Jari Tiihonen

An international research agenda for clozapine-resistant schizophrenia

Luykx, Jurjen J.; Gonzalez-Diaz, Jairo M.; Guu, Ta Wei; van der Horst, Marte Z.; van Dellen, Edwin; Boks, Marco P.; Guloksuz, Sinan; DeLisi, Lynn E.; Sommer, Iris E.; Cummins, Russel; Shiers, David; Lee, Jimmy; Every-Palmer, Susanna; Mhalla, Ahmed; Chadly, Zohra; Chan, Sherry K.W.; Cotes, Robert O.; Takahashi, Shun; Benros, Michael E.; Wagner, Elias; Correll, Christoph U.; Hasan, Alkomiet; Siskind, Dan; Endres, Dominique; MacCabe, James; Tiihonen, Jari. 2023. The Lancet Psychiatry. 10: 644-652

Association of pharmacological treatments and real‐world outcomes in borderline personality disorder

Lieslehto, Johannes; Tiihonen, Jari; Lähteenvuo, Markku; Mittendorfer‐Rutz, Ellenor; Tanskanen, Antti; Taipale, Heidi. 2023. Acta psychiatrica scandinavica. 147: 603-613

Cause-specific excess mortality after first diagnosis of bipolar disorder: population-based cohort study

Paljärvi, Tapio; Herttua, Kimmo; Taipale, Heidi; Lähteenvuo, Markku; Tanskanen, Antti; Fazel, Seena; Tiihonen, Jari. 2023. BMJ mental health. 26:

Cohort profile: SUPER-Finland – the Finnish study for hereditary mechanisms of psychotic disorders

Lähteenvuo, Markku; Ahola-Olli, Ari; Suokas, Kimmo; Holm, Minna; Misiewicz, Zuzanna; Jukuri, Tuomas; Männynsalo, Teemu; Wegelius, Asko; Haaki, Willehard; Kajanne, Risto; Kyttälä, Aija; Tuulio-Henriksson, Annamari; Lahdensuo, Kaisla; Häkkinen, Katja; Hietala, Jarmo; Paunio, Tiina; Niemi-Pynttäri, Jussi; Kieseppä, Tuula; Veijola, Juha; Lönnqvist, Jouko; Isometsä, Erkki; Kampman, Olli; Tiihonen, Jari; Hyman, Steven; Neale, Benjamin; Daly, Mark; Suvisaari, Jaana; Palotie, Aarno. 2023. BMJ open. 13:

Comparative Effectiveness of Pharmacotherapies for the Risk of Attempted or Completed Suicide Among Persons With Borderline Personality Disorder

Lieslehto, Johannes; Tiihonen, Jari; Lähteenvuo, Markku; Mittendorfer-Rutz, Ellenor; Tanskanen, Antti; Taipale, Heidi. 2023. JAMA network open. 6:

Effects of Substance Use and Antisocial Personality on Neuroimaging-Based Machine Learning Prediction of Schizophrenia

Taipale, Matias; Tiihonen, Jari; Korhonen, Juuso; Popovic, David; Vaurio, Olli; Lähteenvuo, Markku; Lieslehto, Johannes. 2023. Schizophrenia bulletin. [Epub ahead of print: 14 July 2023]: 1-11

Efficacy of immersive extended reality (XR) interventions on different symptom domains of schizophrenia spectrum disorders. A systematic review

Holopainen, Roope; Tiihonen, Jari; Lähteenvuo, Markku. 2023. Frontiers in psychiatry. 14: . 1208287

Functional Characterization of Six SLCO1B1 (OATP1B1) Variants Observed in Finnish Individuals with a Psychotic Disorder

Häkkinen, Katja; Kiander, Wilma; Kidron, Heidi; Lähteenvuo, Markku; Urpa, Lea; Lintunen, Jonne; Vellonen, Kati Sisko; Auriola, Seppo; Holm, Minna; Lahdensuo, Kaisla; Kampman, Olli; Isometsä, Erkki; Kieseppä, Tuula; Lönnqvist, Jouko; Suvisaari, Jaana; Hietala, Jarmo; Tiihonen, Jari; Palotie, Aarno; Ahola-Olli, Ari V.; Niemi, Mikko. 2023. Molecular pharmaceutics. 20: 1500-1508

General and violent recidivism of former forensic psychiatric patients in Finland

Ojansuu, Ilkka; Latvala, Antti; Kautiainen, Hannu; Forsman, Jonas; Tiihonen, Jari; Lähteenvuo, Markku. 2023. Frontiers in psychiatry. 14: . 1157171

Non-adherence to mood stabilizers and antipsychotics among persons with bipolar disorder-A nationwide cohort study

Lintunen, Jonne; Lahteenvuo, Markku; Tanskanen, Antti; Tiihonen, Jari; Taipale, Heidi. 2023. Journal of affective disorders. 333: 403-408

Real-world effectiveness of antidepressant use in persons with schizophrenia: within-individual study of 61,889 subjects

Puranen, Arto; Koponen, Marjaana; Lähteenvuo, Markku; Tanskanen, Antti; Tiihonen, Jari; Taipale, Heidi. 2023. Schizophrenia. 9:

Real-world effectiveness of pharmacological treatments for bipolar disorder: Register-based national cohort study

Lähteenvuo, Markku; Paljärvi, Tapio; Tanskanen, Antti; Taipale, Heidi; Tiihonen, Jari. 2023. British journal of psychiatry. [Published 03 July 2023]: 1-9

Real-world use of pharmacological treatments for incident bipolar disorder: A Finnish nationwide cohort study

Koistinaho, Aura; Poranen, Juulia; Tanskanen, Antti; Tiihonen, Jari; Taipale, Heidi; Lähteenvuo, Markku. 2023. Journal of affective disorders. 340: 237-244

Safety of Antipsychotic Polypharmacy Versus Monotherapy in a Nationwide Cohort of 61,889 Patients With Schizophrenia

Taipale, Heidi; Tanskanen, Antti; Tiihonen, Jari. 2023. American journal of psychiatry. 180: 377-385

Substance Use and Sleep Problems in Patients With Psychotic Disorders

Cederlöf, Erik; Holm, Minna; Ahti, Johan; Lähteenvuo, Markku; Hietala, Jarmo; Häkkinen, Katja; Isometsä, Erkki; Kampman, Olli; Lahdensuo, Kaisla; Lönnqvist, Jouko; Suvisaari, Jaana; Tiihonen, Jari; Wegelius, Asko; Veijola, Juha; Palotie, Aarno; Kieseppä, Tuula; Niemelä, Solja; Paunio, Tiina. 2023. Schizophrenia bulletin open. 4: . sgac073

The use of long-acting injectables in early-phase schizophrenia

Tiihonen, Jari. 2023. The Lancet Psychiatry. 10: 481-482

Use of antipsychotics and antidepressants in first‐episode psychotic depression: A nationwide register‐based study

Hamina, A; Paljärvi, T; Tanskanen, A; Lähteenvuo, M; Tiihonen, J; Taipale, H. 2023. Acta psychiatrica scandinavica. [First published: 06 September 2023]: 1-10

Validation of the Collaborative Outcomes study on Health and Functioning during Infection Times (COH-FIT) questionnaire for adults

Solmi, Marco; Thompson, Trevor; Estradé, Andrés; Agorastos, Agorastos; Radua, Joaquim; Cortese, Samuele; Dragioti, Elena; Leisch, Friedrich; Vancampfort, Davy; Thygesen, Lau Caspar; Aschauer, Harald; Schlögelhofer, Monika; Aschauer, Elena; Schneeberger, Andres; Huber, Christian G.; Hasler, Gregor; Conus, Philippe; Do Cuénod, Kim Q.; von Känel, Roland; Arrondo, Gonzalo; Fusar-Poli, Paolo; Gorwood, Philip; Llorca, Pierre-Michel; Krebs, Marie-Odile; Scanferla, Elisabetta; Kishimoto, Taishiro; Rabba. 2023. Journal of affective disorders. 326: 249-261

β2-Adrenoceptor Agonists in Asthma or Chronic Obstructive Pulmonary Disease and Risk of Parkinson’s Disease: Nested Case-Control Study

Paakinaho, Anne; Tiihonen, Miia; Koskela, Heikki; Koponen, Marjaana; Tiihonen, Jari; Hartikainen, Sirpa; Tolppanen, Anna-Maija. 2023. Clinical epidemiology. 15: 695-705

Aberrant motor contagion of emotions in psychopathy and high-functioning autism

Sun, Lihua; Lukkarinen, Lasse; Noppari, Tuomo; Nazari-Farsani, Sanaz; Putkinen, Vesa; Seppala, Kerttu; Hudson, Matthew; Tani, Pekka; Lindberg, Nina; Karlsson, Henry K.; Hirvonen, Jussi; Salomaa, Marja; Venetjoki, Niina; Lauerma, Hannu; Tiihonen, Jari; Nummenmaa, Lauri. 2022. Cerebral cortex. 2023; 33: 374-384

Allopurinol, dipyridamole and calcium channel blockers in the treatment of bipolar disorder – A nationwide cohort study

Lintunen, Jonne; Lähteenvuo, Markku; Tanskanen, Antti; Tiihonen, Jari; Taipale, Heidi. 2022. Journal of affective disorders. 313: 43-48

Antipsychotic Use and Risk of Low-Energy Fractures in People With Schizophrenia: A Nationwide Nested Case-Control Study in Finland

Solmi, Marco; Lähteenvuo, Markku; Correll, Christoph U; Tanskanen, Antti; Tiihonen, Jari; Taipale, Heidi. 2022. Schizophrenia bulletin. 2023; 49: 78-89

Association of Pharmacological Treatments and Hospitalization and Death in Individuals With Amphetamine Use Disorders in a Swedish Nationwide Cohort of 13 965 Patients

Heikkinen, Milja; Taipale, Heidi; Tanskanen, Antti; Mittendorfer-Rutz, Ellenor; Lähteenvuo, Markku; Tiihonen, Jari. 2022. JAMA psychiatry. 2023; 80: 31-39

Association of Treatment-Resistant Depression With Patient Outcomes and Health Care Resource Utilization in a Population-Wide Study

Lundberg, Johan; Cars, Thomas; Lööv, Sven-Åke; Söderling, Jonas; Sundström, Johan; Tiihonen, Jari; Leval, Amy; Gannedahl, Anna; Björkholm, Carl; Själin, Mikael; Hellner, Clara. 2022. JAMA psychiatry. 2023; 80: 167-175

Associations between antipsychotic use, substance use and relapse risk in patients with schizophrenia: real-world evidence from two national cohorts

Lähteenvuo, Markku; Luykx, Jurjen J.; Taipale, Heidi; Mittendorfer-Rutz, Ellenor; Tanskanen, Antti; Batalla, Albert; Tiihonen, Jari. 2022. British journal of psychiatry. 221: 758-765

Brain structural alterations in autism and criminal psychopathy

Noppari, Tuomo; Sun, Lihua; Lukkarinen, Lasse; Putkinen, Vesa; Tani, Pekka; Lindberg, Nina; Saure, Emma; Lauerma, Hannu; Tiihonen, Jari; Venetjoki, Niina; Salomaa, Marja; Rautio, Päivi; Hirvonen, Jussi; Salmi, Juha; Nummenmaa, Lauri. 2022. Neuroimage : clinical. 35:

Clinical and societal burden of incident major depressive disorder: A population‐wide cohort study in Stockholm

Lundberg, Johan; Cars, Thomas; Lööv, Sven‐Åke; Söderling, Jonas; Tiihonen, Jari; Leval, Amy; Gannedahl, Anna; Björkholm, Carl; Själin, Mikael; Hellner, Clara. 2022. Acta psychiatrica scandinavica. 146: 51-63

Clozapine and the risk of haematological malignancies – Authors' reply

Tiihonen, Jari; Tanskanen, Antti; Bell, J Simon; Dawson, Jessica L; Kataja, Vesa; Taipale, Heidi. 2022. The Lancet Psychiatry. 9: 539-540

