Ville Leinonen

Cerebrospinal Fluid Diagnostics of Alzheimer's Disease in Patients with Idiopathic Normal Pressure Hydrocephalus

Vanninen, Aleksi; Lukkarinen, Heikki; Kokkola, Tarja; Koivisto, Anne M.; Kokki, Merja; Musialowicz, Tadeusz; Hiltunen, Mikko; Zetterberg, Henrik; Leinonen, Ville; Herukka, Sanna Kaisa; Rauramaa, Tuomas. 2023. Journal of Alzheimer's disease. 94: 727-736

Concordance of Alzheimer’s Disease-Related Biomarkers Between Intraventricular and Lumbar Cerebrospinal Fluid in Idiopathic Normal Pressure Hydrocephalus

Lukkarinen, Heikki; Vanninen, Aleksi; Tesseur, Ina; Pemberton, Darrel; Van Der Ark, Peter; Kokkola, Tarja; Herukka, Sanna-Kaisa; Rauramaa, Tuomas; Hiltunen, Mikko; Blennow, Kaj; Zetterberg, Henrik; Leinonen, Ville. 2023. Journal of Alzheimer's disease. 91: 305-319

Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro

Dolan, Michael-John; Therrien, Martine; Jereb, Saša; Kamath, Tushar; Gazestani, Vahid; Atkeson, Trevor; Marsh, Samuel E.; Goeva, Aleksandrina; Lojek, Neal M.; Murphy, Sarah; White, Cassandra M.; Joung, Julia; Liu, Bingxu; Limone, Francesco; Eggan, Kevin; Hacohen, Nir; Bernstein, Bradley E.; Glass, Christopher K.; Leinonen, Ville; Blurton-Jones, Mathew; Zhang, Feng; Epstein, Charles B.; Macosko, Evan Z.; Stevens, Beth. 2023. Nature immunology. 24: 1382-1390

Normaalipaineisen hydrokefaluksen arvoitus

Leinonen, Ville; Hiltunen, Mikko. 2023. Duodecim. 139: 340-342

Novel cerebrospinal fluid biomarkers correlating with shunt responsiveness in patients with idiopathic normal pressure hydrocephalus

Weiner, Sophia; Junkkari, Antti; Sauer, Mathias; Luikku, Antti; Rauramaa, Tuomas; Kokkola, Tarja; Herukka, Sanna-Kaisa; Blennow, Kaj; Zetterberg, Henrik; Leinonen, Ville; Gobom, Johan. 2023. Fluids and barriers of the cns. 20: . 40

Potent dual MAGL/FAAH inhibitor AKU-005 engages endocannabinoids to diminish meningeal nociception implicated in migraine pain

Della Pietra, Adriana; Krivoshein, Georgii; Ivanov, Konstantin; Giniatullina, Raisa; Jyrkkänen, Henna-Kaisa; Leinonen, Ville; Lehtonen, Marko; van den Maagdenberg, Arn MJM; Savinainen, Juha; Giniatullin, Rashid. 2023. Journal of headache and pain. 24: . 38

Protective Alzheimer's disease-associated APP A673T variant predominantly decreases sAPPβ levels in cerebrospinal fluid and 2D/3D cell culture models

Wittrahm, Rebekka; Takalo, Mari; Kuulasmaa, Teemu; Mäkinen, Petra M; Mäkinen, Petri; Končarević, Saša; Fartzdinov, Vadim; Selzer, Stefan; Kokkola, Tarja; Antikainen, Leila; Martiskainen, Henna; Kemppainen, Susanna; Marttinen, Mikael; Jeskanen, Heli; Rostalski, Hannah; Rahunen, Eija; Kivipelto, Miia; Ngandu, Tiia; Natunen, Teemu; Lambert, Jean-Charles; Tanzi, Rudolph E; Kim, Doo Yeon; Rauramaa, Tuomas; Herukka, Sanna-Kaisa; Soininen, Hilkka; Laakso, Markku; Pike, Ian; Leinonen, Ville; Haapasalo, . 2023. Neurobiology of disease. 182:

Protocol of identical exercise programs with and without specific breathing techniques for the treatment of chronic non-specific low back pain: randomized feasibility trial with two-month follow-up

Mikkonen, Jani; Luomajoki, Hannu; Airaksinen, Olavi; Goubert, Liesbet; Leinonen, Ville. 2023. Bmc musculoskeletal disorders. 24: . 354

Reduced binding of apoE4 to complement factor H promotes amyloid‐β oligomerization and neuroinflammation

Chernyaeva, Larisa; Ratti, Giorgio; Teirilä, Laura; Fudo, Satoshi; Rankka, Uni; Pelkonen, Anssi; Korhonen, Paula; Leskinen, Katarzyna; Keskitalo, Salla; Salokas, Kari; Gkolfinopoulou, Christina; Crompton, Katrina E; Javanainen, Matti; Happonen, Lotta; Varjosalo, Markku; Malm, Tarja; Leinonen, Ville; Chroni, Angeliki; Saavalainen, Päivi; Meri, Seppo; Kajander, Tommi; Wollman, Adam JM; Nissilä, Eija; Haapasalo, Karita. 2023. Embo reports. 24:

Serum Cathepsin S Levels Do Not Show Alterations in Different Clinical, Neuropathological, or Genetic Subtypes of Frontotemporal Dementia Patients nor in Comparison to Healthy Control Individuals

Heikkinen, Sami; Huber, Nadine; Katisko, Kasper; Kokkola, Tarja; Hartikainen, Päivi; Krüger, Johanna; Leinonen, Ville; Korhonen, Ville E; Herukka, Sanna-Kaisa; Remes, Anne M; Borroni, Barbara; Alberici, Antonella; Libri, Ilenia; Solje, Eino; Haapasalo, Annakaisa. 2023. Journal of Alzheimer's disease. 93: 395-401

Cerebrospinal fluid biomarkers that reflect clinical symptoms in idiopathic normal pressure hydrocephalus patients

Lukkarinen, Heikki; Jeppsson, Anna; Wikkelsö, Carsten; Blennow, Kaj; Zetterberg, Henrik; Constantinescu, Radu; Remes, Anne M.; Herukka, Sanna-Kaisa; Hiltunen, Mikko; Rauramaa, Tuomas; Nägga, Katarina; Leinonen, Ville; Tullberg, Mats. 2022. Fluids and barriers of the cns. 19: . 11

Computer-based Eye-tracking Analysis of King-Devick Test Differentiates Persons With Idiopathic Normal Pressure Hydrocephalus From Cognitively Unimpaired

Lehtola, Juha-Matti; Kärkkäinen, Virve; Andberg, Sami; Hannonen, Sanna; Rusanen, Minna; Saari, Toni; Korhonen, Ville; Hokkanen, Laura; Hallikainen, Merja; Hänninen, Tuomo; Kaarniranta, Kai; Bednarik, Roman; Leinonen, Ville; Koivisto, Anne M. 2022. Alzheimer disease and associated disorders. 36: 340-346

Editorial: Toward a better understanding of the pathophysiology and clinical management of idiopathic normal pressure hydrocephalus

Karagiozov, Kostadin L.; Leinonen, Ville; Miyajima, Masakazu; Nakajima, Madoka. 2022. Frontiers in neurology. 13: . 1013720

Genome-wide meta-analysis for Alzheimer’s disease cerebrospinal fluid biomarkers

Jansen, Iris E.; van der Lee, Sven J.; Gomez-Fonseca, Duber; de Rojas, Itziar; Dalmasso, Maria Carolina; Grenier-Boley, Benjamin; Zettergren, Anna; Mishra, Aniket; Ali, Muhammad; Andrade, Victor; Bellenguez, Céline; Kleineidam, Luca; Küçükali, Fahri; Sung, Yun Ju; Tesí, Niccolo; Vromen, Ellen M.; Wightman, Douglas P.; Alcolea, Daniel; Alegret, Montserrat; Alvarez, Ignacio; Amouyel, Philippe; Athanasiu, Lavinia; Bahrami, Shahram; Bailly, Henri; Belbin, Olivia; Bergh, Sverre; Bertram, Lars; Biesse. 2022. Acta neuropathologica. 144: 821-842

In vivo assessment of Lewy body and beta-amyloid copathologies in idiopathic normal pressure hydrocephalus: prevalence and associations with clinical features and surgery outcome

Giannini, Giulia; Baiardi, Simone; Dellavalle, Sofia; Zenesini, Corrado; Cevoli, Sabina; Danner, Nils; Jyrkkänen, Henna-Kaisa; Rossi, Marcello; Polischi, Barbara; Quadalti, Corinne; Stefanini, Camilla; Cortelli, Pietro; Milletti, David; Herukka, Sanna-Kaisa; Palandri, Giorgio; Leinonen, Ville; Parchi, Piero. 2022. Fluids and barriers of the cns. 19: . 71

Incidence and risk factors of spinal cord stimulation for persistent or recurrent pain after lumbar spine surgery: a population-based study

Huttunen, Jukka; Fraunberg, Mikael von und zu; Ikäheimo, Tiina-Mari; Jyrkkänen, Henna-Kaisa; Nissen, Mette; Leinonen, Ville; Salmenkivi, Jyrki; Malmivaara, Antti; Sirola, Joonas; Sund, Reijo. 2022. Acta neurochirurgica. 164: 2645-2653

Kaularangan luisen juuriaukkoahtauman kirurginen hoito

Kotkansalo, Anna; Leinonen, Ville; Korhonen, Katariina; Rinne, Jaakko; Malmivaara, Antti . 2022. Duodecim. 138: 769-777

Neuropathological findings in possible normal pressure hydrocephalus: A post-mortem study of 29 cases with lifelines

