Heikki Tanila

Alzheimerin taudin amyloidivasta-ainehoidot koetuksella

Tanila, Heikki; Tienari, Pentti. 2023. Duodecim. 139: 343-344

Incidence and Risk Factors of Transient Global Amnesia

Komulainen, Tiina; Bärlund, Venla; Tanila, Heikki; Koivisto, Anne; Jäkälä, Pekka. 2023. Neuroepidemiology. 57: 246-252

Most dystrophic neurites in the common 5xFAD Alzheimer mouse model originate from axon terminals

Mabrouk, R; Miettinen, PO; Tanila, H. 2023. Neurobiology of disease. 182:

Orientation selective stimulation with tetrahedral electrodes of the rat infralimbic cortex to indirectly target the amygdala

Gureviciene, Irina; Laakso, Hanne; Narvaez, Omar; Paasonen, Ekaterina; Lehto, Lauri; Gurevicius, Kestutis; Mangia, Silvia; Michaeli, Shalom; Gröhn, Olli; Sierra, Alejandra; Tanila, Heikki. 2023. Frontiers in neuroscience. 17: . 1147547

Activation of the hypoxia response protects mice from amyloid-β accumulation

Ollonen, Teemu; Kurkela, Margareta; Laitakari, Anna; Sakko, Samuli; Koivisto, Henna; Myllyharju, Johanna; Tanila, Heikki; Serpi, Raisa; Koivunen, Peppi. 2022. Cellular and molecular life sciences. 79: . 432

DAPI (4’,6-diamidino-2-phenylindole) Stains Compact Amyloid Plaques

Mabrouk, Rana; Gotkiewicz, Maria; Rauramaa, Tuomas; Tanila, Heikki. 2022. Journal of Alzheimer's disease. 88: 949-955

Event‐recurring multiband SWIFT functional MRI with 200‐ms temporal resolution during deep brain stimulation and isoflurane‐induced burst suppression in rat

Paasonen, Ekaterina; Paasonen, Jaakko; Lehto, Lauri J; Pirttimäki, Tiina; Laakso, Hanne; Wu, Lin; Ma, Jun; Idiyatullin, Djaudat; Tanila, Heikki; Mangia, Silvia; Michaeli, Shalom; Gröhn, Olli. 2022. Magnetic resonance in medicine. 87: 2872-2884

Human PSEN1 Mutant Glia Improve Spatial Learning and Memory in Aged Mice

Jäntti, Henna; Oksanen, Minna; Kettunen, Pinja; Manta, Stella; Mouledous, Lionel; Koivisto, Hennariikka; Ruuth, Johanna; Trontti, Kalevi; Dhungana, Hiramani; Keuters, Meike; Weert, Isabelle; Koskuvi, Marja; Hovatta, Iiris; Linden, Anni-Maija; Rampon, Claire; Malm, Tarja; Tanila, Heikki; Koistinaho, Jari; Rolova, Taisia. 2022. Cells. 11:

Kiistanalaiset beeta-amyloidivasta-aineet

Tienari, Pentti; Tanila, Heikki. 2022. Lääkärilehti. 77: 213

Novel Anti-Neuroinflammatory Properties of a Thiosemicarbazone–Pyridylhydrazone Copper(II) Complex

Choo, Xin Yi; McInnes, Lachlan E; Grubman, Alexandra; Wasielewska, Joanna M; Belaya, Irina; Burrows, Emma; Quek, Hazel; Martín, Jorge Cañas; Loppi, Sanna; Sorvari, Annika; Rait, Dzhessi; Powell, Andrew; Duncan, Clare; Liddell, Jeffrey R.; Tanila, Heikki; Polo, Jose M; Malm, Tarja; Kanninen, Katja M.; Donnelly, Paul S; White, Anthony R. 2022. International journal of molecular sciences. 23:

Orientation selective DBS of entorhinal cortex and medial septal nucleus modulates activity of rat brain areas involved in memory and cognition

Wu, Lin; Canna, Antonietta; Narvaez, Omar; Ma, Jun; Sang, Sheng; Lehto, Lauri J.; Sierra, Alejandra; Tanila, Heikki; Zhang, Yuan; Gröhn, Olli; Low, Walter C.; Filip, Pavel; Mangia, Silvia; Michaeli, Shalom. 2022. Scientific reports. 12: . 8565

Preclinical evaluation of drug treatment options for sleep‐related epileptiform spiking in Alzheimer's disease

Jin, Nanxiang; Gureviciene, Irina; Atalay, Aysu Naz; Häkli, Sara; Ziyatdinova, Sofya; Tanila, Heikki. 2022. Alzheimer's & dementia : Translational research & clinical interventions. 8:

Recommendations for Preclinical Testing of Treatments Against Alzheimer's Disease-Related Epileptiform Spikes in Transgenic Rodent Models

Jin, Nanxiang; Babiloni, Claudio; Drinkenburg, Wilhelmus H; Hajós, Mihály; Nygaard, Haakon B; Tanila, Heikki. 2022. Journal of Alzheimer's disease. 88: 849-865

Significance of developmental meningeal lymphatic dysfunction in experimental post-traumatic injury

Virenque, Anaïs; Koivisto, Hennariikka; Antila, Salli; Zub, Emma; Rooney, Erin Jane; Miszczuk, Diana; Müller, Adrian; Stoka, Enija; Marchi, Nicola; Alitalo, Kari; Tanila, Heikki; Noe, Francesco Mattia. 2022. Brain, behavior, & immunity : health. 23:

Whole-brain studies of spontaneous behavior in head-fixed rats enabled by zero echo time MB-SWIFT fMRI

Paasonen, Jaakko; Stenroos, Petteri; Laakso, Hanne; Pirttimäki, Tiina; Paasonen, Ekaterina; Salo, Raimo A.; Tanila, Heikki; Idiyatullin, Djaudat; Garwood, Michael; Michaeli, Shalom; Mangia, Silvia; Gröhn, Olli. 2022. Neuroimage. 250:

Contribution of astrocytes to familial risk and clinical manifestation of schizophrenia

Koskuvi, Marja; Lehtonen, ¦árka; Trontti, Kalevi; Keuters, Meike; Wu, Ying-Chieh; Koivisto, Hennariikka; Ludwig, Anastasia; Plotnikova, Lidiia; Virtanen, Pekka LJ; Räsänen, Noora; Kaipainen, Satu; Hyötyläinen, Ida; Dhungana, Hiramani; Giniatullina, Raisa; Ojansuu, Ilkka; Vaurio, Olli; Cannon, Tyrone D; Lönnqvist, Jouko; Therman, Sebastian; Suvisaari, Jaana; Kaprio, Jaakko; Lähteenvuo, Markku; Tohka, Jussi; Giniatullin, Rashid; Rivera, Claudio; Hovatta, Iiris; Tanila, Heikki; Tiihonen, Jari; Koi. 2021. Glia. 2022; 70: 650-660

Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer's disease

Andersen, Jens V.; Skotte, Niels H.; Christensen, Sofie K.; Polli, Filip S.; Shabani, Mohammad; Markussen, Kia H.; Haukedal, Henriette; Westi, Emil W.; Diaz-delCastillo, Marta; Sun, Ramon C.; Kohlmeier, Kristi A.; Schousboe, Arne; Gentry, Matthew S.; Tanila, Heikki; Freude, Kristine K.; Aldana, Blanca I.; Mann, Matthias; Waagepetersen, Helle S.. 2021. Cell death and disease. 12: 954

Isoflurane affects brain functional connectivity in rats 1 month after exposure

Stenroos, Petteri; Pirttimäki, Tiina; Paasonen, Jaakko; Paasonen, Ekaterina; Salo, Raimo A; Koivisto, Hennariikka; Natunen, Teemu; Mäkinen, Petra; Kuulasmaa, Teemu; Hiltunen, Mikko; Tanila, Heikki; Gröhn, Olli. 2021. Neuroimage. 234: 117987

Medium-Chain Length Fatty Acids Enhance Aß Degradation by Affecting Insulin-Degrading Enzyme

Mett, Janine; Lauer, Anna A; Janitschke, Daniel; Griebsch, Lea V; Theiss, Elena L; Grimm, Heike S; Koivisto, Hennariikka; Tanila, Heikki; Hartmann, Tobias; Grimm, Marcus OW. 2021. Cells. 10: 2941

Mikrogliasolut hoidon kohteeksi hermoston rappeumasairauksissa

Tienari, Pentti; Tanila, Heikki; Hiltunen, Mikko. 2021. Duodecim. 137: 1909-1911

Neuronal spreading and plaque induction of intracellular Aß and its disruption of Aß homeostasis

Roos, TT; Garcia, MG; Martinsson, I; Mabrouk, R; Israelsson, B; Deierborg, T; Kobro-Flatmoen, A; Tanila, H; Gouras, GK. 2021. Acta neuropathologica. 142: 669-687

Phencyclidine-induced cognitive impairments in repeated touchscreen visual reversal learning tests in rats

Savolainen, Katja; Ihalainen, Jouni; Hämäläinen, Elina; Tanila, Heikki; Forsberg, Markus M. 2021. Behavioural brain research. 404: 113057

Alzheimerin taudin amyloidikuormaa vähentävät lääkkeet käännekohdassa

Tanila, Heikki. 2020. Duodecim. 136: 2239-2245

Astrocyte remodeling in the beneficial effects of long-term voluntary exercise in Alzheimer's disease

Belaya, Irina; Ivanova, Mariia; Sorvari, Annika; Ilicic, Marina; Loppi, Sanna; Koivisto, Hennariikka; Varricchio, Alessandra; Tikkanen, Heikki; Walker, Frederick R; Atalay, Mustafa; Malm, Tarja; Grubman, Alexandra; Tanila, Heikki; Kanninen, Katja M. 2020. Journal of neuroinflammation. 17: 271

Deficient astrocyte metabolism impairs glutamine synthesis and neurotransmitter homeostasis in a mouse model of Alzheimer's disease

