Ville Leinonen
Head of Department
Professor
School of Medicine, Faculty of Health Sciences
+358447172303
Research groups
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Brain Research Unit (BRU) - Clinical Trial Unit -
Clinical Epilepsy Research 01.01.2010 - -
NPH and Early AD 01.01.2010 - -
Pain Neuromodulation Group 01.01.2022 -
Projects
Publications
197/197 items-
A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer’s disease
Oh, Hamilton Se Hwee; Urey, Deniz Yagmur; Karlsson, Linda; Zhu, Zeyu; Shen, Yuanyuan; Farinas, Amelia; Timsina, Jigyasha; Duggan, Michael R.; Chen, Jingsha; Guldner, Ian H.; Morshed, Nader; Yang, Chengran; Western, Daniel; Ali, Muhammad; Le Guen, Yann; Trelle, Alexandra; Herukka, Sanna Kaisa; Rauramaa, Tuomas; Hiltunen, Mikko; Lipponen, Anssi; Luikku, Antti J.; Poston, Kathleen L.; Mormino, Elizabeth; Wagner, Anthony D.; Wilson, Edward N.; Channappa, Divya; Leinonen, Ville; Stevens, Beth; Ehrenb. 2025. Nature medicine. 31: 1592-1603 A1 Journal article (refereed), original research -
Ageing and higher BMI explain movement control impairment distinctly better than chronic pain and its contributing factors: A cross-sectional study of 161 subjects with chronic low back pain and 42 pain-free controls
Mikkonen, Jani; Reito, Aleksi; Luomajoki, Hannu; Airaksinen, Olavi; Takatalo, Jani; Pesonen, Janne; Leinonen, Ville. 2025. Journal of back and musculoskeletal rehabilitation. 38: 605-615 A1 Journal article (refereed), original research -
Altered tear fluid protein expression in persons with mild Alzheimer's disease in proteins involved in oxidative stress, protein synthesis, and energy metabolism
Kärkkäinen, Virve; Saari, Toni; Hannonen, Sanna; Rusanen, Minna; Lehtola, Juha-Matti; Uusitalo, Hannu; Leinonen, Ville; Thiede, Bernd; Kaarniranta, Kai; Koivisto, Anne M; Utheim, Tor P. 2025. Journal of Alzheimer's disease. 105: 292-301 A1 Journal article (refereed), original research -
Cerebrospinal fluid proteome profiling across the Alzheimer’s disease continuum: a step towards solving the equation for ‘X’
Weiner, Sophia; Sauer, Mathias; Montoliu-Gaya, Laia; Benedet, Andrea L; Ashton, Nicholas J; Gonzalez-Ortiz, Fernando; Simrén, Joel; Rahmouni, Nesrine; Tissot, Cecile; Therriault, Joseph; Servaes, Stijn; Stevenson, Jenna; Leinonen, Ville; Rauramaa, Tuomas; Hiltunen, Mikko; Rosa-Neto, Pedro; Blennow, Kaj; Zetterberg, Henrik; Gobom, Johan. 2025. Molecular neurodegeneration. 20: . 52 A1 Journal article (refereed), original research -
Effect of ventricular volume on cerebrospinal fluid Alzheimer's disease biomarkers in patients with idiopathic normal pressure hydrocephalus
Vanninen, Aleksi; Erkkilä, Lauri; Kokkola, Tarja; Selander, Tuomas; Koivisto, Anne M; Kokki, Merja; Musialowicz, Tadeusz; Lipponen, Anssi; Hiltunen, Mikko; Hakumäki, Juhana; Herukka, Sanna-Kaisa; Rauramaa, Tuomas; Leinonen, Ville. 2025. Journal of Alzheimer's disease. 105: 397-406 A1 Journal article (refereed), original research -
Failure to improve — identifying risk factors for poor functional recovery following chronic subdural hematoma surgery
Raj, Rahul; Tommiska, Pihla; Luoto, Teemu; Leinonen, Ville; Koivisto, Timo; Tetri, Sami; Posti, Jussi; Lönnrot, Kimmo. 2025. Age and ageing. 54: . afaf056 A1 Journal article (refereed), original research -
Inflammation-induced lysosomal dysfunction in human iPSC-derived microglia is exacerbated by APOE 4/4 genotype
Hellén, Marianna; Weert, Isabelle; Müller, Stephan A.; Räsänen, Noora; Kettunen, Pinja; Lehtonen, Šárka; Peitz, Michael; Fließbach, Klaus; Takalo, Mari; Koskuvi, Marja; Lichtenthaler, Stefan F.; Leinonen, Ville; Ramirez, Alfredo; Kärkkäinen, Olli; Hiltunen, Mikko; Koistinaho, Jari; Rõlova, Taisia. 2025. Journal of neuroinflammation. 22: . 147 A1 Journal article (refereed), original research -
Low prevalence of CWH43 variants among Finnish and Norwegian idiopathic normal pressure hydrocephalus patients: a cohort-based observational study
Räsänen, Joel; Helisalmi, Seppo; Heikkinen, Sami; Raivo, Joose; Korhonen, Ville E.; Martiskainen, Henna; Junkkari, Antti; Grenier-Boley, Benjamin; Bellenguez, Céline; Oinas, Minna; Avellan, Cecilia; Frantzen, Janek; Kotkansalo, Anna; Rinne, Jaakko; Ronkainen, Antti; Kauppinen, Mikko; von und zu Fraunberg, Mikael; Lönnrot, Kimmo; Satopää, Jarno; Perola, Markus; Koivisto, Anne M.; Julkunen, Valtteri; Portaankorva, Anne M.; Mannermaa, Arto; Soininen, Hilkka; Jääskeläinen, Juha E.; Lambert, Jean-Cha. 2025. Fluids and barriers of the cns. 22: . 17 A1 Journal article (refereed), original research -
Monoallelic TYROBP deletion is a novel risk factor for Alzheimer’s disease
Martiskainen, Henna; Willman, Roosa-Maria; Harju, Päivi; Heikkinen, Sami; Heiskanen, Mette; Müller, Stephan A.; Sinisalo, Rosa; Takalo, Mari; Mäkinen, Petra; Kuulasmaa, Teemu; Pekkala, Viivi; Galván del Rey, Ana; Juopperi, Sini-Pauliina; Jeskanen, Heli; Kervinen, Inka; Saastamoinen, Kirsi; Niiranen, Marja; Heikkinen, Sami V.; Kurki, Mitja I.; Marttila, Jarkko; Mäkinen, Petri I.; Rostalski, Hannah; Hietanen, Tomi; Ngandu, Tiia; Lehtisalo, Jenni; Bellenguez, Céline; Lambert, Jean-Charles; Haass, C. 2025. Molecular neurodegeneration. 20: . 50 A1 Journal article (refereed), original research -
Neuroinflammation Markers in Tear Fluid of Mild Alzheimer’s Disease
Kärkkäinen, Virve; Saari, Toni; Rusanen, Minna; Uusitalo, Hannu; Leinonen, Ville; Thiede, Bernd; Kaarniranta, Kai; Koivisto, Anne M.; Utheim, Tor P.. 2025. Journal of molecular neuroscience. 75: . 73 A1 Journal article (refereed), original research -
Outcome after Anterior Cervical Decompression and Fusion – A Nationwide FinSpine Register Study of Independent Predictors of Outcome at 12 Months after Surgery for Degenerative Cervical Spine
Klimko, Nikolai; Danner, Nils; Salo, Henri; Kotkansalo, Anna; Leinonen, Ville; Huttunen, Jukka. 2025. Spine. 50: 664-671 A1 Journal article (refereed), original research -
Outcome measures after anterior cervical decompression and fusion surgery -non-respondents do not bias the results: A Finnish spine register (FinSpine) study
Klimko, N; Danner, N; Salo, H; Malmivaara, A; Leinonen, V; Huttunen, J. 2025. Brain and spine. 5: A1 Journal article (refereed), original research -
Remote Monitoring Acceptance in Elderly Neurological Patients: Examining Sociodemographic Factors in the Pre-Implementation Phase
Zadegan, Melika Azim; Aromaa, Eeva; Sahlstrom, Rosa; Montonen, Tero; Eriksson, Päivi; Leinonen, Ville. 2025. Home health care management and practice. [Epub ahead of print March 12, 2025]: 1-7 A1 Journal article (refereed), original research -
Segment Anything for Dendrites from Electron Microscopy
Zhuo, Zewen; Belevich, Ilya; Leinonen, Ville; Jokitalo, Eija; Malm, Tarja; Sierra, Alejandra; Tohka, Jussi. Teoksessa: (toim.) , 2025. The Sixth IEEE International Image Processing, Applications and Systems Conference (IPAS'6) - Conference Proceedings. s. 1-6. IEEE A4 Conference proceedings -
The protective PLCγ2-P522R variant mitigates Alzheimer’s disease-associated pathologies by enhancing beneficial microglial functions
Takalo, Mari; Jeskanen, Heli; Rolova, Taisia; Kervinen, Inka; Hellén, Marianna; Heikkinen, Sami; Koivisto, Hennariikka; Jokivarsi, Kimmo; Müller, Stephan A.; Koivumäki, Esa-Mikko; Mäkinen, Petra; Juopperi, Sini-Pauliina; Willman, Roosa-Maria; Sinisalo, Rosa; Hoffmann, Dorit; Jäntti, Henna; Peitz, Michael; Fließbach, Klaus; Kuulasmaa, Teemu; Natunen, Teemu; Kemppainen, Susanna; Poutiainen, Pekka; Leinonen, Ville; Malm, Tarja; Martiskainen, Henna; Ramirez, Alfredo; Haapasalo, Annakaisa; Lichtentha. 2025. Journal of neuroinflammation. 22: . 64 A1 Journal article (refereed), original research -
Well-being in pain questionnaire: A novel, reliable, and valid tool for assessment of the personal well-being in individuals with chronic low back pain
Mikkonen, Jani; Martela, Frank; Holopainen, Riikka; Ekström, Kristian; Goubert, Liesbet; Leinonen, Ville; Selander, Tuomas; Airaksinen, Olavi; Neblett, Randy. 2025. Scandinavian journal of pain. 25: . 20240067 A1 Journal article (refereed), original research -
Ambulatory Care vs Overnight Hospitalization After Anterior Surgery for Cervical Radiculopathy
Lönnrot, Kimmo; Taimela, Simo; Satopää, Jarno; Saarenpää, Ilkka; Leinonen, Ville; Kivelev, Juri; Silvasti-Lundell, Marja; Förster, Johannes; Pitkänen, Mikko; Raj, Rahul; Kauppinen, Mikko; Westermarck, Riitta; Jahromi, Behnam Rezai; Koski-Palkén, Anniina; Seppälä, Matti; Kivipelto, Leena; Antinheimo, Jussi; Korja, Miikka; Czuba, Tomasz; Järvinen, Teppo L. N.. 2024. JAMA network open. 7: A1 Journal article (refereed), original research -
Burr-hole drainage with or without irrigation for chronic subdural haematoma (FINISH): a Finnish, nationwide, parallel-group, multicentre, randomised, controlled, non-inferiority trial
Raj, Rahul; Tommiska, Pihla; Koivisto, Timo; Leinonen, Ville; Danner, Nils; Posti, Jussi P; Laukka, Dan; Luoto, Teemu; Rauhala, Minna; Tetri, Sami; Korhonen, Tommi K; Satopää, Jarno; Kivisaari, Riku; Luostarinen, Teemu; Schwartz, Christoph; Czuba, Tomasz; Taimela, Simo; Lönnrot, Kimmo; Järvinen, Teppo L N; on behalf of the Finnish study of intraoperative irrigation versus drain alone after evacuation of CSDH (FINISH) study group. 2024. The Lancet. 403: 2798-2806 A1 Journal article (refereed), original research -
Considering the Potential Use of Oura Ring for Remote Monitoring at Home: The Perspective of Ageing Neurological Patients
Azim Zadegan, Melika; Sahlström, Rosa; Aromaa, Eeva; Montonen, Tero; Eriksson, Päivi; Leinonen, Ville. 2024. Communications in computer and information science abstract -
Deep learning assisted quantitative analysis of Aβ and microglia in patients with idiopathic normal pressure hydrocephalus in relation to cognitive outcome
Luikku, Antti J; Nerg, Ossi; Koivisto, Anne M; Hanninen, Tuomo; Junkkari, Antti; Kemppainen, Susanna; Juopperi, Sini-Pauliina; Sinisalo, Rosa; Pesola, Alli; Soininen, Hilkka; Hiltunen, Mikko; Leinonen, Ville; Rauramaa, Tuomas; Martiskainen, Henna. 2024. Journal of neuropathology and experimental neurology. 83: 967-978 A1 Journal article (refereed), original research -
Dimensionality, reliability, and validity of the Finnish version of the pain catastrophizing scale in chronic low back pain
