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Reijo Sironen

Reijo Sironen

Senior Clinical Lecturer

Institute of Clinical Medicine, School of Medicine, Faculty of Health Sciences

[email protected] | +358 40 355 2944

Information Publications

Research groups

Molecular Pathology and Genetics of Cancer 01.01.2022 -

Keywords

histopathology hyaluronan biology immunohistochemical analyses

Publications

71/71 items

High expression of miR-7974 predicts poor prognosis and is associated with autophagy in estrogen receptor-positive breast cancer
Eneh, Stralina; Hartikainen, Jaana M.; Heikkinen, Sami; Sironen, Reijo; Tengström, Maria; Kosma, Veli-Matti; Ahuja, Saket; Mannermaa, Arto, 2025, PLoS ONE, 20, 4, e0322179. A1 Journal article (refereed), original research
Hyaluronan accumulation is associated with reduced hyaluronidase expression in renal cell carcinoma, with CD44, HAS1, and HYAL2 emerging as prognostic markers
Jokelainen, Otto; Rintala, Teemu; Remes, Satu; Pasonen-Seppänen, Sanna; Nykopp, Timo K.; Sironen, Reijo, 2025, The journal of pathology : Clinical research, 11, 4, e70035. A1 Journal article (refereed), original research
Comprehensive analysis of human tissues reveals unique expression and localization patterns of HSF1 and HSF2
Joutsen, Jenny; Pessa, Jenny C; Jokelainen, Otto; Sironen, Reijo; Hartikainen, Jaana M; Sistonen, Lea, 2024, Cell stress and chaperones, 29, 2, 235-271. A1 Journal article (refereed), original research
Differential expression analysis identifies a prognostically significant extracellular matrix–enriched gene signature in hyaluronan-positive clear cell renal cell carcinoma
Jokelainen, Otto; Rintala, Teemu J; Fortino, Vittorio; Pasonen-Seppänen, Sanna; Sironen, Reijo; Nykopp, Timo K, 2024, Scientific reports, 14, 1, 10626. A1 Journal article (refereed), original research
Inflammatory rhabdomyoblastic tumor, pheochromocytoma, and pulmonary hamartoma in a patient with neurofibromatosis type 1: a case report
Jokelainen, Otto; Myllykangas, Heidi; Rajala, Katri; Marttila, Jarkko; Sironen, Reijo, 2024, Diagnostic pathology, 19, 1, 78. A1 Journal article (refereed), original research
2D-shear wave elastography in the evaluation of suspicious superficial inguinal lymph nodes: Reproducibility and region of interest selection
Lahtinen, Olli; Pulkkinen, Mika; Sironen, Reijo; Vanninen, Ritva; Rautiainen, Suvi, 2022, PLoS ONE, 17, 3, e0265802. A1 Journal article (refereed), original research
AAV8-mediated sVEGFR2 and sVEGFR3 gene therapy combined with chemotherapy reduces the growth and microvasculature of human ovarian cancer and prolongs the survival in mice
Kujala, Anni; Valkonen, Elina; Sallinen, Hanna; Tuppurainen, Laura; Laakso, Hanne; Ylä-Herttuala, Elias; Liimatainen, Timo; Kujala, Jouni; Jokelainen, Otto; Sironen, Reijo; Anttila, Maarit; Ylä-Herttuala, Seppo, 2022, Frontiers in medicine, 9, 1018208. A1 Journal article (refereed), original research
Circulating Cell-Free DNA Reflects the Clonal Evolution of Breast Cancer Tumors
Kujala, Jouni; Hartikainen, Jaana M.; Tengström, Maria; Sironen, Reijo; Auvinen, Päivi; Kosma, Veli Matti; Mannermaa, Arto, 2022, Cancers, 14, 5, 1332. A1 Journal article (refereed), original research
Chromatin-directed proteomics-identified network of endogenous androgen receptor in prostate cancer cells
Launonen, Kaisa-Mari; Paakinaho, Ville; Sigismondo, Gianluca; Malinen, Marjo; Sironen, Reijo; Hartikainen, Jaana M; Laakso, Hanna; Visakorpi, Tapio; Krijgsveld, Jeroen; Niskanen, Einari A; Palvimo, Jorma J, 2021, Oncogene, 40, 27, 4567-4579. A1 Journal article (refereed), original research
The role of FoxP3+ regulatory T cells and IDO+ immune and tumor cells in malignant melanoma - an immunohistochemical study
Salmi, Satu; Lin, Anton; Hirschovits-Gerz, Benjamin; Valkonen, Mari; Aaltonen, Niina; Sironen, Reijo; Siiskonen, Hanna; Pasonen-Seppänen, Sanna, 2021, Bmc cancer, 21, 1, 641. A1 Journal article (refereed), original research
Cellular hyaluronan is associated with a poor prognosis in renal cell carcinoma
