Tarja Malm
Professor
A.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences
tarja.malm@uef.fi | +358 40 355 2209
I lead the Neuroinflammation research group. We aim to find regulators of microglial dysfunctions in neurodegenerative diseases.
To find out more of our research, please visit:
https://sites.uef.fi/tarja-malm-group/research-details/
Research groups
-
Biomedical MRI 01.01.1995 - -
In vitro and ex vivo electrophysiology core facil… 01.01.2020 - -
Neuroinflammation research group 01.01.2017 - -
NPH and Early AD 01.01.2010 -
Projects
Publications
148/148 items-
Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer’s disease
Xia, Zengjie; Prescott, Emily E; Urbanek, Agnieszka; Wareing, Hollie E; King, Marianne C; Olerinyova, Anna; Dakin, Helen; Leah, Tom; Barnes, Katy A; Matuszyk, Martyna M; Dimou, Eleni; Hidari, Eric; Zhang, Yu P; Lam, Jeff Y. L; Danial, John SH; Strickland, Michael R; Jiang, Hong; Thornton, Peter; Crowther, Damian C. Ohtonen, Sohvi; Gómez-Budia, Mireia; Bell, Simon M; Ferraiuolo, Laura; Mortiboys, Heather; Higginbottom, Adrian; Wharton, Stephen B; Holtzman, David M; Malm, Tarja; Ranasinghe, Rohan . 2024. Nature communications. 15: . 4695 A1 Journal article (refereed), original research -
Effects of Obesity and Exercise on Hepatic and Pancreatic Lipid Content and Glucose Metabolism: PET Studies in Twins Discordant for BMI
Lietzén, Martin S.; Mari, Andrea; Ojala, Ronja; Hentilä, Jaakko; Koskensalo, Kalle; Lautamäki, Riikka; Löyttyniemi, Eliisa; Parkkola, Riitta; Saunavaara, Virva; Kirjavainen, Anna K.; Rajander, Johan; Malm, Tarja; Lahti, Leo; Rinne, Juha O.; Pietiläinen, Kirsi H.; Iozzo, Patricia; Hannukainen, Jarna C.. 2024. Biomolecules. 14: A1 Journal article (refereed), original research -
Emerging Models to Study Human Microglia In vitro
Jäntti, Henna; Kistemaker, Lois; Buonfiglioli, Alice; De Witte, Lot D.; Malm, Tarja; Hol, Elly M.. Teoksessa: Tremblay, Marie-Ève; Verkhratsky, Alexei(toim.) , 2024. Microglia: Physiology, Pathophysiology and Therapeutic Potential. s. 545-568. Springer A3 Book section, Chapters in research books -
Mechanisms Leading to Increased Insulin-Stimulated Cerebral Glucose Uptake in Obesity and Insulin Resistance: A High-Fat Diet and Exercise Training Intervention PET Study with Rats (CROSRAT)
Jalo, Anna; Helin, Jatta S; Hentilä, Jaakko; Nissinen, Tuuli A; Honkala, Sanna M; Heiskanen, Marja A; Löyttyniemi, Eliisa; Malm, Tarja; Hannukainen, Jarna C. 2024. Journal of functional morphology and kinesiology. 9: A1 Journal article (refereed), original research -
Particulate matter from car exhaust alters function of human iPSC-derived microglia
Jäntti, Henna; Jonk, Steffi; Gómez Budia, Mireia; Ohtonen, Sohvi; Fagerlund, Ilkka; Fazaludeen, Mohammad Feroze; Aakko-Saksa, Päivi; Pebay, Alice; Lehtonen, Šárka; Koistinaho, Jari; Kanninen, Katja M; Jalava, Pasi I; Malm, Tarja; Korhonen, Paula. 2024. Particle and fibre toxicology. 21: . 6 A1 Journal article (refereed), original research -
Regular Exercise Training Induces More Changes on Intestinal Glucose Uptake from Blood and Microbiota Composition in Leaner Compared to Heavier Individuals in Monozygotic Twins Discordant for BMI
Lietzén, Martin S.; Guzzardi, Maria Angela; Ojala, Ronja; Hentilä, Jaakko; Heiskanen, Marja A.; Honkala, Sanna M.; Lautamäki, Riikka; Löyttyniemi, Eliisa; Kirjavainen, Anna K.; Rajander, Johan; Malm, Tarja; Lahti, Leo; Rinne, Juha O.; Pietiläinen, Kirsi H.; Iozzo, Patricia; Hannukainen, Jarna C.. 2024. Nutrients. 16: A1 Journal article (refereed), original research -
StellarPath: Hierarchical-vertical multi-omics classifier synergizes stable markers and interpretable similarity networks for patient profiling
Giudice, Luca; Mohamed, Ahmed; Malm, Tarja. 2024. PLoS computational biology. 20: A1 Journal article (refereed), original research -
Sustained meningeal lymphatic vessel atrophy or expansion does not alter Alzheimer’s disease-related amyloid pathology
Antila, Salli; Chilov, Dmitri; Nurmi, Harri; Li, Zhilin; Näsi, Anni; Gotkiewicz, Maria; Sitnikova, Valeriia; Jäntti, Henna; Acosta, Natalia; Koivisto, Hennariikka; Ray, Jonathan; Keuters, Meike Hedwig; Sultan, Ibrahim; Scoyni, Flavia; Trevisan, Davide; Wojciechowski, Sara; Kaakinen, Mika; Dvořáková, Lenka; Singh, Abhishek; Jukkola, Jari; Korvenlaita, Nea; Eklund, Lauri; Koistinaho, Jari; Karaman, Sinem; Malm, Tarja; Tanila, Heikki; Alitalo, Kari. 2024. Nature cardiovascular research. 3: 474-491 A1 Journal article (refereed), original research -
Traffic-related ultrafine particles impair mitochondrial functions in human olfactory mucosa cells – Implications for Alzheimer's disease
Mussalo, Laura; Lampinen, Riikka; Avesani, Simone; Závodná, Táňa; Krejčík, Zdeněk; Kalapudas, Juho; Penttilä, Elina; Löppönen, Heikki; Koivisto, Anne M; Malm, Tarja; Topinka, Jan; Giugno, Rosalba; Jalava, Pasi; Kanninen, Katja M. 2024. Redox biology. 75: A1 Journal article (refereed), original research -
Uptake of alpha‐synuclein preformed fibrils is suppressed by inflammation and induces an aberrant phenotype in human microglia
Niskanen, Jonna; Peltonen, Sanni; Ohtonen, Sohvi; Fazaludeen, Mohammad Feroze; Luk, Kelvin C; Giudice, Luca; Koistinaho, Jari; Malm, Tarja; Goldsteins, Gundars; Albert, Katrina; Lehtonen, Šárka. 2024. Glia. [First published: 22 October 2024]: 1-16 A1 Journal article (refereed), original research -
ciRS-7 and miR-7 regulate ischemia-induced neuronal death via glutamatergic signaling
Scoyni, Flavia; Sitnikova, Valeriia; Giudice, Luca; Korhonen, Paula; Trevisan, Davide M; Hernandez de Sande, Ana; Gomez-Budia, Mireia; Giniatullina, Raisa; Ugidos, Irene F; Dhungana, Hiramani; Pistono, Cristiana; Korvenlaita, Nea; Välimäki, Nelli-Noora; Kangas, Salla M; Hiltunen, Anniina E; Gribchenko, Emma; Kaikkonen-Määttä, Minna U; Koistinaho, Jari; Ylä-Herttuala, Seppo; Hinttala, Reetta; Venø, Morten T; Su, Junyi; Stoffel, Markus; Schaefer, Anne; Rajewsky, Nikolaus; Kjems, Jørgen; LaPierre, . 2024. Cell reports. 43: A1 Journal article (refereed), original research -
Alzheimer's disease-induced phagocytic microglia express a specific profile of coding and non-coding RNAs
Scoyni, Flavia; Giudice, Luca; Väänänen, Mari Anna; Downes, Nicholas; Korhonen, Paula; Choo, Xin Yi; Välimäki, Nelli Noora; Mäkinen, Petri; Korvenlaita, Nea; Rozemuller, Annemieke J; de Vries, Helga E; Polo, Jose; Turunen, Tiia A; Ylä-Herttuala, Seppo; Hansen, Thomas B; Grubman, Alexandra; Kaikkonen, Minna U; Malm, Tarja. 2023. Alzheimer's & dementia. 2024; 20: 954-974 A1 Journal article (refereed), original research -
Bone marrow metabolism is affected by body weight and response to exercise training varies according to anatomical location
Ojala, Ronja; Hentilä, Jaakko; Lietzén, Martin S; Arponen, Milja; Heiskanen, Marja A; Honkala, Sanna M; Virtanen, Heidi; Koskensalo, Kalle; Lautamäki, Riikka; Löyttyniemi, Eliisa; Parkkola, Riitta; Heinonen, Olli J; Malm, Tarja; Lahti, Leo; Rinne, Juha; Eskola, Olli; Rajander, Johan; Pietiläinen, Kirsi H; Kaprio, Jaakko; Ivaska, Kaisa K.; Hannukainen, Jarna C. 2023. Diabetes obesity and metabolism. 2024; 26: 251-261 A1 Journal article (refereed), original research -
