Arto Urtti

Comprehensive ocular and systemic pharmacokinetics of dexamethasone after subconjunctival and intravenous injections in rabbits

Valtari, Annika; Posio, Susanna; Toropainen, Elisa; Balla, Anusha; Puranen, Jooseppi; Sadeghi, Amir; Ruponen, Marika; Ranta, Veli-Pekka; Vellonen, Kati-Sisko; Urtti, Arto; del Amo, Eva M. 2024. European journal of pharmaceutics and biopharmaceutics. 198:

Aldehyde oxidase 1 activity and protein expression in human, rabbit, and pig ocular tissues

Hammid, Anam; Fallon, John K; Vellonen, Kati Sisko; Lassila, Toni; Reinisalo, Mika; Urtti, Arto; Gonzalez, Francisco; Tolonen, Ari; Smith, Philip C; Honkakoski, Paavo. 2023. European journal of pharmaceutical sciences. 191: . 106603

Intravitreal CendR peptides target laser-induced choroidal neovascularization sites in mice

Puranen, Jooseppi; Korhonen, Sonja; Haugas, Maarja; Lingasamy, Prakash; Teesalu, Tambet; Subrizi, Astrid; Urtti, Arto; Ruponen, Marika; Reinisalo, Mika. 2023. Journal of controlled release. 360: 810-817

Mass spectrometry in ocular drug research

del Amo, Eva M.; Vellonen, Kati‐Sisko; Urtti, Arto; Terasaki, Tetsuya; Hammid, Anam; Honkakoski, Paavo; Auriola, Seppo. 2023. Mass spectrometry reviews. [First published: 02 August 2023]: 1-32

Paljon on muuttunut sitten 1970- ja 1980-lukujen

Urtti, Arto; Paronen, Petteri. 2023. Publications of the University of Eastern Finland. General series. 44: 61-64

Quantitative intravitreal pharmacokinetics in mouse as a step towards inter-species translation

Puranen, Jooseppi; Ranta, Veli-Pekka; Ruponen, Marika; Urtti, Arto; Sadeghi, Amir. 2023. Experimental eye research. 235:

Selective drug delivery to the retinal cells: Biological barriers and avenues

Ramsay, Eva; Lajunen, Tatu; Bhattacharya, Madhushree; Reinisalo, Mika; Rilla, Kirsi; Kidron, Heidi; Terasaki, Tetsuya; Urtti, Arto. 2023. Journal of controlled release. 361: 1-19

Tailoring surface properties of liposomes for dexamethasone intraocular administration

Al-Amin, M.D.; Mastrotto, Francesca; Subrizi, Astrid; Sen, Merve; Turunen, Tiina; Arango-Gonzalez, Blanca; Ueffing, Marius; Malfanti, Alessio; Urtti, Arto; Salmaso, Stefano; Caliceti, Paolo. 2023. Journal of controlled release. 354: 323-336

The prophylactic value of TNF‐α inhibitors against retinal cell apoptosis and optic nerve axon loss after corneal surgery or trauma

Paschalis, Eleftherios I; Zhou, Chengxin; Sharma, Jyoti; Dohlman, Thomas H; Kim, Sarah; Lei, Fengyang; Chodosh, James; Vavvas, Demetrios; Urtti, Arto; Papaliodis, George; Dohlman, Claes H. 2023. Acta ophthalmologica. [Epub ahead of print Oct 6 2023]: 1-14

Topical pharmacokinetics of brinzolamide suspensions in rabbits and variability analysis for sample size and design considerations

Naageshwaran, Vatsala; Bigonne, Hélène; Gum, Glenwood; Malla, Spundana; del Sol, Charity; Bon, Charles; Xu, Xiaoming; Vo, Anh; Smith, William; O'Reilly Beringhs, Andre; Kozak, Darby; Tan, Ming Liang; Babiskin, Andrew; Urtti, Arto; del Amo, Eva M.; Ranta, Veli Pekka. 2023. International journal of pharmaceutics. 642: . 123183

5-(Sulfamoyl)thien-2-yl 1,3-oxazole inhibitors of carbonic anhydrase II with hydrophilic periphery

Kalinin, Stanislav; Kovalenko, Alexander; Valtari, Annika; Nocentini, Alessio; Gureev, Maxim; Urtti, Arto; Korsakov, Mikhail; Supuran, Claudiu T.; Krasavin, Mikhail. 2022. Journal of enzyme inhibition and medicinal chemistry. 37: 1005-1011

A Novel Ferroptosis Inhibitor UAMC-3203, a Potential Treatment for Corneal Epithelial Wound

Balla, Anusha; Tran, Bao; Valtari, Annika; Steven, Philipp; Scarpellini, Camilla; Augustyns, Koen; Urtti, Arto; Vellonen, Kati-Sisko; Ruponen, Marika. 2022. Pharmaceutics. 2023; 15:

Activity and expression of carboxylesterases and arylacetamide deacetylase in human ocular tissues

Hammid, Anam; Fallon, John K; Lassila, Toni; Vieiro, Paula; Balla, Anusha; Gonzalez, Francisco; Urtti, Arto; Smith, Philip C; Tolonen, Ari; Honkakoski, Paavo. 2022. Drug metabolism and disposition. 50: 1483-1492

Antiangiogenic AAV2 gene therapy with a truncated form of soluble VEGFR-2 reduces the growth of choroidal neovascularization in mice after intravitreal injection

Puranen, Jooseppi; Koponen, Sanna; Nieminen, Tiina; Kanerva, Iiris; Kokki, Emmi; Toivanen, Pyry; Urtti, Arto; Ylä-Herttuala, Seppo; Ruponen, Marika. 2022. Experimental eye research. 224:

Comments on “Ocular Pharmacokinetics of Brimonidine Drug Delivery System in Monkeys and Translational Modeling for Selection of Dose and Frequency in Clinical Trials”

del Amo, Eva M; Urtti, Arto; Ranta, Veli-Pekka. 2022. Journal of pharmacology and experimental therapeutics. 383: 246-247

Imaging, quantitation and kinetic modelling of intravitreal nanomaterials

Sadeghi, Amir; Ruponen, Marika; Puranen, Jooseppi; Cao, Shoupeng; Ridolfo, Roxane; Tavakoli, Shirin; Toropainen, Elisa; Lajunen, Tatu; Ranta, Veli-Pekka; van Hest, Jan; Urtti, Arto. 2022. International journal of pharmaceutics. 621:

Improved ocular delivery of quercetin and resveratrol: A comparative study between binary and ternary cyclodextrin complexes

Krstić, Luna; Jarho, Pekka; Ruponen, Marika; Urtti, Arto; González-García, María J.; Diebold, Yolanda. 2022. International journal of pharmaceutics. 624:

Liposomal sunitinib for ocular drug delivery: A potential treatment for choroidal neovascularization

Tavakoli, Shirin; Puranen, Jooseppi; Bahrpeyma, Sina; Lautala, Veera E.; Karumo, Suvi; Lajunen, Tatu; del Amo, Eva M.; Ruponen, Marika; Urtti, Arto. 2022. International journal of pharmaceutics. 620:

Mechanisms of cellular retention of melanin bound drugs: Experiments and computational modeling

Bahrpeyma, Sina; Reinisalo, Mika; Hellinen, Laura; Auriola, Seppo; del Amo, Eva M; Urtti, Arto. 2022. Journal of controlled release. 348: 760-770

Ocular metabolism and distribution of drugs in the rabbit eye: Quantitative assessment after intracameral and intravitreal administrations

del Amo, Eva M.; Hammid, Anam; Tausch, Melanie; Toropainen, Elisa; Sadeghi, Amir; Valtari, Annika; Puranen, Jooseppi; Reinisalo, Mika; Ruponen, Marika; Urtti, Arto; Sauer, Achim; Honkakoski, Paavo. 2022. International journal of pharmaceutics. 613:

Pharmacoproteomics of Brain Barrier Transporters and Substrate Design for the Brain Targeted Drug Delivery

Huttunen, Kristiina M.; Terasaki, Tetsuya; Urtti, Arto; Montaser, Ahmed B.; Uchida, Yasuo. 2022. Pharmaceutical research. 39: 1363-1392

Quantitative pharmacokinetic analyses of anterior and posterior elimination routes of intravitreal anti-VEGF macromolecules using published human and rabbit data

Lamminsalo, Marko; Urtti, Arto; Ranta, Veli-Pekka. 2022. Experimental eye research. 222:

Swarms of chemically modified antiviral siRNA targeting herpes simplex virus infection in human corneal epithelial cells

Kalke, Kiira; Lund, Liisa M.; Nyman, Marie C.; Levanova, Alesia A.; Urtti, Arto; Poranen, Minna M.; Hukkanen, Veijo; Paavilainen, Henrik. 2022. PLoS pathogens. 18:

The Effect of Microbubble-Assisted Ultrasound on Molecular Permeability across Cell Barriers

Rousou, Charis; de Maar, Josanne; Qiu, Boning; van der Wurff-Jacobs, Kim; Ruponen, Marika; Urtti, Arto; Oliveira, Sabrina; Moonen, Chrit; Storm, Gert; Mastrobattista, Enrico; Deckers, Roel. 2022. Pharmaceutics. 14:

Topical pharmacokinetics of dexamethasone suspensions in the rabbit eye: Bioavailability comparison

Naageshwaran, Vatsala; Ranta, Veli-Pekka; Toropainen, Elisa; Tuomainen, Marjo; Gum, Glenwood; Xie, Enli; Bhoopathy, Siddhartha; Urtti, Arto; del Amo, Eva M. 2022. International journal of pharmaceutics. 615:

Understanding dexamethasone kinetics in the rabbit tear fluid: Drug release and clearance from solution, suspension and hydrogel formulations

Balla, Anusha; Ruponen, Marika; Valtari, Annika; Toropainen, Elisa; Tuomainen, Marjo; Alvarez-Lorenzo, Carmen; del Amo, Eva M.; Urtti, Arto; Vellonen, Kati-Sisko. 2022. European journal of pharmaceutics and biopharmaceutics. 172: 53-60

Biopharmaceutics of Topical Ophthalmic Suspensions: Importance of Viscosity and Particle Size in Ocular Absorption of Indomethacin

Toropainen, Elisa; Fraser-Miller, Sara J; Novakovic, Dunja; Del Amo, Eva M; Vellonen, Kati-Sisko; Ruponen, Marika; Viitala, Tapani; Korhonen, Ossi; Auriola, Seppo; Hellinen, Laura; Reinisalo, Mika; Tengvall, Unni; Choi, Stephanie; Absar, Mohammad; Strachan, Clare; Urtti, Arto. 2021. Pharmaceutics. 13: 452

Carboxylesterase Activities and Protein Expression in Rabbit and Pig Ocular Tissues

Hammid, Anam; Fallon, John K; Lassila, Toni; Salluce, Giulia; Smith, Philip C; Tolonen, Ari; Sauer, Achim; Urtti, Arto; Honkakoski, Paavo. 2021. Molecular pharmaceutics. 18: 1305-1316

Conformationally Constrained Peptides with High Affinity to the Vascular Endothelial Growth Factor

Guryanov, I; Korzhikov-Vlakh, V; Bhattacharya, M; Biondi, B; Masiero, G; Formaggio, F; Tennikova, T; Urtti, A. 2021. Journal of medicinal chemistry. 64: 10900-10907

Cowpea Chlorotic Mottle Virus-Like Particles as Potential Platform for Antisense Oligonucleotide Delivery in Posterior Segment Ocular Diseases

Pretto, Chiara; Tang, Miao; Chen, Mei; Xu, Heping; Subrizi, Astrid; Urtti, Arto; Hest, Jan CM. 2021. Macromolecular bioscience. 21: 2100095

Inhibition of prolyl oligopeptidase: A promising pathway to prevent the progression of age-related macular degeneration

Hellinen, Laura; Koskela, Ali; Vattulainen, Elina; Liukkonen, Mikko; Wegler, Christine; Treyer, Andrea; Handin, Niklas; Svensson, Richard; Myöhänen, Timo; Poso, Antti; Kaarniranta, Kai; Artursson, Per; Urtti, Arto. 2021. Biomedicine and pharmacotherapy. 2022; 146: 112501

Intravitreal Polymeric Nanocarriers with Long Ocular Retention and Targeted Delivery to the Retina and Optic Nerve Head Region

Junnuthula, Vijayabhaskarreddy; Sadeghi Boroujeni, Amir; Cao, Shoupeng; Tavakoli, Shirin; Ridolfo, Roxane; Toropainen, Elisa; Ruponen, Marika; van Hest, Jan CM; Urtti, Arto. 2021. Pharmaceutics. 13: 445

Magnetically Assisted Drug Delivery of Topical Eye Drops Maintains Retinal Function In Vivo in Mice

Bassetto M, Ajoy D, Poulhes F, Obringer C, Walter A, Messadeq N, Sadeghi A, Puranen J, Ruponen M, Kettunen M, Toropainen E, Urtti A, Dollfus H, Zelphati O, Marion V. 2021. Pharmaceutics. 13: 1650

Mucoadhesive properties of nanogels based on stimuli-sensitive glycosaminoglycan-graft-pNIPAAm copolymers