Andersen, Jens V; Christensen, Sofie K; Westi, Emil W; Diaz-delCastillo, Marta; Tanila, Heikki; Schousboe, Arne; Aldana, Blanca I; Waagepetersen, Helle S. 2020. Neurobiology of disease. 2021; 148: 105198

Diabetic phenotype in mouse and humans reduces the number of microglia around ß-amyloid plaques

Natunen, Teemu; Martiskainen, Henna; Marttinen, Mikael; Gabbouj, Sami; Koivisto, Hennariikka; Kemppainen, Susanna; Kaipainen, Satu; Takalo, Mari; Svobodová, Helena; Leppänen, Luukas; Kemiläinen, Benjam; Ryhänen, Simo; Kuulasmaa, Teemu: Rahunen, Eija: Juutinen, Sisko; Mäkinen, Petra; Miettinen, Pasi; Rauramaa, Tuomas; Pihlajamäki, Jussi; Haapasalo, Annakaisa; et al [incl. Leinonen, Ville; Tanila, Heikki; Hiltunen, Mikko]. 2020. Molecular neurodegeneration. 15: 66

Iron-oxide minerals in the human tissues

Svobodova, H; Kosnác, D; Tanila, H; Wagner, A; Trnka, M; Vitovic, P; Hlinkova, J; Vavrinsky, E; Ehrlich, H; Polák, ¦; Kopani, M. 2020. Biometals. 33: 1-13

Multi-band SWIFT enables quiet and artefact-free EEG-fMRI and awake fMRI studies in rat

Paasonen, J; Laakso, H; Pirttimäki, T; Stenroos, P; Salo, RA; Zhurakovskaya, E; Lehto, LJ; Tanila, H; Garwood, M; Michaeli, S; Idiyatullin, D; Mangia, S; Gröhn, O. 2020. Neuroimage. 206: 116338

Orientation selective deep brain stimulation of the subthalamic nucleus in rats

Lehto, Lauri; Canna, Antonietta; Wu, Lin; Sierra, Alejandra; Zhurakovskaya, E; Ma, Jun; Pearce, Clairice; Shaio, Maple; Filip, Pavel; Johnson, Matthew; Low, Walter; Gröhn, Olli; Tanila, Heikki; Mangia, Silvia; Michaeli, Shalom. 2020. Neuroimage. 213: 116750

Response of spike-wave discharges in aged APP/PS1 Alzheimer model mice to antiepileptic, metabolic and cholinergic drugs

Jin, Nanxiang; Ziyatdinova, Sofya; Gureviciene, Irina; Tanila, Heikki. 2020. Scientific reports. 10: 11851

Variant in NHLRC2 leads to increased hnRNP C2 in developing neurons and the hippocampus of a mouse model of FINCA disease

Hiltunen, Anniina E; Kangas, Salla M; Ohlmeier, Steffen; Pietilä, Ilkka; Hiltunen, Jori; Tanila, Heikki; McKerlie, Colin; Govindan, Subashika; Tuominen, Hannu; Kaarteenaho, Riitta; Hallman, Mikko; Uusimaa, Johanna; Hinttala, Reetta. 2020. Molecular medicine. 26: 123

Altered Insulin Signaling in Alzheimer's Disease Brain - Special Emphasis on PI3K-Akt Pathway

Gabbouj, Sami; Ryhanen, Simo; Marttinen, Mikael; Wittrahm, Rebekka; Takalo, Mari; Kemppainen, Susanna; Martiskainen, Henna; Tanila, Heikki; Haapasalo, Annakaisa; Hiltunen, Mikko; Natunen, Teemu. 2019. Frontiers in neuroscience. 13: 629

Characterization of Epileptic Spiking Associated With Brain Amyloidosis in APP/PS1 Mice

Gureviciene, I; Ishchenko, I; Ziyatdinova, S; Jin, N; Lipponen, A; Gurevicius, K; Tanila, H. 2019. Frontiers in neurology. 10: 1151

Deficiency of urokinase-type plasminogen activator and its receptor affects social behavior and increases seizure susceptibility

Kyyriäinen, J; Bolkvadze, T; Koivisto, H; Lipponen, A; Pérez, LO; Ekolle Ndode-Ekane, X; Tanila, H; Pitkänen, A. 2019. Epilepsy research. 151: 67-74

Elevated Age-Related Cortical Iron, Ferritin and Amyloid Plaques in APP(swe)/PS1(Delta E9) Transgenic Mouse Model of Alzheimer's Disease

Svobodova, H; Kosn, D; Balazsiova, Z; Tanila, H; Miettinen, P O; Sierra, A; Vitovic, P; Wagner, A; Polak, S; Kopani, M. 2019. Physiological research. 68: S445-S451

Impaired hippocampal-cortical coupling but preserved local synchrony during sleep in APP/PS1 mice modeling Alzheimer's disease

Zhurakovskaya, E; Ishchenko, I; Gureviciene, I; Aliev, R; Gröhn, O; Tanila, H. 2019. Scientific reports. 9: 5380

Loss of Cln5 leads to altered Gad1 expression and deficits in interneuron development in mice

Singh, Y; Leinonen, H; Fazaludeen, F; Jaronen, M; Guest, D; Buckley, N; Byts, N; Oksa, P; Jalkanen, K; Iqbal, I; Huuskonen, M; Savchenko, E; Keksa-Goldsteine, V; Chew, S; Myllyharju, J; Tanila, H; Ooi, L; Koistinaho, J; Kanninen, KM; Malm, T. 2019. Human molecular genetics. 28: 3309-3322

Metabolic state as a modulator of neural event-related potentials for food stimuli in an implicit association test

Lahtinen, Aapeli; Juvonen, Kristiina; Lapveteläinen, Anja; Kolehmainen, Marjukka; Lindholm, Mikko; Tanila, Heikki; Kantanen, Teuvo; Sinikallio, Sanna; Karhunen, Leila; Närväinen, Johanna. 2019. Physiology and behavior. 209: 112589

Null mutation in P4h-tm leads to decreased fear and anxiety and increased social behavior in mice

Leinonen, H; Koivisto, H; Lipponen, HR; Matilainen, A; Salo, AM; Dimova, EY; Hämäläinen, E; Stavén, S; Miettinen, P; Myllyharju, J; Koivunen, P; Tanila, H. 2019. Neuropharmacology. 153: 63-72

Progressive age-dependent motor impairment in human tau P301S overexpressing mice

Koivisto, H; Ytebrouck, E; Carmans, S; Naderi, R; Miettinen, PO; Roucourt, B; Tanila, H. 2019. Behavioural brain research. 376: 112158

Sleep-State Dependent Alterations in Brain Functional Connectivity under Urethane Anesthesia in a Rat Model of Early-Stage Parkinson's Disease

Zhurakovskaya, Ekaterina; Leikas, Juuso; Pirttimäki, Tiina; Casas Mon, Francesc; Gynther, Mikko; Aliev, Rubin; Rantamäki, Tomi; Tanila, Heikki; Forsberg, Markus M; Gröhn, Olli; Paasonen, Jaakko; Jalkanen, Aaro J. 2019. eNeuro. 6: 1-12

What electrophysiology tells us about Alzheimer's disease: a window into the synchronization and connectivity of brain neurons

Babiloni, C; Blinowska, K; Bonanni, L; Cichocki, A; De Haan, W; Del Percio, C; Dubois, B; Escudero, J; Fernández, A; Frisoni, G; Guntekin, B; Hajos, M; Hampel, H; Ifeachor, E; Kilborn, K; Kumar, S; Johnsen, K; Johannsson, M; Jeong, J; LeBeau, F; et al. (Incl. Tanila, H). 2019. Neurobiology of aging. 2020; 85: 58-73

Age-Dependent Decrease of Mitochondrial Complex II Activity in a Familial Mouse Model for Alzheimer's Disease

Emmerzaal, Tim L; Rodenburg, Richard J; Tanila, Heikki; Verweij, Vivienne; Kiliaan, Amanda J; Kozicz, Tamas. 2018. Journal of Alzheimer's disease. 66: 75-82

Alzheimerin taudin patofysiologia - mitä uutta?

Tanila, Heikki; Hiltunen, Mikko; Myllykangas, Liisa. 2018. Duodecim. 134: 2511-2518

Awake Rat Brain Functional Magnetic Resonance Imaging Using Standard Radio Frequency Coils and a 3D Printed Restraint Kit

Stenroos, Petteri; Paasonen, Jaakko; Salo, Raimo A; Jokivarsi, Kimmo; Shatillo, Artem; Tanila, Heikki; Gröhn, Olli. 2018. Frontiers in neuroscience. 12: 548

Collagen XIII is required for neuromuscular synapse regeneration and functional recovery after peripheral nerve injury

Zainul, Z; Heikkinen, A; Koivisto, H; Rautalahti, I; Kallio, M; Lin, S; Härönen, H; Norman, O; Rüegg, MA; Tanila, H; Pihlajaniemi, T. 2018. Journal of neuroscience. 38: 4243-4258

Genotoxicity of intermediate frequency magnetic fields in vitro and in vivo

Herrala, Mikko; Kumari, Kajal; Koivisto, Hennariikka; Luukkonen, Jukka; Tanila, Heikki; Naarala, Jonne; Juutilainen, Jukka. 2018. Environmental research. 167: 759-769

Impaired mitochondrial fatty acid synthesis leads to neurodegeneration in mice

Nair, Remya R; Koivisto, Henna; Jokivarsi, Kimmo; Miinalainen, Ilkka J; Autio, Kaija J; Manninen, Aki; Poutiainen, Pekka; Tanila, Heikki; Hiltunen, J Kalervo; Kastaniotis, Alexander J. 2018. Journal of neuroscience. 38: 9781-9800

Increased cortical beta power and spike-wave discharges in middle-aged APP/PS1 mice

Jin, Nanxiang; Lipponen, Arto; Koivisto, Hennariikka; Gurevicius, Kestutis; Tanila, Heikki. 2018. Neurobiology of aging. 71: 127-141

Intranasal insulin activates Akt2 signaling pathway in the hippocampus of wild-type but not in APP/PS1 Alzheimer model mice

