
ASLA PITKäNEN
Professori
Yhteystiedot
Organisaatio
Terveystieteiden tiedekunta, A. I. Virtanen -instituutti
Sähköposti
asla.pitkanen@uef.fi
Puhelin
050 517 2091
Tutkimusryhmät - UEF
Julkaisut
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Das Gupta, Shalini; Ciszek, Robert; Heiskanen, Mette; Lapinlampi, Niina; Kukkonen, Janne; Leinonen, Ville; Puhakka, Noora; Pitkänen, Asla. 2021. Plasma miR-9-3p and miR-136-3p as Potential Novel Diagnostic Biomarkers for Experimental and Human Mild Traumatic Brain Injury International journal of molecular sciences 22 4: 1563. 2021
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Pitkänen, Asla. 2021. Voiko epilepsian puhkeamisen ja etenemisen estää lääkehoidolla? Duodecim 137 16: 1631 - 1637. 2021
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Dulla, Chris G.; Pitkänen, Asla. 2021. Novel Approaches to Prevent Epileptogenesis After Traumatic Brain Injury Neurotherapeutics 18 3: 1582-1601. 2021
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Yasmin, Amna; Pitkänen, Asla; Andrade, Pedro; Paananen, Tomi; Gröhn, Olli; Immonen, Riikka. 2021. Post-injury ventricular enlargement associates with iron in choroid plexus but not with seizure susceptibility nor lesion atrophy - 6-month MRI follow-up after experimental traumatic brain injury Brain structure and function 2022; 227 1: 145-158. 2021
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Wang, Ying; Andrade, Pedro; Pitkänen Asta. 2021. Peripheral Infection after Traumatic Brain Injury Augments Excitability in the Perilesional Cortex and Dentate Gyrus Biomedicines 9 12: 1946. 2021
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Simonato, Michele; Agoston, Denes V; Brooks-Kayal, Amy; Dulla, Chris; Fureman, Brandy; Henshall, David C; Pitkänen, Asla; Theodore, William H; Twyman, Roy E; Kobeissy, Firas H; Wang, Kevin K; Whittemore, Vicky; Wilcox, Karen S. 2021. Identification of clinically relevant biomarkers of epileptogenesis - a strategic roadmap Nature reviews neurology 17 4: 231-242. 2021
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Pitkänen, Asla; Paananen, Tomi; Kyyriäinen, Jenni; Das Gupta, Shalini; Heiskanen, Mette; Vuokila, Niina; Bañuelos-Cabrera, Ivette; Lapinlampi, Niina; Kajevu, Natallie; Andrade, Pedro; Ciszek, Robert; Lara-Valderrábano, Leonardo; Ekolle Ndode-Ekane, Xavier; Puhakka, Noora. 2021. Biomarkers for posttraumatic epilepsy Epilepsy and behavior 121 Part B: 107080. 2021
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Ndode-Ekane, Xavier Ekolle; Puigferrat Pérez, Maria del Mar; Di Sapia, Rossella; Lapinlampi, Niina; Pitkänen, Asla. 2021. Reorganization of Thalamic Inputs to Lesioned Cortex Following Experimental Traumatic Brain Injury International journal of molecular sciences 22 12: 6329. 2021
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Manninen, Eppu; Chary, Karthik; Lapinlampi, Niina; Andrade, Pedro; Paananen, Tomi; Sierra, Alejandra; Tohka, Jussi; Gröhn, Olli; Pitkänen, Asla. 2021. Acute thalamic damage as a prognostic biomarker for post-traumatic epileptogenesis Epilepsia 62 8: 1852-1864. 2021
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Kyyriäinen, Jenni; Kajevu, Natallie; Bañuelos, Ivette; Lara, Leonardo; Lipponen, Anssi; Balosso, Silvia; Hämäläinen, Elina; Das Gupta, Shalini; Puhakka, Noora; Natunen, Teemu; Ravizza, Teresa; Vezzani, Annamaria; Hiltunen, Mikko; Pitkänen, Asla. 2021. Targeting Oxidative Stress with Antioxidant Duotherapy after Experimental Traumatic Brain Injury International journal of molecular sciences 22 19: 10555. 2021
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Hiltunen, Johanna; Ndode-Ekane, Xavier Ekolle; Lipponen, Anssi; Drexel, Meinrad; Sperk, Günther; Puhakka, Noora; Pitkänen, Asla. 2021. Regulation of parvalbumin interactome in the perilesional cortex after experimental traumatic brain injury Neuroscience 475: 52-72. 2021
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Henshall, David C.; Guerrini, Renzo; Jozwiak, Sergiusz; Kokaia, Merab; Pitkanen, Asla; Sisodiya, Sanjay; Simonato, Michele; Cross, J. Helen; Ryvlin, Philippe; Brodie, Martin J.; Trinka, Eugen; Sofia, Francesca. 2021. Meeting report: EpiXchange II brings together European epilepsy research projects to discuss latest advances Epilepsy research 178: 106811. 2021
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Gulcebi, Medine I; Bartolini, Emanuele; Lee, Omay; Lisgaras, Christos Panagiotis; Onat, Filiz; Mifsud, Janet; Striano, Pasquale; Vezzani, Annamaria; Hildebrand, Michael S; Jimenez-Jimenez, Diego; Junck, Larry; Lewis-Smith, David; Scheffer, Ingrid E; Thijs, Roland D; Zuberi, Sameer M; Blenkinsop, Stephen; Fowler, Hayley J; Foley, Aideen; Sisodiya, Sanjay M; Balestrini, Simona et al. [incl. Pitkänen. 2021. Climate change and epilepsy: Insights from clinical and basic science studies Epilepsy and behavior 116: 107791. 2021
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Rajewsky, Nikolaus; Almouzni, Geneviève; Gorski, Stanislaw A; Aerts, Stein; Amit, Ido; Bertero, Michela G; Bock, Christoph; Bredenoord, Annelien L; Cavalli, Giacomo; Chiocca, Susanna; Clevers, Hans; Strooper, Bart De; Eggert, Angelika; Ellenberg, Jan; Fernández, Xosé M; Figlerowicz, Marek; Gasser, Susan M; Hubner, Norbert; Kjems, Jørgen; Knoblich, Jürgen A et al. [incl. Pitkänen, Asla; Leinonen, V. 2020. LifeTime and improving European healthcare through cell-based interceptive medicine Nature 587: 377-386. 2020
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Vuokila, Niina; Gupta, Shalini Das; Huusko, Riina; Tohka, Jussi; Puhakka, Noora; Pitkänen, Asla. 2020. Elevated acute plasma miR-124-3p level relates to evolution of larger cortical lesion area after traumatic brain injury Neuroscience 433: 21-35. 2020
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Vuokila, Niina; Aronica, Eleonora; Korotkov, Anatoly; van Vliet, Erwin Alexander; Nuzhat, Salma; Puhakka, Noora; Pitkänen, Asla. 2020. Chronic Regulation of miR-124-3p in the Perilesional Cortex After Experimental and Human TBI International journal of molecular sciences 21 7: 2418. 2020
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van Vliet, Erwin A; Ndode-Ekane, Xavier Ekolle; Lehto, Lauri J; Gorter, Jan A; Andrade, Pedro; Aronica, Eleonora; Gröhn, Olli; Pitkänen, Asla. 2020. Long-lasting blood-brain barrier dysfunction and neuroinflammation after traumatic brain injury Neurobiology of disease 145: 1-20. 2020
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Ryazantseva, Maria; Englund, Jonas; Shintyapina, Alexandra; Huupponen, Johanna; Shteinikov, Vasilii; Pitkänen, Asla; Partanen, Juha; Lauri, Sari. 2020. Kainate receptors regulate development of glutamatergic synaptic circuitry in the rodent amygdala eLife 9: e52798. 2020
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Kyyriäinen, Jenni; Tapiala, Jesse; Lipponen, Anssi; Ekolle Ndode-Ekane, Xavier; Pitkänen, Asla. 2020. Plau/Plaur double-deficiency did not worsen lesion severity or vascular integrity after traumatic brain injury Neuroscience letters 729: 134935. 2020
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Manninen, Eppu Matias; Chary, Karthik; Lapinlampi, Niina; Andrade, Pedro; Paananen, Tomi; Sierra Lopez, Alejandra; Tohka, Jussi; Gröhn, Olli; Pitkanen, Asla. 2020. Early increase in cortical T2 relaxation is a prognostic biomarker for the evolution of severe cortical damage, but not for epileptogenesis, after experimental traumatic brain injury Journal of neurotrauma 37 23: 2580-2594. 2020
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Lapinlampi, N; Andrade, P; Paananen, T; Hämäläinen, E; Ekolle Ndode-Ekane, X; Puhakka, N; Pitkänen, A. 2020. Postinjury weight rather than cognitive or behavioral impairment predicts development of posttraumatic epilepsy after lateral fluid-percussion injury in rats Epilepsia 61 9: 2035-2052. 2020
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Korotkov, Anatoly; Puhakka, Noora; Gupta, Shalini Das; Vuokila, Niina; Broekaart, Diede W M; Anink, Jasper J; Heiskanen, Mette; Karttunen, Jenni; van Scheppingen, Jackelien; Huitinga, Inge; Mills, James D; van Vliet, Erwin A; Pitkänen, Asla; Aronica, Eleonora. 2020. Increased expression of miR142 and miR155 in glial and immune cells after traumatic brain injury may contribute to neuroinflammation via astrocyte activation Brain pathology 30 5: 897-912. 2020
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Engel, Jerome Jr; Pitkänen, Asla. 2020. Biomarkers For Epileptogenesis And Its Treatment Neuropharmacology 167: 107735. 2020
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Das Gupta, Shalini; Ndode-Ekane, Xavier Ekolle; Puhakka, Noora; Pitkänen, Asla. 2020. Droplet digital polymerase chain reaction-based quantification of circulating microRNAs using small RNA concentration normalization Scientific reports 10: 9012. 2020
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A Computational Diffusion MRI Framework for Biomarker Discovery in a Rodent Model of Post-Traumatic Epileptogenesis. Cabeen, Ryan P; Immonen, Riikka; Harris, Neil G; Gröhn, Olli; Smith, Gregory; Manninen, Eppu; Garner, Rachael; Duncan, Dominique; Pitkänen, Asla; Toga, Arthur W / 2020 IEEE 17th International Symposium on Biomedical Imaging (ISBI). 2020. 2020
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Kyyriäinen, J; Bolkvadze, T; Koivisto, H; Lipponen, A; Pérez, LO; Ekolle Ndode-Ekane, X; Tanila, H; Pitkänen, A. 2019. Deficiency of urokinase-type plasminogen activator and its receptor affects social behavior and increases seizure susceptibility Epilepsy research 151: 67-74. 2019
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Yasmin, Amna; Pitkänen, Asla; Jokivarsi, Kimmo; Poutiainen, Pekka; Gröhn, Olli; Immonen, Riikka. 2019. MRS Reveals Chronic Inflammation in T2w MRI-Negative Perilesional Cortex - A 6-Months Multimodal Imaging Follow-Up Study Frontiers in neuroscience 13: 863. 2019
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Schweser, F; Kyyriäinen, J; Preda, M; Pitkänen, A; Toffolo, K; Poulsen, A; Donahue, K; Levy, B; Poulsen, D. 2019. Visualization of thalamic calcium influx with quantitative susceptibility mapping as a potential imaging biomarker for repeated mild traumatic brain injury Neuroimage 200: 250-258. 2019
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Scharfman, Helen E; Galanopoulou, Aristea S; French, Jacqueline A; Pitkänen, Asla; Whittemore, Vicky; Harte-Hargrove, Lauren C. 2019. Preclinical common data elements (CDEs) for epilepsy: A joint ILAE/AES and NINDS translational initiative Epilepsia open 3: 9-12. 2019
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Santana-Gomez, C; Andrade, P; Hudson, MR; Paananen, T; Ciszek, R; Smith, G; Ali, I; Rundle, BK; Ndode-Ekane, XE; Casillas-Espinosa, PM; Immonen, R; Puhakka, N; Jones, N; Brady, RD; Perucca, P; Shultz, SR; Pitkänen, A; O'Brien, TJ; Staba, R. 2019. Harmonization of pipeline for detection of HFOs in a rat model of post-traumatic epilepsy in preclinical multicenter study on post-traumatic epileptogenesis Epilepsy research 156: 106110. 2019
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Pitkänen, Asla; O'Brien, Terence J; Staba, Richard. 2019. Preface - Practical and theoretical considerations for performing a multi-center preclinical biomarker discovery study of post-traumatic epileptogenesis: lessons learned from the EpiBioS4Rx consortium Epilepsy research 156: 1-4. 2019
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Pitkänen, A; Henshall, DC; Cross, JH; Guerrini, R; Jozwiak, S; Kokaia, M; Simonato, M; Sisodiya, S; Mifsud, J. 2019. Advancing research toward faster diagnosis, better treatment, and end of stigma in epilepsy Epilepsia 60 7: 1281-1292. 2019