Mikkonen, Jani; Leinonen, Ville; Lähdeoja, Tuomas; Holopainen, Riikka; Ekström, Kristian; Koho, Petteri; Airaksinen, Olavi; Luciano, Juan V; Navarrete, Jaime; Neblett, Randy. 2024. Scandinavian journal of pain. 24: . 20240034 A1 Journal article (refereed), original research -
Exploring the Association Between Visual Field Testing and CERAD Neuropsychological Battery in Idiopathic Normal Pressure Hydrocephalus Patients
Kemiläinen, Benjam; Tiainen, Sonja; Rauramaa, Tuomas; Luikku, Antti J; Herukka, Sanna-Kaisa; Koivisto, Anne; Hiltunen, Mikko; Verdooner, Steven; Johnson, Ken; Chambers, Mieko; Kaarniranta, Kai; Leinonen, Ville. 2024. Journal of Alzheimer's disease. 100: 247-260 A1 Journal article (refereed), original research -
Gut Microbiome Changes in Patients With Idiopathic Normal Pressure Hydrocephalus
Brandt, Emilia; Koivisto, Anne; Pereira, Pedro; Mustanoja, Ella; Auvinen, Petri; Saari, Toni; Lehtola, Juha-Matti; Hannonen, Sanna; Rusanen, Minna; Leinonen, Ville; Scheperjans, Filip; Kärkkäinen, Virve. 2024. Alzheimer disease and associated disorders. 38: 133-139 A1 Journal article (refereed), original research -
Human iPSC-derived pericyte-like cells carrying APP Swedish mutation overproduce beta-amyloid and induce cerebral amyloid angiopathy-like changes
Wu, Ying-Chieh; Lehtonen, Šárka; Trontti, Kalevi; Kauppinen, Riitta; Kettunen, Pinja; Leinonen, Ville; Laakso, Markku; Kuusisto, Johanna; Hiltunen, Mikko; Hovatta, Iiris; Freude, Kristine; Dhungana, Hiramani; Koistinaho, Jari; Rolova, Taisia. 2024. Fluids and barriers of the cns. 21: . 78 A1 Journal article (refereed), original research -
Identical movement control exercises with and without synchronized breathing for chronic non-specific low back pain:A randomized pilot trial
Mikkonen, Jani; Luomajoki, Hannu; Airaksinen, Olavi; Goubert, Liesbet; Pratscher, Steven; Leinonen, Ville. 2024. Journal of back and musculoskeletal rehabilitation. 37: 1561-1571 A1 Journal article (refereed), original research -
Optimizing Feature Selection for Unbalanced Metabolomics Data with A Background Factor: A Comparative Study in Parkinson's Disease
Zhang, Yinjia; Hämäläinen, Wilhelmiina; Reinikka, Paavo; Herukka, Sanna Kaisa; Leinonen, Ville; Lehtonen, Marko; Lehtonen, Šárka. Teoksessa: Cannataro, Mario; Zheng, Huiru (Jane); Gao, Lin; Cheng, Jianlin (Jack); de Miranda, João Luís; Zumpano, Ester; Hu, Xiaohua; Cho, Young-Rae; Park, Taesung(toim.) , 2024. Proceedings: 2024 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2024. s. 5884-5891. A4 Conference proceedings -
Outcome and complications of operatively treated subaxial cervical spine injuries: A population-based retrospective cohort study
Alve, Joel; Huttunen, Jukka; Leinonen, Ville; Jyrkkänen, Henna-Kaisa; Danner, Nils. 2024. World neurosurgery X. 22: A1 Journal article (refereed), original research -
Risk Variants Associated With Normal Pressure Hydrocephalus: Genome-Wide Association Study in the FinnGen Cohort
Räsänen, Joel; Heikkinen, Sami; Mäklin, Kiira; Lipponen, Anssi; Kuulasmaa, Teemu; Mehtonen, Juha; Korhonen, Ville E; Junkkari, Antti; Grenier-Boley, Benjamin; Bellenguez, Celine; Oinas, Minna; Avellan, Cecilia; Frantzén, Janek; Kotkansalo, Anna; Rinne, Jaakko; Ronkainen, Antti; Kauppinen, Mikko; von und zu Fraunberg, Mikael; Lönnrot, Kimmo; Satopää, Jarno; Perola, Markus; Koivisto, Anne M; Julkunen, Valtteri; Portaankorva, Anne M; Mannermaa, Arto; Soininen, Hilkka; Helisalmi, Seppo; Jääskeläinen. 2024. Neurology. 103: A1 Journal article (refereed), original research -
Tear fluid reflects the altered protein expressions of Alzheimer's disease patients in proteins involved in protein repair and clearance system or the regulation of cytoskeleton
Kärkkäinen, V; Hannonen, S; Rusanen M; Lehtola, JM; Saari, T; Uusitalo, H; Leinonen, V; Thiede, B; Kaarniranta, K; Koivisto, AM; Utheim, T. 2024. Journal of Alzheimer's disease. [First published online November 18, 2024]: 1-8 A1 Journal article (refereed), original research -
Utility of cortical tissue analysis in normal pressure hydrocephalus
Greenberg, Ana B. W.; Mekbib, Kedous Y.; Mehta, Neel H.; Kiziltug, Emre; Duy, Phan Q.; Smith, Hannah R.; Junkkari, Antti; Leinonen, Ville; Hyman, Bradley T.; Chan, Diane; Curry Jr, William T.; Arnold, Steven E.; Barker II, Frederick G.; Frosch, Matthew P.; Kahle, Kristopher T.. 2024. Cerebral cortex. 34: A1 Journal article (refereed), original research -
Ventriculoperitoneal shunt patients and glaucoma: a cohort analysis of the NPH registry
Kemiläinen, Benjam; Kaarniranta, Kai; Leinonen, Ville. 2024. Fluids and barriers of the cns. 21: . 54 A1 Journal article (refereed), original research -
Cerebrospinal Fluid Diagnostics of Alzheimer's Disease in Patients with Idiopathic Normal Pressure Hydrocephalus
Vanninen, Aleksi; Lukkarinen, Heikki; Kokkola, Tarja; Koivisto, Anne M.; Kokki, Merja; Musialowicz, Tadeusz; Hiltunen, Mikko; Zetterberg, Henrik; Leinonen, Ville; Herukka, Sanna Kaisa; Rauramaa, Tuomas. 2023. Journal of Alzheimer's disease. 94: 727-736 A1 Journal article (refereed), original research -
Concordance of Alzheimer’s Disease-Related Biomarkers Between Intraventricular and Lumbar Cerebrospinal Fluid in Idiopathic Normal Pressure Hydrocephalus
Lukkarinen, Heikki; Vanninen, Aleksi; Tesseur, Ina; Pemberton, Darrel; Van Der Ark, Peter; Kokkola, Tarja; Herukka, Sanna-Kaisa; Rauramaa, Tuomas; Hiltunen, Mikko; Blennow, Kaj; Zetterberg, Henrik; Leinonen, Ville. 2023. Journal of Alzheimer's disease. 91: 305-319 A1 Journal article (refereed), original research -
Early Alzheimer's disease pathology in human cortex involves transient cell states
Gazestani, Vahid; Kamath, Tushar; Nadaf, Naeem M; Dougalis, Antonios; Burris, SJ; Rooney, Brendan; Junkkari, Antti; Vanderburg, Charles; Pelkonen, Anssi; Gomez-Budia, Mireia; Välimäki, Nelli Noora; Rauramaa, Tuomas; Therrien, Martine; Koivisto, Anne M; Tegtmeyer, Matthew; Herukka, Sanna Kaisa; Abdulraouf, Abdulraouf; Marsh, Samuel E; Hiltunen, Mikko; Nehme, Ralda; Malm, Tarja; Stevens, Beth; Leinonen, Ville; Macosko, Evan Z. 2023. Cell. 186: 4438-4453.e23 A1 Journal article (refereed), original research -
Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro
Dolan, Michael-John; Therrien, Martine; Jereb, Saša; Kamath, Tushar; Gazestani, Vahid; Atkeson, Trevor; Marsh, Samuel E.; Goeva, Aleksandrina; Lojek, Neal M.; Murphy, Sarah; White, Cassandra M.; Joung, Julia; Liu, Bingxu; Limone, Francesco; Eggan, Kevin; Hacohen, Nir; Bernstein, Bradley E.; Glass, Christopher K.; Leinonen, Ville; Blurton-Jones, Mathew; Zhang, Feng; Epstein, Charles B.; Macosko, Evan Z.; Stevens, Beth. 2023. Nature immunology. 24: 1382-1390 A1 Journal article (refereed), original research -
Normaalipaineisen hydrokefaluksen arvoitus
Leinonen, Ville; Hiltunen, Mikko. 2023. Duodecim. 139: 340-342 D1 Article in a trade journal -
Novel cerebrospinal fluid biomarkers correlating with shunt responsiveness in patients with idiopathic normal pressure hydrocephalus
Weiner, Sophia; Junkkari, Antti; Sauer, Mathias; Luikku, Antti; Rauramaa, Tuomas; Kokkola, Tarja; Herukka, Sanna-Kaisa; Blennow, Kaj; Zetterberg, Henrik; Leinonen, Ville; Gobom, Johan. 2023. Fluids and barriers of the cns. 20: . 40 A1 Journal article (refereed), original research -
Operative Treatment of Tarlov Cysts - Outcomes and Predictors of Improvement after Surgery: A Series of 97 Consecutive Patients and a Systematic Review of Literature
Abdi, Delshad; Huttunen, Jukka; Leinonen, Ville; Savolainen, Sakari; Danner, Nils. 2023. Global spine journal. [Epub ahead of print 9 Dec 2023]: 1-8 A1 Journal article (refereed), original research -
Potent dual MAGL/FAAH inhibitor AKU-005 engages endocannabinoids to diminish meningeal nociception implicated in migraine pain
Della Pietra, Adriana; Krivoshein, Georgii; Ivanov, Konstantin; Giniatullina, Raisa; Jyrkkänen, Henna-Kaisa; Leinonen, Ville; Lehtonen, Marko; van den Maagdenberg, Arn MJM; Savinainen, Juha; Giniatullin, Rashid. 2023. Journal of headache and pain. 24: . 38 A1 Journal article (refereed), original research -
Protective Alzheimer's disease-associated APP A673T variant predominantly decreases sAPPβ levels in cerebrospinal fluid and 2D/3D cell culture models
Wittrahm, Rebekka; Takalo, Mari; Kuulasmaa, Teemu; Mäkinen, Petra M; Mäkinen, Petri; Končarević, Saša; Fartzdinov, Vadim; Selzer, Stefan; Kokkola, Tarja; Antikainen, Leila; Martiskainen, Henna; Kemppainen, Susanna; Marttinen, Mikael; Jeskanen, Heli; Rostalski, Hannah; Rahunen, Eija; Kivipelto, Miia; Ngandu, Tiia; Natunen, Teemu; Lambert, Jean-Charles; Tanzi, Rudolph E; Kim, Doo Yeon; Rauramaa, Tuomas; Herukka, Sanna-Kaisa; Soininen, Hilkka; Laakso, Markku; Pike, Ian; Leinonen, Ville; Haapasalo, . 2023. Neurobiology of disease. 182: A1 Journal article (refereed), original research -
Protocol of identical exercise programs with and without specific breathing techniques for the treatment of chronic non-specific low back pain: randomized feasibility trial with two-month follow-up
Mikkonen, Jani; Luomajoki, Hannu; Airaksinen, Olavi; Goubert, Liesbet; Leinonen, Ville. 2023. Bmc musculoskeletal disorders. 24: . 354 A1 Journal article (refereed), original research -
Reduced binding of apoE4 to complement factor H promotes amyloid‐β oligomerization and neuroinflammation
Chernyaeva, Larisa; Ratti, Giorgio; Teirilä, Laura; Fudo, Satoshi; Rankka, Uni; Pelkonen, Anssi; Korhonen, Paula; Leskinen, Katarzyna; Keskitalo, Salla; Salokas, Kari; Gkolfinopoulou, Christina; Crompton, Katrina E; Javanainen, Matti; Happonen, Lotta; Varjosalo, Markku; Malm, Tarja; Leinonen, Ville; Chroni, Angeliki; Saavalainen, Päivi; Meri, Seppo; Kajander, Tommi; Wollman, Adam JM; Nissilä, Eija; Haapasalo, Karita. 2023. Embo reports. 24: A1 Journal article (refereed), original research -
Serum Cathepsin S Levels Do Not Show Alterations in Different Clinical, Neuropathological, or Genetic Subtypes of Frontotemporal Dementia Patients nor in Comparison to Healthy Control Individuals
Heikkinen, Sami; Huber, Nadine; Katisko, Kasper; Kokkola, Tarja; Hartikainen, Päivi; Krüger, Johanna; Leinonen, Ville; Korhonen, Ville E; Herukka, Sanna-Kaisa; Remes, Anne M; Borroni, Barbara; Alberici, Antonella; Libri, Ilenia; Solje, Eino; Haapasalo, Annakaisa. 2023. Journal of Alzheimer's disease. 93: 395-401 A1 Journal article (refereed), original research -
To what degree patient-reported symptoms of central sensitization, kinesiophobia, disability, sleep, and life quality associated with 24-h heart rate variability and actigraphy measurements?