Jokelainen, Otto; Pasonen-Seppänen, Sanna; Tammi, Markku; Mannermaa, Arto; Aaltomaa, Sirpa; Sironen, Reijo; Nykopp, Timo K, 2020, Urologic oncology: seminars and original investigations, 38, 8, 686.e11-686.e22. A1 Journal article (refereed), original research
High Mutation Burden of Circulating Cell-Free DNA in Early-Stage Breast Cancer Patients Is Associated With a Poor Relapse-Free Survival
Kujala, J; Hartikainen, JM; Tengström, M; Sironen, R; Kosma, VM; Mannermaa, A, 2020, Cancer medicine, 9, 16, 5922-5931. A1 Journal article (refereed), original research
Magnetic resonance imaging characteristics in patients with histopathologically proven fibrous dysplasia - a systematic review
Kinnunen, Anna-Reetta; Sironen, Reijo; Sipola, Petri, 2020, Skeletal radiology, 49, 837-845. A2 Review article, Literature review, Systematic review
CD44s Assembles Hyaluronan Coat on Filopodia and Extracellular Vesicles and Induces Tumorigenicity of MKN74 Gastric Carcinoma Cells
Härkönen, K; Oikari, S; Kyykallio, H; Capra, J; Hakkola, S; Ketola, K; Thanigai Arasu, U; Daaboul, G; Malloy, A; Oliveira, C; Jokelainen, O; Sironen, R; Hartikainen, JM; Rilla, K, 2019, Cells, 8, 3, 276. A1 Journal article (refereed), original research
The number and localization of CD68+ and CD163+ macrophages in different stages of cutaneous melanoma
Salmi, Satu; Siiskonen, Hanna; Sironen, Reijo; Tyynelä-Korhonen, Kristiina; Hirschovits-Gerz, Benjamin; Valkonen, Mari; Auvinen, Päivi; Pasonen-Seppänen, Sanna, 2018, Melanoma research, 29, 3, 237-247. A1 Journal article (refereed), original research
Munuaisbiopsioiden komplikaatiot Kuopion yliopistollisessa sairaalassa vuosina 2013-2016
Kauhanen Petteri S, Suoranta Sanna, Oksala Emma, Karhapää Pauli, Sironen Reijo, Manninen Hannu, Rautiainen Suvi, 2017, Duodecim, 133, 17, 1593-1601. A1 Journal article (refereed), original research
Preoperative sentinel lymph node localization in vulvar cancer: preliminary experience with inguinal intradermal contrast-enhanced ultrasound
Lahtinen O, Eloranta M, Anttila M, Kärkkäinen H, Sironen R, Vanninen R, Rautiainen S, 2017, European radiology, 2018; 28, 5, 2089-2095. A1 Journal article (refereed), original research
Topical cis-urocanic acid prevents ocular surface irritation in both IgE -independent and -mediated rat model
Jauhonen HM, Laihia J, Oksala O, Viiri J, Sironen R, Alajuuma P, Kaarniranta K, Leino L, 2017, Graefes archive for clinical and experimental ophthalmology, 255, 12, 2357-2362. A1 Journal article (refereed), original research
Absence of collagen XVIII in mice causes age-related insufficiency in retinal pigment epithelium proteostasis
Kivinen Niko, Felszeghy Szabolcs, Kinnunen Aino I, Setälä Niko, Aikio Mari, Kinnunen Kati, Sironen Reijo, Pihlajaniemi Taina, Kauppinen Anu, Kaarniranta Kai, 2016, Biogerontology, 17, 4, 749-761. A1 Journal article (refereed), original research
Decreased expression of hyaluronan synthase 1 and 2 associates with poor prognosis in cutaneous melanoma
Poukka M, Bykachev A, Siiskonen H, Tyynelä-Korhonen K, Auvinen P, Pasonen-Seppänen S, Sironen R, 2016, Bmc cancer, 16, 313, 1-11. A1 Journal article (refereed), original research
Incidentally detected enhancing lesions found in breast MRI: analysis of apparent diffusion coefficient and T2 signal intensity significantly improves specificity
Arponen Otso, Masarwah Amro, Sutela Anna, Taina Mikko, Könönen Mervi, Sironen Reijo, Hakumäki Juhana, Vanninen Ritva, Sudah Mazen, 2016, European radiology, 26, 12, 4361-4370. A1 Journal article (refereed), original research
Mesotheliomas show higher hyaluronan positivity around tumor cells than metastatic pulmonary adenocarcinomas
Törrönen Kari, Soini Ylermi, Pääkkö Paavo, Parkkinen Jyrki, Sironen Reijo, Rilla Kirsi, 2016, Histology and histopathology, 31, 10, 1113-1122. A1 Journal article (refereed), original research
Relapsing sepsis episodes of Escherichia coli with CTX-M ESBL or derepressed ampC genes in a patient with chronic autoimmune pancreatitis complicated by IgG4 hypergammaglobulinaemia