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Ndode-Ekane, XE; Santana-Gomez, C; Casillas-Espinosa, PM; Ali, I; Brady, RD; Smith, G; Andrade, P; Immonen, R; Puhakka, N; Hudson, MR; Braine, EL; Shultz, SR; Staba, RJ; O'Brien, TJ; Pitkänen, A. 2019. Harmonization of lateral fluid-percussion injury model production and post-injury monitoring in a preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis Epilepsy research 151: 7-16. 2019
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Lipponen, A; Natunen, T; Hujo, M; Ciszek, R; Hämäläinen, E; Tohka, J; Hiltunen, M; Paananen, J; Poulsen, D; Kansanen, E; Ekolle Ndode-Ekane, X; Levonen, AL; Pitkänen, A. 2019. In Vitro and In Vivo Pipeline for Validation of Disease-Modifying Effects of Systems Biology-Derived Network Treatments for Traumatic Brain Injury - Lessons Learned International journal of molecular sciences 20 21: 5395. 2019
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Pitkänen, Asla; Ekolle, Ndode-Ekane Xavier; Lapinlampi, Niina; Puhakka, Noora. 2019. Epilepsy biomarkers - Toward etiology and pathology specificity Neurobiology of disease 123: 42-58. 2019
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Karttunen, J; Heiskanen, M; Lipponen, A; Poulsen, D; Pitkänen, A. 2019. Extracellular Vesicles as Diagnostics and Therapeutics for Structural Epilepsies International journal of molecular sciences 20 6: 1259. 2019
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Harte-Hargrove, Lauren C; Galanopoulou, Aristea S; French, Jacqueline A; Pitkänen, Asla; Whittemore, Vicky; Scharfman, Helen E. 2019. Common data elements (CDEs) for preclinical epilepsy research: Introduction to CDEs and description of core CDEs. A TASK3 report of the ILAE/AES joint translational task force Epilepsia open 3 S1: 13-23. 2019
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Das Gupta, S; Lipponen, A; Paldanius, KMA; Puhakka, N; Pitkänen, A. 2019. Dynamics of clusterin protein expression in the brain and plasma following experimental traumatic brain injury Scientific reports 9: 20208. 2019
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Andrade, Pedro; Banuelos-Cabrera, Ivette; Lapinlampi, Niina; Paananen, Tomi; Ciszek, Robert; Ndode-Ekane, Xavier Ekolle; Pitkanen, Asla. 2019. Acute non-convulsive status epilepticus after experimental traumatic brain injury in rats Journal of neurotrauma 36 11: 1890-1907. 2019
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Ciszek, R; Andrade, P; Tapiala, J; Pitkänen, A; Ndode-Ekane, XE. 2019. Web Application for Quantification of Traumatic Brain Injury-Induced Cortical Lesions in Adult Mice Neuroinformatics 2020; 18: 307-317. 2019
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Casillas-Espinosa, PM; Andrade, P; Santana-Gomez, C; Paananen, T; Smith, G; Ali, I; Ciszek, R; Ndode-Ekane, XE; Brady, RD; Tohka, J; Hudson, MR; Perucca, P; Braine, EL; Immonen, R; Puhakka, N; Shultz, SR; Jones, NC; Staba, RJ; Pitkänen, A; O'Brien, TJ. 2019. Harmonization of the pipeline for seizure detection to phenotype post-traumatic epilepsy in a preclinical multicenter study on post-traumatic epileptogenesis Epilepsy research 156: 106131. 2019
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Anwer, Mehwish; Lara-Valderrabano, Leonardo; Karttunen, Jenni; Ndode-Ekane, Xavier Ekolle; Puhakka, Noora; Pitkänen, Asla. 2019. Acute downregulation of novel hypothalamic protein sushi repeat-containing protein X-Linked 2 (SRPX2) after experimental traumatic brain injury Journal of neurotrauma 2020; 37 7: 924-938. 2019
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Anwer, M; Immonen, R; Hayward, NMEA; Ndode-Ekane, XE; Puhakka, N; Gröhn, O; Pitkänen, A. 2019. Lateral fluid-percussion injury leads to pituitary atrophy in rats Scientific reports 9 1: 11819. 2019
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Anwer, M; Bolkvadze, T; Puhakka, N; Ndode-Ekane, XE; Pitkänen, A. 2019. Genotype and Injury Effect on the Expression of a Novel Hypothalamic Protein Sushi Repeat-Containing Protein X-Linked 2 (SRPX2) Neuroscience 415: 184-200. 2019
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Immonen, R; Smith, G; Brady, RD; Wright, D; Johnston, L; Harris, NG; Manninen, E; Salo, R; Branch, C; Duncan, D; Cabeen, R; Ndode-Ekane, XE; Gomez, CS; Casillas-Espinosa, PM; Ali, I; Shultz, SR; Andrade, P; Puhakka, N; Staba, RJ; O'Brien, TJ; et al.. 2019. Harmonization of pipeline for preclinical multicenter MRI biomarker discovery in a rat model of post-traumatic epileptogenesis Epilepsy research 150: 46-57. 2019
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Kamnaksh, A; Puhakka, N; Ali, I; Smith, G; Aniceto, R; McCullough, J; Das Gupta, S; Ndode-Ekane, XE; Brady, R; Casillas-Espinosa, P; Hudson, M; Santana-Gomez, C; Immonen, R; Abreu, PA; Jones, N; Shultz, S; Staba, RJ; O'Brien, TJ; Agoston, D; Pitkänen, A. 2018. Harmonization of pipeline for preclinical multicenter plasma protein and miRNA biomarker discovery in a rat model of post-traumatic epileptogenesis EPILEPSY RESEARCH 2019; 149: 92-101. 2018
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Vuokila, Niina; Lukasiuk, Katarzyna; Bot, Anna Maria; van Vliet, Erwin A; Aronica, Eleonora; Pitkänen, Asla; Puhakka Niina. 2018. miR-124-3p is a chronic regulator of gene expression after brain injury Cellular and molecular life sciences 75 24: 4557-4581. 2018
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Tubi, MA; Lutkenhoff, E; Blanco, MB; McArthur, D; Villablanca, P; Ellingson, B; Diaz-Arrastia, R; Van Ness, P; Real, C; Shrestha, V; Engel, J; Jr; Vespa, PM; Agoston, D; Au, A; Bell, MJ; Bleck, T; Branch, C; Buitrago Blanco, M; Bullock, R; Burrows, BT; et al.; EpiBioS4Rx Study Group Investigators (incl. Pitkänen, Asla). 2018. Early seizures and temporal lobe trauma predict post-traumatic epilepsy: A longitudinal study Neurobiology of disease 2019; 123: 115-121. 2018
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Ndode-Ekane, Xavier Ekolle; Matthiesen, Liz; Bañuelos-Cabrera, Ivette; Palminha, Cátia Alexandra Pegas; Pitkänen, Asla. 2018. T-cell infiltration into the perilesional cortex is long-lasting and associates with poor somatomotor recovery after experimental traumatic brain injury RESTORATIVE NEUROLOGY AND NEUROSCIENCE 36 4: 485-501. 2018
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Lipponen, Anssi; El-Osta, Assam; Kaspi, Antony; Ziemann, Mark; Khurana, Ishant; Harikrishnan, K N; Navarro-Ferrandis, Vicente; Puhakka, Noora; Paananen, Jussi; Pitkänen, Asla. 2018. Transcription factors Tp73, Cebpd, Pax6, and Spi1 rather than DNA methylation regulate chronic transcriptomics changes after experimental traumatic brain injury. Acta neuropathologica communications 6: 17. 2018
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Karttunen, Jenni; Heiskanen, Mette; Navarro-Ferrandis, Vicente; Das Gupta, Shalini; Lipponen, Anssi; Puhakka, Noora; Rilla, Kirsi; Koistinen, Arto; Pitkänen, Asla. 2018. Precipitation-based extracellular vesicle isolation from rat plasma co-precipitate vesicle-free microRNAs Journal of Extracellular Vesicles 2019; 8 1: 1555410. 2018
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Rauramaa, T; Saxlin, A; Lohvansuu, K; Alafuzoff, I; Pitkänen, A; Soininen, H. 2018. Epilepsy in neuropathologically verified Alzheimer's disease. SEIZURE 58: 9-12. 2018
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Huttunen, JK; Airaksinen, AM; Barba, C; Colicchio, G; Niskanen, JP; Shatillo, A; Sierra Lopez, A; Ndode-Ekane, XE; Pitkanen, A; Gröhn, O. 2018. Detection of Hyperexcitability by fMRI After Experimental Traumatic Brain Injury Journal of neurotrauma 35 22: 2708-2717. 2018
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Duncan, Dominique; Barisano, Giuseppe; Cabeen, Ryan; Sepehrband, Farshid; Garner, Rachael; Braimah, Adebayo; Vespa, Paul; Pitkänen, Asla; Law, Meng; Toga, Arthur W. 2018. Analytic Tools for Post-traumatic Epileptogenesis Biomarker Search in Multimodal Dataset of an Animal Model and Human Patients Frontiers in Neuroscience 12: 86. 2018
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Ciszek, R; Ndode-Ekane, XE; Gomez, CS; Casillas-Espinosa, PM; Ali, I; Smith, G; Puhakka, N; Lapinlampi, N; Andrade, P; Kamnaksh, A; Immonen, R; Paananen, T; Hudson, MR; Brady, RD; Shultz, SR; O'Brien, TJ; Staba, RJ; Tohka, J; Pitkänen, A. 2018. Informatics tools to assess the success of procedural harmonization in preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis EPILEPSY RESEARCH 2019; 150: 17-26. 2018
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Anwer, M; Bolkvadze, T; Ndode-Ekane, XE; Puhakka, N; Rauramaa, T; Leinonen, V; van Vliet, EA; Swaab, DF; Haapasalo, A; Leskelä, S; Bister, N; Malm, T; Carlson, S; Aronica, E; Pitkänen, A. 2018. Sushi repeat-containing protein X-Linked 2 - a novel phylogenetically conserved hypothalamo-pituitary protein JOURNAL OF COMPARATIVE NEUROLOGY 526 11: 1806-1819. 2018
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Andrade, Pedro; Paananen, Tomi; Ciszek, Robert; Lapinlampi, Niina; Pitkänen, Asla. 2018. Algorithm for automatic detection of spontaneous seizures in rats with post-traumatic epilepsy JOURNAL OF NEUROSCIENCE METHODS 307: 37-45. 2018
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Andrade, Pedro; Ciszek, Robert; Pitkänen, Asla; Ndode-Ekane, Xavier Ekolle. 2018. A web-based application for generating 2D-unfolded cortical maps to analyze the location and extent of cortical lesions following traumatic brain injury in adult rats JOURNAL OF NEUROSCIENCE METHODS 308: 330-336. 2018
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Duncan, Dominique; Vespa, Paul; Pitkanen, Asla; Braimah, Adebayo; Lapinlampi, Niina; Toga, Arthur W. 2018. Big data sharing and analysis to advance research in post-traumatic epilepsy Neurobiology of disease 2019; 123: 127-136. 2018
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Nissinen J, Andrade P, Natunen T, Hiltunen M, Malm T, Kanninen K, Soares JI, Shatilloa O, Sallinen J, Ndode-Ekanea XE, Pitkänen A. 2017. Disease-modifying effect of atipamezole in a model of post-traumatic epilepsy. EPILEPSY RESEARCH 136: 18-34. 2017
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van Vliet Erwin A, Puhakka Noora, Mills James D, Srivastava Prashant K, Johnson Michael R, Roncon Paolo, Das Gupta Shalini, Karttunen Jenni, Simonato Michele, Lukasiuk Katarzyna, Gorter Jan A, Aronica Eleonora, Pitkänen Asla. 2017. Standardization procedure for plasma biomarker analysis in rat models of epileptogenesis: Focus on circulating microRNAs. EPILEPSIA (NY) 58 12: 2013-2024. 2017
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Tanila H, Pitkänen A. 2017. Epilepsy in Models of Alzheimer's Disease. Teoksessa: Pitkänen A, Buckmaster PS, Galanopoulou AS, Moshé SL (toim.) Models of Seizures and Epilepsy (Second Edition). Elsevier. s. 1021-1030. 2017
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Srivastava, Prashant K; Roncon, Paolo; Lukasiuk, Katarzyna; Gorter, Jan A; Aronica, Eleonora; Pitkänen, Asla; Petretto, Enrico; Johnson, Michael R; Simonato, Michele. 2017. Meta-Analysis of MicroRNAs Dysregulated in the Hippocampal Dentate Gyrus of Animal Models of Epilepsy. eNeuro 4 6: 1-22. 2017
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Puhakka Noora, Bot Anna Maria, Vuokila Niina, Debski Konrad Jozef, Lukasiuk Katarzyna, Pitkänen Asla. 2017. Chronically dysregulated NOTCH1 interactome in the dentate gyrus after traumatic brain injury. PLOS ONE 12 3: e0172521. 2017