Construction of Fusion Protein for Enhanced Small RNA Loading to Extracellular Vesicles
Es-Haghi, Masoumeh; Neustroeva, Olga; Chowdhury, Iftekhar; Laitinen, Pia; Väänänen, Mari-Anna; Korvenlaita, Nea; Malm, Tarja; Turunen, Mikko P; Turunen, Tiia A. 2023. Genes. 14: A1 Journal article (refereed), original research -
Dynamic release of neuronal extracellular vesicles containing miR‐21a‐5p is induced by hypoxia
Korvenlaita, Nea; Gómez‐Budia, Mireia; Scoyni, Flavia; Pistono, Cristiana; Giudice, Luca; Eamen, Shaila; Loppi, Sanna; de Sande, Ana Hernández; Huremagic, Benjamin; Bouvy‐Liivrand, Maria; Heinäniemi, Merja; Kaikkonen, Minna U.; Cheng, Lesley; Hill, Andrew F.; Kanninen, Katja M.; Jenster, Guido W.; van Royen, Martin E.; Ramiro, Laura; Montaner, Joan; Batkova, Tereza; Mikulik, Robert; Giugno, Rosalba; Jolkkonen, Jukka; Korhonen, Paula; Malm, Tarja. 2023. Journal of extracellular vesicles. 12: A1 Journal article (refereed), original research -
Early Alzheimer's disease pathology in human cortex involves transient cell states
Gazestani, Vahid; Kamath, Tushar; Nadaf, Naeem M; Dougalis, Antonios; Burris, SJ; Rooney, Brendan; Junkkari, Antti; Vanderburg, Charles; Pelkonen, Anssi; Gomez-Budia, Mireia; Välimäki, Nelli Noora; Rauramaa, Tuomas; Therrien, Martine; Koivisto, Anne M; Tegtmeyer, Matthew; Herukka, Sanna Kaisa; Abdulraouf, Abdulraouf; Marsh, Samuel E; Hiltunen, Mikko; Nehme, Ralda; Malm, Tarja; Stevens, Beth; Leinonen, Ville; Macosko, Evan Z. 2023. Cell. 186: 4438-4453.e23 A1 Journal article (refereed), original research -
Emissions from modern engines induce distinct effects in human olfactory mucosa cells, depending on fuel and aftertreatment
Mussalo, Laura; Avesani, Simone; Shahbaz, Muhammad Ali; Zavodna, Tana; Saveleva, Liudmila; Järvinen, Anssi; Lampinen, Riikka; Belaya, Irina; Krejcik, Zdenek; Ivanova, Mariia; Hakkarainen, Henri; Kalapudas, Juho; Penttilä, Elina; Löppönen, Heikki; Koivisto, Anne M; Malm, Tarja; Topinka, Jan; Giugno, Rosalba; Aakko-Saksa, Päivi; Chew, Sweelin; Rönkkö, Topi; Jalava, Pasi; Kanninen, Katja M. 2023. Science of the total environment. 905: A1 Journal article (refereed), original research -
Human iPSC-derived microglia carrying the LRRK2-G2019S mutation show a Parkinson’s disease related transcriptional profile and function
Ohtonen, Sohvi; Giudice, Luca; Jäntti, Henna; Fazaludeen, Mohammad Feroze; Shakirzyanova, Anastasia; Gómez-Budia, Mireia; Välimäki, Nelli-Noora; Niskanen, Jonna; Korvenlaita, Nea; Fagerlund, Ilkka; Koistinaho, Jari; Amiry-Moghaddam, Mahmood; Savchenko, Ekaterina; Roybon, Laurent; Lehtonen, Šárka; Korhonen, Paula; Malm, Tarja. 2023. Scientific reports. 13: . 22118 A1 Journal article (refereed), original research -
Reduced binding of apoE4 to complement factor H promotes amyloid‐β oligomerization and neuroinflammation
Chernyaeva, Larisa; Ratti, Giorgio; Teirilä, Laura; Fudo, Satoshi; Rankka, Uni; Pelkonen, Anssi; Korhonen, Paula; Leskinen, Katarzyna; Keskitalo, Salla; Salokas, Kari; Gkolfinopoulou, Christina; Crompton, Katrina E; Javanainen, Matti; Happonen, Lotta; Varjosalo, Markku; Malm, Tarja; Leinonen, Ville; Chroni, Angeliki; Saavalainen, Päivi; Meri, Seppo; Kajander, Tommi; Wollman, Adam JM; Nissilä, Eija; Haapasalo, Karita. 2023. Embo reports. 24: A1 Journal article (refereed), original research -
Transcriptomic Alterations in the Olfactory Bulb Induced by Exposure to Air Pollution: Identification of Potential Biomarkers and Insights into Olfactory System Function
Saveleva, Liudmila; Sima, Michal; Klema, Jiri; Krejčík, Zdeněk; Vartiainen, Petra; Sitnikova, Valeriia; Belaya, Irina; Malm, Tarja; Jalava, Pasi I; Rössner, Pavel; Kanninen, Katja M. 2023. Environmental toxicology and pharmacology. 104: A1 Journal article (refereed), original research -
Activation of Meningeal Afferents Relevant to Trigeminal Headache Pain after Photothrombotic Stroke Lesion: A Pilot Study in Mice
Krivoshein, Georgii; Bakreen, Abdulhameed; van den Maagdenberg, Arn MJM; Malm, Tarja; Giniatullin, Rashid; Jolkkonen, Jukka. 2022. International journal of molecular sciences. 23: A1 Journal article (refereed), original research -
Air Pollution Exposure Increases ABCB1 and ASCT1 Transporter Levels in Mouse Cortex
Puris, Elena; Saveleva, Liudmila; Górová, Veronika; Vartiainen, Petra; Kortelainen, Miika; Lamberg, Heikki; Sippula, Olli; Malm, Tarja; Jalava, Pasi I; Auriola, Seppo; Fricker, Gert; Kanninen, Katja M. 2022. Environmental toxicology and pharmacology. 96: A1 Journal article (refereed), original research -
Astrocyte Progenitors Derived From Patients With Alzheimer Disease Do Not Impair Stroke Recovery in Mice
Välimäki, Nelli-Noora; Bakreen, Abdulhameed; Häkli, Sara; Dhungana, Hiramani; Keuters, Meike H; Dunlop, Yannick; Koskuvi, Marja; Keksa-Goldsteine, Velta; Oksanen, Minna; Jäntti, Henna; Lehtonen, Šárka; Malm, Tarja; Koistinaho, Jari; Jolkkonen, Jukka. 2022. Stroke. 53: 3192-3201 A1 Journal article (refereed), original research -
Emerging Role of miR-21-5p in Neuron–Glia Dysregulation and Exosome Transfer Using Multiple Models of Alzheimer’s Disease
Garcia, Gonçalo; Pinto, Sara; Ferreira, Sofia; Lopes, Daniela; Serrador, Maria João; Fernandes, Adelaide; Vaz, Ana Rita; Mendonça, Alexandre de; Edenhofer, Frank; Malm, Tarja; Koistinaho, Jari; Brites, Dora. 2022. Cells. 11: A1 Journal article (refereed), original research -
High Soluble Amyloid-β42 Predicts Normal Cognition in Amyloid-Positive Individuals with Alzheimer’s Disease-Causing Mutations
Sturchio, Andrea; Dwivedi, Alok K; Malm, Tarja; Wood, Matthew JA; Cilia, Roberto; Sharma, Jennifer S; Hill, Emily J; Schneider, Lon S; Graff-Radford, Neill R; Mori, Hiroshi; Nübling, Georg; El Andaloussi, Samir; Svenningsson, Per; Ezzat, Kariem; Espay, Alberto J; the Dominantly Inherited Alzheimer Consortia (DIAN). 2022. Journal of Alzheimer's disease. 90: 333-348 A1 Journal article (refereed), original research -
Human PSEN1 Mutant Glia Improve Spatial Learning and Memory in Aged Mice
Jäntti, Henna; Oksanen, Minna; Kettunen, Pinja; Manta, Stella; Mouledous, Lionel; Koivisto, Hennariikka; Ruuth, Johanna; Trontti, Kalevi; Dhungana, Hiramani; Keuters, Meike; Weert, Isabelle; Koskuvi, Marja; Hovatta, Iiris; Linden, Anni-Maija; Rampon, Claire; Malm, Tarja; Tanila, Heikki; Koistinaho, Jari; Rolova, Taisia. 2022. Cells. 11: A1 Journal article (refereed), original research -
Inactivation of mouse transmembrane prolyl 4-hydroxylase increases blood brain barrier permeability and ischemia-induced cerebral neuroinflammation
Byts, Nadiya; Sharma, Subodh; Malm, Tarja; Kaakinen, Mika; Korhonen, Paula; Jaakkonen, Laura; Keuters, Meike; Huuskonen, Mikko; Pietilä, Ilkka; Koistinaho, Jari; Koivunen, Peppi; Myllyharju, Johanna. 2022. Journal of biological chemistry. 298: A1 Journal article (refereed), original research -