Comparative effectiveness of mood stabilizers and antipsychotics in the prevention of hospitalization after lithium discontinuation in bipolar disorder

Holm, M.; Tanskanen, A.; Lähteenvuo, M.; Tiihonen, J.; Taipale, H.. 2022. European neuropsychopharmacology. 61: 36-42

Courses of treatment and risk factors for treatment-resistant depression in Finnish primary and special healthcare: A nationwide cohort study

Lähteenvuo, Markku; Taipale, Heidi; Tanskanen, Antti; Rannanpää, Saara; Tiihonen, Jari. 2022. Journal of affective disorders. 308: 236-242

Differences in psychosocial functioning between psychotic disorders in the Finnish SUPER study

Ahti, Johan; Kieseppä, Tuula; Suvisaari, Jaana; Suokas, Kimmo; Holm, Minna; Wegelius, Asko; Ahola-Olli, Ari; Häkkinen, Katja; Kampman, Olli; Lähteenvuo, Markku; Paunio, Tiina; Tiihonen, Jari; Tuulio-Henriksson, Annamari; Isometsä, Erkki. 2022. Schizophrenia research. 244: 10-17

Effectiveness of Antipsychotic Use for Reducing Risk of Work Disability: Results From a Within-Subject Analysis of a Swedish National Cohort of 21,551 Patients With First-Episode Nonaffective Psychosis

Solmi, Marco; Taipale, Heidi; Holm, Minna; Tanskanen, Antti; Mittendorfer-Rutz, Ellenor; Correll, Christoph U.; Tiihonen, Jari. 2022. American journal of psychiatry. 179: 938-946

Factors and their weight in reducing life expectancy in schizophrenia

Correll, Christoph U.; Bitter, István; Hoti, Fabian; Mehtälä, Juha; Wooller, Annette; Pungor, Katalin; Tiihonen, Jari. 2022. Schizophrenia research. 250: 67-75

Female Psychopathy and Mortality

Vaurio, Olli; Lähteenvuo, Markku; Kautiainen, Hannu; Repo-Tiihonen, Eila; Tiihonen, Jari. 2022. Frontiers in psychiatry. 13: . 831410

Genome-wide association analyses of symptom severity among clozapine-treated patients with schizophrenia spectrum disorders

Okhuijsen-Pfeifer, C.; van der Horst, M. Z.; Bousman, C. A.; Lin, B.; van Eijk, K. R.; Ripke, S.; Ayhan, Y.; Babaoglu, M. O.; Bak, M.; Alink, W.; van Beek, H.; Beld, E.; Bouhuis, A.; Edlinger, M.; Erdogan, I. M.; Ertuğrul, A.; Yoca, G.; Everall, I. P.; Görlitz, T.; van Amelsvoort, T.; Bartels-Velthuis, A. A.; Bruggeman, R.; Cahn, W.; Guloksuz, S.; de Haan, L.; Kahn, R. S.; Schirmbeck, F.; Simons, C. J.P.; van Os, J.; Alizadeh, B. Z.; Luykx, J. J.; Rutten, B. P.F.; van Winkel, R.; Grootens, K. P.. 2022. Translational psychiatry. 12: . 145

Half a century of research on antipsychotics and schizophrenia: A scientometric study of hotspots, nodes, bursts, and trends

Sabe, Michel; Pillinger, Toby; Kaiser, Stefan; Chen, Chaomei; Taipale, Heidi; Tanskanen, Antti; Tiihonen, Jari; Leucht, Stefan; Correll, Christoph U.; Solmi, Marco. 2022. Neuroscience and biobehavioral reviews. 136:

Healthcare utilization, costs, and productivity losses in treatment-resistant depression in Finland – a matched cohort study

Taipale, Heidi; Lähteenvuo, Markku; Tanskanen, Antti; Huoponen, Saara; Rannanpää, Saara; Tiihonen, Jari. 2022. Bmc psychiatry. 22: . 484

Implementation of CYP2D6 copy-number imputation panel and frequency of key pharmacogenetic variants in Finnish individuals with a psychotic disorder

Häkkinen, Katja; Kiiski, Johanna I; Lähteenvuo, Markku; Jukuri, Tuomas; Suokas, Kimmo; Niemi-Pynttäri, Jussi; Kieseppä, Tuula; Männynsalo, Teemu; Wegelius, Asko; Haaki, Willehard; Lahdensuo, Kaisla; Kajanne, Risto; Kaunisto, Mari A; Tuulio-Henriksson, Annamari; Kampman, Olli; Hietala, Jarmo; Veijola, Juha; Lönnqvist, Jouko; Isometsä, Erkki; Paunio, Tiina; Suvisaari, Jaana; Kalso, Eija; Niemi, Mikko; Tiihonen, Jari; Daly, Mark; Palotie, Aarno; Ahola-Olli, Ari V. 2022. Pharmacogenomics journal. 22: 166-172

Long-term treatment with clozapine and other antipsychotic drugs and the risk of haematological malignancies in people with schizophrenia: a nationwide case-control and cohort study in Finland

Tiihonen, Jari; Tanskanen, Antti; Bell, J Simon; Dawson, Jessica L; Kataja, Vesa; Taipale, Heidi. 2022. The Lancet Psychiatry. 9: 353-362

Lääkehoito voi vähentää psyykkisiin sairauksiin liittyvää ennenaikaista kuolleisuutta

Tiihonen, Jari. 2022. Lääkärilehti. 77: 1999

Mortality in people with schizophrenia: a systematic review and meta‐analysis of relative risk and aggravating or attenuating factors

Correll, Christoph U; Solmi, Marco; Croatto, Giovanni; Schneider, Lynne Kolton; Rohani‐Montez, S Christy; Fairley, Leanne; Smith, Nathalie; Bitter, István; Gorwood, Philip; Taipale, Heidi; Tiihonen, Jari. 2022. World psychiatry. 21: 248-271

Mortality in psychotic depression: 18-year follow-up study

Paljärvi, Tapio; Tiihonen, Jari; Lähteenvuo, Markku; Tanskanen, Antti; Fazel, Seena; Taipale, Heidi. 2022. British journal of psychiatry. 2023; 222: 37-43

Mu-opioid receptor system modulates responses to vocal bonding and distress signals in humans

Sun, Lihua; Lukkarinen, Lasse; Putkinen, Vesa; Karlsson, Henry K; Hirvonen, Jussi; Tiihonen, Jari; Lauerma, Hannu; Scott, Sophie; Nummenmaa, Lauri. 2022. Philosophical transactions of the Royal Society B: biological sciences. 377: . 20210181

Optimal Doses of Specific Antipsychotics for Relapse Prevention in a Nationwide Cohort of Patients with Schizophrenia

Taipale, Heidi; Tanskanen, Antti; Luykx, Jurjen J; Solmi, Marco; Leucht, Stefan; Correll, Christoph U; Tiihonen, Jari. 2022. Schizophrenia bulletin. 48: 774-784

Physical and mental health impact of COVID-19 on children, adolescents, and their families: The Collaborative Outcomes study on Health and Functioning during Infection Times - Children and Adolescents (COH-FIT-C&A)

Solmi, Marco; Estradé, Andrés; Thompson, Trevor; Agorastos, Agorastos; Radua, Joaquim; Cortese, Samuele; Dragioti, Elena; Leisch, Friedrich; Vancampfort, Davy; Thygesen, Lau Caspar; Aschauer, Harald; Schloegelhofer, Monika; Akimova, Elena; Schneeberger, Andres; Huber, Christian G.; Hasler, Gregor; Conus, Philippe; Cuénod, Kim Q. Do; von Känel, Roland; Arrondo, Gonzalo; Fusar-Poli, Paolo; Gorwood, Philip; Llorca, Pierre-Michel; Krebs, Marie-Odile; Scanferla, Elisabetta; Kishimoto, Taishiro; Rabba. 2022. Journal of affective disorders. 299: 367-376

Primary Nonadherence to Antipsychotic Treatment Among Persons with Schizophrenia

Lieslehto, Johannes; Tiihonen, Jari; Lähteenvuo, Markku; Tanskanen, Antti; Taipale, Heidi. 2022. Schizophrenia bulletin. 48: 655-663

Prolaktiinipitoisuutta suurentavat psykoosilääkkeet ja rintasyöpäriski rekisteritiedon valossa

Tiihonen, Jari; Kataja, Vesa; Lähteenvuo, Markku; Taipale, Heidi . 2022. Duodecim. 138: 296-298

Psychosis and the Risk of Stranger Homicides

Ojansuu, Ilkka; Lähteenvuo, Markku; Tiihonen, Jari; Lehti, Martti; Putkonen, Hanna. 2022. Schizophrenia bulletin open. 3: . sgac021

Psychotic depression and deaths due to suicide

Paljärvi, Tapio; Tiihonen, Jari; Lähteenvuo, Markku; Tanskanen, Antti; Fazel, Seena; Taipale, Heidi. 2022. Journal of affective disorders. 2023; 321: 28-32

Real-world effectiveness of antipsychotic doses for relapse prevention in patients with first-episode schizophrenia in Finland: a nationwide, register-based cohort study

Taipale, Heidi; Tanskanen, Antti; Correll, Christoph U; Tiihonen, Jari. 2022. The Lancet Psychiatry. 9: 271-279

Real-world effectiveness studies of low doses of antipsychotics – Authors' reply

Taipale, Heidi; Tanskanen, Antti; Correll, Christoph U; Tiihonen, Jari. 2022. The Lancet Psychiatry. 9: 536-537

Real‐world effectiveness of mood stabilizer use in schizophrenia

Puranen, Arto; Koponen, Marjaana; Lähteenvuo, Markku; Tanskanen, Antti; Tiihonen, Jari; Taipale, Heidi. 2022. Acta psychiatrica scandinavica. 2023; 147: 257-266

Real‐world effectiveness of pharmacological treatments of opioid use disorder in a national cohort

Heikkinen, Milja; Taipale, Heidi; Tanskanen, Antti; Mittendorfer‐Rutz, Ellenor; Lähteenvuo, Markku; Tiihonen, Jari. 2022. Addiction. 117: 1683-1691

Representation and Outcomes of Individuals With Schizophrenia Seen in Everyday Practice Who Are Ineligible for Randomized Clinical Trials

Taipale, Heidi; Schneider-Thoma, Johannes; Pinzón-Espinosa, Justo; Radua, Joaquim; Efthimiou, Orestis; Vinkers, Christiaan H; Mittendorfer-Rutz, Ellenor; Cardoner, Narcís; Pintor, Luis; Tanskanen, Antti; Tomlinson, Anneka; Fusar-Poli, Paolo; Cipriani, Andrea; Vieta, Eduard; Leucht, Stefan; Tiihonen, Jari; Luykx, Jurjen J. 2022. JAMA psychiatry. 79: 210-218

Sleep in Psychotic Disorders: Results From Nationwide SUPER Finland Study

Cederlöf, Erik; Holm, Minna; Lähteenvuo, Markku; Haaki, Willehard; Hietala, Jarmo; Häkkinen, Katja; Isometsä, Erkki; Jukuri, Tuomas; Kajanne, Risto; Kampman, Olli; Kieseppä, Tuula; Lahdensuo, Kaisla; Lönnqvist, Jouko; Männynsalo, Teemu; Niemi-Pynttäri, Jussi; Suokas, Kimmo; Suvisaari, Jaana; Tiihonen, Jari; Turunen, Hannu; Wegelius, Asko; Veijola, Juha; Palotie, Aarno; Paunio, Tiina. 2022. Schizophrenia bulletin open. 3:

The collaborative outcomes study on health and functioning during infection times in adults (COH-FIT-Adults): Design and methods of an international online survey targeting physical and mental health effects of the COVID-19 pandemic