Tuuminen T, Österblad M, Hämäläinen S, Sironen R, 2016, New microbes and new infections, 9, 50-53. A1 Journal article (refereed), original research
Contrast-enhanced ultrasound -guided axillary lymph node core biopsy: Diagnostic accuracy in preoperative staging of invasive breast cancer
Rautiainen Suvi, Sudah Mazen, Joukainen Sarianna, Sironen Reijo, Vanninen Ritva, Sutela Anna, 2015, European journal of radiology, 84, 11, 2130-2136. A1 Journal article (refereed), original research
Decreased hyaluronidase 1 expression is associated with early disease recurrence in human endometrial cancer
Nykopp Timo K, Pasonen-Seppänen Sanna, Tammi Markku I, Tammi Raija H, Kosma Veli-Matti, Anttila Maarit, Sironen Reijo, 2015, Gynecologic oncology, 137, 1, 152-159. A1 Journal article (refereed), original research
Diffusion-Weighted Imaging in 3.0 Tesla Breast MRI: Diagnostic Performance and Tumor Characterization Using Small Subregions vs. Whole Tumor Regions of Interest
Arponen Otso, Sudah Mazen, Masarwah Amro, Taina Mikko, Rautiainen Suvi, Könönen Mervi, Sironen Reijo, Kosma Veli-Matti, Sutela Anna, Hakumäki Juhana, Vanninen Ritva, 2015, PLoS ONE, 10, 10, e0138702. A1 Journal article (refereed), original research
Heterogeneity of luminal breast cancer characterised by immunohistochemical expression of basal markers
Sung Hyuna, Garcia-Closas Montserrat, Chang-Claude Jenny, Blows Fiona M, Ali H Raza, Figueroa Jonine, Nevanlinna Heli, Fagerholm Rainer, Heikkilä Päivi, Blomqvist Carl, Giles Graham G, Milne Roger L, Southey Melissa C, McLean Catriona, Mannermaa Arto, Kosma Veli-Matti, Kataja Vesa, Sironen Reijo, Couch Fergus J, Olson Janet E et al, 2015, British journal of cancer, 114 (02 February 2016), 298-304. A1 Journal article (refereed), original research
Low numbers of tryptase+ and chymase+ mast cells associated with reduced survival and advanced tumor stage in melanoma
Siiskonen Hanna, Poukka Mari, Bykachev Andrey, Tyynelä-Korhonen Kristiina, Sironen Reijo, Pasonen-Seppänen Sanna, Harvima Ilkka T, 2015, Melanoma research, [epub ahead of print 27 July 2015]. A1 Journal article (refereed), original research
Preoperative Axillary Staging with 3.0-T Breast MRI: Clinical Value of Diffusion Imaging and Apparent Diffusion Coefficient
Rautiainen Suvi, Könönen Mervi, Sironen Reijo, Masarwah Amro, Sudah Mazen, Hakumäki Juhana, Vanninen Ritva, Sutela Anna, 2015, PLoS ONE, 10, 3, e0122516. A1 Journal article (refereed), original research
SIP1 predicts progression and poor prognosis in pharyngeal squamous cell carcinoma
Jouppila-Mättö Anna, Mannermaa Arto, Sironen Reijo, Kosma Veli-Matti, Soini Ylermi, Pukkila Matti, 2015, Histology and histopathology, 30, 569-579. A1 Journal article (refereed), original research
Hyaluronan synthases (HAS1-3) in stromal and malignant cells correlate with breast cancer grade and predict patient survival
Auvinen Päivi, Rilla Kirsi, Tumelius Ritva, Tammi Markku, Sironen Reijo, Soini Ylermi, Kosma Veli-Matti, Mannermaa Arto, Viikari Jukka, Tammi Raija, 2014, Breast cancer research and treatment, 143, 2, 277-286. A1 Journal article (refereed), original research
Autophagy Activation Clears ELAVL1/HuR-Mediated Accumulation of SQSTM1/p62 during Proteasomal Inhibition in Human Retinal Pigment Epithelial Cells
Viiri J, Amadio M, Marchesi N, Hyttinen JM, Kivinen N, Sironen R, Rilla K, Akhtar S, Provenzani A, D'Agostino VG, Govoni S, Pascale A, Agostini H, Petrovski G, Salminen A, Kaarniranta K, 2013, PLoS ONE, 8, 7, e6963, 16 pages. A1 Journal article (refereed), original research
Axillary Lymph Node Biopsy in Newly Diagnosed Invasive Breast Cancer: Comparative Accuracy of Fine-Needle Aspiration Biopsy versus Core-Needle Biopsy
Rautiainen S, Masarwah A, Sudah M, Sutela A, Pelkonen O, Joukainen S, Sironen R, Kärjä V, Vanninen R, 2013, Radiology, 269, 1, 54-60. A1 Journal article (refereed), original research
