Epilepsy Research

Tarkenna hakuasi

Tiedot Ihmiset Julkaisut

Johtajat

Asla Pitkänen

Professori

A.I. Virtanen -instituutti, Terveystieteiden tiedekunta

Epilepsy research -tutkimusryhmän tavoitteena on ymmärtää epileptogeneesin molekyyli- ja solumekanismeja traumaattisen aivovamman jälkeen,
sekä kehittää toimenpiteitä epileptogeneesin estämiseksi tai taudin vakavuuden lievittämiseksi.

Tarkempia tietoja Connectin englanninkieliseltä puolelta.

Johtajat

Asla Pitkänen

Professori

A.I. Virtanen -instituutti, Terveystieteiden tiedekunta

Vanhemmat tutkijat

Noora Puhakka

Projektitutkija

A.I. Virtanen -instituutti, Terveystieteiden tiedekunta

Tutkijatohtorit

Väitöskirjatutkijat

Teknikot

Tukihenkilöstö

Eleonora Niskanen

Project Controller

Talouspalvelut, Yliopistopalvelut

Projektitutkija

Elina Hämäläinen

Projektitutkija

A.I. Virtanen -instituutti, Terveystieteiden tiedekunta

Muut ryhmän jäsenet

Johanna Hiltunen [email protected]
Tomi Paananen [email protected]

Julkaisut

49 kappaletta

Tarkenna hakuasi

Johtajat

Asla Pitkänen

Johtajat

Asla Pitkänen

Vanhemmat tutkijat

Noora Puhakka

Tutkijatohtorit

Jenni Kyyriäinen

Anssi Lipponen

Väitöskirjatutkijat

Mette Heiskanen

Pedro Andrade de Abreu

Teknikot

Jarmo Hartikainen

Merja Lukkari

Tukihenkilöstö

Eleonora Niskanen

Projektitutkija

Elina Hämäläinen

Muut ryhmän jäsenet

Biomarkers for posttraumatic epilepsy

A Computational Diffusion MRI Framework for Biomarker Discovery in a Rodent Model of Post-Traumatic Epileptogenesis

Biomarkers For Epileptogenesis And Its Treatment

Chronic Regulation of miR-124-3p in the Perilesional Cortex After Experimental and Human TBI

Droplet digital polymerase chain reaction-based quantification of circulating microRNAs using small RNA concentration normalization

Early increase in cortical T2 relaxation is a prognostic biomarker for the evolution of severe cortical damage, but not for epileptogenesis, after experimental traumatic brain injury

Elevated acute plasma miR-124-3p level relates to evolution of larger cortical lesion area after traumatic brain injury

Increased expression of miR142 and miR155 in glial and immune cells after traumatic brain injury may contribute to neuroinflammation via astrocyte activation

Kainate receptors regulate development of glutamatergic synaptic circuitry in the rodent amygdala

Long-lasting blood-brain barrier dysfunction and neuroinflammation after traumatic brain injury

Plau/Plaur double-deficiency did not worsen lesion severity or vascular integrity after traumatic brain injury

Postinjury weight rather than cognitive or behavioral impairment predicts development of posttraumatic epilepsy after lateral fluid-percussion injury in rats

The role of the platelet-derived growth factor receptor B and the urokinase-type plasminogen activator receptor in brain injury pathology

Acute downregulation of novel hypothalamic protein sushi repeat-containing protein X-Linked 2 (SRPX2) after experimental traumatic brain injury

Acute non-convulsive status epilepticus after experimental traumatic brain injury in rats

Advancing research toward faster diagnosis, better treatment, and end of stigma in epilepsy

Common data elements (CDEs) for preclinical epilepsy research: Introduction to CDEs and description of core CDEs. A TASK3 report of the ILAE/AES joint translational task force

Deficiency of urokinase-type plasminogen activator and its receptor affects social behavior and increases seizure susceptibility

Dynamics of clusterin protein expression in the brain and plasma following experimental traumatic brain injury

Epilepsy biomarkers - Toward etiology and pathology specificity

Extracellular Vesicles as Diagnostics and Therapeutics for Structural Epilepsies

Genotype and Injury Effect on the Expression of a Novel Hypothalamic Protein Sushi Repeat-Containing Protein X-Linked 2 (SRPX2)

Harmonization of lateral fluid-percussion injury model production and post-injury monitoring in a preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis

Harmonization of pipeline for detection of HFOs in a rat model of post-traumatic epilepsy in preclinical multicenter study on post-traumatic epileptogenesis

Harmonization of pipeline for preclinical multicenter MRI biomarker discovery in a rat model of post-traumatic epileptogenesis

Harmonization of the pipeline for seizure detection to phenotype post-traumatic epilepsy in a preclinical multicenter study on post-traumatic epileptogenesis

In Vitro and In Vivo Pipeline for Validation of Disease-Modifying Effects of Systems Biology-Derived Network Treatments for Traumatic Brain Injury - Lessons Learned

Lateral fluid-percussion injury leads to pituitary atrophy in rats

MRS Reveals Chronic Inflammation in T2w MRI-Negative Perilesional Cortex - A 6-Months Multimodal Imaging Follow-Up Study

Preclinical common data elements (CDEs) for epilepsy: A joint ILAE/AES and NINDS translational initiative

Preface - Practical and theoretical considerations for performing a multi-center preclinical biomarker discovery study of post-traumatic epileptogenesis: lessons learned from the EpiBioS4Rx consortium

Visualization of thalamic calcium influx with quantitative susceptibility mapping as a potential imaging biomarker for repeated mild traumatic brain injury

Web Application for Quantification of Traumatic Brain Injury-Induced Cortical Lesions in Adult Mice

A web-based application for generating 2D-unfolded cortical maps to analyze the location and extent of cortical lesions following traumatic brain injury in adult rats

Age- and quality-dependent DNA methylation correlate with melanin-based coloration in a wild bird

Algorithm for automatic detection of spontaneous seizures in rats with post-traumatic epilepsy

Analytic Tools for Post-traumatic Epileptogenesis Biomarker Search in Multimodal Dataset of an Animal Model and Human Patients

Big data sharing and analysis to advance research in post-traumatic epilepsy

Detection of Hyperexcitability by fMRI After Experimental Traumatic Brain Injury

Early seizures and temporal lobe trauma predict post-traumatic epilepsy: A longitudinal study

Effect of resource availability on evolution of virulence and competition in an environmentally transmitted pathogen

Epilepsy in neuropathologically verified Alzheimer's disease

Harmonization of pipeline for preclinical multicenter plasma protein and miRNA biomarker discovery in a rat model of post-traumatic epileptogenesis

Informatics tools to assess the success of procedural harmonization in preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis

Precipitation-based extracellular vesicle isolation from rat plasma co-precipitate vesicle-free microRNAs

Sushi repeat-containing protein X-Linked 2 - a novel phylogenetically conserved hypothalamo-pituitary protein

T-cell infiltration into the perilesional cortex is long-lasting and associates with poor somatomotor recovery after experimental traumatic brain injury

Transcription factors Tp73, Cebpd, Pax6, and Spi1 rather than DNA methylation regulate chronic transcriptomics changes after experimental traumatic brain injury

miR-124-3p is a chronic regulator of gene expression after brain injury