Gabbouj, S; Natunen, T; Koivisto, H; Jokivarsi, K; Takalo, M; Marttinen, M; Wittrahm, R; Kemppainen, S; Naderi, R; Posado-Fernández, A; Ryhänen, S; Mäkinen, P; Paldanius, KMA; Doria, G; Poutiainen, P; Flores, O; Haapasalo, A; Tanila, H; Hiltunen, M. 2018. Neurobiology of aging. 2019; 75: 98-108

Loss of NRF-2 and PGC-1[alpha] genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration

Felszeghy, S; Viiri, J; Paterno, JJ; Hyttinen, JMT; Koskela, A; Chen, M; Leinonen, H; Tanila, H; Kivinen, N; Koistinen, A; Toropainen, E; Amadio, M; Smedowski, A; Reinisalo, M; Winiarczyk, M; Mackiewicz, J; Mutikainen, M; Ruotsalainen, AK; Kettunen, M; Jokivarsi, K; et al [Incl Kaarniranta, K; Kauppinen, A; Kinnunen, K; Levonen, A-L; Salminen, A; Tavi, P-P; Urtti, A]. 2018. Redox biology. 2019; 20: 1-12

Molecular Mechanisms of Synaptotoxicity and Neuroinflammation in Alzheimer's Disease

Marttinen, Mikael; Takalo, Mari; Natunen, Teemu; Wittrahm, Rebekka; Gabbouj, Sami; Kemppainen, Susanna; Leinonen, Ville; Tanila, Heikki; Haapasalo, Annakaisa; Hiltunen, Mikko. 2018. Frontiers in neurology. 12: 963

PPARß/DELTA-agonist GW0742 ameliorates dysfunction in fatty acid oxidation in PSEN1deltaE9 astrocytes

Konttinen, H; Gureviciene, I; Oksanen, M; Grubman, A; Loppi, S; Huuskonen, MT; Korhonen, P; Lampinen, R; Keuters, M; Belaya, I; Tanila, H; Kanninen, KM; Goldsteins, G; Landreth, G; Koistinaho, J; Malm, T. 2018. Glia. 2019; 67: 146-159

Spontaneous BOLD waves - A novel hemodynamic activity in Sprague-Dawley rat brain detected by functional magnetic resonance imaging

Shatillo, A; Lipponen, A; Salo, RA; Tanila, H; Verkhratsky, A; Giniatullin, R; Gröhn, OH. 2018. Journal of cerebral blood flow and metabolism. 2019; 39: 1949-1960

Testing cognitive functions in rodent disease models: Present pitfalls and future perspectives

Tanila, Heikki. 2018. Behavioural brain research. 352: 23-27

Tuning Neuromodulation Effects by Orientation Selective Deep Brain Stimulation in the Rat Medial Frontal Cortex

Lehto, Lauri J; Filip, Pavel; Laakso, Hanne; Sierra, Alejandra; Slopsema, Julia P; Johnson, Matthew D; Eberly, Lynn E; Low, Walter C; Gröhn, Olli; Tanila, Heikki; Mangia, Silvia; Michael, Shalom. 2018. Frontiers in neuroscience. 12: 899

Vision in laboratory rodents - Tools to measure it and implications for behavioral research

Leinonen, H; Tanila, H. 2018. Behavioural brain research. 352: 172-182

Alcohol consumption during adolescence is associated with reduced grey matter volumes

Heikkinen N, Niskanen E, Könönen M, Tolmunen T, Kekkonen V, Kivimäki P, Tanila H, Laukkanen E, Vanninen R. 2017. Addiction. 112: 604-613

Assessment of Health Risks of Intermediate Frequency Magnetic Fields

Herrala M, Kumari K, Blomme A, Khan MW, Koivisto H, Naarala J, Roivainen P, Tanila H, Viluksela M, Juutilainen J. Teoksessa: Eskola Hannu, Väisänen Outi, Viik Jari, Hyttinen Jari(toim.) , 2017. Joint Conference of the European Medical and Biological Engineering Conference (EMBEC) and the Nordic-Baltic Conference on Biomedical Engineering and Medical Physics (NBC), Tampere, Finland, June 2017. s. 719-722. Springer

Behavioral testing of mice exposed to intermediate frequency magnetic fields indicates mild memory impairment

Kumari K, Koivisto H, Viluksela M, Paldanius KMA, Marttinen M, Hiltunen M, Naarala J, Tanila H, Juutilainen J. 2017. PLoS ONE. 12: e0188880

Behavioural phenotypes in mice after prenatal and early postnatal exposure to intermediate frequency magnetic fields

Kumari, Kajal; Koivisto, Hennariikka; Myles, Capstick; Naarala, Jonne; Viluksela, Matti; Tanila, Heikki; Juutilainen, Jukka. 2017. Environmental research. 2018; 162: 27-34

Characteristics of CA1 place fields in a complex maze with multiple choice points

Tanila H, Ku S, Kloosterman F, Wilson MA. 2017. Hippocampus. 2018; 28: 81-96

Effects of intermediate frequency magnetic fields on male fertility indicators in mice

Kumari K, Capstick M, Cassara AM, Herrala M, Koivisto H, Naarala J, Tanila H, Viluksela M, Juutilainen J. 2017. Environmental research. 157: 64-70

Epilepsy in Models of Alzheimer's Disease

Tanila H, Pitkänen A. Teoksessa: Pitkänen A, Buckmaster PS, Galanopoulou AS, Moshé SL(toim.) , 2017. Models of Seizures and Epilepsy (Second Edition). s. 1021-1030. Elsevier

Retinal Degeneration In A Mouse Model Of CLN5 Disease Is Associated With Compromised Autophagy

Leinonen Henri, Keksa-Goldsteine Velta, Ragauskas Symantas, Kohlmann Philip, Signh Yajuvinder, Savchencko Ekaterina, Puranen Jooseppi, Malm Tarja, Kalesnykas Giedrius, Koistinaho Jari, Tanila Heikki, Kanninen Katja M. 2017. Scientific reports. 7: 1597

Alterations in cerebral cortical glucose and glutamine metabolism precedes amyloid plaques in the APPswe/PSEN1dE9 mouse model of Alzheimer's disease

Andersen JV, Christensen SK, Aldana BI, Nissen JD, Tanila H, Waagepetersen HS. 2016. Neurochemical research. 42: 1589-1598

Amyloid Plaques Show Binding Capacity of Exogenous Injected Amyloid-ß

Gureviciene Irina, Gurevicius Kestutis, Mugantseva Ekaterina, Kislin Mikhail, Khiroug Leonard, Tanila Heikki. 2016. Journal of Alzheimer's disease. 2017; 55: 147-157

Brain-Specific Basal and Novelty-Induced Alternations in PI3K-Akt and MAPK/ERK Signaling in a Middle-Aged AßPP/PS1 Mouse Model of Alzheimer's Disease

Guillot Florence, Kemppainen Susanna, Lavasseur Gregoire, Miettinen Pasi O, Laroche Serge, Tanila Heikki, Davis Sabrina. 2016. Journal of Alzheimer's disease. 51: 1157-1173

Chronic Pyruvate Supplementation Increases Exploratory Activity and Brain Energy Reserves in Young and Middle-Aged Mice

Koivisto H, Leinonen H, Puurula M, Hafez HS, Barrera GA, Stridh MH, Waagepetersen HS, Tiainen M, Soininen P, Zilberter Y, Tanila H.. 2016. Frontiers in aging neuroscience. 8: 1-14

Comparison of phencyclidine-induced spatial learning and memory deficits and reversal by sertindole and risperidone between Lister Hooded and Wistar rats

Ihalainen Jouni, Savolainen Katja, Tanila Heikki, Forsberg Markus M. 2016. Behavioural brain research. 305: 140-147

Global Functional Connectivity Differences between Sleep-Like States in Urethane Anesthetized Rats Measured by fMRI

Zhurakovskaya Ekaterina, Paasonen Jaakko, Shatillo Artem, Lipponen Arto, Salo Raimo, Aliev Raimo, Tanila Heikki, Gröhn Olli. 2016. PLoS ONE. 11: e0155343

Increased Epileptiform EEG Activity and Decreased Seizure Threshold in Arctic APP Transgenic Mouse Model of Alzheimer's Disease

Ziyatdinova Sofya, Rönnbäck Annica, Gurevicius Kestutis, Miszczuk Diana, Graff Caroline, Winblad Bengt, Pitkänen Asla, Tanila Heikki. 2016. Current alzheimer research. 13: 817-830

Lack of P4H-TM in mice results in age-related retinal and renal alterations

Leinonen H, Rossi M, Salo AM, Tiainen P, Hyvärinen J, Pitkänen M, Sormunen R, Miinalainen I, Zhang C, Soininen R, Kivirikko KI, Koskelainen A, Tanila H, Myllyharju J, Koivunen P. 2016. Human molecular genetics. 25: 3810-3823

Normal Amplitude of Electroretinography and Visual Evoked Potential Responses in AßPP/PS1 Mice

Leinonen Henri, Lipponen Arto, Gurevicius Kestutis, Tanila Heikki. 2016. Journal of Alzheimer's disease. 51: 21-26

SEPT8 modulates ß-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1

Kurkinen Kaisa MA, Marttinen Mikael, Turner Laura, Natunen Teemu, Mäkinen Petra, Haapalinna Fanni, Sarajärvi Timo, Gabbouj Sami, Kurki Mitja, Paananen Jussi, Koivisto Anne M, Rauramaa Tuomas, Leinonen Ville, Tanila Hanila, Soininen Hilkka, Lucas Fiona R, Haapasalo Annakaisa, Hiltunen Mikko. 2016. Journal of cell science. 129: 2224-2238

The role of BDNF in Alzheimer's disease

Tanila Heikki. 2016. Neurobiology of disease. 2017; 97: 114-118

Voiko terveiden henkilöiden muistia parantaa lääkkeillä?