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Pitkänen Asla, Kyyriäinen Jenni, Andrade Pedro, Pasanen Lotta, Ndode-Ekane Xavier Ekolle. 2017. Epilepsy After Traumatic Brain Injury. Teoksessa: Pitkänen Asla, Buckmaster Paul S, Galanopoulou Aristea S, Moshé Solomon L (toim.) Models of Seizures and Epilepsy (Second Edition). Elsevier. s. 661-681. 2017
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Pitkänen A, Galanopoulou AS, Moshé SL, Buckmaster PS. 2017. What Can We Model?. Teoksessa: Pitkänen A, Buckmaster PS, Galanopoulou AS, Moshé SL (toim.) Models of Seizures and Epilepsy (Second Edition). Elsevier. s. 1-3. 2017
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Models of Seizures and Epilepsy (Second Edition). Pitkänen A, Buckmaster PS, Galanopoulou AS, Moshé SL. 2017 2017
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Ndode-Ekane Xavier Ekolle, Kharatishvili Irina, Pitkänen Asla. 2017. Unfolded Maps for Quantitative Analysis of Cortical Lesion Location and Extent after Traumatic Brain Injury. JOURNAL OF NEUROTRAUMA (NEW YORK NY) 34 2: 459-474. 2017
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Missault S, Peeters L, Amhaoul H, Thomae D, Van Eetveldt A, Favier B, Thakur A, Van Soom J, Pitkänen A, Augustyns K, Joossens J, Staelens S, Dedeurwaerdere S. 2017. Decreased levels of active uPA and KLK8 assessed by [111In]MICA-401 binding correlate with the seizure burden in an animal model of temporal lobe epilepsy. EPILEPSIA (NY) 58 9: 1615-1625. 2017
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Klein P, Dingledine R, Aronica E, Bernard C, Blümcke I, Boison D, Brodie MJ, Brooks-Kayal AR, Engel J Jr, Forcelli PA, Hirsch LJ, Kaminski RM, Klitgaard H, Kobow K, Lowenstein DH, Pearl PL, Pitkänen A, Puhakka N, Rogawski MA, Schmidt D et al.. 2017. Commonalities in epileptogenic processes from different acute brain insults: Do they translate?. EPILEPSIA (NY) 2018; 59 1: 37-66. 2017
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Harte-Hargrove LC, French JA, Pitkänen A, Galanopoulou AS, Whittemore V, Scharfman HE. 2017. Common data elements for preclinical epilepsy research: Standards for data collection and reporting. A TASK3 report of the AES/ILAE Translational Task Force of the ILAE. EPILEPSIA (NY) 58 Suppl 4: 78-86. 2017
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Galanopoulou AS, Pitkänen A, Buckmaster PS, Moshé SL. 2017. What Do Models Model? What Needs to Be Modeled?. Teoksessa: Pitkänen A, Buckmaster PS, Galanopoulou AS, Moshé SL (toim.) Models of Seizures and Epilepsy (Second Edition). Elsevier. s. 1107-1119. 2017
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Dingledine Raymond, Coulter Douglas A, Fritsch Brita, Gorter Jan A, Lelutiu Nadia, McNamara James, Nadler J Victor, Pitkänen Asla, Rogawski Michael A, Skene Pate, Sloviter Robert S, Wang Yu, Wadman Wytse J, Wasterlain Claude, Roopra Avtar. 2017. Transcriptional profile of hippocampal dentate granule cells in four rat epilepsy models. Scientific Data 4 -: 1-10. 2017
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Andrade Pedro, Nissinen Jari, Pitkanen Asla. 2017. Generalized Seizures after Experimental Traumatic Brain Injury Occur at the Transition from Slow-Wave to Rapid-Eye-Movement Sleep. JOURNAL OF NEUROTRAUMA (NEW YORK NY) 34 7: 1482-1487. 2017
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Pirttimäki T, Salo RA, Shatillo A, Kettunen MI, Paasonen J, Sierra A, Jokivarsi K, Leinonen V, Andrade P, Quittek S, Pitkänen A, Gröhn O. 2016. Implantable RF-coil with multiple electrodes for long-term EEG-fMRI monitoring in rodents. JOURNAL OF NEUROSCIENCE METHODS 274: 154-163. 2016
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Ziyatdinova Sofya, Rönnbäck Annica, Gurevicius Kestutis, Miszczuk Diana, Graff Caroline, Winblad Bengt, Pitkänen Asla, Tanila Heikki. 2016. Increased Epileptiform EEG Activity and Decreased Seizure Threshold in Arctic APP Transgenic Mouse Model of Alzheimer's Disease. CURRENT ALZHEIMER RESEARCH 13 7: 817-830. 2016
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van Vliet EA, Dedeurwaerdere S, Cole AJ, Friedman A, Koepp MJ, Potschka H, Immonen R, Pitkänen A, Federico P. 2016. WONOEP appraisal: Imaging biomarkers in epilepsy. EPILEPSIA (NY) 58 3: 315-330. 2016
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Pitkänen A, Löscher W, Vezzani A, Becker AJ, Simonato M, Lukasiuk K, Gröhn O, Bankstahl JP, Friedman A, Aronica E, Gorter JA, Ravizza T, Sisodiya SM, Kokaia M, Beck H. 2016. Advances in the development of biomarkers for epilepsy. LANCET NEUROLOGY 15 8: 843-856. 2016
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Lapinlampi N, Melin E, Aronica E, Bankstahl JP, Becker A, Bernard C, Gorter JA, Gröhn O, Lipsanen A, Lukasiuk K, Löscher W, Paananen J, Ravizza T, Roncon P, Simonato M, Vezzani A, Kokaia M, Pitkänen A. 2016. Common data elements and data management: Remedy to cure underpowered preclinical studies. EPILEPSY RESEARCH 129 January 2017: 87-90. 2016
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López-Picón F, Snellman A, Shatillo O, Lehtiniemi P, Grönroos TJ, Marjamäki P, Trigg W, Jones PA, Solin O, Pitkänen A, Haaparanta-Solin M. 2016. Ex Vivo Tracing of NMDA and GABA-A Receptors in Rat Brain After Traumatic Brain Injury Using 18F-GE-179 and 18F-GE-194 Autoradiography. JOURNAL OF NUCLEAR MEDICINE 57 9: 1442-1447. 2016
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Bolkvadze T, Puhakka N, Pitkänen A. 2016. Epileptogenesis after traumatic brain injury in Plaur-deficient mice. EPILEPSY & BEHAVIOR 60 July 2016: 187-196. 2016
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Kyyriäinen Jenni, Ndode-Ekane Xavier Ekkolle, Pitkänen Asla. 2016. Dynamics of PDGFRß Expression in Different Cell Types After Brain Injury. GLIA 2017; 65 2 (February 2017): 322-341. 2016
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Debski KJ, Pitkanen A, Puhakka N, Bot AM, Khurana I, Harikrishnan KN, Ziemann M, Kaspi A, El-Osta A, Lukasiuk K, Kobow K. 2016. Etiology matters - Genomic DNA methylation patterns in three rat models of acquired epilepsy. Scientific Reports 6: 25668. 2016
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Lipponen Anssi, Paananen Jussi, Puhakka Noora, Pitkänen Asla. 2016. Analysis of Post-Traumatic Brain Injury Gene Expression Signature Reveals Tubulins, Nfe2l2, Nfkb, Cd44, and S100a4 as Treatment Targets. Scientific Reports 6: 31570. 2016
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Pitkänen Asla, Lukasiuk Katarzyna, Dudek F Edward, Staley Kevin J. 2015. Epileptogenesis. Cold Spring Harbor Perspectives in Medicine [epub ahead of print Sep 18, 2015]: a022822. 2015
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Ziyatdinova Sofya, Viswanathan Jayashree, Hiltunen Mikko, Tanila Heikki, Pitkänen Asla. 2015. Reduction of epileptiform activity by valproic acid in a mouse model of Alzheimer's disease is not long-lasting after treatment discontinuation. EPILEPSY RESEARCH 112: 43-55. 2015
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Sierra A, Gröhn O, Pitkänen A. 2015. Imaging microstructural damage and plasticity in the hippocampus during epileptogenesis. NEUROSCIENCE 309: 162-172. 2015
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Rantala J, Kemppainen S, Ndode-Ekane XE, Lahtinen V, Bolkvadze Tamuna, Gurevicius K, Tanila H, Pitkänen A. 2015. Urokinase-type plasminogen activator deficiency has little effect on seizure susceptibility and acquired epilepsy phenotype but reduces spontaneous exploration in mice. EPILEPSY & BEHAVIOR 42: 117-128. 2015
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Pitkänen Asla, Roivainen Reina, Luasiuk Katarzyna. 2015. Development of epilepsy after ischaemic stroke. LANCET NEUROLOGY 2016; 15 2: 185-197. 2015
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Miszczuk Diana, Debski Konrad J, Tanila Heikki, Lukasiuk Katarzyna, Pitkänen Asla. 2015. Traumatic Brain Injury Increases the Expression of Nos1, Aß Clearance, and Epileptogenesis in APP/PS1 Mouse Model of Alzheimer's Disease. MOLECULAR NEUROBIOLOGY 2016; 53 10: 7010-7027. 2015
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Lidster K, Jefferys JG, Blümcke I, Crunelli V, Flecknell P, Frenguelli BG, Gray WP, Kaminski R, Pitkänen A, Ragan I, Shah M, Simonato M, Trevelyan A, Volk H, Walker M, Yates N, Prescott MJ. 2015. Opportunities for improving animal welfare in rodent models of epilepsy and seizures. JOURNAL OF NEUROSCIENCE METHODS 2016; 260: 2-25. 2015
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Laitinen Teemu, Sierra Alejandra, Bolkvadze Tamuna, Pitkänen Asla, Gröhn Olli. 2015. Diffusion tensor imaging detects chronic microstructural changes in white and gray matter after traumatic brain injury in rat. Frontiers in Neuroscience 9 Article 128: 12 p. 2015
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Kyyriäinen J., Ndode-Ekane X. E., Pitkänen A.. 2015. Expression of PDGFR-beta positive NG2 cells in the hippocampus after status epilepticus.Wiley. E142-E143. 2015
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Engel Jerome Jr, Pitkänen Asla. 2015. Epilepsy biomarkers. Teoksessa: Shorvon Simon D, Perucca Emilio, Engel Jerome Jr. (Eds.) (toim.) Treatment of Epilepsy (4th Edition). WILEY-BLACKWELL. s. 103-109. 2015
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Bolkvadze Tamuna, Rantala Jukka, Puhakka Noora, Andrade Petro, Pitkänen Asla. 2015. Epileptogenesis after traumatic brain injury in Plau-deficient mice. EPILEPSY & BEHAVIOR 51: 19-27. 2015
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Baulac Michel, de Boer Hanneke, Elger Christian, Glynn Mike, Kälviäinen Reetta, Little Ann, Mifsud Janet, Perucca Emilio, Pitkänen Asla, Ryvlin Philippe. 2015. Epilepsy priorities in Europe: A report of the ILAE-IBE Epilepsy Advocacy Europe Task Force. EPILEPSIA (NY) [epub ahead of print 28 SEP 2015]: -. 2015
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Pitkänen A, Ndode-Ekane XE, Lukasiuk K, Wilczynski GM, Dityatev A, Walker MC, Chabrol E, Dedeurwaerdere S, Vazquez N, Powell EM. 2014. Neural ECM and epilepsy. PROGRESS IN BRAIN RESEARCH (AMSTERDAM) 214: 229-62. 2014
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Simonato Michele, Brooks-Kayal Amy R, Engel Jr Jerome, Galanopoulou Aristea S, Jensen Frances E, Moshé Solomon L, O'Brien Terence J, Pitkanen Asla, Wilcox Karen S, French Jacqueline A. 2014. The challenge and promise of anti-epileptic therapy development in animal models. LANCET NEUROLOGY 13 9: 949-60. 2014
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Rosenow F, Alonso-Vanegas MA, Baumgartner C, Blümcke I, Carreño M, Gizewski ER, Hamer HM, Knake S, Kahane P, Lüders HO, Mathern GW, Menzler K, Miller J, Otsuki T, Ozkara C, Pitkänen A, Roper SN, Sakamoto AC, Sure U, Walker MC, Steinhoff BJ; Surgical Task Force, Commission on Therapeutic Strategies of the ILAE. 2014. In response to commentary on cavernoma-related epilepsy: review and recommendations for management-report of the surgical task force of the ILAE commission on therapeutic strategies. EPILEPSIA (NY) 55 3: 466-467. 2014
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Powell Kim L, Lukasiuk Katarzyna, O'Brien Terence J, Pitkänen Asla. 2014. Are Alterations in Transmitter Receptor and Ion Channel Expression Responsible for Epilepsies?: Helen E. Scharfman, Paul S. Buckmaster, Issues in Clinical Epileptology: A View from the Bench. Advances in Experimental Medicine and Biology 813. 211-29. 2014
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Pitkänen Asla, Kemppainen Samuli, Ndode-Ekane Xavier Ekolle, Huusko Noora, Huttunen Joanna K, Gröhn Olli, Immonen Riikka, Sierra Alejandra, Bolkvadze Tamuna. 2014. Posttraumatic epilepsy - Disease or comorbidity?. EPILEPSY & BEHAVIOR 2014 Feb 11. [Epub ahead of print]: --. 2014