Mikkonen, Jani; Kupari; Saana; Tarvainen, Mika; Neblett, Randy; Airaksinen, Olavi; Luomajoki, Hannu; Leinonen, Ville. 2023. Pain practice. 2024; 24: 609-619 A1 Journal article (refereed), original research -
Cerebrospinal fluid biomarkers that reflect clinical symptoms in idiopathic normal pressure hydrocephalus patients
Lukkarinen, Heikki; Jeppsson, Anna; Wikkelsö, Carsten; Blennow, Kaj; Zetterberg, Henrik; Constantinescu, Radu; Remes, Anne M.; Herukka, Sanna-Kaisa; Hiltunen, Mikko; Rauramaa, Tuomas; Nägga, Katarina; Leinonen, Ville; Tullberg, Mats. 2022. Fluids and barriers of the cns. 19: . 11 A1 Journal article (refereed), original research -
Computer-based Eye-tracking Analysis of King-Devick Test Differentiates Persons With Idiopathic Normal Pressure Hydrocephalus From Cognitively Unimpaired
Lehtola, Juha-Matti; Kärkkäinen, Virve; Andberg, Sami; Hannonen, Sanna; Rusanen, Minna; Saari, Toni; Korhonen, Ville; Hokkanen, Laura; Hallikainen, Merja; Hänninen, Tuomo; Kaarniranta, Kai; Bednarik, Roman; Leinonen, Ville; Koivisto, Anne M. 2022. Alzheimer disease and associated disorders. 36: 340-346 A1 Journal article (refereed), original research -
Editorial: Toward a better understanding of the pathophysiology and clinical management of idiopathic normal pressure hydrocephalus
Karagiozov, Kostadin L.; Leinonen, Ville; Miyajima, Masakazu; Nakajima, Madoka. 2022. Frontiers in neurology. 13: . 1013720 B1 Non-refereed journal articles -
Genome-wide meta-analysis for Alzheimer’s disease cerebrospinal fluid biomarkers
Jansen, Iris E.; van der Lee, Sven J.; Gomez-Fonseca, Duber; de Rojas, Itziar; Dalmasso, Maria Carolina; Grenier-Boley, Benjamin; Zettergren, Anna; Mishra, Aniket; Ali, Muhammad; Andrade, Victor; Bellenguez, Céline; Kleineidam, Luca; Küçükali, Fahri; Sung, Yun Ju; Tesí, Niccolo; Vromen, Ellen M.; Wightman, Douglas P.; Alcolea, Daniel; Alegret, Montserrat; Alvarez, Ignacio; Amouyel, Philippe; Athanasiu, Lavinia; Bahrami, Shahram; Bailly, Henri; Belbin, Olivia; Bergh, Sverre; Bertram, Lars; Biesse. 2022. Acta neuropathologica. 144: 821-842 A1 Journal article (refereed), original research -
In vivo assessment of Lewy body and beta-amyloid copathologies in idiopathic normal pressure hydrocephalus: prevalence and associations with clinical features and surgery outcome
Giannini, Giulia; Baiardi, Simone; Dellavalle, Sofia; Zenesini, Corrado; Cevoli, Sabina; Danner, Nils; Jyrkkänen, Henna-Kaisa; Rossi, Marcello; Polischi, Barbara; Quadalti, Corinne; Stefanini, Camilla; Cortelli, Pietro; Milletti, David; Herukka, Sanna-Kaisa; Palandri, Giorgio; Leinonen, Ville; Parchi, Piero. 2022. Fluids and barriers of the cns. 19: . 71 A1 Journal article (refereed), original research -
Incidence and risk factors of spinal cord stimulation for persistent or recurrent pain after lumbar spine surgery: a population-based study
Huttunen, Jukka; Fraunberg, Mikael von und zu; Ikäheimo, Tiina-Mari; Jyrkkänen, Henna-Kaisa; Nissen, Mette; Leinonen, Ville; Salmenkivi, Jyrki; Malmivaara, Antti; Sirola, Joonas; Sund, Reijo. 2022. Acta neurochirurgica. 164: 2645-2653 A1 Journal article (refereed), original research -
Kaularangan luisen juuriaukkoahtauman kirurginen hoito
Kotkansalo, Anna; Leinonen, Ville; Korhonen, Katariina; Rinne, Jaakko; Malmivaara, Antti . 2022. Duodecim. 138: 769-777 A2 Review article, Literature review, Systematic review -
Neuropathological findings in possible normal pressure hydrocephalus: A post-mortem study of 29 cases with lifelines
Hänninen, JJ; Nakajima, M; Vanninen, A; Hytönen, S; Rummukainen, J; Koivisto, AM; Jääskeläinen, JE; Soininen, H; Sutela, A; Vanninen, R; Hiltunen, M; Leinonen, V; Rauramaa, T. 2022. Free neuropathology. 3: 1-17 A1 Journal article (refereed), original research -
Postural sway does not differentiate individuals with chronic low back pain, single and multisite chronic musculoskeletal pain, or pain-free controls: a cross-sectional study of 229 subjects
Mikkonen, Jani; Leinonen, Ville; Kaski, Diego; Hartvigsen, Jan; Luomajoki, Hannu; Selander, Tuomas; Airaksinen, Olavi. 2022. Spine journal. 22: 1523-1534 A1 Journal article (refereed), original research -
Serum total TDP-43 levels are decreased in frontotemporal dementia patients with C9orf72 repeat expansion or concomitant motoneuron disease phenotype
Katisko, Kasper; Huber, Nadine; Kokkola, Tarja; Hartikainen, Päivi; Krüger, Johanna; Heikkinen, Anna-Leena; Paananen, Veera; Leinonen, Ville; Korhonen, Ville E.; Helisalmi, Seppo; Herukka, Sanna-Kaisa; Cantoni, Valentina; Gadola, Yasmine; Archetti, Silvana; Remes, Anne M.; Haapasalo, Annakaisa; Borroni, Barbara; Solje, Eino. 2022. Alzheimer's research and therapy. 14: . 151 A1 Journal article (refereed), original research -
Shortening of Saccades as a Possible Easy-to-Use Biomarker to Detect Risk of Alzheimer’s Disease
Hannonen, Sanna; Andberg, Sami; Kärkkäinen, Virve; Rusanen, Minna; Lehtola, Juha-Matti; Saari, Toni; Korhonen, Ville; Hokkanen, Laura; Hallikainen, Merja; Hänninen, Tuomo; Leinonen, Ville; Kaarniranta, Kai; Bednarik, Roman; Koivisto, Anne M.. 2022. Journal of Alzheimer's disease. 88: 609-618 A1 Journal article (refereed), original research -
The effect of antithrombotic therapy on the recurrence and outcome of chronic subdural hematoma after burr-hole craniostomy in a population-based cohort
Kerttula, Santtu; Huttunen, Jukka; Leinonen, Ville; Kämäräinen, Olli Pekka; Danner, Nils. 2022. Acta neurochirurgica. 164: 2699-2708 A1 Journal article (refereed), original research -
The effect of shunt surgery on corticospinal excitability in idiopathic normal pressure hydrocephalus: a transcranial magnetic stimulation study
Sirkka, Jani; Säisänen, Laura; Julkunen, Petro; Könönen, Mervi; Kallioniemi, Elisa; Leinonen, Ville; Danner, Nils. 2022. Fluids and barriers of the cns. 19: . 89 A1 Journal article (refereed), original research -
5-Year health-related quality of life outcome in patients with idiopathic normal pressure hydrocephalus
Junkkari, A; Sintonen, H; Danner, N; Jyrkkänen, HK; Rauramaa, T; Luikku, AJ; Koivisto, AM; Roine, RP; Viinamäki, H; Soininen, H; Jääskeläinen, JE; Leinonen, V. 2021. Journal of neurology. 268: 3283-3293 A1 Journal article (refereed), original research -
A Novel Genetic Marker for the C9orf72 Repeat Expansion in the Finnish Population
Rostalski, H; Korhonen, V; Kuulasmaa, T; Solje, E; Krüger, J; Gen, F; Kaivola, K; Eide, PK; Lambert, JC; Julkunen, V; Tienari, PJ; Remes, AM; Leinonen, V; Hiltunen, M; Haapasalo, A. 2021. Journal of Alzheimer's disease. 83: 1325-1332 A1 Journal article (refereed), original research -
Alzheimerin taudin uudet riskigeenit - keskiössä mikrogliasolut
Martiskainen, Henna; Takalo, Mari; Konttinen, Henna; Malm, Tarja; Haapasalo, Annakaisa; Leinonen, Ville; Hiltunen, Mikko. 2021. Duodecim. 137: 1375- 1382 A2 Review article, Literature review, Systematic review -
Cerebrospinal fluid dynamics in idiopathic intracranial hypertension: a literature review and validation of contemporary findings
Kaipainen, Aku L; Martoma, Erik; Puustinen, Tero; Tervonen, Joona; Jyrkkänen, Henna-Kaisa; Paterno, Jussi J; Kotkansalo, Anna; Rantala, Susanna; Vanhanen, Ulla; Leinonen, Ville; Lehto, Soili M; Iso-Mustajärvi, Matti; Elomaa, Antti-Pekka; Qvarlander, Sara; Huuskonen, Terhi J. 2021. Acta neurochirurgica. 163: 3353-3368 A2 Review article, Literature review, Systematic review -
Cross-Cultural Adaptation, Reliability, and Psychophysical Validation of the Pain and Sleep Questionnaire Three-Item Index in Finnish
Mikkonen, Jani; Leinonen, Ville; Luomajoki, Hannu; Kaski, Diego; Kupari, Saana; Tarvainen, Mika; Selander, Tuomas; Airaksinen, Olavi. 2021. Journal of clinical medicine. 10: 4887 A1 Journal article (refereed), original research -
Cross-cultural adaptation and validation of the Finnish version of the central sensitization inventory and its relationship with dizziness and postural control
Mikkonen, Jani; Luomajoki, Hannu; Airaksinen, Olavi; Neblett, Randy; Selander, Tuomas; Leinonen, Ville. 2021. Bmc neurology. 21: 141 A1 Journal article (refereed), original research -
Elevated CSF LRG and Decreased Alzheimer's Disease Biomarkers in Idiopathic Normal Pressure Hydrocephalus
Vanninen, Aleksi; Nakajima, Madoka; Miyajima, Masakazu; Rauramaa, Tuomas; Kokki, Merja; Musialowicz, Tadeusz; Mäkinen, Petra M; Herukka, Sanna-Kaisa; Koivisto, Anne M; Jääskeläinen, Juha E; Hiltunen, Mikko; Leinonen, Ville. 2021. Journal of clinical medicine. 10: 1105 A1 Journal article (refereed), original research -
Ex Vivo Porcine Models Are Valid for Testing and Training Microsurgical Lumbar Decompression Techniques
Säteri, Tuomas; Nurro, Jussi; Hätinen, Olli-Pekka; Hakulinen, Mikko; Leinonen, Ville; Elomaa, Antti-Pekka. 2021. World neurosurgery. 155: e64-e74 A1 Journal article (refereed), original research -
FTLD Patient-Derived Fibroblasts Show Defective Mitochondrial Function and Accumulation of p62
Leskelä, S; Hoffmann, D; Rostalski, H; Huber, N; Wittrahm, R; Hartikainen, P; Korhonen, V; Leinonen, V; Hiltunen, M; Solje, E; Remes, AM; Haapasalo, A. 2021. Molecular neurobiology. 58: 5438-5458 A1 Journal article (refereed), original research -
Functional Characterization of Human Pluripotent Stem Cell-Derived Models of the Brain with Microelectrode Arrays
Pelkonen, Anssi; Pistono, Cristiana; Klecki, Pamela; Gómez-Budia, Mireia; Dougalis, Antonios; Konttinen, Henna; Stanová, Iveta; Fagerlund, Ilkka; Leinonen, Ville; Korhonen, Paula; Malm, Tarja. 2021. Cells. 2022; 11: 106 A2 Review article, Literature review, Systematic review -