Increased Expression and Activity of Brain Cortical cPLA2 Due to Chronic Lipopolysaccharide Administration in Mouse Model of Familial Alzheimer’s Disease
Gynther, Mikko; Estrada, Mariana Leal; Loppi, Sanna; Korhonen, Paula; Kanninen, Katja M.; Malm, Tarja; Koistinaho, Jari; Auriola, Seppo; Fricker, Gert; Puris, Elena. 2022. Pharmaceutics. 14: A1 Journal article (refereed), original research -
Metabolomic, Lipidomic and Proteomic Characterisation of Lipopolysaccharide-induced Inflammation Mouse Model
Puris, Elena; Kouřil, Štěpán; Najdekr, Lukáš; Auriola, Seppo; Loppi, Sanna; Korhonen, Paula; Gómez-Budia, Mireia; Fricker, Gert; Kanninen, Katja M; Malm, Tarja; Friedecký, David; Gynther, Mikko. 2022. Neuroscience. 496: 165-178 A1 Journal article (refereed), original research -
Microglia states and nomenclature: A field at its crossroads
Paolicelli, Rosa C.; Sierra, Amanda; Stevens, Beth; Tremblay, Marie-Eve; Aguzzi, Adriano; Ajami, Bahareh; Amit, Ido; Audinat, Etienne; Bechmann, Ingo; Bennett, Mariko; Bennett, Frederick; Bessis, Alain; Biber, Knut; Bilbo, Staci; Blurton-Jones, Mathew; Boddeke, Erik; Brites, Dora; Brône, Bert; Brown, Guy C.; Butovsky, Oleg; Carson, Monica J.; Castellano, Bernardo; Colonna, Marco; Cowley, Sally A.; Cunningham, Colm; Davalos, Dimitrios; De Jager, Philip L.; de Strooper, Bart; Denes, Adam; Eggen, B. 2022. Neuron. 110: 3458-3483 A2 Review article, Literature review, Systematic review -
Microglial amyloid beta clearance is driven by PIEZO1 channels
Jäntti, Henna; Sitnikova, Valeriia; Ishchenko, Yevheniia; Shakirzyanova, Anastasia; Giudice, Luca; Ugidos, Irene F; Gómez-Budia, Mireia; Korvenlaita, Nea; Ohtonen, Sohvi; Belaya, Irina; Fazaludeen, Feroze; Mikhailov, Nikita; Gotkiewicz, Maria; Ketola, Kirsi; Lehtonen, Šárka; Koistinaho, Jari; Kanninen, Katja M; Hernández, Damian; Pébay, Alice; Giugno, Rosalba; Korhonen, Paula; Giniatullin, Rashid; Malm, Tarja. 2022. Journal of neuroinflammation. 19: . 147 A1 Journal article (refereed), original research -
Neuron-astrocyte transmitophagy is altered in Alzheimer's disease
Lampinen, Riikka; Belaya, Irina; Saveleva, Liudmila; Liddell, Jeffrey R; Rait, Dzhessi; Huuskonen, Mikko T; Giniatullina, Raisa; Sorvari, Annika; Soppela, Liisi; Mikhailov, Nikita; Boccuni, Isabella; Giniatullin, Rashid; Cruz-Haces, Marcela; Konovalova, Julia; Koskuvi, Marja; Domanskyi, Andrii; Hämäläinen, Riikka H; Goldsteins, Gundars; Koistinaho, Jari; Malm, Tarja; Chew, Sweelin; Rilla, Kirsi; White, Anthony R; Marsh-Armstrong, Nicholas; Kanninen, Katja M. 2022. Neurobiology of disease. 170: A1 Journal article (refereed), original research -
Novel Anti-Neuroinflammatory Properties of a Thiosemicarbazone–Pyridylhydrazone Copper(II) Complex
Choo, Xin Yi; McInnes, Lachlan E; Grubman, Alexandra; Wasielewska, Joanna M; Belaya, Irina; Burrows, Emma; Quek, Hazel; Martín, Jorge Cañas; Loppi, Sanna; Sorvari, Annika; Rait, Dzhessi; Powell, Andrew; Duncan, Clare; Liddell, Jeffrey R.; Tanila, Heikki; Polo, Jose M; Malm, Tarja; Kanninen, Katja M.; Donnelly, Paul S; White, Anthony R. 2022. International journal of molecular sciences. 23: A1 Journal article (refereed), original research -
Nuclear microRNA-466c regulates Vegfa expression in response to hypoxia
Laitinen, Pia; Väänänen, Mari-Anna; Kolari, Ida-Liisa; Mäkinen, Petri I.; Kaikkonen, Minna U.; Weinberg, Marc S.; Morris, Kevin V.; Korhonen, Paula; Malm, Tarja; Ylä-Herttuala, Seppo; Roberts, Thomas C.; Turunen, Mikko P.; Turunen, Tiia A.. 2022. PLoS ONE. 17: A1 Journal article (refereed), original research -
Sex Differences in Poststroke Inflammation: a Focus on Microglia Across the Lifespan
Ugidos, Irene F; Pistono, Cristiana; Korhonen, Paula; Gómez-Budia, Mireia; Sitnikova, Valeriia; Klecki, Pamela; Stanová, Iveta; Jolkkonen, Jukka; Malm, Tarja. 2022. Stroke. 53: 1500-1509 A2 Review article, Literature review, Systematic review -
Single-Cell RNA-Seq Analysis of Olfactory Mucosal Cells of Alzheimer’s Disease Patients
Lampinen, Riikka; Fazaludeen, Mohammad Feroze; Avesani, Simone; Örd, Tiit; Penttilä, Elina; Lehtola, Juha-Matti; Saari, Toni; Hannonen, Sanna; Saveleva, Liudmila; Kaartinen, Emma; Fernández Acosta, Francisco; Cruz-Haces, Marcela; Löppönen, Heikki; Mackay-Sim, Alan; Kaikkonen, Minna U; Koivisto, Anne M; Malm, Tarja; White, Anthony R; Giugno, Rosalba; Chew, Sweelin; Kanninen, Katja M. 2022. Cells. 11: A1 Journal article (refereed), original research -
Subacute inhalation of ultrafine particulate matter triggers inflammation without altering amyloid beta load in 5xFAD mice
Saveleva, Liudmila; Vartiainen, Petra; Górová, Veronika; Chew, Sweelin; Belaya, Irina; Konttinen, Henna; Zucchelli, Martina; Korhonen, Paula; Kaartinen, Emma; Kortelainen, Miika; Lamberg, Heikki; Sippula, Olli; Malm, Tarja; Jalava, Pasi I; Kanninen, Katja M. 2022. Neurotoxicology. 89: 55-66 A1 Journal article (refereed), original research -
Systemic inflammation elevates cytosolic prolyl oligopeptidase protein expression but not peptidase activity in the cerebral cortices of familial Alzheimer`s disease modeling mice
Puris, Elena; Jalkanen, Aaro; Auriola, Seppo; Loppi, Sanna; Korhonen, Paula; Kanninen, Katja M.; Malm, Tarja; Koistinaho, Jari; Gynther, Mikko. 2022. Brain disorders. 6: A1 Journal article (refereed), original research -
TUBE Project: Transport-Derived Ultrafines and the Brain Effects
Martikainen, Maria-Viola; Aakko-Saksa, Päivi; van den Broek, Lenie; Cassee, Flemming R; Carare, Roxana O; Chew, Sweelin; Dinnyes, Andras; Giugno, Rosalba; Kanninen, Katja M; Malm, Tarja; Muala, Ala; Nedergaard, Maiken; Oudin, Anna; Oyola, Pedro; Pfeiffer, Tobias V; Rönkkö, Topi; Saarikoski, Sanna; Sandström, Thomas; Schins, Roel PF; Topinka, Jan; Yang, Mo; Zeng, Xiaowen; Westerink, Remco HS; Jalava, Pasi I. 2022. International journal of environmental research and public health. 19: A1 Journal article (refereed), original research -
The State of the Art of Piezo1 Channels in Skeletal Muscle Regeneration
Bernareggi, Annalisa; Bosutti, Alessandra; Massaria, Gabriele; Giniatullin, Rashid; Malm, Tarja; Sciancalepore, Marina; Lorenzon, Paola. 2022. International journal of molecular sciences. 23: A2 Review article, Literature review, Systematic review -
The role of the meningeal lymphatic system in local meningeal inflammation and trigeminal nociception
Mikhailov, Nikita; Virenque, Anaïs; Koroleva, Kseniia; Eme-Scolan, Elisa; Teleman, Matei; Abdollahzadeh, Ali; Giniatullina, Raisa; Gafurov, Oleg; Krivoshein, Georgii; Malm, Tarja; Hämäläinen, Riikka H; Sierra, Alejandra; Tohka, Jussi; Rua, Rejane; Noe, Francesco M; Giniatullin, Rashid. 2022. Scientific reports. 12: . 8804 A1 Journal article (refereed), original research -
"Time window" effect of Yoda1-evoked Piezo1 channel activity during mouse skeletal muscle differentiation
Bosutti, Alessandra; Giniatullin, Arthur; Odnoshivkina, Yulia; Giudice, Luca; Malm, Tarja; Sciancalepore, Marina; Giniatullin, Rashid; D'Andrea, Paola; Lorenzon, Paola; Bernareggi, Annalisa. 2021. Acta physiologica. 233: e13702 A1 Journal article (refereed), original research -