Tanila Heikki. 2016. Duodecim. 132: 1857-1862

APP intracellular domain derived from amyloidogenic ß-and y-secretase cleavage regulates neprilysin expression

Grimm Marcus OW, Mett Janine, Stahlmann Christoph P, Grösgen Sven, Haupenthal Viola J, Blümel Tamara, Hundsdörfer Benjamin, Zimmer Valerie C, Mylonas Nadine T, Tanila Heikki, Müller Ulrike, Grimm Heike S, Hartmann Tobias. 2015. Frontiers in aging neuroscience. epub 19 May 2015:

Alzheimerin taudin parantava hoito viipyy yhä - onko amyloidiplakkihypoteesi väärä lähtökohta?

Tanila Heikki. 2015. Duodecim. 131: 243-248

Alzheimerin taudin patogeneesi

Tienari Pentti, Myllykangas Liisa, Polvikoski Tuomo, Tanila Heikki. Teoksessa: Timo Erkinjuntti, Anne Remes, Juha Rinne, Hilkka Soininen(toim.) , 2015. Muistisairaudet. 2. uud. p.. s. 102-120. Kustannus Oy Duodecim

Amyloid-ß and Tau Dynamics in Human Brain Interstitial Fluid in Patients with Suspected Normal Pressure Hydrocephalus

Herukka Sanna-Kaisa, Rummukainen Jaana, Ihalainen Jouni, von und zu Fraunberg Mikael, Koivisto Anne M, Nerg Ossi, Puli Lakshman K, Seppälä Toni T, Zetterberg Henrik, Pyykkö Okko T, Helisalmi Seppo, Tanila Heikki, Alafuzoff Irina, Hiltunen Mikko, Rinne Jaakko, Soininen Hilkka, Jääskeläinen Juha E, Leinonen Ville. 2015. Journal of Alzheimer's disease. 46: 261-269

Brain amyloidosis and BDNF deficiency have opposite effects on brain volumes in AßPP/PS1 mice both in vivo and ex vivo

Kärkkäinen Elisa, Lahtinen Hanna-Maija, Närväinen Johanna, Gröhn Olli, Tanila Heikki. 2015. Journal of Alzheimer's disease. 46: 926-946

Cerebral dopamine neurotrophic factor improves long-term memory in APP/PS1 transgenic mice modeling Alzheimer's disease as well as in wild-type mice

Kemppainen Susanna, Lindholm Päivi, Galli Emilia, Lahtinen Hanna-Maija, Koivisto Henna, Hämäläinen Elina, Saarma Mart, Taanila Heikki. 2015. Behavioural brain research. 291: 1-11

Deletion of Nuclear Factor kappa B p50 Subunit Decreases Inflammatory Response and Mildly Protects Neurons from Transient Forebrain Ischemia-induced Damage

Rolova Taisia, Dhungana Hiramani, Korhonen Paula, Valonen Piia, Kolosowska Natalia, Konttinen Henna, Kanninen Katja, Tanila Heikki, Malm Tarja, Koistinaho Jari. 2015. Aging and disease. [epub ahead of print 3 Dec 2015]: -

Kognitiivisten toimintojen neurobiologinen tausta

Tanila Heikki, Hänninen Tuomo. Teoksessa: Timo Erkinjuntti, Anne Remes, Juha Rinne, Hilkka Soininen(toim.) , 2015. Muistisairaudet. 2. uud. p.. s. 56-72. Kustannus Oy Duodecim

Meneekö muisti menopaussin myötä - voiko ikääntyvä nainen suojautua muistisairaudelta?

Remes Anne, Tanila Heikki, Hallikainen Merja. 2015. Duodecim. 131: 1499-1505

Opposing effects of APP/PS1 and TrkB.T1 genotypes on midbrain dopamine neurons and stimulated dopamine release in vivo

Kärkkäinen Elisa, Yavich Leonid, Miettinen Pasi O, Tanila Heikki. 2015. Brain research. 1622: 452-465

Reduction of epileptiform activity by valproic acid in a mouse model of Alzheimer's disease is not long-lasting after treatment discontinuation

Ziyatdinova Sofya, Viswanathan Jayashree, Hiltunen Mikko, Tanila Heikki, Pitkänen Asla. 2015. Epilepsy research. 112: 43-55

Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models

Natunen Teemu, Takalo Mari, Kemppainen Ssusanna, Leskelä Stina, Marttinen Mikael, Kurkinen Kaisa MA, Pursiheimo Juha-Pekka, Sarajärvi Timo, Viswanathan Jayashree, Gabbouj Sami, Solje Eino, Tahvanainen Eveliina, Pirttimäki Tiina, Kurki Mitja, Paananen Jussi, Rauramaa Tuomas, Miettinen Pasi, Mäkinen Petra, Leinonen Ville, Soininen Hilkka et al. 2015. Neurobiology of disease. 2016; 85: 187-205

Traumatic Brain Injury Increases the Expression of Nos1, Aß Clearance, and Epileptogenesis in APP/PS1 Mouse Model of Alzheimer's Disease

Miszczuk Diana, Debski Konrad J, Tanila Heikki, Lukasiuk Katarzyna, Pitkänen Asla. 2015. Molecular neurobiology. 2016; 53: 7010-7027

Urokinase-type plasminogen activator deficiency has little effect on seizure susceptibility and acquired epilepsy phenotype but reduces spontaneous exploration in mice

Rantala J, Kemppainen S, Ndode-Ekane XE, Lahtinen V, Bolkvadze Tamuna, Gurevicius K, Tanila H, Pitkänen A. 2015. Epilepsy and behavior. 42: 117-128

Behavioral and neuropathological consequences of transient global ischemia in APP/PS1 Alzheimer model mice

Kemppainen S, Hämäläinen E, Miettinen PO, Koistinaho J, Tanila H. 2014. Behavioural brain research. Volume 275, 15 December 2014: 15-26

Early Retinal Function Deficit without Prominent Morphological Changes in the R6/2 Mouse Model of Huntington's Disease

Ragauskas Symantas, Leinonen Henri, Puranen Jooseppi, Rönkkö Seppo, Nymark Soile, Gurevicius Kestutis, Lipponen Arto, Kontkanen Outi, Puoliväli Jukka, Tanila Heikki, Kalesnykas Giedrius. 2014. PLoS ONE. 9: e113317

High-fat diet increases tau expression in the brain of T2DM and AD mice independently of peripheral metabolic status

Takalo M, Haapasalo A, Martiskainen H, Kurkinen KM, Koivisto H, Miettinen P, Khandelwal VK, Kemppainen S, Kaminska D, Mäkinen P, Leinonen V, Pihlajamäki J, Soininen H, Laakso M, Tanila H, Hiltunen M. 2014. Journal of nutritional biochemistry. 25: 634-641

Increased y-Secretase Activity in Idiopathic Normal Pressure Hydrocephalus Patients with b-Amyloid Pathology

Laiterä T, Sarajärvi T, Haapasalo A, Puli L, Kauppinen T, Mäkinen P, Rauramaa T, Tanila H, Jääskeläinen JE, Alafuzoff I, Soininen H, Leinonen V, Hiltunen M. 2014. PLoS ONE. 3: 1-8

PS dependent APP cleavage regulates glucosylceramide synthase and is affected in Alzheimer's disease

Grimm MOW, Hundsdörfer B, Grösgen S, Mett J, Zimmer VC, Stahlmann CP, Haupenthal VJ, Rothhaar TL, Lehmann J, Pätzold A, Zinser EG, Tanila H, Shen J, Müller U, Grimm HS, Hartmann T. 2014. Cellular physiology and biochemistry. : 92-110

Short- and long-term habituation of auditory event-related potentials in the rat

Gurevicius Kestutis, Lipponen Arto, Minkeviciene Rimante, Tanila Heikki. 2014. F1000research. 2014, 2:182: [v2; ref status: indexed, http://f1000r.es/3dv]

Special lipid-based diets alleviate cognitive deficits in the APPswe/PS1dE9 transgenic mouse model of Alzheimer's disease independent of brain amyloid deposition

Koivisto H, Grimm MO, Rothhaar TL, Berkecz R, Lütjohann D D, Giniatullina R, Takalo M, Miettinen PO, Lahtinen HM, Giniatullin R, Penke B, Janáky T, Broersen LM, Hartmann T, Tanila H. 2014. Journal of nutritional biochemistry. 25: 157-169

Susceptibility to focal and global brain ischemia of Alzheimer mice displaying aß deposits: effect of immunoglobulin

Heikkinen Riikka, Malm Tarja, Heikkilä Janne, Muona Anu, Tanila Heikki, Koistinaho Milla, Koistinaho Jari. 2014. Aging and disease. 2014 Apr 1;5(2): 76-87

Amyloid precursor protein alpha- and beta-cleaved ectodomains exert opposing control of cholesterol homeostasis via SREBP2

Wang W, Mutka AL, Zmrzljak UP, Rozman D, Tanila H, Gylling H, Remes AM, Huttunen HJ, Ikonen E. 2013. Faseb journal. -: -

Complex regulation of acute and chronic neuroinflammatory responses in mouse models deficient for nuclear factor kappa B p50 subunit

Rolova T, Puli L, Magga J, Dhungana H, Kanninen K, Wojciehowski S, Salminen A, Tanila H, Koistinaho J, Malm T. 2013. Neurobiology of disease. [Epub ahead of print]: 16-29

Pharmacological Characterisation of a Structurally Novel &#945 (2C) -Adrenoceptor Antagonist ORM-10921 and its Effects in Neuropsychiatric Models

Sallinen J, Holappa J, Koivisto A, Kuokkanen K, Chapman H, Lehtimäki J, Piepponen P, Mijatovic J, Tanila H, Virtanen R, Sirviö J, Haapalinna A. 2013. Basic and clinical pharmacology and toxicology. 2013 Oct;113(4): 239-49

Plant sterols the better cholesterol in Alzheimer's Disease? A mechanistical study

Burg VK, Grimm HS, Rothhaar TL, Grösgen S, Hundsdörfer B, Haupenthal VJ, Zimmer VC, Mett J, Weingärtner O, Laufs U, Broersen LM, Tanila H, Vanmierlo T, Lutjohann D, Hartmann T, Grimm MOW. 2013. Journal of neuroscience. 33: 16072-16087