Pilipenko, Iuliia; Korzhikov-Vlakh, Viktor; Valtari, Annika; Anufrikov, Yurii; Kalinin, Stanislav; Ruponen, Marika; Krasavin, Mikhail; Urtti, Arto; Tennikova, Tatiana. 2021. International journal of biological macromolecules. 186: 864-872

Ocular pharmacokinetics of atenolol, timolol and betaxolol cocktail: tissue exposures in the rabbit eye

Fayyaz, Anam; Vellonen, Kati-Sisko; Ranta, Veli-Pekka; Toropainen, Elisa; Reinisalo, Mika; Valtari, Annika; Puranen, Jooseppi; D'Amico Ricci, Giuseppe; Heikkinen, Emma M.; Gardner, Iain; Ruponen, Marika; Urtti, Arto; Jamei, Masoud; del Amo, Eva M. 2021. European journal of pharmaceutics and biopharmaceutics. 166: 155-162

Oxidative Stress and Mitochondrial Damage in Dry Age-Related Macular Degeneration Like NFE2L2/PGC-1[alpha] -/- Mouse Model Evoke Complement Component C5a Independent of C3

Sridevi Gurubaran, Iswariyaraja; Heloterä, Hanna; Marry, Stephen; Koskela, Ali; Hyttinen, Juha MT; Paterno, Jussi J; Urtti, Arto; Chen, Mei; Xu, Heping; Kauppinen, Anu; Kaarniranta, Kai. 2021. Biology. 10: 622

Partitioning and Spatial Distribution of Drugs in Ocular Surface Tissues

Balla, Anusha; Auriola, Seppo; Grey, Angus C; Demarais, Nicholas J; Valtari, Annika; Heikkinen, Emma M; Toropainen, Elisa; Urtti, Arto; Vellonen, Kati-Sisko; Ruponen, Marika. 2021. Pharmaceutics. 13: 658

Peptide Inhibitors of Vascular Endothelial Growth Factor A: Current Situation and Perspectives

Guryanov, Ivan; Tennikova, Tatiana; Urtti, Arto. 2021. Pharmaceutics. 13: 1337

Pharmacokinetics of Pullulan–Dexamethasone Conjugates in Retinal Drug Delivery

Kicková, Eva; Sadeghi, Amir; Puranen, Jooseppi; Tavakoli, Shirin; Sen, Merve; Ranta, Veli-Pekka; Arango-Gonzalez, Blanca; Bolz, Sylvia; Ueffing, Marius; Salmaso, Stefano; Caliceti, Paolo; Toropainen, Elisa; Ruponen, Marika; Urtti, Arto. 2021. Pharmaceutics. 2022; 14:

Pharmacokinetics of intravitreal macromolecules: scaling between rats and rabbits

Sadeghi, Amir; Puranen, Jooseppi; Ruponen, Marika; Valtari, Annika; Subrizi, Astrid; Ranta, Veli-Pekka; Toropainen, Elisa; Urtti, Arto. 2021. European journal of pharmaceutical sciences. 159: 105720

Pullulan Based Bioconjugates for Ocular Dexamethasone Delivery

Kicková, Eva; Salmaso, Stefano; Mastrotto, Francesca; Caliceti, Paolo; Urtti, Arto. 2021. Pharmaceutics. 13: 791

Retinal neuroprotection by controlled release of a VCP inhibitor from self-assembled nanoparticles

Sen, Merve; Al-Amin, M.D.; Kicková, Eva; Sadeghi, Amir; Puranen, Jooseppi; Urtti, Arto; Caliceti, Paolo; Salmaso, Stefano; Arango-Gonzalez, Blanca; Ueffing, Marius. 2021. Journal of controlled release. 339: 307-320

Screening of chemical linkers for development of pullulan bioconjugates for intravitreal ocular

Balasso, Anna; Subrizi, Astrid; Salmaso, Stefano; Mastrotto, Francesca; Garofalo, Mariangela; Tang, Miao; Chen, Mei; Xu, Heping; Urtti, Arto; Caliceti, Paolo. 2021. European journal of pharmaceutical sciences. 161: 105785

Statins for the prevention of proliferative vitreoretinopathy: cellular responses in cultured cells and clinical statin concentrations in the vitreous

Mysore, Yashavanthi; del Amo, Eva M; Loukovaara, Sirpa; Hagström, Marja; Urtti, Arto; Kauppinen, Anu. 2021. Scientific reports. 11: 980

Ultrasound and Microbubbles for the Treatment of Ocular Diseases: From Preclinical Research towards Clinical Application

Rousou, Charis; Schuurmans, Carl C. L.; Urtti, Arto; Mastrobattista, Enrico; Storm, Gert; Moonen, Chrit; Kaarniranta, Kai; Deckers, Roel. 2021. Pharmaceutics. 13: 1782

Amphiphilic Polypeptides for VEGF siRNA Delivery into Retinal Epithelial Cells

Osipova, O; Sharoyko, V; Zashikhina, N; Zakharova, N; Tennikova, T; Urtti, A; Korzhikova-Vlakh, E. 2020. Pharmaceutics. 12: 39

Avoiding the Pitfalls of siRNA Delivery to the Retinal Pigment Epithelium with Physiologically Relevant Cell Models.

Ramsay, Eva; Raviña, Manuela; Sarkhel, Sanjay; Hehir, Sarah; Cameron, Neil R; Ilmarinen, Tanja; Skottman, Heli; Kjems, Jørgen; Urtti, Arto; Ruponen, Marika; Subrizi, Astrid. 2020. Pharmaceutics. 12: 667

Characterization, Stability, and in Vivo Efficacy Studies of Recombinant Human CNTF and Its Permeation Into the Neural Retina in Ex Vivo Organotypic Retinal Explant Culture Models

Itkonen, Jaakko; Annala, Ada; Tavakoli, Shirin; Arango-Gonzalez, Blanca; Ueffing, Marius; Toropainen, Elisa; Ruponen, Marika; Casteleijn, Marco G; Urtti, Arto. 2020. Pharmaceutics. 12: E611

Comprehensive Ocular and Systemic Pharmacokinetics of Brinzolamide in Rabbits After Intracameral, Topical, and Intravenous Administration

Naageshwaran, Vatsala; Ranta, Veli-Pekka; Gum, Glenwood; Bhoopathy, Siddhartha; Urtti, Arto; del Amo, Eva M. 2020. Journal of pharmaceutical sciences. 2021; 110: 529-535

Design and synthesis of lipid-mimetic cationic iridium complexes and their liposomal formulation for in vitro and in vivo application in luminescent bioimaging

Shakirova, Julia R; Sadeghi, Amir; Koblova, Alla A; Chelushkin, Pavel S; Toropainen, Elisa; Tavakoli, Shirin; Kontturi, Leena-Stiina; Lajunen, Tatu; Tunik, Sergey P; Urtti, Arto. 2020. Rsc advances. 10: 14431-14440

Diffusion and Protein Corona Formation of Lipid-Based Nanoparticles in the Vitreous Humor: Profiling and Pharmacokinetic Considerations

Tavakoli, Shirin; Kari, Otto Kalevi; Turunen, Tiina; Lajunen, Tatu; Schmitt, Mechthild; Lehtinen, Julia; Tasaka, Fumitaka; Parkkila, Petteri; Ndika, Joseph; Viitala, Tapani; Alenius, Harri; Urtti, Arto; Subrizi, Astrid. 2020. Molecular pharmaceutics. 2021; 18: 699-713

Extended Pharmacokinetic Model of the Intravitreal Injections of Macromolecules in Rabbits. Part 2: Parameter Estimation Based on Concentration Dynamics in the Vitreous, Retina, and Aqueous Humor

Lamminsalo, Marko; Karvinen, Timo; Subrizi, Astrid; Urtti, Arto; Ranta, Veli-Pekka. 2020. Pharmaceutical research. 37: 226

Hexosome engineering for targeting of regional lymph nodes

Helvig, Shen Y; Andersen, Helene; Antopolsky, Maxim; Airaksinen, Anu J; Urtti, Arto; Yaghmur, Anan; Moghimi, Seyed M. 2020. Materialia. 11: 100705

Intravitreal hydrogels for sustained release of therapeutic proteins

Ilochonwu, Blessing C; Urtti, Arto; Hennink, Wim E; Vermonden, Tina. 2020. Journal of controlled release. 326: 419-441

Light-Activated Liposomes Coated with Hyaluronic Acid as a Potential Drug Delivery System

Kari, Otto K; Tavakoli, Shirin; Parkkila, Petteri; Baan, Simone; Savolainen, Roosa; Ruoslahti, Teemu; Johansson, Niklas G; Ndika, Joseph; Alenius, Harri; Viitala, Tapani; Urtti, Arto; Lajunen, Tatu. 2020. Pharmaceutics. 12: 763

Microflow-Based Device for In Vitro and Ex Vivo Drug Permeability Studies

Hemmilä, Samu; Ruponen, Marika; Toropainen, Elisa; Tengvall-Unadike, Unni; Urtti, Arto; Kallio, Pasi. 2020. SLAS technology. 25: 455-462

Microscale Thermophoresis as a Screening Tool to Predict Melanin Binding of Drugs

Hellinen, Laura; Bahrpeyma, Sina; Rimpelä, Anna-Kaisa; Hagström, Marja; Reinisalo, Mika; Urtti, Arto. 2020. Pharmaceutics. 12: 554

Mitophagy in the Retinal Pigment Epithelium of Dry Age-Related Macular Degeneration Investigated in the NFE2L2/PGC-1α-/- Mouse Model

Sridevi Gurubaran, Iswariyaraja; Viiri, Johanna; Koskela, Ali; Hyttinen, Juha M; Paterno, Jussi; Kis, Gréta; Antal, Miklós; Urtti, Arto; Kauppinen, Anu; Felszeghy, Szabolcs; Kaarniranta, Kai. 2020. International journal of molecular sciences. 21: 1976

Ocular barriers to retinal delivery of intravitreal liposomes: Impact of vitreoretinal interface

Tavakoli, Shirin; Peynshaert, Karen; Lajunen, Tatu; Devoldere, Joke; Del Amo, Eva M; Ruponen, Marika; De Smedt, Stefaan C; Remaut, Katrien; Urtti, Arto. 2020. Journal of controlled release. 328: 952-961

Prodrug Approach for Posterior Eye Drug Delivery: Synthesis of Novel Ganciclovir Prodrugs and in Vitro Screening with Cassette Dosing

Heikkinen, Emma M; Ruponen, Marika; Jasper, Lisa-Marie; Leppänen, Jukka; Hellinen, Laura; Urtti, Arto; Auriola, Seppo; Rautio, Jarkko; Vellonen, Kati-Sisko. 2020. Molecular pharmaceutics. 17: 1945-1953

Release of functional dexamethasone by intracellular enzymes: A modular peptide-based strategy for ocular drug delivery

Bhattacharya, Madhushree; Sadeghi, Amir; Sarkhel, Sanjay; Hagström, Marja; Bahrpeyma, Sina; Toropainen, Elisa; Auriola, Seppo; Urtti, Arto. 2020. Journal of controlled release. 327: 584-594

The effect of prolyl oligopeptidase inhibitors on alpha-synuclein aggregation and autophagy cannot be predicted by their inhibitory efficacy

Kilpeläinen, Tommi P; Hellinen, Laura; Vrijdag, Johannes; Yan, Xu; Svarcbahs, Reinis; Vellonen, Kati-Sisko; Lambeir, Anne-Marie; Huttunen, Henri; Urtti, Arto; Wallen, Erik; Myöhänen, Timo. 2020. Biomedicine and pharmacotherapy. 128: 110253

Topical ocular pharmacokinetics and bioavailability for a cocktail of atenolol, timolol and betaxolol in rabbits

Fayyaz, Anam; Ranta, Veli-Pekka; Toropainen, Elisa; Vellonen, Kati-Sisko; Valtari, Annika; Puranen, Jooseppi; Ruponen, Marika; Gardner, Iain; Urtti, Arto; Jamei, Masoud; del Amo, Eva M.. 2020. European journal of pharmaceutical sciences. 155: 105553

Artificially cloaked viral nanovaccine for cancer immunotherapy

Fusciello, M; Fontana, F; Tähtinen, S; Capasso, C; Feola, S; Martins, B; Chiaro, J; Peltonen, K; Ylösmäki, L; Ylösmäki, E; Hamdan, F; Kari, OK; Ndika, J; Alenius, H; Urtti, A; Hirvonen, JT; Santos, HA; Cerullo, V. 2019. Nature communications. 10: 5747

CD44 aptamer mediated cargo delivery to lysosomes of retinal pigment epithelial cells to prevent age-related macular degeneration

Chandola, C; Casteleijn, MG; Chandola, UM; Gopalan, LN; Urtti, A; Neerathilingam, M. 2019. Biochemistry and biophysics reports. 18: 100642

Characterization of CDNF-Secreting ARPE-19 Cell Clones for Encapsulated Cell Therapy

Galli, E; Lindholm, P; Kontturi, LS; Saarma, M; Urtti, A; Yliperttula, M. 2019. Cell transplantation. 28: 412-424

Characterization of artificially re-pigmented ARPE-19 retinal pigment epithelial cell model

Hellinen, L; Hagström, M; Knuutila, H; Ruponen, M; Urtti, A; Reinisalo, M. 2019. Scientific reports. 9: 13761

Comment on "Topical Delivery of Avastin to the Posterior Segment of the Eye In Vivo Using Annexin A5-Associated Liposomes": Topical Liposomal Bevacizumab Results in Negligible Retinal Concentrations

