Heikki Tanila

Tiedot Julkaisut

Johdan Muistin neurobiologian tutkimusryhmää A. I. Virtanen -instituutissa. Selvitämme, millä mekanismeilla varhaiset Alzheimerin taudin solutason muutokset johtavan valikoivaan lähimuistin heikkenemiseen.

Tutkimusryhmät

Projektit

Neuro-Innovation 01.05.2021 - 30.04.2026

Avainsanat

Alzheimerin tauti eläinten käyttäytyminen epilepsia histopatologia muisti muistisairaudet sähköfysiologia

Julkaisut

27 kappaletta

Recommendations for Preclinical Testing of Treatments Against Alzheimer's Disease-Related Epileptiform Spikes in Transgenic Rodent Models
Jin, Nanxiang; Babiloni, Claudio; Drinkenburg, Wilhelmus H; Hajós, Mihály; Nygaard, Haakon B; Tanila, Heikki. Journal of Alzheimer's disease [Uncorrected author proof]: 1-16. 2022
Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer's disease
Andersen, Jens V.; Skotte, Niels H.; Christensen, Sofie K.; Polli, Filip S.; Shabani, Mohammad; Markussen, Kia H.; Haukedal, Henriette; Westi, Emil W.; Diaz-delCastillo, Marta; Sun, Ramon C.; Kohlmeier, Kristi A.; Schousboe, Arne; Gentry, Matthew S.; Tanila, Heikki; Freude, Kristine K.; Aldana, Blanca I.; Mann, Matthias; Waagepetersen, Helle S.. Cell death and disease 12 11: 954. 2021
Contribution of astrocytes to familial risk and clinical manifestation of schizophrenia
Koskuvi, Marja; Lehtonen, Šárka; Trontti, Kalevi; Keuters, Meike; Wu, Ying-Chieh; Koivisto, Hennariikka; Ludwig, Anastasia; Plotnikova, Lidiia; Virtanen, Pekka LJ; Räsänen, Noora; Kaipainen, Satu; Hyötyläinen, Ida; Dhungana, Hiramani; Giniatullina, Raisa; Ojansuu, Ilkka; Vaurio, Olli; Cannon, Tyrone D; Lönnqvist, Jouko; Therman, Sebastian; Suvisaari, Jaana; Kaprio, Jaakko; Lähteenvuo, Markku; Toh. Glia 2022; 70 4: 650-660. 2021
Medium-Chain Length Fatty Acids Enhance Aß Degradation by Affecting Insulin-Degrading Enzyme
Mett, Janine; Lauer, Anna A; Janitschke, Daniel; Griebsch, Lea V; Theiss, Elena L; Grimm, Heike S; Koivisto, Hennariikka; Tanila, Heikki; Hartmann, Tobias; Grimm, Marcus OW. Cells 10 11: 2941. 2021
Neuronal spreading and plaque induction of intracellular Aß and its disruption of Aß homeostasis
Roos, TT; Garcia, MG; Martinsson, I; Mabrouk, R; Israelsson, B; Deierborg, T; Kobro-Flatmoen, A; Tanila, H; Gouras, GK. Acta neuropathologica 142 4: 669-687. 2021
Phencyclidine-induced cognitive impairments in repeated touchscreen visual reversal learning tests in rats
Savolainen, Katja; Ihalainen, Jouni; Hämäläinen, Elina; Tanila, Heikki; Forsberg, Markus M. Behavioural brain research 404: 113057. 2021
Isoflurane affects brain functional connectivity in rats 1 month after exposure
Stenroos, Petteri; Pirttimäki, Tiina; Paasonen, Jaakko; Paasonen, Ekaterina; Salo, Raimo A; Koivisto, Hennariikka; Natunen, Teemu; Mäkinen, Petra; Kuulasmaa, Teemu; Hiltunen, Mikko; Tanila, Heikki; Gröhn, Olli. Neuroimage 234: 117987. 2021
Mikrogliasolut hoidon kohteeksi hermoston rappeumasairauksissa
Tienari, Pentti; Tanila, Heikki; Hiltunen, Mikko. Duodecim 137 18: 1909-1911. 2021
Deficient astrocyte metabolism impairs glutamine synthesis and neurotransmitter homeostasis in a mouse model of Alzheimer's disease
Andersen, Jens V; Christensen, Sofie K; Westi, Emil W; Diaz-delCastillo, Marta; Tanila, Heikki; Schousboe, Arne; Aldana, Blanca I; Waagepetersen, Helle S. Neurobiology of disease 2021; 148: 105198. 2020
Astrocyte remodeling in the beneficial effects of long-term voluntary exercise in Alzheimer's disease
Belaya, Irina; Ivanova, Mariia; Sorvari, Annika; Ilicic, Marina; Loppi, Sanna; Koivisto, Hennariikka; Varricchio, Alessandra; Tikkanen, Heikki; Walker, Frederick R; Atalay, Mustafa; Malm, Tarja; Grubman, Alexandra; Tanila, Heikki; Kanninen, Katja M. Journal of neuroinflammation 17 1: 271. 2020
Variant in NHLRC2 leads to increased hnRNP C2 in developing neurons and the hippocampus of a mouse model of FINCA disease
Hiltunen, Anniina E; Kangas, Salla M; Ohlmeier, Steffen; Pietilä, Ilkka; Hiltunen, Jori; Tanila, Heikki; McKerlie, Colin; Govindan, Subashika; Tuominen, Hannu; Kaarteenaho, Riitta; Hallman, Mikko; Uusimaa, Johanna; Hinttala, Reetta. Molecular medicine 26 1: 123. 2020