Hänninen, JJ; Nakajima, M; Vanninen, A; Hytönen, S; Rummukainen, J; Koivisto, AM; Jääskeläinen, JE; Soininen, H; Sutela, A; Vanninen, R; Hiltunen, M; Leinonen, V; Rauramaa, T. 2022. Free neuropathology. 3: 1-17

Postural sway does not differentiate individuals with chronic low back pain, single and multisite chronic musculoskeletal pain, or pain-free controls: a cross-sectional study of 229 subjects

Mikkonen, Jani; Leinonen, Ville; Kaski, Diego; Hartvigsen, Jan; Luomajoki, Hannu; Selander, Tuomas; Airaksinen, Olavi. 2022. Spine journal. 22: 1523-1534

Serum total TDP-43 levels are decreased in frontotemporal dementia patients with C9orf72 repeat expansion or concomitant motoneuron disease phenotype

Katisko, Kasper; Huber, Nadine; Kokkola, Tarja; Hartikainen, Päivi; Krüger, Johanna; Heikkinen, Anna-Leena; Paananen, Veera; Leinonen, Ville; Korhonen, Ville E.; Helisalmi, Seppo; Herukka, Sanna-Kaisa; Cantoni, Valentina; Gadola, Yasmine; Archetti, Silvana; Remes, Anne M.; Haapasalo, Annakaisa; Borroni, Barbara; Solje, Eino. 2022. Alzheimer's research and therapy. 14: . 151

Shortening of Saccades as a Possible Easy-to-Use Biomarker to Detect Risk of Alzheimer’s Disease

Hannonen, Sanna; Andberg, Sami; Kärkkäinen, Virve; Rusanen, Minna; Lehtola, Juha-Matti; Saari, Toni; Korhonen, Ville; Hokkanen, Laura; Hallikainen, Merja; Hänninen, Tuomo; Leinonen, Ville; Kaarniranta, Kai; Bednarik, Roman; Koivisto, Anne M.. 2022. Journal of Alzheimer's disease. 88: 609-618

The effect of antithrombotic therapy on the recurrence and outcome of chronic subdural hematoma after burr-hole craniostomy in a population-based cohort

Kerttula, Santtu; Huttunen, Jukka; Leinonen, Ville; Kämäräinen, Olli Pekka; Danner, Nils. 2022. Acta neurochirurgica. 164: 2699-2708

The effect of shunt surgery on corticospinal excitability in idiopathic normal pressure hydrocephalus: a transcranial magnetic stimulation study

Sirkka, Jani; Säisänen, Laura; Julkunen, Petro; Könönen, Mervi; Kallioniemi, Elisa; Leinonen, Ville; Danner, Nils. 2022. Fluids and barriers of the cns. 19: . 89

5-Year health-related quality of life outcome in patients with idiopathic normal pressure hydrocephalus

Junkkari, A; Sintonen, H; Danner, N; Jyrkkänen, HK; Rauramaa, T; Luikku, AJ; Koivisto, AM; Roine, RP; Viinamäki, H; Soininen, H; Jääskeläinen, JE; Leinonen, V. 2021. Journal of neurology. 268: 3283-3293

A Novel Genetic Marker for the C9orf72 Repeat Expansion in the Finnish Population

Rostalski, H; Korhonen, V; Kuulasmaa, T; Solje, E; Krüger, J; Gen, F; Kaivola, K; Eide, PK; Lambert, JC; Julkunen, V; Tienari, PJ; Remes, AM; Leinonen, V; Hiltunen, M; Haapasalo, A. 2021. Journal of Alzheimer's disease. 83: 1325-1332

Alzheimerin taudin uudet riskigeenit - keskiössä mikrogliasolut

Martiskainen, Henna; Takalo, Mari; Konttinen, Henna; Malm, Tarja; Haapasalo, Annakaisa; Leinonen, Ville; Hiltunen, Mikko. 2021. Duodecim. 137: 1375- 1382

Cerebrospinal fluid dynamics in idiopathic intracranial hypertension: a literature review and validation of contemporary findings

Kaipainen, Aku L; Martoma, Erik; Puustinen, Tero; Tervonen, Joona; Jyrkkänen, Henna-Kaisa; Paterno, Jussi J; Kotkansalo, Anna; Rantala, Susanna; Vanhanen, Ulla; Leinonen, Ville; Lehto, Soili M; Iso-Mustajärvi, Matti; Elomaa, Antti-Pekka; Qvarlander, Sara; Huuskonen, Terhi J. 2021. Acta neurochirurgica. 163: 3353-3368

Cross-Cultural Adaptation, Reliability, and Psychophysical Validation of the Pain and Sleep Questionnaire Three-Item Index in Finnish

Mikkonen, Jani; Leinonen, Ville; Luomajoki, Hannu; Kaski, Diego; Kupari, Saana; Tarvainen, Mika; Selander, Tuomas; Airaksinen, Olavi. 2021. Journal of clinical medicine. 10: 4887

Cross-cultural adaptation and validation of the Finnish version of the central sensitization inventory and its relationship with dizziness and postural control

Mikkonen, Jani; Luomajoki, Hannu; Airaksinen, Olavi; Neblett, Randy; Selander, Tuomas; Leinonen, Ville. 2021. Bmc neurology. 21: 141

Elevated CSF LRG and Decreased Alzheimer's Disease Biomarkers in Idiopathic Normal Pressure Hydrocephalus

Vanninen, Aleksi; Nakajima, Madoka; Miyajima, Masakazu; Rauramaa, Tuomas; Kokki, Merja; Musialowicz, Tadeusz; Mäkinen, Petra M; Herukka, Sanna-Kaisa; Koivisto, Anne M; Jääskeläinen, Juha E; Hiltunen, Mikko; Leinonen, Ville. 2021. Journal of clinical medicine. 10: 1105

Ex Vivo Porcine Models Are Valid for Testing and Training Microsurgical Lumbar Decompression Techniques

Säteri, Tuomas; Nurro, Jussi; Hätinen, Olli-Pekka; Hakulinen, Mikko; Leinonen, Ville; Elomaa, Antti-Pekka. 2021. World neurosurgery. 155: e64-e74

FTLD Patient-Derived Fibroblasts Show Defective Mitochondrial Function and Accumulation of p62

Leskelä, S; Hoffmann, D; Rostalski, H; Huber, N; Wittrahm, R; Hartikainen, P; Korhonen, V; Leinonen, V; Hiltunen, M; Solje, E; Remes, AM; Haapasalo, A. 2021. Molecular neurobiology. 58: 5438-5458

Functional Characterization of Human Pluripotent Stem Cell-Derived Models of the Brain with Microelectrode Arrays

Pelkonen, Anssi; Pistono, Cristiana; Klecki, Pamela; Gómez-Budia, Mireia; Dougalis, Antonios; Konttinen, Henna; Stanová, Iveta; Fagerlund, Ilkka; Leinonen, Ville; Korhonen, Paula; Malm, Tarja. 2021. Cells. 2022; 11: 106

Gabapentinoids Associated With Lower Explantation Rate in 203 Patients With Spinal Cord Stimulation for Failed Back Surgery Syndrome

Nissen, Mette; Ikäheimo, Tiina-Mari; Huttunen, Jukka; Leinonen, Ville; Jyrkkänen, Henna-Kaisa; von und zu Fraunberg, Mikael. 2021. Neurosurgery. 89: 626-634

MECP2 Increases the Pro-Inflammatory Response of Microglial Cells and Phosphorylation at Serine 423 Regulates Neuronal Gene Expression upon Neuroinflammation

Wittrahm, Rebekka; Takalo, Mari; Marttinen, Mikael; Kuulasmaa, Teemu; Mäkinen, Petra; Kemppainen, Susanna; Martiskainen, Henna; Rauramaa, Tuomas; Pike, Ian; Leinonen, Ville; Natunen, Teemu; Haapasalo, Annakaisa; Hiltunen, Mikko. 2021. Cells. 10: 860

Plasma miR-9-3p and miR-136-3p as Potential Novel Diagnostic Biomarkers for Experimental and Human Mild Traumatic Brain Injury

Das Gupta, Shalini; Ciszek, Robert; Heiskanen, Mette; Lapinlampi, Niina; Kukkonen, Janne; Leinonen, Ville; Puhakka, Noora; Pitkänen, Asla. 2021. International journal of molecular sciences. 22: 1563

Preoperative measurements on MRI in Chiari 1 patients fail to predict outcome after decompressive surgery

Jussila, Miro-Pekka; Nissilä, Juho; Vakkuri, Minna; Olsén, Päivi; Niinimäki, Jaakko; Leinonen, Ville; Serlo, Willy; Salokorpi, Niina; Suo-Palosaari, Maria. 2021. Acta neurochirurgica. [Epub ahead of print 11 May 2021]: 1-10

S327 phosphorylation of the presynaptic protein SEPTIN5 increases in the early stages of neurofibrillary pathology and alters the functionality of SEPTIN5

Ferreira, Catarina B.; Marttinen, Mikael; Coelho, Joana E.; Paldanius, Kaisa M.A.; Takalo, Mari; Mäkinen, Petra; Leppänen, Luukas; Miranda-Lourenço, Catarina; Fonseca-Gomes, João; Tanqueiro, Sara R.; Vaz, Sandra H.; Belo, Rita F.; Sebastião, Ana Maria; Leinonen, Ville; Soininen, Hilkka; Pike, Ian; Haapasalo, Annakaisa; Lopes, Luísa V.; de Mendonça, Alexandre; Diógenes, Maria José; Hiltunen, Mikko. 2021. Neurobiology of disease. 2022; 163: 105603

Shunt performance in 349 patients with hydrocephalus after aneurysmal subarachnoid hemorrhage

Tervonen, Joona; Adams, Hadie; Lindgren, Antti; Elomaa, Antti-Pekka; Kämäräinen, Olli-Pekka; Kärkkäinen, Virve; von und zu Fraunberg, Mikael; Huttunen, Jukka; Koivisto, Timo; Jääskeläinen, Juha E.; Leinonen, Ville; Huuskonen, Terhi J.. 2021. Acta neurochirurgica. 163: 2703-2714