Gabapentinoids Associated With Lower Explantation Rate in 203 Patients With Spinal Cord Stimulation for Failed Back Surgery Syndrome
Nissen, Mette; Ikäheimo, Tiina-Mari; Huttunen, Jukka; Leinonen, Ville; Jyrkkänen, Henna-Kaisa; von und zu Fraunberg, Mikael. 2021. Neurosurgery. 89: 626-634 A1 Journal article (refereed), original research -
MECP2 Increases the Pro-Inflammatory Response of Microglial Cells and Phosphorylation at Serine 423 Regulates Neuronal Gene Expression upon Neuroinflammation
Wittrahm, Rebekka; Takalo, Mari; Marttinen, Mikael; Kuulasmaa, Teemu; Mäkinen, Petra; Kemppainen, Susanna; Martiskainen, Henna; Rauramaa, Tuomas; Pike, Ian; Leinonen, Ville; Natunen, Teemu; Haapasalo, Annakaisa; Hiltunen, Mikko. 2021. Cells. 10: 860 A1 Journal article (refereed), original research -
Plasma miR-9-3p and miR-136-3p as Potential Novel Diagnostic Biomarkers for Experimental and Human Mild Traumatic Brain Injury
Das Gupta, Shalini; Ciszek, Robert; Heiskanen, Mette; Lapinlampi, Niina; Kukkonen, Janne; Leinonen, Ville; Puhakka, Noora; Pitkänen, Asla. 2021. International journal of molecular sciences. 22: 1563 A1 Journal article (refereed), original research -
Preoperative measurements on MRI in Chiari 1 patients fail to predict outcome after decompressive surgery
Jussila, Miro-Pekka; Nissilä, Juho; Vakkuri, Minna; Olsén, Päivi; Niinimäki, Jaakko; Leinonen, Ville; Serlo, Willy; Salokorpi, Niina; Suo-Palosaari, Maria. 2021. Acta neurochirurgica. [Epub ahead of print 11 May 2021]: 1-10 A1 Journal article (refereed), original research -
S327 phosphorylation of the presynaptic protein SEPTIN5 increases in the early stages of neurofibrillary pathology and alters the functionality of SEPTIN5
Ferreira, Catarina B.; Marttinen, Mikael; Coelho, Joana E.; Paldanius, Kaisa M.A.; Takalo, Mari; Mäkinen, Petra; Leppänen, Luukas; Miranda-Lourenço, Catarina; Fonseca-Gomes, João; Tanqueiro, Sara R.; Vaz, Sandra H.; Belo, Rita F.; Sebastião, Ana Maria; Leinonen, Ville; Soininen, Hilkka; Pike, Ian; Haapasalo, Annakaisa; Lopes, Luísa V.; de Mendonça, Alexandre; Diógenes, Maria José; Hiltunen, Mikko. 2021. Neurobiology of disease. 2022; 163: 105603 A1 Journal article (refereed), original research -
Shunt performance in 349 patients with hydrocephalus after aneurysmal subarachnoid hemorrhage
Tervonen, Joona; Adams, Hadie; Lindgren, Antti; Elomaa, Antti-Pekka; Kämäräinen, Olli-Pekka; Kärkkäinen, Virve; von und zu Fraunberg, Mikael; Huttunen, Jukka; Koivisto, Timo; Jääskeläinen, Juha E.; Leinonen, Ville; Huuskonen, Terhi J.. 2021. Acta neurochirurgica. 163: 2703-2714 A1 Journal article (refereed), original research -
Surgically treated C1 fractures: a population-based study
Ylönen, Henri; Danner, Nils; Jyrkkänen, Henna-Kaisa; Kämäräinen, Olli-Pekka; Leinonen, Ville; Huttunen, Jukka. 2021. World neurosurgery. 154: e333-e342 A1 Journal article (refereed), original research -
The CERAD Neuropsychological Battery in Patients with Idiopathic Normal Pressure Hydrocephalus Compared with Normal Population and Patients with Mild Alzheimer's Disease
Nerg, Ossi; Junkkari, Antti; Hallikainen, Ilona; Rauramaa, Tuomas; Luikku, Antti; Hiltunen, Mikko; Jääskeläinen, Juha E.; Leinonen, Ville; Hänninen, Tuomo; Koivisto, Anne;. 2021. Journal of Alzheimer's disease. 81: 1117-1130 A1 Journal article (refereed), original research -
Time Trends of Cerebrospinal Fluid Biomarkers of Neurodegeneration in Idiopathic Normal Pressure Hydrocephalus
Lukkarinen, Heikki; Tesseur, Ina; Pemberton, Darrel; Van Der Ark, Peter; Timmers, Maarten; Slemmon, Randy; Janssens, Luc; Streffer, Johannes; Van Nueten, Luc; Bottelbergs, Astrid; Rauramaa, Tuomas; Koivisto, Anne M.; Herukka, Sanna-Kaisa; Korhonen, Ville E.; Junkkari, Antti; Hiltunen, Mikko; Engelborghs, Sebastiaan; Blennowk, Kaj; Zetterbergk, Henrik; Kolb, Hartmuth C.; Leinonen, Ville. 2021. Journal of Alzheimer's disease. 80: 1629-1642 A1 Journal article (refereed), original research -
Upper limb dysfunction and activities in daily living in idiopathic normal pressure hydrocephalus
Sirkka, Jani; Parviainen, Marita; Jyrkkänen, Henna-Kaisa; Koivisto, Anne M.; Säisänen, Laura; Rauramaa, Tuomas; Leinonen, Ville; Danner, Nils. 2021. Acta neurochirurgica. 163: 2675-2683 A1 Journal article (refereed), original research -
iNPH - the mystery resolving
Leinonen, Ville; Kuulasmaa, Teemu; Hiltunen, Mikko. 2021. Embo molecular medicine. 13: e13720 B1 Non-refereed journal articles -
Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-ß from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy
Carare, RO; Aldea, R; Agarwal, N; Bacskai, BJ; Bechman, I; Boche, D; Bu, G; Bulters, D; Clemens, A; Counts, SE; de Leon, M; Eide, PK; Fossati, S; Greenberg, SM; Hamel, E; Hawkes, CA; Koronyo-Hamaoui, M; Hainsworth, AH; Holtzman, D; Ihara, M; et al [incl. Kanninen, K; Leinonen, V; Malm, T]. 2020. Alzheimer's & dementia : diagnosis, assessment & disease monitoring. 21: e12053 A1 Journal article (refereed), original research -
Corticospinal Excitability in Idiopathic Normal Pressure Hydrocephalus: A Transcranial Magnetic Stimulation Study
Sirkka, J; Säisänen, L; Julkunen, P; Könönen, M; Kallioniemi, E; Leinonen, V; Danner, N. 2020. Fluids and barriers of the cns. 17: 6 A1 Journal article (refereed), original research -
Diabetes is associated with familial idiopathic normal pressure hydrocephalus: a case-control comparison with family members
Räsänen, Joel; Huovinen, Joel; Korhonen, Ville E; Junkkari, Antti; Kastinen, Sami; Komulainen, Simo; Oinas, Minna; Avellan, Cecilia; Frantzen, Janek; Rinne, Jaakko; Ronkainen, Antti; Kauppinen, Mikko; Lönnrot, Kimmo; Perola, Markus; Koivisto, Anne M; Remes, Anne M; Soininen, Hilkka; Hiltunen, Mikko; Helisalmi, Seppo; Kurki, Mitja I [et al. incl. Jääskeläinen, Juha E: Leinonen, Ville]. 2020. Fluids and barriers of the cns. 17: 57 A1 Journal article (refereed), original research -
Diabetic phenotype in mouse and humans reduces the number of microglia around ß-amyloid plaques
Natunen, Teemu; Martiskainen, Henna; Marttinen, Mikael; Gabbouj, Sami; Koivisto, Hennariikka; Kemppainen, Susanna; Kaipainen, Satu; Takalo, Mari; Svobodová, Helena; Leppänen, Luukas; Kemiläinen, Benjam; Ryhänen, Simo; Kuulasmaa, Teemu: Rahunen, Eija: Juutinen, Sisko; Mäkinen, Petra; Miettinen, Pasi; Rauramaa, Tuomas; Pihlajamäki, Jussi; Haapasalo, Annakaisa; et al [incl. Leinonen, Ville; Tanila, Heikki; Hiltunen, Mikko]. 2020. Molecular neurodegeneration. 15: 66 A1 Journal article (refereed), original research -
Finnish Study of Intraoperative Irrigation Versus Drain Alone After Evacuation of Chronic Subdural Haematoma (FINISH): A Study Protocol for a Multicentre Randomised Controlled Trial
Tommiska, P; Raj, R; Schwartz, C; Kivisaari, R; Luostarinen, T; Satopää, J; Taimela, S; Järvinen, T; Ranstam, J; Frantzen, J; Posti, J; Luoto, TM; Leinonen, V; Tetri, S; Koivisto, T; Lönnrot, K. 2020. BMJ open. 10: e038275 A1 Journal article (refereed), original research -
Higher Preimplantation Opioid Doses Associated With Long-Term Spinal Cord Stimulation Failure in 211 Patients With Failed Back Surgery Syndrome
Nissen, Mette; Ikäheimo, Tiina-Mari; Huttunen, Jukka; Leinonen, Ville; Jyrkkänen, Henna-Kaisa; von Und Zu Fraunberg, Mikael. 2020. Neuromodulation. 2021; 24: 102-111 A1 Journal article (refereed), original research -
LifeTime and improving European healthcare through cell-based interceptive medicine
Rajewsky, Nikolaus; Almouzni, Geneviève; Gorski, Stanislaw A; Aerts, Stein; Amit, Ido; Bertero, Michela G; Bock, Christoph; Bredenoord, Annelien L; Cavalli, Giacomo; Chiocca, Susanna; Clevers, Hans; Strooper, Bart De; Eggert, Angelika; Ellenberg, Jan; Fernández, Xosé M; Figlerowicz, Marek; Gasser, Susan M; Hubner, Norbert; Kjems, Jørgen; Knoblich, Jürgen A et al. [incl. Pitkänen, Asla; Leinonen, Ville]. 2020. Nature. 587: 377-386 A1 Journal article (refereed), original research -
Occurrence, Risk Factors, and Time Trends for Late Reoperations due to Degenerative Cervical Spine Disease: A Finnish National Register Study of 19 377 Patients Operated on Between 1999 and 2015
Kotkansalo, Anna; Leinonen, Ville; Korajoki, Merja; Korhonen, Katariina; Rinne, Jaakko; Malmivaara, Antti. 2020. Neurosurgery. 2021; 88: 558-573 A1 Journal article (refereed), original research -
PTPR type Q in cerebrospinal fluid reflects ependymal cells dysfunction and is a potential biomarker for adult chronic hydrocephalus
Nakajima, Madoka; Rauramaa, Tuomas; Mäkinen, Petra M; Hiltunen, Mikko; Herukka, Sanna-Kaisa; Kokki, Merja; Musialowicz, Tadeusz; Jyrkkänen, Henna-Kaisa; Danner, Nils; Junkkari, Antti; Koivisto, Anne M; Jääskeläinen, Juha E; Miyajima, Masakazu; Ogino, Ikuko; Furuta, Akiko; Akiba, Chihiro; Kawamura, Kaito; Kamohara, Chihiro; Sugano, Hidenori; Tange, Yuichi; et al. [incl. Leinonen, Ville]. 2020. European journal of neurology. 2021; 28: 389-400 A1 Journal article (refereed), original research -
Preoperative Predictors of Better Long-Term Functional Ability and Decreased Pain Following LSS Surgery: A Prospective Observational Study with a 10-year Follow-Up Period
Tuomainen, I; Pesonen, J; Rade, M; Pakarinen, M; Leinonen, V; Kröger, H; Airaksinen, O; Aalto, T. 2020. Spine. 45: 776-783 A1 Journal article (refereed), original research -
Presynaptic Vesicle Protein SEPTIN5 Regulates the Degradation of APP C-Terminal Fragments and the Levels of Aß
Marttinen, Mikael; Ferreira, Catarina B; Paldanius, Kaisa M A; Takalo, Mari; Natunen, Teemu; Mäkinen, Petra; Leppänen, Luukas; Leinonen, Ville; Tanigaki, Kenji; Kang, Gina; Hiroi, Noboru; Soininen, Hilkka; Rilla, Kirsi; Haapasalo, Annakaisa; Hiltunen, Mikko. 2020. Cells. 9: 2482 A1 Journal article (refereed), original research -
