ALEJANDRA SIERRA LOPEZ

Yhteystiedot

Tutkimusryhmät - UEF

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  Neuro-Innovation

Julkaisut

• Abdollahzadeh, Ali; Belevich, Ilya; Jokitalo, Eija; Sierra, Alejandra; Tohka, Jussi. 2021. DeepACSON automated segmentation of white matter in 3D electron microscopy Communications biology 4 1: 179. 2021
• Ahl, Matilda; Avdic, Una; Chary, Karthik; Shibata, Keisuke; Chugh, Deepti; Lindén Mickelsson, Pernilla; Kettunen, Mikko; Compagno Strandberg, Maria; Johansson, Ulrica Englund; Sierra, Alejandra; Ekdahl, Christine T. 2021. Inflammatory reaction in the retina after focal non-convulsive status epilepticus in mice investigated with high resolution magnetic resonance and diffusion tensor imaging Epilepsy research 176: 106730. 2021
• Chary Karthik, Narvaez Omar, Salo Raimo A, San Martín Molina Isabel, Tohka Jussi, Aggarwal Manisha, Gröhn Olli, Sierra Alejandra. 2021. Microstructural Tissue Changes in a Rat Model of Mild Traumatic Brain Injury Frontiers in neuroscience 15: 746214. 2021
• De Feo, Riccardo; Shatillo, Artem; Sierra, Alejandra; Valverde, Juan Miguel; Gröhn, Olli; Giove, Federico; Tohka, Jussi. 2021. Automated joint skull-stripping and segmentation with Multi-Task U-Net in large mouse brain MRI databases Neuroimage 229: 117734. 2021
• Holikova, Klara; Laakso, Hanne; Salo, Raimo; Shatillo, Artem; Nurmi, Antti; Bares, Martin; Vanicek, Jiri; Michaeli, Shalom; Mangia, Silvia; Sierra, Alejandra; Gröhn, Olli. 2021. RAFF-4, Magnetization Transfer and Diffusion Tensor MRI of Lysophosphatidylcholine Induced Demyelination and Remyelination in Rats Frontiers in neuroscience 15: 625167. 2021
• Laakso, Hanne; Ylä-Herttuala, Elias; Sierra, Alejandra; Jambor, Ivan; Poutanen, Matti; Liljenbäck, Heidi; Virtanen, Helena; Merisaari, Harri; Aronen, Hannu; Minn, Heikki; Roivainen, Anne; Liimatainen, Timo. 2021. Docetaxel chemotherapy response in PC3 prostate cancer mouse model detected by rotating frame relaxations and water diffusion Nmr in biomedicine 34 4: e4483. 2021
• Manninen, Eppu; Chary, Karthik; Lapinlampi, Niina; Andrade, Pedro; Paananen, Tomi; Sierra, Alejandra; Tohka, Jussi; Gröhn, Olli; Pitkänen, Asla. 2021. Acute thalamic damage as a prognostic biomarker for post-traumatic epileptogenesis Epilepsia 62 8: 1852-1864. 2021
• Miocchi, Paolo; Sierra, Alejandra; Maugeri, Laura; Stefanutti, Eleonora; Abdollahzadeh, Ali; Mangini, Fabio; Moraschi, Marta; Bukreeva, Inna; Massimi, Lorenzo; Brun, Francesco; Tohka, Jussi; Gröhn, Olli; Mittone, Alberto; Bravin, Alberto; Nicaise, Charles; Giove, Federico; Cedola, Alessia; Fratini, Michela. 2021. Steerable3D: An ImageJ plugin for neurovascular enhancement in 3-D segmentation Physica medica 81: 197-209. 2021
• Abdollahzadeh, Ali; Sierra, Alejandra; Tohka, Jussi. 2021. Cylindrical Shape Decomposition for 3D Segmentation of Tubular Objects IEEE access 9: 23979-23995. 2021
• Salo, Raimo A; Belevich, Ilya; Jokitalo, Eija; Gröhn, Olli; Sierra, Alejandra. 2020. Assessment of the structural complexity of diffusion MRI voxels using 3D electron microscopy in the rat brain Neuroimage 225: 117529. 2020
• San Martín Molina, Isabel; Salo, Raimo A; Abdollahzadeh, Ali; Tohka, Jussi; Gröhn, Olli; Sierra, Alejandra. 2020. In vivo diffusion tensor imaging in acute and subacute phases of mild traumatic brain injury in rats eNeuro 7 3: ENEURO.0476-19.2020. 2020