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Pitkänen Asla, Immonen Riitta. 2014. Epilepsy related to traumatic brain injury. NEUROTHERAPEUTICS 11 2: 286-296. 2014
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Brain Extracellular Matrix in Health and Disease. Dityatev A, Wehrle-Haller B, Pitkänen A. 2014 2014
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Pitkänen A, Immonen R, Ndode-Ekane X, Gröhn O, Stöhr T, Nissinen J. 2014. Effect of lacosamide on structural damage and functional recovery after traumatic brain injury in rats. EPILEPSY RESEARCH 2014 May;108(4): 653-65. 2014
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Pitkänen A, Huusko N, Ndode-Ekane XE, Kyyriäinen J, Lipponen A, Lipsanen A, Sierra A, Bolkvadze T. 2014. Gender issues in antiepileptogenic treatments. NEUROBIOLOGY OF DISEASE (SAN DIEGO CA) 2014 Jun 6 ePub ahead of print: pii: S0969-9961(14)00163-6. 2014
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Pitkänen A, Engel J Jr. 2014. Past and Present Definitions of Epileptogenesis and Its Biomarkers. NEUROTHERAPEUTICS 2014 Apr;11(2): 231-41. 2014
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Mishra Asht Mangal, Bai Xiaoxiao, Sanganahalli Basavaraju G, Waxman Stephen G, Shatillo Olena, Gröhn Olli, Hyder Fahmeed, Pitkänen Asla, Blumenfeld Hal. 2014. Decreased resting functional connectivity after traumatic brain injury in the rat. PLOS ONE [ONLINE] 2014 Apr 18;9(4): e95280. 2014
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Menzler K, Hermsen A, Balkenhol K, Duddek C, Bugiel H, Bauer S, Schorge S, Reif PS, Klein KM, Haag A, Oertel WH, Hamer HM, Knake S, Trucks H, Sander T, Rosenow F; EPICURE-Consortium. 2014. A common SCN1A splice-site polymorphism modifies the effect of carbamazepine on cortical excitability--a pharmacogenetic transcranial magnetic stimulation study. EPILEPSIA (NY) 2014 Feb;55(2): 362-9. 2014
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Huusko N, Pitkänen A. 2014. Parvalbumin immunoreactivity and expression of GABAA receptor subunits in the thalamus after experimental TBI. NEUROSCIENCE 2014 May 16;267: 30-45.. 2014
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Drexel M, Puhakka N, Kirchmair E, Hörtnagl H, Pitkänen A, Sperk G. 2014. Expression of GABA receptor subunits in the hippocampus and thalamus after experimental traumatic brain injury. NEUROPHARMACOLOGY 2014 Sep 16: pii: S0028-3908(14)00306-2. 2014
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Sierra A, Laitinen T, Gröhn O, Pitkänen A. 2013. Diffusion tensor imaging of hippocampal network plasticity. Brain structure & function 220 2: 781-801. 2013
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Rosenow F, Alonso-Vanegas MA, Baumgartner C, Blümcke I, Carreño M, Gizewski ER, Hamer HM, Knake S, Kahane P, Lüders HO, Mathern GW, Menzler K, Miller J, Otsuki T, Ozkara C, Pitkänen A, Roper SN, Sakamoto AC, Sure U, Walker MC, Steinhoff BJ; Surgical Task Force, Commission on Therapeutic Strategies of the ILAE. 2013. Cavernoma-related epilepsy: Review and recommendations for management-Report of the Surgical Task Force of the ILAE Commission on Therapeutic Strategies. EPILEPSIA (NY) 2013 Dec;54(12):: 2025-35.. 2013
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Niskanen JP, Airaksinen AM, Sierra A, Huttunen JK, Nissinen J, Karjalainen PA, Pitkänen A, Gröhn OH. 2013. Monitoring functional impairment and recovery after traumatic brain injury in rats by FMRI. JOURNAL OF NEUROTRAUMA (NEW YORK NY) 2013 Apr 1;30(7): 546-56. 2013
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Pitkänen A, Nehlig A, Brooks-Kayal AR, Dudek FE, Friedman D, Galanopoulou AS, Jensen FE, Kaminski RM, Kapur J, Klitgaard H, Löscher W, Mody I, Schmidt D. 2013. Issues related to development of antiepileptogenic therapies. EPILEPSIA (NY) 2013 Aug;54 Suppl 4:: 35-43. 2013
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Pitkänen Asla. 2013. Targets for antiepileptogenesis: Overview: Potschka H and Lerche H (eds.), Therapeutic targets and perspectives in the pharmacological treatment of epilepsy. 86-90. 2013
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Immonen R, Kharatishvili I, Gröhn O, Pitkänen A. 2013. MRI biomarkers for post-traumatic epileptogenesis.. JOURNAL OF NEUROTRAUMA (NEW YORK NY) 2013 Jul 15;30(14): 1305-9. 2013
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Huusko N, Römer C, Ndode-Ekane XE, Lukasiuk K, Pitkänen A. 2013. Loss of hippocampal interneurons and epileptogenesis: a comparison of two animal models of acquired epilepsy. Brain structure & function 2015; 220 1: 153-191. 2013
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Galanopoulou AS, Kokaia M, Loeb JA, Nehlig A, Pitkänen A, Rogawski MA, Staley KJ, Whittemore VH, Edward Dudek F. 2013. Epilepsy therapy development: Technical and methodologic issues in studies with animal models. EPILEPSIA (NY) 2013 Aug;54 Suppl 4: 13-23. 2013
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Epilepsy Advocacy Europe, Sheanon E, Pitkänen A. 2013. Epilepsy on the horizon. EPILEPSIA (NY) 54: 1713-4. 2013
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Engel J Jr, Pitkänen A, Loeb JA, Dudek FE, Bertram EH 3rd, Cole AJ, Moshé SL, Wiebe S, Jensen FE, Mody I, Nehlig A, Vezzani A. 2013. Epilepsy biomarkers. EPILEPSIA (NY) 2013 Aug;54 Suppl 4: 61-69. 2013
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Zilberter M, Ivanov A, Ziyatdinova S, Mukhtarov M, Malkov A, Alpár A, Tortoriello G, Botting CH, Fülöp L, Osypov AA, Pitkänen A, Tanila H, Harkany T, Zilberter Y. 2012. Dietary energy substrates reverse early neuronal hyperactivity in a mouse model of Alzheimer's disease. JOURNAL OF NEUROCHEMISTRY 2012 Dec 14.[Epub ahead of print]: --. 2012
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Pitkänen Asla, Bolkvadze Tamuna. 2012. Head Trauma and Epilepsy: Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th edition. 331-342. 2012
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Ndode-Ekane XE, Pitkänen A. 2012. Urokinase-Type Plasminogen Activator Receptor Modulates Epileptogenesis in Mouse Model of Temporal Lobe Epilepsy. MOLECULAR NEUROBIOLOGY 2012 Dec 21. [Epub ahead of print]: --. 2012
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Lukasiuk K, Pitkänen A. 2012. Molecular Basis of Acquired Epileptogenesis: Stefan H, Theodore W, Handbook of clinical neurology: Epilepsy Part I: Basic Principles and Diagnosis. Handbook of Clinical Neurology Volume 107: Epilepsy Part I. 3-12. 2012
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Kubova H, Lukasiuk K, Pitkänen A. 2012. New Insight on the Mechanisms of Epileptogenesis in the Developing Brain: Akalan Nejat, Di Rocco Concezio, Pediatric Epilepsy Surgery. Advances and Technical Standards in Neurosurgery Vol. 39. --. 2012
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Lehto LJ, Sierra A, Corum CA, Zhang J, Idiyatullin D, Pitkänen A, Garwood M, Gröhn O. 2012. Detection of Calcifications In Vivo and Ex Vivo after Brain Injury in Rat Using SWIFT. NEUROIMAGE 2012 Jul 16;61(4): 761-72. 2012
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Kobow K, Auvin S, Jensen F, Löscher W, Mody I, Potschka H, Prince D, Sierra A, Simonato M, Pitkänen A, Nehlig A, Rho JM. 2012. Finding a better drug for epilepsy: Antiepileptogenesis targets. EPILEPSIA (NY) 2012 Nov;53(11): 1868-1876. 2012
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Galanopoulou AS, Buckmaster PS, Staley KJ, Moshé SL, Perucca E, Engel J Jr, Löscher W, Noebels JL, Pitkänen A, Stables J, White HS, O'Brien TJ, Simonato M. 2012. Identification of new epilepsy treatments: issues in preclinical methodology. EPILEPSIA (NY) 2012 Mar;53(3): 571-82. 2012
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Baulac M, De Boer H, Elger C, Glynn M, Kälviäinen R, Little A, Mifsud J, Perucca E, Pitkänen A. 2012. The Written Declaration on Epilepsy: An important achievement for Europe and beyond SEIZURE 21: 75-76. 2012
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Airaksinen AM, Hekmatyar SK, Jerome N, Niskanen JP, Huttunen JK, Pitkänen A, Kauppinen RA, Gröhn OH. 2012. Simultaneous BOLD fMRI and local field potential measurements during kainic acid-induced seizures. EPILEPSIA (NY) 2012 Jul;53(7): 1245-53. 2012
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Ziyatdinova Sofya, Gurevicius Kestutis, Kutchiashvili Nino, Bolkvadze Tamuna, Nissinen Jari, Tanila Heikki, Pitkänen Asla. 2011. Spontaneous epileptiform discharges in a mouse model of Alzheimer's disease are suppressed by antiepileptic drugs that block sodium channels. EPILEPSY RESEARCH 94: 75-85. 2011
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Sierra Alejandra, Laitinen Teemu, Lehtimäki Kimmo, Rieppo Lassi, Pitkänen Asla, Gröhn Olli. 2011. Diffusion tensor MRI with tract-based spatial statistics and histology reveals undiscovered lesioned areas in kainate model of epilepsy in rat. Brain Structure and Function 216: 123-135. 2011
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Pitkänen Asla, Lukasiuk Katarzyna. 2011. Mechanisms of epileptogenesis and potential treatment targets. LANCET NEUROLOGY 10: 173-186. 2011
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Pitkänen Asla, Bolkvadze Tamuna, Immonen Riikka. 2011. Anti-epileptogenesis in rodent post-traumatic epilepsy models NEUROSCIENCE LETTERS 497: 163-171. 2011
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Pitkänen A, Lukasiuk K. 2011. Molecular biomarkers of epileptogenesis Biomarkers in Medicine 5 5: 629-33. 2011
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Pavlov I,Huusko N,Drexel M,Kirchmair E,Sperk G,Pitkänen A,Walker MC. 2011. Progressive loss of phasic, but not tonic, GABAA receptor-mediated inhibition in dentate granule cells in a model of post-traumatic epilepsy in rats NEUROSCIENCE 194: 208-219. 2011
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Hayward Nick Mark Edward Alexander, Tuunanen Pasi, Immonen Riikka, Ndode-Ekane Xavier Ekolle, Pitkänen Asla, Gröhn Olli. 2011. Magnetic resonance imaging of regional hemodynamic and cerebrovascular recovery after lateral fluid-percussion brain injury in rats. Journal of Cerebral Blood Flow & Metabolism 31: 166-177. 2011
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Gröhn O, Sierra A, Immonen R, Laitinen T, Lehtimäki K, Airaksinen A, Hayward N, Nairismagi J, Lehto L, Pitkänen A. 2011. Multimodal MRI assessment of damage and plasticity caused by status epilepticus in the rat brain EPILEPSIA (NY) 52(Suppl. 8): 57-60. 2011
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Bolkvadze T, Pitkänen A. 2011. Development of Post-Traumatic Epilepsy after Controlled Cortical Impact and Lateral Fluid-Percussion-Induced Brain Injury in the Mouse. JOURNAL OF NEUROTRAUMA (NEW YORK NY) 2012:29(5) 2012 Jan 4. [Epub ahead of print]: 789-812. 2011
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Pitkänen A. 2010. Therapeutic approaches to epileptogenesis - hope on the horizon EPILEPSIA. SUPPLEMENT 3: 2-17. 2010
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Pitkänen A & Bolkvadze T. 2010. Epileptogenesis after traumatic brain injury. Teoksessa: (toim.), Atlas of Epilepsies. ss. 335-341. 2010
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Ndode-Ekane XE, Hayward N, Gröhn O & Pitkänen A. 2010. Vascular changes in epilepsy: functional consequences and association with network plasticity in pilocarpine-induced experimental epilepsy. NEUROSCIENCE 166: 312-332. 2010