The Impact of Bdnf Gene Deficiency to the Memory Impairment and Brain Pathology of APPswe/PS1dE9 Mouse Model of Alzheimer's Disease

Rantamäki T, Kemppainen S, Autio H, Stavén S, Koivisto H, Kojima M, Antila H, Miettinen PO, Kärkkäinen E, Karpova N, Vesa L, Lindemann L, Hoener MC, Tanila H, Castrén E. 2013. PLoS ONE. 2013 Jul 3;8(7): e68722: -

Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer's disease

Vepsäläinen Saila, Koivisto Henna, Pekkarinen Elina, Mäkinen Petra, Dobson Gary, McDougall Gordon J, Stewart Derek, Haapasalo Annakaisa, Karjalainen Reijo O, Tanila Heikki, Hiltunen Mikko. 2012. Journal of nutritional biochemistry. 24: 360-370

Artificial Theta Stimulation Impairs Encoding of Contextual Fear Memory

Lipponen A, Woldemichael BT, Gurevicius K, Tanila H. 2012. PLoS ONE. 2012;7(11):e48506: --

Clusters of secretagogin-expressing neurons in the aged human olfactory tract lack terminal differentiation

Attems J, Alpar A, Spence L, McParland S, Heikenwalder M, Uhlén M, Tanila H, Hökfelt TG, Harkany T.. 2012. Proceedings of the National Academy of Sciences of the United States of America. 109: 6259-6264

Contribution of genetic and dietary insulin resistance to Alzheimer phenotype in APP/PS1 transgenic mice

Hiltunen M, Khandelwal VKM, Yaluri N, Tiilikainen T, Tusa M, Koivisto H, Krzisch M, Vepsäläinen S, Mäkinen P, Kemppainen S, Miettinen P, Haapasalo A, Soininen H, Laakso M, Tanila H. 2012. Journal of cellular and molecular medicine. 16: 1206-1222

Dietary energy substrates reverse early neuronal hyperactivity in a mouse model of Alzheimer's disease

Zilberter M, Ivanov A, Ziyatdinova S, Mukhtarov M, Malkov A, Alpár A, Tortoriello G, Botting CH, Fülöp L, Osypov AA, Pitkänen A, Tanila H, Harkany T, Zilberter Y. 2012. Journal of neurochemistry. : --

Effects of human intravenous immunoglobulin on amyloid pathology and neuroinflammation in a mouse model of Alzheimer's disease

Puli L, Pomeshchik Y, Olas K, Malm T, Koistinaho J, Tanila H. 2012. Journal of neuroinflammation. 2012 May 29;9:105: - -

Excitability in Freely Moving APPswe/PS1dE9 Mice Modeling Epileptic Activity

Gurevicius K, Lipponen A, Tanila H.. 2012. Cerebral cortex. 2012 May 10. [Epub ahead of print]: - -

Functional autoradiography shows unaltered cannabinoid CB1 receptor signalling in hippocampus and cortex of APP/PS1 transgenic mice

Kärkkäinen E, Tanila H, Laitinen JT. 2012. Cns and neurological disorders-drug targets. 11: 000-000

Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice

Kemppainen S, Rantamäki T, Jerónimo-Santos A, Lavasseur G, Autio H, Karpova N, Kärkkäinen E, Stavén S, Miranda HV, Outeiro TF, Diógenes MJ, Laroche S, Davis S, Sebastião AM, Castrén E, Tanila H.. 2012. Neurobiology of aging. 2012 Jun;33(6):1122.e23-39.: e23-39

Methylphenidate modifies overflow and presynaptic compartmentalization of dopamine via an &#945 -synuclein-dependent mechanism

Chadchankar Heramb, Ihalainen Jouni, Tanila Heikki, Yavich Leonid. 2012. Journal of pharmacology and experimental therapeutics. 341: 484-492

Neurochemical mapping of the human hippocampus reveals perisynaptic matrix around functional synapses in Alzheimer's disease

Lendvai D, Morawski M, Négyessy L, Gáti G, Jäger C, Baksa G, Glasz T, Attems J, Tanila H, Arendt T, Harkany T, Alpár A. 2012. Acta neuropathologica. : --

Transduced Wild-Type but Not P301S Mutated Human Tau Shows Hyperphosphorylation in Transgenic Mice Overexpressing A30P Mutated Human Alpha-Synuclein

Oksman M, Wisman LA, Jiang H, Miettinen P, Kirik D, Tanila H. 2012. Neurodegenerative diseases. 2012 Aug 30. [Epub ahead of print]: - -

Uncoupling of M1 muscarinic receptor/G-protein interaction by amyloid &#946 (1-42)

Janickova H, Rudajev V, Zimcik P, Jakubik J, Tanila H, El-Fakahany EE, Dolezal V. 2012. Neuropharmacology. 2012 Nov 30. [Epub ahead of print]: --

Wading pools, fading memories-place navigation in transgenic mouse models of Alzheimer's disease

Tanila Heikki. 2012. Frontiers in aging neuroscience. 2012; 4: 11: - -

Characterization of a novel transgenic rat carrying human tau with mutation P301L

Korhonen P, van Groen T, Thornell A, Kyrylenko S, Soininen M-L, Ojala J, Peltomaa E, Tanila H, Salminen A, Mandelkow EM, Soininen H. 2011. Neurobiology of aging. 32: 2314-2315

Decreased reuptake of dopamine in the dorsal striatum in the absence of alpha-synuclein

Chadchankar Heramb, Ihalainen Jouni, Tanila Heikki, Yavich Leonid. 2011. Brain research. 1382: 37-44

Effects of memantine and donepezil on cortical and hippocampal acetylcholine levels and object recognition memory in rats

Ihalainen Jouni, Sarajärvi Timo, Rasmusson Doug, Kemppainen Susanna, Keski-Rahkonen Pekka, Lehtonen Marko, Banerjee Pradeep K, Semba Kazue, Tanila Heikki. 2011. Neuropharmacology. 61: 891-899

From brain to food: Analysis of phosphatidylcholins, lyso-phosphatidylcholins and phosphatidylcholin¿plasmalogens derivates in Alzheimer's disease human post mortem brains and mice model via mass spectrometry

Grimm MO, Grösgen S, Riemenschneider M, Tanila H, Grimm HS, Hartmann T. 2011. Journal of chromatography a. : 7713-22

Molecular reorganization of endocannabinoid signalling in Alzheimer's disease

Mulder Jan, Zilberter Misha, Pasquaré Susana J, Alpár Alán, Schulte Gunnar, Ferreira Samira G, Köfalvi Attila, Martín-Moreno Ana M, Keimpema Erik, Tanila Heikki, Watanabe Masahiko, Mackie Ken, Hortobágyi Tibor, de Ceballos Maria L, Harkany Tibor. 2011. Brain. 134: 1041-1060

Multiple cellular and molecular mechanisms are involved in human A&#946 clearance by transplanted adult astrocytes.

Pihlaja R, Koistinaho J, Kauppinen R, Sandholm J, Tanila H, Koistinaho M. 2011. Glia. Nov;59(11): 1643-57

Spontaneous epileptiform discharges in a mouse model of Alzheimer's disease are suppressed by antiepileptic drugs that block sodium channels

Ziyatdinova Sofya, Gurevicius Kestutis, Kutchiashvili Nino, Bolkvadze Tamuna, Nissinen Jari, Tanila Heikki, Pitkänen Asla. 2011. Epilepsy research. 94: 75-85

WNT signaling in activated microglia is proinflammatory

Halleskog C, Mulder J, Dahlström J, Mackie K, Hortobágyi T, Tanila H, Kumar Puli L, Färber K, Harkany T & Schulte G. 2011. Glia. 59: 119-131

A novel delayed non-match to sample object recognition task that allows simultaneous in vivo microdialysis

Ihalainen J, Sarajärvi T, Kemppainen S, Keski-Rahkonen P, Lehtonen M & Tanila H. 2010. Journal of neuroscience methods. 189: 210 - 215

Alzheimerin taudin patogeneesi

Tienari P, Polvikoski T & Tanila H. Teoksessa: Erkinjuntti T, Rinne J & Soininen H (toim.)(toim.) , 2010. Muistisairaudet. s. 102-120. Duodecim

Blackcurrant (Ribes nigrum L.) neuroprotective potential: New results from the "BrainHealthFood" project

Karjalainen Reijo, Hiltunen Mikko, Vepsäläinen Saila, Törrönen Riitta, Saviranta Niina, Hilz Hauke, Bildstein Marie, McDougall Gordon, Stewart Derek, Mattila Pirjo, Tanila Heikki. 2010.

Functional cholinergic damage develops with amyloid accumulation in young adult APPswe/PS1dE9 transgenic mice

Machová E, Rudajev V, Smycková H, Koivisto H, Tanila H & Dolezal V. 2010. Neurobiology of disease. 38: 27-35

Human intravenous immunoglobulin provides protection against A&#946 toxicity by multiple mechanisms in a mouse model of Alzheimer's disease

Magga J, Puli L, Pihlaja R, Kanninen K, Neulamaa S, Malm T, Härtig W, Grosche J, Goldsteins G, Tanila H et al. 2010. Journal of neuroinflammation. 7: 90

Kognitiivisten toimintojen neurobiologinen tausta

Tanila H, Jäkälä P, Hänninen T &Ylinen A. Teoksessa: Erkinjuntti T, Rinne J & Soininen H (toim.)(toim.) , 2010. Muistisairaudet. s. 56-72. Duodecim

Lack of collagen XV impairs peripheral nerve maturation and, when combined with laminin-411 deficiency, leads to basement membrane abnormalities and sensorimotor dysfunction

Rasi K, Hurskainen M, Kallio M, Stavén S, Sormunen R, Heape AM, Avila RL, Kirschner D, Muona A, Tolonen U et al. 2010. Journal of neuroscience. 30: 14490-14501

Memantine lowers amyloid-beta peptide levels in neuronal cultures and in APP/PS1 transgenic mice

Alley GM, Bailey JA, Chen D, Ray B, Puli LK, Tanila H, Banerjee PK & Lahiri DK. 2010. Journal of neuroscience research. 88: 143-154

Mikä vie muistin Alzheimerin taudissa?