Solmi, Marco; Estradé, Andrés; Thompson, Trevor; Agorastos, Agorastos; Radua, Joaquim; Cortese, Samuele; Dragioti, Elena; Leisch, Friedrich; Vancampfort, Davy; Thygesen, Lau Caspar; Aschauer, Harald; Schloegelhofer, Monika; Akimova, Elena; Schneeberger, Andres; Huber, Christian G.; Hasler, Gregor; Conus, Philippe; Cuénod, Kim Q. Do; von Känel, Roland; Arrondo, Gonzalo; Fusar-Poli, Paolo; Gorwood, Philip; Llorca, Pierre-Michel; Krebs, Marie-Odile; Scanferla, Elisabetta; Kishimoto, Taishiro; Rabba. 2022. Journal of affective disorders. 299: 393-407

Twenty-year medication use trends in first-episode bipolar disorder

Poranen, Juulia; Koistinaho, Aura; Tanskanen, Antti; Tiihonen, Jari; Taipale, Heidi; Lähteenvuo, Markku. 2022. Acta psychiatrica scandinavica. 146: 583-593

Vuoden 2022 Matti Äyräpään palkinnon saaja Jari Tiihonen: Lääkehoitojen vaikuttavuustutkimus vie kohti dataohjautuvaa terveydenhuoltoa

Tiihonen, Jari. 2022. Duodecim. 138: 2091-2092

Women with Schizophrenia-Spectrum Disorders After Menopause: A Vulnerable Group for Relapse

Sommer, Iris E; Brand, Bodyl A; Gangadin, Shiral; Tanskanen, Antti; Tiihonen, Jari; Taipale, Heidi. 2022. Schizophrenia bulletin. 2023; 49: 136-143

Adenosine modulators and calcium channel blockers as add-on treatment for schizophrenia

Lintunen, Jonne; Lähteenvuo, Markku; Tiihonen, Jari; Tanskanen, Antti; Taipale, Heidi. 2021. NPJ schizophrenia. 7: 1

Antipsychotic Polypharmacy for the Management of Schizophrenia: Evidence and Recommendations

Lähteenvuo, Markku; Tiihonen, Jari. 2021. Drugs. 81: 1273-1284

Antipsychotic discontinuation: mind the patient and the real-world evidence

Luykx, Jurjen J; Tiihonen, Jari. 2021. The Lancet Psychiatry. 8: 555-557

Antipsychotic use and risk of breast cancer in women with schizophrenia: a nationwide nested case-control study in Finland

Taipale, Heidi; Solmi, Marco; Lähteenvuo, Markku; Tanskanen, Antti; Correll, Christoph U; Tiihonen, Jari. 2021. The Lancet Psychiatry. 8: 883-891

Antipsychotics Use Is Associated With Greater Adherence to Cardiometabolic Medications in Patients With Schizophrenia: Results From a Nationwide, Within-subject Design Study

Solmi, Marco; Tiihonen, Jari; Lähteenvuo, Markku; Tanskanen, Antti; Correll, Christoph U; Taipale, Heidi. 2021. Schizophrenia bulletin. 2022; 48: 166-175

Associations of age, sex, sexual abuse, and genotype with monoamine oxidase a gene methylation

Checknita, David; Tiihonen, Jari; Hodgins, Sheilagh; Nilsson, Kent W. 2021. Journal of neural transmission. 128: 1721-1739

Brain Basis of Psychopathy in Criminal Offenders and General Population

Nummenmaa, Lauri; Lukkarinen, Lasse; Sun, Lihua; Putkinen, Vesa; Seppälä, Kerttu; Karjalainen, Tomi; Karlsson, Henry K; Hudson, Matthew; Venetjoki, Niina; Salomaa, Marja; Rautio, Päivi; Hirvonen, Jussi; Lauerma, Hannu; Tiihonen, Jari. 2021. Cerebral cortex. 31: 4104-4114

Changes in the metabolic profile of human male postmortem frontal cortex and cerebrospinal fluid samples associated with heavy alcohol use

Kärkkäinen, Olli; Kokla, Marietta; Lehtonen, Marko; Auriola, Seppo; Martiskainen, Mika; Tiihonen, Jari; Karhunen, Pekka J.; Hanhineva, Kati; Kok, Eloise. 2021. Addiction biology. 26: e13035

Clozapine, Long-Acting Injectables (and Polypharmacy?) Superior in U.S. and International Registries

Leucht, Stefan; Tiihonen, Jari. 2021. American journal of psychiatry. 178: 888 - 889

Continuity of antipsychotic medication use among migrant and Finnish-born populations with a psychotic disorder: a register-based study

Lehti, Venla; Taipale, Heidi; Gissler, Mika; Tanskanen, Antti; Elonheimo, Martta; Tiihonen, Jari; Suvisaari, Jaana. 2021. Psychological medicine. [online 02 June 2021]: 1-11

Contribution of astrocytes to familial risk and clinical manifestation of schizophrenia

Koskuvi, Marja; Lehtonen, ¦árka; Trontti, Kalevi; Keuters, Meike; Wu, Ying-Chieh; Koivisto, Hennariikka; Ludwig, Anastasia; Plotnikova, Lidiia; Virtanen, Pekka LJ; Räsänen, Noora; Kaipainen, Satu; Hyötyläinen, Ida; Dhungana, Hiramani; Giniatullina, Raisa; Ojansuu, Ilkka; Vaurio, Olli; Cannon, Tyrone D; Lönnqvist, Jouko; Therman, Sebastian; Suvisaari, Jaana; Kaprio, Jaakko; Lähteenvuo, Markku; Tohka, Jussi; Giniatullin, Rashid; Rivera, Claudio; Hovatta, Iiris; Tanila, Heikki; Tiihonen, Jari; Koi. 2021. Glia. 2022; 70: 650-660

Correspondence regarding De Girolamo et al., 2021 'A multinational case-control study comparing forensic and non-forensic patients with schizophrenia spectrum disorders: the EU-VIORMED project'

Hodgins, Sheilagh; Eronen, Markku; Freese, Roland; Hart, Stephen; Mueller-Isberner, Ruediger; Ross, Deborah; Webster, Christopher; Tiihonen, Jari. 2021. Psychological medicine. Published online: 02 November 2021: 1 - 2

Effectiveness of pharmacotherapies for delusional disorder in a Swedish national cohort of 9076 patients

Lähteenvuo, Markku; Taipale, Heidi; Tanskanen, Antti; Mittendorfer-Rutz, Ellenor; Tiihonen, Jari. 2021. Schizophrenia research. 228: 367-372

Exploring the relation between high-activity COMT Val158Met genotype and psychopathy in male offenders

Pauli, Malin; Ölund Alonso, Hannibal; Liljeberg, Jenny; Gustavsson, Petter; Tiihonen, Jari; Howner, Katarina. 2021. Journal of forensic psychiatry and psychology. 2022; 33: 172-177

HLA-DQB1 6672G>C (rs113332494) is associated with clozapine-induced neutropenia and agranulocytosis in individuals of European ancestry

Konte, Bettina; Walters, James TR; Rujescu, Dan; Legge, Sophie E; Pardiñas, Antonio F; Cohen, Dan; Pirmohamed, Munir; Tiihonen, Jari; Hartmann, Annette M; Bogers, Jan P; van der Weide, Jan; van der Weide, Karen; Putkonen, Anu; Repo-Tiihonen, Eila; Hallikainen, Tero; Silva, Ed; Ingimarsson, Oddur; Sigurdsson, Engilbert; Kennedy, James L; Sullivan, Patrick F et al.. 2021. Translational psychiatry. 11: 214

Hip Fracture Risk in Antiepileptic Drug Initiators and Non-Initiators with Alzheimer's Disease

Pisa, Federica; Reinold, Jonas; Lavikainen, Piia; Koponen, Marjaana; Taipale, Heidi; Tanskanen, Antti; Tiihonen, Jari; Hartikainen, Sirpa; Tolppanen, Anna-Maija. 2021. Clinical epidemiology. 13: 295-307

Incidence of schizophrenia and influence of prenatal and infant exposure to viral infectious diseases

Tanskanen, Antti; Taipale, Heidi; Cannon, Mary; Cotter, David; Tiihonen, Jari. 2021. Acta psychiatrica scandinavica. 143: 487-494

Long-Term Real-World Effectiveness of Pharmacotherapies for Schizoaffective Disorder

Lintunen, Jonne; Taipale, Heidi; Tanskanen, Antti; Mittendorfer-Rutz, Ellenor; Tiihonen, Jari; Lähteenvuo, Markku. 2021. Schizophrenia bulletin. 47: 1099-1107

Long-term Continuity of Antipsychotic Treatment for Schizophrenia: A Nationwide Study

Rubio, Jose M; Taipale, Heidi; Tanskanen, Antti; Correll, Christoph U; Kane, John M; Tiihonen, Jari. 2021. Schizophrenia bulletin. 47: 1611-1620

Reaction Time and Visual Memory in Connection to Alcohol Use in Persons with Bipolar Disorder

Mazumder, Atiqul Haq; Barnett, Jennifer; Isometsä, Erkki Tapio; Lindberg, Nina; Torniainen-Holm, Minna; Lähteenvuo, Markku; Lahdensuo, Kaisla; Kerkelä, Martta; Ahola-Olli, Ari; Hietala, Jarmo; Kampman, Olli; Kieseppä, Tuula; Jukuri, Tuomas; Häkkinen, Katja; Cederlöf, Erik; Haaki, Willehard; Kajanne, Risto; Wegelius, Asko; Männynsalo, Teemu; Niemi-Pynttäri, Jussi [incl. Tiihonen, Jari]. 2021. Brain sciences. 11: 1154

Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder

Mazumder, Atiqul Haq; Barnett, Jennifer; Isometsä, Erkki Tapio; Lindberg, Nina; Torniainen-Holm, Minna; Lähteenvuo, Markku; Lahdensuo, Kaisla; Kerkelä, Martta; Ahola-Olli, Ari; Hietala, Jarmo; Kampman, Olli; Kieseppä, Tuula; Jukuri, Tuomas; Häkkinen, Katja; Cederlöf, Erik; Haaki, Willehard; Kajanne, Risto; Wegelius, Asko; Männynsalo, Teemu; Niemi-Pynttäri, Jussi; Suokas, Kimmo; Lönnqvist, Jouko; Tiihonen, Jari; Paunio, Tiina; Vainio, Seppo Juhani; Palotie, Aarno; Niemelä, Solja; Suvisaari, Jaana. 2021. Brain sciences. 11: 1422

Reaction Time and Visual Memory in Connection with Alcohol Use in Schizophrenia and Schizoaffective Disorder

Mazumder, Atiqul Haq; Barnett, Jennifer; Lindberg, Nina; Torniainen-Holm, Minna; Lähteenvuo, Markku; Lahdensuo, Kaisla; Kerkelä, Martta; Hietala, Jarmo; Isometsä, Erkki Tapio; Kampman, Olli; Kieseppä, Tuula; Jukuri, Tuomas; Häkkinen, Katja; Cederlöf, Erik; Haaki, Willehard; Kajanne, Risto; Wegelius, Asko; Männynsalo, Teemu; Niemi-Pynttäri, Jussi; Suokas, Kimmo; et al [incl. Tiihonen, Jari]. 2021. Brain sciences. 11: 688

Real-world effectiveness of pharmacological treatments of alcohol use disorders in a Swedish nation-wide cohort of 125-556 patients

Heikkinen, Milja; Taipale, Heidi; Tanskanen, Antti; Mittendorfer-Rutz, Ellenor; Lähteenvuo, Markku; Tiihonen, Jari. 2021. Addiction. 116: 1990-1998

Registry-based studies: What they can tell us, and what they cannot

Taipale, Heidi; Tiihonen, Jari. 2021. European neuropsychopharmacology. 45: 35-37

Risk Factors, Incidence, and Outcomes of Neuroleptic Malignant Syndrome on Long-Acting Injectable vs Oral Antipsychotics in a Nationwide Schizophrenia Cohort

Guinart, Daniel; Taipale, Heidi; Rubio, Jose M; Tanskanen, Antti; Correll, Christoph U; Tiihonen, Jari; Kane, John M. 2021. Schizophrenia bulletin. 47: 1621-1630

Risk of labour market marginalisation among young refugees and non-refugee migrants with common mental disorders

Di Thiene, D; Helgesson, Magnus; Rahman, S; Alexanderson, K; Tiihonen, J; La Torre, G; Mittendorfer-Rutz, E. 2021. Social psychiatry and psychiatric epidemiology. 56: 1024-1034

Switches and early discontinuations of antidepressant medication in young adults with depression

Lampela, Pasi; Tanskanen, Antti; Lähteenvuo, Markku; Tiihonen, Jari; Taipale, Heidi. 2021. Journal of affective disorders. 295: 1474-1481

The iPSC perspective on schizophrenia

Räsänen, Noora; Tiihonen, Jari; Koskuvi, Marja; Lehtonen, ¦árka; Koistinaho, Jari. 2021. Trends in neurosciences. 2022; 41: 8-26

Vaarallisuden ja väkivaltariskin arvioiminen

Tolvanen, Matti; Keski-Valkama, Alice; Koskela, Tarja; Pajuoja, Jussi; Rautanen, Mika; Tiihonen, Jari; Tyni, Sasu; Törölä, Miisa; Eskelinen, Emilia. 2021. Valtioneuvoston selvitys- ja tutkimustoiminnan julkaisusarja. .

