Maria Carolina; Grenier-Boley, Benjamin; Zettergren, Anna; Mishra, Aniket; Ali, Muhammad; Andrade, Victor; Bellenguez, Céline; Kleineidam, Luca; Küçükali, Fahri; Sung, Yun Ju; Tesí, Niccolo; Vromen, Ellen M.; Wightman, Douglas P.; Alcolea, Daniel; Alegret, Montserrat; Alvarez, Ignacio; Amouyel, Philippe; Athanasiu, Lavinia; Bahrami, Shahram; Bailly, Henri; Belbin, Olivia; Bergh, Sverre; Bertram, Lars; Biesse. 2022. Acta neuropathologica. 144: 821-842 -
In vivo assessment of Lewy body and beta-amyloid copathologies in idiopathic normal pressure hydrocephalus: prevalence and associations with clinical features and surgery outcome
Giannini, Giulia; Baiardi, Simone; Dellavalle, Sofia; Zenesini, Corrado; Cevoli, Sabina; Danner, Nils; Jyrkkänen, Henna-Kaisa; Rossi, Marcello; Polischi, Barbara; Quadalti, Corinne; Stefanini, Camilla; Cortelli, Pietro; Milletti, David; Herukka, Sanna-Kaisa; Palandri, Giorgio; Leinonen, Ville; Parchi, Piero. 2022. Fluids and barriers of the cns. 19: . 71 -
Incidence and risk factors of spinal cord stimulation for persistent or recurrent pain after lumbar spine surgery: a population-based study
Huttunen, Jukka; Fraunberg, Mikael von und zu; Ikäheimo, Tiina-Mari; Jyrkkänen, Henna-Kaisa; Nissen, Mette; Leinonen, Ville; Salmenkivi, Jyrki; Malmivaara, Antti; Sirola, Joonas; Sund, Reijo. 2022. Acta neurochirurgica. 164: 2645-2653 -
Kaularangan luisen juuriaukkoahtauman kirurginen hoito
Kotkansalo, Anna; Leinonen, Ville; Korhonen, Katariina; Rinne, Jaakko; Malmivaara, Antti . 2022. Duodecim. 138: 769-777 -
Neuropathological findings in possible normal pressure hydrocephalus: A post-mortem study of 29 cases with lifelines
Hänninen, JJ; Nakajima, M; Vanninen, A; Hytönen, S; Rummukainen, J; Koivisto, AM; Jääskeläinen, JE; Soininen, H; Sutela, A; Vanninen, R; Hiltunen, M; Leinonen, V; Rauramaa, T. 2022. Free neuropathology. 3: 1-17 -
Postural sway does not differentiate individuals with chronic low back pain, single and multisite chronic musculoskeletal pain, or pain-free controls: a cross-sectional study of 229 subjects
Mikkonen, Jani; Leinonen, Ville; Kaski, Diego; Hartvigsen, Jan; Luomajoki, Hannu; Selander, Tuomas; Airaksinen, Olavi. 2022. Spine journal. 22: 1523-1534 -
Serum total TDP-43 levels are decreased in frontotemporal dementia patients with C9orf72 repeat expansion or concomitant motoneuron disease phenotype
Katisko, Kasper; Huber, Nadine; Kokkola, Tarja; Hartikainen, Päivi; Krüger, Johanna; Heikkinen, Anna-Leena; Paananen, Veera; Leinonen, Ville; Korhonen, Ville E.; Helisalmi, Seppo; Herukka, Sanna-Kaisa; Cantoni, Valentina; Gadola, Yasmine; Archetti, Silvana; Remes, Anne M.; Haapasalo, Annakaisa; Borroni, Barbara; Solje, Eino. 2022. Alzheimer's research and therapy. 14: . 151 -
Shortening of Saccades as a Possible Easy-to-Use Biomarker to Detect Risk of Alzheimer’s Disease
Hannonen, Sanna; Andberg, Sami; Kärkkäinen, Virve; Rusanen, Minna; Lehtola, Juha-Matti; Saari, Toni; Korhonen, Ville; Hokkanen, Laura; Hallikainen, Merja; Hänninen, Tuomo; Leinonen, Ville; Kaarniranta, Kai; Bednarik, Roman; Koivisto, Anne M.. 2022. Journal of Alzheimer's disease. 88: 609-618 -
The effect of antithrombotic therapy on the recurrence and outcome of chronic subdural hematoma after burr-hole craniostomy in a population-based cohort
Kerttula, Santtu; Huttunen, Jukka; Leinonen, Ville; Kämäräinen, Olli Pekka; Danner, Nils. 2022. Acta neurochirurgica. 164: 2699-2708 -
The effect of shunt surgery on corticospinal excitability in idiopathic normal pressure hydrocephalus: a transcranial magnetic stimulation study
Sirkka, Jani; Säisänen, Laura; Julkunen, Petro; Könönen, Mervi; Kallioniemi, Elisa; Leinonen, Ville; Danner, Nils. 2022. Fluids and barriers of the cns. 19: . 89 -
5-Year health-related quality of life outcome in patients with idiopathic normal pressure hydrocephalus
Junkkari, A; Sintonen, H; Danner, N; Jyrkkänen, HK; Rauramaa, T; Luikku, AJ; Koivisto, AM; Roine, RP; Viinamäki, H; Soininen, H; Jääskeläinen, JE; Leinonen, V. 2021. Journal of neurology. 268: 3283-3293 -
A Novel Genetic Marker for the C9orf72 Repeat Expansion in the Finnish Population
Rostalski, H; Korhonen, V; Kuulasmaa, T; Solje, E; Krüger, J; Gen, F; Kaivola, K; Eide, PK; Lambert, JC; Julkunen, V; Tienari, PJ; Remes, AM; Leinonen, V; Hiltunen, M; Haapasalo, A. 2021. Journal of Alzheimer's disease. 83: 1325-1332 -
Alzheimerin taudin uudet riskigeenit - keskiössä mikrogliasolut
Martiskainen, Henna; Takalo, Mari; Konttinen, Henna; Malm, Tarja; Haapasalo, Annakaisa; Leinonen, Ville; Hiltunen, Mikko. 2021. Duodecim. 137: 1375- 1382 -
Cerebrospinal fluid dynamics in idiopathic intracranial hypertension: a literature review and validation of contemporary findings
Kaipainen, Aku L; Martoma, Erik; Puustinen, Tero; Tervonen, Joona; Jyrkkänen, Henna-Kaisa; Paterno, Jussi J; Kotkansalo, Anna; Rantala, Susanna; Vanhanen, Ulla; Leinonen, Ville; Lehto, Soili M; Iso-Mustajärvi, Matti; Elomaa, Antti-Pekka; Qvarlander, Sara; Huuskonen, Terhi J. 2021. Acta neurochirurgica. 163: 3353-3368 -
Cross-Cultural Adaptation, Reliability, and Psychophysical Validation of the Pain and Sleep Questionnaire Three-Item Index in Finnish
Mikkonen, Jani; Leinonen, Ville; Luomajoki, Hannu; Kaski, Diego; Kupari, Saana; Tarvainen, Mika; Selander, Tuomas; Airaksinen, Olavi. 2021. Journal of clinical medicine. 10: 4887 -
Cross-cultural adaptation and validation of the Finnish version of the central sensitization inventory and its relationship with dizziness and postural control
Mikkonen, Jani; Luomajoki, Hannu; Airaksinen, Olavi; Neblett, Randy; Selander, Tuomas; Leinonen, Ville. 2021. Bmc neurology. 21: 141 -
Elevated CSF LRG and Decreased Alzheimer's Disease Biomarkers in Idiopathic Normal Pressure Hydrocephalus