Response of spike-wave discharges in aged APP/PS1 Alzheimer model mice to antiepileptic, metabolic and cholinergic drugs
Jin, Nanxiang; Ziyatdinova, Sofya; Gureviciene, Irina; Tanila, Heikki. Scientific reports 10 1: 11851. 2020
Orientation selective deep brain stimulation of the subthalamic nucleus in rats
Lehto, Lauri; Canna, Antonietta; Wu, Lin; Sierra, Alejandra; Zhurakovskaya, E; Ma, Jun; Pearce, Clairice; Shaio, Maple; Filip, Pavel; Johnson, Matthew; Low, Walter; Gröhn, Olli; Tanila, Heikki; Mangia, Silvia; Michaeli, Shalom. Neuroimage 213: 116750. 2020
Diabetic phenotype in mouse and humans reduces the number of microglia around ß-amyloid plaques
Natunen, Teemu; Martiskainen, Henna; Marttinen, Mikael; Gabbouj, Sami; Koivisto, Hennariikka; Kemppainen, Susanna; Kaipainen, Satu; Takalo, Mari; Svobodová, Helena; Leppänen, Luukas; Kemiläinen, Benjam; Ryhänen, Simo; Kuulasmaa, Teemu: Rahunen, Eija: Juutinen, Sisko; Mäkinen, Petra; Miettinen, Pasi; Rauramaa, Tuomas; Pihlajamäki, Jussi; Haapasalo, Annakaisa; et al [incl. Leinonen, Ville; Tanila, H. Molecular neurodegeneration 15: 66. 2020
Iron-oxide minerals in the human tissues
Svobodova, H; Kosnác, D; Tanila, H; Wagner, A; Trnka, M; Vitovic, P; Hlinkova, J; Vavrinsky, E; Ehrlich, H; Polák, Š; Kopani, M. Biometals 33 1: 1-13. 2020
Alzheimerin taudin amyloidikuormaa vähentävät lääkkeet käännekohdassa
Tanila, Heikki. Duodecim 136 20: 2239-2245. 2020
Characterization of Epileptic Spiking Associated With Brain Amyloidosis in APP/PS1 Mice
Gureviciene, I; Ishchenko, I; Ziyatdinova, S; Jin, N; Lipponen, A; Gurevicius, K; Tanila, H. Frontiers in neurology 10: 1151. 2019
Elevated Age-Related Cortical Iron, Ferritin and Amyloid Plaques in APP(swe)/PS1(Delta E9) Transgenic Mouse Model of Alzheimer's Disease
Svobodova, H; Kosn, D; Balazsiova, Z; Tanila, H; Miettinen, P O; Sierra, A; Vitovic, P; Wagner, A; Polak, S; Kopani, M. Physiological research 68 Suppl. 4: S445-S451. 2019
Intranasal insulin activates Akt2 signaling pathway in the hippocampus of wild-type but not in APP/PS1 Alzheimer model mice
Gabbouj, S; Natunen, T; Koivisto, H; Jokivarsi, K; Takalo, M; Marttinen, M; Wittrahm, R; Kemppainen, S; Naderi, R; Posado-Fernández, A; Ryhänen, S; Mäkinen, P; Paldanius, KMA; Doria, G; Poutiainen, P; Flores, O; Haapasalo, A; Tanila, H; Hiltunen, M. NEUROBIOLOGY OF AGING 2019; 75: 98-108. 2018
Increased cortical beta power and spike-wave discharges in middle-aged APP/PS1 mice
Jin, Nanxiang; Lipponen, Arto; Koivisto, Hennariikka; Gurevicius, Kestutis; Tanila, Heikki. NEUROBIOLOGY OF AGING 71: 127-141. 2018
Testing cognitive functions in rodent disease models: Present pitfalls and future perspectives
Tanila, Heikki. BEHAVIOURAL BRAIN RESEARCH 352: 23-27. 2018
Alzheimerin taudin patofysiologia - mitä uutta?
Tanila, Heikki; Hiltunen, Mikko; Myllykangas, Liisa. Duodecim 134 24: 2511-2518. 2018
Special lipid-based diets alleviate cognitive deficits in the APPswe/PS1dE9 transgenic mouse model of Alzheimer's disease independent of brain amyloid deposition
Koivisto H, Grimm MO, Rothhaar TL, Berkecz R, Lütjohann D D, Giniatullina R, Takalo M, Miettinen PO, Lahtinen HM, Giniatullin R, Penke B, Janáky T, Broersen LM, Hartmann T, Tanila H. JOURNAL OF NUTRITIONAL BIOCHEMISTRY 25 2: 157-169. 2014
Increased cortical and thalamic excitability in freely moving APPswe/PS1dE9 mice modeling epileptic activity associated with Alzheimer's disease
Gurevicius K, Lipponen A, Tanila H. CEREBRAL CORTEX (NEW YORK NY) 2013 May;23(5): 1148-58. 2013
Amyloid beta-induced neuronal hyperexcitability triggers progressive epilepsy
Minkeviciene R, Rheims S, Dobszay MB, Zilberter M, Hartikainen J, Fülöp L, Penke B, Zilberter Y, Harkany T, Pitkänen A, Tanila H. JOURNAL OF NEUROSCIENCE 29 11: 3453-3462. 2009
Neurocognitive aging: prior memories hinder new hippocampal encoding
Wilson IA, Gallagher M, Eichenbaum H, Tanila H, Tanila H. TRENDS IN NEUROSCIENCES 29 12: 662-670. 2006
Memantine improves spatial learning in a transgenic mouse model of Alzheimer¿s disease
Minkeviciene R, Banerjee P, Tanila H. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 311 2: 677-682. 2004