Unfolding the outcomes of surgical treatment of lumbar spinal stenosis-a prospective 5- and 10-year follow-up study
Tuomainen, I; Aalto, T; Pesonen, J; Rade, M; Pakarinen, M; Leinonen, V; Kröger, H; Airaksinen, O. 2020. European spine journal. 29: 2231-2242 A1 Journal article (refereed), original research -
Aivovammat
Luoto, Teemu; Leinonen, Ville; Bendel, Stepani; Koivisto, Timo; Jääskeläinen, Juha E. Teoksessa: Leppäniemi, Ari; Kuokkanen, Hannu; Salminen, Pauliina(toim.) , 2019. Kirurgia. s. 892-905. Kustannus Oy Duodecim D2 Article in a professional book (incl. an introduction by the editor) -
CSF biomarkers distinguish idiopathic normal pressure hydrocephalus from its mimics
Jeppsson, Anna; Wikkelsö, Carsten; Blennow, Kaj; Zetterberg, Henrik; Constantinescu, Radu; Remes, Anne M; Herukka, Sanna-Kaisa; Rauramaa, Tuomas; Nagga, Katarina; Leinonen, Ville; Tullberg, Mats. 2019. Journal of neurology neurosurgery and psychiatry. 90: 1117-1123 A1 Journal article (refereed), original research -
Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology: A Systematic Review and Meta-analysis
Bridel, C; van Wieringen, WN; Zetterberg, H; Tijms, BM; Teunissen, CE; Alvarez-Cermeño, JC; Andreasson, U; Axelsson, M; Bäckström, DC; Bartos, A; Bjerke, M; Blennow, K; Boxer, A; Brundin, L; Burman, J; Christensen, T; Fialová, L; Forsgren, L; Frederiksen, JL; Gisslén, M; et al.; and the NFL Group (incl. Leinonen, V). 2019. JAMA neurology. 76: 1035-1048 A2 Review article, Literature review, Systematic review -
Finnish Trial on Practices of Anterior Cervical Decompression and Fusion (FACADE): a protocol for a prospective randomised non-inferiority trial comparing outpatient versus inpatient care
Lönnrot, Kimmo; Taimela, Simo; Toivonen, Pirjo; Aronen, Pasi; Koski-Palken, Anniina; Frantzen, Janek; Leinonen, Ville; Silvasti-Lundell, Marja; Förster, Johannes; Jarvinen, Teppo. 2019. BMJ open. 9: 1-8 A1 Journal article (refereed), original research -
MIM-Deficient Mice Exhibit Anatomical Changes in Dendritic Spines, Cortex Volume and Brain Ventricles, and Functional Changes in Motor Coordination and Learning
Minkeviciene R, Hlushchenko, I; Virenque, A; Lahti, L; Khanal, P; Rauramaa, T; Koistinen, A; Leinonen, V; Noe, FM; Hotulainen, P. 2019. Frontiers in molecular neuroscience. 12: 276 A1 Journal article (refereed), original research -
Normaalipaineisen hydrokefaluksen kliininen kuva, diagnostiset tutkimukset ja hoito
Leinonen, Ville; Junkkari, Antti; Rauramaa, Tuomas; Jääskeläinen, Juha E; Vanninen, Ritva; Savolainen, Sakari; Hiltunen, Mikko; Remes, Anne M; Koivisto, Anne M. 2019. Duodecim. 135: 265-273 A2 Review article, Literature review, Systematic review -
Predicting Development of Alzheimer's Disease in Patients with Shunted Idiopathic Normal Pressure Hydrocephalus
Luikku, AJ; Hall, A; Nerg, O; Koivisto, AM; Hiltunen, M; Helisalmi, S; Herukka, SK; Junkkari, A; Sutela, A; Kojoukhova, M; Korhonen, V; Mattila, J; Lötjönen, J; Rummukainen, J; Alafuzoff, I; Jääskeläinen, JE; Remes, AM; Solomon, A; Kivipelto, M; Soininen, H; et al. [Incl. Rauramaa, T; Leinonen, V]. 2019. Journal of Alzheimer's disease. 71: 1233-1243 A1 Journal article (refereed), original research -
Prevalence of C9ORF72 Expansion in a Large Series of Patients with Idiopathic Normal-Pressure Hydrocephalus
Korhonen, VE; Remes, AM; Helisalmi, S; Rauramaa, T; Sutela, A; Vanninen, R; Suhonen, NM; Haapasalo, A; Hiltunen, M; Jääskeläinen, JE; Soininen, H; Koivisto, AM; Leinonen, V. 2019. Dementia and geriatric cognitive disorders. 47: 91-103 A1 Journal article (refereed), original research -
Psychiatric disorders are a common prognostic marker for worse outcome in patients with idiopathic intracranial hypertension
Puustinen, Tero; Tervonen, Joona; Avellan, Cecilia; Jyrkkänen, Henna-Kaisa; Paterno, Jussi J; Hartikainen, Päivi; Vanhanen, Ulla; Leinonen, Ville; Lehto, Soili M; Elomaa, Antti-Pekka; Huttunen, Terhi J. 2019. Clinical neurology and neurosurgery. 186: 105527 A1 Journal article (refereed), original research -
Surgery for degenerative cervical spine disease in Finland, 1999-2015
Kotkansalo, A; Leinonen, V; Korajoki, M; Salmenkivi, J; Korhonen, K; Malmivaara, A. 2019. Acta neurochirurgica. 161: 2147-2159 A1 Journal article (refereed), original research -
Surgical techniques for degenerative cervical spine in Finland from 1999 to 2015
Kotkansalo, A; Malmivaara, A; Korajoki, M; Korhonen, K; Leinonen, V. 2019. Acta neurochirurgica. 161: 2161-2173 A1 Journal article (refereed), original research -
The Kuopio idiopathic normal pressure hydrocephalus protocol: initial outcome of 175 patients
Junkkari, A; Luikku, A J; Danner, N; Jyrkkänen, H K; Rauramaa, T; Korhonen, V E; Koivisto, A M; Nerg, O; Kojoukhova, M; Huttunen, T J; Jääskeläinen, J E; Leinonen, V. 2019. Fluids and barriers of the cns. 16: 21 A1 Journal article (refereed), original research -
[11C]PIB PET Is Associated with the Brain Biopsy Amyloid-ß Load in Subjects Examined for Normal Pressure Hydrocephalus
Rinne, JO; Suotunen, T; Rummukainen, J; Herukka, SK; Nerg, O; Koivisto, AM; Rauramaa, T; Någren, K; Hiltunen, M; Alafuzoff, I; Rinne, J; Jääskeläinen, JE; Soininen, H; Leinonen, V. 2019. Journal of Alzheimer's disease. 67: 1343-1351 A1 Journal article (refereed), original research -
Aikuisten hydrokefalus ja sunttikomplikaatiot
Jääskeläinen, Juha E; Leinonen, Ville. Teoksessa: Jousimaa, Jukkapekka; Alenius, Heidi; Atula, Sari; Berghem, Nora; Kattainen, Anna; Kunnamo, Ilkka; Pelttari, Hanna; Teikar, Martti(toim.) , 2018. Lääkärin käsikirja [online]. s. -. Kustannus Oy Duodecim D2 Article in a professional book (incl. an introduction by the editor) -
Alterations in mitochondria-endoplasmic reticulum connectivity in human brain biopsies from idiopathic normal pressure hydrocephalus patients
Leal, NS; Dentoni, G; Schreiner, B; Kämäräinen, OP; Partanen, N; Herukka, SK; Koivisto, AM; Hiltunen, M; Rauramaa, T; Leinonen, V; Ankarcrona, M. 2018. Acta neuropathologica communications. 6: 102 A1 Journal article (refereed), original research -
Copy number loss in SFMBT1 is common among Finnish and Norwegian patients with iNPH
Korhonen, VE; Helisalmi, S; Jokinen, A; Jokinen, I; Lehtola, JM; Oinas, M; Lönnrot, K; Avellan, C; Kotkansalo, A; Frantzen, J; Rinne, J; Ronkainen, A; Kauppinen, M; Junkkari, A; Hiltunen, M; Soininen, H; Kurki, M; Jääskeläinen, JE; Koivisto, AM; Sato, H; et al. 2018. Neurology : Genetics. 4: e291 A1 Journal article (refereed), original research -
Ensihoidosta neurotehohoitoon
Leinonen, Ville; Kurola, Jouni; Lång, Maarit; Niemelä, Mika; Jääskeläinen, Juha E. Teoksessa: Leppäniemi, Ari; Kuokkanen, Hannu; Salminen, Pauliina(toim.) , 2018. Kirurgia. s. 882-885. Duodecim D2 Article in a professional book (incl. an introduction by the editor) -
Incidence, comorbidities, and mortality in idiopathic normal pressure hydrocephalus
Pyykkö, OT; Nerg, O; Niskasaari, HM; Niskasaari, T; Koivisto, AM; Hiltunen, M; Pihlajamäki, J; Rauramaa, T; Kojoukhova, M; Alafuzoff, I; Soininen, H; Jääskeläinen, JE; Leinonen, V. 2018. World neurosurgery. 112: e624-e631 A1 Journal article (refereed), original research -
Interrelationship between the Levels of C9orf72 and Amyloid-ß Protein Precursor and Amyloid-ß in Human Cells and Brain Samples
Leskelä, S; Takalo, M; Marttinen, M; Huber, N; Paananen, J; Mitra, V; Rauramaa, T; Mäkinen, P; Leinonen, V; Soininen, H; Pike, I; Remes, AM; Hiltunen, M; Haapasalo, A. 2018. Journal of Alzheimer's disease. 62: 269-278 A1 Journal article (refereed), original research -
Keskushermoston neurokirurgisesti hoidettavat infektiot
Leinonen, Ville; Jääskeläinen, Juha E. Teoksessa: Leppäniemi, Ari; Kuokkanen, Hannu; Salminen, Pauliina(toim.) , 2018. Kirurgia. s. 954-955. Duodecim D2 Article in a professional book (incl. an introduction by the editor) -
Keskushermoston toiminta ja häiriötilat
Kivipelto, Leena; Leinonen, Ville; Jääskeläinen, Juha E. Teoksessa: Leppäniemi, Ari; Kuokkanen, Hannu; Salminen, Pauliina(toim.) , 2018. Kirurgia. s. 876-879. Duodecim D2 Article in a professional book (incl. an introduction by the editor) -
Likvorikierron häiriöt
Leinonen, Ville; Jääskeläinen, Juha E. Teoksessa: Leppäniemi, Ari; Kuokkanen, Hannu; Salminen, Pauliina(toim.) , 2018. Kirurgia. s. 955-959. Duodecim D2 Article in a professional book (incl. an introduction by the editor) -
Long-Term Outcome of Spinal Cord Stimulation in Failed Back Surgery Syndrome: 20 Years of Experience With 224 Consecutive Patients
Nissen, Mette; Ikäheimo, Tiina-Mari; Huttunen, Jukka; Leinonen, Ville; von Und Zu Fraunberg, Mikael. 2018. Neurosurgery. 2019; 84: 1011-1018 A1 Journal article (refereed), original research -
Molecular Mechanisms of Synaptotoxicity and Neuroinflammation in Alzheimer's Disease
Marttinen, Mikael; Takalo, Mari; Natunen, Teemu; Wittrahm, Rebekka; Gabbouj, Sami; Kemppainen, Susanna; Leinonen, Ville; Tanila, Heikki; Haapasalo, Annakaisa; Hiltunen, Mikko. 2018. Frontiers in neurology. 12: 963 A2 Review article, Literature review, Systematic review -
Neurokirurgia ja neurotautien yksilöllistetty hoito Suomessa
Niemelä, Mika; Leinonen, Ville; Koivisto, Timo; Kumpulainen, Timo; Öhman, Juha; Rinne, Jaakko; Jääskeläinen, Juha E. Teoksessa: Leppäniemi, Ari; Kuokkanen, Hannu; Salminen, Pauliina(toim.) , 2018. Kirurgia. s. 874-875. Duodecim D2 Article in a professional book (incl. an introduction by the editor) -
Neurokirurgisesti hoidettavien tautien oireet ja kuvantaminen