Vaarallisuuden ja väkivaltariskin arvioiminen

Tolvanen, Matti; Keski-Valkama, Alice; Koskela, Tarja; Pajuoja, Jussi; Rautanen, Mika; Tiihonen, Jari; Tyni, Sasu; Törölä, Miisa; Eskelinen, Emilia. 2021. Valtioneuvoston selvitys- ja tutkimustoiminnan julkaisusarja. .

Voluntary patient safety incidents reporting in forensic psychiatry - What do the reports tell us?

Kuosmanen, Anssi; Tiihonen, Jari; Repo-Tiihonen, Eila; Turunen, Hannele. 2021. Journal of psychiatric and mental health nursing. 2022; 29: 36-47

20-year follow-up study of physical morbidity and mortality in relationship to antipsychotic treatment in a nationwide cohort of 62,250 patients with schizophrenia (FIN20)

Taipale, H; Tanskanen, A; Mehtälä, J; Vattulainen, P; Correll, CU; Tiihonen, J. 2020. World psychiatry. 19: 61-68

A Systematic Literature Review of Neuroimaging of Psychopathic Traits

Johanson, Mika; Vaurio, Olli; Tiihonen, Jari; Lähteenvuo, Markku. 2020. Frontiers in psychiatry. 10: 1027

Antiepileptic drug use and mortality among community-dwelling persons with Alzheimer disease

Sarycheva, Tatyana; Lavikainen, Piia; Taipale, Heidi; Tiihonen, Jari; Tanskanen, Antti; Hartikainen, Sirpa; Tolppanen, Anna-Maija. 2020. Neurology. 94: e2099-e2108

Antipsychotic use among persons with schizophrenia in Sweden and Finland, trends and differences

Taipale, Heidi; Puranen, Arto; Mittendorfer-Rutz, Ellenor; Tiihonen, Jari; Tanskanen, Antti; Cervenka, Simon; Lähteenvuo, Markku. 2020. Nordic journal of psychiatry. 2021; 75: 315-322

Asthma and Chronic Obstructive Pulmonary Disease as a Comorbidity and Association with the Choice of Antidementia Medication Among Persons with Alzheimer's Disease

Lampela, P; Tolppanen, AM; Koponen, M; Tanskanen, A; Tiihonen, J; Hartikainen, S; Taipale, H. 2020. Journal of Alzheimer's disease. 73: 1243-1251

Causes of death in a nationwide cohort of community-dwellers with Alzheimer's disease

Tolppanen, Anna-Maija; Taipale, Heidi; Koponen, Marjaana; Tiihonen, Jari; Hartikainen, Sirpa. 2020. Bmc geriatrics. 20: 441

Commentary on Robert Whitaker's viewpoint

Tiihonen, Jari; Taipale, Heidi; Correll, Christoph U. 2020. Psychological medicine. 50: 2653-2654

Comparative Effectiveness of Antipsychotics for Risk of Attempted or Completed Suicide Among Persons With Schizophrenia

Taipale, Heidi; Lähteenvuo, Markku; Tanskanen, Antti; Mittendorfer-Rutz, Ellenor; Tiihonen, Jari. 2020. Schizophrenia bulletin. 2021; 47: 23-30

Concordance and discordance in how patients and therapists experience the psychotherapy process in the treatment of depression

Ahola, Pasi; Härkänen, Tommi; Lehtonen, Johannes; Lindfors, Olavi; Knekt, Paul; Joensuu, Mikko; Saarinen, Pirjo; Tolmunen, Tommi; Virtala, Esa; Tiihonen, Jari; Valkonen-Korhonen, Minna. 2020. Psychiatria Fennica. 51: 122-141

Detection of medications associated with Alzheimer's disease using ensemble methods and cooperative game theory

Braithwaite, B; Paananen, J; Taipale, H; Tanskanen, A; Tiihonen, J; Hartikainen, S; Tolppanen, A-M. 2020. International journal of medical informatics. 141: 104142

Employment among people with schizophrenia or bipolar disorder: a population-based study using nationwide registers

Holm, Minna; Taipale, Heidi; Tanskanen, Antti; Tiihonen, Jari; Mitterdorfer-Rutz, Ellenor. 2020. Acta psychiatrica scandinavica. 2021; 143: 61-71

Health and Work Disability Outcomes in Parents of Patients With Schizophrenia Associated With Antipsychotic Exposure by the Offspring

Taipale, H; Rahman, S; Tanskanen, A; Mehtälä, J; Hoti, F; Jedenius, E; Enkusson, D; Leval, A; Sermon, J; Tiihonen, J; Mittendorfer-Rutz, E. 2020. Scientific reports. 10: 1219

In the aftermath of clozapine discontinuation: comparative effectiveness and safety of antipsychotics in patients with schizophrenia who discontinue clozapine

Luykx, JJ; Stam, N; Tanskanen, A; Tiihonen, J; Taipale, H. 2020. British journal of psychiatry. 217: 498-505

Incidence of and Characteristics Associated With Long-term Benzodiazepine Use in Finland

Taipale, Heidi; Särkilä, Hanna; Tanskanen, Antti; Kurko, Terhi; Taiminen, Tero; Tiihonen, Jari; Sund, Reijo; Tuulio-Henriksson, Annamari; Saastamoinen, Leena; Hietala, Jarmo. 2020. JAMA network open. 3: e2019029

Length of hospital stay for hip fracture and 30-day mortality in people with Alzheimer's disease: a cohort study in Finland

Lavikainen, Piia; Koponen, Marjaana; Taipale, Heidi; Tanskanen, Antti; Tiihonen, Jari; Hartikainen, Sirpa; Tolppanen, Anna-Maija. 2020. Journals of gerontology series a: biological sciences and medical sciences. 75: 2184-2192

Medication Use and Health Care Utilization After a Cost-sharing Increase in Schizophrenia: A Nationwide Analysis

Hamina, Aleksi; Tanskanen, Antti; Tiihonen, Jari; Taipale, Heidi. 2020. Medical care. 58: 763-769

Medication management of antipsychotic treatment in schizophrenia-A narrative review

Isohanni, Matti; Jääskeläinen, Erika; Miller, Brian J; Hulkko, Anja; Tiihonen, Jari; Möller, Hans-Jurgen; Hartikainen, Sirpa; Huhtaniska, Sanna; Lieslehto, Johannes. 2020. Human psychopharmacology: clinical and experimental. 2021; 36: e2765

Metformin and risk of Alzheimer's disease among community-dwelling people with diabetes: a national case-control study

Sluggett, JK; Koponen, M; Bell, JS; Taipale, H; Tanskanen, A; Tiihonen, J; Uusitupa, M; Tolppanen, AM; Hartikainen, S. 2020. Journal of clinical endocrinology and metabolism. 105: dgz234

Monoamine oxidase A genotype and methylation moderate the association of maltreatment and aggressive behaviour

Checknita, D; Bendre, M; Ekström, TJ; Comasco, E; Tiihonen, J; Hodgins, S; Nilsson, KW. 2020. Behavioural brain research. 382: 112476

Persistence of Antipsychotic Use After Clozapine Discontinuation: A Real-World Study Across Antipsychotics

Stam, Noraly; Taipale, Heidi; Tanskanen, Antti; Isphording, Luka; Okhuijsen-Pfeifer, Cynthia; Schuiling-Veninga, Catharina; Bos, Jens H; Bijker, Bert; Tiihonen, Jari; Luykx, Jurjen. 2020. Cts: clinical and translational science. 13: 1170-1177

Prevalence of cardiovascular drug use before and after diagnosis of Alzheimer's disease

Vu, Mai; Koponen, Marjaana; Taipale, Heidi; Tanskanen, Antti; Tiihonen, Jari; Kettunen, Raimo; Hartikainen, Sirpa; Tolppanen, Anna-Maija. 2020. International journal of cardiology. 300: 221-225

Psychosis relapse during treatment with long-acting injectable antipsychotics in individuals with schizophrenia-spectrum disorders: an individual participant data meta-analysis

Rubio, Jose M; Schoretsanitis, Georgios; John, Majnu; Tiihonen, Jari; Taipale, Heidi; Guinart, Daniel; Malhotra, Anil K; Correll, Christoph U; Kane, John M. 2020. The Lancet Psychiatry. 7: 749-761

Psykoosilääkkeiden käyttö on pitkäkestoista Alzheimerin tautia sairastavilla

Liehu, Maija; Tiihonen, Miia; Taipale, Heidi; Tanskanen, Antti; Tiihonen, Jari; Tolppanen, Anna-Maija; Hartikainen, Sirpa; Koponen, Marjaana. 2020. Dosis. 36: 6-23

Psyykenlääkkeet ja sydän

Kettunen, Raimo; Suvisaari, Jaana; Tiihonen, Jari; Ruskoaho, Heikki; Huikuri, Heikki. 2020. Duodecim. 136: 1411-1418

Rejoinder to rejoinder to commentary

Tiihonen, Jari; Taipale, Heidi; Correll, Christoph U.. 2020. Psychological medicine. 50: 2812-2813

Risk and risk factors for disability pension among patients with treatment resistant depression- a matched cohort study

Taipale, Heidi; Reutfors, Johan; Tanskanen, Antti; Brandt, Lena; Tiihonen, Jari; DiBernardo, Allitia; Mittendorfer-Rutz, Ellenor; Brenner, Philip. 2020. Bmc psychiatry. 20: 232

Suicide mortality and use of psychotropic drugs in patients hospitalized due to bipolar disorder: A Finnish nationwide cohort study

Antolín-Concha, Diego; Lähteenvuo, Markku; Vattulainen, Pia; Tanskanen, Antti; Taipale, Heidi; Vieta, Eduard; Tiihonen, Jari. 2020. Journal of affective disorders. 277: 885-892

The Risk of Head Injuries Associated With Antipsychotic Use Among Persons With Alzheimer's disease

Tapiainen, V; Lavikainen, P; Koponen, M; Taipale, H; Tanskanen, A; Tiihonen, J; Hartikainen, S; Tolppanen, AM. 2020. Journal of the american geriatrics society. 68: 595-602

The clinical course of schizophrenia in women and men-a nation-wide cohort study

Sommer, Iris E; Tiihonen, Jari; van Mourik, Anouk; Tanskanen, Antti; Taipale, Heidi. 2020. NPJ schizophrenia. 6: 12

Use of antidepressants and mood stabilizers in persons with first-episode schizophrenia

Puranen, Arto; Koponen, Marjaana; Tanskanen, Antti; Tiihonen, Jari; Taipale, Heidi. 2020. European journal of clinical pharmacology. 76: 711-718

Vaarallisuuden arviointi - sattuman summaako?