Urtti, Arto. 2019. Small. 15: 1805199

Design principles of ocular drug delivery systems: importance of drug payload, release rate, and material properties

Subrizi, A; Amo, EMD; Korzhakov-Vlakh, V; Tennikova, T; Ruponen, M; Urtti, A. 2019. Drug discovery today. 24: 1446-1457

Distribution of Small Molecular Weight Drugs into the Porcine Lens: Studies on Imaging Mass Spectrometry, Partition Coefficients, and Implications in Ocular Pharmacokinetics

Heikkinen, EM; Auriola, S; Ranta, VP; Demarais, N; Grey, A; Del Amo, E; Toropainen, E; Vellonen, KS; Urtti, A; Ruponen, M. 2019. Molecular pharmaceutics. 16: 3968-3976

Electrical synapses interconnecting axons revealed in the optic nerve head - a novel model of gap junctions' involvement in optic nerve function

Smedowski, A; Akhtar, S; Liu, X; Pietrucha-Dutczak, M; Podracka, L; Toropainen, E; Alkanaan, A; Ruponen, M; Urtti, A; Varjosalo, M; Kaarniranta, K; Lewin-Kowalik, J. 2019. Acta ophthalmologica. [Epub ahead of print 10 Oct 2019]: 1-10

Electron dispersive X-ray spectroscopy and degradation properties of hyaluronic acid decorated microparticles

Serri, Carla; Frigione, Mariaenrica; Ruponen, Marika; Urtti, Arto; Borzacchiello, Assunta; Biondi, Marco; Mayol, Laura. 2019. Colloids and surfaces b: biointerfaces. 181: 896-901

Enhanced Delivery of 4-Thioureidoiminomethylpyridinium Perchlorate in Tuberculosis Models with IgG Functionalized Poly(Lactic Acid)-Based Particles

Churilov, Leonid; Korzhikov-Vlakh, Viktor; Sinitsyna, Ekaterina; Polyakov, Dmitry; Darashkevich, Oleg; Poida, Mikhail; Platonova, Galina; Vinogradiva, Tatiana; Utekhin, Vladimir; Zabolotnykh, Natalia; Zinserling, Vsevolod; Yablonsky, Peter; Urtti, Arto; Tennikova, Tatiana. 2019. Pharmaceutics. 11: 2

Establishment of an In Vitro-In Vivo Correlation for Melanin Binding and the Extension of the Ocular Half-Life of Small-Molecule Drugs

Jakubiak, Paulina; Cantrill, Carina; Urtti, Arto; Alvarez-Sanchez, Ruben. 2019. Molecular pharmaceutics. 16: 4890-4901

Exploring Light-Sensitive Nanocarriers for Simultaneous Triggered Antibiotic Release and Disruption of Biofilms Upon Generation of Laser-Induced Vapor Nanobubbles

Teirlinck, E; Barras, A; Liu, J; Fraire, JC; Lajunen, T; Xiong, R; Forier, K; Li, C; Urtti, A; Boukherroub, R; Szunerits, S; De Smedt, SC; Coenye, T; Braeckmans, K. 2019. Pharmaceutics. 11: 201

Exploring the mucoadhesive behavior of sucrose acetate isobutyrate: a novel excipient for oral delivery of biopharmaceuticals

Harloff-Helleberg, S; Fliervoet, LAL; Fanø, M; Schmitt, M; Antopolski, M; Urtti, A; Nielsen, HM. 2019. Drug delivery. 26: 532-541

Highly Hydrophilic 1,3-Oxazol-5-yl Benzenesulfonamide Inhi bitors of Carbonic Anhydrase II for Reduction of Glaucoma-Related Intraocular Pressure

Kalinin, Stanislav; Valtari, Annika; Ruponen, Marika; Toropainen, Elisa; Kovalenko, Alexander; Nocentini, Alessio; Gureev, Maxim; Dar'in, Dmitry; Urtti, Arto; Supuran, Claudiu T; Krasavin, Mikhail. 2019. Bioorganic and medicinal chemistry. 27: 115086

ISOPT Clinical Hot Topic Panel Discussion on Ocular Drug Delivery

Kompella, UB; Domb, A; Urtti, A; Jayagopal, A; Wilson, CG; Tang-Liu, D. 2019. Journal of ocular pharmacology and therapeutics. 35: 457-465

In situ analysis of liposome hard and soft protein corona structure and composition in a single label-free workflow

Kari, OK; Ndika, J; Parkkila, P; Louna, A; Lajunen, T; Puustinen, A; Viitala, T; Alenius, H; Urtti, A. 2019. Nanoscale. 2020; 12: 1728-1741

Influence of Melanin Characteristics on Drug Binding Properties

Jakubiak, Paulina; Lack, Flavio; Thun, Jurgen; Urtti, Arto; Alvarez-Sanchez, Ruben. 2019. Molecular pharmaceutics. 16: 2549-2556

Intravitreal Pharmacokinetics in Mice: SPECT/CT Imaging and Scaling to Rabbits and Humans

Schmitt, Mechthild; Hippeläinen, Eero; Raviña, Manuela; Arango-Gonzalez, Blanca; Antopolsky, Maxim; Vellonen, Kati-Sisko; Airaksinen, Anu J; Urtti, Arto. 2019. Molecular pharmaceutics. 16: 4399-4404

Light-Triggered Cellular Delivery of Oligonucleotides

Kontturi, LS; van den Dikkenberg, J; Urtti, A; Hennink, WE; Mastrobattista, E. 2019. Pharmaceutics. 11: 90

Modified cells as potential ocular drug delivery systems

Tennikova, Tatiana; Urtti, Arto. 2019. Drug discovery today. 24: 1621-1626

Ocular Intracameral Pharmacokinetics for a Cocktail of Timolol, Betaxolol, and Atenolol in Rabbits

Fayyaz, A; Ranta, VP; Toropainen, E; Vellonen, KS; Ricci, GD; Reinisalo, M; Heikkinen, EM; Gardner, I; Urtti, A; Jamei, M; del Amo, EM. 2019. Molecular pharmaceutics. 12: e007045

Pharmacokinetic Simulations of Intravitreal Biologicals: Aspects of Drug Delivery to the Posterior and Anterior Segments

Rimpelä, AK; Kiiski, I; Deng, F; Kidron, H; Urtti, A. 2019. Pharmaceutics. 11: 9

Polysaccharides in Ocular Drug Delivery

Dubashynskaya, N; Poshina, D; Raik, S; Urtti, A; Skorik, YA. 2019. Pharmaceutics. 12: 22

Quantitative Protein Expression in the Human Retinal Pigment Epithelium: Comparison Between Apical and Basolateral Plasma Membranes With Emphasis on Transporters

Hellinen, Laura; Sato, Kazuki; Reinisalo, Mika; Kidron, Heidi; Rilla, Kirsi; Tachikawa, Masanori; Uchida, Yasuo; Terasaki, Tetsuya; Urtti, Arto. 2019. Investigative ophthalmology and visual science. 60: 5022-5034

Retinal Pigment Epithelial Cell Line with Fast Differentiation and Improved Barrier Properties

Hellinen, L; Pirskanen, L; Tengvall-Unadike, U; Urtti, A; Reinisalo, M. 2019. Pharmaceutics. 11: 412

Retinal bioavailability of liposomal minocycline after sub-conjunctival administration is low

Urtti, Arto. 2019. Nanomedicine: nanotechnology biology and medicine. 18: 427

Role of retinal pigment epithelium permeability in drug transfer between posterior eye segment and systemic blood circulation

Ramsay, E; Hagström, M; Vellonen, KS; Boman, S; Toropainen, E; Del Amo, EM; Kidron, H; Urtti, A; Ruponen, M. 2019. European journal of pharmaceutics and biopharmaceutics. 143: 18-23

Accelerated pharmaceutical protein development with integrated cell free expression, purification, and bioconjugation

Richardson, Dominique; Itkonen, Jaakko; Nievas, Julia; Urtti, Arto; Casteleijn, Marco G. 2018. Scientific reports. 8: 11967

Cisplatin Encapsulation Generates Morphologically Different Multicompartments in the Internal Nanostructures of Nonlamellar Liquid-Crystalline Self-Assemblies

Mat Azmi, Intan Diana; Østergaard, Jesper; Stürup, Stefan; Gammelgaard, Bente; Urtti, Arto; Moghimi, Seyed Moein; Yaghmur, Anan. 2018. Langmuir. 34: 6570-6581

Corneal and conjunctival drug permeability : systematic comparison and pharmacokinetic impact in the eye

Ramsay, Eva; del Amo, Eva M; Toropainen, Elisa; Tengvall-Unadike, Unni; Ranta, Veli-Pekka; Urtti, Arto; Ruponen, Marika. 2018. European journal of pharmaceutical sciences. 119: 83-89

Esterase activity in porcine and albino rabbit ocular tissues

Heikkinen, Emma M; del Amo, Eva M; Ranta, Veli-Pekka; Urtti, Arto; Vellonen, Kati-Sisko; Ruponen, Marika. 2018. European journal of pharmaceutical sciences. 123: 106-110

Expression, activity and pharmacokinetic impact of ocular transporters

Vellonen, Kati-Sisko; Hellinen, Laura; Mannermaa, Eliisa; Ruponen, Marika; Urtti, Arto; Kidron, Heidi. 2018. Advanced drug delivery reviews. 126: 3-22

Extended Pharmacokinetic Model of the Rabbit Eye for Intravitreal and Intracameral Injections of Macromolecules: Quantitative Analysis of Anterior and Posterior Elimination Pathways

Lamminsalo, Marko; Taskinen, Ella; Karvinen, Timo; Subrizi, Astrid; Murtomäki, Lasse; Urtti, Arto: Ranta, Veli-Pekka. 2018. Pharmaceutical research. 35: 153

Iho lääkeaineiden antoreittinä

Urtti, Arto; Ruponen, Marika; Pajula, Katja; Vellonen, Kati-Sisko. Teoksessa: Ruponen, Marika; Urtti, Arto; Pajula, Katja; Honkakoski, Paavo(toim.) , 2018. Biofarmasian perusteet. s. 135-148. Farmasian opiskelijayhdidtys Fortis ry

Implications of melanin binding in ocular drug delivery

Rimpelä, Anna-Kaisa; Reinisalo, Mika; Hellinen, Laura; Grazhdankin, Evgeni; Kidron, Heidi; Urtti Arto; del Amo, Eva M. 2018. Advanced drug delivery reviews. 126: 23-43

Loss of NRF-2 and PGC-1[alpha] genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration

Felszeghy, S; Viiri, J; Paterno, JJ; Hyttinen, JMT; Koskela, A; Chen, M; Leinonen, H; Tanila, H; Kivinen, N; Koistinen, A; Toropainen, E; Amadio, M; Smedowski, A; Reinisalo, M; Winiarczyk, M; Mackiewicz, J; Mutikainen, M; Ruotsalainen, AK; Kettunen, M; Jokivarsi, K; et al [Incl Kaarniranta, K; Kauppinen, A; Kinnunen, K; Levonen, A-L; Salminen, A; Tavi, P-P; Urtti, A]. 2018. Redox biology. 2019; 20: 1-12

Lääkkeenanto laskimoon, lihakseen ja ihan alle

Urtti, Arto; Ruponen, Marika. Teoksessa: Ruponen, Marika; Urtti, Arto; Pajula, Katja; Honkakoski, Paavo(toim.) , 2018. Biofarmasian perusteet. s. 45-55. Farmasian opiskelijayhdidtys Fortis ry

Melanin targeting for intracellular drug delivery: Quantification of bound and free drug in retinal pigment epithelial cells

Rimpelä, Anna-Kaisa; Hagström, Marja; Kidron, Heidi; Urtti, Arto. 2018. Journal of controlled release. 283: 261-268

Preface

Bunt, Craig; Urtti, Arto; Thrimawithana, Thilini. 2018. Advanced drug delivery reviews. 126: 1-2

Silmän biofarmasia [Ocular biopharmacy]

Urtti, Arto; Ruponen, Marika; Pajula, Katja; del Amo, Eva. Teoksessa: Ruponen, Marika; Urtti, Arto; Pajula, Katja; Honkakoski, Paavo(toim.) , 2018. Biofarmasian perusteet [Basics of Biopharmacy]. s. 149-163. Farmasian opiskelijayhdidtys Fortis ry

Spin coated chitin films for biosensors and its analysis are dependent on chitin-surface interactions

Casteleijn, Marco G; Richardson, Dominique; Parkkila, Petteri; Granqvist, Niko; Urtti, Arto; Viitala, Tapani. 2018. Colloids and surfaces a: physicochemical and engineering aspects. 539: 261-272

Suun kautta otettujen lääkeaineiden imeytyminen

Urtti, Arto; Ruponen, Marika; Pajula, Katja; Yliperttula, Marjo; Honkakoski, Paavo; Ranta, Veli-Pekka; Kidron, Heidi; Vellonen, Kati-Sisko. Teoksessa: Ruponen, Marika; Urtti, Arto; Pajula, Katja; Honkakoski, Paavo(toim.) , 2018. Biofarmasian perusteet. s. 57-96. Farmasian opiskelijayhdidtys Fortis ry

The effect of light sensitizer localization on the stability of indocyanine green liposomes

