ASTRID SUBRIZI

Akatemiatutkija

I study and develop ocular drug delivery systems. I am interested in the design and functionality of nanocarriers, in the selection of targeting moieties that facilitate safe and precise delivery of drugs to ocular tissues, and in the investigation of ocular barriers and their effects on ocular pharmacokinetics.

Yhteystiedot

Organisaatio

Terveystieteiden tiedekunta, Farmasian laitos

Sähköposti

astrid.subrizi@uef.fi

Puhelin

040 016 3407

Tutkimusryhmät - UEF

Julkaisut

Balasso, Anna; Subrizi, Astrid; Salmaso, Stefano; Mastrotto, Francesca; Garofalo, Mariangela; Tang, Miao; Chen, Mei; Xu, Heping; Urtti, Arto; Caliceti, Paolo. 2021. Screening of chemical linkers for development of pullulan bioconjugates for intravitreal ocular European journal of pharmaceutical sciences 161: 105785. 2021
Pretto, Chiara; Tang, Miao; Chen, Mei; Xu, Heping; Subrizi, Astrid; Urtti, Arto; Hest, Jan CM. 2021. Cowpea Chlorotic Mottle Virus-Like Particles as Potential Platform for Antisense Oligonucleotide Delivery in Posterior Segment Ocular Diseases Macromolecular bioscience 21 8: 2100095. 2021
Sadeghi, Amir; Puranen, Jooseppi; Ruponen, Marika; Valtari, Annika; Subrizi, Astrid; Ranta, Veli-Pekka; Toropainen, Elisa; Urtti, Arto. 2021. Pharmacokinetics of intravitreal macromolecules: scaling between rats and rabbits European journal of pharmaceutical sciences 159: 105720. 2021
Lamminsalo, Marko; Karvinen, Timo; Subrizi, Astrid; Urtti, Arto; Ranta, Veli-Pekka. 2020. Extended Pharmacokinetic Model of the Intravitreal Injections of Macromolecules in Rabbits. Part 2: Parameter Estimation Based on Concentration Dynamics in the Vitreous, Retina, and Aqueous Humor Pharmaceutical research 37 11: 226. 2020
Ramsay, Eva; Raviña, Manuela; Sarkhel, Sanjay; Hehir, Sarah; Cameron, Neil R; Ilmarinen, Tanja; Skottman, Heli; Kjems, Jørgen; Urtti, Arto; Ruponen, Marika; Subrizi, Astrid. 2020. Avoiding the Pitfalls of siRNA Delivery to the Retinal Pigment Epithelium with Physiologically Relevant Cell Models. Pharmaceutics 12 7: 667. 2020
Tavakoli, Shirin; Kari, Otto Kalevi; Turunen, Tiina; Lajunen, Tatu; Schmitt, Mechthild; Lehtinen, Julia; Tasaka, Fumitaka; Parkkila, Petteri; Ndika, Joseph; Viitala, Tapani; Alenius, Harri; Urtti, Arto; Subrizi, Astrid. 2020. Diffusion and Protein Corona Formation of Lipid-Based Nanoparticles in the Vitreous Humor: Profiling and Pharmacokinetic Considerations Molecular pharmaceutics 2021; 18 2: 699-713. 2020
Subia, B; Reinisalo, M; Dey, N; Tavakoli, S; Subrizi, A; Ganguli, M; Ruponen, M. 2019. Nucleic acid delivery to differentiated retinal pigment epithelial cells using cell-penetrating peptide as a carrier European journal of pharmaceutics and biopharmaceutics 140: 91-99. 2019
Subrizi, A; Amo, EMD; Korzhakov-Vlakh, V; Tennikova, T; Ruponen, M; Urtti, A. 2019. Design principles of ocular drug delivery systems: importance of drug payload, release rate, and material properties Drug discovery today 24 8: 1446-1457. 2019
del Amo Eva M, Rimpelä Anna-Kaisa, Heikkinen Emma, Kari Otto K, Ramsay Eva, Lajunen Tatu, Schmitt Mechthild, Pelkonen Laura, Bhattacharya Madhushree, Richardson Dominique, Subrizi Astrid, Turunen Tiina, Reinisalo Mika, Itkonen Jaakko, Toropainen Elisa, Casteleijn Marco, Kidron Heidi, Antopolsky Maxim, Vellonen Kati-Sisko, Ruponen Marika, et al.. 2017. Pharmacokinetic aspects of retinal drug delivery PROGRESS IN RETINAL AND EYE RESEARCH 57: 134-185. 2017