Enhanced polyamine catabolism disturbs hematopoietic lineage commitment and leads to a myeloproliferative disease in mice overexpressing spermidine/spermine N 1-acetyltransferase
Pirnes-Karhu S, Mäntymaa P, Sironen R, Mäkinen PI, Wojciechowski S, Juutinen S, Koistinaho J, Hörkkö S, Jantunen E, Alhonen L, Uimari A, 2013, Amino acids, 2013 Jul 9. [Epub ahead of print]. A1 Journal article (refereed), original research
Inverse expression of hyaluronidase 2 and hyaluronan synthases 1-3 is associated with reduced hyaluronan content in malignant cutaneous melanoma
Siiskonen H, Poukka M, Tyynelä-Korhonen K, Sironen R, Pasonen-Seppänen S, 2013, Bmc cancer, 13, 181, e1-12. A1 Journal article (refereed), original research
Matriptase-2 gene (TMPRSS6) variants associate with breast cancer survival, and reduced expression is related to triple-negative breast cancer
Tuhkanen H, Hartikainen JM, Soini Y, Velasco G, Sironen R, Nykopp TK, Kataja V, Eskelinen M, Kosma VM, Mannermaa A., 2013, International journal of cancer, 133, 10, 2334-2340. A1 Journal article (refereed), original research
Systemic overexpression of antizyme 1 in mouse reduces ornithine decarboxylase activity without major changes in tissue polyamine homeostasis
Pietilä M, Dhungana H, Uimari A, Sironen R, Alhonen L, 2013, Transgenic research, [Epub ahead of print]. A1 Journal article (refereed), original research
Increased hyaluronan content and stromal cell CD44 associate with HER2 positivity and poor prognosis in human breast cancer
Auvinen P, Tammi R, Kosma VM, Sironen R, Soini Y, Mannermaa A, Tumelius R, Uljas E, Tammi M, 2012, International journal of cancer, 132, 3, 531-539. A1 Journal article (refereed), original research
Lipopolysaccharide-induced anti-inflammatory acute phase response is enhanced in spermidine/spermine N (1)-acetyltransferase (SSAT) overexpressing mice.
Pirnes-Karhu S, Sironen R, Alhonen L, Uimari A, 2012, Amino acids, 2012 Feb;42(2-3), 473-8. A1 Journal article (refereed), original research
Overexpression of spermidine/spermine N1-acetyltransferase or treatment with N1-N11-diethylnorspermine attenuates the severity of zinc-induced pancreatitis in mouse
Uimari A, Merentie M, Sironen R, Pirnes-Karhu S, Peräniemi S, Alhonen L., 2012, Amino acids, 2012 Feb;42(2-3), 461-71. A1 Journal article (refereed), original research
Associations of Breast Cancer Risk Factors With Tumor Subtypes: A Pooled Analysis From the Breast Cancer Association Consortium Studies
Yang Xiaohong R, Chang-Claude Jenny, Goode Ellen L, Couch Fergus J, Nevanlinna Heli, Milne Roger L, Gaudet Mia, Schmidt Marjanka K, Broeks Annegien, Cox Angela, Fasching Peter A, Hein Rebecca, Spurdle Amanda B, Blows Fiona, Driver Kristy, Flesch-Janys Dieter, Heinz Judith, Sinn Peter, Vrieling Alina, Heikkinen Tuomas et al, 2011, Journal of the national cancer institute, 103, 3, 250-263. A1 Journal article (refereed), original research
Hyaluronan in human malignancies
Sironen RK, Tammi M, Tammi R, Auvinen PK, Anttila M & Kosma VM, 2011, Experimental cell research, 317, 4, 383-391. A1 Journal article (refereed), original research
Transcription factors zeb1, twist and snai1 in breast carcinoma
Soini Ylermi, Tuhkanen Hanna, Sironen Reijo, Virtanen Ismo, Kataja Vesa, Auvinen Päivi, Mannermaa Arto, Kosma Veli-Matti, 2011, Bmc cancer, 11, 11. A1 Journal article (refereed), original research
Transcription of factor snail1 expression and poor survival in pharyngeal squamous cell carcinoma
Jouppila-Mättö A, Tuhkanen H, Soini Y, Pukkila M, Närkiö-Mäkelä M, Sironen R, Virtanen I, Mannermaa A, Kosma V-M, 2011, Histology and histopathology, 26, 443-449. A1 Journal article (refereed), original research
Twist and snai1 expression in pharyngeal squamous cell carcinoma stroma is related to cancer progression
Juoppila-Mättö Anna, Närkiö-Mäkelä Mervi, Soini Ylermi, Pukkila Matti, Sironen Reijo, Tuhkanen Hanna, Mannermaa Arto, Kosma Veli-Matti, 2011, Bmc cancer, 11, 350. A1 Journal article (refereed), original research
Churg-Strauss syndrome manifested by appendicitis, cholecystitis and superficial micronodular liver lesions-an unusual clinicopathological presentation
