HEIKKI TANILA

Yhteystiedot

Avainsanat

Opetustehtävät

Tutkimusryhmät - UEF

• 
  Muistin neurobiologia
• 
  Neuro-Innovation

Julkaisut

• Jin, Nanxiang; Babiloni, Claudio; Drinkenburg, Wilhelmus H; Hajós, Mihály; Nygaard, Haakon B; Tanila, Heikki. 2022. Recommendations for Preclinical Testing of Treatments Against Alzheimer's Disease-Related Epileptiform Spikes in Transgenic Rodent Models Journal of Alzheimer's disease [Uncorrected author proof]: 1-16. 2022
• Koskuvi, Marja; Lehtonen, Šárka; Trontti, Kalevi; Keuters, Meike; Wu, Ying-Chieh; Koivisto, Hennariikka; Ludwig, Anastasia; Plotnikova, Lidiia; Virtanen, Pekka LJ; Räsänen, Noora; Kaipainen, Satu; Hyötyläinen, Ida; Dhungana, Hiramani; Giniatullina, Raisa; Ojansuu, Ilkka; Vaurio, Olli; Cannon, Tyrone D; Lönnqvist, Jouko; Therman, Sebastian; Suvisaari, Jaana; Kaprio, Jaakko; Lähteenvuo, Markku; Toh. 2021. Contribution of astrocytes to familial risk and clinical manifestation of schizophrenia Glia 2022; 70 4: 650-660. 2021
• Mett, Janine; Lauer, Anna A; Janitschke, Daniel; Griebsch, Lea V; Theiss, Elena L; Grimm, Heike S; Koivisto, Hennariikka; Tanila, Heikki; Hartmann, Tobias; Grimm, Marcus OW. 2021. Medium-Chain Length Fatty Acids Enhance Aß Degradation by Affecting Insulin-Degrading Enzyme Cells 10 11: 2941. 2021
• Roos, TT; Garcia, MG; Martinsson, I; Mabrouk, R; Israelsson, B; Deierborg, T; Kobro-Flatmoen, A; Tanila, H; Gouras, GK. 2021. Neuronal spreading and plaque induction of intracellular Aß and its disruption of Aß homeostasis Acta neuropathologica 142 4: 669-687. 2021
• Savolainen, Katja; Ihalainen, Jouni; Hämäläinen, Elina; Tanila, Heikki; Forsberg, Markus M. 2021. Phencyclidine-induced cognitive impairments in repeated touchscreen visual reversal learning tests in rats Behavioural brain research 404: 113057. 2021
• Stenroos, Petteri; Pirttimäki, Tiina; Paasonen, Jaakko; Paasonen, Ekaterina; Salo, Raimo A; Koivisto, Hennariikka; Natunen, Teemu; Mäkinen, Petra; Kuulasmaa, Teemu; Hiltunen, Mikko; Tanila, Heikki; Gröhn, Olli. 2021. Isoflurane affects brain functional connectivity in rats 1 month after exposure Neuroimage 234: 117987. 2021
• Tienari, Pentti; Tanila, Heikki; Hiltunen, Mikko. 2021. Mikrogliasolut hoidon kohteeksi hermoston rappeumasairauksissa Duodecim 137 18: 1909-1911. 2021
• Andersen, Jens V.; Skotte, Niels H.; Christensen, Sofie K.; Polli, Filip S.; Shabani, Mohammad; Markussen, Kia H.; Haukedal, Henriette; Westi, Emil W.; Diaz-delCastillo, Marta; Sun, Ramon C.; Kohlmeier, Kristi A.; Schousboe, Arne; Gentry, Matthew S.; Tanila, Heikki; Freude, Kristine K.; Aldana, Blanca I.; Mann, Matthias; Waagepetersen, Helle S.. 2021. Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer's disease Cell death and disease 12 11: 954. 2021
• Natunen, Teemu; Martiskainen, Henna; Marttinen, Mikael; Gabbouj, Sami; Koivisto, Hennariikka; Kemppainen, Susanna; Kaipainen, Satu; Takalo, Mari; Svobodová, Helena; Leppänen, Luukas; Kemiläinen, Benjam; Ryhänen, Simo; Kuulasmaa, Teemu: Rahunen, Eija: Juutinen, Sisko; Mäkinen, Petra; Miettinen, Pasi; Rauramaa, Tuomas; Pihlajamäki, Jussi; Haapasalo, Annakaisa; et al [incl. Leinonen, Ville; Tanila, H. 2020. Diabetic phenotype in mouse and humans reduces the number of microglia around ß-amyloid plaques Molecular neurodegeneration 15: 66. 2020
• Tanila, Heikki. 2020. Alzheimerin taudin amyloidikuormaa vähentävät lääkkeet käännekohdassa Duodecim 136 20: 2239-2245. 2020
• Svobodova, H; Kosnác, D; Tanila, H; Wagner, A; Trnka, M; Vitovic, P; Hlinkova, J; Vavrinsky, E; Ehrlich, H; Polák, Š; Kopani, M. 2020. Iron-oxide minerals in the human tissues Biometals 33 1: 1-13. 2020
• Hiltunen, Anniina E; Kangas, Salla M; Ohlmeier, Steffen; Pietilä, Ilkka; Hiltunen, Jori; Tanila, Heikki; McKerlie, Colin; Govindan, Subashika; Tuominen, Hannu; Kaarteenaho, Riitta; Hallman, Mikko; Uusimaa, Johanna; Hinttala, Reetta. 2020. Variant in NHLRC2 leads to increased hnRNP C2 in developing neurons and the hippocampus of a mouse model of FINCA disease Molecular medicine 26 1: 123. 2020