Vanninen, Aleksi; Nakajima, Madoka; Miyajima, Masakazu; Rauramaa, Tuomas; Kokki, Merja; Musialowicz, Tadeusz; Mäkinen, Petra M; Herukka, Sanna-Kaisa; Koivisto, Anne M; Jääskeläinen, Juha E; Hiltunen, Mikko; Leinonen, Ville. 2021. Journal of clinical medicine. 10: 1105 -
Ex Vivo Porcine Models Are Valid for Testing and Training Microsurgical Lumbar Decompression Techniques
Säteri, Tuomas; Nurro, Jussi; Hätinen, Olli-Pekka; Hakulinen, Mikko; Leinonen, Ville; Elomaa, Antti-Pekka. 2021. World neurosurgery. 155: e64-e74 -
FTLD Patient-Derived Fibroblasts Show Defective Mitochondrial Function and Accumulation of p62
Leskelä, S; Hoffmann, D; Rostalski, H; Huber, N; Wittrahm, R; Hartikainen, P; Korhonen, V; Leinonen, V; Hiltunen, M; Solje, E; Remes, AM; Haapasalo, A. 2021. Molecular neurobiology. 58: 5438-5458 -
Functional Characterization of Human Pluripotent Stem Cell-Derived Models of the Brain with Microelectrode Arrays
Pelkonen, Anssi; Pistono, Cristiana; Klecki, Pamela; Gómez-Budia, Mireia; Dougalis, Antonios; Konttinen, Henna; Stanová, Iveta; Fagerlund, Ilkka; Leinonen, Ville; Korhonen, Paula; Malm, Tarja. 2021. Cells. 2022; 11: 106 -
Gabapentinoids Associated With Lower Explantation Rate in 203 Patients With Spinal Cord Stimulation for Failed Back Surgery Syndrome
Nissen, Mette; Ikäheimo, Tiina-Mari; Huttunen, Jukka; Leinonen, Ville; Jyrkkänen, Henna-Kaisa; von und zu Fraunberg, Mikael. 2021. Neurosurgery. 89: 626-634 -
MECP2 Increases the Pro-Inflammatory Response of Microglial Cells and Phosphorylation at Serine 423 Regulates Neuronal Gene Expression upon Neuroinflammation
Wittrahm, Rebekka; Takalo, Mari; Marttinen, Mikael; Kuulasmaa, Teemu; Mäkinen, Petra; Kemppainen, Susanna; Martiskainen, Henna; Rauramaa, Tuomas; Pike, Ian; Leinonen, Ville; Natunen, Teemu; Haapasalo, Annakaisa; Hiltunen, Mikko. 2021. Cells. 10: 860 -
Plasma miR-9-3p and miR-136-3p as Potential Novel Diagnostic Biomarkers for Experimental and Human Mild Traumatic Brain Injury
Das Gupta, Shalini; Ciszek, Robert; Heiskanen, Mette; Lapinlampi, Niina; Kukkonen, Janne; Leinonen, Ville; Puhakka, Noora; Pitkänen, Asla. 2021. International journal of molecular sciences. 22: 1563 -
Preoperative measurements on MRI in Chiari 1 patients fail to predict outcome after decompressive surgery
Jussila, Miro-Pekka; Nissilä, Juho; Vakkuri, Minna; Olsén, Päivi; Niinimäki, Jaakko; Leinonen, Ville; Serlo, Willy; Salokorpi, Niina; Suo-Palosaari, Maria. 2021. Acta neurochirurgica. [Epub ahead of print 11 May 2021]: 1-10 -
S327 phosphorylation of the presynaptic protein SEPTIN5 increases in the early stages of neurofibrillary pathology and alters the functionality of SEPTIN5
Ferreira, Catarina B.; Marttinen, Mikael; Coelho, Joana E.; Paldanius, Kaisa M.A.; Takalo, Mari; Mäkinen, Petra; Leppänen, Luukas; Miranda-Lourenço, Catarina; Fonseca-Gomes, João; Tanqueiro, Sara R.; Vaz, Sandra H.; Belo, Rita F.; Sebastião, Ana Maria; Leinonen, Ville; Soininen, Hilkka; Pike, Ian; Haapasalo, Annakaisa; Lopes, Luísa V.; de Mendonça, Alexandre; Diógenes, Maria José; Hiltunen, Mikko. 2021. Neurobiology of disease. 2022; 163: 105603 -
Shunt performance in 349 patients with hydrocephalus after aneurysmal subarachnoid hemorrhage
Tervonen, Joona; Adams, Hadie; Lindgren, Antti; Elomaa, Antti-Pekka; Kämäräinen, Olli-Pekka; Kärkkäinen, Virve; von und zu Fraunberg, Mikael; Huttunen, Jukka; Koivisto, Timo; Jääskeläinen, Juha E.; Leinonen, Ville; Huuskonen, Terhi J.. 2021. Acta neurochirurgica. 163: 2703-2714 -
Surgically treated C1 fractures: a population-based study
Ylönen, Henri; Danner, Nils; Jyrkkänen, Henna-Kaisa; Kämäräinen, Olli-Pekka; Leinonen, Ville; Huttunen, Jukka. 2021. World neurosurgery. 154: e333-e342 -
The CERAD Neuropsychological Battery in Patients with Idiopathic Normal Pressure Hydrocephalus Compared with Normal Population and Patients with Mild Alzheimer's Disease
Nerg, Ossi; Junkkari, Antti; Hallikainen, Ilona; Rauramaa, Tuomas; Luikku, Antti; Hiltunen, Mikko; Jääskeläinen, Juha E.; Leinonen, Ville; Hänninen, Tuomo; Koivisto, Anne;. 2021. Journal of Alzheimer's disease. 81: 1117-1130 -
Time Trends of Cerebrospinal Fluid Biomarkers of Neurodegeneration in Idiopathic Normal Pressure Hydrocephalus
Lukkarinen, Heikki; Tesseur, Ina; Pemberton, Darrel; Van Der Ark, Peter; Timmers, Maarten; Slemmon, Randy; Janssens, Luc; Streffer, Johannes; Van Nueten, Luc; Bottelbergs, Astrid; Rauramaa, Tuomas; Koivisto, Anne M.; Herukka, Sanna-Kaisa; Korhonen, Ville E.; Junkkari, Antti; Hiltunen, Mikko; Engelborghs, Sebastiaan; Blennowk, Kaj; Zetterbergk, Henrik; Kolb, Hartmuth C.; Leinonen, Ville. 2021. Journal of Alzheimer's disease. 80: 1629-1642 -
Upper limb dysfunction and activities in daily living in idiopathic normal pressure hydrocephalus
Sirkka, Jani; Parviainen, Marita; Jyrkkänen, Henna-Kaisa; Koivisto, Anne M.; Säisänen, Laura; Rauramaa, Tuomas; Leinonen, Ville; Danner, Nils. 2021. Acta neurochirurgica. 163: 2675-2683 -
iNPH - the mystery resolving
Leinonen, Ville; Kuulasmaa, Teemu; Hiltunen, Mikko. 2021. Embo molecular medicine. 13: e13720 -
Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-ß from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy
Carare, RO; Aldea, R; Agarwal, N; Bacskai, BJ; Bechman, I; Boche, D; Bu, G; Bulters, D; Clemens, A; Counts, SE; de Leon, M; Eide, PK; Fossati, S; Greenberg, SM; Hamel, E; Hawkes, CA; Koronyo-Hamaoui, M; Hainsworth, AH; Holtzman, D; Ihara, M; et al [incl. Kanninen, K; Leinonen, V; Malm, T]. 2020. Alzheimer's & dementia : diagnosis, assessment & disease monitoring. 21: e12053 -
Corticospinal Excitability in Idiopathic Normal Pressure Hydrocephalus: A Transcranial Magnetic Stimulation Study
Sirkka, J; Säisänen, L; Julkunen, P; Könönen, M; Kallioniemi, E; Leinonen, V; Danner, N. 2020. Fluids and barriers of the cns. 17: 6 -