Additive Behavioral Improvement after Combined Cell Therapy and Rehabilitation Despite Long-Term Microglia Presence in Stroke Rats
Bakreen, Abdulhameed; Juntunen, Miia; Dunlop, Yannick; Ugidos, Irene F.; Malm, Tarja; Miettinen, Susanna; Jolkkonen, Jukka. 2021. International journal of molecular sciences. 22: 1512 A1 Journal article (refereed), original research -
Alzheimerin taudin uudet riskigeenit - keskiössä mikrogliasolut
Martiskainen, Henna; Takalo, Mari; Konttinen, Henna; Malm, Tarja; Haapasalo, Annakaisa; Leinonen, Ville; Hiltunen, Mikko. 2021. Duodecim. 137: 1375- 1382 A2 Review article, Literature review, Systematic review -
An arylthiazyne derivative is a potent inhibitor of lipid peroxidation and ferroptosis providing neuroprotection in vitro and in vivo
Keuters, Meike Hedwig; Keksa-Goldsteine, Velta; Dhungana, Hiramani; Huuskonen, Mikko T; Pomeshchik, Yuriy; Savchenko, Ekaterina; Korhonen, Paula K; Singh, Yajuvinder; Wojciechowski, Sara; Lehtonen, ¦árka; Kanninen, Katja M; Malm, Tarja; Sirviö, Jouni; Muona, Anu; Koistinaho, Milla; Goldsteins, Gundars; Koistinaho, Jari. 2021. Scientific reports. 11: 3518 A1 Journal article (refereed), original research -
Extracellular Vesicles from Human Teeth Stem Cells Trigger ATP Release and Promote Migration of Human Microglia through P2X4 Receptor/MFG-E8-Dependent Mechanisms
Jonavice, Ugne; Romenskaja, Diana; Kriauciunaite, Karolina; Jarmalaviciute, Akvile; Pajarskiene, Justina; Ka¨eta, Vytautas; Tunaitis, Virginijus; Malm, Tarja; Giniatulin, Rashid; Pivoriunas, Augustas. 2021. International journal of molecular sciences. 22: 10970 A1 Journal article (refereed), original research -
Functional Characterization of Human Pluripotent Stem Cell-Derived Models of the Brain with Microelectrode Arrays
Pelkonen, Anssi; Pistono, Cristiana; Klecki, Pamela; Gómez-Budia, Mireia; Dougalis, Antonios; Konttinen, Henna; Stanová, Iveta; Fagerlund, Ilkka; Leinonen, Ville; Korhonen, Paula; Malm, Tarja. 2021. Cells. 2022; 11: 106 A2 Review article, Literature review, Systematic review -
Glia-Derived Extracellular Vesicles: Role in Central Nervous System Communication in Health and Disease
Pistono, Cristiana; Bister, Nea; Stanová, Iveta; Malm, Tarja. 2021. Frontiers in cell and developmental biology. 8: 623771 A2 Review article, Literature review, Systematic review -
High cerebrospinal amyloid-β 42 is associated with normal cognition in individuals with brain amyloidosis
Sturchio, Andrea; Dwivedi, Alok K.; Young, Christina B.; Malm, Tarja; Marsili, Luca; Sharma, Jennifer S.; Mahajan, Abhimanyu; Hill, Emily J.; Andaloussi, Samir EL; Poston, Kathleen L.; Manfredsson, Fredric P.; Schneider, Lon S.; Ezzat, Kariem; Espay, Alberto J.. 2021. EClinicalMedicine. 38: 100988 A1 Journal article (refereed), original research -
Metabolomic and lipidomic changes triggered by lipopolysaccharide-induced systemic inflammation in transgenic APdE9 mice
Puris, Elena; Kouril, ¦tepán; Najdekr, Luká¨; Loppi, Sanna; Korhonen, Paula; Kanninen, Katja M.; Malm, Tarja; Koistinaho, Jari; Friedecký, David; Gynther, Mikko. 2021. Scientific reports. 11: 13076 A1 Journal article (refereed), original research -
Microglia Development and Maturation and Its Implications for Induction of Microglia-Like Cells from Human iPSCs
Wurm, Johannes; Konttinen, Henna; Andressen, Christian; Malm, Tarja; Spittau, Björn. 2021. International journal of molecular sciences. 22: 3088 A2 Review article, Literature review, Systematic review -
Microglia-like Cells Promote Neuronal Functions in Cerebral Organoids
Fagerlund, Ilkka; Dougalis, Antonios; Shakirzyanova, Anastasia; Gómez-Budia, Mireia; Pelkonen, Anssi; Konttinen, Henna; Ohtonen, Sohvi; Fazaludeen, Mohammad Feroze; Koskuvi, Marja; Kuusisto, Johanna; Hernández, Damián; Pebay, Alice; Koistinaho, Jari; Rauramaa, Tuomas; Lehtonen, ¦árka; Korhonen, Paula; Malm, Tarja. 2021. Cells. 2022; 11: 124 A1 Journal article (refereed), original research -
Regular Physical Exercise Modulates Iron Homeostasis in the 5xFAD Mouse Model of Alzheimer's Disease
Belaya, Irina; Kucháriková, Nina; Górová, Veronika; Kysenius, Kai; Hare, Dominic J.; Crouch, Peter J.; Malm, Tarja; Atalay, Mustafa; White, Anthony R.; Liddell, Jeffrey R.; Kanninen, Katja M.. 2021. International journal of molecular sciences. 22: 8715 A1 Journal article (refereed), original research -
Systemic cross-talk between brain, gut, and peripheral tissues in glucose homeostasis: effects of exercise training (CROSSYS). Exercise training intervention in monozygotic twins discordant for body weight
Heiskanen, Marja A; Honkala, Sanna M; Hentilä, Jaakko; Ojala, Ronja; Lautamäki, Riikka; Koskensalo, Kalle; Lietzen, Martin S; Saunavaara, Virva; Saunavaara, Jani; Helmio, Mika; Löyttyniemi, Eliisa; Nummenmaa, Lauri; Collado, Maria C; Malm, Tarja; Lahti, Leo; Pietiläinen, Kirsi H; Kaprio, Jaakko; Rinne, Juha O; Hannukainen, Jarna C. 2021. BMC sports science, medicine & rehabilitation. 13: 16 A1 Journal article (refereed), original research -
Systemic inflammation induced changes in protein expression of ABC transporters and ionotropic glutamate receptor subunit 1 in the cerebral cortex of familial Alzheimer`s disease mouse model
Puris, Elena; Auriola, Seppo; Korhonen, Paula; Loppi, Sanna; Kanninen, Katja M; Malm, Tarja; Koistinaho, Jari; Gynther, Mikko. 2021. Journal of pharmaceutical sciences. 110: 3953-3962 A1 Journal article (refereed), original research -
Astrocyte remodeling in the beneficial effects of long-term voluntary exercise in Alzheimer's disease
Belaya, Irina; Ivanova, Mariia; Sorvari, Annika; Ilicic, Marina; Loppi, Sanna; Koivisto, Hennariikka; Varricchio, Alessandra; Tikkanen, Heikki; Walker, Frederick R; Atalay, Mustafa; Malm, Tarja; Grubman, Alexandra; Tanila, Heikki; Kanninen, Katja M. 2020. Journal of neuroinflammation. 17: 271 A1 Journal article (refereed), original research -
Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-ß from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy
Carare, RO; Aldea, R; Agarwal, N; Bacskai, BJ; Bechman, I; Boche, D; Bu, G; Bulters, D; Clemens, A; Counts, SE; de Leon, M; Eide, PK; Fossati, S; Greenberg, SM; Hamel, E; Hawkes, CA; Koronyo-Hamaoui, M; Hainsworth, AH; Holtzman, D; Ihara, M; et al [incl. Kanninen, K; Leinonen, V; Malm, T]. 2020. Alzheimer's & dementia : diagnosis, assessment & disease monitoring. 21: e12053 A1 Journal article (refereed), original research -
Disentangling the Amyloid Pathways: A Mechanistic Approach to Etiology
Malmberg, Maja; Malm, Tarja; Gustafsson, Oskar; Sturchio, Andrea; Graff, Caroline; Espay, Alberto J; Wright, Anthony P; El Andaloussi, Samir; Lindén, Anders; Ezzat, Kariem. 2020. Frontiers in neuroscience. 14: 256 A1 Journal article (refereed), original research -
Does Cholinergic Stimulation Affect the P2X7 Receptor-Mediated Dye Uptake in Mast Cells and Macrophages?