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Laitinen T, Sierra A, Pitkänen A & Gröhn O. 2010. Diffusion tensor MRI of axonal plasticity in the rat hippocampus. NEUROIMAGE 51: 251-530. 2010
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Lahtinen L, Ndode-Ekane XE, Barinka F, Akamine Y, Esmaeili MH, Rantala J & Pitkänen A. 2010. Urokinase-type plasminogen activator regulates neurodegeneration and neurogenesis but not vascular changes in the mouse hippocampus after status epilepticus NEUROBIOLOGY OF DISEASE (SAN DIEGO CA) 37: 692-703. 2010
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Kharatishvili I & Pitkänen A. 2010. Posttraumatic epilepsy. CURRENT OPINION IN NEUROLOGY (PHILADELPHIA PA) 23 2: 183-188. 2010
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Kharatishvili I & Pitkänen A. 2010. Association of the severity of cortical damage with the occurrence of spontaneous seizures and hyperexcitability in an animal model of posttraumatic epilepsy. EPILEPSY RESEARCH 90: 47-59. 2010
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Hayward NM, Ndode-Ekane XE, Kutchiashvili N, Gröhn O Pitkänen A.. 2010. Elevated cerebral blood flow and vascular density in the amygdala after status epilepticus in rats. NEUROSCIENCE LETTERS 484: 39-42. 2010
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Hayward NM, Immonen R, Tuunanen PI, Ndode-Ekane XE, Gröhn O & Pitkänen A. 2010. Association of chronic vascular changes with functional outcome after traumatic brain injury in rats JOURNAL OF NEUROTRAUMA (NEW YORK NY) 27: 2203-2219. 2010
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Airaksinen AM, Niskanen JP, Chamberlain R, Huttunen JK, Nissinen J, Garwood M, Pitkänen A & Gröhn O. 2010. Simultaneous fMRI and local field potential measurements during epileptic seizures in medetomidine-sedated rats using raser pulse sequence MAGNETIC RESONANCE IN MEDICINE 64: 1191-1199. 2010
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Pitkänen A, Lukasiuk K. 2009. Seizure-induced gene expression: Schwartzkroin PA, Encyclopedia of Basic Epilepsy Research.Academic Press. 1302-1309. 2009
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Pitkänen A, Lukasiuk K. 2009. Molecular and cellular basis of epileptogenesis in symptomatic epilepsy. EPILEPSY & BEHAVIOR 14: 16-25. 2009
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Pitkänen A, Lukasiuk K. 2009. Epilepsy: Neuronal Death: Squire LR, Enclyclopedia of Neuroscience. Vol. 3.Academid Press. 1159-1166. 2009
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Pitkänen A, Immonen RJ, Gröhn OH, Kharatishvili I. 2009. From traumatic brain injury to posttraumatic epilepsy: what animal models tell us about the process and treatment options. EPILEPSIA. SUPPLEMENT 50 2: 21-29. 2009
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Marklund N, Morales D, Clausen F, Hånell A, Kiwanuka O, Pitkänen A, Gimbel DA, Philipson O, Lannfelt L, Hillered L, Strittmatter SM, McIntosh TK. 2009. Functional outcome is impaired following traumatic brain injury in aging Nogo-A/B-deficient mice. NEUROSCIENCE 163: 540-551. 2009
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Minkeviciene R, Rheims S, Dobszay MB, Zilberter M, Hartikainen J, Fülöp L, Penke B, Zilberter Y, Harkany T, Pitkänen A, Tanila H. 2009. Amyloid beta-induced neuronal hyperexcitability triggers progressive epilepsy. JOURNAL OF NEUROSCIENCE 29 11: 3453-3462. 2009
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Noé F, Frasca A, Balducci C, Carli M, Sperk G, Ferraguti F, Pitkänen A, Bland R, Fitzsimons H, During M, Vezzani A. 2009. Neuropeptide Y overexpression using recombinant adeno-associated viral vectors. NEUROTHERAPEUTICS 6: 300-306. 2009
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Majak K, Dabrowski M, Pitkänen A. 2009. Epileptogenesis alters gene expression pattern in rats subjected to amygdala-dependent emotional learning. NEUROSCIENCE 159: 468-482. 2009
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Lahtinen L, Huusko N, Myöhänen H, Lehtivarjo AK, Pellinen R, Turunen MP, Ylä-Herttuala S, Pirinen E, Pitkänen A. 2009. Expression of urokinase-type plasminogen activator receptor is increased during epileptogenesis in the rat hippocampus. NEUROSCIENCE 163: 316-328. 2009
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Kriegstein AR, Pitkänen A. 2009. Commentary: the prospect of cell-based therapy for epilepsy NEUROTHERAPEUTICS 6: 295-299. 2009
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Kharatishvili I, Sierra A, Immonen RJ, Gröhn OHJ, Pitkänen A. 2009. Quantitative T2 mapping as a potential marker for the initial assessment of the severity of damage after traumatic brain injury in rat. EXPERIMENTAL NEUROLOGY 217: 154-164. 2009
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Kharatishvili I, Pitkänen A. 2009. Posttraumatic models: Schwartzkroin PA, Encyclopedia of Basic Epilepsy Research. Vol. 3.Academic Preess. 1229-1238. 2009
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Immonen RJ, Kharatishvili I, Niskanen J-P, Gröhn H, Pitkänen A, Gröhn OHJ. 2009. Distinct MRI pattern in lesional and perilesional area after traumatic brain injury in rat - 11 months follow-up. EXPERIMENTAL NEUROLOGY 215: 29-40. 2009
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Immonen RJ, Kharatishvili I, Gröhn H, Pitkänen A, Gröhn OHJ. 2009. Quantitative MRI predicts long-term structural and functional outcome after experimental traumatic brain injury NEUROIMAGE 45: 1-9. 2009
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Maja K, Pitkänen A. 2009. Genes relevant to epileptogenic mechanisms. Teoksessa: Avanzini G, Noebels J (toim.), Genetics of Epilepsy and Genetic Epilepsies.John Libbey Eurotext. ss. 31-38. 2009
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Immonen RJ, Kharatishvili I, Sierra A, Einula C, Pitkänen A, Gröhn OH. 2008. Manganese enhanced MRI detects mossy fiber sprouting rather than neurodegeneration, gliosis or seizure-activity in the epileptic rat hippocampus NEUROIMAGE 40: 1718-1730. 2008
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Noè F, Pool AH, Nissinen J, Gobbi M, Bland R, Rizzi M, Balducci C, Ferraguti F, Sperk G, During MJ, Pitkänen A, Vezzani A. 2008. Neuropeptide Y gene therapy decreases chronic spontaneous seizures in a rat model of temporal lobe epilepsy. BRAIN 131 6: 1506-1515. 2008
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Nissinen J, Pitkänen A. 2007. Effect of antiepileptic drugs on spontaneous seizures in epileptic rats. EPILEPSY RESEARCH 73 2: 181-191. 2007
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Sisodiya S, Cross JH, Blümcke I, Chadwick D, Craig J, Crino PB, Debenham P, Delanty N, Elmslie F, Gardiner M, Golden J, Goldstein D, Greenberg DA, Guerrini R, Hanna M, Harris J, Harrison P, Johnson MR, Kirov G, Kullman DM, Makoff A, Marini C. 2007. Genetics of epilepsy: epilepsy research foundation workshop report. EPILEPTIC DISORDERS 9 2: 194-236. 2007
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Siiskonen H, Oikari S, Korhonen V-P, Pitkänen A, Voikar V, Kettunen M, Hakumäki J, Wahlfors T, Pussinen R, Penttonen M, Kiehne K, Kaasinen SK, Alhonen L, Jänne J, Herzig K-H. 2007. Diazepam binding inhibitor overexpression in mice causes hydrocephalus, decreases plasticity in excitatory synapses and impairs hippocamus-depend learning. MOLECULAR AND CELLULAR NEUROSCIENCE (SAN DIEGO CA) 34 2: 199-208. 2007
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Pitkänen A. 2007. Neuroprotection with anti-epileptic drugs: state of the evidence: Trimble MR, Seizure Freedom: Clinical, Research and Quality of Life Perspectives.Clarius Press. 9-27. 2007
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Pitkänen A, Mathiesen C, Rønn LCB, Møller A, Nissinen J. 2007. Effect of novel AMPA antagonist, NS1209, on status epilepticus. An experimental study in rat EPILEPSY RESEARCH 74 1: 45-54. 2007
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Noe' F, Nissinen J, Pitkänen A, Gobbi M, Sperk G, During M, Vezzani A. 2007. Gene therapy in epilepsy: The focus on NPY. PEPTIDES 28 2: 377-383. 2007
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Pitkänen A, Kharatisvili I, Karhunen H, Lukasiuk K, Immonen R, Nairismägi J, Gröhn O, Nissinen J. 2007. Epileptogenesis in experimental models. EPILEPSIA. SUPPLEMENT 48 2: 13-20. 2007
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Narkilahti S, Jutila L, Alafuzoff I, Karkola K, Paljärvi L, Immonen A, Vapalahti M, Mervaala E, Kälviäinen R, Pitkänen A. 2007. Increased expression of caspase 2 in experimental and human temporal lobe epilepsy NEUROMOLECULAR MEDICINE 9 2: 129-144. 2007
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Kharatishvili I, Immonen R, Gröhn O, Pitkänen A. 2007. Quantitative diffusion MRI of hippocampus as a surrogate marker for post-traumatic epileptogenesis. BRAIN 130 12: 3155-3168. 2007
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Keck CA, Thompson HJ, Pitkänen A, LeBold DG, Morales DM, Plevy JB, Puri R, Zhao B, Dichter M, McIntosh TK. 2007. The novel antiepileptic agent RWJ-333369-A, but not its analog RWJ-333369, reduces regional cerebral edema without affecting neurobehavioral outcome or cell death following experimental traumatic brain injury. RESTORATIVE NEUROLOGY AND NEUROSCIENCE 25 2: 77-90. 2007
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Karhunen H, Bezvenyuk Z, Nissinen J, Sivenius J, Jolkkonen J, Pitkänen A, Sivenius J. 2007. Epileptogenesis after cortical photothrombotic brain lesion in rats. NEUROSCIENCE 148 1: 314-324. 2007
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Gröhn O, Pitkänen A. 2007. Magnetic resonance imaging in animal models of epilepsy-noninvasive detection of structural alterations. EPILEPSIA. SUPPLEMENT 48 4: 3-10. 2007
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Goffin K, Nissinen J, Van Laere K, Pitkänen A. 2007. Cyclicity of spontaneous recurrent seizures in pilocarpine model of temporal lobe epilepsy in rat. EXPERIMENTAL NEUROLOGY 205: 501-505. 2007
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Majak K, Pitkänen A. 2007. Mechanisms of emotional learning in normal and epileptic brain: Natsume K, Hanazawa A, Miki T, Brain-Inspired IT III.Elsevier. International Congress Series. 22-27. 2007
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Nairismägi J, Pitkänen A, Narkilahti S, Huttunen J, Kauppinen RA, Gröhn OHJ. 2006. Manganese-enhanced magnetic resonance imaging of mossy fiber plasticity in vivo. NEUROIMAGE 30 1: 130-135. 2006
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Pitkänen A. 2006. New data suggest that discontinuation of status epilepticus is not necessary for antiepileptogenic effect in immature brain. EPILEPSY CURRENTS 6 5: 170-172. 2006
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Pitkänen A, Mcintosh TK. 2006. Animal models of post-traumatic epilepsy. JOURNAL OF NEUROTRAUMA (NEW YORK NY) 23 2: 241-261. 2006
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Pitkänen A, Gilliam F. 2006. Change over of the baton. EPILEPSY RESEARCH 70 2-3: 95. 2006
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Pirttilä TJ, Pitkänen A. 2006. Cystatin C expression is increased in the hippocampus following photothrombotic stroke in rat. NEUROSCIENCE LETTERS 395 2: 108-113. 2006
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Lukasiuk K, Dabrowski M, Adach A, Pitkänen A. 2006. Chapter 11 Epileptogenesis-related genes revisited. PROGRESS IN BRAIN RESEARCH (AMSTERDAM) 158: 223-241. 2006
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Nairismägi J, Pitkänen A, Kettunen MI, Kauppinen RA, Kubova H. 2006. Status epilepticus in 12-day-old rats leads to temporal lobe neurodegeneration and volume reduction: A histologic and MRI study. EPILEPSIA (NY) 47 3: 479-488. 2006