Tutkimusryhmät

Projektit

Avainsanat

Recommendations for Preclinical Testing of Treatments Against Alzheimer's Disease-Related Epileptiform Spikes in Transgenic Rodent Models

Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer's disease

Contribution of astrocytes to familial risk and clinical manifestation of schizophrenia

Medium-Chain Length Fatty Acids Enhance Aß Degradation by Affecting Insulin-Degrading Enzyme

Neuronal spreading and plaque induction of intracellular Aß and its disruption of Aß homeostasis

Phencyclidine-induced cognitive impairments in repeated touchscreen visual reversal learning tests in rats

Isoflurane affects brain functional connectivity in rats 1 month after exposure

Mikrogliasolut hoidon kohteeksi hermoston rappeumasairauksissa

Deficient astrocyte metabolism impairs glutamine synthesis and neurotransmitter homeostasis in a mouse model of Alzheimer's disease

Astrocyte remodeling in the beneficial effects of long-term voluntary exercise in Alzheimer's disease

Variant in NHLRC2 leads to increased hnRNP C2 in developing neurons and the hippocampus of a mouse model of FINCA disease

Response of spike-wave discharges in aged APP/PS1 Alzheimer model mice to antiepileptic, metabolic and cholinergic drugs

Orientation selective deep brain stimulation of the subthalamic nucleus in rats

Diabetic phenotype in mouse and humans reduces the number of microglia around ß-amyloid plaques

Iron-oxide minerals in the human tissues

Alzheimerin taudin amyloidikuormaa vähentävät lääkkeet käännekohdassa

Characterization of Epileptic Spiking Associated With Brain Amyloidosis in APP/PS1 Mice

Elevated Age-Related Cortical Iron, Ferritin and Amyloid Plaques in APP(swe)/PS1(Delta E9) Transgenic Mouse Model of Alzheimer's Disease

Intranasal insulin activates Akt2 signaling pathway in the hippocampus of wild-type but not in APP/PS1 Alzheimer model mice

Increased cortical beta power and spike-wave discharges in middle-aged APP/PS1 mice

Testing cognitive functions in rodent disease models: Present pitfalls and future perspectives

Alzheimerin taudin patofysiologia - mitä uutta?

Special lipid-based diets alleviate cognitive deficits in the APPswe/PS1dE9 transgenic mouse model of Alzheimer's disease independent of brain amyloid deposition

Increased cortical and thalamic excitability in freely moving APPswe/PS1dE9 mice modeling epileptic activity associated with Alzheimer's disease

Amyloid beta-induced neuronal hyperexcitability triggers progressive epilepsy

Neurocognitive aging: prior memories hinder new hippocampal encoding

Memantine improves spatial learning in a transgenic mouse model of Alzheimer¿s disease