SimuRNA Lab
Leaders
RNA-Ago2-complex where the RNA atoms are shown as spheres and the protein as a ribbon. The colors of the protein display the different domains.
We study RNA-protein interactions using computational methods (docking, molecular dynamics simulations, MM-PBSA…). We are especially interested in argonaute (Ago) proteins which are the main proteins of the RNA induced silencing complex (RISC) and RNA induced activating complex (RITA). Ago2 is the most studied member of this protein family which forms the base of both the protein expression silencing and activating complex with a small RNA molecule (siRNA, saRNA). With the computational methods we aim to decipher how the RNA-Ago2 complexes differ structurally and dynamically so that they have the totally opposite effects on protein production.
News
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Funding from Emil Aaltonen foundationFunding from Emil Aaltonen foundation
PharmD Piia Bartos received 3-year project funding from the Emil Aaltonen foundation to study the differences of protein production inhibiting and…
Projects
Cooperation
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Molecular Modeling and Drug Design Research Group 01.01.2010 - -
Pantsar dynamics 01.10.2022 - -
Transporter-Targeted Drug Delivery 01.09.2012 - -
Molecular Medicine 01.01.1995 -