• Lehto, Lauri; Canna, Antonietta; Wu, Lin; Sierra, Alejandra; Zhurakovskaya, E; Ma, Jun; Pearce, Clairice; Shaio, Maple; Filip, Pavel; Johnson, Matthew; Low, Walter; Gröhn, Olli; Tanila, Heikki; Mangia, Silvia; Michaeli, Shalom. 2020. Orientation selective deep brain stimulation of the subthalamic nucleus in rats Neuroimage 213: 116750. 2020
• Jin, Nanxiang; Ziyatdinova, Sofya; Gureviciene, Irina; Tanila, Heikki. 2020. Response of spike-wave discharges in aged APP/PS1 Alzheimer model mice to antiepileptic, metabolic and cholinergic drugs Scientific reports 10 1: 11851. 2020
• Belaya, Irina; Ivanova, Mariia; Sorvari, Annika; Ilicic, Marina; Loppi, Sanna; Koivisto, Hennariikka; Varricchio, Alessandra; Tikkanen, Heikki; Walker, Frederick R; Atalay, Mustafa; Malm, Tarja; Grubman, Alexandra; Tanila, Heikki; Kanninen, Katja M. 2020. Astrocyte remodeling in the beneficial effects of long-term voluntary exercise in Alzheimer's disease Journal of neuroinflammation 17 1: 271. 2020
• Andersen, Jens V; Christensen, Sofie K; Westi, Emil W; Diaz-delCastillo, Marta; Tanila, Heikki; Schousboe, Arne; Aldana, Blanca I; Waagepetersen, Helle S. 2020. Deficient astrocyte metabolism impairs glutamine synthesis and neurotransmitter homeostasis in a mouse model of Alzheimer's disease Neurobiology of disease 2021; 148: 105198. 2020
• Svobodova, H; Kosn, D; Balazsiova, Z; Tanila, H; Miettinen, P O; Sierra, A; Vitovic, P; Wagner, A; Polak, S; Kopani, M. 2019. Elevated Age-Related Cortical Iron, Ferritin and Amyloid Plaques in APP(swe)/PS1(Delta E9) Transgenic Mouse Model of Alzheimer's Disease Physiological research 68 Suppl. 4: S445-S451. 2019
• Gureviciene, I; Ishchenko, I; Ziyatdinova, S; Jin, N; Lipponen, A; Gurevicius, K; Tanila, H. 2019. Characterization of Epileptic Spiking Associated With Brain Amyloidosis in APP/PS1 Mice Frontiers in neurology 10: 1151. 2019
• Tanila, Heikki; Hiltunen, Mikko; Myllykangas, Liisa. 2018. Alzheimerin taudin patofysiologia - mitä uutta? Duodecim 134 24: 2511-2518. 2018
• Tanila, Heikki. 2018. Testing cognitive functions in rodent disease models: Present pitfalls and future perspectives BEHAVIOURAL BRAIN RESEARCH 352: 23-27. 2018
• Jin, Nanxiang; Lipponen, Arto; Koivisto, Hennariikka; Gurevicius, Kestutis; Tanila, Heikki. 2018. Increased cortical beta power and spike-wave discharges in middle-aged APP/PS1 mice NEUROBIOLOGY OF AGING 71: 127-141. 2018
• Gabbouj, S; Natunen, T; Koivisto, H; Jokivarsi, K; Takalo, M; Marttinen, M; Wittrahm, R; Kemppainen, S; Naderi, R; Posado-Fernández, A; Ryhänen, S; Mäkinen, P; Paldanius, KMA; Doria, G; Poutiainen, P; Flores, O; Haapasalo, A; Tanila, H; Hiltunen, M. 2018. Intranasal insulin activates Akt2 signaling pathway in the hippocampus of wild-type but not in APP/PS1 Alzheimer model mice NEUROBIOLOGY OF AGING 2019; 75: 98-108. 2018
• Koivisto H, Grimm MO, Rothhaar TL, Berkecz R, Lütjohann D D, Giniatullina R, Takalo M, Miettinen PO, Lahtinen HM, Giniatullin R, Penke B, Janáky T, Broersen LM, Hartmann T, Tanila H. 2014. Special lipid-based diets alleviate cognitive deficits in the APPswe/PS1dE9 transgenic mouse model of Alzheimer's disease independent of brain amyloid deposition. JOURNAL OF NUTRITIONAL BIOCHEMISTRY 25 2: 157-169. 2014
• Gurevicius K, Lipponen A, Tanila H. 2013. Increased cortical and thalamic excitability in freely moving APPswe/PS1dE9 mice modeling epileptic activity associated with Alzheimer's disease. CEREBRAL CORTEX (NEW YORK NY) 2013 May;23(5): 1148-58. 2013
• Minkeviciene R, Rheims S, Dobszay MB, Zilberter M, Hartikainen J, Fülöp L, Penke B, Zilberter Y, Harkany T, Pitkänen A, Tanila H. 2009. Amyloid beta-induced neuronal hyperexcitability triggers progressive epilepsy. JOURNAL OF NEUROSCIENCE 29 11: 3453-3462. 2009
• Wilson IA, Gallagher M, Eichenbaum H, Tanila H, Tanila H. 2006. Neurocognitive aging: prior memories hinder new hippocampal encoding TRENDS IN NEUROSCIENCES 29 12: 662-670. 2006
• Minkeviciene R, Banerjee P, Tanila H. 2004. Memantine improves spatial learning in a transgenic mouse model of Alzheimer¿s disease. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 311 2: 677-682. 2004