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Lahtinen L, Lukasiuk K, Pitkänen A. 2006. Increased expression and activity of urokinase-type plasminogen activator during epileptogenesis. EUROPEAN JOURNAL OF NEUROSCIENCE (OXFORD) 24 7: 1935-1945. 2006
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Kharatishvili I, Nissinen JP, McIntosh TK, Pitkänen A. 2006. A model of posttraumatic epilepsy induced by lateral fluid-percussion brain injury in rats. NEUROSCIENCE 140: 685-697. 2006
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Kemppainen EJS, Nissinen J, Pitkänen A. 2006. Fear conditioning is impaired in systemic kainic acid and amygdala-stimulation models of epilepsy. EPILEPSIA (NY) 47 5: 820-829. 2006
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Karhunen H, Nissinen J, Sivenius J, Jolkkonen J, Pitkänen A. 2006. A long-term video-EEG and behavioral follow-up after endothelin-1 induced middle cerebral artery occlusion in rats. EPILEPSY RESEARCH 72: 25-38. 2006
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Salmenperä T, Könönen M, Roberts N, Vanninen R, Pitkänen A, Kälviäinen R, Könönen M. 2005. Hippocampal damage in newly diagnosed focal epilepsy: a prospective MRI study. NEUROLOGY 64: 62-68. 2005
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Päivinen N, Lammi S, Pitkänen A, Nissinen J, Penttonen M, Grönfors T. 2005. Epileptic seizure detection: A nonlinear viewpooint. COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE 79 2: 151-159. 2005
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Pitkänen A, Kharatishvili I, Narkilahti S, Lukasiuk K, Nissinen J. 2005. Administration of diazepam during status epilepticus reduces development and severity of epilepsy in rat. EPILEPSY RESEARCH 63: 27-42. 2005
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Pitkänen A, Gröhn O. 2005. Experimental febrile seizures require an undetermined factor for induction of hippocampal sclerosis in immature rat brain. EPILEPSY CURRENTS 53 3: 98-100. 2005
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Pirttilä TJ, Manninen A, Jutila L, Nissinen J, Kälviäinen R, Vapalahti M, Immonen A, Paljärvi L, Karkola K, Alafuzoff I, Mervaala E, Pitkänen A. 2005. Cystatin C expression is associated with granule cell dispersion in epilepsy. ANNALS OF NEUROLOGY 58 2: 211-223. 2005
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Pirttilä TJ, Lukasiuk K, Håkansson K, Grubb A, Abrahamson M, Pitkänen A. 2005. Cystatin C modulates neurodegeneration and neurogenesis following status epilepticus in mouse. NEUROBIOLOGY OF DISEASE (SAN DIEGO CA) 20: 241-253. 2005
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Morales DM, Marklund N, Lebold D, Thompson HJ, Pitkanen A, Maxwell WL, Longhi L, Laurer H, Maegele M, Neugebauer E, Graham DI, Stocchetti N, McIntosh TK. 2005. Experimental models of traumatic brain injury: Do we really need to build a better mousetrap?. NEUROSCIENCE 136 4: 971-989. 2005
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Karhunen H, Jolkkonen J, Sivenius J, Pitkänen A. 2005. Epileptogenesis after experimental focal cerebral ischemia. NEUROCHEMICAL RESEARCH 30 12: 1529-1542. 2005
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Goncalves Pereira PM, Insausti R, Artacho-Pérula E, Salmenperä T, Kälviäinen R, Pitkänen A. 2005. MR volumetric analysis of the piriform cortex and cortical amygdala in drug-refractory temporal lobe epilepsy. AJNR. AMERICAN JOURNAL OF NEURORADIOLOGY 26: 319-332. 2005
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Narkilahti S, Pitkänen A. 2005. Caspase 6 expression in the rat hippocampus during epileptogenesis and epilepsy. NEUROSCIENCE 131 4: 887-897. 2005
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Nissinen J, Large CH, Stratton SC, Pitkänen A. 2004. Effect of lamotrigine treatment on epileptogenesis: an experimental study in rat EPILEPSY RESEARCH 58 2-3: 119-132. 2004
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Pitkänen A. 2004. New pharmacotherapy for epilepsy. IDRUGS: THE INVESTIGATIONAL DRUGS JOURNAL 7 5: 471-477. 2004
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Pitkänen A. 2004. Denervation and reinnervation of amygdaloid neurons in drug-refratory temporal lobe epilepsy EPILEPSY CURRENTS 4 2: 78-79. 2004
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Pitkänen A, Narkilahti S, Bezvenyuk Z, Haapalinna A, Nissinen J. 2004. Atipamezole, an alfa2-adrenoceptor antagonist, has disease modifying effects on epileptogenesis in rats EPILEPSY RESEARCH 61: 119-140. 2004
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Pitkänen A, Kubova H. 2004. Antiepileptic drugs in neuroprotections. EXPERT OPINION ON PHARMACOTHERAPY 5 4: 777-798. 2004
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Niittykoski M, Nissinen J, Penttonen M, Pitkänen A. 2004. Electrophysiologic changes in the lateral and basal amygdaloid nuclei in temporal lobe epilepsy: an in vitro study in epileptic rats. NEUROSCIENCE 124: 269-281. 2004
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Nairismägi J, Gröhn OHJ, Kettunen MI, Nissinen J, Kauppinen RA, Pitkänen A. 2004. Progression of brain damage after status epilepticus and its association with epileptogenesis: a quantitative MRI study in a rat model of temporal lobe epilepy EPILEPSIA (NY) 45 9: 1024-1034. 2004
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Majak K, Rönkkö S, Kemppainen S, Pitkänen A. 2004. Projections from the amygdaloid complex to the piriform cortex: A PHA-L study in the rat. JOURNAL OF COMPARATIVE NEUROLOGY 476: 414-428. 2004
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Majak K, Pitkänen A. 2004. Do seizures cause irreversible cognitive damage? Evidence from animal studies. EPILEPSY & BEHAVIOR. SUPPLEMENT 5: S35-S44. 2004
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Lähteinen S, Pitkänen A, Knuuttila J, Törönen P, Castrén E. 2004. Brain-derived neurotrophic factor signaling modifies hippocampal gene expression during epileptogenesis in transgenic mice. EUROPEAN JOURNAL OF NEUROSCIENCE (OXFORD) 19 12: 3245-3254. 2004
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Lukasiuk K, Pitkänen A. 2004. Large-scale analysis of gene expression in epilepsy reseach: is synthesis alreasy possible?. NEUROCHEMICAL RESEARCH 29 6: 1169-1178. 2004
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Kubová H, Mares P, Suchomelová L, Brozek G, Druga R, Pitkänen A. 2004. Status epilepticus in immature rats leads to behavioural and cognitive impairment and epileptogenesis. EUROPEAN JOURNAL OF NEUROSCIENCE (OXFORD) 19 12: 3255-3265. 2004
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Kemppainen S, Pitkänen A. 2004. Damage to the amygdalo-hippocampal projection in temporal lobe epilepsy: A tract-tracing study in chronic epileptic rats. NEUROSCIENCE 126 2: 485-501. 2004
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Pitkänen A, Savander M, Nurminen N, Ylinen A. 2003. Intrinsic synaptic circuitry of the amygdala ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 985: 34-49. 2003
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The Amygdala in Brain Function: Basic and Clinical Approaches. Shinnick-Gallagher P, Pitkänen A, Shekhar A, Cahill L. 2003 2003
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Sutula TP, Hagen J, Pitkänen A. 2003. Do epileptic seizures damage the brain?. CURRENT OPINION IN NEUROLOGY (PHILADELPHIA PA) 16 2: 189-195. 2003
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Stables JP, Bertram E, Dudek FE, Holmes G, Mathern G, Pitkanen A, White HS. 2003. Therapy discovery for pharmacoresistant epilepsy and for disease-modifying therapeutics: summary of the NIH/NINDS/AES models II workshop. EPILEPSIA (NY) 44 12: 1472-1478. 2003
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Pitkänen A. 2003. Tunteiden neurobiologiaa. DUODECIM 119: 1471-1478. 2003
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Pitkänen A. 2003. Clinical trials in neuroprotection. IDRUGS: THE INVESTIGATIONAL DRUGS JOURNAL 6 3: 200-202. 2003
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Pitkänen A. 2003. American Epilepsy Society - 56th Annual Meeting. IDRUGS: THE INVESTIGATIONAL DRUGS JOURNAL 6 2: 102-103. 2003
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Laurén HB, Pitkänen A, Nissinen J, Soini SL, Korpi ER, Holopainen IE. 2003. Selective changes in gamma-aminobutyric acid type A receptor subunits in the hippocampus in spontaneously seizing rats with chronic temporal lobe epilepsy. NEUROSCIENCE LETTERS 349: 58-62. 2003
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Narkilahti S, Pirttilä TJ, Lukasiuk K, Tuunanen J, Pitkänen A. 2003. Expression and activation of caspase 3 following status epilepticus in the rat. EUROPEAN JOURNAL OF NEUROSCIENCE (OXFORD) 18 6: 1486-1496. 2003
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Narkilahti S, Nissinen J, Pitkänen A. 2003. Administration of caspase 3 inhibitor during and after status epilepticus in rat: effect on neuronal damage and epileptogenesis. NEUROPHARMACOLOGY 44: 1068-1088. 2003
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Majak K, Pitkänen A. 2003. Projections from the periamygdaloid cortex to the amygdaloid complex, the hippocampal formation, and the parahippocampal region: A PHA-L study in the rat. HIPPOCAMPUS 13 8: 922-942. 2003
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Majak K, Pitkänen A. 2003. Activation of the amygdalo-entorhinal pathway in fear-conditioning in rat. EUROPEAN JOURNAL OF NEUROSCIENCE (OXFORD) 18 6: 1652-1659. 2003
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Lähteinen S, Pitkänen A, Koponen E, Saarelainen T, Castrén E. 2003. Exacerbated status epilepticus and acute cell loss, but no changes in epileptogenesis, in mice with increased brain-derived neurotrophic factor signaling NEUROSCIENCE 122: 1081-1092. 2003
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Lukasiuk K, Kontula L, Pitkänen A. 2003. cDNA profiling of epileptogenesis in the rat brain. EUROPEAN JOURNAL OF NEUROSCIENCE (OXFORD) 17 2: 271-279. 2003
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Karhunen H, Pitkänen A, Virtanen T, Gureviciene I, Pussinen R, Ylinen A, Sivenius J, Nissinen J, Jolkkonen J. 2003. Long-term functional consequences of transient occlusion of the middle cerebral artery in rats: a 1-year follow-up of the development of epileptogenesis and memory impairment in relation to sensorimotor deficits. EPILEPSY RESEARCH 54 1: 1-10. 2003
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Griffin JL, Lehtimäki KK, Valonen PK, Gröhn OHJ, Kettunen MI, Ylä-Herttuala S, Pitkänen A, Nicholson JK, Kauppinen RA. 2003. Assignment of 1H nuclear magnetic resonance visible polyunsaturated fatty acids in BT4C gliomas undergoing ganciclovir-thymidine kinase gene therapy-induced programmed cell death. CANCER RESEARCH 63: 3195-3201. 2003
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Pitkänen A. 2002. Prevention of epileptogenesis: Levy RH, Mattson RH, Meldrum BS, Perucca E, Antiepileptic Drugs.Lippincott. 169-176. 2002
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Pitkänen A. 2002. Efficacy of current antiepileptics to prevent neurodegeneration in epilepsy models. EPILEPSY RESEARCH 50 1-2: 141-160. 2002
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Pitkänen A. 2002. Drug-mediated neuroprotection and anti-epileptogenesis. NEUROLOGY. SUPPLEMENT 59 5: S27-S33. 2002
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Pitkänen A, Sutula TP. 2002. Is epilepsy a progressive disorder? Prospects for new therapeutic approaches in temporal-lobe epilepsy. LANCET NEUROLOGY 1 3: 173-181. 2002