Sironen RK, Seppä A, Kosma VM, 2010, Journal of clinical pathology, 63, 9, 848-850. A1 Journal article (refereed), original research
Expression of hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in serous ovarian carcinomas: inverse correlation between HYALI and hyaluronan content
Nykopp TK, Rilla K, Sironen R, Tammi MI, Tammi RH, Hämäläinen K, Heikkinen A-M, Komulainen M, Kosma V-M, Anttila M, 2009, Bmc cancer, 9, 143, [9 p.]. A1 Journal article (refereed), original research
Nuclear expression of Snail1 in borderline and malignant epithelial ovarian tumours is associated with tumour progression
Tuhkanen H, Soini Y, Kosma V-M, Anttila M, Sironen R, Hämäläinen K, Kukkonen L, Virtanen I, Mannermaa A, 2009, Bmc cancer, 9, 289. A1 Journal article (refereed), original research
CD44 expression and its relationship with MMP-9, clinicopathological factors and survival in oral squamous cell carcinoma
Kosunen A, Pirinen R, Ropponen K, Pukkila M, Kellokoski J, Virtaniemi J, Sironen R, Juhola M, Kumpulainen E, Johansson R, Nuutinen J, Kosma V-M, 2007, Oral oncology, 43, 51-59. A1 Journal article (refereed), original research
Prognostic significance of extracellular matrix metalloproteinase inducer and matrix metalloproteinase 2 in epithelial ovarian cancer
Sillanpää S, Anttila M, Suhonen K, Hämäläinen K, Turpeenniemi-Hujanen T, Puistola U, Tammi M, Sironen R, Saarikoski S, Kosma VM, 2007, Tumor biology, 28, 5, 280-289. A1 Journal article (refereed), original research
Prognostic significance of matrix metalloproteinase-9 (MMP-9) in epithelial ovarian cancer
Sillanpää S, Anttila M, Voutilainen K, Ropponen K, Turpeenniemi-Hujanen T, Puistola U, Tammi R, Tammi M, Sironen R, Saarikoski S, Kosma V-M, 2007, Gynecologic oncology, 104, 296-303. A1 Journal article (refereed), original research
Prognostic significance of matrix metalloproteinase-7 in epithelial ovarian cancer and its relation to beta-catenin expression
Sillanpää SM, Anttila MA, Voutilainen KA, Ropponen KM, Sironen RK, Saarikoski SV, Kosma V-M, 2006, International journal of cancer, 119, 1792-1799. A1 Journal article (refereed), original research
Geldanamycin activates Hsp70 response and attenuates okadaic acid-induced cytotoxicity in human retinal pigment epithelial cells
Kaarniranta K, Ryhänen T, Sironen RK, Suuronen T, Elo MA, Karjalainen HM, Lammi MJ, Teräsvirta M, Uusitalo H, Salminen A, 2005, MOLECULAR BRAIN RESEARCH, 137, 126-131. A1 Journal article (refereed), original research
High hydrostatic pressure inhibits the biosynthesis of eukaryotic elongation factor-2
Elo MA, Karjalainen HM, Sironen RK, Valmu L, Redpath NT, Browne GJ, Kalkkinen N, Helminen HJ, Lammi MJ, 2005, Journal of cellular biochemistry, 94, 497-507. A1 Journal article (refereed), original research
High hydrostatic pressure induces erk and P13 kinase phosphorylation in human HCS-2/8 chondrosarcoma cells
Kopakkala-Tani M, Elo MA, Sironen RK, Helminen HJ, Lammi MJ, 2004, Cellular and molecular biology, 50, 4, 485-490. A1 Journal article (refereed), original research
Hydrostatic pressure-induced changes in cellular protein syntheisis
Lammi MJ, Elo MA, Sironen RK, Karjalainen HM, Kaarniranta K, Helminen HJ, 2004, Biorheology, 41, 309-313. A1 Journal article (refereed), original research
Reticulon 4 in chondrocytic cells: barosensitivity and intracellular localization
Sironen RK, Karjalainen HM, Törrönen KJ, Elo MA, Hyttinen MM, Helminen HJ, Lammi MJ, 2004, International journal of biochemistry and cell biology, 36, 1521-1531. A1 Journal article (refereed), original research
Gene expression profiles in chondrosarcoma cells subjected to cyclic stretching and hydrostatic pressure. A cDNA array study
Karjalainen HM, Sironen RK, Elo MA, Kaarniranta K, Takigawa M, Helminen HJ, Lammi MJ, 2003, Biorheology, 40, 1-3, 93-100. A1 Journal article (refereed), original research
Specific induction of heat shock protein 90 beta by high hydrostatic pressure