• Manninen, Eppu Matias; Chary, Karthik; Lapinlampi, Niina; Andrade, Pedro; Paananen, Tomi; Sierra Lopez, Alejandra; Tohka, Jussi; Gröhn, Olli; Pitkanen, Asla. 2020. Early increase in cortical T2 relaxation is a prognostic biomarker for the evolution of severe cortical damage, but not for epileptogenesis, after experimental traumatic brain injury Journal of neurotrauma 37 23: 2580-2594. 2020
• Lehto, Lauri; Canna, Antonietta; Wu, Lin; Sierra, Alejandra; Zhurakovskaya, E; Ma, Jun; Pearce, Clairice; Shaio, Maple; Filip, Pavel; Johnson, Matthew; Low, Walter; Gröhn, Olli; Tanila, Heikki; Mangia, Silvia; Michaeli, Shalom. 2020. Orientation selective deep brain stimulation of the subthalamic nucleus in rats Neuroimage 213: 116750. 2020
• Fratini, Michela; Abdollahzadeh, Ali; DiNuzzo, Mauro; Salo, Raimo; Maugeri, Laura; Cedola, Alessia; Giove, Federico; Gröhn, Olli; Tohka, Jussi; Sierra, Alejandra. 2020. Multiscale Imaging Approach for Studying the Central Nervous System: Methodology and Perspective Frontiers in neuroscience 14: 72. 2020
• Chary, Karthik; Nissi, Mikko J; Nykänen, Olli; Manninen, Eppu; Rey, Ramón I; Shmueli, Karin; Sierra, Alejandra; Gröhn, Olli. 2020. Quantitative susceptibility mapping of the rat brain after traumatic brain injury Nmr in biomedicine 2021; 34 2: e4438. 2020
• Bukreeva, I; Asadchikov, V; Buzmakov, A; Chukalina, M; Ingacheva, A; Korolev, NA; Bravin, A; Mittone, A; Biella, GEM; Sierra, A; Brun, F; Massimi, L; Fratini, M; Cedola, A. 2020. High resolution 3D visualization of the spinalcord in a post-mortem murine model Biomedical optics express 11 4: 2235-2253. 2020
• Abdollahzadeh, A; Belevich, I; Jokitalo, E; Tohka, J; Sierra, A. 2019. Automated 3D Axonal Morphometry of White Matter Scientific reports 9 1: 6084. 2019
• Automatic Rodent Brain MRI Lesion Segmentation with Fully Convolutional Networks. Valverde, JM; Shatillo, A; De Feo, R; Gröhn, O; Sierra, A; Tohka, J / Machine Learning in Medical Imaging. MLMI 2019. 2019. 2019
• Svobodova, H; Kosn, D; Balazsiova, Z; Tanila, H; Miettinen, P O; Sierra, A; Vitovic, P; Wagner, A; Polak, S; Kopani, M. 2019. Elevated Age-Related Cortical Iron, Ferritin and Amyloid Plaques in APP(swe)/PS1(Delta E9) Transgenic Mouse Model of Alzheimer's Disease Physiological research 68 Suppl. 4: S445-S451. 2019
• Avdic, Una; Ahl, Matilda; Chugh, Deepti; Ali, Idrish; Chary, Karthik; Sierra, Alejandra; Ekdahl, Christine T. 2018. Nonconvulsive status epilepticus in rats leads to brain pathology. EPILEPSIA (NY) 59 5: 945-958. 2018
• Huttunen, JK; Airaksinen, AM; Barba, C; Colicchio, G; Niskanen, JP; Shatillo, A; Sierra Lopez, A; Ndode-Ekane, XE; Pitkanen, A; Gröhn, O. 2018. Detection of Hyperexcitability by fMRI After Experimental Traumatic Brain Injury Journal of neurotrauma 35 22: 2708-2717. 2018
• Lehto, Lauri J; Filip, Pavel; Laakso, Hanne; Sierra, Alejandra; Slopsema, Julia P; Johnson, Matthew D; Eberly, Lynn E; Low, Walter C; Gröhn, Olli; Tanila, Heikki; Mangia, Silvia; Michael, Shalom. 2018. Tuning Neuromodulation Effects by Orientation Selective Deep Brain Stimulation in the Rat Medial Frontal Cortex Frontiers in Neuroscience 12: 899. 2018
• Salo, Raimo A; Belevich, Ilya; Manninen, Eppu; Jokitalo, Eija; Gröhn, Olli; Sierra, Alejandra. 2018. Quantification of anisotropy and orientation in 3D electron microscopy and diffusion tensor imaging in injured rat brain. NEUROIMAGE 172: 404-414. 2018
• Stefanutti, E; Sierra, A; Miocchi, P; Massimi, L; Brun, F; Maugeri, L; Bukreeva, I; Nurmi, A; Provinciali, G Begani; Tromba, G; Grohn, O; Giove, F; Cedola, A; Fratini, M. 2018. Assessment of the effects of different sample perfusion procedures on phase-contrast tomographic images of mouse spinal cord. Journal of Instrumentation 13: C03027. 2018