Tanila H. 2010. Erikoislääkäri. 20: 109-111

Aging and alpha-synuclein affect synaptic plasticity in the dentate gyrus

Gureviciene I, Gurevicius K, Tanila H. 2009. Journal of neural transmission. 116: 13-22

Amyloid beta-induced neuronal hyperexcitability triggers progressive epilepsy

Minkeviciene R, Rheims S, Dobszay MB, Zilberter M, Hartikainen J, Fülöp L, Penke B, Zilberter Y, Harkany T, Pitkänen A, Tanila H. 2009. Journal of neuroscience. 29: 3453-3462

Behavioural and neurochemical response of alpha-synuclein A30P transgenic mice to the effects of L-DOPA

Oksman M, Tanila H, Yavich L. 2009. Neuropharmacology. 56: 647-652

Discriminating accuracy of medial temporal lobe volumetry and fMRI in mild cognitive impairment

Jauhiainen AM, Pihlajamäki M, Tervo S, Niskanen E, Tanila H, Hänninen T, Vanninen RL, Soininen H, Soininen H. 2009. Hippocampus. 19: 166-175

Expression of interleukin-18 is increased in the brains of Alzheimer's disease patients

Ojala J, Alafuzoff I, Herukka SK, van Groen T, Tanila H, Pirttilä T, Pirttilä T. 2009. Neurobiology of aging. 30: 198-209

Fabrication and testing of polyimide-based microelectrode arrays for cortical mapping of evoked potentials

Myllymaa S, Myllymaa K, Korhonen H, Töyräs J, Jääskeläinen JE, Djupsund K, Tanila H, Lappalainen R. 2009. Biosensors and bioelectronics. 24: 3067-3072

Genetic ablation of tenascin-C expression leads to abnormal hippocampal CA1 structure and electrical activity in vivo

Gurevicius K, Kuang F, Stoenica L, Irintchev A, Gureviciene I, Dityatev A, Schachner M, Tanila H. 2009. Hippocampus. 19: 1232-1246

Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease

Kanninen K, Heikkinen R, Malm T, Rolova T, Kuhmonen S, Leinonen H, Ylä-Herttuala S, Tanila H, Levonen AL, Koistinaho M, Koistinaho J. 2009. Proceedings of the National Academy of Sciences of the United States of America. 106: 16505-16510

Memantine lowers amyloid-beta peptide levels in neuronal cultures and in APP/PS1 transgenic mice

Alley GM, Bailey JA, Chen D, Ray B, Puli LK, Tanila H, Banerjee PK, Lahiri DK. 2009. Journal of neuroscience research. 88: 143-154

Age-related decrease in stimulated glutamate release and vesicular glutamate transporters in APP/PS1 transgenic and wild-type mice

Minkeviciene R, Ihalainen J, Malm T, Matilainen O, Keksa-Goldsteine V, Goldsteins G, Iivonen H, Leguit N, Glennon J, Koistinaho J, Banerjee P, Tanila H. 2008. Journal of neurochemistry. 105: 584-594

Cognition-enhancing and anxiolytic effects of memantine

Minkeviciene R, Banerjee P, Tanila H. 2008. Neuropharmacology. 54: 1079-1085

Development of flexible microelectrode arrays for recording cortical surface field potentials

Myllymaa S, Myllymaa K, Korhonen H, Gureviciene I, Djupsund K, Tanila H, Lappalainen R. Teoksessa: (toim.) , 2008. 30th Annual International IEEE EMBS Conference. s. 3200-3203.

Impairment of muscarinic transmission in transgenic APPswe/PS1dE9 mice

Machová E, Jakubík J, Michal P, Oksman M, Iivonen H, Tanila H, Dolezal V. 2008. Neurobiology of aging. 29: 368-378

Increased expression of Abeta degrading enzyme IDE in the cortex of transgenic mice with Alzheimer's disease-like neuropathology

Vepsäläinen S, Hiltunen M, Helisalmi S, Wang J, van Groen T, Tanila H, Soininen H, Hiltunen M, Helisalmi S, Soininen H. 2008. Neuroscience letters. 438: 216-220

Nuclear factor erythroid 2-related factor 2 protects against beta amyloid

Kanninen K, Malm TM, Jyrkkänen HK, Goldsteins G, Keksa-Goldsteine V, Tanila H, Yamamoto M, Ylä-Herttuala S, Levonen AL, Koistinaho J. 2008. Molecular and cellular neuroscience. 39: 302-313

Parallel increase in p70 kinase activation and tau phosphorylation (S262) with Aß overproduction

Zhou XW , Tanila H , Pei JJ. 2008. Febs letters. 582: 159-164

Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology

Liu R, Zhou XW, Tanila H, Bjorkdahl C, Wang JZ, Guan ZZ, Cao Y, Gustafsson JÅ, Winblad B, Pei JJ. 2008. Journal of cellular and molecular medicine. 12: 241-257

Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A

Zhou XW, Gustafsson JA, Tanila H, Bjorkdahl C, Liu R, Winblad B, Pei JJ. 2008. Neurobiology of disease. 31: 386-394

Amyloid beta deposition is related to decreased glucose transporter-1 levels and hippocampal atrophy in brains of aged APP/PS1 mice

Hooijmans CR, Graven C, Dederen PJ, Tanila H, van Groen T, Kiliaan AJ. 2007. Brain research. 1181: 93-103

Changes in cerebral blood volume and amyloid pathology in aged Alzheimer APP/PS1 mice on a docosahexaenoic acid (DHA) diet or cholesterol enriched Typical Western Diet (TWD)

Hooijmans CR, Rutters F, Dederen PJ, Gambarota G, Veltien A, van Groen T, Broersen LM, Lütjohann D, Heerschap A, Tanila H, Kiliaan AJ. 2007. Neurobiology of disease. 28: 16-29

Increased fMRI responses during encoding in mild cognitive impairment

Hämäläinen A, Pihlajamäki M, Tanila H, Hänninen T, Niskanen E, Tervo S, Karjalainen PA, Vanninen RL, Soininen H, Soininen H, Tervo S. 2007. Neurobiology of aging. 28: 1889-1903

Increased hippocampal and cortical beta oscillations in mice deficient for the HNK-1 sulfotransferase

Gurevicius K, Gureviciene I, Sivukhina E, Irintchev A, Schachner M, Tanila H. 2007. Molecular and cellular neuroscience. 34: 189-198

Mechanics of self-stimulation and dopamine release in the nucleus accumbens

Yavich L, Tanila H. 2007. Neuroreport. 18: 1271-1274

Mobile phone radiation and the developing brain: behavioral and morphological effects in juvenile rats

Kumlin T, Iivonen H, Miettinen P, Juvonen A, van Groen T, Puranen L, Pitkäaho R, Juutilainen J, Tanila H. 2007. Radiation research. 168: 471-479

Pyrrolidine dithiocarbamate activates akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden

Malm TM, Iivonen H, Goldsteins G, Keksa-Goldsteine V, Ahtoniemi T, Kanninen K, Salminen A, Auriola S, van Groen T, Tanila H, Koistinaho J. 2007. Journal of neuroscience. 27: 3712-3721

Role of alpha-synuclein in synaptic glutamate release

Gureviciene I, Gurevicius K, Tanila H. 2007. Neurobiology of disease. 28: 83-89

Abnormal compartmentalization of norepinephrine in mouse dentate gyrus in alpha-synuclein knockout and A30P transgenic mice

Yavich L, Jäkälä P, Tanila H. 2006. Journal of neurochemistry. 99: 724-732

Abnormal compartmentalization of norepinephrine in mouse dentate gyrus in alpha-synuclein knockout and A30P trasgenic mice

Yavich L, Jäkälä P, Tanila H. 2006. Journal of neurochemistry. 99: 724-732

Brain reward in the absence of alpha-synuclein

Oksman M, Tanila H, Yavich L. 2006. Neuroreport. 17: 1191-1194

Effects of estradiol on spatial learning, hippocampal cytochrome P450 19, and estrogen alpha and beta mRNA levels in ovariectomized female mice

Iivonen S, Heikkinen T, Puoliväli J, Helisalmi S, Hiltunen M, Soininen H, Tanila H, Iivonen S, Helisalmi S, Hiltunen M, Soininen H. 2006. Neuroscience. 137: 1143-1152

Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice

Oksman M, Iivonen H, Hogyes E, Amtul Z, Penke B, Leenders I, Broersen L, Lütjohann D, Hartmann T, Tanila H. 2006. Neurobiology of disease. 23: 563-572

Miksi vanha ei muista?

Wilson I, Tanila H. 2006. Duodecim. 122: 1323-1329

Neurocognitive aging: prior memories hinder new hippocampal encoding

Wilson IA, Gallagher M, Eichenbaum H, Tanila H, Tanila H. 2006. Trends in neurosciences. 29: 662-670

Neurotrophins and dementia - keeping in touch

Castén E, Tanila H. 2006. Neuron. 51: 1-3

Non-fibrillar beta-amyloid abates spike-timing-dependent synaptic potentiation at excitatory synapses in layer 2/3 of the neocortex by targeting postsynaptic AMPA receptors

Shemer I, Holmgren C, Min R, Fülöp L, Zilberter M, Sousa KM, Farkas T, Härtig W, Penke B, Burnashev N, Tanila H, Zilberter Y, Harkany T. 2006. European journal of neuroscience. 23: 2035-2047

Thioflavins released from nanoparticles target fibrillar amyloid beta in the hippocampus of APP/PS1 transgenic mice

Siegemund T, Paulke B-R, Schmiedel H, Bordag N, Hoffmann A, Harkany T, Tanila H, Kacza J, Härtig W. 2006. International journal of developmental neuroscience. 24: 195-201

Age-associated alterations of hippocampal place cells are subregion specific

Wilson IA, Ikonen S, Gallagher M, Eichenbaum H, Tanila H. 2005. Journal of neuroscience. 25: 6877-6886

Cortical glutamate-dopamine interaction and ketamine-induced psychotic symptoms in man