Elo MA, Sironen RK, Karjalainen HM, Kaarniranta K, Helminen HJ, Lammi MJ, 2003, Biorheology, 40, 1-3, 141-146. A1 Journal article (refereed), original research
Stress responses of mammalian cells to high hydrostatic pressure
Kaarniranta K, Elo MA, Sironen RK, Karjalainen HM, Helminen HJ, Lammi MJ, 2003, Biorheology, 40, 1-3, 87-92. A1 Journal article (refereed), original research
Changed lamellipodial extension, adhesion plaques and migration in epidermal keratinocytes containing constitutively expressed sense and antisense hyaluronan synthase 2 (Has2) genes
Rilla K, Lammi MJ, Sironen R, Törrönen K, Luukkonen M, Hascall VC, Midura RJ, Hyttinen M, Pelkonen J, Tammi M, Tammi R, 2002, Journal of cell science, 115, 3633-3643. A1 Journal article (refereed), original research
EGF regulates HAS2 expression, controls epidermal thickness and stimulates keratinocyte migration
Tammi MI, Pienimäki J-P, Rilla K, Fülöp C, Lammi MJ, Sironen R, Midura R, Hascall VC, Luukkonen M, Törrönen K, Lehto T, Tammi R, 2002, Kennedy JF, Phillips GO, Williams PA, Hascall VC, Hyaluronan. Chemical, Biochemical and Biological Aspects., 561-570. A3 Book section, Chapters in research books
High pressure effects on cellular expression profile and mRNA stability. A cDNA array analysis
Sironen RK, Karjalainen HM, Törrönen K, Elo MA, Kaarniranta K, Takigawa M, Helminen HJ, Lammi MJ, 2002, Biorheology, 39, 1,2, 111-117. A1 Journal article (refereed), original research
Hyaluronan synthase 2 (HAS2) regulates migration of epidermal keratinocytes
Rilla K, Lammi M, Sironen R, Hascall VC, Midura R, Tammi M, Tammi R, 2002, Kennedy JF, Phillips GO, Williams PA, Hascall VC, Hyaluronan. Chemical, Biochemical and Biological Aspects, 557-560. A3 Book section, Chapters in research books
cDNA array reveals mechanosensitive genes in chondrocytic cells under hydrostatic pressure
Sironen RK, Karjalainen HM, Elo MA, Kaarniranta K, Törrönen K, Takigawa M, Helminen HJ, Lammi MJ, 2002, Biochimica et biophysica acta: molecular cell research, 1591, 45-54. A1 Journal article (refereed), original research
Epidermal growth factor activates hyaluronan synthase 2 in epidermal keratinocytes and increases pericellular and intracellular hyaluronan
Pienimäki J-P, Rilla K, Csaba F, Sironen RK, Karvinen S, Pasonen S, Lammi MJ, Tammi R, Hascall VC, Tammi MI, 2001, Journal of biological chemistry, 276, 23, 20428-20435. A1 Journal article (refereed), original research
More knee joint osteoarthritis (OA) in mice after inactivation of one allele of type II procollagen gene but less OA after lifelong voluntary wheel running excercise
Lapveteläinen T, Hyttinen M, Lindblom J, Långsjö TK, Sironen R, Li S-W, Arita M, Prockop DJ, Puustjärvi K, Helminen HJ, 2001, Osteoarthritis and cartilage, 9, 2, 152-160. A1 Journal article (refereed), original research
Responses of mammalian cells to mechanical forces
Lammi MJ, Sironen RK, Elo MA, Oksala N, Kaarniranta K, Karjalainen HM, Helminen HJ, 2001, Pandalai SG, Recent Research Developments in Biophysics and Biochemistry, 77-98. A3 Book section, Chapters in research books
Differential regulation of stress proteins by high hydrostatic pressure, heat shock, and unbalanced calcium homeostasis in chondrocytis cells
Elo MA, Sironen RK, Kaarniranta K, Auriola S, Helminen HJ, Lammi MJ, 2000, Journal of cellular biochemistry, 79, 610-619. A1 Journal article (refereed), original research
Transcriptional activation in chondrocytes submitted to hydrostatic pressure
Sironen R, Elo M, Kaarniranta K, Helminen HJ, Lammi MJ, 2000, Biorheology, 37, 85-93. A1 Journal article (refereed), original research
Hsp70 accumulation in chondrocytic cells exposed to high continuous hydrostatic pressure coincides with mRNA stabilization rather than transcriptional activation
Kaarniranta K, Elo M, Sironen R, Lammi MJ, Goldring MB, Eriksson JE, Sistonen L, Helminen HJ, 1998, Proceedings of the National Academy of Sciences of the United States of America, 95, 2319-2324. A1 Journal article (refereed), original research