Diabetes is associated with familial idiopathic normal pressure hydrocephalus: a case-control comparison with family members
Räsänen, Joel; Huovinen, Joel; Korhonen, Ville E; Junkkari, Antti; Kastinen, Sami; Komulainen, Simo; Oinas, Minna; Avellan, Cecilia; Frantzen, Janek; Rinne, Jaakko; Ronkainen, Antti; Kauppinen, Mikko; Lönnrot, Kimmo; Perola, Markus; Koivisto, Anne M; Remes, Anne M; Soininen, Hilkka; Hiltunen, Mikko; Helisalmi, Seppo; Kurki, Mitja I [et al. incl. Jääskeläinen, Juha E: Leinonen, Ville]. 2020. Fluids and barriers of the cns. 17: 57 -
Diabetic phenotype in mouse and humans reduces the number of microglia around ß-amyloid plaques
Natunen, Teemu; Martiskainen, Henna; Marttinen, Mikael; Gabbouj, Sami; Koivisto, Hennariikka; Kemppainen, Susanna; Kaipainen, Satu; Takalo, Mari; Svobodová, Helena; Leppänen, Luukas; Kemiläinen, Benjam; Ryhänen, Simo; Kuulasmaa, Teemu: Rahunen, Eija: Juutinen, Sisko; Mäkinen, Petra; Miettinen, Pasi; Rauramaa, Tuomas; Pihlajamäki, Jussi; Haapasalo, Annakaisa; et al [incl. Leinonen, Ville; Tanila, Heikki; Hiltunen, Mikko]. 2020. Molecular neurodegeneration. 15: 66 -
Finnish Study of Intraoperative Irrigation Versus Drain Alone After Evacuation of Chronic Subdural Haematoma (FINISH): A Study Protocol for a Multicentre Randomised Controlled Trial
Tommiska, P; Raj, R; Schwartz, C; Kivisaari, R; Luostarinen, T; Satopää, J; Taimela, S; Järvinen, T; Ranstam, J; Frantzen, J; Posti, J; Luoto, TM; Leinonen, V; Tetri, S; Koivisto, T; Lönnrot, K. 2020. BMJ open. 10: e038275 -
Higher Preimplantation Opioid Doses Associated With Long-Term Spinal Cord Stimulation Failure in 211 Patients With Failed Back Surgery Syndrome
Nissen, Mette; Ikäheimo, Tiina-Mari; Huttunen, Jukka; Leinonen, Ville; Jyrkkänen, Henna-Kaisa; von Und Zu Fraunberg, Mikael. 2020. Neuromodulation. 2021; 24: 102-111 -
LifeTime and improving European healthcare through cell-based interceptive medicine
Rajewsky, Nikolaus; Almouzni, Geneviève; Gorski, Stanislaw A; Aerts, Stein; Amit, Ido; Bertero, Michela G; Bock, Christoph; Bredenoord, Annelien L; Cavalli, Giacomo; Chiocca, Susanna; Clevers, Hans; Strooper, Bart De; Eggert, Angelika; Ellenberg, Jan; Fernández, Xosé M; Figlerowicz, Marek; Gasser, Susan M; Hubner, Norbert; Kjems, Jørgen; Knoblich, Jürgen A et al. [incl. Pitkänen, Asla; Leinonen, Ville]. 2020. Nature. 587: 377-386 -
Occurrence, Risk Factors, and Time Trends for Late Reoperations due to Degenerative Cervical Spine Disease: A Finnish National Register Study of 19 377 Patients Operated on Between 1999 and 2015
Kotkansalo, Anna; Leinonen, Ville; Korajoki, Merja; Korhonen, Katariina; Rinne, Jaakko; Malmivaara, Antti. 2020. Neurosurgery. 2021; 88: 558-573 -
PTPR type Q in cerebrospinal fluid reflects ependymal cells dysfunction and is a potential biomarker for adult chronic hydrocephalus
Nakajima, Madoka; Rauramaa, Tuomas; Mäkinen, Petra M; Hiltunen, Mikko; Herukka, Sanna-Kaisa; Kokki, Merja; Musialowicz, Tadeusz; Jyrkkänen, Henna-Kaisa; Danner, Nils; Junkkari, Antti; Koivisto, Anne M; Jääskeläinen, Juha E; Miyajima, Masakazu; Ogino, Ikuko; Furuta, Akiko; Akiba, Chihiro; Kawamura, Kaito; Kamohara, Chihiro; Sugano, Hidenori; Tange, Yuichi; et al. [incl. Leinonen, Ville]. 2020. European journal of neurology. 2021; 28: 389-400 -
Preoperative Predictors of Better Long-Term Functional Ability and Decreased Pain Following LSS Surgery: A Prospective Observational Study with a 10-year Follow-Up Period
Tuomainen, I; Pesonen, J; Rade, M; Pakarinen, M; Leinonen, V; Kröger, H; Airaksinen, O; Aalto, T. 2020. Spine. 45: 776-783 -
Presynaptic Vesicle Protein SEPTIN5 Regulates the Degradation of APP C-Terminal Fragments and the Levels of Aß
Marttinen, Mikael; Ferreira, Catarina B; Paldanius, Kaisa M A; Takalo, Mari; Natunen, Teemu; Mäkinen, Petra; Leppänen, Luukas; Leinonen, Ville; Tanigaki, Kenji; Kang, Gina; Hiroi, Noboru; Soininen, Hilkka; Rilla, Kirsi; Haapasalo, Annakaisa; Hiltunen, Mikko. 2020. Cells. 9: 2482 -
Unfolding the outcomes of surgical treatment of lumbar spinal stenosis-a prospective 5- and 10-year follow-up study
Tuomainen, I; Aalto, T; Pesonen, J; Rade, M; Pakarinen, M; Leinonen, V; Kröger, H; Airaksinen, O. 2020. European spine journal. 29: 2231-2242 -
Aivovammat
Luoto, Teemu; Leinonen, Ville; Bendel, Stepani; Koivisto, Timo; Jääskeläinen, Juha E. Teoksessa: Leppäniemi, Ari; Kuokkanen, Hannu; Salminen, Pauliina(toim.) , 2019. Kirurgia. s. 892-905. Kustannus Oy Duodecim -
CSF biomarkers distinguish idiopathic normal pressure hydrocephalus from its mimics
Jeppsson, Anna; Wikkelsö, Carsten; Blennow, Kaj; Zetterberg, Henrik; Constantinescu, Radu; Remes, Anne M; Herukka, Sanna-Kaisa; Rauramaa, Tuomas; Nagga, Katarina; Leinonen, Ville; Tullberg, Mats. 2019. Journal of neurology neurosurgery and psychiatry. 90: 1117-1123 -
Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology: A Systematic Review and Meta-analysis
Bridel, C; van Wieringen, WN; Zetterberg, H; Tijms, BM; Teunissen, CE; Alvarez-Cermeño, JC; Andreasson, U; Axelsson, M; Bäckström, DC; Bartos, A; Bjerke, M; Blennow, K; Boxer, A; Brundin, L; Burman, J; Christensen, T; Fialová, L; Forsgren, L; Frederiksen, JL; Gisslén, M; et al.; and the NFL Group (incl. Leinonen, V). 2019. JAMA neurology. 76: 1035-1048 -
Finnish Trial on Practices of Anterior Cervical Decompression and Fusion (FACADE): a protocol for a prospective randomised non-inferiority trial comparing outpatient versus inpatient care
Lönnrot, Kimmo; Taimela, Simo; Toivonen, Pirjo; Aronen, Pasi; Koski-Palken, Anniina; Frantzen, Janek; Leinonen, Ville; Silvasti-Lundell, Marja; Förster, Johannes; Jarvinen, Teppo. 2019. BMJ open. 9: 1-8 -