Surgically treated C1 fractures: a population-based study

Ylönen, Henri; Danner, Nils; Jyrkkänen, Henna-Kaisa; Kämäräinen, Olli-Pekka; Leinonen, Ville; Huttunen, Jukka. 2021. World neurosurgery. 154: e333-e342

The CERAD Neuropsychological Battery in Patients with Idiopathic Normal Pressure Hydrocephalus Compared with Normal Population and Patients with Mild Alzheimer's Disease

Nerg, Ossi; Junkkari, Antti; Hallikainen, Ilona; Rauramaa, Tuomas; Luikku, Antti; Hiltunen, Mikko; Jääskeläinen, Juha E.; Leinonen, Ville; Hänninen, Tuomo; Koivisto, Anne;. 2021. Journal of Alzheimer's disease. 81: 1117-1130

Time Trends of Cerebrospinal Fluid Biomarkers of Neurodegeneration in Idiopathic Normal Pressure Hydrocephalus

Lukkarinen, Heikki; Tesseur, Ina; Pemberton, Darrel; Van Der Ark, Peter; Timmers, Maarten; Slemmon, Randy; Janssens, Luc; Streffer, Johannes; Van Nueten, Luc; Bottelbergs, Astrid; Rauramaa, Tuomas; Koivisto, Anne M.; Herukka, Sanna-Kaisa; Korhonen, Ville E.; Junkkari, Antti; Hiltunen, Mikko; Engelborghs, Sebastiaan; Blennowk, Kaj; Zetterbergk, Henrik; Kolb, Hartmuth C.; Leinonen, Ville. 2021. Journal of Alzheimer's disease. 80: 1629-1642

Upper limb dysfunction and activities in daily living in idiopathic normal pressure hydrocephalus

Sirkka, Jani; Parviainen, Marita; Jyrkkänen, Henna-Kaisa; Koivisto, Anne M.; Säisänen, Laura; Rauramaa, Tuomas; Leinonen, Ville; Danner, Nils. 2021. Acta neurochirurgica. 163: 2675-2683

iNPH - the mystery resolving

Leinonen, Ville; Kuulasmaa, Teemu; Hiltunen, Mikko. 2021. Embo molecular medicine. 13: e13720

Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-ß from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy

Carare, RO; Aldea, R; Agarwal, N; Bacskai, BJ; Bechman, I; Boche, D; Bu, G; Bulters, D; Clemens, A; Counts, SE; de Leon, M; Eide, PK; Fossati, S; Greenberg, SM; Hamel, E; Hawkes, CA; Koronyo-Hamaoui, M; Hainsworth, AH; Holtzman, D; Ihara, M; et al [incl. Kanninen, K; Leinonen, V; Malm, T]. 2020. Alzheimer's & dementia : diagnosis, assessment & disease monitoring. 21: e12053

Corticospinal Excitability in Idiopathic Normal Pressure Hydrocephalus: A Transcranial Magnetic Stimulation Study

Sirkka, J; Säisänen, L; Julkunen, P; Könönen, M; Kallioniemi, E; Leinonen, V; Danner, N. 2020. Fluids and barriers of the cns. 17: 6

Diabetes is associated with familial idiopathic normal pressure hydrocephalus: a case-control comparison with family members

Räsänen, Joel; Huovinen, Joel; Korhonen, Ville E; Junkkari, Antti; Kastinen, Sami; Komulainen, Simo; Oinas, Minna; Avellan, Cecilia; Frantzen, Janek; Rinne, Jaakko; Ronkainen, Antti; Kauppinen, Mikko; Lönnrot, Kimmo; Perola, Markus; Koivisto, Anne M; Remes, Anne M; Soininen, Hilkka; Hiltunen, Mikko; Helisalmi, Seppo; Kurki, Mitja I [et al. incl. Jääskeläinen, Juha E: Leinonen, Ville]. 2020. Fluids and barriers of the cns. 17: 57

Diabetic phenotype in mouse and humans reduces the number of microglia around ß-amyloid plaques

Natunen, Teemu; Martiskainen, Henna; Marttinen, Mikael; Gabbouj, Sami; Koivisto, Hennariikka; Kemppainen, Susanna; Kaipainen, Satu; Takalo, Mari; Svobodová, Helena; Leppänen, Luukas; Kemiläinen, Benjam; Ryhänen, Simo; Kuulasmaa, Teemu: Rahunen, Eija: Juutinen, Sisko; Mäkinen, Petra; Miettinen, Pasi; Rauramaa, Tuomas; Pihlajamäki, Jussi; Haapasalo, Annakaisa; et al [incl. Leinonen, Ville; Tanila, Heikki; Hiltunen, Mikko]. 2020. Molecular neurodegeneration. 15: 66

Finnish Study of Intraoperative Irrigation Versus Drain Alone After Evacuation of Chronic Subdural Haematoma (FINISH): A Study Protocol for a Multicentre Randomised Controlled Trial

Tommiska, P; Raj, R; Schwartz, C; Kivisaari, R; Luostarinen, T; Satopää, J; Taimela, S; Järvinen, T; Ranstam, J; Frantzen, J; Posti, J; Luoto, TM; Leinonen, V; Tetri, S; Koivisto, T; Lönnrot, K. 2020. BMJ open. 10: e038275

Higher Preimplantation Opioid Doses Associated With Long-Term Spinal Cord Stimulation Failure in 211 Patients With Failed Back Surgery Syndrome

Nissen, Mette; Ikäheimo, Tiina-Mari; Huttunen, Jukka; Leinonen, Ville; Jyrkkänen, Henna-Kaisa; von Und Zu Fraunberg, Mikael. 2020. Neuromodulation. 2021; 24: 102-111

LifeTime and improving European healthcare through cell-based interceptive medicine

Rajewsky, Nikolaus; Almouzni, Geneviève; Gorski, Stanislaw A; Aerts, Stein; Amit, Ido; Bertero, Michela G; Bock, Christoph; Bredenoord, Annelien L; Cavalli, Giacomo; Chiocca, Susanna; Clevers, Hans; Strooper, Bart De; Eggert, Angelika; Ellenberg, Jan; Fernández, Xosé M; Figlerowicz, Marek; Gasser, Susan M; Hubner, Norbert; Kjems, Jørgen; Knoblich, Jürgen A et al. [incl. Pitkänen, Asla; Leinonen, Ville]. 2020. Nature. 587: 377-386

Occurrence, Risk Factors, and Time Trends for Late Reoperations due to Degenerative Cervical Spine Disease: A Finnish National Register Study of 19 377 Patients Operated on Between 1999 and 2015

Kotkansalo, Anna; Leinonen, Ville; Korajoki, Merja; Korhonen, Katariina; Rinne, Jaakko; Malmivaara, Antti. 2020. Neurosurgery. 2021; 88: 558-573

PTPR type Q in cerebrospinal fluid reflects ependymal cells dysfunction and is a potential biomarker for adult chronic hydrocephalus

Nakajima, Madoka; Rauramaa, Tuomas; Mäkinen, Petra M; Hiltunen, Mikko; Herukka, Sanna-Kaisa; Kokki, Merja; Musialowicz, Tadeusz; Jyrkkänen, Henna-Kaisa; Danner, Nils; Junkkari, Antti; Koivisto, Anne M; Jääskeläinen, Juha E; Miyajima, Masakazu; Ogino, Ikuko; Furuta, Akiko; Akiba, Chihiro; Kawamura, Kaito; Kamohara, Chihiro; Sugano, Hidenori; Tange, Yuichi; et al. [incl. Leinonen, Ville]. 2020. European journal of neurology. 2021; 28: 389-400

Preoperative Predictors of Better Long-Term Functional Ability and Decreased Pain Following LSS Surgery: A Prospective Observational Study with a 10-year Follow-Up Period

Tuomainen, I; Pesonen, J; Rade, M; Pakarinen, M; Leinonen, V; Kröger, H; Airaksinen, O; Aalto, T. 2020. Spine. 45: 776-783

Presynaptic Vesicle Protein SEPTIN5 Regulates the Degradation of APP C-Terminal Fragments and the Levels of Aß

Marttinen, Mikael; Ferreira, Catarina B; Paldanius, Kaisa M A; Takalo, Mari; Natunen, Teemu; Mäkinen, Petra; Leppänen, Luukas; Leinonen, Ville; Tanigaki, Kenji; Kang, Gina; Hiroi, Noboru; Soininen, Hilkka; Rilla, Kirsi; Haapasalo, Annakaisa; Hiltunen, Mikko. 2020. Cells. 9: 2482

Unfolding the outcomes of surgical treatment of lumbar spinal stenosis-a prospective 5- and 10-year follow-up study

Tuomainen, I; Aalto, T; Pesonen, J; Rade, M; Pakarinen, M; Leinonen, V; Kröger, H; Airaksinen, O. 2020. European spine journal. 29: 2231-2242

Aivovammat

Luoto, Teemu; Leinonen, Ville; Bendel, Stepani; Koivisto, Timo; Jääskeläinen, Juha E. Teoksessa: Leppäniemi, Ari; Kuokkanen, Hannu; Salminen, Pauliina(toim.) , 2019. Kirurgia. s. 892-905. Kustannus Oy Duodecim

CSF biomarkers distinguish idiopathic normal pressure hydrocephalus from its mimics

Jeppsson, Anna; Wikkelsö, Carsten; Blennow, Kaj; Zetterberg, Henrik; Constantinescu, Radu; Remes, Anne M; Herukka, Sanna-Kaisa; Rauramaa, Tuomas; Nagga, Katarina; Leinonen, Ville; Tullberg, Mats. 2019. Journal of neurology neurosurgery and psychiatry. 90: 1117-1123

Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology: A Systematic Review and Meta-analysis

Bridel, C; van Wieringen, WN; Zetterberg, H; Tijms, BM; Teunissen, CE; Alvarez-Cermeño, JC; Andreasson, U; Axelsson, M; Bäckström, DC; Bartos, A; Bjerke, M; Blennow, K; Boxer, A; Brundin, L; Burman, J; Christensen, T; Fialová, L; Forsgren, L; Frederiksen, JL; Gisslén, M; et al.; and the NFL Group (incl. Leinonen, V). 2019. JAMA neurology. 76: 1035-1048

Finnish Trial on Practices of Anterior Cervical Decompression and Fusion (FACADE): a protocol for a prospective randomised non-inferiority trial comparing outpatient versus inpatient care

Lönnrot, Kimmo; Taimela, Simo; Toivonen, Pirjo; Aronen, Pasi; Koski-Palken, Anniina; Frantzen, Janek; Leinonen, Ville; Silvasti-Lundell, Marja; Förster, Johannes; Jarvinen, Teppo. 2019. BMJ open. 9: 1-8

MIM-Deficient Mice Exhibit Anatomical Changes in Dendritic Spines, Cortex Volume and Brain Ventricles, and Functional Changes in Motor Coordination and Learning

Minkeviciene R, Hlushchenko, I; Virenque, A; Lahti, L; Khanal, P; Rauramaa, T; Koistinen, A; Leinonen, V; Noe, FM; Hotulainen, P. 2019. Frontiers in molecular neuroscience. 12: 276

Normaalipaineisen hydrokefaluksen kliininen kuva, diagnostiset tutkimukset ja hoito

Leinonen, Ville; Junkkari, Antti; Rauramaa, Tuomas; Jääskeläinen, Juha E; Vanninen, Ritva; Savolainen, Sakari; Hiltunen, Mikko; Remes, Anne M; Koivisto, Anne M. 2019. Duodecim. 135: 265-273

Predicting Development of Alzheimer's Disease in Patients with Shunted Idiopathic Normal Pressure Hydrocephalus

Luikku, AJ; Hall, A; Nerg, O; Koivisto, AM; Hiltunen, M; Helisalmi, S; Herukka, SK; Junkkari, A; Sutela, A; Kojoukhova, M; Korhonen, V; Mattila, J; Lötjönen, J; Rummukainen, J; Alafuzoff, I; Jääskeläinen, JE; Remes, AM; Solomon, A; Kivipelto, M; Soininen, H; et al. [Incl. Rauramaa, T; Leinonen, V]. 2019. Journal of Alzheimer's disease. 71: 1233-1243

Prevalence of C9ORF72 Expansion in a Large Series of Patients with Idiopathic Normal-Pressure Hydrocephalus

Korhonen, VE; Remes, AM; Helisalmi, S; Rauramaa, T; Sutela, A; Vanninen, R; Suhonen, NM; Haapasalo, A; Hiltunen, M; Jääskeläinen, JE; Soininen, H; Koivisto, AM; Leinonen, V. 2019. Dementia and geriatric cognitive disorders. 47: 91-103

Psychiatric disorders are a common prognostic marker for worse outcome in patients with idiopathic intracranial hypertension

Puustinen, Tero; Tervonen, Joona; Avellan, Cecilia; Jyrkkänen, Henna-Kaisa; Paterno, Jussi J; Hartikainen, Päivi; Vanhanen, Ulla; Leinonen, Ville; Lehto, Soili M; Elomaa, Antti-Pekka; Huttunen, Terhi J. 2019. Clinical neurology and neurosurgery. 186: 105527

Surgery for degenerative cervical spine disease in Finland, 1999-2015

Kotkansalo, A; Leinonen, V; Korajoki, M; Salmenkivi, J; Korhonen, K; Malmivaara, A. 2019. Acta neurochirurgica. 161: 2147-2159

Surgical techniques for degenerative cervical spine in Finland from 1999 to 2015

Kotkansalo, A; Malmivaara, A; Korajoki, M; Korhonen, K; Leinonen, V. 2019. Acta neurochirurgica. 161: 2161-2173

The Kuopio idiopathic normal pressure hydrocephalus protocol: initial outcome of 175 patients

Junkkari, A; Luikku, A J; Danner, N; Jyrkkänen, H K; Rauramaa, T; Korhonen, V E; Koivisto, A M; Nerg, O; Kojoukhova, M; Huttunen, T J; Jääskeläinen, J E; Leinonen, V. 2019. Fluids and barriers of the cns. 16: 21

[11C]PIB PET Is Associated with the Brain Biopsy Amyloid-ß Load in Subjects Examined for Normal Pressure Hydrocephalus

Rinne, JO; Suotunen, T; Rummukainen, J; Herukka, SK; Nerg, O; Koivisto, AM; Rauramaa, T; Någren, K; Hiltunen, M; Alafuzoff, I; Rinne, J; Jääskeläinen, JE; Soininen, H; Leinonen, V. 2019. Journal of Alzheimer's disease. 67: 1343-1351

Aikuisten hydrokefalus ja sunttikomplikaatiot

Jääskeläinen, Juha E; Leinonen, Ville. Teoksessa: Jousimaa, Jukkapekka; Alenius, Heidi; Atula, Sari; Berghem, Nora; Kattainen, Anna; Kunnamo, Ilkka; Pelttari, Hanna; Teikar, Martti(toim.) , 2018. Lääkärin käsikirja [online]. s. -. Kustannus Oy Duodecim

Alterations in mitochondria-endoplasmic reticulum connectivity in human brain biopsies from idiopathic normal pressure hydrocephalus patients

Leal, NS; Dentoni, G; Schreiner, B; Kämäräinen, OP; Partanen, N; Herukka, SK; Koivisto, AM; Hiltunen, M; Rauramaa, T; Leinonen, V; Ankarcrona, M. 2018. Acta neuropathologica communications. 6: 102

Copy number loss in SFMBT1 is common among Finnish and Norwegian patients with iNPH

Korhonen, VE; Helisalmi, S; Jokinen, A; Jokinen, I; Lehtola, JM; Oinas, M; Lönnrot, K; Avellan, C; Kotkansalo, A; Frantzen, J; Rinne, J; Ronkainen, A; Kauppinen, M; Junkkari, A; Hiltunen, M; Soininen, H; Kurki, M; Jääskeläinen, JE; Koivisto, AM; Sato, H; et al. 2018. Neurology : Genetics. 4: e291

Ensihoidosta neurotehohoitoon

Leinonen, Ville; Kurola, Jouni; Lång, Maarit; Niemelä, Mika; Jääskeläinen, Juha E. Teoksessa: Leppäniemi, Ari; Kuokkanen, Hannu; Salminen, Pauliina(toim.) , 2018. Kirurgia. s. 882-885. Duodecim

Incidence, comorbidities, and mortality in idiopathic normal pressure hydrocephalus

Pyykkö, OT; Nerg, O; Niskasaari, HM; Niskasaari, T; Koivisto, AM; Hiltunen, M; Pihlajamäki, J; Rauramaa, T; Kojoukhova, M; Alafuzoff, I; Soininen, H; Jääskeläinen, JE; Leinonen, V. 2018. World neurosurgery. 112: e624-e631

Interrelationship between the Levels of C9orf72 and Amyloid-ß Protein Precursor and Amyloid-ß in Human Cells and Brain Samples

Leskelä, S; Takalo, M; Marttinen, M; Huber, N; Paananen, J; Mitra, V; Rauramaa, T; Mäkinen, P; Leinonen, V; Soininen, H; Pike, I; Remes, AM; Hiltunen, M; Haapasalo, A. 2018. Journal of Alzheimer's disease. 62: 269-278

Long-Term Outcome of Spinal Cord Stimulation in Failed Back Surgery Syndrome: 20 Years of Experience With 224 Consecutive Patients

Nissen, Mette; Ikäheimo, Tiina-Mari; Huttunen, Jukka; Leinonen, Ville; von Und Zu Fraunberg, Mikael. 2018. Neurosurgery. 2019; 84: 1011-1018

Molecular Mechanisms of Synaptotoxicity and Neuroinflammation in Alzheimer's Disease

Marttinen, Mikael; Takalo, Mari; Natunen, Teemu; Wittrahm, Rebekka; Gabbouj, Sami; Kemppainen, Susanna; Leinonen, Ville; Tanila, Heikki; Haapasalo, Annakaisa; Hiltunen, Mikko. 2018. Frontiers in neurology. 12: 963

Neurokirurgia ja neurotautien yksilöllistetty hoito Suomessa

Niemelä, Mika; Leinonen, Ville; Koivisto, Timo; Kumpulainen, Timo; Öhman, Juha; Rinne, Jaakko; Jääskeläinen, Juha E. Teoksessa: Leppäniemi, Ari; Kuokkanen, Hannu; Salminen, Pauliina(toim.) , 2018. Kirurgia. s. 874-875. Duodecim

Neurokirurgisesti hoidettavien tautien oireet ja kuvantaminen

Leinonen, Ville; Jääskeläinen, Juha E. Teoksessa: Leppäniemi, Ari; Kuokkanen, Hannu; Salminen, Pauliina(toim.) , 2018. Kirurgia. s. 880-882. Duodecim

Prevalence of Schizophrenia in Idiopathic Normal Pressure Hydrocephalus

Vanhala, V; Junkkari, A; Korhonen, VE; Kurki, MI; Hiltunen, M; Rauramaa, T;, Nerg, O;, Koivisto, AM; Remes, AM; Perälä, J; Suvisaari, J; Lehto, S; Viinamäki, H; Soininen, H; Jääskeläinen, JE; Leinonen, V. 2018. Neurosurgery. 2019; 84: 883-889