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Pitkänen A, Nissinen J, Nairismägi J, Lukasiuk K, Gröhn OHJ, Miettinen R, Kauppinen R. 2002. Progression of neuronal damage after status epilepticus and during spontaneous seizures in a rat model of temporal lobe epilepsy: Sutula T, Pitkänen A, Do Seizures Damage the Brain.Elsevier. Progress in Brain Research. 67-83. 2002
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Pitkänen A, Kemppainen S. 2002. Comparison of the distribution of calcium-binding proteins and intrinsic connectivity in the lateral nucleus of the rat, monkey, and human amygdala. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 71 3: 369-377. 2002
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Pitkanen A, Kelly JL, Amaral DG. 2002. Projections from the lateral, basal, and accessory basal nuclei of the amygdala to the entorhinal cortex in the macaque monkey HIPPOCAMPUS 12 2: 186-205. 2002
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Majak K, Pikkarainen M, Kemppainen S, Jolkkonen E, Pitkänen A. 2002. Projections from the amygdaloid complex to the claustrum and the endopiriform nucleus: a Phaseolus vulgaris leucoagglutinin study in the rat JOURNAL OF COMPARATIVE NEUROLOGY 451 3: 236-249. 2002
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Lukasiuk K, Pirttilä TJ, Pitkänen A. 2002. Upregulation of cystatin C expression in the rat hippocampus during epileptogenesis in the amygdala stimulation model of temporal lobe epilepsy. EPILEPSIA. SUPPLEMENT 43 5: 137-145. 2002
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Kubová H, Druga R, Haugvicová R, Suchomelová L, Pitkanen A. 2002. Dynamic changes of status epilepticus-induced neuronal degeneration in the mediodorsal nucleus of the thalamus during postnatal development of the rat. EPILEPSIA. SUPPLEMENT 43 5: 54-60. 2002
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Kemppainen S, Jolkkonen E, Pitkänen A. 2002. Projections from the posterior cortical nucleus of the amygdala to the hippocampal formation and parahippocampal region in rat. HIPPOCAMPUS 12 6: 735-755. 2002
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Jutila L, Immonen A, Partanen K, Partanen J, Mervaala E, Ylinen A, Alafuzoff I, Paljärvi L, Karkola K, Vapalahti M, Pitkänen A. 2002. Neurobiology of epileptogenesis in the temporal lobe: Pickard JD, Dolenc VV, Antunes JL, Reulen H-J, Sindou M, Strong AJ, de Tribolet N, Tulleken CAF, Vapalahti M, Advances and Technical Standards in Neurosurgery.Springer. 3-22. 2002
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Jolkkonen E, Miettinen R, Pikkarainen M, Pitkänen A. 2002. Projections from the amygdaloid complex to the magnocellular cholinergic basal forebrain in rat. NEUROSCIENCE 111 1: 133-149. 2002
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Lähteinen S, Pitkänen A, Saarelainen T, Nissinen J, Koponen E, Castrén E. 2002. Decreased BDNF signalling in transgenic mice reduces epileptogenesis. EUROPEAN JOURNAL OF NEUROSCIENCE (OXFORD) 15: 721-734. 2002
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Lukasiuk K, Tuunanen J, Halonen T, Pitkänen A. 2001. Time course and mechanisms of amygdaloid damage after kainate-induced status epilepticus in rat. Teoksessa: Turski L, Schoepp DD, Cavalheiro EA (toim.), Excitatory Amino Acids: Ten Years Later.IOS. Biomedical and Health Research. ss. 289-297. 2001
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Salmenperä T, Kälviäinen R, Partanen K, Pitkänen A. 2001. Hippocampal and amygdaloid damage in partial epilepsy A cross-sectional MRI study of 241 patients. EPILEPSY RESEARCH 46: 69-82. 2001
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Pirttilä T-RM, Pitkänen A, Tuunanen J, Kauppinen RA. 2001. Ex vivo MR microimaging of neuronal damage after kainate-induced status epilepticus in rat: correlation with quantitative histology. MAGNETIC RESONANCE IN MEDICINE 46 5: 946-954. 2001
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Pikkarainen M, Pitkanen A. 2001. Projections from the lateral, basal and accessory basal nuclei of the amygdala to the perirhinal and postrhinal cortices in rat CEREBRAL CORTEX (NEW YORK NY) 11 11: 1064-1082. 2001
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Nissinen J, Lukasiuk K, Pitkänen A. 2001. Is mossy fiber sprouting present at the time of the first spontaneous seizures in rat experimental temporal lobe epilepsy?. HIPPOCAMPUS 11 3: 299-310. 2001
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Sutula TP, Pitkänen A. 2001. More evidence for seizure-induced neuron loss: is hippocampal sclerosis both cause and effect of epilepsy? NEUROLOGY 57: 169-170. 2001
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Kubová H, Druga R, Lukasiuk K, Suchomelová L, Haugvicová R, Jirmanová I, Pitkänen A. 2001. Status epilepticus causes necrotic damage in the mediodorsal nucleus of the thalamus in immature rats JOURNAL OF NEUROSCIENCE 21 10: 3593-3599. 2001
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Jutila L, Immonen A, Partanen K, Partanen J, Mervaala E, Ylinen A, Alafuzoff I, Paljärvi L, Karkola K, Vapalahti M, Pitkänen A. 2001. Neurobiology of epileptogenesis in the temporal lobe: Pickard JD, Dolenc VV, Lobo Antunes J, Reulen H-J, Sindou M, Strong AJ, de Tribolet N, Tulleken CAF, Vapalahti M, Advances and Technical Standards in Neurosurgery.Springer. 4-22. 2001
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Jolkkonen E, Pikkarainen M, Kemppainen S, Pitkänen A. 2001. Interconnectivity between the amygdaloid complex and the amygdalostriatal transition area: a PHA-L study in rat. JOURNAL OF COMPARATIVE NEUROLOGY 431: 39-58. 2001
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Jolkkonen E, Miettinen R, Pitkänen A. 2001. Projections from the amygdalo-piriform transition area to the amygdaloid coplex: A PHA-L study in rat. JOURNAL OF COMPARATIVE NEUROLOGY 432: 440-465. 2001
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Halonen T, Nissinen J, Pitkänen A. 2001. Chronic elevation of brain GABA levels beginning two days after status epilepticus does not prevent epileptogenesis in rats. NEUROPHARMACOLOGY 40 4: 536-550. 2001
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Halonen T, Nissinen J, Pitkanen A. 2001. Effect of lamotrigine treatment on status epilepticus-induced neuronal damage and memory impairment in rat. EPILEPSY RESEARCH 46 3: 205-223. 2001
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Jutila L, Ylinen A, Partanen K, Alafuzoff I, Mervaala E, Partanen J, Vapalahti M, Vainio P, Pitkänen A. 2001. MR volumetry of the entorhinal, perirhinal, and temporopolar cortices in drug-refractory temporal lobe epilepsy. AJNR. AMERICAN JOURNAL OF NEURORADIOLOGY 22: 1490-1501. 2001
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Pitkänen A, Nissinen J, Lukasiuk K, Jutila L, Paljärvi L, Salmenperä T, Karkola K, Vapalahti M, Ylinen A. 2000. Association between the density of mossy fiber sprouting and seizure frequency in experimental and human temporal lobe epilepsy EPILEPSIA. SUPPLEMENT 41 6: S24-S29. 2000
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Tuunanen J, Pitkänen A. 2000. Do seizures cause neuronal damage in rat amygdala kindling? EPILEPSY RESEARCH 39: 171-176. 2000
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Salmenperä T, Kälviäinen R, Partanen K, Pitkänen A. 2000. Quantitative MRI volumetry of the entorhinal cortex in temporal lobe epilepsy. SEIZURE 9: 208-215. 2000
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Salmenperä T, Kälviäinen R, Partanen K, Mervaala E, Pitkänen A. 2000. MRI volumetry of the hippocampus, amygdala, entorhinal cortex, and perirhinal cortex after status epilepticus. EPILEPSY RESEARCH 40: 155-170. 2000
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Pitkänen A. 2000. Connectivity of the rat amygdaloid complex: Aggleton JP, The Amygdala. A Functional Analysis.Oxford University Press. 31-115. 2000
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Pitkänen A, Pikkarainen M, Nurminen N, Ylinen A. 2000. Reciprocal connections between the amygdala and the hippocampal formation, perirhinal cortex, and postrhinal cortex in rat: a review ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 911: 369-391. 2000
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Mikkonen M, Pitkänen A, Soininen H, Alafuzoff I, Miettinen R. 2000. Morphology of spiny neurons in the human entorhinal cortex: intracellular filling with lucifer yellow. NEUROSCIENCE 96 3: 515-522. 2000
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Pitkänen A, Jolkkonen E, Kemppainen S. 2000. Anatomic heterogeneity of the rat amygdaloid complex. FOLIA MORPHOLOGICA (PRAHA) 59 1: 1-23. 2000
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Nissinen J, Halonen T, Koivisto E, Pitkänen A. 2000. A new model of chronic temporal lobe epilepsy induced by electrical stimulation of the amygdala in rat. EPILEPSY RESEARCH 38 2-3: 177-205. 2000
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Lukasiuk K, Pitkänen A. 2000. GABA(A)-mediated toxicity of hippocampal neurons in vitro JOURNAL OF NEUROCHEMISTRY 74 6: 2445-2454. 2000
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Liubashina O, Jolkkonen E, Pitkänen A. 2000. Projections from the central nucleus of the amygdala to the gastric related area of the dorsal vagal complex: a Phaseolus vulgaris-leucoagglutinin study in rat NEUROSCIENCE LETTERS 291: 85-88. 2000
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Lamusuo S, Pitkänen A, Jutila L, Ylinen A, Partanen K, Kälviäinen R, Ruottinen H-M, Oikonen V, Någren K, Lehikoinen P, Vapalahti M, Vainio P, Rinne JO. 2000. [11C]Flumazenil binding in the medical temporal lobe in patients with temporal lobe epilepsy. Correlation with hippocampal MR volumetry, T2 relaxometry, and neuropathology. NEUROLOGY 54: 2252-2260. 2000
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Kemppainen S, Pitkänen A. 2000. Distribution of parvalbumin, calretinin, and calbindin-D28k immunoreactivity in the rat amygdaloid complex and colocalization with gamma-aminobutyric acid JOURNAL OF COMPARATIVE NEUROLOGY 426: 441-467. 2000
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Gröhn OHJ, Kettunen MI, Mäkelä HI, Penttonen M, Pitkänen A, Lukkarinen JA, Kauppinen RA. 2000. Early detection of irreversible cerebral ischemia in the rat using dispersion of the magnetic resonance imaging relaxation time, T1rho. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 20: 1457-1466. 2000
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Tuunanen J, Lukasiuk K, Halonen T, Pitkänen A. 1999. Status epilepticus-induced neuronal damage in the rat amygdaloid complex: distribution, time-course and mechanisms NEUROSCIENCE 94 2: 473-495. 1999
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Pitkänen A, Salmenperä T, Äikiä M, Partanen K, Kälviäinen R. 1999. Seizure-induced damage to the medial temporal lobe in temporal lobe epilepsy: Sillanpää M, Gram L, Johannessen SI, Tomson T, Epilepsy and Mental Retardation.Wrightson Biomedical Publishing . 147-163. 1999
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Pikkarainen M, Rönkkö S, Savander V, Insausti R, Pitkänen A. 1999. Projections from the lateral, basal, and accessory basal nuclei of the amygdala to the hippocampal formation in rat. JOURNAL OF COMPARATIVE NEUROLOGY 403: 229-260. 1999
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Pitkänen A, Jolkkonen J. 1999. Do GABAergic circuitries play a critical role in the regulation of seizure-induced neuronal damage and synaptic reorganization in the rat hippocampus?. ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY. SUPPLEMENT 50: 443-449. 1999