Lajunen, T; Nurmi, R; Wilbie, D; Ruoslahti, T; Johansson, NG; Korhonen, O; Rog, T; Bunker, A; Ruponen, M; Urtti, A. 2018. Journal of controlled release. 284: 213-223

Understanding Molecular Drivers of Melanin Binding To Support Rational Design of Small Molecule Ophthalmic Drugs

Jakubiak, Paulina; Reutlinger, Michael; Mattei, Patrizio; Schuler, Franz; Urtti, Arto; Alvarez-Sanchez, Ruben. 2018. Journal of medicinal chemistry. 61: 10106-10115

Differentially cleaving peptides as a strategy for controlled drug release in human retinal pigment epithelial cells

Bhattacharya M, Sarkhel S, Peltoniemi J, Broadbridge R, Tuomainen M, Auriola S, Urtti A. 2017. Journal of controlled release. 251: 37-48

Hyaluronic Acid Graft Copolymers with Cleavable Arms as Potential Intravitreal Drug Delivery Vehicles

Borke T, Najberg M, Ilina P, Bhattacharya M, Urtti A, Tenhu H, Hietala S. 2017. Macromolecular bioscience. 2018; 18: 1700200

Impact of Chemical Structure on Conjunctival Drug Permeability: Adopting Porcine Conjunctiva and Cassette Dosing for Construction of In Silico Model

Ramsay E, Ruponen M, Picardat T, Tengvall U, Tuomainen M, Auriola S, Toropainen E, Urtti A, del Amo EM. 2017. Journal of pharmaceutical sciences. 106: 2463-2471

Increased intraocular pressure alters the cellular distribution of HuR protein in retinal ganglion cells : a possible sign of endogenous neuroprotection failure

Smedowski A, Liu X, Podracka L, Akhtar S, Trzeciecka A, Pietrucha-Dutczak M, Lewin-Kowalik J, Urtti A, Ruponen M, Kaarniranta K, Varjosalo M, Amadio M. 2017. Biochimica et biophysica acta: molecular basis of disease. 2018; 1864: 296-306

Inner Blood-Retinal Barrier Dominantly Expresses Breast Cancer Resistance Protein: Comparative Quantitative Targeted Absolute Proteomics Study of CNS Barriers in Pig

Zhang Z, Uchida Y, Hirano S, Ando D, Kubo Y, Auriola S, Akanuma S-I, Hosoya K-I, Urtti A, Terasaki T, Tachikawa M. 2017. Molecular pharmaceutics. 14: 3729-3738

LC-MS/MS Based Quantitation of ABC and SLC Transporter Proteins in Plasma Membranes of Cultured Primary Human Retinal Pigment Epithelium Cells and Immortalized ARPE19 Cell Line

Pelkonen L, Sato K, Reinisalo M, Kidron H, Tachikawa M, Watanabe M, Uchida Y, Urtti A, Terasaki T. 2017. Molecular pharmaceutics. 14: 605-613

Melanin binding study of clinical drugs with cassette dosing and rapid equilibrium dialysis inserts

Pelkonen L, Tengvall-Unadike U, Ruponen M, Kidron H, del Amo EM, Reinisalo M, Urtti A. 2017. European journal of pharmaceutical sciences. 109: 162-168

Nanofibrillar cellulose-alginate hydrogel coated surgical sutures as cell-carrier systems

Laurén P, Somersalo P, Pitkänen I, Lou YR, Urtti A, Partanen J, Seppälä J, Madetoja M, Laaksonen T, Mäkitie A, Yliperttula M. 2017. PLoS ONE. 12: e0183487

Pharmacokinetic aspects of retinal drug delivery

del Amo Eva M, Rimpelä Anna-Kaisa, Heikkinen Emma, Kari Otto K, Ramsay Eva, Lajunen Tatu, Schmitt Mechthild, Pelkonen Laura, Bhattacharya Madhushree, Richardson Dominique, Subrizi Astrid, Turunen Tiina, Reinisalo Mika, Itkonen Jaakko, Toropainen Elisa, Casteleijn Marco, Kidron Heidi, Antopolsky Maxim, Vellonen Kati-Sisko, Ruponen Marika, et al.. 2017. Progress in retinal and eye research. 57: 134-185

Time-Resolved Fluorescence Spectroscopy Reveals Fine Structure and Dynamics of Poly(l-lysine) and Polyethylenimine Based DNA Polyplexes

Lisitsyna ES, Ketola TM, Morin-Picardat E, Liang H, Hanzlíková M, Urtti A, Yliperttula M, Vuorimaa-Laukkanen E. 2017. Journal of physical chemistry b. 121: 10782-10792

Application of aptamers in diagnostics, drug-delivery and imaging

Chandola Chetan, Kalme Sheetal, Casteleijn Marco G, Urtti Arto, Neerathilingam Muniasamy. 2016. Journal of biosciences. 41: 535-561

Drug Distribution to Retinal Pigment Epithelium: Studies on Melanin Binding, Cellular Kinetics, and Single Photon Emission Computed Tomography/Computed Tomography Imaging

Rimpelä Anna-Kaisa, Schmitt Mechthild, Latonen Satu, Hagström Marja, Antopolsky Maxim, Manzanares José A, Kidron Heidi, Urtti Arto. 2016. Molecular pharmaceutics. 13: 2977-2986

General Pharmacokinetic Model for Topically Administered Ocular Drug Dosage Forms

Deng Feng, Ranta Veli-Pekka, Kidron Heidi, Urtti Arto. 2016. Pharmaceutical research. 33: 2680-2690

HDAC inhibition in the cpfl1 mouse protects degenerating cone photoreceptors in vivo

Trifunovic Dragana, Arango-Gonzalez Blanca, Comitato Antonella, Barth Melanie, Del Amo Eva M, Kulkarni Manoj, Sahaboglu Ayse, Hauck Stefanie M, Urtti Arto, Arsenijevic Yvan, Ueffing Marius, Marigo Valeria, Paquet-Durand Francois. 2016. Human molecular genetics. 25: 4462-4472

Hepatic differentiation of human pluripotent stem cells on human liver progenitor HepaRG-derived acellular matrix

Kanninen Liisa K, Porola Pauliina, Niklander Johanna, Malinen Melina M, Corlu Anne, Guguen-Guillouzo Christiane, Urtti Arto, Yliperttula Marjo L, Lou Yan-Ru. 2016. Experimental cell research. 341: 207-217

Human corneal cell culture models for drug toxicity studies

Rönkkö Seppo, Vellonen Kati-Sisko, Järvinen Kristiina, Toropainen Elisa, Urtti Arto. 2016. Drug delivery and translational research. 6: 660-675

Increased circulating concentrations of mesencephalic astrocyte-derived neurotrophic factor in children with type 1 diabetes

Galli Emilia, Härkönen Taina, Sainio Markus T, Ustav Mart, Toots Urve, Urtti Arto, Yliperttula Marjo, Lindahl Maria, Knip Mikael, Saarma Mart, Lindholm Päivi. 2016. Scientific reports. 6: 29058

Indocyanine Green-Loaded Liposomes for Light-Triggered Drug Release

Lajunen Tatu, Kontturi Leena-Stiina, Viitala Lauri, Manna Moutusi, Cramariuc Oana, Róg Tomasz, Bunker Alex, Laaksonen Timo, Viitala Tapani, Murtomäki Lasse, Urtti Arto. 2016. Molecular pharmaceutics. 13: 2095-2107

Interpretation of Ocular Melanin Drug Binding Assays. Alternatives to the Model of Multiple Classes of Independent Sites

Manzanares José A, Rimpelä Anna-Kaisa, Urtti Arto. 2016. Molecular pharmaceutics. 13: 1251-1257

Intracellular PK/PD Relationships of Free and Liposomal Doxorubicin: Quantitative Analyses and PK/PD Modeling

Soininen Suvi K, Vellonen Kati-Sisko, Heikkinen Aki T, Auriola Seppo, Ranta Veli-Pekka, Urtti Arto, Ruponen Marika. 2016. Molecular pharmaceutics. 13: 1358-1365

Isolation of Intact and Functional Melanosomes from the Retinal Pigment Epithelium

Pelkonen Laura, Reinisalo Mika, Morin-Picardat Emmanuelle, Kidron Heidi, Urtti Arto. 2016. PLoS ONE. 11: e0160352

Laminin-511 and laminin-521-based matrices for efficient hepatic specification of human pluripotent stem cells

Kanninen Liisa K, Harjumäki Riina, Peltoniemi Pasi, Bogacheva Mariia S, Salmi Tuuli, Porola Pauliina, Niklander Johanna, Smutný Tomás, Urtti Arto, Yliperttula Marjo L, Lou Yan-Ru. 2016. Biomaterials. 103: 86-100

Light activated liposomes: Functionality and prospects in ocular drug delivery

Lajunen Tatu, Nurmi Riikka, Kontturi Leena, Viitala Lauri, Yliperttula Marjo, Murtomäki Lasse, Urtti Arto. 2016. Journal of controlled release. 244: 157-166

Multi-parametric surface plasmon resonance platform for studying liposome-serum interactions and protein corona formation

Kari Otto K, Rojalin Tatu, Salmaso Stefano, Barattin Michela, Jarva Hanna, Meri Seppo, Yliperttula Marjo, Viitala Tapani, Urtti Arto. 2016. Drug delivery and translational research. 2017; 7: 228-240

Olaparib significantly delays photoreceptor loss in a model for hereditary retinal degeneration

Sahaboglu Ayse, Barth Melanie, Secer Enver, del Amo Eva M, Urtti Arto, Arsenijevic Yvan, Zrenner Eberhart, Paquet-Durand Francois. 2016. Scientific reports. 6: 39537

Oncolytic adenoviruses coated with MHC-I tumor epitopes increase the antitumor immunity and efficacy against melanoma

Capasso Cristian, Hirvinen Mari, Garofalo Mariangela, Romaniuk Dmitrii, Kuryk Lukasz, Sarvela Teea, Vitale Andrea, Antopolsky Maxim, Magarkar Aniket, Viitala Tapani, Suutari Teemu, Bunker Alex, Yliperttula Marjo, Urtti Arto, Cerullo Vincenzo. 2016. Oncoimmunology. 5: e1105429

Photothermally Triggered Lipid Bilayer Phase Transition and Drug Release from Gold Nanorod and Indocyanine Green Encapsulated Liposomes

Viitala Lauri, Pajari Saija, Lajunen Tatu, Kontturi Leena-Stiina, Laaksonen Timo, Kuosmanen Päivi, Viitala Tapani, Urtti Arto, Murtomäki Lasse. 2016. Langmuir. 32: 4554-4563

Predictive Modeling of Ocular Pharmacokinetics and Adverse Effects

Ghemtio Leo, Xhaard Henri, Urtti Arto, Kidron Heidi. 2016. Current pharmaceutical design. 22: 6928-6934

Regulation of Human Pluripotent Stem Cell-Derived Hepatic Cell Phenotype by Three-Dimensional Hydrogel Models

Toivonen Sanna, Malinen Melina M, Küblbeck Jenni, Petsalo Aleksanteri, Urtti Arto, Honkakoski Paavo, Otonkoski Timo. 2016. Tissue engineering. 22: 971-984

Cellular and Nuclear Concentrations and Cytotoxicity of Anticancer Drug Doxorubicin and its Liposomal Formulations in Two Cancer Cell Types

Soininen Suvi K, Vellonen Kati-Sisko, Koivisto Heta, Urtti Arto, Ruponen Marika. 2015. Publications of the University of Eastern Finland. Reports and studies in health sciences

Exploring the structure-activity relationships of ABCC2 modulators using a screening approach

Wissel Gloria, Kudryavtsev Pavel, Ghemtio Leo, Tammela Päivi, Wipf Peter, Yliperttula Marjo, Finel Moshe, Urtti Arto, Kidron Heidi, Xhaard Henri. 2015. Bioorganic and medicinal chemistry. 23: 3513-3525

Intravitreal clearance and volume of distribution of compounds in rabbits: In silico prediction and pharmacokinetic simulations for drug development

Del Amo Eva M, Vellonen Kati-Sisko, Kidron Heidi, Urtti Arto. 2015. European journal of pharmaceutics and biopharmaceutics. 95: 215-226

Light induced cytosolic drug delivery from liposomes with gold nanoparticles

Lajunen Tatu, Viitala Lauri, Kontturi Leena-Stiina, Laaksonen Timo, Liang Huamin, Vuorimaa-Laukkanen Elina, Viitala Tapani, Le Guével Xavier, Yliperttula Marjo, Murtomäki Lasse, Urtti Arto. 2015. Journal of controlled release. 203: 85-98

Modulatory effect of human plasma on the internal nanostructure and size characteristics of liquid-crystalline nanocarriers

Mat Azmi Intan D, Wu Linping, Wibroe Peter P, Nilsson Christa, Østergaard Jesper, Stürup Stefan, Gammelgaard Bente, Urtti Arto, Moghimi Seyed M, Yaghmur Anan. 2015. Langmuir. 31: 5042-5049

Novel biodegradable polyesteramide microspheres for controlled drug delivery in Ophthalmology