Nurkhametova, Dilyara; Siniavin, Andrei; Streltsova, Maria; Kudryavtsev, Denis; Kudryavtsev, Igor; Giniatullina, Raisa; Tsetlin, Victor; Malm, Tarja; Giniatullin, Rashid. 2020. Frontiers in cellular neuroscience. 14: 548376 A1 Journal article (refereed), original research -
Editorial: Air Pollution and Brain Health
White, Anthony; Kanninen, Katja; Malm, Tarja; Schins, Roel. 2020. Neurochemistry international. 141: 104900 B1 Non-refereed journal articles -
Glial smog: Interplay between air pollution and astrocyte-microglia interactions
Gómez-Budia, Mireia; Konttinen, Henna; Saveleva, Liudmila; Korhonen, Paula; Jalava, Pasi; Kanninen, Katja; Malm, Tarja. 2020. Neurochemistry international. 136: 104715 A2 Review article, Literature review, Systematic review -
Hypoxia and extracellular vesicles: A review on methods, vesicular cargo and functions
Bister, Nea; Pistono, Cristiana; Huremagic, Benjamin; Jolkkonen, Jukka; Giugno, Rosalba; Malm, Tarja. 2020. Journal of extracellular vesicles. 10: e12002 A2 Review article, Literature review, Systematic review -
Impairment of mitochondrial function by particulate matter: Implications for the brain
Chew, S; Kolosowska, N; Saveleva, L; Malm, T; Kanninen, KM. 2020. Neurochemistry international. 135: 104694 A2 Review article, Literature review, Systematic review -
Intracerebral overexpression of miR-669c is protective in mouse ischemic stroke model by targeting MyD88 and inducing alternative microglial/macrophage activation
Kolosowska, Natalia; Gotkiewicz, Maria; Dhungana, Hiramani; Giudice, Luca; Giugno, Rosalba; Box, Daphne; Huuskonen, Mikko T.; Korhonen, Paula; Scoyni, Flavia; Kanninen, Katja M.; Ylä-Herttuala, Seppo; Turunen, Tiia A.; Turunen, Mikko P.; Koistinaho, Jari; Malm, Tarja. 2020. Journal of neuroinflammation. 17: 194 A1 Journal article (refereed), original research -
Peripheral inflammation preceeding ischemia impairs neuronal survival through mechanisms involving miR-127 in aged animals
Loppi, Sanna; Korhonen, Paula; Bouvy-Liivrand, Maria; Cagliola, Simone; Turunen, Tiia A; Turunen, Mikko P; Hernandez de Sande, Ana; Kolosowska, Natalia; Scoyni, Flavia; Rosell, Anna; García-Berrocoso, Teresa; Lemarchant, Sighild; Dhungana, Hiramani; Montaner, Joan; Koistinaho, Jari; Kanninen, Katja M; Kaikkonen, Minna U; Giugno, Rosalba; Heinäniemi, Merja; Malm, Tarja. 2020. Aging cell. 2021; 20: e13287 A1 Journal article (refereed), original research -
Urban air particulate matter induces mitochondrial dysfunction in human olfactory mucosal cells
Chew, Sweelin; Lampinen, Riikka; Saveleva, Liudmila; Korhonen, Paula; Mikhailov, Nikita; Grubman, Alexandra; Polo, Jose M; Wilson, Trevor; Komppula, Mika; Rönkkö, Teemu; Gu, Cheng; Mackay-Sim, Alan; Malm, Tarja; White, Anthony R; Jalava, Pasi; Kanninen, Katja M. 2020. Particle and fibre toxicology. 17: 18 A1 Journal article (refereed), original research -
Activation of P2X7 Receptors in Peritoneal and Meningeal Mast Cells Detected by Uptake of Organic Dyes: Possible Purinergic Triggers of Neuroinflammation in Meninges
Nurkhametova, Dilyara; Kudryavtsev, Igor; Guselnikova, Valeriia; Serebryakova, Maria; Giniatullina, Raisa R; Wojciechowski, Sara; Tore, Fatma; Rizvanov, Albert; Koistinaho, Jari; Malm, Tarja; Giniatullin, Rashid. 2019. Frontiers in cellular neuroscience. 13: 45 A1 Journal article (refereed), original research -
Changes in nuclear and cytoplasmic microRNA distribution in response to hypoxic stress
Turunen, TA; Roberts, TC; Laitinen, P; Väänänen, MA; Korhonen, P; Malm, T; Ylä-Herttuala, S; Turunen, M. 2019. Scientific reports. 9: 10332 A1 Journal article (refereed), original research -
Long-term interleukin-33 treatment delays disease onset and alleviates astrocytic activation in a transgenic mouse model of amyotrophic lateral sclerosis
Korhonen, P; Pollari, E; Kanninen, KM; Savchenko, E; Lehtonen, ¦; Wojciechowski; S; Pomeshchik, Y; Van Den Bosch, L; Goldsteins, G; Koistinaho, J; Malm, T. 2019. IBRO reports. 6: 74-86 A1 Journal article (refereed), original research -
Loss of Cln5 leads to altered Gad1 expression and deficits in interneuron development in mice
Singh, Y; Leinonen, H; Fazaludeen, F; Jaronen, M; Guest, D; Buckley, N; Byts, N; Oksa, P; Jalkanen, K; Iqbal, I; Huuskonen, M; Savchenko, E; Keksa-Goldsteine, V; Chew, S; Myllyharju, J; Tanila, H; Ooi, L; Koistinaho, J; Kanninen, KM; Malm, T. 2019. Human molecular genetics. 28: 3309-3322 A1 Journal article (refereed), original research -
Mechanosensitive meningeal nociception via Piezo channels: Implications for pulsatile pain in migraine?
Mikhailov, N; Leskinen, J; Fagerlund, I; Poguzhelskaya, E; Giniatullina, R; Gafurov, O; Malm, T; Karjalainen, T; Gröhn, O; Giniatullin, R. 2019. Neuropharmacology. 149: 113-123 A1 Journal article (refereed), original research -
Meningeal Mast Cells Contribute to ATP-Induced Nociceptive Firing in Trigeminal Nerve Terminals: Direct and Indirect Purinergic Mechanisms Triggering Migraine Pain
Koroleva, Ksenia; Gafurov, Oleg; Guselnikova, Valeriia; Nurkhametovez, Dilyara; Giniatullina, Raisa; Sitdikova, Guzel; Mattila, Olli S; Lindsberg, Perttu J; Malm, Tarja Maarit; Giniatullin, Rashid. 2019. Frontiers in cellular neuroscience. 13: 195 A1 Journal article (refereed), original research -
PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia
Konttinen, H; Cabral-da-Silva, MEC; Ohtonen, S; Wojciechowski, S; Shakirzyanova, A; Caligola, S; Giugno, R; Ishchenko, Y; Hernández, D; Fazaludeen, MF; Eamen, S; Budia, MG; Fagerlund, I; Scoyni, F; Korhonen, P; Huber, N; Haapasalo, A; Hewitt, AW; Vickers, J; Smith, GC; et al.. 2019. Stem cell reports. 13: 669-683 A1 Journal article (refereed), original research -
Peripheral Administration of IL-13 Induces Anti-inflammatory Microglial/Macrophage Responses and Provides Neuroprotection in Ischemic Stroke
Kolosowska, N; Keuters, MH; Wojciechowski, S; Keksa-Goldsteine, V; Laine, M; Malm, T; Goldsteins, G; Koistinaho, J; Dhungana, H. 2019. Neurotherapeutics. 16: 1304-1319 A1 Journal article (refereed), original research -
Peripheral inflammatory markers and clinical correlations in patients with frontotemporal lobar degeneration with and without the C9orf72 repeat expansion
Katisko, K; Solje, E; Korhonen, P; Jääskeläinen, O; Loppi, S; Hartikainen, P; Koivisto, AM; Kontkanen, A; Korhonen, VE; Helisalmi, S; Malm, T; Herukka, SK; Remes, AM; Haapasalo, A. 2019. Journal of neurology. 2020; 267: 76-86 A1 Journal article (refereed), original research -
The viral protein corona directs viral pathogenesis and amyloid aggregation