Leinonen, Ville; Jääskeläinen, Juha E. Teoksessa: Leppäniemi, Ari; Kuokkanen, Hannu; Salminen, Pauliina(toim.) , 2018. Kirurgia. s. 880-882. Duodecim D2 Article in a professional book (incl. an introduction by the editor) -
Prevalence of Schizophrenia in Idiopathic Normal Pressure Hydrocephalus
Vanhala, V; Junkkari, A; Korhonen, VE; Kurki, MI; Hiltunen, M; Rauramaa, T;, Nerg, O;, Koivisto, AM; Remes, AM; Perälä, J; Suvisaari, J; Lehto, S; Viinamäki, H; Soininen, H; Jääskeläinen, JE; Leinonen, V. 2018. Neurosurgery. 2019; 84: 883-889 A1 Journal article (refereed), original research -
Spinaalikanavan sairaudet
Leinonen, Ville; Jääskeläinen, Juha E. Teoksessa: Leppäniemi, Ari; Kuokkanen, Hannu; Salminen, Pauliina(toim.) , 2018. Kirurgia. s. 938-951. Duodecim D2 Article in a professional book (incl. an introduction by the editor) -
Sushi repeat-containing protein X-Linked 2 - a novel phylogenetically conserved hypothalamo-pituitary protein
Anwer, M; Bolkvadze, T; Ndode-Ekane, XE; Puhakka, N; Rauramaa, T; Leinonen, V; van Vliet, EA; Swaab, DF; Haapasalo, A; Leskelä, S; Bister, N; Malm, T; Carlson, S; Aronica, E; Pitkänen, A. 2018. Journal of comparative neurology. 526: 1806-1819 A1 Journal article (refereed), original research -
Value stream map assessment of the extended day: 23h surgery model
Ruohoaho, Ulla-Maija; Kokki, Merja; Hirvonen, Jouni; Joukainen, Sarianna; Aaltomaa, Sirpa; von und zu Fraunberg, Mikael; Leinonen, Ville; Reijula, Jori. 2018. Intelligent buildings international. [Epub 21 MAR 2018]: - A1 Journal article (refereed), original research -
Alzheimer's Disease-Related Polymorphisms in Shunt-Responsive Idiopathic Normal Pressure Hydrocephalus
Huovinen J, Helisalmi S, Paananen J, Laiterä T, Kojoukhova M, Sutela A, Vanninen R, Laitinen M, Rauramaa T, Koivisto AM, Remes AM, Soininen H, Kurki M, Haapasalo A, Jääskeläinen JE, Hiltunen M, Leinonen V. 2017. Journal of Alzheimer's disease. 60: 1077-1085 A1 Journal article (refereed), original research -
Cerebrospinal fluid circulation and hydrocephalus
Leinonen V, Vanninen R, Rauramaa T. Teoksessa: Kovacs Gabor G, Alafuzoff Irina(toim.) , 2017. Handbook of Clinical Neurology. Neuropathology. s. 39-50. Elsevier A3 Book section, Chapters in research books -
Frontotemporal dementia as a comorbidity to idiopathic normal pressure hydrocephalus (iNPH): a short review of literature and an unusual case
Korhonen VE, Solje E, Suhonen NM, Rauramaa T, Vanninen R, Remes AM, Leinonen V. 2017. Fluids and barriers of the cns. 14: 10 A2 Review article, Literature review, Systematic review -
Immunohistochemical Characterization and Sensitivity to Human Adenovirus Serotypes 3, 5, and 11p of New Cell Lines Derived from Human Diffuse Grade II to IV Gliomas
Niittykoski Minna, von und zu Fraunberg Mikael, Martikainen Miika, Rauramaa, Immonen Arto, Koponen Susanna, Leinonen Ville, Vähä-Koskela Markus, Zhang Qiwei, Kühnel Florian, Mei Ya-Fang, Ylä-Herttuala Seppo, Jääskeläinen Juha E, Hinkkanen Ari. 2017. Translational oncology. 10: 772-779 A1 Journal article (refereed), original research -
Niskakipu (aikuiset) : Käypä hoito -suositus (Päivitystiivistelmä)
Karppinen Jaro, Laimi Katri, Leinonen Ville, Malmivaara Antti, Niinimäki Jaakko, Airaksinen Olavi, Arokoski Jari, Auvinen Juha, Jääskeläinen Juhani, Martimo Kari-Pekka, Salo Petri, Soinne Lauri. 2017. Duodecim. 133: 699-700 D1 Article in a trade journal -
Raised intracranial pressure and brain edema
Leinonen V, Vanninen R, Rauramaa T. Teoksessa: Kovacs Gabor G, Alafuzoff Irina(toim.) , 2017. Handbook of Clinical Neurology. Neuropathology. s. 25-37. Elsevier A3 Book section, Chapters in research books -
Rate and Risk Factors for Shunt Revision in Pediatric Patients with Hydrocephalus- A Population-Based Study
Tervonen Joona, Leinonen Ville, Jääskeläinen Juha E, Koponen Susanna, Huttunen Terhi J. 2017. World neurosurgery. 101: 615-622 A1 Journal article (refereed), original research -
Why does the health-related quality of life in idiopathic normal pressure hydrocephalus fail to improve despite the favorable clinical outcome?
Junkkari Antti, Roine Risto P, Luikku Antti, Rauramaa Tuomas, Sintonen Harri, Nerg Ossi, Koivisto Anne M, Häyrinen Antti, Viinamäki Heimo, Soininen Hilkka, Jääskeläinen Juha E, Leinonen Ville. 2017. World neurosurgery. 108: 356-366 A1 Journal article (refereed), original research -
Aneurysmal Subarachnoid Hemorrhage Patients' Risk Assessment for Shunting (aSAH-PARAS): An International Collaborative Study and Initiation of a Consortium
Adams H, Ban VS, Leinonen V, Aoun SG, Huttunen J, Saavalainen T, Lindgren A, Frosen J, Fraunberg M, Koivisto TS, Hernesniemi JA, Welch BG, Jääskeläinen J. 2016. Neurosurgery -
Associations of intracranial pressure with brain biopsy, radiological findings, and shunt surgery outcome in patients with suspected idiopathic normal pressure hydrocephalus
Kojoukhova Maria, Vanha Krista-Irina, Timonen Matti, Koivisto Anne M, Nerg Ossi, Rummukainen Jaana, Rauramaa Tuomas, Vanninen Ritva, Jääskeläinen Juha E, Sutela Anna, Leinonen Ville. 2016. Acta neurochirurgica. 2017; 159: 51-61 A1 Journal article (refereed), original research -
Effects of Alzheimer's Disease-Associated Risk Loci on Amyloid-ß Accumulation in the Brain of Idiopathic Normal Pressure Hydrocephalus Patients
Laiterä Tiina, Paananen Jussi, Helisalmi Seppo, Sarajärvi Timo, Huovinen Joel, Laitinen Marjo, Rauramaa Tuomas, Alafuzoff Irina, Remes Anne M, Soininen Hilkka, Haapasalo Annakaisa, Jääskeläinen Juha E, Leinonen Ville, Hiltunen Mikko. 2016. Journal of Alzheimer's disease. 2017; 55: 995-1003 A1 Journal article (refereed), original research -
Familial idiopathic normal pressure hydrocephalus
Huovinen J, Kastinen S, Komulainen S, Oinas M, Avellan C, Frantzen J, Rinne J, Ronkainen A, Kauppinen M, Lönnrot K, Perola M, Pyykkö OT, Koivisto AM, Remes AM, Soininen H, Hiltunen M, Helisalmi S, Kurki M, Jääskeläinen JE, Leinonen V. 2016. Journal of the neurological sciences. 368: 11-18 A1 Journal article (refereed), original research -
Health-related quality-of-life outcome in patients with idiopathic normal-pressure hydrocephalus - a 1-year follow-up study
Junkkari A, Häyrinen A, Rauramaa T, Sintonen H, Nerg O, Koivisto AM, Roine RP, Viinamäki H, Soininen H, Luikku A, Jääskeläinen JE, Leinonen V. 2016. European journal of neurology. 24: 58-66 A1 Journal article (refereed), original research -
High Risk of Dementia in Ventricular Enlargement with Normal Pressure Hydrocephalus Related Symptoms1
Koivisto Anne M, Kurki Mitja, Alafuzoff Irina, Sutela Anna, Rummukainen Jaana, Savolainen Sakari, Vanninen Ritva, Jääskeläinen Juha E, Soininen Hilkka, Leinonen Ville. 2016. Journal of Alzheimer's disease. 52: 497-507 A1 Journal article (refereed), original research -
Hätäkraniotomiat Pohjois-Karjalan keskussairaalassa vuosina 2006 - 2014
Aro Ellinoora, Jääskeläinen Juha E, Reinikainen Matti, Leinonen Ville, Hakala Tapio. 2016. Duodecim. 132: 858-65 A1 Journal article (refereed), original research -
Implantable RF-coil with multiple electrodes for long-term EEG-fMRI monitoring in rodents
Pirttimäki T, Salo RA, Shatillo A, Kettunen MI, Paasonen J, Sierra A, Jokivarsi K, Leinonen V, Andrade P, Quittek S, Pitkänen A, Gröhn O. 2016. Journal of neuroscience methods. 274: 154-163 A1 Journal article (refereed), original research -
Multimodal analysis to predict shunt surgery outcome of 284 patients with suspected idiopathic normal pressure hydrocephalus
Luikku Antti J, Hall Anette, Nerg Ossi, Koivisto Anne M, Hiltunen Mikko, Helisalmi Seppo, Herukka Sanna-Kaisa, Sutela Anna, Kojoukhova Maria, Mattila Jussi, Lötjönen Jyrki, Rummukainen Jaana, Alafuzoff Irina, Jääskeläinen Juha E, Remes Anne M, Soininen Hilkka, Leinonen Ville. 2016. Acta neurochirurgica. 158: 2311-2319 A1 Journal article (refereed), original research -
Risk of shunting after aneurysmal subarachnoid hemorrhage: a collaborative study and initiation of a consortium
Adams H, Ban VS, Leinonen V, Aoun SG, Huttunen J, Saavalainen T, Lindgren A, Frosen J, Fraunberg M, Koivisto T, Hernesniemi J, Welch BG, Jaaskelainen JE, Huttunen TJ. 2016. Stroke. 47: 2488-96 A1 Journal article (refereed), original research -
SEPT8 modulates ß-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1
Kurkinen Kaisa MA, Marttinen Mikael, Turner Laura, Natunen Teemu, Mäkinen Petra, Haapalinna Fanni, Sarajärvi Timo, Gabbouj Sami, Kurki Mitja, Paananen Jussi, Koivisto Anne M, Rauramaa Tuomas, Leinonen Ville, Tanila Hanila, Soininen Hilkka, Lucas Fiona R, Haapasalo Annakaisa, Hiltunen Mikko. 2016. Journal of cell science. 129: 2224-2238 A1 Journal article (refereed), original research -
Selling vs. non-selling neuro-oncology research cohorts and manuscripts in the eyes of a grumpy reviewer after 2,000 reviews
Leinonen Ville, Jääskeläinen Juha E. 2016. Acta neurochirurgica. 2017; 159: 3-6 A1 Journal article (refereed), original research -
Sub-classification based specific movement control exercises are superior to general exercise in sub-acute low back pain when both are combined with manual therapy: A randomized controlled trial
Lehtola Vesa, Luomajoki Hannu, Leinonen Ville, Gibbons Sean, Airaksinen Olavi. 2016. Bmc musculoskeletal disorders. 17: 135 A1 Journal article (refereed), original research -
Amyloid-ß and Tau Dynamics in Human Brain Interstitial Fluid in Patients with Suspected Normal Pressure Hydrocephalus
Herukka Sanna-Kaisa, Rummukainen Jaana, Ihalainen Jouni, von und zu Fraunberg Mikael, Koivisto Anne M, Nerg Ossi, Puli Lakshman K, Seppälä Toni T, Zetterberg Henrik, Pyykkö Okko T, Helisalmi Seppo, Tanila Heikki, Alafuzoff Irina, Hiltunen Mikko, Rinne Jaakko, Soininen Hilkka, Jääskeläinen Juha E, Leinonen Ville. 2015. Journal of Alzheimer's disease. 46: 261-269 A1 Journal article (refereed), original research -