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Pitkänen A, Nissinen J, Jolkkonen E, Tuunanen J, Halonen T. 1999. Effects of vigabatrin treatment on status epilepticus-induced neuronal damage and mossy fiber sprouting in the rat hippocampus. EPILEPSY RESEARCH 33: 67-85. 1999
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Lehesjoki A-E, Pitkänen A. 1999. Epilepsian geenit ja neurobiologia DUODECIM 115: 583-594. 1999
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Kälviäinen R, Pitkänen A. 1999. Prevention of seizure-induced neuronal damage and intellectual deterioration: experimental aspects and clinical implications. Teoksessa: Sillanpää M, Gram L, Johannessen SI, Tomson T (toim.), Epilepsy and Mental Retardation.Wrightson Biomedical Publishing . ss. 165 - 178. 1999
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Jongen-Rêlo AL, Pitkänen A, Amaral DG. 1999. Distribution of GABAergic cells and fibers in the hippocampal formation of the macaque monkey: an immunohistochemical and in situ hybridization study. JOURNAL OF COMPARATIVE NEUROLOGY 408: 237-271. 1999
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Halonen T, Nissinen J, Pitkänen A. 1999. Neuroprotective effect of remacemide hydrochloride in a perforant pathway stimulation model of status epilepticus in the rat. EPILEPSY RESEARCH 34: 251-269. 1999
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Gröhn OHJ, Lukkarinen JA, Silvennoinen MJ, Pitkänen A, van Zijl PCM, Kauppinen RA. 1999. Quantitative magnetic resonance imaging assessment of cerebral ischemia in rat using on-resonance T1 in the rotating frame. MAGNETIC RESONANCE IN MEDICINE 42: 268-276. 1999
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Sorvari H, Miettinen R, Soininen H, Paljärvi L, Karkola K, Pitkänen A. 1998. Calretinin-immunoreactive terminals make synapses on calbindin D28k-immunoreactive neurons in the lateral nucleus of the human amygdala. BRAIN RESEARCH 783: 355-358. 1998
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Salmenperä T, Kälviäinen R, Partanen K, Pitkänen A. 1998. Hippocampal damage caused by seizures in temporal lobe epilepsy LANCET 351: 35. 1998
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Pitkänen A. 1998. Mantelitumake DUODECIM 114: 2451-2459. 1998
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Pitkänen A, Tuunanen J, Kälviäinen R, Partanen K, Salmenperä T. 1998. Amygdala damage in experimental and human temporal lobe epilepsy. EPILEPSY RESEARCH 32: 233-253. 1998
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Pitkänen A, Halonen T. 1998. Prevention of epilepsy. TRENDS IN PHARMACOLOGICAL SCIENCES 19: 253-254. 1998
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Pitkänen A, Amaral DG. 1998. Organization of the intrinsic connections of the monkey amygdaloid complex: projections originating in the lateral nucleus. JOURNAL OF COMPARATIVE NEUROLOGY 398: 431-458. 1998
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Mikkonen M, Soininen H, Kälviäinen R, Tapiola T, Ylinen A, Vapalahti M, Paljärvi L, Pitkänen A. 1998. Remodeling of neuronal circuitries in human temporal lobe epilepsy: increased expression of highly polysialylated neural cell adhesion molecule in the hippocampus and the entorhinal cortex. ANNALS OF NEUROLOGY 44: 923-934. 1998
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Kälviäinen R, Salmenperä T, Partanen K, Vainio P, Riekkinen P Sr, Pitkänen A. 1998. Recurrent seizures may cause hippocampal damage in temporal lobe epilepsy. NEUROLOGY 50: 1377-1382. 1998
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Juottonen K, Laakso MP, Insausti R, Lehtovirta M, Pitkänen A, Partanen K, Soininen H. 1998. Volumes of the entorhinal and perirhinal cortices in Alzheimer`s disease NEUROBIOLOGY OF AGING 19 1: 15-22. 1998
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Jolkkonen E, Pitkänen A. 1998. Intrinsic connections of the rat amygdaloid complex: projections originating in the central nucleus JOURNAL OF COMPARATIVE NEUROLOGY 395: 53-72. 1998
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Insausti R, Juottonen K, Soininen H, Insausti AM, Partanen K, Vainio P, Laakso MP, Pitkänen A. 1998. MR volumetric analysis of the human entorhinal, perirhinal, and temporopolar cortices. AJNR. AMERICAN JOURNAL OF NEURORADIOLOGY 19: 659-671. 1998
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Tuunanen J, Halonen T, Pitkänen A. 1997. Decrease in somatostatin-immunoreactive neurons in the rat amygdaloid complex in a kindling model of temporal lobe epilepsy. EPILEPSY RESEARCH 26: 315-327. 1997
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Savander V, Miettinen R, Ledoux JE, Pitkänen A. 1997. Lateral nucleus of the rat amygdala is reciprocally connected with basal and accessory basal nuclei: a light and electron microscopic study. NEUROSCIENCE 77 3: 767-781. 1997
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Savander V, Ledoux JE, Pitkänen A. 1997. Interamygdaloid projections of the basal and accessory basal nuclei of the rat amygdaloid complex. NEUROSCIENCE 76 3: 725-735. 1997
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Pitkänen A, Savander V, Ledoux JE. 1997. Organization of intra-amygdaloid circuitries in the rat: an emerging framework for understanding functions of the amygdala. TRENDS IN NEUROSCIENCES 20 11: 517-523. 1997
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Mikkonen M, Soininen H, Pitkänen A. 1997. Distribution of parvalbumin-, calretinin-, and calbindin-D28k-immunoreactive neurons and fibers in the human entorhinal cortex. JOURNAL OF COMPARATIVE NEUROLOGY 388: 64-88. 1997
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Miettinen M, Pitkänen A, Miettinen R. 1997. Distribution of calretinin-immunoreactivity in the rat entorhinal cortex:coexistence with GABA JOURNAL OF COMPARATIVE NEUROLOGY 378: 363-378. 1997
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Kälviäinen R, Salmenperä T, Partanen K, Vainio P, Riekkinen P Sr, Pitkänen A. 1997. MRI volumetry and T2 relaxometry of the amygdala in newly diagnosed and chronic temporal lobe epilepsy. EPILEPSY RESEARCH 28: 39-50. 1997
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Kälviäinen R, Partanen K, Äikiä M, Mervaala E, Vainio P, Riekkinen PJ Sr, Pitkänen A. 1997. MRI-based hippocampal volumetry and T2 relaxometry: correlation to verbal memory performance in newly diagnosed epilepsy patients with left-sided temporal lobe focus. NEUROLOGY 48: 286-287. 1997
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Jolkkonen J, Kähkönen K, Pitkänen A. 1997. Cholinergic deafferentation exacerbates seizure-induced loss of somatostatin-immunoreactive neurons in the rat hippocampus. NEUROSCIENCE 80 2: 401-411. 1997
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Jolkkonen J, Jolkkonen E, Pitkänen A. 1997. Seizure-induced damage to somatostatin-immunoreactive neurons in the rat hippocampus is regulated by fimbria-fornix transection. EXPERIMENTAL NEUROLOGY 145: 141-153. 1997
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Tuunanen J, Halonen T, Pitkänen A. 1996. Status epilepticus causes selective regional damage and loss of GABAergic neurons in the rat amygdaloid complex. EUROPEAN JOURNAL OF NEUROSCIENCE (OXFORD) 8: 2711-2725. 1996
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Sorvari H, Soininen H, Pitkänen A. 1996. Calretinin-immunoreactive cells and fibers in the human amygdaloid complex JOURNAL OF COMPARATIVE NEUROLOGY 369: 188-208. 1996
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Sorvari H, Soininen H, Pitkänen A. 1996. Calbindin-D28K-immunoreactive cells and fibres in the human amygdaloid complex. NEUROSCIENCE 75 2: 421-443. 1996
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Sorvari H, Miettinen R, Soininen H, Pitkänen A. 1996. Parvalbumin-immunoreactive neurons make inhibitory synapses on pyramidal cells in the human amygdala: a light and electron microscopic study. NEUROSCIENCE LETTERS 217: 93-96. 1996
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Savander V, LeDoux JE, Pitkänen A. 1996. Topographic projections from the periamygdaloid cortex to select subregions of the lateral nucleus of the amygdala in the rat NEUROSCIENCE LETTERS 211: 167-170. 1996
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Savander V, Go C-G, Ledoux JE, Pitkänen A. 1996. Intrinsic connections of the rat amygdaloid complex: projections originating in the accessory basal nucleus. JOURNAL OF COMPARATIVE NEUROLOGY 374: 291-313. 1996
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Pitkänen A. 1996. Treatment with antiepileptic drugs: Possible neuroprotective effects. NEUROLOGY. SUPPLEMENT 47 1: S12-S16. 1996
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Pitkänen A, Tuunanen J, Halonen T. 1996. Vigabatrin and carbamazepine have different efficacies in the prevention of status epilepticus induced neuronal damage in the hippocampus and amygdala. EPILEPSY RESEARCH 24: 29-45. 1996
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Pitkänen A, Laakso M, Kälviäinen R, Partanen K, Vainio P, Lehtovirta M, Riekkinen P Sr, Soininen H. 1996. Severity of hippocampal atrophy correlates with the prolongation of MRI T2 relaxation time in temporal lobe epilepsy but not in Alzheimer's disease NEUROLOGY 46: 1724-1730. 1996
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Jolkkonen J, Halonen T, Jolkkonen E, Nissinen J, Pitkänen A. 1996. Seizure-induced damage to the hippocampus is prevented by modulation of the GABAergic system. NEUROREPORT 7: 2031-2035. 1996
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Halonen T, Nissinen J, Jansen JA, Pitkänen A. 1996. Tiagabine prevents seizures, neuronal damage and memory impairment in experimental status epilepticus. EUROPEAN JOURNAL OF PHARMACOLOGY 299: 69-81. 1996
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Kuikka JT, Pitkänen A, Lepola U, Partanen K, Vainio P, Bergström KA, Wieler HJ, Kaiser KP, Mittelbach L, Koponen H, Leinonen E, Riekkinen PJ. 1995. Abnormal regional benzodiazepine receptor uptake in the prefrontal cortex in patients with panic disorder. NUCLEAR MEDICINE COMMUNICATIONS 16: 273-280. 1995
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Pitkänen A, Stefanacci L, Farb CR, Go GG, LeDoux JE, Amaral DG. 1995. Intrinsic connections of the rat amygdaloid complex: projections originating in the lateral nucleus JOURNAL OF COMPARATIVE NEUROLOGY 356: 288-310. 1995
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Pitkänen A, Tuunanen J, Halonen T. 1995. Subiculum, presubiculum and parasubiculum have different sensitivities to seizure-induced neuronal damage in the rat. NEUROSCIENCE LETTERS 192: 65-68. 1995
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Savander V, Go C-G, LeDoux JE, Pitkänen A. 1995. Intrinsic connections of the rat amygdaloid complex: projections originating in the basal nucleus. JOURNAL OF COMPARATIVE NEUROLOGY 361: 345-368. 1995
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Soininen H, Partanen K, Pitkänen A, Hallikainen M, Hänninen T, Helisalmi S, Mannermaa A, Ryynänen M, Koivisto K, Riekkinen P Sr. 1995. Decreased hippocampal volume asymmetry on MRIs in nondemented elderly subjects carrying the apolipoprotein E epsilon 4 allele. NEUROLOGY 45: 391-392. 1995
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Sorvari H, Soininen H, Paljärvi L, Karkola K, Pitkänen A. 1995. Distribution of parvalbumin-immunoreactive cells and fibers in the human amygdaloid complex JOURNAL OF COMPARATIVE NEUROLOGY 360: 185-212. 1995