Ahlgrén-Rimpiläinen, Aulikki; Joelsson, Petteri; Kaarre, Hanna; Rautanen, Mika; Niinistö, Kirsi; Lindberg, Nina; Tiihonen, Jari. 2020. Edilex. : 1-30

Valproate and Neuroleptic Malignant Syndrome in an Elderly Patient With Schizoaffective Disorder

Lindeman, Sari; Kolari, Tuukka; Tiihonen, Jari. 2020. The primary care companion for cns disorders. 22: 19l02542

Accumulation of Hospital Days Among Antipsychotic Initiators With Alzheimer's Disease

Koponen, Marjaana; Lavikainen, Piia; Taipale, Heidi; Tanskanen, Antti; Tiihonen, Jari; Hartikainen, Sirpa; Tolppanen, Anna-Maija. 2019. Journal of the american medical directors association. 20: 1488-1494.e3

Adherence to psychotropic medication in completed suicide in Sweden 2006-2013: a forensic-toxicological matched case-control study

Forsman, J; Taipale, H; Masterman, T; Tiihonen, J; Tanskanen, A. 2019. European journal of clinical pharmacology. 75: 1421-1430

Alzheimer-potilaat ja psyykenlääkkeiden käyttö 2005-2011

Juhola, Laura; Taipale, Heidi; Koponen, Marjaana; Tanskanen, Antti; Tiihonen, Jari; Hartikainen, Sirpa; Tolppanen, Anna-Maija. 2019. Lääkärilehti. 74: 609-616

Antiepileptic Drug Use Is Associated with an Increased Risk of Pneumonia Among Community-Dwelling Persons with Alzheimer's Disease-Matched Cohort Study

Taipale, H; Lampela, P; Koponen, M; Tanskanen, A; Tiihonen, J; Hartikainen, S; Tolppanen, AM. 2019. Journal of Alzheimer's disease. 68: 127-136

Antiepileptic Drugs and Accumulation of Hospital Days Among Persons With Alzheimer's Disease

Lavikainen, Piia; Taipale, Heidi; Tanskanen, Antti; Koponen, Marjaana; Tiihonen, Jari; Hartikainen, Sirpa; Tolppanen, Anna-Maija. 2019. Journal of the american medical directors association. 20: 751-758

Association of Antipsychotic Polypharmacy vs Monotherapy With Psychiatric Rehospitalization Among Adults With Schizophrenia

Tiihonen, J; Taipale, H; Mehtälä, J; Vattulainen, P; Correll, CU; Tanskanen, A. 2019. JAMA psychiatry. 76: 499-507

Changes in Patient Safety Culture: A Patient Safety Intervention for Finnish Forensic Psychiatric Hospital Staff

Kuosmanen, A; Tiihonen, J; Repo-Tiihonen, E; Eronen, M; Turunen, H. 2019. Journal of nursing management. 27: 848-857

Hospital-Treated Pneumonia Associated with Opioid Use Among Community Dwellers with Alzheimer's Disease

Hamina, A; Taipale, H; Karttunen, N; Tanskanen, A; Tiihonen, J; Tolppanen, AM; Hartikainen, S. 2019. Journal of Alzheimer's disease. 69: 807-816

Incidence of head injury and traumatic brain injury among people with Alzheimer's disease

Ilmaniemi, S; Taipale, H; Tanskanen, A; Tiihonen, J; Hartikainen, S; Tolppanen, AM. 2019. Journal of epidemiology and community health. 73: 451-454

Increased [³H]quisqualic acid binding density in the dorsal striatum and anterior insula of alcoholics: A post-mortem whole-hemisphere autoradiography study

Laukkanen, V; Kärkkäinen, O; Kautiainen, H; Tiihonen, J; Storvik, M. 2019. Psychiatry research: neuroimaging. 287: 63-69

Long-acting injectable antipsychotics (LAIs) for maintenance treatment of bipolar and schizoaffective disorders: A systematic review

Pacchiarotti, I; Tiihonen, J; Kotzalidis, GD; Verdolini, N; Murru, A; Goikolea, JM; Valentí, M; Aedo, A; Vieta, E. 2019. European neuropsychopharmacology. 29: 457-470

Long-term thiazide use and risk of low-energy fractures among persons with Alzheimer's disease-nested case-control study

Taipale, H; Rysä, J; Hukkanen, J; Koponen, M; Tanskanen, A; Tiihonen, J; Kröger, H; Hartikainen, S; Tolppanen, AM. 2019. Osteoporosis international. 30: 1481-1489

Manifesto for an international digital mental health network

Maron, Eduard; Baldwin, David S; Balõt¨ev, Roman; Fabbri, Chiara; Gaur, Vikas; Hidalgo-Mazzei, Diego; Hood, Sean; Juhola, Martti; Kampman, Olli; Kasper, Siegfried; Kärkkäinen, Hilkka; Látalová, Klára; Lähteenvuo, Markku; Mastellos, Nikolas; McTigue, Joseph; Metsallik, Janek; Metspalu, Andres; Nutt, David; Nykänen, Pirkko; Olisa, Nigel et al. (incl. Tiihonen, Jari). 2019. Digital psychiatry. 2: 14-24

Neurobiological roots of psychopathy

Tiihonen, J; Koskuvi, M; Lähteenvuo, M; Virtanen, PLJ; Ojansuu, I; Vaurio, O; Gao, Y; Hyötyläinen, I; Puttonen, KA; Repo-Tiihonen, E; Paunio, T; Rautiainen, MR; Tyni, S; Koistinaho, J; Lehtonen, S. 2019. Molecular psychiatry. [Epub ahead of print 27 Aug 2019]: 1-10

Opioid Use After Hospital Care due to Hip Fracture Among Community-Dwelling Persons With and Without Alzheimer's Disease

Lintula, E; Tiihonen, M; Taipale, H; Tolppanen, AM; Tanskanen, A; Tiihonen, J; Hartikainen, S; Hamina, A. 2019. Drugs and aging. 2020; 37: 193-203

Predictors of high hospital care and medication costs and cost trajectories in community-dwellers with Alzheimer's disease

Kalamägi, J; Lavikainen, P; Taipale, H; Tanskanen, A; Tiihonen, J; Hartikainen, S; Tolppanen, AM. 2019. Annals of medicine. 51: 294-305

Psychosis breakthrough on antipsychotic maintenance: results from a nationwide study

Rubio, JM; Taipale, H; Correll, CU; Tanskanen, A; Kane, JM; Tiihonen, J. 2019. Psychological medicine. [Epub ahead of print 13 June 2019]: 1-12

Sex-specific transcriptional and proteomic signatures in schizophrenia

Tiihonen, J; Koskuvi, M; Storvik, M; Hyötyläinen, I; Gao, Y; Puttonen, KA; Giniatullina, R; Poguzhelskaya, E; Ojansuu, I; Vaurio, O; Cannon, TD; Lönnqvist, J; Therman, S; Suvisaari, J; Kaprio, J; Cheng, L; Hill, AF; Lähteenvuo, M; Tohka, J; Giniatullin, R; et al.. 2019. Nature communications. 10: 3933

Skitsofrenian lääkehoito

Tiihonen, Jari. 2019. Duodecim. 135: 2021-2027

Substance Abuse and Excessive Mortality Among Forensic Psychiatric Patients: A Finnish Nationwide Cohort Study

Ojansuu, Ilkka; Putkonen, Hanna; Lähteenvuo, Markku; Tiihonen, Jari. 2019. Frontiers in psychiatry. 10: 678

Trajectories of sickness absence, disability pension and unemployment in young immigrants with common mental disorders

Di Thiene, D; Mittendorfer-Rutz, E; Rahman, S; Wang, M; Alexanderson, K; Tiihonen, J; La Torre, G; Helgesson, M. 2019. European journal of public health. 29: 1055-1062

20-Year Nationwide Follow-Up Study on Discontinuation of Antipsychotic Treatment in First-Episode Schizophrenia

Tiihonen, Jari; Tanskanen, Antti; Taipale, Heidi. 2018. American journal of psychiatry. 175: 765-7731-9

Amygdala-orbitofrontal structural and functional connectivity in females with anxiety disorders, with and without a history of conduct disorder

Lindner, P; Flodin, P; Larm, P; Budhiraja, M; Savic-Berglund, I; Jokinen, J; Tiihonen, J; Hodgins, S. 2018. Scientific reports. 8: 1101

Antiepileptic Drug Use and the Risk of Stroke Among Community-Dwelling People With Alzheimer Disease: A Matched Cohort Study

Sarycheva, Tatyana; Lavikainen, Piia; Taipale, Heidi; Tiihonen, Jari; Tanskanen; Antti; Hartikainen, Sirpa; Tolppanen, Anna-Maija. 2018. Journal of the american heart association. Cardiovascular and cerebrovascular disease. 7: e009742

Antipsychotic Use and the Risk of Initiating Medication for Benign Prostate Hyperplasia in Persons With Alzheimer Disease: A Matched Cohort Study

Orsel, Kim; Taipale, Heidi; Raatikainen, Sami; Lampela, Pasi; Tolppanen, Anna-Maija; Koponen, Marjaana; Tanskanen, Antti; Tiihonen, Jari; Gardarsdottir, Helga; Hartikainen, Sirpa. 2018. Journal of clinical psychopharmacology. 38: 494-497

Antipsychotics and mortality in a nationwide cohort of 29,823 patients with schizophrenia

Taipale, Heidi; Mittendorfer-Rutz, Ellenor; Alexanderson, Kristina; Majak, Maila; Mehtälä, Juha; Hoti, Fabian; Jedenius, Erik; Enkusson, Dana; Leval, Amy; Sermon, Jan; Tanskanen, Antti; Tiihonen, Jari. 2018. Schizophrenia research. 197: 274-280

Associations between MAOA-uVNTR genotype, maltreatment, MAOA methylation and alcohol consumption in young adult males

Bendre, Megha; Comasco, Erika; Checknita, Dave; Tiihonen, Jari; Hodgins, Sheilagh; Nilsson, Kent W. 2018. Alcoholism-clinical and experimental research. 42: 508-519

Associations of Psychopathic Traits With Local and Global Brain Network Topology in Young Adult Women

Lindner, Philip; Flodin, Pär; Budhiraja, Meenal; Savic, Ivanka; Jokinen, Jussi; Tiihonen, Jari; Hodgins, Sheilagh. 2018. Biological psychiatry : cognitive neuroscience and neuroimaging. 3: 1003-1012

Associations of monoamine oxidase A gene first exon methylation with sexual abuse and current depression in women

Checknita, David; Ekström, Tomas J; Comasco, Erika; Nilsson, Kent W; Tiihonen, Jari; Hodgins, Sheilagh. 2018. Journal of neural transmission. 125: 1053-1064

Bentsodiatsepiinien pitkäaikaiskäyttö on vähentynyt

Kurko, Terhi; Saastamoinen, Leena; Tuulio-Henriksson, Annamari; Taiminen, Tero; Tiihonen, Jari; Airaksinen, Marja; Hietala, Jarmo. 2018. Lääkärilehti. 73: 1292-1299

Burden for Parents of Patients With Schizophrenia - A Nationwide Comparative Study of Parents of Offspring With Rheumatoid Arthritis, Multiple Sclerosis, Epilepsy, and Healthy Controls

Mittendorfer-Rutz, Ellenor; Rahman, Syed; Tanskanen, Anti; Majak, Maila; Mehtälä, Juha; Hoti, Fabian; Jedenius, Erik; Enkusson, Dana; Leval, Amy; Sermon, Jan; Taipale, Hedi; Tiihonen, Jari. 2018. Schizophrenia bulletin. [Published: 03 September 2018]: 1-10

Cause-specific mortality in Finnish forensic psychiatric patients

Ojansuu, Ilkka; Putkonen, Hanna; Tiihonen, Jari. 2018. Nordic journal of psychiatry. 72: 374-379