Aalto S, Ihalainen J, Hirvonen J, Kajander J, Scheinin H, Tanila H, Någren K, Vilkman H, Gustafsson LL, Syvälahti E, Hietala J. 2005. Psychopharmacology. 182: 375-383

Distinct and overlapping fMRI activation networks for processing of novel identities and locations of objects

Pihlajamäki M, Tanila H, Könönen M, Hänninen T, Aronen HJ, Soininen H, Soininen H, könönen m. 2005. European journal of neuroscience. 22: 2095-2105

Locomotor activity and evoked dopamine release are reduced in mice overexpressing A30P-mutated alpha-synuclein

Yavich L, Oksman M, Tanila H, Kerokoski P, Hiltunen M, van Groen T, Puoliväli J, Männistö PT, García-Horsman A, MacDonald E, Beyreuther K, Hartmann T, Jäkälä P. 2005. Neurobiology of disease. 20: 303-313

Noradrenaline overflow in mouse dentate gyrus following locus coeruleus and natural stimulation: real-time monitoring by in vivo voltammetry

Yavich L, Jäkälä P, Tanila H, Yavich L. 2005. Journal of neurochemistry. 95: 641-650

Orexin loss in Huntington¿s disease

Petersen Å, Gil J, Maat-Schieman MLC, Björkqvist M, Tanila H, Araújo IM, Smith R, Popovic N, Wierup N, Norlén P, Li J-Y, Roos RAC, Sundler F, Mulder H, Brundin P. 2005. Human molecular genetics. 14: 39-47

Place cells of aged rats in two visually identical compartments

Wilson IA, Ikonen S, Gurevicius K, McMahan RW, Gallagher M, Eichenbaum H, Tanila H. 2005. Neurobiology of aging. 26: 1099-1106

Cognitive aging and the hippocampus: How old rats represent new environments

Wilson IA, Ikonen S, Gureviciene I, McMahan RW, Gallagher M, Eichenbaum H, Tanila H. 2004. Journal of neuroscience. 24: 3870-3878

Effects of NMDA-receptor antagonist treatment on c-fos expression in rat brain areas implicated in schizophrenia

Väisänen J, Ihalainen J, Tanila H, Castrén E. 2004. Cellular and molecular neurobiology. 24: 769-780

Effects of long-term ovariectomy and estrogen treatment on maze learning in aged mice

Heikkinen T, Puoliväli J, Tanila H. 2004. Experimental gerontology. 39: 1277-1283

Enhanced cortical and hippocampal neuronal excitability in mice deficient in the extracellular matrix glycoprotein tenascin-R

Gurevicius K, Gureviciene I, Valjakka A, Schachner M, Tanila H. 2004. Molecular and cellular neuroscience. 25: 515-523

Estrogen treatment improves spatial learning in APP + PS1 mice but does not affect beta amyloid accumulation and plaque formation

Heikkinen T, Kalesnykas G, Rissanen A, Tapiola T, Iivonen S, Wang J, Chaudhuri J, Tanila H, Miettinen R, Puoliväli J. 2004. Experimental neurology. 187: 105-117

In vivo regulation of dopamine and noradrenaline release by alpha2A-adrenoceptors in the mouse nucleus accumbens

Ihalainen JA, Tanila H. 2004. Journal of neurochemistry. 91: 49-56

Longitudinal observation on CSF Abeta42 levels in young to middle-aged amyloid precursor protein/presenilin-1 doubly transgenic mice

Liu L, Herukka S-K, Minkeviciene R, van Groen T, Tanila H. 2004. Neurobiology of disease. 17: 516-523

Memantine improves spatial learning in a transgenic mouse model of Alzheimer¿s disease

Minkeviciene R, Banerjee P, Tanila H. 2004. Journal of pharmacology and experimental therapeutics. 311: 677-682

Normal induction by accelerated decay of LTP in APP + PS1 transgenic mice

Gureviciene I, Ikonen S, Gurevicius K, Sarkaki A, van Groen T, Pussinen R, Ylinen A, Tanila H. 2004. Neurobiology of disease. 15: 188-195

Role of alfa-synuclein in presynaptic dopamine recruitment

Yavich L, Tanila H, Vepsäläinen S, Jäkälä P, Yavich L, Vepsäläinen S. 2004. Journal of neuroscience. 24: 11165-11170

Spermidine/spermine N1-acetyltransferase overexpression in mice induces hypoactivity and spatial learning impairment

Kaasinen SK, Oksman M, Alhonen L, Tanila H, Jänne J. 2004. Pharmacology biochemistry and behavior. 78: 35-45

Visual presentation of novel objects and new spatial arrangements of objects differentially activates the medial temporal lobe subareas in humans

Pihlajamäki M, Tanila H, Könönen M, Hänninen T, Hämäläinen A, Soininen H, Aronen HJ, Könönen M, Soininen H. 2004. European journal of neuroscience. 19: 1939-1949

Abeta levels in serum, CSF and brain, and cognitive deficits in APP + PS1 transgenic mice

Liu L, Tapiola T, Herukka S-K, Heikkilä M, Tanila H. 2003. Neuroreport. 14: 163-166

Altered auditory-evoked potentials in mice carrying mutated human amyloid precursor protein and presenilin-1 transgenes

Wang J, Ikonen S, Gurevicius K, van Groen T, Tanila H. 2003. Neuroscience. 116: 511-517

Encoding of novel picture pairs activates the perirhinal cortex: An fMRI study

Pihlajamäki M, Tanila H, Hänninen T, Könönen M, Mikkonen M, Jalkanen V, Partanen K, Aronen HJ, Soininen H. 2003. Hippocampus. 13: 67-80

Estrogen treatment alleviates NMDA-antagonist induced hippocampal LTP blockade and cognitive deficits in ovariectomized mice

Gureviciene I, Puoliväli J, Pussinen R, Wang J, Tanila H, Ylinen A. 2003. Neurobiology of learning and memory. 79: 72-80

Gender differences in the amount and deposition of amyloidbeta in APPswe and PS1 double transgenic mice

Wang J, Tanila H, Puoliväli J, Kadish I, van Groen T. 2003. Neurobiology of disease. 14: 318-327

Hypothermia in mice tested in Morris water maze

Iivonen H, Nurminen L, Harri M, Tanila H, Puoliväli J. 2003. Behavioural brain research. 141: 207-213

Place cell rigidity correlates with impaired spatial learning in aged rats

Wilson IA, Ikonen S, McMahan RW, Gallagher M, Eichenbaum H, Tanila H. 2003. Neurobiology of aging. 24: 297-305

Alpha2C-adrenoceptor mediated regulation of cortical EEG arousal

Puoliväli J, Björklund M, Holmberg M, Ihalainen JA, Scheinin M, Tanila H. 2002. Neuropharmacology. 43: 1305-1312

Alteration of cortical EEG in mice carrying mutated human APP transgene

Wang J, Ikonen S, Gurevicius K, van Groen T, Tanila H. 2002. Brain research. 943: 181-190

Cholinergic system regulation of spatial representation by the hippocampus

Ikonen S, McMahan R, Gallagher M, Eichenbaum H, Tanila H. 2002. Hippocampus. 12: 386-397

Effects of fimbria-fornix lesion and amyloid pathology on spatial learning and memory in transgenic APP+PS1 mice

Liu L, Ikonen S, Heikkinen T, Heikkilä M, Puoliväli J, van Groen T, Tanila H. 2002. Behavioural brain research. 134: 433-445

Effects of ovariectomy and estrogen treatment on learning and hippocampal neurotransmitters in mice

Heikkinen T, Puoliväli J, Liu L, Rissanen A, Tanila H. 2002. Hormones and behavior. 41: 22-32

Elevated levels of Abeeta1-40 and Abeeta1-42 do not alter the binding sites of nicotinic receptor subtypes in the brain of APPswe and PS1 double transgenic mice

Marutle A, Unger C, Hellström-Lindahl E, Wang J, Puoliväli J, Tanila H, Nordberg A, Zhang X. 2002. Neuroscience letters. 328: 269-272

Fimbria-fornix lesion does not affect APP levels and amyloid deposition in the hippocampus of APP+PS1 double transgenic mice

Liu L, Ikonen S, Tapiola T, Tanila H, van Groen T. 2002. Experimental neurology. 177: 565-574

Hippocampal Abeeta42 levels correlate with spatial memory deficit in APP and PS1 double transgenic mice

Puoliväli J, Wang J, Heikkinen T, Heikkilä M, Tapiola T, van GroenT, Tanila H. 2002. Neurobiology of disease. 9: 339-347

In vivo regulation of dopamine and noradrenaline release by alfa2A-adrenoceptors in the mouse prefrontal cortex

Ihalainen JA, Tanila H. 2002. European journal of neuroscience. 15: 1789-1794

The effects of long-term treatment with metrifonate, a cholinesterase inhibitor, on cholinergic activity, amyloid pathology, and cognitive function in APP and PS1 doubly transgenic mice

Liu L, Ikonen S, Heikkinen T, Tapiola T, van Groen T, Tanila H. 2002. Experimental neurology. 173: 196-204

Brain prolyl oligopeptidase activity is associated with neuronal damage rather than beta-amyloid accumulation

Laitinen KSM, van Groen T, Tanila H, Venäläinen J, Männistö PT, Alafuzoff I. 2001. Neuroreport. 12: 3309-3312

Effects of metrifonate on the hippocampal theta rhythm of freely moving intact and MS-lesioned mice

Ikonen S, Tanila H. 2001. Pharmacology biochemistry and behavior. 69: 165-172

Noradrenergic regulation of hippocampal place cells

Tanila H. 2001. Hippocampus. 11: 793-808

Spatial working memory improvement by an alpha2-adrenoceptor agonist dexmedetomidine is not mediated through alpha2C- adrenoceptor

Björklund M, Siverina I, Heikkinen T, Tanila H, Sallinen J, Scheinin M, Riekkinen P. 2001. Progress in neuro-psychopharmacology and biological psychiatry. 25: 1539-1554

alpha2c-Adrenoceptors modulate the effect of methylphenidate on response rateand discrimination accuracy in an operant test

Ihalainen JA, Tanila H, Scheinin M, Riekkinen P Jr. 2001. Brain research bulletin. 54: 553-557

Verbal fluency activates the left medial temporal lobe: a functional magnetic resonance imaging study

Pihlajamäki M, Tanila H, Hänninen T, Könönen M, Laakso M, Partanen K, Soininen H, Aronen HJ. 2000. Annals of neurology. 47: 470-476

Hippocampal place cells can develop distinct representations of two visually identical environments

Tanila H. 1999. Hippocampus. 9: 235-246

Role of alfa2C-adrenoceptor subtype in spatial working memory as revealed by mice with targeted disruption of the alfa2C-adrenoceptor gene

Tanila H, Mustonen K, Sallinen J, Scheinin M, Riekkinen P Jr. 1999. European journal of neuroscience. 11: 599-603

The hippocampus, memory, and place cells: is it spatial memory or a memory space?