MIM-Deficient Mice Exhibit Anatomical Changes in Dendritic Spines, Cortex Volume and Brain Ventricles, and Functional Changes in Motor Coordination and Learning
Minkeviciene R, Hlushchenko, I; Virenque, A; Lahti, L; Khanal, P; Rauramaa, T; Koistinen, A; Leinonen, V; Noe, FM; Hotulainen, P. 2019. Frontiers in molecular neuroscience. 12: 276 -
Normaalipaineisen hydrokefaluksen kliininen kuva, diagnostiset tutkimukset ja hoito
Leinonen, Ville; Junkkari, Antti; Rauramaa, Tuomas; Jääskeläinen, Juha E; Vanninen, Ritva; Savolainen, Sakari; Hiltunen, Mikko; Remes, Anne M; Koivisto, Anne M. 2019. Duodecim. 135: 265-273 -
Predicting Development of Alzheimer's Disease in Patients with Shunted Idiopathic Normal Pressure Hydrocephalus
Luikku, AJ; Hall, A; Nerg, O; Koivisto, AM; Hiltunen, M; Helisalmi, S; Herukka, SK; Junkkari, A; Sutela, A; Kojoukhova, M; Korhonen, V; Mattila, J; Lötjönen, J; Rummukainen, J; Alafuzoff, I; Jääskeläinen, JE; Remes, AM; Solomon, A; Kivipelto, M; Soininen, H; et al. [Incl. Rauramaa, T; Leinonen, V]. 2019. Journal of Alzheimer's disease. 71: 1233-1243 -
Prevalence of C9ORF72 Expansion in a Large Series of Patients with Idiopathic Normal-Pressure Hydrocephalus
Korhonen, VE; Remes, AM; Helisalmi, S; Rauramaa, T; Sutela, A; Vanninen, R; Suhonen, NM; Haapasalo, A; Hiltunen, M; Jääskeläinen, JE; Soininen, H; Koivisto, AM; Leinonen, V. 2019. Dementia and geriatric cognitive disorders. 47: 91-103 -
Psychiatric disorders are a common prognostic marker for worse outcome in patients with idiopathic intracranial hypertension
Puustinen, Tero; Tervonen, Joona; Avellan, Cecilia; Jyrkkänen, Henna-Kaisa; Paterno, Jussi J; Hartikainen, Päivi; Vanhanen, Ulla; Leinonen, Ville; Lehto, Soili M; Elomaa, Antti-Pekka; Huttunen, Terhi J. 2019. Clinical neurology and neurosurgery. 186: 105527 -
Surgery for degenerative cervical spine disease in Finland, 1999-2015
Kotkansalo, A; Leinonen, V; Korajoki, M; Salmenkivi, J; Korhonen, K; Malmivaara, A. 2019. Acta neurochirurgica. 161: 2147-2159 -
Surgical techniques for degenerative cervical spine in Finland from 1999 to 2015
Kotkansalo, A; Malmivaara, A; Korajoki, M; Korhonen, K; Leinonen, V. 2019. Acta neurochirurgica. 161: 2161-2173 -
The Kuopio idiopathic normal pressure hydrocephalus protocol: initial outcome of 175 patients
Junkkari, A; Luikku, A J; Danner, N; Jyrkkänen, H K; Rauramaa, T; Korhonen, V E; Koivisto, A M; Nerg, O; Kojoukhova, M; Huttunen, T J; Jääskeläinen, J E; Leinonen, V. 2019. Fluids and barriers of the cns. 16: 21 -
[11C]PIB PET Is Associated with the Brain Biopsy Amyloid-ß Load in Subjects Examined for Normal Pressure Hydrocephalus
Rinne, JO; Suotunen, T; Rummukainen, J; Herukka, SK; Nerg, O; Koivisto, AM; Rauramaa, T; Någren, K; Hiltunen, M; Alafuzoff, I; Rinne, J; Jääskeläinen, JE; Soininen, H; Leinonen, V. 2019. Journal of Alzheimer's disease. 67: 1343-1351 -
Aikuisten hydrokefalus ja sunttikomplikaatiot
Jääskeläinen, Juha E; Leinonen, Ville. Teoksessa: Jousimaa, Jukkapekka; Alenius, Heidi; Atula, Sari; Berghem, Nora; Kattainen, Anna; Kunnamo, Ilkka; Pelttari, Hanna; Teikar, Martti(toim.) , 2018. Lääkärin käsikirja [online]. s. -. Kustannus Oy Duodecim -
Alterations in mitochondria-endoplasmic reticulum connectivity in human brain biopsies from idiopathic normal pressure hydrocephalus patients
Leal, NS; Dentoni, G; Schreiner, B; Kämäräinen, OP; Partanen, N; Herukka, SK; Koivisto, AM; Hiltunen, M; Rauramaa, T; Leinonen, V; Ankarcrona, M. 2018. Acta neuropathologica communications. 6: 102 -
Copy number loss in SFMBT1 is common among Finnish and Norwegian patients with iNPH
Korhonen, VE; Helisalmi, S; Jokinen, A; Jokinen, I; Lehtola, JM; Oinas, M; Lönnrot, K; Avellan, C; Kotkansalo, A; Frantzen, J; Rinne, J; Ronkainen, A; Kauppinen, M; Junkkari, A; Hiltunen, M; Soininen, H; Kurki, M; Jääskeläinen, JE; Koivisto, AM; Sato, H; et al. 2018. Neurology : Genetics. 4: e291 -
Ensihoidosta neurotehohoitoon
Leinonen, Ville; Kurola, Jouni; Lång, Maarit; Niemelä, Mika; Jääskeläinen, Juha E. Teoksessa: Leppäniemi, Ari; Kuokkanen, Hannu; Salminen, Pauliina(toim.) , 2018. Kirurgia. s. 882-885. Duodecim -
Incidence, comorbidities, and mortality in idiopathic normal pressure hydrocephalus
Pyykkö, OT; Nerg, O; Niskasaari, HM; Niskasaari, T; Koivisto, AM; Hiltunen, M; Pihlajamäki, J; Rauramaa, T; Kojoukhova, M; Alafuzoff, I; Soininen, H; Jääskeläinen, JE; Leinonen, V. 2018. World neurosurgery. 112: e624-e631 -
Interrelationship between the Levels of C9orf72 and Amyloid-ß Protein Precursor and Amyloid-ß in Human Cells and Brain Samples
Leskelä, S; Takalo, M; Marttinen, M; Huber, N; Paananen, J; Mitra, V; Rauramaa, T; Mäkinen, P; Leinonen, V; Soininen, H; Pike, I; Remes, AM; Hiltunen, M; Haapasalo, A. 2018. Journal of Alzheimer's disease. 62: 269-278 -
Keskushermoston neurokirurgisesti hoidettavat infektiot
Leinonen, Ville; Jääskeläinen, Juha E. Teoksessa: Leppäniemi, Ari; Kuokkanen, Hannu; Salminen, Pauliina(toim.) , 2018. Kirurgia. s. 954-955. Duodecim -
Keskushermoston toiminta ja häiriötilat
Kivipelto, Leena; Leinonen, Ville; Jääskeläinen, Juha E. Teoksessa: Leppäniemi, Ari; Kuokkanen, Hannu; Salminen, Pauliina(toim.) , 2018. Kirurgia. s. 876-879. Duodecim -
Likvorikierron häiriöt
Leinonen, Ville; Jääskeläinen, Juha E. Teoksessa: Leppäniemi, Ari; Kuokkanen, Hannu; Salminen, Pauliina(toim.) , 2018. Kirurgia. s. 955-959. Duodecim -
Long-Term Outcome of Spinal Cord Stimulation in Failed Back Surgery Syndrome: 20 Years of Experience With 224 Consecutive Patients
Nissen, Mette; Ikäheimo, Tiina-Mari; Huttunen, Jukka; Leinonen, Ville; von Und Zu Fraunberg, Mikael. 2018. Neurosurgery. 2019; 84: 1011-1018 -
Molecular Mechanisms of Synaptotoxicity and Neuroinflammation in Alzheimer's Disease