Comorbid opioid use is undertreated among forensic patients with schizophrenia

Kivimies, Kristiina; Repo-Tiihonen, Eila; Kautiainen, Hannu; Tiihonen, Jari. 2018. Substance abuse treatment, prevention, and policy. 13: 39

Comparison of dispensed medications and forensic-toxicological findings to assess pharmacotherapy in the Swedish population 2006 to 2013

Forsman, J; Taipale, H; Masterman, T; Tiihonen, J; Tanskanen, A. 2018. Pharmacoepidemiology and drug safety. 27: 1112-1122

Concomitant use of benzodiazepines and opioids in community-dwelling older people with or without Alzheimer's disease - A nationwide register-based study in Finland

Karttunen, Niina; Taipale, Heidi; Hamina, Aleksi; Tanskanen, Antti; Tiihonen, Jari; Tolppanen, Anna-Maija; Hartikainen, Sirpa. 2018. International journal of geriatric psychiatry. 2019; 34: 280-288

Cortical structure abnormalities in females with conduct disorder prior to age 15

Budhiraja, M; Pereira, JB; Lindner, P; Westman, E; Jokinen, J; Savic, I; Tiihonen, J; Hodgins, S. 2018. Psychiatry research: neuroimaging. 2019; 289: 37-44

Determinants of hospitalizations for pneumonia among Finnish drug users

Olubamwo, OO; Onyeka, IN; Aregbesola, A; Ronkainen, K; Tiihonen, J; Föhr, J; Kauhanen, J. 2018. SAGE Open Medicine. 6: 1-7

Diabetes hospitalizations and deaths in a cohort of treatment-seeking illicit drug users

Aregbesola, Alex; Onyeka, Ifeoma N; Olubamwo, Olubunmi; Ronkainen, Kimmo; Tiihonen, Jari; Föhr, Jaana; Kauhanen, Jussi. 2018. SAGE Open Medicine. 6: 1-5

Duration of new antidepressant use and factors associated with discontinuation among community-dwelling persons with Alzheimer's disease

Kettunen, Reetta; Taipale, Heidi; Tolppanen, Anna-Maija; Tanskanen, Antti; Tiihonen, Jari; Hartikainen, Sirpa; Koponen, Marjaana. 2018. European journal of clinical pharmacology. 2019; 75: 417-425

Editorial: let's take a break from studying the PPI-fracture association - Authors' reply

Torvinen-Kiiskinen, S; Tolppanen, AM; Koponen, M; Tanskanen, A; Tiihonen, J; Hartikainen, S; Taipale, H. 2018. Alimentary pharmacology and therapeutics. 47: 1544-1545

Hospitalization after Oral Antibiotic Initiation in Finnish Community Dwellers with and without Alzheimer's Disease: Retrospective Register-Based Cohort Study

Järvinen, Heli; Taipale, Heidi; Koponen, Marjaana; Tanskanen, Antti; Tiihonen, Jari; Tolppanen, Anna-Maija; Hartikainen, Sirpa. 2018. Journal of Alzheimer's disease. 64: 437-445

Impact of opioid initiation on antipsychotic and benzodiazepine and related drug use among persons with Alzheimer's disease

Hamina, Aleksi; Lavikainen, Piia; Tanskanen, Antti; Tolppanen, Anna-Maija; Tiihonen, Jari; Hartikainen, Sirpa; Taipale, Heidi. 2018. International psychogeriatrics. 30: 947-956

Incidence and Prevalence of Antiepileptic Medication Use in Community-Dwelling Persons with and without Alzheimer's Disease

Sarycheva, Tatyana; Taipale, Heidi; Lavikainen, Piia; Tiihonen, Jari; Tanskanen, Antti; Hartikainen, Sirpa; Tolppanen, Anna-Maija. 2018. Journal of Alzheimer's disease. 66: 387-395

Incident opioid use and risk of hip fracture among persons with Alzheimer's disease, a nationwide matched cohort study

Taipale, Heidi; Hamina, Aleksi; Karttunen, Niina; Koponen, Marjaana; Tanskanen, Antti; Tiihonen, Jari; Hartikainen, Sirpa; Tolppanen, Anna-Maija. 2018. Pain. 2019; 160: 417-423

Initiation and long-term use of benzodiazepines and Z-drugs in bipolar disorder

Wingård, Louise; Taipale, Heidi; Reutfors, Johan; Westerlund, Anna; Bodén, Robert; Tiihonen, Jari; Tanskanen, Antti; Andersen, Morten. 2018. Bipolar disorders. 20: 634-646

Kuinka pitkään psykoosilääkettä uusille skitsofreniapotilaille?

Tiihonen, Jari; Tanskanen, Antti; Taipale, Heidi. 2018. Duodecim. 134: 1044

Mortality in schizophrenia: 30-year nationwide follow-up study

Tanskanen, A; Tiihonen, J; Taipale, H. 2018. Acta psychiatrica scandinavica. 138: 492-499

Nurses' Views Highlight a Need for the Systematic Development of Patient Safety Culture in Forensic Psychiatry Nursing

Kuosmanen, Anssi; Tiihonen, Jari; Repo-Tiihonen, Eila; Eronen, Markku; Turunen, Hannele. 2018. Journal of patient safety. [Epub ahead of print 4 Nov 2017]: 1-6

Proton pump inhibitor use and risk of hip fractures among community-dwelling persons with Alzheimer's disease - a nested case-control study

Torvinen-Kiiskinen, S; Tolppanen, AM; Koponen, M; Tanskanen, A; Tiihonen, J; Hartikainen, S; Taipale, H. 2018. Alimentary pharmacology and therapeutics. 47: 1135-1142

Psychopharmacological treatment, mortality and suicide in bipolar disorder in a Finnish nationwide cohort of 18,018 patients

Lähteenvuo, Markku; Antolín-Concha, Diego; Vattulainen, Pia, Tanskanen, Antti; Taipale, Heidi; Tiihonen, Jari. 2018. Psychiatria Fennica. 49: 10-21

Psychotropic drugs use and psychotropic polypharmacy among persons with Alzheimer's disease

Orsel, Kim; Taipale, Heidi; Tolppanen, Anna-Maija; Koponen, Marjaana; Tanskanen, Antti; Tiihonen, Jari; Gardarsdottir, Helga; Hartikainen, Sirpa. 2018. European neuropsychopharmacology. 28: 1260-1269

Real-world Effectiveness of Pharmacologic Treatments for the Prevention of Rehospitalization in a Finnish Nationwide Cohort of Patients With Bipolar Disorder

Lähteenvuo, Markku; Tanskanen, Antti; Taipale, Heidi; Hoti, Fabian; Vattulainen, Pia; Vieta, Eduard; Tiihonen, Jari. 2018. JAMA psychiatry. 75: 347-355

Response to the editorial on antipsychotics and mortality in a nationwide cohort of 29,823 patients with schizophrenia

Tiihonen, Jari. 2018. Schizophrenia research. 202: 397

Risk of Treatment Failure: Response to Czobor and Volavka

Tiihonen, Jari; Tanskanen, Antti; Taipale, Heidi. 2018. American journal of psychiatry. 175: 909

Risk of Treatment Failure: Response to Ghosh and Noble

Tiihonen, Jari; Tanskanen, Antti; Taipale, Heidi. 2018. American journal of psychiatry. 175: 1267

Systemic Estrogen Use and Discontinuation After Alzheimer's Disease Diagnosis in Finland 2005-2012: A Nationwide Exposure-Matched Cohort Study

Tolppanen, Anna-Maija; Tiihonen, Miia; Taipale, Heidi; Koponen, Marjaana; Tanskanen, Antti; Lavikainen, Piia; Tiihonen, Jari; Hartikainen, Sirpa. 2018. Drugs and aging. 35: 985-992

The risk of Alzheimer's disease associated with benzodiazepines and related drugs: a nested case-control study

Tapiainen, V; Taipale, H; Tanskanen, A; Tiihonen, J; Hartikainen, S; Tolppanen, A-M. 2018. Acta psychiatrica scandinavica. 138: 91-100

Trends in the long-term use of benzodiazepine anxiolytics and hypnotics: A national register study for 2006 to 2014

Kurko, Terhi; Saastamoinen, Leena K; Tuulio-Henriksson, Annamari; Taiminen, Tero; Tiihonen, Jari; Airaksinen, Marja; Hietala, Jarmo. 2018. Pharmacoepidemiology and drug safety. 27: 674-682

Use of antiepileptic drugs and dementia risk - an analysis of Finnish health register and German health insurance data

Taipale, H; Gomm, W; Broich, K; Maier, W; Tolppanen, AM; Tanskanen, A; Tiihonen, J; Hartikainen, S; Haenisch, B. 2018. Journal of the american geriatrics society. 66: 1123-1129

Antidepressant use and risk of hip fractures among community-dwelling persons with and without Alzheimer's disease

Torvinen-Kiiskinen Sanna, Tolppanen Anna-Maija, Koponen Marjaana, Tanskanen Antti, Tiihonen Jari, Hartikainen Sirpa, Taipale Heidi. 2017. International journal of geriatric psychiatry. 32: e107-e115

Antipsychotic use and the risk of hip fracture among community-dwelling persons with Alzheimer's disease

Koponen M, Taipale H, Lavikainen P, Tanskanen A, Tiihonen J, Tolppanen AM, Ahonen R, Hartikainen S. 2017. Journal of clinical psychiatry. 78: e257-e263

Association between route of illicit drug administration and hospitalizations for infective endocarditis

Olubamwo O, Onyeka IN, Aregbesola A, Ronkainen K, Tiihonen J, Föhr J, Kauhanen J. 2017. SAGE Open Medicine. 5: 1-5

Brain structure abnormalities in young women who presented conduct disorder in childhood/adolescence

Budhiraja Meenal, Savic Ivanka, Lindner Philip, Jokinen Jussi, Tiihonen Jari, Hodgins Sheilagh. 2017. Cognitive affective and behavioral neuroscience. 17: 869-885

Comparative Effectiveness of Antipsychotic Drugs for Rehospitalization in Schizophrenia-A Nationwide Study With 20-Year Follow-up

Taipale Heidi, Mehtälä Juha, Tanskanen Antti, Tiihonen Jari. 2017. Schizophrenia bulletin. Published: 20 December 2017: 1-7

De-escalation techniques used, and reasons for seclusion and restraint, in a forensic psychiatric hospital

Kuivalainen S, Vehviläinen-Julkunen K, Louheranta O, Putkonen A, Repo-Tiihonen E, Tiihonen J. 2017. International journal of mental health nursing. 26: 513-524

Drug exposure in register-based research - An expert-opinion based evaluation of methods

Tanskanen A, Taipale H, Koponen M, Tolppanen AM, Hartikainen S, Ahonen R, Tiihonen J. 2017. PLoS ONE. 12: e0184070

Firesetting and general criminal recidivism among a consecutive sample of Finnish pretrial male firesetters: A register-based follow-up study

Thomson A, Tiihonen J, Miettunen J, Virkkunen M, Lindberg N. 2017. Psychiatry research. 2018; 259: 377-384

Genome-wide association studies of a broad spectrum of antisocial behavior

Tielbeek JJ, Johansson A, Polderman TJC, Rautiainen MR, Jansen P, Taylor M, Tong X, Lu Q, Burt AS, Tiemeier H, Viding E, Plomin R, Martin NG, Heath AC, Madden PAF, Montgomery G, Beaver KM, Waldman I, Gelernter J, Kranzler HR et al.. 2017. JAMA psychiatry. 74: 1242-1250

Healthcare use among immigrants and natives in Sweden on disability pension, before and after changes of regulations

Di Thiene D, Rahman S, Helgesson M, Wang M, Alexanderson K, Tiihonen J, La Torre G, Mittendorfer-Rutz E. 2017. European journal of public health. [Epub ahead of print 30 Nov 2017]: 1-7

Hospital-treated mental and behavioral disorders and risk of Alzheimer's disease: A nationwide nested case-control study

Tapiainen V, Hartikainen S, Taipale H, Tiihonen J, Tolppanen A-M. 2017. European psychiatry. 43: 92-98

Huumeiden terveysriskit Suomessa - voiko niitä hallita? HUUTI-tutkimuksen antia

Kauhanen Jussi, Tiihonen Jari. 2017. Duodecim. 133: 34-42

Incident Use of a Potentially Inappropriate Medication and Hip Fracture in Community-Dwelling Older Persons With Alzheimer's Disease

Hyttinen V, Taipale H, Tolppanen A-M, Tanskanen A, Tiihonen J, Hartikainen S, Valtonen H. 2017. Annals of pharmacotherapy. 51: 725-734

Is Alzheimer's Disease Associated with Previous Opioid Use?