• Lehto Lauri J, Slopsema Julia P, Johnson Matthew D, Shatillo Artem, Teplitzky Benjamin A, Utecht Lynn, Adriany Gregor, Mangia Silvia, Sierra Alejandra, Low Walter C, Gröhn Olli, Michaeli Shalom. 2017. Orientation selective deep brain stimulation. Journal of Neural Engineering 14 1: 016016. 2017
• Salo RA, Miettinen T, Laitinen T, Gröhn O, Sierra A. 2017. Diffusion tensor MRI shows progressive changes in the hippocampus and dentate gyrus after status epilepticus in rat - histological validation with Fourier-based analysis. NEUROIMAGE 152: 221-236. 2017
• Lehto LJ, Sierra A, Gröhn O. 2017. Magnetization transfer SWIFT MRI consistently detects histologically verified myelin loss in the thalamocortical pathway after a traumatic brain injury in rat. NMR IN BIOMEDICINE 30 2: e3678. 2017
• Aggarwal M, Li X, Gröhn O, Sierra A. 2017. Nuclei-specific deposits of iron and calcium in the rat thalamus after status epilepticus revealed with quantitative susceptibility mapping (QSM). JOURNAL OF MAGNETIC RESONANCE IMAGING 2018; 47 2: 554-564. 2017
• Lehto Lauri J, Albors Aloma A. Sierra Alejandra, Tolppanen Laura, Eberly Lynn E, Mangia Silvia, Nurmi Antti, Michaeli Shalom, Gröhn Olli. 2017. Lysophosphatidyl Choline Induced Demyelination in Rat Probed by Relaxation along a Fictitious Field in High Rank Rotating Frame. Frontiers in Neuroscience 11: 433. 2017
• Gröhn Olli, Sierra Alejandra. 2017. Searching for epilepsy's crystal ball. Elife 6: e29853. 2017
• Abdurakhmanova Shamsiiat, Chary Karthik, Kettunen Mikko, Sierra Alejandra, Panula Pertti. 2017. Behavioral and stereological characterization of Hdc KO mice: Relation to Tourette syndrome. JOURNAL OF COMPARATIVE NEUROLOGY 525 16: 3476-3487. 2017
• McGarry BL, Rogers HJ, Knight MJ, Jokivarsi KT, Sierra A, Gröhn OHJ, Kauppinen RA. 2016. Stroke onset time estimation from multispectral quantitative magnetic resonance imaging in a rat model of focal permanent cerebral ischemia. INTERNATIONAL JOURNAL OF STROKE 11 6: 677-82. 2016
• Pirttimäki T, Salo RA, Shatillo A, Kettunen MI, Paasonen J, Sierra A, Jokivarsi K, Leinonen V, Andrade P, Quittek S, Pitkänen A, Gröhn O. 2016. Implantable RF-coil with multiple electrodes for long-term EEG-fMRI monitoring in rodents. JOURNAL OF NEUROSCIENCE METHODS 274: 154-163. 2016
• Hakkarainen Hanne, Sierra Alejandra, Mangia Silvia, Garwood Michael, Michaeli Shalom, Gröhn Olli, Liimatainen Timo. 2015. MRI relaxation in the presence of fictitious fields correlates with myelin content in normal rat brain. MAGNETIC RESONANCE IN MEDICINE first published online: 3 FEB 2015: 8 p. 2015
• Heidi Marjonen, Alejandra Sierra, Anna Nyman, Vladimir Rogojin, Olli Gröhn, Anni-Maija Linden, Sampsa Hautaniemi, Nina Kaminen-Ahola. 2015. Early maternal alcohol consumption alters hippocampal DNA methylation, gene expression and volume in a mouse model. PLOS ONE [ONLINE] 10 5: e0124931. 2015
• Laitinen Teemu, Sierra Alejandra, Bolkvadze Tamuna, Pitkänen Asla, Gröhn Olli. 2015. Diffusion tensor imaging detects chronic microstructural changes in white and gray matter after traumatic brain injury in rat. Frontiers in Neuroscience 9 Article 128: 12 p. 2015
• Sierra A, Gröhn O, Pitkänen A. 2015. Imaging microstructural damage and plasticity in the hippocampus during epileptogenesis. NEUROSCIENCE 309: 162-172. 2015