Andrés-Guerrero Vanessa, Zong Mengmeng, Ramsay Eva, Rojas Blanca, Sarkhel Sanjay, Gallego Beatriz, de Hoz Rosa, Ramírez Ana I, Salazar Juan J, Triviño Alberto, Ramírez José M, Del Amo Eva M, Cameron Neil, de-Las-Heras Beatriz, Urtti Arto, Mihov George, Dias Aylvin, Herrero-Vanrell Rocío. 2015. Journal of controlled release. 211: 105-117

Prediction of ocular drug distribution from systemic blood circulation

Vellonen Kati-Sisko, Soini Esa-Matti, del Amo Eva M, Urtti Arto. 2015. Molecular pharmaceutics. 13 (2016): 2906-2911

Rabbit as an animal model for intravitreal pharmacokinetics: Clinical predictability and quality of the published data

Del Amo Eva M, Urtti Arto. 2015. Experimental eye research. 137: 111-124

Undefined role of mucus as a barrier in ocular drug delivery

Ruponen Marika, Urtti Arto. 2015. European journal of pharmaceutics and biopharmaceutics. 96: 442-446

A critical assessment of in vitro tissue models for ADME and drug delivery

Vellonen Kati-Sisko, Malinen Melina, Mannermaa Eliisa, Subrizi Astrid, Toropainen Elisa, Lou Yan-Ru, Kidron Heidi, Yliperttula Marjo, Urtti Arto. 2014. Journal of controlled release. 190: 94-114

An injectable, in situ forming type II collagen/hyaluronic acid hydrogel vehicle for chondrocyte delivery in cartilage tissue engineering

Kontturi Leena-Stiina, Järvinen Elina, Muhonen Virpi, Collin Estelle C, Pandit Abhay S, Kiviranta Ilkka, Yliperttula Marjo, Urtti Arto. 2014. Drug delivery and translational research. 4: 149-158

Codon optimization and factorial screening for enhanced soluble expression of human ciliary neurotrophic factor in Escherichia coli

Itkonen Jaakko M, Urtti Arto, Bird Louise E, Sarkhel Sanjay. 2014. Bmc biotechnology. 14: 92

Differentiation of liver progenitor cell line to functional organotypic cultures in 3D nanofibrillar cellulose and hyaluronan-gelatin hydrogels

Malinen Melina M, Kanninen Liisa K, Corlu Anne, Isoniemi Helena M, Lou Yan-Ru, Yliperttula Marjo L, Urtti Arto O. 2014. Biomaterials. 35: 5110-5121

Encapsulated cells for long-term secretion of soluble VEGF receptor 1: material optimization and simulation of ocular drug response

Kontturi Leena-Stiina, Collin Estelle C, Murtomäki Lasse, Pandit Abhay S, Yliperttula Marjo, Urtti Arto. 2014. European journal of pharmaceutics and biopharmaceutics. 2015; 95: 387-397

Formulation and Stability of Cytokine Therapeutics

Lipiäinen Tiina, Peltoniemi Marikki, Sarkhel Sanjay, Yrjönen Teijo, Vuorela Heikki, Urtti Arto, Juppo Anne. 2014. Journal of pharmaceutical sciences. 2015; 104: 307-326

High-throughput in vitro drug release and pharmacokinetic simulation as a tool for drug delivery system development: Application to intravitreal ocular administration

Sarkhel Sanjay, Ramsay Eva, Kontturi Leena-Stiina, Peltoniemi Jonne, Urtti Arto. 2014. International journal of pharmaceutics. 477: 469-475

Naphthoquinones and Anthraquinones: Chemical, Analytical, and Biological Overview

El-Najjar Nahed, Gali-Muhtasib Hala, Vuorela Pia, Urtti Arto, Vuorela Heikki. Teoksessa: Meyers, R.A. (toim.)(toim.) , 2014. Encyclopedia of Analytical Chemistry. s. 1-16. John Wiley & Sons

Oxidative Stress Protection by Exogenous Delivery of rhHsp70 Chaperone to the Retinal Pigment Epithelium (RPE), a Possible Therapeutic Strategy Against RPE Degeneration

Subrizi Astrid, Toropainen Elisa, Ramsay Eva, Airaksinen Anu J, Kaarniranta Kai, Urtti Arto. 2014. Pharmaceutical research. 2015; 32: 211-221

PEGylation of phytantriol-based lyotropic liquid crystalline particles - the effect of lipid composition, PEG chain length, and temperature on the internal nanostructure

Nilsson Christa, Østergaard Jesper, Weng Larsen Susan, Larsen Claus, Urtti Arto, Yaghmur Anan. 2014. Langmuir. 30: 6398-6407

Pharmacokinetic simulations to explore dissolution criteria of BCS I and III biowaivers with and without MDR-1 efflux transporter

Kortejärvi H, Malkki J, Shawahna R, Scherrmann JM, Urtti A, Yliperttula M. 2014. European journal of pharmaceutical sciences. 61: 18-26

Poor Cellular Internalization of Caelyx® Limits its Toxic Effect Compared with Free Doxorubicin and pH-sensitive Liposomes Encapsulating Doxorubicin

Soininen Suvi K, Koivisto Heta, Vellonen Kati-Sisko, Urtti Arto, Ruponen Marika. 2014. -

Quantitative Analysis of Intracellular Pharmacokinetics of Doxorubicin and its Liposomal Formulations and A Computational Model of the Intracellular PK/PD Relationship

Soininen Suvi K, Välitalo Pyry, Koivisto Heta, Heikkinen Aki, Ranta Veli-Pekka, Vellonen Kati-Sisko, Urtti Arto, Ruponen Marika. 2014. Publications of the University of Eastern Finland. Reports and studies in health sciences

Technetium-99m-labeled nanofibrillar cellulose hydrogel for in vivo drug release

Laurén Patrick, Lou Yan-Ru, Raki Mari, Urtti Arto, Bergström Kim, Yliperttula Marjo. 2014. European journal of pharmaceutical sciences. 65: 79-88

The use of nanofibrillar cellulose hydrogel as a flexible three-dimensional model to culture human pluripotent stem cells

Lou Yan-Ru, Kanninen Liisa, Kuisma Tytti, Niklander Johanna, Noon Luke A, Burks Dedorah, Urtti Arto, Yliperttula Marjo. 2014. Stem cells and development. 23: 380-392

Topical drug delivery to retinal pigment epithelium with microfluidizer produced small liposomes

Lajunen T, Hisazumi K, Kanazawa T, Okada H, Seta Y, Yliperttula M, Urtti A, Takashima Y. 2014. European journal of pharmaceutical sciences. 62: 23-32

Xeno-free chondrogenesis of bone marrow mesenchymal stromal cells: towards clinical-grade chondrocyte production

Skog Maria, Muhonen Virpi, Nystedt Johanna, Narcisi Roberto, Kontturi Leena-Stiina, Urtti Arto, Korhonen Matti, van Osch Gerjo J, Kiviranta Ilkka. 2014. Cytotechnology. 2015; 67: 905-919

Challenges of using in vitro data for modeling p-glycoprotein efflux in the blood-brain barrier

Sjöstedt Noora, Kortejärvi Hanna, Kidron Heidi, Vellonen Kati-Sisko, Urtti Arto, Yliperttula Marjo. 2013. Pharmaceutical research. 2014:31: 1-19

Tutkijakoulutuksen muutoksia

Urtti Arto, Männistö Pekka T, Honkakoski Paavo. Teoksessa: Ahonen R, Laitinen K, Lapinjoki S, Mensalo P, Ranta V-P, Ylikangas H (toim).(toim.) , 2013. Muutosten vuosikymmen : Itä-Suomen yliopiston farmasian laitos 40 vuotta. s. 58-59.

Corneal epithelium as a platform for secretion of transgene products after transfection with liposomal gene eyedrops

Toropainen E, Hornof M, Kaarniranta K, Johansson P, Urtti A. 2007. Journal of gene medicine. 9: 208-216

Computational prediction of oral drug absorption based on absorption rate constants in humans

Linnankoski J, Mäkelä JM, Ranta V-P, Urtti A, Yliperttula M. 2006. Journal of medicinal chemistry. 49: 3674-3681

Epidermal cell culture model with tight stratum corneum as a tool for dermal gene delivery studies

Paasonen L, Korhonen M, Yliperttula M, Urtti A. 2006. International journal of pharmaceutics. 307: 188-193

Freeze-drying of cationic polymer DNA complexes enables their long-term storage and reverse transfection of post-mitotic cells

Reinisalo M, Urtti A, Honkakoski P. 2006. Journal of controlled release. 110: 437-443

Microemulsions in topical drug delivery

Pappinen S, Urtti A. Teoksessa: Smith EW, Maibach HI(toim.) , 2006. Percutaneous Penetration Enhancers. 2nd ed.. s. 109-116. CRC Press, Taylor & Francis Group

Cell culture models of the ocular barriers

Hornof M, Toropainen E, Urtti A. 2005. European journal of pharmaceutics and biopharmaceutics. 60: 207-225

Long-lasting secretion of transgene product from differentiated and filter-grown retinal pigment epithelial cells after nonviral gene transfer

Mannermaa E, Rönkkö S, Ruponen M, Reinisalo M, Urtti A. 2005. Current eye research. 30: 345-353

Nonviral gene delivery methods in cardiovascular diseases

Ruponen M, Hyvönen Z, Urtti A, Ylä-Herttuala S. Teoksessa: Fennell JP, Baker AH(toim.) , 2005. Hypertension. Methods and Protocols. s. 315-328. Humana Press

Permeability of retinal pigment epithelium: Effects of permeant molecular weight and lipophilicity

Pitkänen L, Ranta V-P, Moilanen H, Urtti A. 2005. Investigative ophthalmology and visual science. 46: 641-646

Rat epidermal keratinocyte organotypic culture (ROC) as a model for chemically induced skin irritation testing

Pappinen S, Pasonen-Seppänen S, Suhonen M, Tammi R, Urtti A. 2005. Toxicology and applied pharmacology. 208: 233-241

Surface plasmon resonance spectroscopy as a tool to study polyplex-glycoaminoglycan interactions

Dubruel P, Urtti A, Schacht E. 2005. Macromolecular rapid communications. 26: 992-997

The role of cell cycle on polyplex-mediated gene transfer into a retinal pigment epithelial cell line

Männistö M, Rönkkö S, Mättö M, Honkakoski P, Hyttinen M, Pelkonen J, Urtti A. 2005. Journal of gene medicine. 7: 466-476

Cell-surface glycosaminoglycans inhibit cation-mediated gene transfer

Ruponen M, Honkakoski P, Tammi M, Urtti A. 2004. Journal of gene medicine. 6: 405-414

Determination of the degree of substitution of acetylated starch by hydrolysis, 1H NMR and TGA/IR

Elomaa M, Asplund T, Soininen P, Laatikainen R, Peltonen S, Hyvärinen S, Urtti A. 2004. Carbohydrate polymers. : 261-267

Dioleoyl phosphatidylethanolamine and PEG-lipid conjugates modify DNA delivery mediated by 1,4-dihydropyridine amphiphiles

Hyvönen Z, Rönkkö S, Toppinen M-R, Jääskeläinen I, Plotniece A, Urtti A. 2004. Journal of controlled release. 99: 177-190

Drug permeation in biomembranes in vitro and in silico prediction and influence of physicochemical properties

Mälkiä A, Murtomäki L, Urtti A, Kontturi K. 2004. European journal of pharmaceutical sciences. 23: 13-47

Effect of cell-surface glycosaminoglycans on cationic carrier combined with low-MW PEI-mediated gene transfection

Lampela P, Soininen P, Puttonen KA, Ruponen M, Urtti A, Männistö PT, Raasmaja A. 2004. International journal of pharmaceutics. 284: 43-52

Electrochemical and calorimetric study of oligonucleotide complexation with cetylpyridinium chloride

Hakkarainen S, Kontturi A-K, Kontturi K, Urtti A. 2004. European journal of pharmaceutical sciences. 23: 371-377

Evaluation of novel starch acetate-diltiazem controlled release tablets in healthy human volunteers

Korhonen O, Kanerva H, Vidgren M, Urtti A, Ketolainen J. 2004. Journal of controlled release. 95: 515-520

Neural retina limits the nonviral gene transfer to retinal pigment epithelium in an vitro bovine eye model

Pitkänen L, Pelkonen J, Ruponen M, Rönkkö S, Urtti A. 2004. AAPS journal. 6: 1-9

Requirements for delivery of active antisense oligonucleotides into cells with lipid carriers

Jääskeläinen I, Lappalainen K, Honkakoski P, Urtti A. 2004. Methods in enzymology. 387: 210-230

Starch acetate microparticles for drug delivery into retinal pigment epithelium - in vitro study

Tuovinen L, Ruhanen E, Kinnarinen T, Rönkkö S, Pelkonen J, Urtti A, Peltonen S, Järvinen K. 2004. Journal of controlled release. 98: 407-413

Substrates and inhibitors of efflux proteins interfere with the MTT assay in cells and may lead to underestimation of drug toxicity

Vellonen K-S, Honkakoski P, Urtti A. 2004. European journal of pharmaceutical sciences. 23: 181-188

Synergism in gene delivery by small PEIs and three different nonviral vectors

Lampela P, Soininen P, Urtti A, Männistö PT, Raasmaja A. 2004. International journal of pharmaceutics. 270: 175-184

Different synergistic roles of small polyethylenimine and Dosper in gene delivery

Lampela P, Elomaa M, Ruponen M, Urtti A, Männistö PT, Raasmaja A. 2003. Journal of controlled release. 88: 173-183

Elektrodianturi

Valjakka A, Urtti A, Ahonen J. 2003.