Taipale H, Hamina A, Lampela P, Tanskanen A, Tiihonen J, Karttunen N, Tolppanen AM, Hartikainen S. 2017. Pain medicine. 2018; 19: 2115-2121

Long-term use of proton pump inhibitors among community-dwelling persons with and without Alzheimer's disease

Juntunen Heidi, Taipale Heidi, Tanskanen Antti, Tolppanen Anna-Maija, Tiihonen Jari, Hartikainen Sirpa, Tiihonen Miia. 2017. European journal of clinical pharmacology. 73: 1149-1158

No Association Between Proton Pump Inhibitor Use and Risk of Alzheimer's Disease

Taipale Heidi, Tolppanen Anna-Maija, Tiihonen Miia, Tanskanen Antti, Tiihonen Jari, Hartikainen Sirpa. 2017. American journal of gastroenterology. 112: 1802-1808

Pharmacological treatments and risk of readmission to hospital for unipolar depression in Finland: a nationwide cohort study

Tiihonen Jari, Tanskanen Antti, Hoti Fabian, Vattulainen Pia, Taipale Heidi, Mehtälä Juha, Lähteenvuo Markku. 2017. The Lancet Psychiatry. 4: 547-553

Platelet monoamine oxidase activity and interpersonal violence in male suicide attempters

Jokinen Jussi, Königsson Johan, Moberg Tomas, Jönsson Erik G, Tiihonen Jari, Nordström Peter, Oreland Lars, Åsberg Marie. 2017. Psychiatry research. 2018; 260: 173-176

Psychopathy and Mortality

Vaurio Olli, Repo-Tiihonen Eila, Kautiainen Hannu, Tiihonen Jari. 2017. Journal of forensic sciences. 2018; 63: 474-477

Real-World Effectiveness of Antipsychotic Treatments in a Nationwide Cohort of 29 823 Patients With Schizophrenia

Tiihonen Jari, Mittendorfer-Rutz Ellenor, Majak Maila, Mehtälä Juha, Hoti Fabian, Jedenius Erik, Enkusson Dana, Leval Amy, Sermon Jan, Tanskanen Antti, Taipale Heidi. 2017. JAMA psychiatry. 74: 686-693

Reducing the rehospitalization risk after a manic episode: A population based cohort study of lithium, valproate, olanzapine, quetiapine and aripiprazole in monotherapy and combinations

Wingård L, Bodén R, Brandt L, Tiihonen J, Tanskanen A, Kieler H, Andersen M, Reutfors J. 2017. Journal of affective disorders. 217: 16-23

Regional changes in psychotropic use among Finnish persons with newly diagnosed Alzheimer's disease in 2005-2011

Tolppanen A-M, Voutilainen A, Taipale H, Tanskanen A, Lavikainen P, Koponen M, Tiihonen J, Hartikainen S. 2017. PLoS ONE. 12: e0173450

Risk of Alzheimer's disease among users of postmenopausal hormonetherapy: A nationwide case-control study

Imtiaz B, Taipale H, Tanskanen A, Tiihonen M, Kivipelto M, Heikkinen A-M, Tiihonen J, Soininen H, Hartikainen S, Tolppanen A-M. 2017. Maturitas. 98: 7-13

Risk of death associated with new benzodiazepine use among persons with Alzheimer disease: A matched cohort study

Saarelainen Laura, Tolppanen Anna-Maija, Koponen Marjaana, Tanskanen Antti, Tiihonen Jari, Hartikainen Sirpa, Taipale Heidi. 2017. International journal of geriatric psychiatry. 2018; 33: 583-590

Risk of disability pension in first and second generation immigrants: the role of age and region of birth in a prospective population-based study from Sweden

Di Thiene D, Helgesson M, Alexanderson K, La Torre G, Tiihonen J, Mittendorfer-Rutz E. 2017. Bmc public health. 17: 931

Risk of head and traumatic brain injuries associated with antidepressant use among community-dwelling persons with Alzheimer's disease: a nationwide matched cohort study

Taipale Heidi, Koponen Marjaana, Tanskanen Antti, Lavikainen Piia, Sund Reijo, Tiihonen Jari, Hartikainen Sirpa, Tolppanen Anna-Maija. 2017. Alzheimer's research and therapy. 9: 59

Risk of pneumonia associated with incident benzodiazepine use among community-dwelling persons with Alzheimer's disease

Taipale Heidi, Tolppanen Anna-Maija, Koponen Marjaana, Tanskanen Antti, Lavikainen Piia, Sund Reijo, Tiihonen Jari, Hartikainen Sirpa. 2017. Canadian medical association journal. 189: E519-E529

Screening approach for identifying candidate drugs and drug-drug interactions related to hip fracture risk in persons with Alzheimer disease

Tolppanen A-M, Taipale H, Koponen M, Tanskanen A, Lavikainen P, Paananen J, Tiihonen J, Hartikainen S. 2017. Pharmacoepidemiology and drug safety. 26: 875-889

Seasonal variation of hospital violence, seclusion and restraint in a forensic psychiatric hospital

Kuivalainen Satu, Vehviläinen-Julkunen Katri, Louheranta Olavi, Putkonen Anu, Repo-Tiihonen Eila, Tiihonen Jari. 2017. International journal of law and psychiatry. 52: 1-6

The Association of Ambient Temperature and Violent Crime

Tiihonen Jari, Halonen Pirjo, Tiihonen Laura, Kautiainen Hannu, Storvik Markus, Callaway James. 2017. Scientific reports. 7: 6543

Trajectories and characteristics of work disability before and after acute myocardial infarction

Wang M, Vaez M, Dorner TE, Tiihonen J, Voss M, Ivert T, Mittendorfer-Rutz E. 2017. Heart. [Epub ahead of print 1 Sept 2017]: 1-9

Use of benzodiazepines and related drugs is associated with risk of stroke among persons with Alzheimer's disease

Taipale Heidi, Koponen Marjaana, Tanskanen Antti, Lavikainen Piia, Tolppanen Anna-Maija, Sund Reijo, Tiihonen Jari, Hartikainen Sirpa. 2017. International clinical psychopharmacology. 32: 135-141

Use of lithium in patients with unipolar depression - Author's reply

Tiihonen Jari. 2017. The Lancet Psychiatry. 4: 663

White matter correlates of psychopathic traits in a female community sample

Lindner P, Budhiraja M, Westerman J, Savic I, Jokinen J, Tiihonen J, Hodgins S. 2017. Social cognitive and affective neuroscience. 12: 1500-1510

A Comparison of Sex Differences in Psychotropic Medication Use in Older People with Alzheimer's Disease in the US and Finland

Moga Daniela C, Taipale Heidi, Tolppanen Anna-Maija, Tanskanen Antti, Tiihonen Jari, Hartikainen Sirpa, Wu Qishan, Jicha Gregory A, Gnjidic Danijela. 2016. Drugs and aging. 2017; 34: 55-65

Add-on mirtazapine improves orgasmic functioning in patients with schizophrenia treated with first-generation antipsychotics

Terevnikov V, Stenberg JH, Tiihonen J, Burkin M, Joffe G. 2016. Nordic journal of psychiatry. 2017; 71: 77-80

Agreement between PRE2DUP register data modeling method and comprehensive drug use interview among older persons

Taipale Heidi, Tanskanen Antti, Koponen Marjaana, Tolppanen Anna-Maija, Tiihonen Jari, Hartikainen Sirpa. 2016. Clinical epidemiology. 8: 363-371

Alueelliset erot sairaalapäivissä ja lääkekustannuksissa Alzheimerin tautia sairastavilla ja verrokeilla [English Summary: Regional differences in number of hospital days and drug costs in people with and without Alzheimer's disease]

Taipale Heidi, Tolppanen Anna-Maija, Purhonen Maija, Tanskanen Antti, Ahonen Riitta, Tiihonen Jari, Hartikainen Sirpa. 2016. Lääkärilehti. 71: 1613-1619a

Anticholinergic Exposure and Risk of Pneumonia in Persons with Alzheimer's Disease: A Nested Case-Control Study

Lampela Pasi, Tolppanen Anna-Maija, Tanskanen Antti, Tiihonen Jari, Hartikainen Sirpa, Taipale Heidi. 2016. Journal of Alzheimer's disease. 2017; 56: 119-128

Antipsychotic use and risk of hospitalization or death due to pneumonia in persons with and without Alzheimer's disease

Tolppanen Anna-Maija, Koponen Marjaana, Tanskanen Antti, Lavikainen Piia, Sund Reijo, Tiihonen Jari, Hartikainen Sirpa, Taipale Heidi. 2016. Chest. 150: 1233-1241

Association between routes of drug administration and all-cause mortality among drug users

Onyeka Ifeoma N, Basnet Sushil, Beynon Caryl M, Tiihonen Jari, Föhr Jaana, Kauhanen Jussi. 2016. Journal of substance use. 21: 559-565

Cognitive insight, clinical insight, and reasoning in schizophrenia: a pilot study in a forensic setting

Kuokkanen R, Lappalainen R, Repo-Tiihonen E, Tiihonen J, Aho-Mustonen K. 2016. Journal of forensic psychology practice. 16: 253-267

Cohort profile: the Finnish Medication and Alzheimer's disease (MEDALZ) study

Tolppanen Anna-Maija, Taipale Heidi, Koponen Marjaana, Lavikainen Piia, Tanskanen Antti, Tiihonen Jari, Hartikainen Sirpa. 2016. BMJ open. 6: e012100

Comparison of predictors of hip fracture and mortality after hip fracture in community-dwellers with and without Alzheimer's disease - exposure-matched cohort study

Tolppanen Anna-Maija, Taipale Heidi, Tanskanen Antti, Tiihonen Jari, Hartikainen Sirpa. 2016. Bmc geriatrics. 16: 204

Conduct disorder in females is associated with reduced corpus callosum structural integrity independent of comorbid disorders and exposure to maltreatment

Lindner P, Savic I, Sitnikov R, Budhiraja M, Liu Y, Jokinen J, Tiihonen J, Hodgins S. 2016. Translational psychiatry. 6: e714

Dementialääkkeitä käytetään esitettyä pidempään [Ajassa

Hartikainen Sirpa, Paananen Jussi, Taipale Heidi, Tanskanen Antti, Tiihonen Jari, Tolppanen Anna-Maija. 2016. Lääkärilehti. 71: 3003

Differences in analgesic use in community-dwelling persons with and without Alzheimer's disease

Hamina Aleksi, Taipale Heidi, Tanskanen Antti, Tolppanen Anna-Maija, Tiihonen Jari, Hartikainen Sirpa. 2016. European journal of pain. 2017; 21: 658-667

Drug use in persons with and without Alzheimer's disease aged 90 years or more

Taipale Heidi, Koponen Marjaana, Tanskanen Antti, Tolppanen Anna-Maija, Tiihonen Jari, Hartikainen Sirpa. 2016. Age and ageing. 45: 900-904

Effects of Scheduled Waiting for Psychotherapy in Patients With Major Depression

Ahola P, Joensuu M, Knekt P, Lindfors O, Saarinen P, Tolmunen T, Valkonen-Korhonen M, Jääskeläinen T, Virtala E, Tiihonen J, Lehtonen J. 2016. Journal of nervous and mental disease. 205: 611-617