Spinaalikanavan sairaudet

Leinonen, Ville; Jääskeläinen, Juha E. Teoksessa: Leppäniemi, Ari; Kuokkanen, Hannu; Salminen, Pauliina(toim.) , 2018. Kirurgia. s. 938-951. Duodecim

Sushi repeat-containing protein X-Linked 2 - a novel phylogenetically conserved hypothalamo-pituitary protein

Anwer, M; Bolkvadze, T; Ndode-Ekane, XE; Puhakka, N; Rauramaa, T; Leinonen, V; van Vliet, EA; Swaab, DF; Haapasalo, A; Leskelä, S; Bister, N; Malm, T; Carlson, S; Aronica, E; Pitkänen, A. 2018. Journal of comparative neurology. 526: 1806-1819

Value stream map assessment of the extended day: 23h surgery model

Ruohoaho, Ulla-Maija; Kokki, Merja; Hirvonen, Jouni; Joukainen, Sarianna; Aaltomaa, Sirpa; von und zu Fraunberg, Mikael; Leinonen, Ville; Reijula, Jori. 2018. Intelligent buildings international. [Epub 21 MAR 2018]: -

Alzheimer's Disease-Related Polymorphisms in Shunt-Responsive Idiopathic Normal Pressure Hydrocephalus

Huovinen J, Helisalmi S, Paananen J, Laiterä T, Kojoukhova M, Sutela A, Vanninen R, Laitinen M, Rauramaa T, Koivisto AM, Remes AM, Soininen H, Kurki M, Haapasalo A, Jääskeläinen JE, Hiltunen M, Leinonen V. 2017. Journal of Alzheimer's disease. 60: 1077-1085

Cerebrospinal fluid circulation and hydrocephalus

Leinonen V, Vanninen R, Rauramaa T. Teoksessa: Kovacs Gabor G, Alafuzoff Irina(toim.) , 2017. Handbook of Clinical Neurology. Neuropathology. s. 39-50. Elsevier

Frontotemporal dementia as a comorbidity to idiopathic normal pressure hydrocephalus (iNPH): a short review of literature and an unusual case

Korhonen VE, Solje E, Suhonen NM, Rauramaa T, Vanninen R, Remes AM, Leinonen V. 2017. Fluids and barriers of the cns. 14: 10

Immunohistochemical Characterization and Sensitivity to Human Adenovirus Serotypes 3, 5, and 11p of New Cell Lines Derived from Human Diffuse Grade II to IV Gliomas

Niittykoski Minna, von und zu Fraunberg Mikael, Martikainen Miika, Rauramaa, Immonen Arto, Koponen Susanna, Leinonen Ville, Vähä-Koskela Markus, Zhang Qiwei, Kühnel Florian, Mei Ya-Fang, Ylä-Herttuala Seppo, Jääskeläinen Juha E, Hinkkanen Ari. 2017. Translational oncology. 10: 772-779

Niskakipu (aikuiset) : Käypä hoito -suositus (Päivitystiivistelmä)

Karppinen Jaro, Laimi Katri, Leinonen Ville, Malmivaara Antti, Niinimäki Jaakko, Airaksinen Olavi, Arokoski Jari, Auvinen Juha, Jääskeläinen Juhani, Martimo Kari-Pekka, Salo Petri, Soinne Lauri. 2017. Duodecim. 133: 699-700

Raised intracranial pressure and brain edema

Leinonen V, Vanninen R, Rauramaa T. Teoksessa: Kovacs Gabor G, Alafuzoff Irina(toim.) , 2017. Handbook of Clinical Neurology. Neuropathology. s. 25-37. Elsevier

Rate and Risk Factors for Shunt Revision in Pediatric Patients with Hydrocephalus- A Population-Based Study

Tervonen Joona, Leinonen Ville, Jääskeläinen Juha E, Koponen Susanna, Huttunen Terhi J. 2017. World neurosurgery. 101: 615-622

Why does the health-related quality of life in idiopathic normal pressure hydrocephalus fail to improve despite the favorable clinical outcome?

Junkkari Antti, Roine Risto P, Luikku Antti, Rauramaa Tuomas, Sintonen Harri, Nerg Ossi, Koivisto Anne M, Häyrinen Antti, Viinamäki Heimo, Soininen Hilkka, Jääskeläinen Juha E, Leinonen Ville. 2017. World neurosurgery. 108: 356-366

Aneurysmal Subarachnoid Hemorrhage Patients' Risk Assessment for Shunting (aSAH-PARAS): An International Collaborative Study and Initiation of a Consortium

Adams H, Ban VS, Leinonen V, Aoun SG, Huttunen J, Saavalainen T, Lindgren A, Frosen J, Fraunberg M, Koivisto TS, Hernesniemi JA, Welch BG, Jääskeläinen J. 2016. Neurosurgery

Associations of intracranial pressure with brain biopsy, radiological findings, and shunt surgery outcome in patients with suspected idiopathic normal pressure hydrocephalus

Kojoukhova Maria, Vanha Krista-Irina, Timonen Matti, Koivisto Anne M, Nerg Ossi, Rummukainen Jaana, Rauramaa Tuomas, Vanninen Ritva, Jääskeläinen Juha E, Sutela Anna, Leinonen Ville. 2016. Acta neurochirurgica. 2017; 159: 51-61

Effects of Alzheimer's Disease-Associated Risk Loci on Amyloid-ß Accumulation in the Brain of Idiopathic Normal Pressure Hydrocephalus Patients

Laiterä Tiina, Paananen Jussi, Helisalmi Seppo, Sarajärvi Timo, Huovinen Joel, Laitinen Marjo, Rauramaa Tuomas, Alafuzoff Irina, Remes Anne M, Soininen Hilkka, Haapasalo Annakaisa, Jääskeläinen Juha E, Leinonen Ville, Hiltunen Mikko. 2016. Journal of Alzheimer's disease. 2017; 55: 995-1003

Familial idiopathic normal pressure hydrocephalus

Huovinen J, Kastinen S, Komulainen S, Oinas M, Avellan C, Frantzen J, Rinne J, Ronkainen A, Kauppinen M, Lönnrot K, Perola M, Pyykkö OT, Koivisto AM, Remes AM, Soininen H, Hiltunen M, Helisalmi S, Kurki M, Jääskeläinen JE, Leinonen V. 2016. Journal of the neurological sciences. 368: 11-18

Health-related quality-of-life outcome in patients with idiopathic normal-pressure hydrocephalus - a 1-year follow-up study

Junkkari A, Häyrinen A, Rauramaa T, Sintonen H, Nerg O, Koivisto AM, Roine RP, Viinamäki H, Soininen H, Luikku A, Jääskeläinen JE, Leinonen V. 2016. European journal of neurology. 24: 58-66

High Risk of Dementia in Ventricular Enlargement with Normal Pressure Hydrocephalus Related Symptoms1

Koivisto Anne M, Kurki Mitja, Alafuzoff Irina, Sutela Anna, Rummukainen Jaana, Savolainen Sakari, Vanninen Ritva, Jääskeläinen Juha E, Soininen Hilkka, Leinonen Ville. 2016. Journal of Alzheimer's disease. 52: 497-507

Hätäkraniotomiat Pohjois-Karjalan keskussairaalassa vuosina 2006 - 2014

Aro Ellinoora, Jääskeläinen Juha E, Reinikainen Matti, Leinonen Ville, Hakala Tapio. 2016. Duodecim. 132: 858-65

Implantable RF-coil with multiple electrodes for long-term EEG-fMRI monitoring in rodents

Pirttimäki T, Salo RA, Shatillo A, Kettunen MI, Paasonen J, Sierra A, Jokivarsi K, Leinonen V, Andrade P, Quittek S, Pitkänen A, Gröhn O. 2016. Journal of neuroscience methods. 274: 154-163

Multimodal analysis to predict shunt surgery outcome of 284 patients with suspected idiopathic normal pressure hydrocephalus

Luikku Antti J, Hall Anette, Nerg Ossi, Koivisto Anne M, Hiltunen Mikko, Helisalmi Seppo, Herukka Sanna-Kaisa, Sutela Anna, Kojoukhova Maria, Mattila Jussi, Lötjönen Jyrki, Rummukainen Jaana, Alafuzoff Irina, Jääskeläinen Juha E, Remes Anne M, Soininen Hilkka, Leinonen Ville. 2016. Acta neurochirurgica. 158: 2311-2319

Risk of shunting after aneurysmal subarachnoid hemorrhage: a collaborative study and initiation of a consortium

Adams H, Ban VS, Leinonen V, Aoun SG, Huttunen J, Saavalainen T, Lindgren A, Frosen J, Fraunberg M, Koivisto T, Hernesniemi J, Welch BG, Jaaskelainen JE, Huttunen TJ. 2016. Stroke. 47: 2488-96

SEPT8 modulates ß-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1

Kurkinen Kaisa MA, Marttinen Mikael, Turner Laura, Natunen Teemu, Mäkinen Petra, Haapalinna Fanni, Sarajärvi Timo, Gabbouj Sami, Kurki Mitja, Paananen Jussi, Koivisto Anne M, Rauramaa Tuomas, Leinonen Ville, Tanila Hanila, Soininen Hilkka, Lucas Fiona R, Haapasalo Annakaisa, Hiltunen Mikko. 2016. Journal of cell science. 129: 2224-2238

Selling vs. non-selling neuro-oncology research cohorts and manuscripts in the eyes of a grumpy reviewer after 2,000 reviews

Leinonen Ville, Jääskeläinen Juha E. 2016. Acta neurochirurgica. 2017; 159: 3-6

Sub-classification based specific movement control exercises are superior to general exercise in sub-acute low back pain when both are combined with manual therapy: A randomized controlled trial

Lehtola Vesa, Luomajoki Hannu, Leinonen Ville, Gibbons Sean, Airaksinen Olavi. 2016. Bmc musculoskeletal disorders. 17: 135