Ezzat, K; Pernemalm, M; Pålsson, S; Roberts, TC; Järver, P; Dondalska, A; Bestas, B; Sobkowiak, MJ; Levänen, B; Sköld, M; Thompson, EA; Saher, O; Kari, OK; Lajunen, T; Sverremark Ekström, E; Nilsson, C; Ishchenko, Y; Malm, T; Wood, MJA; Power, UF; et al.. 2019. Nature communications. 10: 2331 A1 Journal article (refereed), original research -
3D human brain cell models: New frontiers in disease understanding and drug discovery for neurodegenerative diseases
Korhonen, Paula; Malm, Tarja; White, Anthony R. 2018. Neurochemistry international. 120: 191-199 A1 Journal article (refereed), original research -
8th Kuopio Alzheimer Symposium From translational research to biomarkers, treatment and prevention strategies
Malm, Tarja; Trevisan, Davide. 2018. Publications of the University of Eastern Finland. Reports and studies in health sciences. . Itä-Suomen yliopisto D6 Edited professional book -
CuII(atsm) Attenuates Neuroinflammation
Choo, Xin Yi; Liddell, Jeffrey R; Huuskonen, Mikko T; Grubman, Alexandra; Moujalled, Diane; Roberts, Jessica; Kysenius, Kai; Patten, Lauren; Quek, Hazel; Oikari, Lotta E; Duncan, Clare; James, Simon A; McInnes, Lachlan E; Hayne, David J; Donnelly, Paul S; Pollari, Eveliina; Vähätalo, Suvi; Lejavová, Katarína; Kettunen, Mikko I; Malm, Tarja; et al. [Incl Koistinaho, Jari; Kanninen, Katja]. 2018. Frontiers in neuroscience. 12: 668 A1 Journal article (refereed), original research -
Genotyping and Frequency of PCSK9 Variations Among Hypercholesterolemic and Diabetic Subjects
Nuglozeh, Edem; Feroze Fazaludeen, Mohammad; Hasona, Nabil; Malm, Tarja; Mayor, Luisito B; Al-Hazmi, Awdah; Ashankyty, Ibraheem. 2018. Indian Journal of Clinical Biochemistry. 2019; 34: 444-450 B1 Non-refereed journal articles -
HX600, a synthetic agonist for RXR-Nurr1 heterodimer complex, prevents ischemia-induced neuronal damage
Loppi, S; Kolosowska, N; Kärkkäinen, O; Korhonen, P; Huuskonen, M; Grubman, A; Dhungana, H; Wojciechowski, S; Pomeshchik, Y; Giordano, M; Kagechika, H; White, A; Auriola, S; Koistinaho, J; Landreth, G; Hanhineva, K; Kanninen, K; Malm, T. 2018. Brain behavior and immunity. 73: 670-681 A1 Journal article (refereed), original research -
Mitochondrial Function in Alzheimer's Disease: Focus on Astrocytes
Lampinen, Riikka; Belaya, Irina; Boccuni, Isabella; Malm, Tarja; Kanninen, Katja M. Teoksessa: Gentile, Maria Teresa(toim.) , 2018. Astrocyte: Physiology and Pathology. s. 139-162. InTech Open A3 Book section, Chapters in research books -
PPARß/DELTA-agonist GW0742 ameliorates dysfunction in fatty acid oxidation in PSEN1deltaE9 astrocytes
Konttinen, H; Gureviciene, I; Oksanen, M; Grubman, A; Loppi, S; Huuskonen, MT; Korhonen, P; Lampinen, R; Keuters, M; Belaya, I; Tanila, H; Kanninen, KM; Goldsteins, G; Landreth, G; Koistinaho, J; Malm, T. 2018. Glia. 2019; 67: 146-159 A1 Journal article (refereed), original research -
Purinergic Profiling of Regulatory T-cells in Patients With Episodic Migraine
Nurkhametova, Dilyara; Kudryavtsev, Igor; Khayrutdinova, Olga; Serebryakova, Maria; Altunbaev, Rashid; Malm, Tarja; Giniatullin, Rashid. 2018. Frontiers in cellular neuroscience. 12: 326 A1 Journal article (refereed), original research -
Sushi repeat-containing protein X-Linked 2 - a novel phylogenetically conserved hypothalamo-pituitary protein
Anwer, M; Bolkvadze, T; Ndode-Ekane, XE; Puhakka, N; Rauramaa, T; Leinonen, V; van Vliet, EA; Swaab, DF; Haapasalo, A; Leskelä, S; Bister, N; Malm, T; Carlson, S; Aronica, E; Pitkänen, A. 2018. Journal of comparative neurology. 526: 1806-1819 A1 Journal article (refereed), original research -
Targeting Nrf2 to Suppress Ferroptosis and Mitochondrial Dysfunction in Neurodegeneration
Abdalkader, Moataz; Lampinen, Riikka; Kanninen, Katja M; Malm, Tarja M; Liddell, Jeffrey R. 2018. Frontiers in neuroscience. 12: 466 A2 Review article, Literature review, Systematic review -
Augmentation of Anticancer Drug Efficacy in Murine Hepatocellular Carcinoma Cells by a Peripherally Acting Competitive N-Methyl-d-aspartate (NMDA) Receptor Antagonist
Gynther M, Proietti Silvestri I, Hansen JC, Hansen KB, Malm T, Ishchenko Y, Larsen Y, Han L, Kayser S, Auriola S, Petsalo A, Nielsen B, Pickering DS, Bunch L. 2017. Journal of medicinal chemistry. 60: 9885-9904 A1 Journal article (refereed), original research -
DHCR24 exerts neuroprotection upon inflammation-induced neuronal death
Martiskainen H, Paldanius KMA, Natunen T, Takalo M, Marttinen M, Leskelä S, Huber N, Mäkinen P, Bertling E, Dhungana H, Huuskonen M, Honkakoski P, Hotulainen P, Rilla K, Koistinaho J, Soininen H, Malm T, Haapasalo A, Hiltunen M. 2017. Journal of neuroinflammation. : 215 A1 Journal article (refereed), original research -
Disease-Induced Alterations in Brain Drug Transporters in Animal Models of Alzheimer's Disease
Vellonen KS, Ihalainen J, Boucau M-C, Gosselet F, Picardat T, Gynther M, Kanninen KM, White AR, Malm T, Koistinaho J, Forsberg MM, Ruponen M. 2017. Pharmaceutical research. 34: 2652-2662 A1 Journal article (refereed), original research -
Disease-modifying effect of atipamezole in a model of post-traumatic epilepsy
Nissinen J, Andrade P, Natunen T, Hiltunen M, Malm T, Kanninen K, Soares JI, Shatilloa O, Sallinen J, Ndode-Ekanea XE, Pitkänen A. 2017. Epilepsy research. 136: 18-34 A1 Journal article (refereed), original research -
Lack of collagen XV is protective after ischemic stroke in mice
Dhungana Hiramani, Huuskonen Mikko T, Pihlajaniemi Taina, Heljasvaara Ritva, Vivien Denis, Kanninen Katja M, Malm Tarja, Koistinaho Jari, Lemarchant Sighild. 2017. Cell death and disease. 8: 1-8 A1 Journal article (refereed), original research -
Loss of CLN5 causes altered neurogenesis in a childhood neurodegenerative disorder
Savchenko E, Singh Y, Konttinen H, Lejavova K, Mediavilla Santos L, Grubman A, Kärkkäinen V, Keksa-Goldsteine V, Naumenko N, Tavi P, White AR, Malm TM, Koistinaho J, Kanninen KM. 2017. Disease models and mechanisms. 10: 1089-1100 A1 Journal article (refereed), original research -
Metals and lysosomal storage disorders
Konttinen Henna, Lejavová Katarína, Malm Tarja, Kanninen Katja M. Teoksessa: White Anthony R, Aschner Michael, Costa Lucio G, Bush Ashley I(toim.) , 2017. Biometals in neurodegenerative diseases : mechanisms and therapeutics. s. 195-215. Academic press A3 Book section, Chapters in research books -
Neuronally-directed effects of RXR activation in a mouse model of Alzheimer's disease
Mariani MM, Malm T, Lamb R, Jay TR, Neilson L, Casali B, Medarametla L, Landreth GE. 2017. Scientific reports. 7: 42270 A1 Journal article (refereed), original research -
Psychosocial stress on neuroinflammation and cognitive dysfunctions in Alzheimer's diseasethe emerging role for microglia?