Epidermal cell culture model derived from rat keratinocytes with permeability characteristics comparable to human cadaver skin

Suhonen TM, Pasonen-Seppänen S, Kirjavainen M, Tammi M, Tammi R, Urtti A. 2003. European journal of pharmaceutical sciences. 20: 107-113

Extracellular and intracellular barriers in non-viral gene delivery

Ruponen M, Honkakoski P, Rönkkö S, Pelkonen J, Tammi M, Urtti A. 2003. Journal of controlled release. 93: 213-217

Microemulsions for topical delivery of estradiol

Peltola S, Saarinen-Savolainen P, Kiesvaara J, Suhonen TM, Urtti A. 2003. International journal of pharmaceutics. 254: 99-107

Näköstimulaatiolaite

Valjakka A, Urtti A, Ahonen J. 2003.

Ocular pharmacokinetic modeling using corneal absorption and desorption rates from in vitro permeation experiments with cultured corneal epithelial cells

Ranta V-P, Laavola M, Toropainen E, Vellonen K-S, Talvitie A, Urtti A. 2003. Pharmaceutical research. 20: 1409-1416

Paracellular and passive transcellular permeability in immortalized human corneal epithelial cell culture model

Toropainen E, Ranta V-P, Vellonen K-S, Palmgrén J, Talvitie A, Laavola M, Suhonen P, Hämäläinen KM, Auriola S, Urtti A. 2003. European journal of pharmaceutical sciences. 20: 99-106

Poly-L-glutamic acid derivatives as multifunctional vectors for gene delivery. Part B. Biological evaluation

Dubruel P, Dekie L, Christiaens B, Vanloo B, Rosseneu M, Van De Kerckhove J, Mannisto M, Urtti A, Schacht E. 2003. Biomacromolecules. 4: 1177-1183

Retina-specific gene expression and improved DNA transfection in WERI-Rb1 retinoblastoma cells

Reinisalo M, Urtti A, Honkakoski P. 2003. BIOCHIMICA ET BIOPHYSICA ACTA - GENE STRUCTURE AND EXPRESSION. 1628: 169-176

Retinal disease models for development of drug and gene therapies

Pitkänen L, Salminen L, Urtti A. Teoksessa: Mitra AK(toim.) , 2003. Ophthalmic Drug Delivery Systems. s. 515-533. Marcel Dekker

Vitreous is a barrier in nonviral gene transfer by cationic lipids and polymers

Pitkänen L, Ruponen M, Nieminen J, Urtti A. 2003. Pharmaceutical research. 20: 576-583

Cell membranes as barriers for the use of antisense therapeutic agents

Jääskeläinen I, Urtti A. 2002. Mini-reviews in medicinal chemistry. 2: 307-318

Conformation and ion-binding of oligonucleotides

Kontturi A-K, Kontturi K, Urtti A. 2002. European journal of pharmaceutical sciences. 15: 379-385

Effect of the enzyme inhibitor, phenylmethylsulfonyl fluoride, on the IOP profiles of topical anandamides

Laine K, Järvinen K, Pate DW, Urtti A, Järvinen T. 2002. Investigative ophthalmology and visual science. 43: 393-397

Extracellular and intracellular factors influencing gene transfection mediated by 1,4-dihydropyridine amphiphiles

Hyvönen Z, Ruponen M, Rönkkö S, Suhonen P, Urtti A. 2002. European journal of pharmaceutical sciences. 15: 449-460

In vitro delivery of antisense oligonucleotides

Jääskeläinen I, Honkakoski P, Urtti A. 2002. Cellular and molecular biology letters. 7: 236-237

Liquid chromatographic-electrospray ionization mass spectrometric analysis of neutral and charged polyethylene glycols

Palmgrén JJ, Toropainen E, Auriola S, Urtti A. 2002. Journal of chromatography a. 976: 165-170

Menetelmä farmaseuttisen koostumuksen valmistamiseksi

Järvinen T, Järvinen K, Urtti A, Pate DW. 2002.

Simultaneous determination of eight beta-blockers by gradient high-performance liquid chromatography with combined ultraviolet and fluorescence detection in corneal permeability studies in vitro

Ranta V-P, Toropainen E, Talvitie A, Auriola S, Urtti A. 2002. Journal of chromatography b: analytical technologies in the biomedical and life sciences. 772: 81-87

Structure-activity relationships of poly(L-lysines): effects of pegylation and molecular shape on physicochemical and biological properties in gene delivery

Männistö M, Vanderkerken S, Toncheva V, Elomaa M, Ruponen M, Schacht E, Urtti A. 2002. Journal of controlled release. 83: 169-182

Uusi genomitieto lääkekehityksen ja lääkehoidon avuksi

Urtti A. 2002. Dosis. 18: 154-160

A novel drug-regulated gene expression system based on the nuclear receptor constitutive androstane receptor (CAR)

Honkakoski P, Jääskeläinen I, Kortelahti M, Urtti A. 2001. Pharmaceutical research. 18: 146-150

Culture model of human corneal epithelium for prediction of ocular drug absorption

Toropainen E, Ranta V-P, Talvitie A, Suhonen P, Urtti A. 2001. Investigative ophthalmology and visual science. 42: 2942-2948

Extracellular glycosaminoglycans modify cellular trafficking of lipoplexes and polyplexes

Ruponen M, Rönkkö S, Honkakoski P, Pelkonen J, Tammi M, Urtti A. 2001. Journal of biological chemistry. 276: 33875-33880

Formation of permeability barrier in epidermal organotypic culture for studies on drug transport

Pasonen-Seppänen S, Suhonen TM, Kirjavainen M, Miettinen M, Urtti A, Tammi M, Tammi R. 2001. Journal of investigative dermatology

Genomic structure of proton-coupled oligopeptide transporter hPEPT1 and pH-sensing regulatory splice variant

Urtti A, Sadée W, Johns SJ. 2001. AAPS journal. 3:

Lipid bilayers in cells: implications in drug and gene delivery

Suhonen TM, Suhonen P, Urtti A. Teoksessa: Volkov AG(toim.) , 2001. Liquid Interfaces in Chemical, Biological, and Pharmaceutical Applications. s. 807-844. Markel Dekker

Vitamin C enhances differentation of a continuous keratinocyte cell line (REK) into epidermis with normal stratum corneum ultrastructure and functional permeability barrier

Pasonen-Seppänen S, Suhonen TM, Kirjavainen M, Suihko E, Urtti A, Miettinen M, Hyttinen M, Tammi M, Tammi R. 2001. Histochemistry and cell biology. 116: 287-297

A lipid carrier with a membrane active component and a small complex size are required for efficient cellular delivery of anti-sense phosphorothioate oligonucleotides

Jääskeläinen I, Peltola S, Honkakoski P, Mönkkönen J, Urtti A. 2000. European journal of pharmaceutical sciences. 10: 187-193

Controlled transdermal iontophoresis by ion-exchange fiber

Jaskari T, Vuorio M, Kontturi K, Urtti A, Manzanares JA, Hirvonen J. 2000. Journal of controlled release. 67: 179-190

Enzymatic and permeation barrier of [D-Ala2]-met-enkephalinamide in the anterior membranes of the albino rabbit eye

Hämäläinen KM, Ranta V-P, Auriola S, Urtti A. 2000. European journal of pharmaceutical sciences. 9: 265-270

Gene delivery and expression in human retinal pigment epithelial cells: effects of synthetic carriers, serum, extracellular matrix and viral promoters

Urtti A, Polansky J, Lui GM, Szoka FC. 2000. Journal of drug targeting. 7: 413-421

Influence of lipids on the mannitol flux during transdermal iontophoresis in vitro

Kirjavainen M, Urtti A, Mönkkönen J, Hirvonen J. 2000. European journal of pharmaceutical sciences. 10: 97-102

Novel cationic amphiphilic 1,4-dihydropyridine derivatives for DNA delivery

Hyvönen Z, Plotniece A, Reine I, Chekavichus B, Duburs G, Urtti A. 2000. Biochimica et biophysica acta: biomembranes. 1509: 451-466

Synthesis and evaluation of poly(ethylene glycol)-polylysine block copolymers as carriers for gene delivery

Vanderkerken S, Vanheede T, Toncheva V, Schacht E, Wolfert MA, Seymour L, Urtti A. 2000. Journal of bioactive and compatible polymers. 15: 115-138

Transdermal delivery of levosimendan

Valjakka-Koskela R, Hirvonen J, Mönkkönen J, Kiesvaara J, Antila S, Lehtonen L, Urtti A. 2000. European journal of pharmaceutical sciences. 11: 343-350

Water-activated, pH-controlled patch in transdermal administration of timolol: I. Preclinical tests

Sutinen R, Paronen P, Urtti A. 2000. European journal of pharmaceutical sciences. 11: 19-24

Water-activated, pH-controlled patch in transdermal administration of timolol: II. Drug absorption and skin irritation

Sutinen R, Paronen P, Saano V, Urtti A. 2000. European journal of pharmaceutical sciences. 11: 25-31

Anandamide analog compositions and method of treating intraocular hypertension using same

Pate DW, Jarvinen T, Jarvinen K, Urtti A. 1999.

Chemical enhancement of percutaneous absorption in relation to stratum corneum structural alterations

Suhonen TM, Bouwstra JA, Urtti A. 1999. Journal of controlled release. 59: 149-161

Contrasting effects of alendronate and clodronate on RAW 264 macrophages: the role of a bisphosphonate metabolite

Makkonen N, Salminen A, Rogers MJ, Frith JC, Urtti A, Azhayeva E, Mönkkönen J. 1999. European journal of pharmaceutical sciences. 8: 109-118

Drug release from cation exchange membrane in rabbit eye

Tarvainen T, Svarfvar B, Sääskilahti M, Urtii A, Paronen P, Järvinen K. 1999. Journal of ocular pharmacology and therapeutics. 15: 497-504

Efficient adventitial gene delivery to rabbit carotid artery with cationic polymer-plasmid complexes

Turunen MP, Hiltunen MO, Ruponen M, Virkamäki L, Szoka FC Jr, Urtti A, Ylä-Herttuala S. 1999. Gene therapy. 6: 6-11

Influence of ionic strength on drug adsorption onto and release from a poly(acrylic acid) grafted poly(vinylidene fluoride) membrane

Åkerman S, Svarfvar B, Kontturi K, Näsman J, Urtti A, Paronen P, Järvinen K. 1999. International journal of pharmaceutics. 178: 67-75

Interactions of polymeric and liposomal gene delivery systems with extracellular glycosaminoglycans: physicochemical and transfection studies

Ruponen M, Ylä-Herttuala S, Urtti A. 1999. Biochimica et biophysica acta: international journal of biochemistry and biophysics. 1415: 331-341

Liposome-skin interactions and their effects on the skin permeation of drugs

Kirjavainen M, Urtti A, Valjakka-Koskela R, Kiesvaara J, Mönkkönen J. 1999. European journal of pharmaceutical sciences. 7: 279-286

Peptide-oligonucleotide phosphorothioate conjugates with membrane translocation and nuclear localization properties

Antopolsky M, Azhayeva E, Tengvall U, Auriola S, Jääskeläinen I, Rönkkö S, Honkakoski P, Urtti A, Lönnberg H, Azhayev A. 1999. Bioconjugate chemistry. 10: 598-606

Pharmacokinetics and safety of deramciclane during multiple oral dosing

Kanerva H, Kilkku O, Helminen A, Rouru J, Scheinin M, Huupponen R, Klebovich I, Drabant S, Urtti A. 1999. International journal of clinical pharmacology and therapeutics. 37: 589-597

Phospholipids affect stratum corneum lipid bilayer fluidity and drug partitioning into the bilayers

Kirjavainen M, Mönkkönen J, Saukkosaari M, Valjakka-Koskela R, Kiesvaara J, Urtti A. 1999. Journal of controlled release. 58: 207-214

The single dose pharmacokinetics and safety of deramciclane in healthy male volunteers

Kanerva H, Kilkku O, Heinonen E, Helminen A, Rouru J, Tarpila S, Scheinin M, Huupponen R, Klebovich I, Drabant S, Urtti A. 1999. Biopharmaceutics and drug disposition. 20: 327-334

Comparative pharmacokinetics of deramciclane in rat, dog, rabbit and man after the administration of a single oral dose of 3 mg kg -1

Klebovich I, Kanerva H, Bojti E, Urtti A, Drabant S. 1998. PHARMACY AND PHARMACOLOGY COMMUNICATIONS. 4: 129-136

Comparative pharmacokinetics of deramciclane in various species (rat, dog, rabbit, human) after the administration of a single oral dose of 3 mg kg -1

Klebovich I, Kanerva H, Bojti E, Urtti A, Drabant S. 1998. PHARMACY AND PHARMACOLOGY COMMUNICATIONS. 4: 1-9

Different absorption profiles of deramciclane in man and in dog

Kanerva H, Klebovich I, Drabant S, Urtti A, Nevalainen T. 1998. Journal of pharmacy and pharmacology. 50: 1087-1093

Different effects of pH on the permeation of pilocarpine and pilocarpine prodrugs across the isolated rabbit cornea