Analysis of disruptive events and precarious situations caused by interaction with neurosurgical microscope
Eivazi Shahram, Afkari Hoorieh, Bednarik Roman, Leinonen Ville, Tukiainen Markku, Jääskeläinen Juha E. 2015. Acta neurochirurgica. 157: 1147-1154 A1 Journal article (refereed), original research -
Chasing the effects of pre-analytical confounders - a multicenter study on CSF-AD biomarkers
Leitão Maria João, Baldeiras Inês, Herukka Sanna-Kaisa, Pikkarainen Maria, Leinonen Ville, Simonsen Anja Hviid, Perret-Liaudet Armand, Fourier Anthony, Quadrio Isabelle, Veiga Pedro Mota, de Oliveira Catarina Resende. 2015. Frontiers in neurology. 6: 153 A1 Journal article (refereed), original research -
Effects of Alzheimer's Disease-Associated Risk Loci on Cerebrospinal Fluid Biomarkers and Disease Progression: A Polygenic Risk Score Approach
Martiskainen Henna, Helisalmi Seppo, Viswanathan Jayashree, Kurki Mitja, Hall Anette, Herukka Sanna-Kaisa, Sarajärvi Timo, Natunen Teemu, Kurkinen Kaisa M.A., Huovinen Jaakko, Mäkinen Petra, Laitinen Marjo, Koivisto Anne M., Mattila Kari M., Lehtimäki Terho, Remes Anne M., Leinonen Ville, Haapasalo Annakaisa, Soininen Hilkka, Hiltunen Mikko. 2015. Journal of Alzheimer's disease. 43: 565-573 A1 Journal article (refereed), original research -
Embedding an Eye Tracker into a Surgical Microscope: Requirements, Design, and Implementation
Eivazi Shahram, Bednarik R, Leinonen V, von und zu Fraunberg M, Jääskeläinen JE. 2015. IEEE sensors journal. 2016; 16: 2070-2078 A1 Journal article (refereed), original research -
Feasibility of radiological markers in idiopathic normal pressure hydrocephalus
Kojoukhova Maria, Koivisto Anne M, Korhonen Riiika, Remes Anne M, Vanninen Ritva, Soininen Hilkka, Jääskeläinen Juha E, Sutela Anna, Leinonen Ville. 2015. Acta neurochirurgica. 157: 1709-1719 A1 Journal article (refereed), original research -
Genetic Variation in delta-Opioid Receptor Associates with Increased ß- and gamma-Secretase Activity in the Late Stages of Alzheimer's Disease
Sarajärvi Timo, Marttinen Mikael, Natunen Teemu, Kauppinen Tarja, Mäkinen Petra, Helisalmi Seppo, Laitinen Marjo, Rauramaa Tuomas, Leinonen Ville, Petäjä-Repo Ulla, Soininen Hilkka, Haapasalo Annakaisa, Hiltunen Mikko. 2015. Journal of Alzheimer's disease. 48: 507-516 A1 Journal article (refereed), original research -
Health-related quality of life in patients with idiopathic normal pressure hydrocephalus
Junkkari A, Sintonen H, Nerg O, Koivisto AM, Roine RP, Viinamäki H, Soininen H, Jääskeläinen JE, Leinonen V. 2015. European journal of neurology. published online 24 JUN 2015: 9 p A1 Journal article (refereed), original research -
Normaalipaineinen hydrokefalia
Leinonen Ville, Koivisto Anne. Teoksessa: Timo Erkinjuntti, Anne Remes, Juha Rinne, Hilkka Soininen(toim.) , 2015. Muistisairaudet. s. 187-193. Kustannus Oy Duodecim A3 Book section, Chapters in research books -
Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models
Natunen Teemu, Takalo Mari, Kemppainen Ssusanna, Leskelä Stina, Marttinen Mikael, Kurkinen Kaisa MA, Pursiheimo Juha-Pekka, Sarajärvi Timo, Viswanathan Jayashree, Gabbouj Sami, Solje Eino, Tahvanainen Eveliina, Pirttimäki Tiina, Kurki Mitja, Paananen Jussi, Rauramaa Tuomas, Miettinen Pasi, Mäkinen Petra, Leinonen Ville, Soininen Hilkka et al. 2015. Neurobiology of disease. 2016; 85: 187-205 A1 Journal article (refereed), original research -
The Expression of Transthyretin and Amyloid-ß Protein Precursor is Altered in the Brain of Idiopathic Normal Pressure Hydrocephalus Patients
Laiterä Tiina, Kurki Mitja I, Pursiheimo Juha-Pekka, Zetterberg Henrik, Helisalmi Seppo, Rauramaa Tuomas, Alafuzoff Irina, Remes Anne M, Soininen Hilkka, Haapasalo Annakaisa, Jääskeläinen Juha E, Hiltunen Mikko, Leinonen Ville. 2015. Journal of Alzheimer's disease. 48: 959-968 A1 Journal article (refereed), original research -
The effect of decompressive surgery on lumbar paraspinal and biceps brachii muscle function and movement perception in lumbar spinal stenosis: a 2-year follow-up
Kääriäinen Tommi, Taimela Simo, Aalto Timo, Kröger Heikki, Herno Arto, Turunen Veli, Savolainen Sakari, Kankaanpää Markku, Airaksinen Olavi, Leinonen Ville. 2015. European spine journal. 2016; 25: 789-794 A1 Journal article (refereed), original research -
Alaselkäkipu: Käypä hoito -suositus
Pohjolainen T, Leinonen V, Frantzén J, Haanpää M, Jousimaa JP, Karppinen J, Kuukkanen T, Luoma K, Salmenkivi J, Österman H, Malmivaara A. 2014. Duodecim. hoi20001: artikkeli netissä A1 Journal article (refereed), original research -
Association between bone mineral density and lumbar disc degeneration
Salo Sami, Leinonen Ville, Rikkonen Tomi, Vainio Pauli, Marttila Jarkko, Honkanen Risto, Tuppurainen Marjo, Kröger Heikki, Sirola Joonas. 2014. Maturitas. S0378-5122: 00290-4 A1 Journal article (refereed), original research -
Cerebrospinal Fluid Biomarker and Brain Biopsy Findings in Idiopathic Normal Pressure Hydrocephalus
Pyykkö OT, Lumela M, Rummukainen J, Nerg O, Seppälä TT, Herukka SK, Koivisto AM, Alafuzoff I, Puli L, Savolainen S, Soininen H, Jääskeläinen JE, Hiltunen M, Zetterberg H, Leinonen V. 2014. PLoS ONE. 9: 1-10 A1 Journal article (refereed), original research -
Correlation of lateral stenosis in MRI with symptoms, walking capacity and EMG findings in patients with surgically confirmed lateral lumbar spinal canal stenosis
Kuittinen Pekka, Sipola Petri, Aalto Timo Juhani, Määttä Sara, Parviainen Anita, Saari Tapani, Sinikallio Sanna, Savolainen Sakari, Turunen Veli, Kröger Heikki, Airaksinen Olavi, Leinonen Ville. 2014. Bmc musculoskeletal disorders. 15: 247 A1 Journal article (refereed), original research -
Diagnostic effectiveness of quantitative [18F]flutemetamol PET imaging for detection of fibrillar amyloid ß using cortical biopsy histopathology as the standard of truth in subjects with idiopathic normal pressure hydrocephalus
Leinonen V, Rinne JO, Wong DF, Wolk DA, Trojanowski JQ, Sherwin PF, Smith A, Heurling K, Su M, Grachev ID. 2014. Acta neuropathologica communications. 2: 46 A1 Journal article (refereed), original research -
High-fat diet increases tau expression in the brain of T2DM and AD mice independently of peripheral metabolic status
Takalo M, Haapasalo A, Martiskainen H, Kurkinen KM, Koivisto H, Miettinen P, Khandelwal VK, Kemppainen S, Kaminska D, Mäkinen P, Leinonen V, Pihlajamäki J, Soininen H, Laakso M, Tanila H, Hiltunen M. 2014. Journal of nutritional biochemistry. 25: 634-641 A1 Journal article (refereed), original research -
Increased y-Secretase Activity in Idiopathic Normal Pressure Hydrocephalus Patients with b-Amyloid Pathology
Laiterä T, Sarajärvi T, Haapasalo A, Puli L, Kauppinen T, Mäkinen P, Rauramaa T, Tanila H, Jääskeläinen JE, Alafuzoff I, Soininen H, Leinonen V, Hiltunen M. 2014. PLoS ONE. 3: 1-8 A1 Journal article (refereed), original research -
Preoperative MRI Findings Predict Two-Year Postoperative Clinical Outcome in Lumbar Spinal Stenosis
Kuittinen P, Sipola P, Leinonen V, Saari T, Sinikallio S, Savolainen S, Kröger H, Turunen V, Airaksinen O, Aalto T. 2014. PLoS ONE. 9: e106404 A1 Journal article (refereed), original research -
Transcriptomics and mechanistic elucidation of Alzheimer's disease risk genes in the brain and in vitro models
Martiskainen H, Viswanathan J, Nykänen NP, Kurki M, Helisalmi S, Natunen T, Sarajärvi T, Kurkinen KM, Pursiheimo JP, Rauramaa T, Alafuzoff I, Jääskeläinen JE, Leinonen V, Soininen H, Haapasalo A, Huttunen HJ, Hiltunen M. 2014. Neurobiology of aging. 36: 1221.e15-1221.e28 A1 Journal article (refereed), original research -
Visually assessed severity of lumbar spinal canal stenosis is paradoxically associated with leg pain and objective walking ability
Kuittinen Pekka, Sipola Petri, Saari Tapani, Aalto Timo Juhani, Sinikallio Sanna, Savolainen Sakari, Kröger Heikki, Turunen Veli, Leinonen Ville, Airaksinen Olavi. 2014. Bmc musculoskeletal disorders. 15: 348 A1 Journal article (refereed), original research -
Association of Modic changes with health-related quality of life among patients referred to spine surgery
Määttä J, Kautiainen H, Leinonen V, Niinimäki J, Järvenpää S, Koskelainen T, Mäkelä P, Pesälä J, Nyyssönen T, Savolainen S, Airaksinen O, Kyllönen E, Cheung KMC, Karppinen J. 2013. Scandinavian journal of pain. Volume 5: 36-40 A1 Journal article (refereed), original research -
Content validity and responsiveness of a Finnish version of the Patient-Specific Functional Scale
Lehtola V, Kaksonen A, Luomajoki H, Leinonen V, Gibbons S, Airaksinen O. 2013. European journal of physiotherapy. 15: 134-138 A1 Journal article (refereed), original research -
Education of research ethics for clinical investigators with Moodle tool
Halkoaho A, Matveinen M, Leinonen V, Luoto K, Keränen T. 2013. Bmc medical ethics. 14: 53 A1 Journal article (refereed), original research -
Effects of NR1H3 genetic variation on the expression of liver X receptor alfa and the progression of Alzheimer's Disease
Natunen Teemu, Martiskainen Henna, Sarajärvi Timo, Helisalmi Seppo, Pursiheimo Juha-Pekka, Viswanathan Jayashree, Laitinen Marjo, Kauppinen Tarja, Rauramaa Tuomas, Leinonen Ville, Alafuzoff Irina, Haapasalo Annakaisa, Soininen Hilkka, Hiltunen Mikko. 2013. PLoS ONE. 8: e80700 A1 Journal article (refereed), original research -
Influence of comorbidities in idiopathic normal pressure hydrocephalus - research and clinical care. A report of the ISHCSF task force on comorbidities in INPH.