Amyloid-ß and Tau Dynamics in Human Brain Interstitial Fluid in Patients with Suspected Normal Pressure Hydrocephalus

Herukka Sanna-Kaisa, Rummukainen Jaana, Ihalainen Jouni, von und zu Fraunberg Mikael, Koivisto Anne M, Nerg Ossi, Puli Lakshman K, Seppälä Toni T, Zetterberg Henrik, Pyykkö Okko T, Helisalmi Seppo, Tanila Heikki, Alafuzoff Irina, Hiltunen Mikko, Rinne Jaakko, Soininen Hilkka, Jääskeläinen Juha E, Leinonen Ville. 2015. Journal of Alzheimer's disease. 46: 261-269

Analysis of disruptive events and precarious situations caused by interaction with neurosurgical microscope

Eivazi Shahram, Afkari Hoorieh, Bednarik Roman, Leinonen Ville, Tukiainen Markku, Jääskeläinen Juha E. 2015. Acta neurochirurgica. 157: 1147-1154

Chasing the effects of pre-analytical confounders - a multicenter study on CSF-AD biomarkers

Leitão Maria João, Baldeiras Inês, Herukka Sanna-Kaisa, Pikkarainen Maria, Leinonen Ville, Simonsen Anja Hviid, Perret-Liaudet Armand, Fourier Anthony, Quadrio Isabelle, Veiga Pedro Mota, de Oliveira Catarina Resende. 2015. Frontiers in neurology. 6: 153

Effects of Alzheimer's Disease-Associated Risk Loci on Cerebrospinal Fluid Biomarkers and Disease Progression: A Polygenic Risk Score Approach

Martiskainen Henna, Helisalmi Seppo, Viswanathan Jayashree, Kurki Mitja, Hall Anette, Herukka Sanna-Kaisa, Sarajärvi Timo, Natunen Teemu, Kurkinen Kaisa M.A., Huovinen Jaakko, Mäkinen Petra, Laitinen Marjo, Koivisto Anne M., Mattila Kari M., Lehtimäki Terho, Remes Anne M., Leinonen Ville, Haapasalo Annakaisa, Soininen Hilkka, Hiltunen Mikko. 2015. Journal of Alzheimer's disease. 43: 565-573

Embedding an Eye Tracker into a Surgical Microscope: Requirements, Design, and Implementation

Eivazi Shahram, Bednarik R, Leinonen V, von und zu Fraunberg M, Jääskeläinen JE. 2015. IEEE sensors journal. 2016; 16: 2070-2078

Feasibility of radiological markers in idiopathic normal pressure hydrocephalus

Kojoukhova Maria, Koivisto Anne M, Korhonen Riiika, Remes Anne M, Vanninen Ritva, Soininen Hilkka, Jääskeläinen Juha E, Sutela Anna, Leinonen Ville. 2015. Acta neurochirurgica. 157: 1709-1719

Genetic Variation in delta-Opioid Receptor Associates with Increased ß- and gamma-Secretase Activity in the Late Stages of Alzheimer's Disease

Sarajärvi Timo, Marttinen Mikael, Natunen Teemu, Kauppinen Tarja, Mäkinen Petra, Helisalmi Seppo, Laitinen Marjo, Rauramaa Tuomas, Leinonen Ville, Petäjä-Repo Ulla, Soininen Hilkka, Haapasalo Annakaisa, Hiltunen Mikko. 2015. Journal of Alzheimer's disease. 48: 507-516

Health-related quality of life in patients with idiopathic normal pressure hydrocephalus

Junkkari A, Sintonen H, Nerg O, Koivisto AM, Roine RP, Viinamäki H, Soininen H, Jääskeläinen JE, Leinonen V. 2015. European journal of neurology. published online 24 JUN 2015: 9 p

Normaalipaineinen hydrokefalia

Leinonen Ville, Koivisto Anne. Teoksessa: Timo Erkinjuntti, Anne Remes, Juha Rinne, Hilkka Soininen(toim.) , 2015. Muistisairaudet. s. 187-193. Kustannus Oy Duodecim

Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models

Natunen Teemu, Takalo Mari, Kemppainen Ssusanna, Leskelä Stina, Marttinen Mikael, Kurkinen Kaisa MA, Pursiheimo Juha-Pekka, Sarajärvi Timo, Viswanathan Jayashree, Gabbouj Sami, Solje Eino, Tahvanainen Eveliina, Pirttimäki Tiina, Kurki Mitja, Paananen Jussi, Rauramaa Tuomas, Miettinen Pasi, Mäkinen Petra, Leinonen Ville, Soininen Hilkka et al. 2015. Neurobiology of disease. 2016; 85: 187-205

The Expression of Transthyretin and Amyloid-ß Protein Precursor is Altered in the Brain of Idiopathic Normal Pressure Hydrocephalus Patients

Laiterä Tiina, Kurki Mitja I, Pursiheimo Juha-Pekka, Zetterberg Henrik, Helisalmi Seppo, Rauramaa Tuomas, Alafuzoff Irina, Remes Anne M, Soininen Hilkka, Haapasalo Annakaisa, Jääskeläinen Juha E, Hiltunen Mikko, Leinonen Ville. 2015. Journal of Alzheimer's disease. 48: 959-968

The effect of decompressive surgery on lumbar paraspinal and biceps brachii muscle function and movement perception in lumbar spinal stenosis: a 2-year follow-up

Kääriäinen Tommi, Taimela Simo, Aalto Timo, Kröger Heikki, Herno Arto, Turunen Veli, Savolainen Sakari, Kankaanpää Markku, Airaksinen Olavi, Leinonen Ville. 2015. European spine journal. 2016; 25: 789-794

Alaselkäkipu: Käypä hoito -suositus

Pohjolainen T, Leinonen V, Frantzén J, Haanpää M, Jousimaa JP, Karppinen J, Kuukkanen T, Luoma K, Salmenkivi J, Österman H, Malmivaara A. 2014. Duodecim. hoi20001: artikkeli netissä

Association between bone mineral density and lumbar disc degeneration

Salo Sami, Leinonen Ville, Rikkonen Tomi, Vainio Pauli, Marttila Jarkko, Honkanen Risto, Tuppurainen Marjo, Kröger Heikki, Sirola Joonas. 2014. Maturitas. S0378-5122: 00290-4

Cerebrospinal Fluid Biomarker and Brain Biopsy Findings in Idiopathic Normal Pressure Hydrocephalus

Pyykkö OT, Lumela M, Rummukainen J, Nerg O, Seppälä TT, Herukka SK, Koivisto AM, Alafuzoff I, Puli L, Savolainen S, Soininen H, Jääskeläinen JE, Hiltunen M, Zetterberg H, Leinonen V. 2014. PLoS ONE. 9: 1-10

Correlation of lateral stenosis in MRI with symptoms, walking capacity and EMG findings in patients with surgically confirmed lateral lumbar spinal canal stenosis

Kuittinen Pekka, Sipola Petri, Aalto Timo Juhani, Määttä Sara, Parviainen Anita, Saari Tapani, Sinikallio Sanna, Savolainen Sakari, Turunen Veli, Kröger Heikki, Airaksinen Olavi, Leinonen Ville. 2014. Bmc musculoskeletal disorders. 15: 247

Diagnostic effectiveness of quantitative [18F]flutemetamol PET imaging for detection of fibrillar amyloid ß using cortical biopsy histopathology as the standard of truth in subjects with idiopathic normal pressure hydrocephalus

Leinonen V, Rinne JO, Wong DF, Wolk DA, Trojanowski JQ, Sherwin PF, Smith A, Heurling K, Su M, Grachev ID. 2014. Acta neuropathologica communications. 2: 46

High-fat diet increases tau expression in the brain of T2DM and AD mice independently of peripheral metabolic status

Takalo M, Haapasalo A, Martiskainen H, Kurkinen KM, Koivisto H, Miettinen P, Khandelwal VK, Kemppainen S, Kaminska D, Mäkinen P, Leinonen V, Pihlajamäki J, Soininen H, Laakso M, Tanila H, Hiltunen M. 2014. Journal of nutritional biochemistry. 25: 634-641

Increased y-Secretase Activity in Idiopathic Normal Pressure Hydrocephalus Patients with b-Amyloid Pathology

Laiterä T, Sarajärvi T, Haapasalo A, Puli L, Kauppinen T, Mäkinen P, Rauramaa T, Tanila H, Jääskeläinen JE, Alafuzoff I, Soininen H, Leinonen V, Hiltunen M. 2014. PLoS ONE. 3: 1-8

Preoperative MRI Findings Predict Two-Year Postoperative Clinical Outcome in Lumbar Spinal Stenosis

Kuittinen P, Sipola P, Leinonen V, Saari T, Sinikallio S, Savolainen S, Kröger H, Turunen V, Airaksinen O, Aalto T. 2014. PLoS ONE. 9: e106404

Transcriptomics and mechanistic elucidation of Alzheimer's disease risk genes in the brain and in vitro models

Martiskainen H, Viswanathan J, Nykänen NP, Kurki M, Helisalmi S, Natunen T, Sarajärvi T, Kurkinen KM, Pursiheimo JP, Rauramaa T, Alafuzoff I, Jääskeläinen JE, Leinonen V, Soininen H, Haapasalo A, Huttunen HJ, Hiltunen M. 2014. Neurobiology of aging. 36: 1221.e15-1221.e28

Visually assessed severity of lumbar spinal canal stenosis is paradoxically associated with leg pain and objective walking ability

Kuittinen Pekka, Sipola Petri, Saari Tapani, Aalto Timo Juhani, Sinikallio Sanna, Savolainen Sakari, Kröger Heikki, Turunen Veli, Leinonen Ville, Airaksinen Olavi. 2014. Bmc musculoskeletal disorders. 15: 348

Association of Modic changes with health-related quality of life among patients referred to spine surgery