Piirainen S, Youssef A, Song C, Kalueff AV, Landreth GE, Malm T, Tian L. 2017. Neuroscience and biobehavioral reviews. 77: 148-164 A2 Review article, Literature review, Systematic review -
Retinal Degeneration In A Mouse Model Of CLN5 Disease Is Associated With Compromised Autophagy
Leinonen Henri, Keksa-Goldsteine Velta, Ragauskas Symantas, Kohlmann Philip, Signh Yajuvinder, Savchencko Ekaterina, Puranen Jooseppi, Malm Tarja, Kalesnykas Giedrius, Koistinaho Jari, Tanila Heikki, Kanninen Katja M. 2017. Scientific reports. 7: 1597 A1 Journal article (refereed), original research -
Sulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke-induced neuroinflammation
Dhungana H, Huuskonen MT, Jaronen M, Lemarchant S, Ali H, Keksa-Goldsteine V, Goldsteins G, Kanninen KM, Koistinaho J, Malm T. 2017. Journal of neuroinflammation. 14: 237 A1 Journal article (refereed), original research -
The Copper bis(thiosemicarbazone) Complex Cu(II)(atsm) Is Protective Against Cerebral Ischemia Through Modulation of the Inflammatory Milieu
Huuskonen, MT; Tuo, QZ; Loppi, S; Dhungana, H; Korhonen, P; McInnes, LE; Donnelly, PS; Grubman, A; Wojciechowski, S; Lejavova, K; Pomeshchik, Y; Periviita, L; Kosonen, L; Giordano, M; Walker, FR; Liu, R; Bush, AI; Koistinaho, J; Malm, T; White, AR; et al.. 2017. Neurotherapeutics. 14: 519-532 A1 Journal article (refereed), original research -
ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis
Lemarchant S, Pomeshchik Y, Kidin I, Kärkkäinen V, Valonen P, Lehtonen S, Goldsteins G, Malm T, Kanninen K, Koistinaho J. 2016. Molecular neurodegeneration. 11: 10 A1 Journal article (refereed), original research -
Anti-inflammatory effects of ADAMTS-4 in a mouse model of ischemic stroke
Lemarchant S, Dunghana H, Pomeshchik Y, Leinonen H, Kolosowska N, Korhonen P, Kanninen KM, García-Berrocoso T, Montaner J, Malm T, Koistinaho J. 2016. Glia. 64: 1492-507 A1 Journal article (refereed), original research -
Aß and Inflammatory Stimulus Activate Diverse Signaling Pathways in Monocytic Cells: Implications in Retaining Phagocytosis in Aß-Laden Environment
Savchenko Ekaterina, Malm Tarja, Konttinen Henna, Hämäläinen Riikka H, Guerrero-Toro Cindy, Wojciechowski Sara, Giniatullin Rashid, Koistinaho Jari, Magga Johanna. 2016. Frontiers in cellular neuroscience. 10: 279 A1 Journal article (refereed), original research -
Bexarotene targets autophagy and is protective against thromboembolic stroke in aged mice with tauopathy
Huuskonen MT, Loppi S, Dhungana H, Keksa-Goldsteine V, Lemarchant S, Korhonen P, Wojciechowski S, Pollari E, Valonen P, Koponen J, Takashima A, Landreth G, Goldsteins G, Malm T, Koistinaho J, Kanninen KM. 2016. Scientific reports. 6: 33176 A1 Journal article (refereed), original research -
Eksosomit aivosairauksissa - solujenvälisen kommunikoinnin uusi muoto
Kanninen K, Malm T. 2016. Duodecim. 132: 1957-63 A1 Journal article (refereed), original research -
Erratum to: ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis
Lemarchant S, Pomeshchik Y, Kidin I, Kärkkäinen V, Valonen P, Lehtonen S, Goldsteins G, Malm T, Kanninen K, Koistinaho J. 2016. Molecular neurodegeneration. 11: 15 A1 Journal article (refereed), original research -
Exosomes in Alzheimer's disease
Malm Tarja, Loppi Sanna, Kanninen Katja M. 2016. Neurochemistry international. 97: 193-199 A1 Journal article (refereed), original research -
Multitasking Microglia and Alzheimer's Disease: Diversity, Tools and Therapeutic Targets
Grubman Alexandra, Kanninen Katja M, Malm Tarja. 2016. Journal of molecular neuroscience. 60: 390-404 A1 Journal article (refereed), original research -
Pro-nociceptive migraine mediator CGRP provides neuroprotection of sensory, cortical and cerebellar neurons via multi-kinase signaling
Abushik PA, Bart G, Korhonen P, Leinonen H, Giniatullina R, Sibarov DA, Levonen A-L , Malm T, Antonov SM, Giniatullin R. 2016. Cephalalgia. 2017; 37: 1373-1383 A1 Journal article (refereed), original research -
Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes
Liddell Jeffrey R, Lehtonen Sarka, Duncan Clare, Keksa-Goldsteine Velta, Levonen Anna-Liisa, Goldsteins Gundars, Malm Tarja, White Anthony R, Koistinaho Jari, Kanninen Katja M. 2016. Journal of neuroinflammation. 13: 1-14 A1 Journal article (refereed), original research -
A cross-laboratory preclinical study on the effectiveness of interleukin-1 receptor antagonist in stroke
Maysami Samaneh, Wong Raymond, Pradillo Jesus M, Denes Adam, Dhungana Hiramani, Malm Tarja, Koistinaho Jari, Orset Cyrille, Rahman Mahbubur, Rubio Marina, Schwaninger Markus, Vivien Denis, Bath Philip M, Rothwell Nancy J, Allan Stuart M. 2015. Journal of cerebral blood flow and metabolism. [epub ahead of print Sep 30, 2015]: - A1 Journal article (refereed), original research -
Activation of the nuclear receptor PPARdelta is neuroprotective in a transgenic mouse model of Alzheimer's disease through inhibition of inflammation
Malm Tarja, Mariani Monica, Donovan Lauren J, Neilson Lee, Landreth Gary E. 2015. Journal of neuroinflammation. 12: 15 p A1 Journal article (refereed), original research -
Applications of the Keap1-Nrf2 system for gene and cell therapy
Kanninen Katja M, Pomeshchik Yuriy, Leinonen Hanna, Malm Tarja, Koistinaho Jari, Levonen Anna-Liisa. 2015. Free radical biology and medicine. 88: 350-361 A2 Review article, Literature review, Systematic review -
Deletion of Nuclear Factor kappa B p50 Subunit Decreases Inflammatory Response and Mildly Protects Neurons from Transient Forebrain Ischemia-induced Damage
Rolova Taisia, Dhungana Hiramani, Korhonen Paula, Valonen Piia, Kolosowska Natalia, Konttinen Henna, Kanninen Katja, Tanila Heikki, Malm Tarja, Koistinaho Jari. 2015. Aging and disease. [epub ahead of print 3 Dec 2015]: - A1 Journal article (refereed), original research -
Exosomes as new diagnostic tools in CNS diseases
Kanninen Katja M, Bister Nea, Koistinaho Jari, Malm Tarja. 2015. Biochimica et biophysica acta: molecular basis of disease. 2016; 1862: 403-410 A2 Review article, Literature review, Systematic review -
Immunomodulation by interleukin-33 is protective in stroke through modulation of inflammation
Korhonen Paula, Kanninen Katja M, Lehtonen Sarka, Lemarchant Sighild, Puttonen Katja A, Oksanen Minna, Dhungana Hiramani, Loppi Sanna, Pollari Eveliina, Wojciechowski Sara, Kidin Iurii, Garcia-Berrocoso Teresa, Giralt Dolors, Montaner Joan, Koistinaho Jan I, Malm Tarja. 2015. Brain behavior and immunity. 49: 322-336 A1 Journal article (refereed), original research -
Nuclear receptors license phagocytosis by trem2+ myeloid cells in mouse models of Alzheimer's disease
Savage Julie C, Jay Taylor, Goduni Elanda, Quigley Caitlin, Mariani Monica M, Malm Tarja, Ransohoff Richard M, Lamb Bruce T, Landreth Gary E. 2015. Journal of neuroscience. 35: 6532-6543 A1 Journal article (refereed), original research -
Interleukin-33 treatment reduces secondary injury and improves functional recovery after contusion spinal cord injury
Pomeshchik Y, Kidin I, Korhonen P, Savchenko E, Jaronen M, Lehtonen S, Wojciechowski S, Kanninen K, Koistinaho J, Malm T. 2014. Brain behavior and immunity. 2014 Aug 18 ePub ahead of print: -- A1 Journal article (refereed), original research -
Nrf2 regulates neurogenesis and protects neural progenitor cells against aß toxicity
Kärkkäinen Virve, Pomeshchik Yuriy, Savchenko Ekaterina, Dhungana Hiramani, Kurronen Antti, Lehtonen Sarka, Naumenko Nikolay, Tavi Pasi, Levonen Anna-Liisa, Yamamoto Masayaki, Malm Tarja, Magga Johanna, Kanninen Katja M, Koistinaho Jari. 2014. Stem cells. 32: 1904-1916 A1 Journal article (refereed), original research -
Nuclear receptors in neurodegenerative diseases
Skerrett R, Malm T, Landreth G. 2014. Neurobiology of disease. 72: 104-116 A2 Review article, Literature review, Systematic review -
Susceptibility to focal and global brain ischemia of Alzheimer mice displaying aß deposits: effect of immunoglobulin
Heikkinen Riikka, Malm Tarja, Heikkilä Janne, Muona Anu, Tanila Heikki, Koistinaho Milla, Koistinaho Jari. 2014. Aging and disease. 2014 Apr 1;5(2): 76-87 A1 Journal article (refereed), original research -
The Evolving Biology of Microglia in Alzheimer's Disease
Malm Tarja M, Jay Taylor R, Landreth Gary E. 2014. Neurotherapeutics. -: - A2 Review article, Literature review, Systematic review -
Transplanted human iPSC-derived neural progenitor cells do not promote functional recovery of pharmacologically immunosuppressed mice with contusion spinal cord injury
Pomeshchik Y, Puttonen KA, Kidin I, Ruponen M, Lehtonen S, Malm T, Akesson E, Hovatta O, Koistinaho J. 2014. Cell transplantation. 2014 Sep 8. [Epub ahead of print]: - - A1 Journal article (refereed), original research -
Aging aggravates ischemic stroke-induced brain damage in mice with chronic peripheral infection
Dhungana H, Malm T, Denes A, Valonen P, Wojciechowski S, Magga J, Savchenko E, Humphreys N, Grencis R, Rothwell N, Koistinaho J. 2013. Aging cell. : -- A1 Journal article (refereed), original research -
Complex regulation of acute and chronic neuroinflammatory responses in mouse models deficient for nuclear factor kappa B p50 subunit
Rolova T, Puli L, Magga J, Dhungana H, Kanninen K, Wojciehowski S, Salminen A, Tanila H, Koistinaho J, Malm T. 2013. Neurobiology of disease. [Epub ahead of print]: 16-29 A1 Journal article (refereed), original research -
Does Nrf2 Gene Transfer Facilitate Recovery After Contusion Spinal Cord Injury?