Suhonen P, Järvinen T, Koivisto S, Urtti A. 1998. European journal of pharmaceutical sciences. 6: 169-176

Drug permeation through a temperature-sensitive poly(N-isopropylacrylamide) grafted poly(vinylidene fluoride) membrane

Åkerman S, Viinikka P, Svarfvar B, Putkonen K, Järvinen K, Kontturi K, Näsman J, Urtti A, Paronen P. 1998. International journal of pharmaceutics. 164: 29-36

Effect of the CB1 receptor antagonist, SR141716A, on cannabinoid-induced ocular hypotension in normotensive rabbits

Pate DW, Järvinen K, Urtti A, Mahadevan V, Järvinen T. 1998. Life sciences. 63: 2181-2188

Enhancement of percutaneous absorption of naproxen by phospholipids

Valjakka-Koskela R, Kirjavainen M, Mönkkönen J, Urtti A, Kiesvaara J. 1998. International journal of pharmaceutics. 175: 225-230

Evaluation of cytotoxicity of various ophthalmic drugs, eye drop excipients and cyclodextrins in an immortalized human corneal epithelial cell line

Saarinen-Savolainen P, Järvinen T, Araki-Sasaki K, Watanabe H, Urtti A. 1998. Pharmaceutical research. 15: 1275-1280

Geenilääkkeet tulevat

Urtti A. 1998. Dosis. 14: 183-190

Gradient high-performance liquid chromatographic analysis of enkephalin peptides, their metabolites, and enzyme inhibitors using combined ultraviolet and electrochemical detection. II. Application to ocular permeability studies in vitro

Ranta V-P, Hämäläinen KM, Auriola S, Urtti A. 1998. Journal of chromatography b: analytical technologies in the biomedical and life sciences. 709: 1-10

Lipid fusion in oligonucleotide and gene delivery with cationic lipids

Mönkkönen J, Urtti A. 1998. Advanced drug delivery reviews. 34: 37-49

Pharmacokinetics of deramciclane in dogs after single oral and intravenous dosing and multiple oral dosing

Kanerva H, Huuskonen H, Alhonen-Raatesalmi A, Nevalainen T, Urtti A. 1998. Biopharmaceutics and drug disposition. 19: 531-539

Physicochemical and morphological properties of complexes made of cationic liposomes and oligonucleotides

Jääskeläinen I, Sternberg B, Mönkkönen J, Urtti A. 1998. International journal of pharmaceutics. 167: 191-203

Roles of acid/base nature and molecular weight in drug release from matrices of gelfoam and monoisopropyl ester of poly(vinyl methyl ether-maleic anhydride)

Hämäläinen KM, Määttä E, Piirainen H, Sarkola M, Väisänen A, Ranta V-P, Urtti A. 1998. Journal of controlled release. 56: 273-283

Transport of drugs across porous ion exchange membranes

Åkerman S, Viinikka P, Svarfvar B, Järvinen K, Kontturi K, Näsman J, Urtti A, Paronen P. 1998. Journal of controlled release. 50: 153-166

Analysis of oligonucleotides with capillary electrophoresis electrospray mass spectrometry

Auriola S, Thibault P, Koivuniemi A, Jääskeläinen I, Urtti A. Teoksessa: (toim.) , 1997. The 45th ASMS Conference on Mass Spectrometry and Allied Topics. Proceedings.. s. 651.

Anandamides useful for the treatment of intraocular hypertension, ophthalmic compositions containing the same and methods of use of the same

Pate DW, Jarvinen T, Jarvinen K, Urtti A. 1997.

Beta-cyclodextrin derivatives (2-HP-beta-CD, SBE4-beta-CD) decrease the amphiphilicity and membrane perturbing effects of pilocarpine prodrugs

Saarinen-Savolainen P, Urtti A, Jarho P, Järvinen T. 1997. European journal of pharmaceutical sciences. 5: 89-96

Characterization of paracellular and aqueous penetration routes in cornea, conjunctiva, and sclera

Hämäläinen KM, Kananen K, Auriola S, Kontturi K, Urtti A. 1997. Investigative ophthalmology and visual science. 38: 627-634

Composition for pH dependent controlled release of active ingredients and method for producing it

Urtti AO, Peltonen SH, Paronen TP, Nakari LJ, Vuorenpää J-E. 1997.

Effects of Topical alpha-substituted anandamides on intraocular pressure in normotensive rabbits

Pate DW, Järvinen K, Urtti A, Jarho P, Mahadevan V, Järvinen T. 1997. Pharmaceutical research. 14: 1738-1743

Effects of phospholipids on the percutaneous penetration of sotalol and propranolol

Kirjavainen M, Urtti A, Mönkkönen J. Teoksessa: Couvreur P, Duchêne D, Green P, Junginger HE(toim.) , 1997. Transdermal Administration, a Case Study, Iontophoresis. European Symposium. s. 221-225. Éditions de Santé

Esterové deriváty kyseliny bispilokarpové, zpusob jejich prípravy a farmaceuticky prostredek je obsahující

Järvinen T, Peura P, Suhonen P, Urtti A, Hanhijärvi H, Pohjala E. 1997.

Estimation of pore size and pore density of biomembranes from permeability measurements of polyethylene glycols using an effusion-like approach

Hämäläinen KM, Kontturi K, Auriola S, Murtomäki L, Urtti A. 1997. Journal of controlled release. 49: 97-104

Farmasia ja tiedepolitiikan uudet tuulet

Urtti A. 1997. Dosis

Gradient high-performance liquid chromatographic analysis of enkephalin peptides, their metabolites and enzyme inhibitors using combined ultraviolet and electrochemical detection. I. Optimization of separation and detection

Ranta V-P, Urtti A, Auriola S. 1997. Journal of chromatography a. 766: 85-97

Inhibitory properties of double helix forming circular oligonucleotides

Azhayeva E, Azhayev A, Auriola S, Tengvall U, Urtti A, Lönnberg H. 1997. Nucleic acids research. 25: 4954-4961

Menetelmä farmaseuttisesti käyttökelpoisten pilokarpiinijohdannaisten valmistamiseksi

Järvinen T, Peura P, Suhonen P, Urtti A, Hanhijärvi H, Pohjala E. 1997.

Menetelmä farmaseuttisesti käyttökelpoisten pilokarpiinijohdannaisten valmistamiseksi

Järvinen T, Peura P, Suhonen P, Urtti A, Hanhijärvi H, Pohjala E. 1997.

Menetelmä uusien, farmakologisesti käyttökelpoisten bispilokarpiinihapon esterijohdannaisten valmistamiseksi

Järvinen T, Peura P, Suhonen P, Urtti A, Hanhijärvi H, Pohjala E. 1997.

Method for evaluating drug release from liposomes in sink conditions

Saarinen-Savolainen P, Järvinen T, Taipale H, Urtti A. 1997. International journal of pharmaceutics. 159: 27-33

New drug release test for liposomes

Saarinen-Savolainen P, Järvinen T, Taipale H, Urtti A. Teoksessa: (toim.) , 1997. The 24th International Symposium on Controlled Release of Bioactive Materials. Proceedings. s. 1041. Controlled Release Society

Permeation of FITC-dextrans through temperature sensitive polymer membrane

Åkerman S, Viinikka P, Svarfvar B, Putkonen K, Järvinen K, Kontturi K, Näsman J, Urtti A, Paronen P. Teoksessa: (toim.) , 1997. The 24th International Symposium on Controlled Release of Bioactive Materials. Proceedings.. s. 1039-1040. Controlled Release Society

Starch acetate composition with modifiable properties, method for preparation and usage thereof

Paronen TP, Peltonen SH, Urtti AO, Nakari LJ. 1997.

Starch acetates - multifunctional excipients for tabletting

Raatikainen P, Paronen P, Peltonen S, Nakari J, Urtti A. Teoksessa: (toim.) , 1997. 16th Pharmaceutical Technology Conference and Exhibition. Vol. 2.. s. 192-216.

The use of cyclodextrins in ophthalmic formulations of dipivefrin

Jarho P, Järvinen K, Urtti A, Stella VJ, Järvinen T. 1997. International journal of pharmaceutics. 153: 225-233

Tilastokummajaisia

Urtti A. 1997. Dosis

Transepidermal delivery of ß-blocking agents: evaluation of enhancer effects using stratum corneum lipid liposomes1

Suhonen TM, Pirskanen L, Räisänen M, Kosonen K, Rytting JH, Paronen P, Urtti A. 1997. Journal of controlled release. 43: 251-259

Tutkijakoulu tuli

Urtti A. 1997. Dosis

Accumulation of bisphosphonates in the aorta and some other tissues of healthy and atherosclerotic rabbits

Ylitalo R, Mönkkönen J, Urtti A, Ylitalo P. 1996. Translational research. 127: 200-206

Amphiphilic properties of pilocarpine prodrugs

Saarinen-Savolainen P, Järvinen T, Suhonen P, Urtti A. 1996. International journal of pharmaceutics. 133: 171-178

Analysis of oligonucleotides by on-column transient capillary isotachophoresis and capillary electrophoresis in poly(ethylene glycol)-filled columns

Auriola S, Jääskeläinen I, Regina M, Urtti A. 1996. Analytical chemistry. 68: 3907-3911

Effect of cyclodextrin on the drug release from pH-controlled silicone microspheres

Sutinen R, Kekki M, Paronen P, Urtti A. Teoksessa: Couvreur P, Duchêne D, Kalles I(toim.) , 1996. European Symposium on Formulation of Poorly-Available Drugs for Oral Administration. s. 261-264. Editions de Santé

Effects of topical anandamides on intraocular pressure in normotensive rabbits

Pate DW, Järvinen K, Urtti A, Jarho P, Fich M, Mahadevan V, Järvinen T. 1996. Life sciences. 58: 1849-1860

Hydroxypropyl-ß-cyclodextrin increases aqueous solubility and stability of anandamide

Jarho P, Urtti A, Järvinen K, Pate DW, Järvinen T. 1996. Life sciences. 58: 181-185

Increase in aqueous solubility, stability and in vitro corneal permeability of anandamide by hydroxypropyl-ß-cyclodextrin

Jarho P, Urtti A, Pate DW, Suhonen P, Järvinen T. 1996. International journal of pharmaceutics. 137: 209-216

Interaction of liposomes with human skin in vitro - the influence of lipid composition and structure

Kirjavainen M, Urtti A, Jääskeläinen I, Suhonen TM, Paronen P, Valjakka-Koskela R, Kiesvaara J, Mönkkönen J. 1996. Biochimica et biophysica acta: international journal of biochemistry and biophysics. 1304: 179-189

Modified ß-cyclodextrin (SBE7-ß-CyD) with viscous vehicle improves the ocular delivery and tolerability of pilocarpine prodrug in rabbits

Jarho P, Järvinen K, Urtti A, Stella VJ, Järvinen T. 1996. Journal of pharmacy and pharmacology. 48: 263-269

Ne fuusiot

Urtti A. 1996. Dosis

Novel pilocarpine derivatives and process for their preparation

Jarvinen T, Peura P, Suhonen P, Urtti A, Hanhijarvi H, Pohjala E. 1996.

Oppia ikä kaikki

Urtti A. 1996. Dosis

Peroral drug delivery system

Urtti AO, Sutinen MR, Paronen TP. 1996.

Rate control of ocular pilocarpine delivery with bispilocarpic acid diesters

Suhonen P, Järvinen T, Lehmussaari K, Reunamäki T, Urtti A. 1996. International journal of pharmaceutics. 127: 85-94

The effect of SBE7-ß-CD with viscous vehicle on ocular delivery of pilocarpine prodrug in rabbits

Jarho P, Järvinen K, Urtti A, Stella VJ, Järvinen T. Teoksessa: Szejtli J, Szente L(toim.) , 1996. Proceedings of the Eighth International Symposium on Cyclodextrons. s. 399-402. Kluwer

The effects of HP-ß-CD on aqueous solubility, stability and in vitro corneal penetration of anandamide

Jarho P, Urtti A, Pate DW, Suhonen P, Järvinen T. Teoksessa: Szejtli J, Szente L(toim.) , 1996. Proceedings of the Eight International Symposium on Cyclodextrons. s. 395-398. Kluwer

Bispilocarpic acid ester derivatives and process for their preparation

Järvinen T, Peura P, Suhonen P, Urtti A, Hanhijärvi H, Pohjala E. 1995.

Buffer controlled release of indomethacin from ethylcellulose microcapsules

Tirkkonen S, Urtti A, Paronen P. 1995. International journal of pharmaceutics. 124: 219-229

Comparison of enzymatic hydrolysis of pilocarpine prodrugs in human plasma, rabbit cornea, and butyrylcholinesterase solutions

Järvinen T, Poikolainen M, Suhonen P, Vepsäläinen J, Alaranta S, Urtti A. 1995. Journal of pharmaceutical sciences. 84: 656-660

Composition for ophthalmic use

Urtti A, Järvinen T, Suhonen P, Lehmussaari K, Reunamäki T, Alaranta S, Oksala O, Pohjala E, Hanhijärvi H. 1995.

Composition for ophthalmic use

Jaervinen T, Urtti A, Suhonen P, Peura P, Lehmussaari K, Reunamaeki T, Alaranta S, Oksala O, Pohjala E, Hanhijaervi H. 1995.