Eichenbaum H, Dudchenko P, Wood E, Shapiro M, Tanila H. 1999. Neuron. 23: 209-226

Vanhenevat aivot, huononeva muisti

Tanila H. 1999. KEMIA-KEMI. 26: 170-174

Abnormal hippocampal spatial representations in alfaCaMKII T286A and CREBalfa delta- Mice

Cho YH, Giese KP, Tanila H, Silva AJ, Eichenbaum H. 1998. Science. 279: 867-869

Cognitive changes in mice following moderate MPTP exposure

Tanila H, Björklund M, Riekkinen P Jr. 1998. Brain research bulletin. 45: 577-582

Unique features in the processing of spatial information by the aged hippocampus as shown by place cell recording studies: a response to Peter Rapp¿s commentary "Representational organization in the aged hippocampus

Tanila H. 1998. Hippocampus

Brain aging:changes in the nature of information coding by the hippocampus

Tanila H, Shapiro M, Gallagher M, Eichenbaum H. 1997. Journal of neuroscience. 17: 5155-5166

Brain aging:impaired coding of novel environmental cues

Tanila H, Sipilä P, Shapiro M, Eichenbaum H. 1997. Journal of neuroscience. 17: 5167-5174

Cues that hippocampal place cells encode: dynamic and hierarchical representation of local and distal stimuli

Shapiro ML, Tanila H, Eichenbaum H. 1997. Hippocampus. 7: 624-642

Discordance of spatial representation in ensembles of hippocampal place cells

Tanila H, Shapiro ML, Eichenbaum H. 1997. Hippocampus. 7: 613-623

Leikkaus, joka vei muistin

Tanila H. 1996. Duodecim. 112: 1553-1557

Tarkenna hakuasi

Tutkimusryhmät

Projektit

Avainsanat

Alzheimerin taudin amyloidivasta-ainehoidot koetuksella

Incidence and Risk Factors of Transient Global Amnesia

Most dystrophic neurites in the common 5xFAD Alzheimer mouse model originate from axon terminals

Orientation selective stimulation with tetrahedral electrodes of the rat infralimbic cortex to indirectly target the amygdala

Activation of the hypoxia response protects mice from amyloid-β accumulation

DAPI (4’,6-diamidino-2-phenylindole) Stains Compact Amyloid Plaques

Event‐recurring multiband SWIFT functional MRI with 200‐ms temporal resolution during deep brain stimulation and isoflurane‐induced burst suppression in rat

Human PSEN1 Mutant Glia Improve Spatial Learning and Memory in Aged Mice

Kiistanalaiset beeta-amyloidivasta-aineet

Novel Anti-Neuroinflammatory Properties of a Thiosemicarbazone–Pyridylhydrazone Copper(II) Complex

Orientation selective DBS of entorhinal cortex and medial septal nucleus modulates activity of rat brain areas involved in memory and cognition

Preclinical evaluation of drug treatment options for sleep‐related epileptiform spiking in Alzheimer's disease

Recommendations for Preclinical Testing of Treatments Against Alzheimer's Disease-Related Epileptiform Spikes in Transgenic Rodent Models

Significance of developmental meningeal lymphatic dysfunction in experimental post-traumatic injury

Whole-brain studies of spontaneous behavior in head-fixed rats enabled by zero echo time MB-SWIFT fMRI

Contribution of astrocytes to familial risk and clinical manifestation of schizophrenia

Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer's disease

Isoflurane affects brain functional connectivity in rats 1 month after exposure

Medium-Chain Length Fatty Acids Enhance Aß Degradation by Affecting Insulin-Degrading Enzyme

Mikrogliasolut hoidon kohteeksi hermoston rappeumasairauksissa

Neuronal spreading and plaque induction of intracellular Aß and its disruption of Aß homeostasis

Phencyclidine-induced cognitive impairments in repeated touchscreen visual reversal learning tests in rats

Alzheimerin taudin amyloidikuormaa vähentävät lääkkeet käännekohdassa

Astrocyte remodeling in the beneficial effects of long-term voluntary exercise in Alzheimer's disease

Deficient astrocyte metabolism impairs glutamine synthesis and neurotransmitter homeostasis in a mouse model of Alzheimer's disease

Diabetic phenotype in mouse and humans reduces the number of microglia around ß-amyloid plaques

Iron-oxide minerals in the human tissues

Multi-band SWIFT enables quiet and artefact-free EEG-fMRI and awake fMRI studies in rat

Orientation selective deep brain stimulation of the subthalamic nucleus in rats

Response of spike-wave discharges in aged APP/PS1 Alzheimer model mice to antiepileptic, metabolic and cholinergic drugs

Variant in NHLRC2 leads to increased hnRNP C2 in developing neurons and the hippocampus of a mouse model of FINCA disease

Altered Insulin Signaling in Alzheimer's Disease Brain - Special Emphasis on PI3K-Akt Pathway

Characterization of Epileptic Spiking Associated With Brain Amyloidosis in APP/PS1 Mice

Deficiency of urokinase-type plasminogen activator and its receptor affects social behavior and increases seizure susceptibility

Elevated Age-Related Cortical Iron, Ferritin and Amyloid Plaques in APP(swe)/PS1(Delta E9) Transgenic Mouse Model of Alzheimer's Disease

Impaired hippocampal-cortical coupling but preserved local synchrony during sleep in APP/PS1 mice modeling Alzheimer's disease

Loss of Cln5 leads to altered Gad1 expression and deficits in interneuron development in mice

Metabolic state as a modulator of neural event-related potentials for food stimuli in an implicit association test

Null mutation in P4h-tm leads to decreased fear and anxiety and increased social behavior in mice

Progressive age-dependent motor impairment in human tau P301S overexpressing mice

Sleep-State Dependent Alterations in Brain Functional Connectivity under Urethane Anesthesia in a Rat Model of Early-Stage Parkinson's Disease

What electrophysiology tells us about Alzheimer's disease: a window into the synchronization and connectivity of brain neurons

Age-Dependent Decrease of Mitochondrial Complex II Activity in a Familial Mouse Model for Alzheimer's Disease

Alzheimerin taudin patofysiologia - mitä uutta?

Awake Rat Brain Functional Magnetic Resonance Imaging Using Standard Radio Frequency Coils and a 3D Printed Restraint Kit

Collagen XIII is required for neuromuscular synapse regeneration and functional recovery after peripheral nerve injury

Genotoxicity of intermediate frequency magnetic fields in vitro and in vivo

Impaired mitochondrial fatty acid synthesis leads to neurodegeneration in mice

Increased cortical beta power and spike-wave discharges in middle-aged APP/PS1 mice

Intranasal insulin activates Akt2 signaling pathway in the hippocampus of wild-type but not in APP/PS1 Alzheimer model mice

Loss of NRF-2 and PGC-1[alpha] genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration

Molecular Mechanisms of Synaptotoxicity and Neuroinflammation in Alzheimer's Disease

PPARß/DELTA-agonist GW0742 ameliorates dysfunction in fatty acid oxidation in PSEN1deltaE9 astrocytes

Spontaneous BOLD waves - A novel hemodynamic activity in Sprague-Dawley rat brain detected by functional magnetic resonance imaging

Testing cognitive functions in rodent disease models: Present pitfalls and future perspectives

Tuning Neuromodulation Effects by Orientation Selective Deep Brain Stimulation in the Rat Medial Frontal Cortex

Vision in laboratory rodents - Tools to measure it and implications for behavioral research

Alcohol consumption during adolescence is associated with reduced grey matter volumes

Assessment of Health Risks of Intermediate Frequency Magnetic Fields

Behavioral testing of mice exposed to intermediate frequency magnetic fields indicates mild memory impairment

Behavioural phenotypes in mice after prenatal and early postnatal exposure to intermediate frequency magnetic fields

Characteristics of CA1 place fields in a complex maze with multiple choice points

Effects of intermediate frequency magnetic fields on male fertility indicators in mice

Epilepsy in Models of Alzheimer's Disease

Retinal Degeneration In A Mouse Model Of CLN5 Disease Is Associated With Compromised Autophagy

Alterations in cerebral cortical glucose and glutamine metabolism precedes amyloid plaques in the APPswe/PSEN1dE9 mouse model of Alzheimer's disease

Amyloid Plaques Show Binding Capacity of Exogenous Injected Amyloid-ß

Brain-Specific Basal and Novelty-Induced Alternations in PI3K-Akt and MAPK/ERK Signaling in a Middle-Aged AßPP/PS1 Mouse Model of Alzheimer's Disease

Chronic Pyruvate Supplementation Increases Exploratory Activity and Brain Energy Reserves in Young and Middle-Aged Mice

Comparison of phencyclidine-induced spatial learning and memory deficits and reversal by sertindole and risperidone between Lister Hooded and Wistar rats

Global Functional Connectivity Differences between Sleep-Like States in Urethane Anesthetized Rats Measured by fMRI

Increased Epileptiform EEG Activity and Decreased Seizure Threshold in Arctic APP Transgenic Mouse Model of Alzheimer's Disease

Lack of P4H-TM in mice results in age-related retinal and renal alterations

Normal Amplitude of Electroretinography and Visual Evoked Potential Responses in AßPP/PS1 Mice

SEPT8 modulates ß-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1