Marttinen, Mikael; Takalo, Mari; Natunen, Teemu; Wittrahm, Rebekka; Gabbouj, Sami; Kemppainen, Susanna; Leinonen, Ville; Tanila, Heikki; Haapasalo, Annakaisa; Hiltunen, Mikko. 2018. Frontiers in neurology. 12: 963 -
Neurokirurgia ja neurotautien yksilöllistetty hoito Suomessa
Niemelä, Mika; Leinonen, Ville; Koivisto, Timo; Kumpulainen, Timo; Öhman, Juha; Rinne, Jaakko; Jääskeläinen, Juha E. Teoksessa: Leppäniemi, Ari; Kuokkanen, Hannu; Salminen, Pauliina(toim.) , 2018. Kirurgia. s. 874-875. Duodecim -
Neurokirurgisesti hoidettavien tautien oireet ja kuvantaminen
Leinonen, Ville; Jääskeläinen, Juha E. Teoksessa: Leppäniemi, Ari; Kuokkanen, Hannu; Salminen, Pauliina(toim.) , 2018. Kirurgia. s. 880-882. Duodecim -
Prevalence of Schizophrenia in Idiopathic Normal Pressure Hydrocephalus
Vanhala, V; Junkkari, A; Korhonen, VE; Kurki, MI; Hiltunen, M; Rauramaa, T;, Nerg, O;, Koivisto, AM; Remes, AM; Perälä, J; Suvisaari, J; Lehto, S; Viinamäki, H; Soininen, H; Jääskeläinen, JE; Leinonen, V. 2018. Neurosurgery. 2019; 84: 883-889 -
Spinaalikanavan sairaudet
Leinonen, Ville; Jääskeläinen, Juha E. Teoksessa: Leppäniemi, Ari; Kuokkanen, Hannu; Salminen, Pauliina(toim.) , 2018. Kirurgia. s. 938-951. Duodecim -
Sushi repeat-containing protein X-Linked 2 - a novel phylogenetically conserved hypothalamo-pituitary protein
Anwer, M; Bolkvadze, T; Ndode-Ekane, XE; Puhakka, N; Rauramaa, T; Leinonen, V; van Vliet, EA; Swaab, DF; Haapasalo, A; Leskelä, S; Bister, N; Malm, T; Carlson, S; Aronica, E; Pitkänen, A. 2018. Journal of comparative neurology. 526: 1806-1819 -
Value stream map assessment of the extended day: 23h surgery model
Ruohoaho, Ulla-Maija; Kokki, Merja; Hirvonen, Jouni; Joukainen, Sarianna; Aaltomaa, Sirpa; von und zu Fraunberg, Mikael; Leinonen, Ville; Reijula, Jori. 2018. Intelligent buildings international. [Epub 21 MAR 2018]: - -
Alzheimer's Disease-Related Polymorphisms in Shunt-Responsive Idiopathic Normal Pressure Hydrocephalus
Huovinen J, Helisalmi S, Paananen J, Laiterä T, Kojoukhova M, Sutela A, Vanninen R, Laitinen M, Rauramaa T, Koivisto AM, Remes AM, Soininen H, Kurki M, Haapasalo A, Jääskeläinen JE, Hiltunen M, Leinonen V. 2017. Journal of Alzheimer's disease. 60: 1077-1085 -
Cerebrospinal fluid circulation and hydrocephalus
Leinonen V, Vanninen R, Rauramaa T. Teoksessa: Kovacs Gabor G, Alafuzoff Irina(toim.) , 2017. Handbook of Clinical Neurology. Neuropathology. s. 39-50. Elsevier -
Frontotemporal dementia as a comorbidity to idiopathic normal pressure hydrocephalus (iNPH): a short review of literature and an unusual case
Korhonen VE, Solje E, Suhonen NM, Rauramaa T, Vanninen R, Remes AM, Leinonen V. 2017. Fluids and barriers of the cns. 14: 10 -
Immunohistochemical Characterization and Sensitivity to Human Adenovirus Serotypes 3, 5, and 11p of New Cell Lines Derived from Human Diffuse Grade II to IV Gliomas
Niittykoski Minna, von und zu Fraunberg Mikael, Martikainen Miika, Rauramaa, Immonen Arto, Koponen Susanna, Leinonen Ville, Vähä-Koskela Markus, Zhang Qiwei, Kühnel Florian, Mei Ya-Fang, Ylä-Herttuala Seppo, Jääskeläinen Juha E, Hinkkanen Ari. 2017. Translational oncology. 10: 772-779 -
Niskakipu (aikuiset) : Käypä hoito -suositus (Päivitystiivistelmä)
Karppinen Jaro, Laimi Katri, Leinonen Ville, Malmivaara Antti, Niinimäki Jaakko, Airaksinen Olavi, Arokoski Jari, Auvinen Juha, Jääskeläinen Juhani, Martimo Kari-Pekka, Salo Petri, Soinne Lauri. 2017. Duodecim. 133: 699-700 -
Raised intracranial pressure and brain edema
Leinonen V, Vanninen R, Rauramaa T. Teoksessa: Kovacs Gabor G, Alafuzoff Irina(toim.) , 2017. Handbook of Clinical Neurology. Neuropathology. s. 25-37. Elsevier -
Rate and Risk Factors for Shunt Revision in Pediatric Patients with Hydrocephalus- A Population-Based Study
Tervonen Joona, Leinonen Ville, Jääskeläinen Juha E, Koponen Susanna, Huttunen Terhi J. 2017. World neurosurgery. 101: 615-622 -
Why does the health-related quality of life in idiopathic normal pressure hydrocephalus fail to improve despite the favorable clinical outcome?
Junkkari Antti, Roine Risto P, Luikku Antti, Rauramaa Tuomas, Sintonen Harri, Nerg Ossi, Koivisto Anne M, Häyrinen Antti, Viinamäki Heimo, Soininen Hilkka, Jääskeläinen Juha E, Leinonen Ville. 2017. World neurosurgery. 108: 356-366 -
Aneurysmal Subarachnoid Hemorrhage Patients' Risk Assessment for Shunting (aSAH-PARAS): An International Collaborative Study and Initiation of a Consortium
Adams H, Ban VS, Leinonen V, Aoun SG, Huttunen J, Saavalainen T, Lindgren A, Frosen J, Fraunberg M, Koivisto TS, Hernesniemi JA, Welch BG, Jääskeläinen J. 2016. Neurosurgery -
Associations of intracranial pressure with brain biopsy, radiological findings, and shunt surgery outcome in patients with suspected idiopathic normal pressure hydrocephalus
Kojoukhova Maria, Vanha Krista-Irina, Timonen Matti, Koivisto Anne M, Nerg Ossi, Rummukainen Jaana, Rauramaa Tuomas, Vanninen Ritva, Jääskeläinen Juha E, Sutela Anna, Leinonen Ville. 2016. Acta neurochirurgica. 2017; 159: 51-61 -
Effects of Alzheimer's Disease-Associated Risk Loci on Amyloid-ß Accumulation in the Brain of Idiopathic Normal Pressure Hydrocephalus Patients
Laiterä Tiina, Paananen Jussi, Helisalmi Seppo, Sarajärvi Timo, Huovinen Joel, Laitinen Marjo, Rauramaa Tuomas, Alafuzoff Irina, Remes Anne M, Soininen Hilkka, Haapasalo Annakaisa, Jääskeläinen Juha E, Leinonen Ville, Hiltunen Mikko. 2016. Journal of Alzheimer's disease. 2017; 55: 995-1003 -
Familial idiopathic normal pressure hydrocephalus
Huovinen J, Kastinen S, Komulainen S, Oinas M, Avellan C, Frantzen J, Rinne J, Ronkainen A, Kauppinen M, Lönnrot K, Perola M, Pyykkö OT, Koivisto AM, Remes AM, Soininen H, Hiltunen M, Helisalmi S, Kurki M, Jääskeläinen JE, Leinonen V. 2016. Journal of the neurological sciences. 368: 11-18 -