Composition for ophthalmic use

Järvinen T, Urtti A, Suhonen P, Peura P, Lehmussaari K, Reunamäki T, Alaranta S, Oksala O, Pohjala E, Hanhijärvi H. 1995.

Composition for ophthalmic use

Urtti A, Jaervinen T, Suhonen P, Lehmussaari K, Reunamaeki T, Alaranta S, Oksala O, Pohjala E, Hanhijaervi H. 1995.

Effect of liposomal and free bisphosphonates on the IL-1ß, IL-6 and TNFAlfa secretion from RAW 264 cells in vitro

Pennanen N, Lapinjoki S, Urtti A, Mönkkönen J. 1995. Pharmaceutical research. 12: 916-922

Hydroxypropyl-ß-cyclodextrin increases the aqueous solubility and stability of pilocarpine prodrugs

Jarho P, Urtti A, Järvinen T. 1995. Pharmaceutical research. 12: 1371-1375

Kinetic aspects in the design of prolonged action ocular drug delivery systems

Urtti A. 1995. ADVANCES IN PHARMACEUTICAL SCIENCES. 7: 63-92

Komposition för topisk administration av bispilokarpinsyradiestrar till ögat i form av en vattenlösning

Urtti A, Järvinen T, Suhonen P, Peura P, Lehmussaari K, Reunamäki T, Oksala O, Alaranta S, Pohjala E, Hanhijärvi H. 1995.

Komposition för topisk administration av bispilokarpinsyradiestrar till ögat i form av en vattenlösning

Urtti A, Järvinen T, Suhonen P, Lehmussaari K, Reunamäki T, Alaranta S, Oksala O, Pohjala E, Hanhijärvi H. 1995.

Macrophage-like RAW 264 cell line and time-resolved fluoroimmunoassay (TRFIA) as tools in screening drug effects on cytokine secretion

Pennanen N, Lapinjoki S, Palander A, Urtti A, Mönkkönen J. 1995. INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY. 17: 475-480

Mechanisms of transdermal penetration enhancement

Urtti A. Teoksessa: (toim.) , 1995. Proceedings of the 22nd International Symposium on Controlled Release of Bioactive Materials. s. 115-116.

Novel pilocarpine derivatives and process for their preparation

Järvinen T, Peura P, Suhonen P, Urtti A, Hanhijärvi H, Pohjala E. 1995.

Novel pilocarpine derivatives and process for their preparation

Järvinen T, Peura P, Suhonen P, Urtti A, Hanhijärvi H, Pohjala E. 1995.

Novel pilocarpine derivatives and process for their preparation

Jaervinen T, Peura P, Suhonen P, Urtti A, Hanhijaervi H, Pohjala E. 1995.

Novel pilocarpine derivatives and process for their preparation

Järvinen T, Peura P, Suhonen P, Urtti A, Hanhijärvi H, Pohjala E. 1995.

Novel pilocarpine derivatives and process for their preparation

Järvinen T, Peura P, Suhonen P, Urtti A, Hanhijärvi H, Pohjala E. 1995.

Ocular absorption and irritation of pilocarpine prodrug is modified with buffer, polymer, and cyclodextrin in the eyedrop

Suhonen P, Järvinen T, Lehmussaari K, Reunamäki T, Urtti A. 1995. Pharmaceutical research. 12: 529-533

Ocular absorption following topical delivery

Järvinen K, Järvinen T, Urtti A. 1995. Advanced drug delivery reviews. 16: 3-19

Ophthalmic arachidonylethanolamide decreases intraocular pressure in normotensive rabbits

Pate DW, Järvinen K, Urtti A, Jarho P, Järvinen T. 1995. Current eye research. 14: 791-797

Studies on liposome formulations for intra-articular delivery of clodronate

Mönkkönen J, Liukkonen J, Taskinen M, Heath TD, Urtti A. 1995. Journal of controlled release. 35: 145-154

Sulfobutyl ether ß-cyclodextrin (SBE-ß-CD) in eyedrops improves the tolerability of a topically applied pilocarpine prodrug in rabbits

Järvinen T, Järvinen K, Urtti A, Thompson D, Stella VJ. 1995. Journal of ocular pharmacology and therapeutics. 11: 95-106

Voidaanko eläinkokeet korvata in vitro -menetelmillä silmä-ärsytystutkimuksissa

Saarinen-Savolainen P, Järvinen T, Urtti A. 1995. Dosis. 11: 69-76

pH-controlled silicone microspheres for controlled drug delivery

Sutinen R, Laasanen V, Paronen P, Urtti A. 1995. Journal of controlled release. 33: 163-171

Controlled ocular timolol delivery: systemic absorption and intraocular pressure effects in humans

Urtti A, Rouhiainen H, Kaila T, Saano V. 1994. Pharmaceutical research. 11: 1278-1282

Tarkenna hakuasi

Tutkimusryhmät

Projektit

Avainsanat

Comprehensive ocular and systemic pharmacokinetics of dexamethasone after subconjunctival and intravenous injections in rabbits

Aldehyde oxidase 1 activity and protein expression in human, rabbit, and pig ocular tissues

Intravitreal CendR peptides target laser-induced choroidal neovascularization sites in mice

Mass spectrometry in ocular drug research

Paljon on muuttunut sitten 1970- ja 1980-lukujen

Quantitative intravitreal pharmacokinetics in mouse as a step towards inter-species translation

Selective drug delivery to the retinal cells: Biological barriers and avenues

Tailoring surface properties of liposomes for dexamethasone intraocular administration

The prophylactic value of TNF‐α inhibitors against retinal cell apoptosis and optic nerve axon loss after corneal surgery or trauma

Topical pharmacokinetics of brinzolamide suspensions in rabbits and variability analysis for sample size and design considerations

5-(Sulfamoyl)thien-2-yl 1,3-oxazole inhibitors of carbonic anhydrase II with hydrophilic periphery

A Novel Ferroptosis Inhibitor UAMC-3203, a Potential Treatment for Corneal Epithelial Wound

Activity and expression of carboxylesterases and arylacetamide deacetylase in human ocular tissues

Antiangiogenic AAV2 gene therapy with a truncated form of soluble VEGFR-2 reduces the growth of choroidal neovascularization in mice after intravitreal injection

Comments on “Ocular Pharmacokinetics of Brimonidine Drug Delivery System in Monkeys and Translational Modeling for Selection of Dose and Frequency in Clinical Trials”

Imaging, quantitation and kinetic modelling of intravitreal nanomaterials

Improved ocular delivery of quercetin and resveratrol: A comparative study between binary and ternary cyclodextrin complexes

Liposomal sunitinib for ocular drug delivery: A potential treatment for choroidal neovascularization

Mechanisms of cellular retention of melanin bound drugs: Experiments and computational modeling

Ocular metabolism and distribution of drugs in the rabbit eye: Quantitative assessment after intracameral and intravitreal administrations

Pharmacoproteomics of Brain Barrier Transporters and Substrate Design for the Brain Targeted Drug Delivery

Quantitative pharmacokinetic analyses of anterior and posterior elimination routes of intravitreal anti-VEGF macromolecules using published human and rabbit data

Swarms of chemically modified antiviral siRNA targeting herpes simplex virus infection in human corneal epithelial cells

The Effect of Microbubble-Assisted Ultrasound on Molecular Permeability across Cell Barriers

Topical pharmacokinetics of dexamethasone suspensions in the rabbit eye: Bioavailability comparison

Understanding dexamethasone kinetics in the rabbit tear fluid: Drug release and clearance from solution, suspension and hydrogel formulations

Biopharmaceutics of Topical Ophthalmic Suspensions: Importance of Viscosity and Particle Size in Ocular Absorption of Indomethacin

Carboxylesterase Activities and Protein Expression in Rabbit and Pig Ocular Tissues

Conformationally Constrained Peptides with High Affinity to the Vascular Endothelial Growth Factor

Cowpea Chlorotic Mottle Virus-Like Particles as Potential Platform for Antisense Oligonucleotide Delivery in Posterior Segment Ocular Diseases

Inhibition of prolyl oligopeptidase: A promising pathway to prevent the progression of age-related macular degeneration

Intravitreal Polymeric Nanocarriers with Long Ocular Retention and Targeted Delivery to the Retina and Optic Nerve Head Region

Magnetically Assisted Drug Delivery of Topical Eye Drops Maintains Retinal Function In Vivo in Mice

Mucoadhesive properties of nanogels based on stimuli-sensitive glycosaminoglycan-graft-pNIPAAm copolymers

Ocular pharmacokinetics of atenolol, timolol and betaxolol cocktail: tissue exposures in the rabbit eye

Oxidative Stress and Mitochondrial Damage in Dry Age-Related Macular Degeneration Like NFE2L2/PGC-1[alpha] -/- Mouse Model Evoke Complement Component C5a Independent of C3

Partitioning and Spatial Distribution of Drugs in Ocular Surface Tissues

Peptide Inhibitors of Vascular Endothelial Growth Factor A: Current Situation and Perspectives

Pharmacokinetics of Pullulan–Dexamethasone Conjugates in Retinal Drug Delivery

Pharmacokinetics of intravitreal macromolecules: scaling between rats and rabbits

Pullulan Based Bioconjugates for Ocular Dexamethasone Delivery

Retinal neuroprotection by controlled release of a VCP inhibitor from self-assembled nanoparticles

Screening of chemical linkers for development of pullulan bioconjugates for intravitreal ocular

Statins for the prevention of proliferative vitreoretinopathy: cellular responses in cultured cells and clinical statin concentrations in the vitreous

Ultrasound and Microbubbles for the Treatment of Ocular Diseases: From Preclinical Research towards Clinical Application

Amphiphilic Polypeptides for VEGF siRNA Delivery into Retinal Epithelial Cells

Avoiding the Pitfalls of siRNA Delivery to the Retinal Pigment Epithelium with Physiologically Relevant Cell Models.

Characterization, Stability, and in Vivo Efficacy Studies of Recombinant Human CNTF and Its Permeation Into the Neural Retina in Ex Vivo Organotypic Retinal Explant Culture Models

Comprehensive Ocular and Systemic Pharmacokinetics of Brinzolamide in Rabbits After Intracameral, Topical, and Intravenous Administration

Design and synthesis of lipid-mimetic cationic iridium complexes and their liposomal formulation for in vitro and in vivo application in luminescent bioimaging

Diffusion and Protein Corona Formation of Lipid-Based Nanoparticles in the Vitreous Humor: Profiling and Pharmacokinetic Considerations

Extended Pharmacokinetic Model of the Intravitreal Injections of Macromolecules in Rabbits. Part 2: Parameter Estimation Based on Concentration Dynamics in the Vitreous, Retina, and Aqueous Humor

Hexosome engineering for targeting of regional lymph nodes

Intravitreal hydrogels for sustained release of therapeutic proteins

Light-Activated Liposomes Coated with Hyaluronic Acid as a Potential Drug Delivery System

Microflow-Based Device for In Vitro and Ex Vivo Drug Permeability Studies

Microscale Thermophoresis as a Screening Tool to Predict Melanin Binding of Drugs

Mitophagy in the Retinal Pigment Epithelium of Dry Age-Related Macular Degeneration Investigated in the NFE2L2/PGC-1α-/- Mouse Model

Ocular barriers to retinal delivery of intravitreal liposomes: Impact of vitreoretinal interface

Prodrug Approach for Posterior Eye Drug Delivery: Synthesis of Novel Ganciclovir Prodrugs and in Vitro Screening with Cassette Dosing

Release of functional dexamethasone by intracellular enzymes: A modular peptide-based strategy for ocular drug delivery

The effect of prolyl oligopeptidase inhibitors on alpha-synuclein aggregation and autophagy cannot be predicted by their inhibitory efficacy

Topical ocular pharmacokinetics and bioavailability for a cocktail of atenolol, timolol and betaxolol in rabbits

Artificially cloaked viral nanovaccine for cancer immunotherapy

CD44 aptamer mediated cargo delivery to lysosomes of retinal pigment epithelial cells to prevent age-related macular degeneration

Characterization of CDNF-Secreting ARPE-19 Cell Clones for Encapsulated Cell Therapy

Characterization of artificially re-pigmented ARPE-19 retinal pigment epithelial cell model

Comment on "Topical Delivery of Avastin to the Posterior Segment of the Eye In Vivo Using Annexin A5-Associated Liposomes": Topical Liposomal Bevacizumab Results in Negligible Retinal Concentrations

Design principles of ocular drug delivery systems: importance of drug payload, release rate, and material properties

Distribution of Small Molecular Weight Drugs into the Porcine Lens: Studies on Imaging Mass Spectrometry, Partition Coefficients, and Implications in Ocular Pharmacokinetics

Electrical synapses interconnecting axons revealed in the optic nerve head - a novel model of gap junctions' involvement in optic nerve function

Electron dispersive X-ray spectroscopy and degradation properties of hyaluronic acid decorated microparticles

Enhanced Delivery of 4-Thioureidoiminomethylpyridinium Perchlorate in Tuberculosis Models with IgG Functionalized Poly(Lactic Acid)-Based Particles

Establishment of an In Vitro-In Vivo Correlation for Melanin Binding and the Extension of the Ocular Half-Life of Small-Molecule Drugs

Exploring Light-Sensitive Nanocarriers for Simultaneous Triggered Antibiotic Release and Disruption of Biofilms Upon Generation of Laser-Induced Vapor Nanobubbles