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Reijo Sironen

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Keywords

High expression of miR-7974 predicts poor prognosis and is associated with autophagy in estrogen receptor-positive breast cancer

Hyaluronan accumulation is associated with reduced hyaluronidase expression in renal cell carcinoma, with CD44, HAS1, and HYAL2 emerging as prognostic markers

Comprehensive analysis of human tissues reveals unique expression and localization patterns of HSF1 and HSF2

Differential expression analysis identifies a prognostically significant extracellular matrix–enriched gene signature in hyaluronan-positive clear cell renal cell carcinoma

Inflammatory rhabdomyoblastic tumor, pheochromocytoma, and pulmonary hamartoma in a patient with neurofibromatosis type 1: a case report

2D-shear wave elastography in the evaluation of suspicious superficial inguinal lymph nodes: Reproducibility and region of interest selection

AAV8-mediated sVEGFR2 and sVEGFR3 gene therapy combined with chemotherapy reduces the growth and microvasculature of human ovarian cancer and prolongs the survival in mice

Circulating Cell-Free DNA Reflects the Clonal Evolution of Breast Cancer Tumors

Chromatin-directed proteomics-identified network of endogenous androgen receptor in prostate cancer cells

The role of FoxP3+ regulatory T cells and IDO+ immune and tumor cells in malignant melanoma - an immunohistochemical study

Cellular hyaluronan is associated with a poor prognosis in renal cell carcinoma

High Mutation Burden of Circulating Cell-Free DNA in Early-Stage Breast Cancer Patients Is Associated With a Poor Relapse-Free Survival

Magnetic resonance imaging characteristics in patients with histopathologically proven fibrous dysplasia - a systematic review

CD44s Assembles Hyaluronan Coat on Filopodia and Extracellular Vesicles and Induces Tumorigenicity of MKN74 Gastric Carcinoma Cells

The number and localization of CD68+ and CD163+ macrophages in different stages of cutaneous melanoma

Munuaisbiopsioiden komplikaatiot Kuopion yliopistollisessa sairaalassa vuosina 2013-2016

Preoperative sentinel lymph node localization in vulvar cancer: preliminary experience with inguinal intradermal contrast-enhanced ultrasound

Topical cis-urocanic acid prevents ocular surface irritation in both IgE -independent and -mediated rat model

Absence of collagen XVIII in mice causes age-related insufficiency in retinal pigment epithelium proteostasis

Decreased expression of hyaluronan synthase 1 and 2 associates with poor prognosis in cutaneous melanoma

Incidentally detected enhancing lesions found in breast MRI: analysis of apparent diffusion coefficient and T2 signal intensity significantly improves specificity

Mesotheliomas show higher hyaluronan positivity around tumor cells than metastatic pulmonary adenocarcinomas

Relapsing sepsis episodes of Escherichia coli with CTX-M ESBL or derepressed ampC genes in a patient with chronic autoimmune pancreatitis complicated by IgG4 hypergammaglobulinaemia

Contrast-enhanced ultrasound -guided axillary lymph node core biopsy: Diagnostic accuracy in preoperative staging of invasive breast cancer

Decreased hyaluronidase 1 expression is associated with early disease recurrence in human endometrial cancer

Diffusion-Weighted Imaging in 3.0 Tesla Breast MRI: Diagnostic Performance and Tumor Characterization Using Small Subregions vs. Whole Tumor Regions of Interest

Heterogeneity of luminal breast cancer characterised by immunohistochemical expression of basal markers

Low numbers of tryptase+ and chymase+ mast cells associated with reduced survival and advanced tumor stage in melanoma

Preoperative Axillary Staging with 3.0-T Breast MRI: Clinical Value of Diffusion Imaging and Apparent Diffusion Coefficient

SIP1 predicts progression and poor prognosis in pharyngeal squamous cell carcinoma