• Pitkänen A, Huusko N, Ndode-Ekane XE, Kyyriäinen J, Lipponen A, Lipsanen A, Sierra A, Bolkvadze T. 2014. Gender issues in antiepileptogenic treatments. NEUROBIOLOGY OF DISEASE (SAN DIEGO CA) 2014 Jun 6 ePub ahead of print: pii: S0969-9961(14)00163-6. 2014
• Pitkänen Asla, Kemppainen Samuli, Ndode-Ekane Xavier Ekolle, Huusko Noora, Huttunen Joanna K, Gröhn Olli, Immonen Riikka, Sierra Alejandra, Bolkvadze Tamuna. 2014. Posttraumatic epilepsy - Disease or comorbidity?. EPILEPSY & BEHAVIOR 2014 Feb 11. [Epub ahead of print]: --. 2014
• Niskanen JP, Airaksinen AM, Sierra A, Huttunen JK, Nissinen J, Karjalainen PA, Pitkänen A, Gröhn OH. 2013. Monitoring functional impairment and recovery after traumatic brain injury in rats by FMRI. JOURNAL OF NEUROTRAUMA (NEW YORK NY) 2013 Apr 1;30(7): 546-56. 2013
• Sierra A, Laitinen T, Gröhn O, Pitkänen A. 2013. Diffusion tensor imaging of hippocampal network plasticity. Brain structure & function 220 2: 781-801. 2013
• Kobow K, Auvin S, Jensen F, Löscher W, Mody I, Potschka H, Prince D, Sierra A, Simonato M, Pitkänen A, Nehlig A, Rho JM. 2012. Finding a better drug for epilepsy: Antiepileptogenesis targets. EPILEPSIA (NY) 2012 Nov;53(11): 1868-1876. 2012
• Lehto LJ, Sierra A, Corum CA, Zhang J, Idiyatullin D, Pitkänen A, Garwood M, Gröhn O. 2012. Detection of Calcifications In Vivo and Ex Vivo after Brain Injury in Rat Using SWIFT. NEUROIMAGE 2012 Jul 16;61(4): 761-72. 2012
• Gröhn O, Sierra A, Immonen R, Laitinen T, Lehtimäki K, Airaksinen A, Hayward N, Nairismagi J, Lehto L, Pitkänen A. 2011. Multimodal MRI assessment of damage and plasticity caused by status epilepticus in the rat brain EPILEPSIA (NY) 52(Suppl. 8): 57-60. 2011
• Liimatainen T, Sierra A, Hanson T, Sorce DJ, Ylä-Herttuala S, Garwood M, Michaeli S, Gröhn O. 2011. Glioma cell density in a rat gene therapy model gauged by water relaxation rate along a fictitious magnetic field. Magn. Reson. Med. 67; 269-277, 2012 MAGNETIC RESONANCE IN MEDICINE 2012 Jan;67(1) Epub 2011 Jun 30: 269-277. 2011
• Sierra Alejandra, Laitinen Teemu, Lehtimäki Kimmo, Rieppo Lassi, Pitkänen Asla, Gröhn Olli. 2011. Diffusion tensor MRI with tract-based spatial statistics and histology reveals undiscovered lesioned areas in kainate model of epilepsy in rat. Brain Structure and Function 216: 123-135. 2011
• Laitinen T, Sierra A, Pitkänen A & Gröhn O. 2010. Diffusion tensor MRI of axonal plasticity in the rat hippocampus. NEUROIMAGE 51: 251-530. 2010
• Kharatishvili I, Sierra A, Immonen RJ, Gröhn OHJ, Pitkänen A. 2009. Quantitative T2 mapping as a potential marker for the initial assessment of the severity of damage after traumatic brain injury in rat. EXPERIMENTAL NEUROLOGY 217: 154-164. 2009
• Immonen RJ, Kharatishvili I, Sierra A, Einula C, Pitkänen A, Gröhn OH. 2008. Manganese enhanced MRI detects mossy fiber sprouting rather than neurodegeneration, gliosis or seizure-activity in the epileptic rat hippocampus NEUROIMAGE 40: 1718-1730. 2008
• Sierra A, Michaeli S, Niskanen J-P, Valonen PK, Gröhn HI, Ylä-Herttuala S, Garwood M, Gröhn OH. 2008. Water spin dynamics during apoptotic cell death in glioma gene therapy probed by T1rho and T2rho. MAGNETIC RESONANCE IN MEDICINE 59: 1311-1319. 2008
• Kettunen MI, Sierra A, Närväinen MJ, Valonen PK, Ylä-Herttuala S, Kauppinen RA, Gröhn OHJ. 2007. Low spin-lock field T1 relaxation in the rotating frame as a sensitive MR imaging marker for gene therapy treatment response in rat glioma. RADIOLOGY 243: 796-803. 2007