Malm J, Graff-Radford NR, Ishikawa M, Kristensen B, Leinonen V, Mori E, Owler BK, Tullberg M, Williams MA, Relkin NR. 2013. Fluids and barriers of the cns. 10: 22 A1 Journal article (refereed), original research -
Poor cognitive outcome in shunt-responsive idiopathic normal pressure hydrocephalus
Koivisto AM, Alafuzoff I, Savolainen S, Sutela A, Rummukainen J, Kurki M, Jääskeläinen JE, Soininen H, Rinne J, Leinonen V,. 2013. Neurosurgery. 72: 1-8 A1 Journal article (refereed), original research -
Positron emission tomography with [18F]flutemetamol and [11C]PiB for in vivo detection of cerebral cortical amyloid in normal pressure hydrocephalus patients
Leinonen V, Rinne JO, Virtanen KA, Eskola O, Rummukainen J, Huttunen J, von Und Zu Fraunberg M, Nerg O, Koivisto AM, Rinne J, Jääskeläinen JE, Buckley C, Smith A, Jones PA, Sherwin P, Farrar G, McLain R, Kailajärvi M, Heurling K, Grachev ID. 2013. European journal of neurology. 20: 1043-52 A1 Journal article (refereed), original research -
Prospective Flutemetamol Positron Emission Tomography and Histopathology in Normal Pressure Hydrocephalus
Rinne JO, Frantzen J, Leinonen V, Lonnrot K, Laakso A, Virtanen KA, Solin O, Kotkansalo A, Koivisto A, Sajanti J, Karppinen A, Lehto H, Rummukainen J, Buckley C, Smith A, Jones PA, Sherwin P, Farrar G, McLain R, Kailajarvi M, Grachev ID. 2013. Neurodegenerative diseases. epub ahead of print: 9 sivua A1 Journal article (refereed), original research -
APOE4 predicts amyloid-β in cortical brain biopsy but not idiopathic normal pressure hydrocephalus
Pyykkö OT, Helisalmi S, Koivisto AM, Mölsä JA, Rummukainen J, Nerg O, Alafuzoff I, Savolainen S, Soininen H, Jääskeläinen JE, Rinne J, Leinonen V, Hiltunen M. 2012. Journal of neurology neurosurgery and psychiatry. 83: 1119-1124 A1 Journal article (refereed), original research -
Accuracy and reproducibility of a retrospective outcome assessement for lumbar spinal stenosis surgery
Kuittinen P, Aalto T, Heikkilä T, Leinonen V, Savolainen S, Sipola P, Kröger H, Turunen V, Airaksinen O. 2012. Bmc musculoskeletal disorders. 13: 83 A1 Journal article (refereed), original research -
CSF biomarkers for Alzheimer disease correlate with cortical brain biopsy findings
Seppälä TT, Nerg O, Koivisto AM, Rummukainen J, Puli L, Zetterberg H, Pyykkö OT, Helisalmi S, Alafuzoff I, Hiltunen M, Jääskeläinen JE, Rinne J, Soininen H, Leinonen V, Herukka S-K. 2012. Neurology. 78: 1568-1575 A1 Journal article (refereed), original research -
Cortical brain biopsy in long-term prognostication of 468 patients with possible normal pressure hydrocephalus
Leinonen V, Koivisto AM, Alafuzoff I, Pyykkö OT, Rummukainen J, von Und Zu Fraunberg M, Jääskeläinen JE, Soininen H, Rinne J, Savolainen S. 2012. Neurodegenerative diseases. 10: 166-169 A1 Journal article (refereed), original research -
Efficacy of movement control exercises versus general exercises on recurrent sub-acute nonspecific low back pain in a sub-group of patients with movement control dysfunction. Protocol of a randomized controlled trial.
Lehtola V, Luomajoki H, Leinonen V, Gibbons S, Airaksinen O. 2012. Bmc musculoskeletal disorders. 13: 55: 1-9 A1 Journal article (refereed), original research -
Lumbar paraspinal and biceps brachii muscle function and movement perception in lumbar spinal stenosis
Kääriäinen T, Leinonen V, Taimela S, Aalto T, Kröger H, Herno A, Turunen V, Savolainen S, Kankaanpää M, Airaksinen O. 2012. European spine journal. 2012: 6 sivua A1 Journal article (refereed), original research -
Post-mortem findings in 10 patients with presumed normal-pressure hydrocephalus and review of the literature
Leinonen V, Koivisto AM, Savolainen S, Rummukainen J, Sutela A, Vanninen R, Jääskeläinen JE, Soininen H, Alafuzoff I. 2012. Neuropathology and applied neurobiology. 38: 72-86 A1 Journal article (refereed), original research -
Preoperative predictors for good postoperative satisfaction and functional outcome in lumbar spinal stenosis surgery - A prospective observational study with a two-year follow-up
Aalto T, Sinikallio S, Kröger H, Viinamäki H, Herno A, Leinonen V, Turunen V, Savolainen S, Airaksinen O. 2012. Scandinavian journal of surgery. 101: 255-260 A1 Journal article (refereed), original research -
[(18)F]Flutemetamol PET imaging and cortical biopsy histopathology for fibrillar amyloid β detection in living subjects with normal pressure hydrocephalus: pooled analysis of four studies
Rinne JO, Wong DF, Wolk DA, Leinonen V, Arnold SE, Buckley C, Smith A, McLain R, Sherwin PF, Farrar G, Kailajärvi M, Grachev ID. 2012. Acta neuropathologica. 124: 833-845 A1 Journal article (refereed), original research -
Amyloid-beeta and Hyperphospholated Tau in the Prediction of Azheimer's Disease
Rummukainen J, Koivisto AM, Alafuzoff I, Leinonen V. 2011. European neurological review. 6: 84-88 A1 Journal article (refereed), original research -
Cerebrospinal Fluid Biomarkers in Idiopathic Normal Pressure Hydrocephalus
Leinonen V, Menon LG, Carroll RS, Dello Iacono D, Grevet J, Jääskeläinen JE, Black PM. 2011. International journal of alzheimers disease. 2011: 1-6 A1 Journal article (refereed), original research -
Postoperative rehabilitation does not improve functional outcome in lumbar spinal stenosis: a prospective study with 2-year postoperative follow-up
Aalto, Timo J; Leinonen, Ville; Herno, Arto; Alen, Markku; Kröger, Heikki; Turunen, Veli; Savolainen, Sakari; Saari, Tapani; Airaksinen, Olavi. 2011. European spine journal. 20: 1331-1340 A1 Journal article (refereed), original research -
Visual and quantitative assessment of lateral lumbar spinal canal stenosis with magnetic resonance imaging
Sipola P, Leinonen V, Niemeläinen R, Aalto T, Vanninen R, Manninen H, Airaksinen O, Battié MC. 2011. Acta radiologica. 52: 1024-1031 A1 Journal article (refereed), original research -
Muistisairaudet
Erkinjuntti T, Rinne J & Soininen H. 2010. . . WS Bookwell Oy C1 Book -
Assessment of beta-amyloid in a frontal cortical brain biopsy specimen and by positron emission tomography with carbon 11- labeled Pittsburgh compound B
Leinonen V, Alafuzoff I, Aalto S, Suotunen T, Savolainen S, Någren K, Tapiola T, Pirttilä T, Rinne J, Jääskeläinen JE, Soininen H, Rinne J, Pirttilä T, Soininen H. 2008. Archives of neurology. 65: 1304-1309 A1 Journal article (refereed), original research -
The amyloid beta-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae
Hansson Petersen CA, Alikhani N, Behbahani H, Wiehanger B, Pavlov PV, Alafuzoff I, Leinonen V, Ito A, Winbland B, Glaser E, Ankarcrona M. 2008. Proceedings of the National Academy of Sciences of the United States of America. 105: 13145-13150 A1 Journal article (refereed), original research -
Postural control in male patients with hip osteoarthritis
Arokoski JPA, Leinonen V, Arokoski MH, Aalto H, Valtonen H. 2006. Gait and posture. 23: 45-50 A1 Journal article (refereed), original research -
Back and neck extensor loading and back pain provocation in urban bus drivers with and without low back pain
Leinonen V, Kankaanpää M, Vanharanta H, Airaksinen O, Hänninen O. 2005. Pathophysiology. 12: 249-55 A1 Journal article (refereed), original research -
Indigenous healers' explanations of low back pain and its relief
Räsänen V, Leinonen V, Zaproudina N. 2005. Pathophysiology. 12: 313-316 A1 Journal article (refereed), original research -
Wireless on-line electromyography in recording neck muscle function: A pilot study
Airaksinen MK, Kankaanpää M, Aranko O, Leinonen V, Arokoski JPA, Airaksinen O. 2005. Pathophysiology. 12: 303-306 A1 Journal article (refereed), original research -
Lumbar paraspinal muscle function, perception of lumbar postition, and postural control in disc herniation-releted back pain
Leinonen V, Kankaanpää M, Luukonen M, Kansanen M, Hänninen O, Airaksinen O, Taimela S. 2003. Spine. 28: 842-848 A1 Journal article (refereed), original research -
Neuromuscular Control in Lumbar Disorders
Leinonen V. 2003. Kuopio University Publications D. Medical Sciences G5 Doctoral dissertation (article) -
Paraspinal muscle denervation, paradoxically good lumbar endurance, and an abnormal flexion-extension cycle in lumbar spinal stenosis
Leinonen V, Määttä S, Taimela S, Herno A, Kankaanpää M, Partanen J, Hänninen O, Airaksinen O. 2003. Spine. 28: 324-331 A1 Journal article (refereed), original research -
Impaired lumbar movement perception in association with postural stability and motor- and somatosensory-evoked potentials in lumbar spinal stenosis
Leinonen V, Määttä S, Taimela S, Herno A, Kankaanpää M, Partanen J, Kansanen M, Hänninen O, Airaksinen O. 2002. Spine. 27: 975-983 A1 Journal article (refereed), original research -
Disc herniation-related back pain impairs feed-forward control of paraspinal muscles
Leinonen V, Kankaanpää M, Luukkonen M, Hänninen O, Airaksinen O, Taimela S. 2001. Spine. 26: E367-E372 A1 Journal article (refereed), original research -
Back and hip extensor activities during trunk flexion/extension: effects of low back pain and rehabilitation
Leinonen V, Kankaanpää M, Airaksinen O, Hänninen O. 2000. Archives of physical medicine and rehabilitation. 81: 32-37 A1 Journal article (refereed), original research