Hyaluronan synthases (HAS1-3) in stromal and malignant cells correlate with breast cancer grade and predict patient survival

Autophagy Activation Clears ELAVL1/HuR-Mediated Accumulation of SQSTM1/p62 during Proteasomal Inhibition in Human Retinal Pigment Epithelial Cells

Axillary Lymph Node Biopsy in Newly Diagnosed Invasive Breast Cancer: Comparative Accuracy of Fine-Needle Aspiration Biopsy versus Core-Needle Biopsy

Enhanced polyamine catabolism disturbs hematopoietic lineage commitment and leads to a myeloproliferative disease in mice overexpressing spermidine/spermine N 1-acetyltransferase

Inverse expression of hyaluronidase 2 and hyaluronan synthases 1-3 is associated with reduced hyaluronan content in malignant cutaneous melanoma

Matriptase-2 gene (TMPRSS6) variants associate with breast cancer survival, and reduced expression is related to triple-negative breast cancer

Systemic overexpression of antizyme 1 in mouse reduces ornithine decarboxylase activity without major changes in tissue polyamine homeostasis

Increased hyaluronan content and stromal cell CD44 associate with HER2 positivity and poor prognosis in human breast cancer

Lipopolysaccharide-induced anti-inflammatory acute phase response is enhanced in spermidine/spermine N (1)-acetyltransferase (SSAT) overexpressing mice.

Overexpression of spermidine/spermine N1-acetyltransferase or treatment with N1-N11-diethylnorspermine attenuates the severity of zinc-induced pancreatitis in mouse

Associations of Breast Cancer Risk Factors With Tumor Subtypes: A Pooled Analysis From the Breast Cancer Association Consortium Studies

Hyaluronan in human malignancies

Transcription factors zeb1, twist and snai1 in breast carcinoma

Transcription of factor snail1 expression and poor survival in pharyngeal squamous cell carcinoma

Twist and snai1 expression in pharyngeal squamous cell carcinoma stroma is related to cancer progression

Churg-Strauss syndrome manifested by appendicitis, cholecystitis and superficial micronodular liver lesions-an unusual clinicopathological presentation

Expression of hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in serous ovarian carcinomas: inverse correlation between HYALI and hyaluronan content

Nuclear expression of Snail1 in borderline and malignant epithelial ovarian tumours is associated with tumour progression

CD44 expression and its relationship with MMP-9, clinicopathological factors and survival in oral squamous cell carcinoma

Prognostic significance of extracellular matrix metalloproteinase inducer and matrix metalloproteinase 2 in epithelial ovarian cancer

Prognostic significance of matrix metalloproteinase-9 (MMP-9) in epithelial ovarian cancer

Prognostic significance of matrix metalloproteinase-7 in epithelial ovarian cancer and its relation to beta-catenin expression

Geldanamycin activates Hsp70 response and attenuates okadaic acid-induced cytotoxicity in human retinal pigment epithelial cells

High hydrostatic pressure inhibits the biosynthesis of eukaryotic elongation factor-2

High hydrostatic pressure induces erk and P13 kinase phosphorylation in human HCS-2/8 chondrosarcoma cells

Hydrostatic pressure-induced changes in cellular protein syntheisis

Reticulon 4 in chondrocytic cells: barosensitivity and intracellular localization

Gene expression profiles in chondrosarcoma cells subjected to cyclic stretching and hydrostatic pressure. A cDNA array study

Specific induction of heat shock protein 90 beta by high hydrostatic pressure

Stress responses of mammalian cells to high hydrostatic pressure

Changed lamellipodial extension, adhesion plaques and migration in epidermal keratinocytes containing constitutively expressed sense and antisense hyaluronan synthase 2 (Has2) genes

EGF regulates HAS2 expression, controls epidermal thickness and stimulates keratinocyte migration

High pressure effects on cellular expression profile and mRNA stability. A cDNA array analysis

Hyaluronan synthase 2 (HAS2) regulates migration of epidermal keratinocytes

cDNA array reveals mechanosensitive genes in chondrocytic cells under hydrostatic pressure

Epidermal growth factor activates hyaluronan synthase 2 in epidermal keratinocytes and increases pericellular and intracellular hyaluronan

More knee joint osteoarthritis (OA) in mice after inactivation of one allele of type II procollagen gene but less OA after lifelong voluntary wheel running excercise

Responses of mammalian cells to mechanical forces

Differential regulation of stress proteins by high hydrostatic pressure, heat shock, and unbalanced calcium homeostasis in chondrocytis cells

Transcriptional activation in chondrocytes submitted to hydrostatic pressure

Hsp70 accumulation in chondrocytic cells exposed to high continuous hydrostatic pressure coincides with mRNA stabilization rather than transcriptional activation