Pomeshchik Y, Kidin I, Savchenko E, Rolova T, Yamamoto M, Levonen AL, Ylä-Herttuala S, Malm T, Kanninen K, Koistinaho J. 2013. Antioxidants and redox signaling. 2013 Aug 20. [Epub ahead of print]: x-x A1 Journal article (refereed), original research -
Western-type diet modulates inflammatory responses and impairs functional outcome following permanent middle cerebral artery occlusion in aged mice expressing the human apolipoprotein E4 allele
Dhungana H, Rolova T, Savchenko E, Wojciechowski S, Savolainen K, Ruotsalainen AK, Sullivan PM, Koistinaho J, Malm T. 2013. Journal of neuroinflammation. 2013 Aug 20;10(1):102: -- A1 Journal article (refereed), original research -
Animal Models of Alzheimer's Disease: Utilization of Transgenic Alzheimer's Disease Models in Studies of Amyloid Beta Clearance
Malm T, Magga J, Koistinaho J. 2012. Current translational geriatrics and experimental gerontology reports. - -: - - A1 Journal article (refereed), original research -
Brain Environment and Alzheimer's Disease Mutations Affect the Survival, Migration and Differentiation of Neural Progenitor Cells
Kärkkäinen V, Magga J, Koistinaho J, Malm T. 2012. Current alzheimer research. 2012 Aug 30. [Epub ahead of print]: -- A1 Journal article (refereed), original research -
Effects of human intravenous immunoglobulin on amyloid pathology and neuroinflammation in a mouse model of Alzheimer's disease
Puli L, Pomeshchik Y, Olas K, Malm T, Koistinaho J, Tanila H. 2012. Journal of neuroinflammation. 2012 May 29;9:105: - - A1 Journal article (refereed), original research -
Production of monocytic cells from bone marrow stem cells: therapeutic usage in Alzheimer's disease
Magga J, Savchenko E, Malm T, Rolova T, Pollari E, Valonen P, Lehtonen S, Jantunen E, Aarnio J, Lehenkari P, Koistinaho M, Muona A, Koistinaho J. 2012. Journal of cellular and molecular medicine. 2012 May;16(5): 1060-73 A1 Journal article (refereed), original research -
Protein Disulfide Isomerase in ALS Mouse Glia Links Protein Misfolding with NADPH Oxidase Catalyzed Superoxide Production
Jaronen M, Vehviläinen P, Malm T, Keksa-Goldsteine V, Pollari E, Valonen P, Koistinaho J, Goldsteins G. 2012. Human molecular genetics. 2012 Nov 1. [Epub ahead of print]: - - A1 Journal article (refereed), original research -
Glycogen synthase kinase-3β : a mediator of inflammation in Alzheimer's disease?
Koistinaho J, Malm T, Goldsteins G. 2011. International journal of alzheimers disease. : -- A2 Review article, Literature review, Systematic review -
Granulocyte colony stimulating factor attenuates inflammation in a mouse model of amyotrophic lateral sclerosis
Pollari Eveliina, Savchenko Ekaterina, Jaronen Merja, Kanninen Katja, Malm Tarja, Wojciechowski Sara, Ahtoniemi Toni, Goldsteins Gundars, Giniatullina Raisa, Giniatullin Rashid, Koistinaho Jari, Magga Johanna. 2011. Journal of neuroinflammation. 84: 1-14 A1 Journal article (refereed), original research -
Targeting Glycogen Synthase Kinase-3β for Therapeutic Benefit against Oxidative Stress in Alzheimer's Disease: Involvement of the Nrf2-ARE Pathway
Kanninen K, White AR, Koistinaho J, Malm T. 2011. International journal of alzheimers disease. : -- A2 Review article, Literature review, Systematic review -
Utilization of APPswe/PS1dE9 Transgenic Mice in Research of Alzheimer's Disease: Focus on Gene Therapy and Cell-Based Therapy Applications
Malm T, Koistinaho J, Kanninen K. 2011. International journal of alzheimers disease. : -- A2 Review article, Literature review, Systematic review -
Human intravenous immunoglobulin provides protection against Aβ toxicity by multiple mechanisms in a mouse model of Alzheimer's disease
Magga J, Puli L, Pihlaja R, Kanninen K, Neulamaa S, Malm T, Härtig W, Grosche J, Goldsteins G, Tanila H et al. 2010. Journal of neuroinflammation. 7: 90 A1 Journal article (refereed), original research -
The role and therapeutic potential of monocytic cells in Alzheimer's disease
Malm T, Koistinaho M, Muona A, Magga J & Koistinaho J. 2010. Glia. 58: 889-900 A1 Journal article (refereed), original research -
Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease
Kanninen K, Heikkinen R, Malm T, Rolova T, Kuhmonen S, Leinonen H, Ylä-Herttuala S, Tanila H, Levonen AL, Koistinaho M, Koistinaho J. 2009. Proceedings of the National Academy of Sciences of the United States of America. 106: 16505-16510 A1 Journal article (refereed), original research -
Age-related decrease in stimulated glutamate release and vesicular glutamate transporters in APP/PS1 transgenic and wild-type mice
Minkeviciene R, Ihalainen J, Malm T, Matilainen O, Keksa-Goldsteine V, Goldsteins G, Iivonen H, Leguit N, Glennon J, Koistinaho J, Banerjee P, Tanila H. 2008. Journal of neurochemistry. 105: 584-594 A1 Journal article (refereed), original research -
Hypoxia induces microRNA miR-210 in vitro and in vivo ephrin-A3 and neuronal pentraxin 1 are potentially regulated by miR-210
Pulkkinen K, Malm T, Turunen M, Koistinaho J, Ylä-Herttuala S. 2008. Febs letters. 582: 2397-2401 A1 Journal article (refereed), original research -
Nuclear factor erythroid 2-related factor 2 protects against beta amyloid
Kanninen K, Malm TM, Jyrkkänen HK, Goldsteins G, Keksa-Goldsteine V, Tanila H, Yamamoto M, Ylä-Herttuala S, Levonen AL, Koistinaho J. 2008. Molecular and cellular neuroscience. 39: 302-313 A1 Journal article (refereed), original research -
Transplanted astrocytes internalize deposited beta-amyloid peptides in a transgenic mouse model of Alzheimer's disease
Pihlaja R, Koistinaho J, Malm T, Sikkilä H, Vainio S, Koistinaho M. 2008. Glia. 56: 154-163 A1 Journal article (refereed), original research -
Pyrrolidine dithiocarbamate activates akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden
Malm TM, Iivonen H, Goldsteins G, Keksa-Goldsteine V, Ahtoniemi T, Kanninen K, Salminen A, Auriola S, van Groen T, Tanila H, Koistinaho J. 2007. Journal of neuroscience. 27: 3712-3721 A1 Journal article (refereed), original research -
Pyrrolidine dithiocarbamate inhibits induction of immunoproteasome and decreases survival in a rat model of amyotrophic lateral sclerosis
Ahtoniemi T, Goldsteins G, Keksa-Goldsteine V, Malm T, Kanninen K, Salminen A, Koistinaho J. 2007. Molecular pharmacology. 71: 30-37 A1 Journal article (refereed), original research -
Beta-amyloid infusion results in delayed and age-dependent learning deficits without role of inflammation or beta-amyloid deposits
Malm T, Ort M, Tähtivaara L, Jukarainen N, Goldsteins G, Puoliväli J, Nurmi A, Pussinen R, Ahtoniemi T, Miettinen T-K, Kanninen K, Leskinen S, Vartiainen N, Yrjänheikki J, Laatikainen R, Harris-White ME, Koistinaho M, Frautschy SA, Bures J. 2006. Proceedings of the National Academy of Sciences of the United States of America. 103: 8852-8857 A1 Journal article (refereed), original research -
Glial Cells in Alzheimer's Disease Models
Malm T. 2006. Kuopion yliopiston julkaisuja G.- A.I. Virtanen -instituutti G5 Doctoral dissertation (article) -
Stable RNA interference: comparison of U6 and H1 promoters in endothelial cells and in mouse brain
Mäkinen PI, Koponen JK, Kärkkäinen A-M, Malm TM, Pulkkinen KH, Koistinaho J, Turunen MP, Ylä-Herttuala S. 2006. Journal of gene medicine. 8: 433-441 A1 Journal article (refereed), original research -
Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to beta-amyloid deposition in APP/PS1 double transgenic Alzheimer mice
Malm TM, Koistinaho M, Pärepalo M, Vatanen T, Ooka A, Karlsson S, Koistinaho J. 2005. Neurobiology of disease. 18: 134-142 A1 Journal article (refereed), original research -
Minocycline protects against permanent cerebral ischemia in wild type but not in matrix metalloprotease-9-deficient mice
Koistinaho M, Malm TM, Kettunen MI, Goldsteins G, Starckx S, Kauppinen RA, Opdenakker G, Koistinaho J. 2005. Journal of cerebral blood flow and metabolism. 25: 460-467 A1 Journal article (refereed), original research