Health-related quality-of-life outcome in patients with idiopathic normal-pressure hydrocephalus - a 1-year follow-up study
Junkkari A, Häyrinen A, Rauramaa T, Sintonen H, Nerg O, Koivisto AM, Roine RP, Viinamäki H, Soininen H, Luikku A, Jääskeläinen JE, Leinonen V. 2016. European journal of neurology. 24: 58-66 -
High Risk of Dementia in Ventricular Enlargement with Normal Pressure Hydrocephalus Related Symptoms1
Koivisto Anne M, Kurki Mitja, Alafuzoff Irina, Sutela Anna, Rummukainen Jaana, Savolainen Sakari, Vanninen Ritva, Jääskeläinen Juha E, Soininen Hilkka, Leinonen Ville. 2016. Journal of Alzheimer's disease. 52: 497-507 -
Hätäkraniotomiat Pohjois-Karjalan keskussairaalassa vuosina 2006 - 2014
Aro Ellinoora, Jääskeläinen Juha E, Reinikainen Matti, Leinonen Ville, Hakala Tapio. 2016. Duodecim. 132: 858-65 -
Implantable RF-coil with multiple electrodes for long-term EEG-fMRI monitoring in rodents
Pirttimäki T, Salo RA, Shatillo A, Kettunen MI, Paasonen J, Sierra A, Jokivarsi K, Leinonen V, Andrade P, Quittek S, Pitkänen A, Gröhn O. 2016. Journal of neuroscience methods. 274: 154-163 -
Multimodal analysis to predict shunt surgery outcome of 284 patients with suspected idiopathic normal pressure hydrocephalus
Luikku Antti J, Hall Anette, Nerg Ossi, Koivisto Anne M, Hiltunen Mikko, Helisalmi Seppo, Herukka Sanna-Kaisa, Sutela Anna, Kojoukhova Maria, Mattila Jussi, Lötjönen Jyrki, Rummukainen Jaana, Alafuzoff Irina, Jääskeläinen Juha E, Remes Anne M, Soininen Hilkka, Leinonen Ville. 2016. Acta neurochirurgica. 158: 2311-2319 -
Risk of shunting after aneurysmal subarachnoid hemorrhage: a collaborative study and initiation of a consortium
Adams H, Ban VS, Leinonen V, Aoun SG, Huttunen J, Saavalainen T, Lindgren A, Frosen J, Fraunberg M, Koivisto T, Hernesniemi J, Welch BG, Jaaskelainen JE, Huttunen TJ. 2016. Stroke. 47: 2488-96 -
SEPT8 modulates ß-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1
Kurkinen Kaisa MA, Marttinen Mikael, Turner Laura, Natunen Teemu, Mäkinen Petra, Haapalinna Fanni, Sarajärvi Timo, Gabbouj Sami, Kurki Mitja, Paananen Jussi, Koivisto Anne M, Rauramaa Tuomas, Leinonen Ville, Tanila Hanila, Soininen Hilkka, Lucas Fiona R, Haapasalo Annakaisa, Hiltunen Mikko. 2016. Journal of cell science. 129: 2224-2238 -
Selling vs. non-selling neuro-oncology research cohorts and manuscripts in the eyes of a grumpy reviewer after 2,000 reviews
Leinonen Ville, Jääskeläinen Juha E. 2016. Acta neurochirurgica. 2017; 159: 3-6 -
Sub-classification based specific movement control exercises are superior to general exercise in sub-acute low back pain when both are combined with manual therapy: A randomized controlled trial
Lehtola Vesa, Luomajoki Hannu, Leinonen Ville, Gibbons Sean, Airaksinen Olavi. 2016. Bmc musculoskeletal disorders. 17: 135 -
Amyloid-ß and Tau Dynamics in Human Brain Interstitial Fluid in Patients with Suspected Normal Pressure Hydrocephalus
Herukka Sanna-Kaisa, Rummukainen Jaana, Ihalainen Jouni, von und zu Fraunberg Mikael, Koivisto Anne M, Nerg Ossi, Puli Lakshman K, Seppälä Toni T, Zetterberg Henrik, Pyykkö Okko T, Helisalmi Seppo, Tanila Heikki, Alafuzoff Irina, Hiltunen Mikko, Rinne Jaakko, Soininen Hilkka, Jääskeläinen Juha E, Leinonen Ville. 2015. Journal of Alzheimer's disease. 46: 261-269 -
Analysis of disruptive events and precarious situations caused by interaction with neurosurgical microscope
Eivazi Shahram, Afkari Hoorieh, Bednarik Roman, Leinonen Ville, Tukiainen Markku, Jääskeläinen Juha E. 2015. Acta neurochirurgica. 157: 1147-1154 -
Chasing the effects of pre-analytical confounders - a multicenter study on CSF-AD biomarkers
Leitão Maria João, Baldeiras Inês, Herukka Sanna-Kaisa, Pikkarainen Maria, Leinonen Ville, Simonsen Anja Hviid, Perret-Liaudet Armand, Fourier Anthony, Quadrio Isabelle, Veiga Pedro Mota, de Oliveira Catarina Resende. 2015. Frontiers in neurology. 6: 153 -
Effects of Alzheimer's Disease-Associated Risk Loci on Cerebrospinal Fluid Biomarkers and Disease Progression: A Polygenic Risk Score Approach
Martiskainen Henna, Helisalmi Seppo, Viswanathan Jayashree, Kurki Mitja, Hall Anette, Herukka Sanna-Kaisa, Sarajärvi Timo, Natunen Teemu, Kurkinen Kaisa M.A., Huovinen Jaakko, Mäkinen Petra, Laitinen Marjo, Koivisto Anne M., Mattila Kari M., Lehtimäki Terho, Remes Anne M., Leinonen Ville, Haapasalo Annakaisa, Soininen Hilkka, Hiltunen Mikko. 2015. Journal of Alzheimer's disease. 43: 565-573 -
Embedding an Eye Tracker into a Surgical Microscope: Requirements, Design, and Implementation
Eivazi Shahram, Bednarik R, Leinonen V, von und zu Fraunberg M, Jääskeläinen JE. 2015. IEEE sensors journal. 2016; 16: 2070-2078 -
Feasibility of radiological markers in idiopathic normal pressure hydrocephalus
Kojoukhova Maria, Koivisto Anne M, Korhonen Riiika, Remes Anne M, Vanninen Ritva, Soininen Hilkka, Jääskeläinen Juha E, Sutela Anna, Leinonen Ville. 2015. Acta neurochirurgica. 157: 1709-1719 -
Genetic Variation in delta-Opioid Receptor Associates with Increased ß- and gamma-Secretase Activity in the Late Stages of Alzheimer's Disease
Sarajärvi Timo, Marttinen Mikael, Natunen Teemu, Kauppinen Tarja, Mäkinen Petra, Helisalmi Seppo, Laitinen Marjo, Rauramaa Tuomas, Leinonen Ville, Petäjä-Repo Ulla, Soininen Hilkka, Haapasalo Annakaisa, Hiltunen Mikko. 2015. Journal of Alzheimer's disease. 48: 507-516 -
Health-related quality of life in patients with idiopathic normal pressure hydrocephalus
Junkkari A, Sintonen H, Nerg O, Koivisto AM, Roine RP, Viinamäki H, Soininen H, Jääskeläinen JE, Leinonen V. 2015. European journal of neurology. published online 24 JUN 2015: 9 p -
Normaalipaineinen hydrokefalia
Leinonen Ville, Koivisto Anne. Teoksessa: Timo Erkinjuntti, Anne Remes, Juha Rinne, Hilkka Soininen(toim.) , 2015. Muistisairaudet. s. 187-193. Kustannus Oy Duodecim -
Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models
Natunen Teemu, Takalo Mari, Kemppainen Ssusanna, Leskelä Stina, Marttinen Mikael, Kurkinen Kaisa MA, Pursiheimo Juha-Pekka, Sarajärvi Timo, Viswanathan Jayashree, Gabbouj Sami, Solje Eino, Tahvanainen Eveliina, Pirttimäki Tiina, Kurki Mitja, Paananen Jussi, Rauramaa Tuomas, Miettinen Pasi, Mäkinen Petra, Leinonen Ville, Soininen Hilkka et al. 2015. Neurobiology of disease. 2016; 85: 187-205 -
The Expression of Transthyretin and Amyloid-ß Protein Precursor is Altered in the Brain of Idiopathic Normal Pressure Hydrocephalus Patients
Laiterä Tiina, Kurki Mitja I, Pursiheimo Juha-Pekka, Zetterberg Henrik, Helisalmi Seppo, Rauramaa Tuomas, Alafuzoff Irina, Remes Anne M, Soininen Hilkka, Haapasalo Annakaisa, Jääskeläinen Juha E, Hiltunen Mikko, Leinonen Ville. 2015. Journal of Alzheimer's disease. 48: 959-968 -
The effect of decompressive surgery on lumbar paraspinal and biceps brachii muscle function and movement perception in lumbar spinal stenosis: a 2-year follow-up
Kääriäinen Tommi, Taimela Simo, Aalto Timo, Kröger Heikki, Herno Arto, Turunen Veli, Savolainen Sakari, Kankaanpää Markku, Airaksinen Olavi, Leinonen Ville. 2015. European spine journal. 2016; 25: 789-794 -
Alaselkäkipu: Käypä hoito -suositus
Pohjolainen T, Leinonen V, Frantzén J, Haanpää M, Jousimaa JP, Karppinen J, Kuukkanen T, Luoma K, Salmenkivi J, Österman H, Malmivaara A. 2014. Duodecim. hoi20001: artikkeli netissä -
Association between bone mineral density and lumbar disc degeneration
Salo Sami, Leinonen Ville, Rikkonen Tomi, Vainio Pauli, Marttila Jarkko, Honkanen Risto, Tuppurainen Marjo, Kröger Heikki, Sirola Joonas. 2014. Maturitas. S0378-5122: 00290-4 -
Cerebrospinal Fluid Biomarker and Brain Biopsy Findings in Idiopathic Normal Pressure Hydrocephalus
Pyykkö OT, Lumela M, Rummukainen J, Nerg O, Seppälä TT, Herukka SK, Koivisto AM, Alafuzoff I, Puli L, Savolainen S, Soininen H, Jääskeläinen JE, Hiltunen M, Zetterberg H, Leinonen V. 2014. PLoS ONE. 9: 1-10 -
Correlation of lateral stenosis in MRI with symptoms, walking capacity and EMG findings in patients with surgically confirmed lateral lumbar spinal canal stenosis
Kuittinen Pekka, Sipola Petri, Aalto Timo Juhani, Määttä Sara, Parviainen Anita, Saari Tapani, Sinikallio Sanna, Savolainen Sakari, Turunen Veli, Kröger Heikki, Airaksinen Olavi, Leinonen Ville. 2014. Bmc musculoskeletal disorders. 15: 247 -
Diagnostic effectiveness of quantitative [18F]flutemetamol PET imaging for detection of fibrillar amyloid ß using cortical biopsy histopathology as the standard of truth in subjects with idiopathic normal pressure hydrocephalus
Leinonen V, Rinne JO, Wong DF, Wolk DA, Trojanowski JQ, Sherwin PF, Smith A, Heurling K, Su M, Grachev ID. 2014. Acta neuropathologica communications. 2: 46 -
High-fat diet increases tau expression in the brain of T2DM and AD mice independently of peripheral metabolic status
Takalo M, Haapasalo A, Martiskainen H, Kurkinen KM, Koivisto H, Miettinen P, Khandelwal VK, Kemppainen S, Kaminska D, Mäkinen P, Leinonen V, Pihlajamäki J, Soininen H, Laakso M, Tanila H, Hiltunen M. 2014. Journal of nutritional biochemistry. 25: 634-641 -
Increased y-Secretase Activity in Idiopathic Normal Pressure Hydrocephalus Patients with b-Amyloid Pathology
Laiterä T, Sarajärvi T, Haapasalo A, Puli L, Kauppinen T, Mäkinen P, Rauramaa T, Tanila H, Jääskeläinen JE, Alafuzoff I, Soininen H, Leinonen V, Hiltunen M. 2014. PLoS ONE. 3: 1-8 -
Preoperative MRI Findings Predict Two-Year Postoperative Clinical Outcome in Lumbar Spinal Stenosis
Kuittinen P, Sipola P, Leinonen V, Saari T, Sinikallio S, Savolainen S, Kröger H, Turunen V, Airaksinen O, Aalto T. 2014. PLoS ONE. 9: e106404 -
Transcriptomics and mechanistic elucidation of Alzheimer's disease risk genes in the brain and in vitro models
Martiskainen H, Viswanathan J, Nykänen NP, Kurki M, Helisalmi S, Natunen T, Sarajärvi T, Kurkinen KM, Pursiheimo JP, Rauramaa T, Alafuzoff I, Jääskeläinen JE, Leinonen V, Soininen H, Haapasalo A, Huttunen HJ, Hiltunen M. 2014. Neurobiology of aging. 36: 1221.e15-1221.e28 -
Visually assessed severity of lumbar spinal canal stenosis is paradoxically associated with leg pain and objective walking ability
Kuittinen Pekka, Sipola Petri, Saari Tapani, Aalto Timo Juhani, Sinikallio Sanna, Savolainen Sakari, Kröger Heikki, Turunen Veli, Leinonen Ville, Airaksinen Olavi. 2014. Bmc musculoskeletal disorders. 15: 348 -
Association of Modic changes with health-related quality of life among patients referred to spine surgery
Määttä J, Kautiainen H, Leinonen V, Niinimäki J, Järvenpää S, Koskelainen T, Mäkelä P, Pesälä J, Nyyssönen T, Savolainen S, Airaksinen O, Kyllönen E, Cheung KMC, Karppinen J. 2013. Scandinavian journal of pain. Volume 5: 36-40 -
Content validity and responsiveness of a Finnish version of the Patient-Specific Functional Scale
Lehtola V, Kaksonen A, Luomajoki H, Leinonen V, Gibbons S, Airaksinen O. 2013. European journal of physiotherapy. 15: 134-138 -
Education of research ethics for clinical investigators with Moodle tool
Halkoaho A, Matveinen M, Leinonen V, Luoto K, Keränen T. 2013. Bmc medical ethics. 14: 53 -
Effects of NR1H3 genetic variation on the expression of liver X receptor alfa and the progression of Alzheimer's Disease
Natunen Teemu, Martiskainen Henna, Sarajärvi Timo, Helisalmi Seppo, Pursiheimo Juha-Pekka, Viswanathan Jayashree, Laitinen Marjo, Kauppinen Tarja, Rauramaa Tuomas, Leinonen Ville, Alafuzoff Irina, Haapasalo Annakaisa, Soininen Hilkka, Hiltunen Mikko. 2013. PLoS ONE. 8: e80700 -
Influence of comorbidities in idiopathic normal pressure hydrocephalus - research and clinical care. A report of the ISHCSF task force on comorbidities in INPH.