Määttä J, Kautiainen H, Leinonen V, Niinimäki J, Järvenpää S, Koskelainen T, Mäkelä P, Pesälä J, Nyyssönen T, Savolainen S, Airaksinen O, Kyllönen E, Cheung KMC, Karppinen J. 2013. Scandinavian journal of pain. Volume 5: 36-40

Content validity and responsiveness of a Finnish version of the Patient-Specific Functional Scale

Lehtola V, Kaksonen A, Luomajoki H, Leinonen V, Gibbons S, Airaksinen O. 2013. European journal of physiotherapy. 15: 134-138

Education of research ethics for clinical investigators with Moodle tool

Halkoaho A, Matveinen M, Leinonen V, Luoto K, Keränen T. 2013. Bmc medical ethics. 14: 53

Effects of NR1H3 genetic variation on the expression of liver X receptor alfa and the progression of Alzheimer's Disease

Natunen Teemu, Martiskainen Henna, Sarajärvi Timo, Helisalmi Seppo, Pursiheimo Juha-Pekka, Viswanathan Jayashree, Laitinen Marjo, Kauppinen Tarja, Rauramaa Tuomas, Leinonen Ville, Alafuzoff Irina, Haapasalo Annakaisa, Soininen Hilkka, Hiltunen Mikko. 2013. PLoS ONE. 8: e80700

Influence of comorbidities in idiopathic normal pressure hydrocephalus - research and clinical care. A report of the ISHCSF task force on comorbidities in INPH.

Malm J, Graff-Radford NR, Ishikawa M, Kristensen B, Leinonen V, Mori E, Owler BK, Tullberg M, Williams MA, Relkin NR. 2013. Fluids and barriers of the cns. 10: 22

Poor cognitive outcome in shunt-responsive idiopathic normal pressure hydrocephalus

Koivisto AM, Alafuzoff I, Savolainen S, Sutela A, Rummukainen J, Kurki M, Jääskeläinen JE, Soininen H, Rinne J, Leinonen V,. 2013. Neurosurgery. 72: 1-8

Positron emission tomography with [18F]flutemetamol and [11C]PiB for in vivo detection of cerebral cortical amyloid in normal pressure hydrocephalus patients

Leinonen V, Rinne JO, Virtanen KA, Eskola O, Rummukainen J, Huttunen J, von Und Zu Fraunberg M, Nerg O, Koivisto AM, Rinne J, Jääskeläinen JE, Buckley C, Smith A, Jones PA, Sherwin P, Farrar G, McLain R, Kailajärvi M, Heurling K, Grachev ID. 2013. European journal of neurology. 20: 1043-52

Prospective Flutemetamol Positron Emission Tomography and Histopathology in Normal Pressure Hydrocephalus

Rinne JO, Frantzen J, Leinonen V, Lonnrot K, Laakso A, Virtanen KA, Solin O, Kotkansalo A, Koivisto A, Sajanti J, Karppinen A, Lehto H, Rummukainen J, Buckley C, Smith A, Jones PA, Sherwin P, Farrar G, McLain R, Kailajarvi M, Grachev ID. 2013. Neurodegenerative diseases. epub ahead of print: 9 sivua

APOE4 predicts amyloid-&#946 in cortical brain biopsy but not idiopathic normal pressure hydrocephalus

Pyykkö OT, Helisalmi S, Koivisto AM, Mölsä JA, Rummukainen J, Nerg O, Alafuzoff I, Savolainen S, Soininen H, Jääskeläinen JE, Rinne J, Leinonen V, Hiltunen M. 2012. Journal of neurology neurosurgery and psychiatry. 83: 1119-1124

Accuracy and reproducibility of a retrospective outcome assessement for lumbar spinal stenosis surgery

Kuittinen P, Aalto T, Heikkilä T, Leinonen V, Savolainen S, Sipola P, Kröger H, Turunen V, Airaksinen O. 2012. Bmc musculoskeletal disorders. 13: 83

CSF biomarkers for Alzheimer disease correlate with cortical brain biopsy findings

Seppälä TT, Nerg O, Koivisto AM, Rummukainen J, Puli L, Zetterberg H, Pyykkö OT, Helisalmi S, Alafuzoff I, Hiltunen M, Jääskeläinen JE, Rinne J, Soininen H, Leinonen V, Herukka S-K. 2012. Neurology. 78: 1568-1575

Cortical brain biopsy in long-term prognostication of 468 patients with possible normal pressure hydrocephalus

Leinonen V, Koivisto AM, Alafuzoff I, Pyykkö OT, Rummukainen J, von Und Zu Fraunberg M, Jääskeläinen JE, Soininen H, Rinne J, Savolainen S. 2012. Neurodegenerative diseases. 10: 166-169

Efficacy of movement control exercises versus general exercises on recurrent sub-acute nonspecific low back pain in a sub-group of patients with movement control dysfunction. Protocol of a randomized controlled trial.

Lehtola V, Luomajoki H, Leinonen V, Gibbons S, Airaksinen O. 2012. Bmc musculoskeletal disorders. 13: 55: 1-9

Lumbar paraspinal and biceps brachii muscle function and movement perception in lumbar spinal stenosis

Kääriäinen T, Leinonen V, Taimela S, Aalto T, Kröger H, Herno A, Turunen V, Savolainen S, Kankaanpää M, Airaksinen O. 2012. European spine journal. 2012: 6 sivua

Post-mortem findings in 10 patients with presumed normal-pressure hydrocephalus and review of the literature

Leinonen V, Koivisto AM, Savolainen S, Rummukainen J, Sutela A, Vanninen R, Jääskeläinen JE, Soininen H, Alafuzoff I. 2012. Neuropathology and applied neurobiology. 38: 72-86

Preoperative predictors for good postoperative satisfaction and functional outcome in lumbar spinal stenosis surgery - A prospective observational study with a two-year follow-up

Aalto T, Sinikallio S, Kröger H, Viinamäki H, Herno A, Leinonen V, Turunen V, Savolainen S, Airaksinen O. 2012. Scandinavian journal of surgery. 101: 255-260

[(18)F]Flutemetamol PET imaging and cortical biopsy histopathology for fibrillar amyloid &#946 detection in living subjects with normal pressure hydrocephalus: pooled analysis of four studies

Rinne JO, Wong DF, Wolk DA, Leinonen V, Arnold SE, Buckley C, Smith A, McLain R, Sherwin PF, Farrar G, Kailajärvi M, Grachev ID. 2012. Acta neuropathologica. 124: 833-845

Amyloid-beeta and Hyperphospholated Tau in the Prediction of Azheimer's Disease

Rummukainen J, Koivisto AM, Alafuzoff I, Leinonen V. 2011. European neurological review. 6: 84-88

Cerebrospinal Fluid Biomarkers in Idiopathic Normal Pressure Hydrocephalus

Leinonen V, Menon LG, Carroll RS, Dello Iacono D, Grevet J, Jääskeläinen JE, Black PM. 2011. International journal of alzheimers disease. 2011: 1-6

Postoperative rehabilitation does not improve functional outcome in lumbar spinal stenosis: a prospective study with 2-year postoperative follow-up

Aalto, Timo J; Leinonen, Ville; Herno, Arto; Alen, Markku; Kröger, Heikki; Turunen, Veli; Savolainen, Sakari; Saari, Tapani; Airaksinen, Olavi. 2011. European spine journal. 20: 1331-1340

Visual and quantitative assessment of lateral lumbar spinal canal stenosis with magnetic resonance imaging

Sipola P, Leinonen V, Niemeläinen R, Aalto T, Vanninen R, Manninen H, Airaksinen O, Battié MC. 2011. Acta radiologica. 52: 1024-1031

Muistisairaudet

Erkinjuntti T, Rinne J & Soininen H. 2010. . . WS Bookwell Oy

Assessment of beta-amyloid in a frontal cortical brain biopsy specimen and by positron emission tomography with carbon 11- labeled Pittsburgh compound B

Leinonen V, Alafuzoff I, Aalto S, Suotunen T, Savolainen S, Någren K, Tapiola T, Pirttilä T, Rinne J, Jääskeläinen JE, Soininen H, Rinne J, Pirttilä T, Soininen H. 2008. Archives of neurology. 65: 1304-1309

The amyloid beta-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae

Hansson Petersen CA, Alikhani N, Behbahani H, Wiehanger B, Pavlov PV, Alafuzoff I, Leinonen V, Ito A, Winbland B, Glaser E, Ankarcrona M. 2008. Proceedings of the National Academy of Sciences of the United States of America. 105: 13145-13150

Postural control in male patients with hip osteoarthritis

Arokoski JPA, Leinonen V, Arokoski MH, Aalto H, Valtonen H. 2006. Gait and posture. 23: 45-50

Back and neck extensor loading and back pain provocation in urban bus drivers with and without low back pain

Leinonen V, Kankaanpää M, Vanharanta H, Airaksinen O, Hänninen O. 2005. Pathophysiology. 12: 249-55

Indigenous healers' explanations of low back pain and its relief

Räsänen V, Leinonen V, Zaproudina N. 2005. Pathophysiology. 12: 313-316

Wireless on-line electromyography in recording neck muscle function: A pilot study

Airaksinen MK, Kankaanpää M, Aranko O, Leinonen V, Arokoski JPA, Airaksinen O. 2005. Pathophysiology. 12: 303-306

Lumbar paraspinal muscle function, perception of lumbar postition, and postural control in disc herniation-releted back pain

Leinonen V, Kankaanpää M, Luukonen M, Kansanen M, Hänninen O, Airaksinen O, Taimela S. 2003. Spine. 28: 842-848

Neuromuscular Control in Lumbar Disorders

Leinonen V. 2003. Kuopio University Publications D. Medical Sciences

Paraspinal muscle denervation, paradoxically good lumbar endurance, and an abnormal flexion-extension cycle in lumbar spinal stenosis