Malm J, Graff-Radford NR, Ishikawa M, Kristensen B, Leinonen V, Mori E, Owler BK, Tullberg M, Williams MA, Relkin NR. 2013. Fluids and barriers of the cns. 10: 22 -
Poor cognitive outcome in shunt-responsive idiopathic normal pressure hydrocephalus
Koivisto AM, Alafuzoff I, Savolainen S, Sutela A, Rummukainen J, Kurki M, Jääskeläinen JE, Soininen H, Rinne J, Leinonen V,. 2013. Neurosurgery. 72: 1-8 -
Positron emission tomography with [18F]flutemetamol and [11C]PiB for in vivo detection of cerebral cortical amyloid in normal pressure hydrocephalus patients
Leinonen V, Rinne JO, Virtanen KA, Eskola O, Rummukainen J, Huttunen J, von Und Zu Fraunberg M, Nerg O, Koivisto AM, Rinne J, Jääskeläinen JE, Buckley C, Smith A, Jones PA, Sherwin P, Farrar G, McLain R, Kailajärvi M, Heurling K, Grachev ID. 2013. European journal of neurology. 20: 1043-52 -
Prospective Flutemetamol Positron Emission Tomography and Histopathology in Normal Pressure Hydrocephalus
Rinne JO, Frantzen J, Leinonen V, Lonnrot K, Laakso A, Virtanen KA, Solin O, Kotkansalo A, Koivisto A, Sajanti J, Karppinen A, Lehto H, Rummukainen J, Buckley C, Smith A, Jones PA, Sherwin P, Farrar G, McLain R, Kailajarvi M, Grachev ID. 2013. Neurodegenerative diseases. epub ahead of print: 9 sivua -
APOE4 predicts amyloid-β in cortical brain biopsy but not idiopathic normal pressure hydrocephalus
Pyykkö OT, Helisalmi S, Koivisto AM, Mölsä JA, Rummukainen J, Nerg O, Alafuzoff I, Savolainen S, Soininen H, Jääskeläinen JE, Rinne J, Leinonen V, Hiltunen M. 2012. Journal of neurology neurosurgery and psychiatry. 83: 1119-1124 -
Accuracy and reproducibility of a retrospective outcome assessement for lumbar spinal stenosis surgery
Kuittinen P, Aalto T, Heikkilä T, Leinonen V, Savolainen S, Sipola P, Kröger H, Turunen V, Airaksinen O. 2012. Bmc musculoskeletal disorders. 13: 83 -
CSF biomarkers for Alzheimer disease correlate with cortical brain biopsy findings
Seppälä TT, Nerg O, Koivisto AM, Rummukainen J, Puli L, Zetterberg H, Pyykkö OT, Helisalmi S, Alafuzoff I, Hiltunen M, Jääskeläinen JE, Rinne J, Soininen H, Leinonen V, Herukka S-K. 2012. Neurology. 78: 1568-1575 -
Cortical brain biopsy in long-term prognostication of 468 patients with possible normal pressure hydrocephalus
Leinonen V, Koivisto AM, Alafuzoff I, Pyykkö OT, Rummukainen J, von Und Zu Fraunberg M, Jääskeläinen JE, Soininen H, Rinne J, Savolainen S. 2012. Neurodegenerative diseases. 10: 166-169 -
Efficacy of movement control exercises versus general exercises on recurrent sub-acute nonspecific low back pain in a sub-group of patients with movement control dysfunction. Protocol of a randomized controlled trial.
Lehtola V, Luomajoki H, Leinonen V, Gibbons S, Airaksinen O. 2012. Bmc musculoskeletal disorders. 13: 55: 1-9 -
Lumbar paraspinal and biceps brachii muscle function and movement perception in lumbar spinal stenosis
Kääriäinen T, Leinonen V, Taimela S, Aalto T, Kröger H, Herno A, Turunen V, Savolainen S, Kankaanpää M, Airaksinen O. 2012. European spine journal. 2012: 6 sivua -
Post-mortem findings in 10 patients with presumed normal-pressure hydrocephalus and review of the literature
Leinonen V, Koivisto AM, Savolainen S, Rummukainen J, Sutela A, Vanninen R, Jääskeläinen JE, Soininen H, Alafuzoff I. 2012. Neuropathology and applied neurobiology. 38: 72-86 -
Preoperative predictors for good postoperative satisfaction and functional outcome in lumbar spinal stenosis surgery - A prospective observational study with a two-year follow-up
Aalto T, Sinikallio S, Kröger H, Viinamäki H, Herno A, Leinonen V, Turunen V, Savolainen S, Airaksinen O. 2012. Scandinavian journal of surgery. 101: 255-260 -
[(18)F]Flutemetamol PET imaging and cortical biopsy histopathology for fibrillar amyloid β detection in living subjects with normal pressure hydrocephalus: pooled analysis of four studies
Rinne JO, Wong DF, Wolk DA, Leinonen V, Arnold SE, Buckley C, Smith A, McLain R, Sherwin PF, Farrar G, Kailajärvi M, Grachev ID. 2012. Acta neuropathologica. 124: 833-845 -
Amyloid-beeta and Hyperphospholated Tau in the Prediction of Azheimer's Disease
Rummukainen J, Koivisto AM, Alafuzoff I, Leinonen V. 2011. European neurological review. 6: 84-88 -
Cerebrospinal Fluid Biomarkers in Idiopathic Normal Pressure Hydrocephalus
Leinonen V, Menon LG, Carroll RS, Dello Iacono D, Grevet J, Jääskeläinen JE, Black PM. 2011. International journal of alzheimers disease. 2011: 1-6 -
Postoperative rehabilitation does not improve functional outcome in lumbar spinal stenosis: a prospective study with 2-year postoperative follow-up
Aalto, Timo J; Leinonen, Ville; Herno, Arto; Alen, Markku; Kröger, Heikki; Turunen, Veli; Savolainen, Sakari; Saari, Tapani; Airaksinen, Olavi. 2011. European spine journal. 20: 1331-1340 -
Visual and quantitative assessment of lateral lumbar spinal canal stenosis with magnetic resonance imaging
Sipola P, Leinonen V, Niemeläinen R, Aalto T, Vanninen R, Manninen H, Airaksinen O, Battié MC. 2011. Acta radiologica. 52: 1024-1031 -
Muistisairaudet
Erkinjuntti T, Rinne J & Soininen H. 2010. . . WS Bookwell Oy -
Assessment of beta-amyloid in a frontal cortical brain biopsy specimen and by positron emission tomography with carbon 11- labeled Pittsburgh compound B
Leinonen V, Alafuzoff I, Aalto S, Suotunen T, Savolainen S, Någren K, Tapiola T, Pirttilä T, Rinne J, Jääskeläinen JE, Soininen H, Rinne J, Pirttilä T, Soininen H. 2008. Archives of neurology. 65: 1304-1309 -
The amyloid beta-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae
Hansson Petersen CA, Alikhani N, Behbahani H, Wiehanger B, Pavlov PV, Alafuzoff I, Leinonen V, Ito A, Winbland B, Glaser E, Ankarcrona M. 2008. Proceedings of the National Academy of Sciences of the United States of America. 105: 13145-13150 -
Postural control in male patients with hip osteoarthritis
Arokoski JPA, Leinonen V, Arokoski MH, Aalto H, Valtonen H. 2006. Gait and posture. 23: 45-50 -
Back and neck extensor loading and back pain provocation in urban bus drivers with and without low back pain
Leinonen V, Kankaanpää M, Vanharanta H, Airaksinen O, Hänninen O. 2005. Pathophysiology. 12: 249-55 -
Indigenous healers' explanations of low back pain and its relief
Räsänen V, Leinonen V, Zaproudina N. 2005. Pathophysiology. 12: 313-316 -
Wireless on-line electromyography in recording neck muscle function: A pilot study
Airaksinen MK, Kankaanpää M, Aranko O, Leinonen V, Arokoski JPA, Airaksinen O. 2005. Pathophysiology. 12: 303-306 -
Lumbar paraspinal muscle function, perception of lumbar postition, and postural control in disc herniation-releted back pain
Leinonen V, Kankaanpää M, Luukonen M, Kansanen M, Hänninen O, Airaksinen O, Taimela S. 2003. Spine. 28: 842-848 -
Neuromuscular Control in Lumbar Disorders
Leinonen V. 2003. Kuopio University Publications D. Medical Sciences -
Paraspinal muscle denervation, paradoxically good lumbar endurance, and an abnormal flexion-extension cycle in lumbar spinal stenosis
Leinonen V, Määttä S, Taimela S, Herno A, Kankaanpää M, Partanen J, Hänninen O, Airaksinen O. 2003. Spine. 28: 324-331 -
Impaired lumbar movement perception in association with postural stability and motor- and somatosensory-evoked potentials in lumbar spinal stenosis
Leinonen V, Määttä S, Taimela S, Herno A, Kankaanpää M, Partanen J, Kansanen M, Hänninen O, Airaksinen O. 2002. Spine. 27: 975-983 -
Disc herniation-related back pain impairs feed-forward control of paraspinal muscles
Leinonen V, Kankaanpää M, Luukkonen M, Hänninen O, Airaksinen O, Taimela S. 2001. Spine. 26: E367-E372 -
Back and hip extensor activities during trunk flexion/extension: effects of low back pain and rehabilitation
Leinonen V, Kankaanpää M, Airaksinen O, Hänninen O. 2000. Archives of physical medicine and rehabilitation. 81: 32-37