Leinonen V, Määttä S, Taimela S, Herno A, Kankaanpää M, Partanen J, Hänninen O, Airaksinen O. 2003. Spine. 28: 324-331

Impaired lumbar movement perception in association with postural stability and motor- and somatosensory-evoked potentials in lumbar spinal stenosis

Leinonen V, Määttä S, Taimela S, Herno A, Kankaanpää M, Partanen J, Kansanen M, Hänninen O, Airaksinen O. 2002. Spine. 27: 975-983

Disc herniation-related back pain impairs feed-forward control of paraspinal muscles

Leinonen V, Kankaanpää M, Luukkonen M, Hänninen O, Airaksinen O, Taimela S. 2001. Spine. 26: E367-E372

Back and hip extensor activities during trunk flexion/extension: effects of low back pain and rehabilitation

Leinonen V, Kankaanpää M, Airaksinen O, Hänninen O. 2000. Archives of physical medicine and rehabilitation. 81: 32-37

Research groups

Projects

Cerebrospinal Fluid Diagnostics of Alzheimer's Disease in Patients with Idiopathic Normal Pressure Hydrocephalus

Concordance of Alzheimer’s Disease-Related Biomarkers Between Intraventricular and Lumbar Cerebrospinal Fluid in Idiopathic Normal Pressure Hydrocephalus

Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro

Normaalipaineisen hydrokefaluksen arvoitus

Novel cerebrospinal fluid biomarkers correlating with shunt responsiveness in patients with idiopathic normal pressure hydrocephalus

Potent dual MAGL/FAAH inhibitor AKU-005 engages endocannabinoids to diminish meningeal nociception implicated in migraine pain

Protective Alzheimer's disease-associated APP A673T variant predominantly decreases sAPPβ levels in cerebrospinal fluid and 2D/3D cell culture models

Protocol of identical exercise programs with and without specific breathing techniques for the treatment of chronic non-specific low back pain: randomized feasibility trial with two-month follow-up

Reduced binding of apoE4 to complement factor H promotes amyloid‐β oligomerization and neuroinflammation

Serum Cathepsin S Levels Do Not Show Alterations in Different Clinical, Neuropathological, or Genetic Subtypes of Frontotemporal Dementia Patients nor in Comparison to Healthy Control Individuals

Cerebrospinal fluid biomarkers that reflect clinical symptoms in idiopathic normal pressure hydrocephalus patients

Computer-based Eye-tracking Analysis of King-Devick Test Differentiates Persons With Idiopathic Normal Pressure Hydrocephalus From Cognitively Unimpaired

Editorial: Toward a better understanding of the pathophysiology and clinical management of idiopathic normal pressure hydrocephalus

Genome-wide meta-analysis for Alzheimer’s disease cerebrospinal fluid biomarkers

In vivo assessment of Lewy body and beta-amyloid copathologies in idiopathic normal pressure hydrocephalus: prevalence and associations with clinical features and surgery outcome

Incidence and risk factors of spinal cord stimulation for persistent or recurrent pain after lumbar spine surgery: a population-based study

Kaularangan luisen juuriaukkoahtauman kirurginen hoito

Neuropathological findings in possible normal pressure hydrocephalus: A post-mortem study of 29 cases with lifelines

Postural sway does not differentiate individuals with chronic low back pain, single and multisite chronic musculoskeletal pain, or pain-free controls: a cross-sectional study of 229 subjects

Serum total TDP-43 levels are decreased in frontotemporal dementia patients with C9orf72 repeat expansion or concomitant motoneuron disease phenotype

Shortening of Saccades as a Possible Easy-to-Use Biomarker to Detect Risk of Alzheimer’s Disease

The effect of antithrombotic therapy on the recurrence and outcome of chronic subdural hematoma after burr-hole craniostomy in a population-based cohort

The effect of shunt surgery on corticospinal excitability in idiopathic normal pressure hydrocephalus: a transcranial magnetic stimulation study

5-Year health-related quality of life outcome in patients with idiopathic normal pressure hydrocephalus

A Novel Genetic Marker for the C9orf72 Repeat Expansion in the Finnish Population

Alzheimerin taudin uudet riskigeenit - keskiössä mikrogliasolut

Cerebrospinal fluid dynamics in idiopathic intracranial hypertension: a literature review and validation of contemporary findings

Cross-Cultural Adaptation, Reliability, and Psychophysical Validation of the Pain and Sleep Questionnaire Three-Item Index in Finnish

Cross-cultural adaptation and validation of the Finnish version of the central sensitization inventory and its relationship with dizziness and postural control

Elevated CSF LRG and Decreased Alzheimer's Disease Biomarkers in Idiopathic Normal Pressure Hydrocephalus

Ex Vivo Porcine Models Are Valid for Testing and Training Microsurgical Lumbar Decompression Techniques

FTLD Patient-Derived Fibroblasts Show Defective Mitochondrial Function and Accumulation of p62

Functional Characterization of Human Pluripotent Stem Cell-Derived Models of the Brain with Microelectrode Arrays

Gabapentinoids Associated With Lower Explantation Rate in 203 Patients With Spinal Cord Stimulation for Failed Back Surgery Syndrome

MECP2 Increases the Pro-Inflammatory Response of Microglial Cells and Phosphorylation at Serine 423 Regulates Neuronal Gene Expression upon Neuroinflammation

Plasma miR-9-3p and miR-136-3p as Potential Novel Diagnostic Biomarkers for Experimental and Human Mild Traumatic Brain Injury

Preoperative measurements on MRI in Chiari 1 patients fail to predict outcome after decompressive surgery

S327 phosphorylation of the presynaptic protein SEPTIN5 increases in the early stages of neurofibrillary pathology and alters the functionality of SEPTIN5

Shunt performance in 349 patients with hydrocephalus after aneurysmal subarachnoid hemorrhage

Surgically treated C1 fractures: a population-based study

The CERAD Neuropsychological Battery in Patients with Idiopathic Normal Pressure Hydrocephalus Compared with Normal Population and Patients with Mild Alzheimer's Disease

Time Trends of Cerebrospinal Fluid Biomarkers of Neurodegeneration in Idiopathic Normal Pressure Hydrocephalus

Upper limb dysfunction and activities in daily living in idiopathic normal pressure hydrocephalus

iNPH - the mystery resolving

Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-ß from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy

Corticospinal Excitability in Idiopathic Normal Pressure Hydrocephalus: A Transcranial Magnetic Stimulation Study

Diabetes is associated with familial idiopathic normal pressure hydrocephalus: a case-control comparison with family members

Diabetic phenotype in mouse and humans reduces the number of microglia around ß-amyloid plaques

Finnish Study of Intraoperative Irrigation Versus Drain Alone After Evacuation of Chronic Subdural Haematoma (FINISH): A Study Protocol for a Multicentre Randomised Controlled Trial

Higher Preimplantation Opioid Doses Associated With Long-Term Spinal Cord Stimulation Failure in 211 Patients With Failed Back Surgery Syndrome

LifeTime and improving European healthcare through cell-based interceptive medicine

Occurrence, Risk Factors, and Time Trends for Late Reoperations due to Degenerative Cervical Spine Disease: A Finnish National Register Study of 19 377 Patients Operated on Between 1999 and 2015

PTPR type Q in cerebrospinal fluid reflects ependymal cells dysfunction and is a potential biomarker for adult chronic hydrocephalus

Preoperative Predictors of Better Long-Term Functional Ability and Decreased Pain Following LSS Surgery: A Prospective Observational Study with a 10-year Follow-Up Period

Presynaptic Vesicle Protein SEPTIN5 Regulates the Degradation of APP C-Terminal Fragments and the Levels of Aß

Unfolding the outcomes of surgical treatment of lumbar spinal stenosis-a prospective 5- and 10-year follow-up study

Aivovammat

CSF biomarkers distinguish idiopathic normal pressure hydrocephalus from its mimics

Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology: A Systematic Review and Meta-analysis

Finnish Trial on Practices of Anterior Cervical Decompression and Fusion (FACADE): a protocol for a prospective randomised non-inferiority trial comparing outpatient versus inpatient care

MIM-Deficient Mice Exhibit Anatomical Changes in Dendritic Spines, Cortex Volume and Brain Ventricles, and Functional Changes in Motor Coordination and Learning

Normaalipaineisen hydrokefaluksen kliininen kuva, diagnostiset tutkimukset ja hoito

Predicting Development of Alzheimer's Disease in Patients with Shunted Idiopathic Normal Pressure Hydrocephalus

Prevalence of C9ORF72 Expansion in a Large Series of Patients with Idiopathic Normal-Pressure Hydrocephalus

Psychiatric disorders are a common prognostic marker for worse outcome in patients with idiopathic intracranial hypertension

Surgery for degenerative cervical spine disease in Finland, 1999-2015

Surgical techniques for degenerative cervical spine in Finland from 1999 to 2015

The Kuopio idiopathic normal pressure hydrocephalus protocol: initial outcome of 175 patients

[11C]PIB PET Is Associated with the Brain Biopsy Amyloid-ß Load in Subjects Examined for Normal Pressure Hydrocephalus

Aikuisten hydrokefalus ja sunttikomplikaatiot

Alterations in mitochondria-endoplasmic reticulum connectivity in human brain biopsies from idiopathic normal pressure hydrocephalus patients

Copy number loss in SFMBT1 is common among Finnish and Norwegian patients with iNPH

Ensihoidosta neurotehohoitoon

Incidence, comorbidities, and mortality in idiopathic normal pressure hydrocephalus

Interrelationship between the Levels of C9orf72 and Amyloid-ß Protein Precursor and Amyloid-ß in Human Cells and Brain Samples

Keskushermoston neurokirurgisesti hoidettavat infektiot

Keskushermoston toiminta ja häiriötilat