Fire-setting performed in adolescence or early adulthood predicts schizophrenia: a register-based follow-up study of pre-trial offenders

Thomson A, Tiihonen J, Miettunen J, Virkkunen M, Lindberg N. 2016. Nordic journal of psychiatry. 2017; 71: 96-101

Genome-wide association study of antisocial personality disorder

Rautiainen M-R, Paunio T, Repo-Tiihonen E, Virkkunen M, Ollila HM, Sulkava S, Jolanki O, Palotie A, Tiihonen J. 2016. Translational psychiatry. 6: e883

Incidence and Duration of Cumulative Bisphosphonate Use among Community-Dwelling Persons with or without Alzheimer's Disease

Tiihonen Miia, Taipale Heidi, Tanskanen Antti, Tiihonen Jari, Hartikainen Sirpa. 2016. Journal of Alzheimer's disease. 52: 127-132

Incidence of antidepressant use in community-dwelling persons with and without Alzheimer's disease: 13-year follow-up

Puranen Arto, Taipale Heidi, Koponen Marjaana, Tanskanen Antti, Tolppanen Anna-Maija, Tiihonen Jari, Hartikainen Sirpa. 2016. International journal of geriatric psychiatry. 2017; 32: 94-101

Increased steroid hormone dehydroepiandrosterone and pregnenolone levels in post-mortem brain samples of alcoholics

Kärkkäinen Olli, Häkkinen Merja R, Auriola Seppo, Kautiainen Hannu, Tiihonen Jari, Storvik Markus. 2016. Alcohol. 52: 63-70

Influence of a HTR2B stop codon on glucagon homeostasis and glucose excursion in non-diabetic men

Tikkanen R, Saukkonen T, Fex M, Bennet H, Rautiainen MR, Paunio T, Koskinen M, Panarsky R, Bevilacqua L, Sjöberg RL, Tiihonen J, Virkkunen M. 2016. Experimental and clinical endocrinology and diabetes. 124: 529-534

Long-term use of opioids for non-malignant pain among community-dwelling persons with and without Alzheimer disease in Finland: a nationwide register-based study

Hamina Aleksi, Taipale Heidi, Tanskanen Antti, Tolppanen Anna-Maija, Karttunen Niina, Pylkkänen Liisa, Tiihonen Jari, Hartikainen Sirpa. 2016. Pain. 2017; 158: 252-260

Month and Season of Birth as a Risk Factor for Alzheimer's Disease: A Nationwide Nested Case-control Study

Tolppanen Anna-Maija, Ahonen Riitta, Koponen Marjaana, Lavikainen Piia, Purhonen Maija, Taipale Heidi, Tanskanen Antti, Tiihonen Jari, Tiihonen Miia, Hartikainen Sirpa. 2016. Journal of preventive medicine and public health. 49: 134-138

Mortality and cumulative exposure to antipsychotics, antidepressants, and benzodiazepines in patients with schizophrenia: an observational follow-up study

Tiihonen J, Mittendorfer-Rutz E, Torniainen M, Alexanderson K, Tanskanen A. 2016. American journal of psychiatry. 173: 600-6

Nurses' Time Use in Forensic Psychiatry: Core Interventions Outlined in the Finnish Clinical Practice Guideline on Schizophrenia

Tenkanen Helena, Taskinen Helena, Kontio Raija, Repo-Tiihonen Eila, Tiihonen Jari, Kinnunen Juha. 2016. Journal of forensic nursing. 12: 64-73

Psykoosilääkkeet yhteydessä Alzheimer-potilaiden keuhkokuumeriskiin

Tolppanen Anna-Maija, Koponen Marjaana, Tanskanen Antti, Lavikainen Piia, Sund Reijo, Tiihonen Jari, Hartikainen Sirpa, Taipale Heidi. 2016. Duodecim. 132: 1490

Real-world effectiveness of antipsychotics

Tiihonen Jari. 2016. Acta psychiatrica scandinavica. 134: 371-373

Risk Factors for Initiation of Potentially Inappropriate Medications in Community-Dwelling Older Adults with and without Alzheimer's Disease

Hyttinen Virva, Taipale Heidi, Tanskanen Antti, Tiihonen Jari, Tolppanen Anna-Maija, Hartikainen Sirpa, Valtonen Hannu. 2016. Drugs and aging. 2017; 34: 67-77

Risk of Hip Fracture in Benzodiazepine Users With and Without Alzheimer Disease

Saarelainen Laura, Tolppanen Anna-Maija, Koponen Marjaana, Tanskanen Antti, Sund Reijo, Tiihonen Jari, Hartikainen Sirpa, Taipale Heidi. 2016. Journal of the american medical directors association. 2017; 18: 87.e15-87.e21

Risk of Mortality associated with Antipsychotic Monotherapy and Polypharmacy among Community-Dwelling Persons with Alzheimer's Disease

Koponen Marjaana, Taipale Heidi, Lavikainen Piia, Tanskanen Antti, Tiihonen Jari, Tolppanen Anna-Maija, Ahonen Riitta, Hartikainen Sirpa. 2016. Journal of Alzheimer's disease. 2017; 56: 107-118

The effects of a HTR2B stop codon and testosterone on energy metabolism and beta cell function among antisocial Finnish males

Tikkanen R, Saukkonen T, Fex M, Bennet H, Rautiainen MR, Paunio T, Koskinen M, Panarsky R, Bevilacqua L, Sjöberg RL, Tiihonen J, Virkkunen M. 2016. Journal of psychiatric research. Jun 25;81: 79-86

Use of antidementia drugs and risk of pneumonia in older persons with Alzheimer's disease

Lampela Pasi, Tolppanen Anna-Maija, Tanskanen Antti, Tiihonen Jari, Lavikainen Piia, Hartikainen Sirpa, Taipale Heidi. 2016. Annals of medicine. 2017; 49: 230-239

A pilot study of group administered metacognitive training (MCT) for schizophrenia patients in a high-security forensic setting: subjective training success and health-related quality of life

Kuokkanen Riitta, Aho-Mustonen Kati, Muotka Joona, Lappalainen Raimo, Tiihonen Jari. 2015. Journal of forensic psychology practice. 15: 344-362

Antipsychotic Treatment and Mortality in Schizophrenia

Torniainen Minna, Mittendorfer-Rutz Ellenor, Tanskanen Antti, Bjorkenstam Charlotte, Suvisaari Jaana, Alexanderson Kristina, Tiihonen Jari. 2015. Schizophrenia bulletin. 41: 656-663

Baseline symptom severity predicts serotonin transporter change during psychotherapy in patients with major depression

Joensuu M, Ahola P, Knekt P, Lindfors O, Saarinen P, Tolmunen T, Valkonen-Korhonen M, Vanninen R, Jääskeläinen T, Virtala E, Kuikka J, Tiihonen J, Lehtonen J. 2015. Psychiatry and clinical neurosciences. 2016; 70: 34-41

Characteristics of drug-abusing females with and without children seeking treatment in Helsinki, Finland

Basnet Sushil, Onyeka Ifeoma N, Tiihonen Jari, Föhr Jaana, Kauhanen Jussi. 2015. Scandinavian journal of public health. 43: 221-228

Decreased [³H]naloxone Binding in the Dentate Gyrus of Cloninger Type 1 Anxiety-Prone Alcoholics: A Postmortem Whole-Hemisphere Autoradiography Study

Laukkanen Virpi, Kärkkäinen Olli, Kautiainen Hannu, Tiihonen Jari, Storvik Markus. 2015. Alcoholism-clinical and experimental research. 39: 1352-1359

Factors associated with hospitalization for blood-borne viral infections among treatment-seeking illicit drug users

Onyeka Ifeoma N, Olubamwo Olubunmi, Beynon Caryl M, Ronkainen Kimmo, Föhr Jaana, Tiihonen Jari, Tuomola Pekka, Tasa Niko, Kauhanen Jussi. 2015. Journal of substance abuse treatment. 53: 71-77

From prescription drug purchases to drug use periods - a second generation method (PRE2DUP)

Tanskanen Antti, Taipale Heidi, Koponen Marjaana, Tolppanen Anna-Maija, Hartikainen Sirpa, Ahonen Riitta, Tiihonen Jari. 2015. Bmc medical informatics and decision making. 15: 21

Hospital care and drug costs from five years before until two years after the diagnosis of Alzheimer's disease in a Finnish nationwide cohort

Taipale Heidi, Purhonen Maija, Tolppanen Anna-Maija, Tanskanen Antti, Tiihonen Jari, Hartikainen Sirpa. 2015. Scandinavian journal of public health. 44(2016): 150-158

Hospital-treated suicide attempts among Finnish fire setters: A follow-up study

Thomson Annika, Tiihonen Jari, Miettunen Jouko, Virkkunen Matti, Lindberg Nina. 2015. Criminal behaviour and mental health. [epub ahead of print 17 AUG 2015]: -

Hospitalization in a Cohort Seeking Treatment for Illicit Drug Use in Finland

Onyeka Ifeoma N, Beynon Caryl M, Ronkainen Kimmo, Tiihonen Jari, Föhr Jaana, Kuikanmäki Outi, Paasolainen Mika, Kauhanen Jussi. 2015. Journal of substance abuse treatment. 53: 64-70

Impulsive alcohol-related risk-behavior and emotional dysregulation among individuals with a serotonin 2B receptor stop codon

Tikkanen R, Tiihonen J, Rautiainen MR, Paunio T, Bevilacqua L, Panarsky R, Goldman D, Virkkunen M. 2015. Translational psychiatry. 5: e681

Incidence of antipsychotic use in relation to diagnosis of Alzheimer's disease among community-dwelling persons

Koponen Marjaana, Tolppanen Anna-Maija, Taipale Heidi, Tanskanen Antti, Tiihonen Jari, Johnell Kristina, Fastbom Johan, Ahonen Riitta, Hartikainen Sirpa. 2015. British journal of psychiatry. 207: 444-449

Lithium is associated with decrease in all-cause and suicide mortality in high-risk bipolar patients: a nationwide registry-based prospective cohort study

Toffol Elena, Hätönen Taina, Tanskanen Antti, Lönnqvist Jouko, Wahlbeck Kristian, Joffe Grigori, Tiihonen Jari, Haukka Jari, Partonen Timo. 2015. Journal of affective disorders. 183: 159-165

Long-term use of antipsychotics among community-dwelling persons with Alzheimer's disease: A nationwide register-based study

Koponen Marjaana, Taipale Heidi, Tanskanen Antti, Tolppanen Anna-Maija, Tiihonen Jari, Ahonen Riitta, Hartikainen Sirpa. 2015. European neuropsychopharmacology. 25: 1706-1713

Long-term use of benzodiazepines and related drugs among community-dwelling individuals with and without Alzheimer's disease

Taipale Heidi, Koponen Marjaana, Tanskanen Antti, Tolppanen Anna-Maija, Tiihonen Jari, Hartikainen Sirpa. 2015. International clinical psychopharmacology. 30: 202-208

Long-term use of benzodiazepines: Definitions, prevalence and usage patterns - a systematic review of register-based studies

Kurko TAT, Saastamoinen LK, Tähkäpää T, Tuulio-Henriksson A, Taiminen T, Tiihonen J, Airaksinien MS, Hietala J. 2015. European psychiatry. 30: 1037-1047

Mortality among forensic psychiatric patients in Finland

Ojansuu Ilkka, Putkonen Hanna, Tiihonen Jari. 2015. Nordic journal of psychiatry. 69: 25-27

Opioid abuse and hospitalization rates in patients with schizophrenia

Kivimies Kristiina, Repo-Tiihonen Eila, Kautiainen Hannu, Maaranen Päivi, Muhonen Leea H., Heikkinen Martti , Tiihonen Jari. 2015. Nordic journal of psychiatry. 2016; 70: 128-132

Potential Years of Life Lost Due to Premature Mortality Among Treatment-Seeking Illicit Drug Users in Finland

Onyeka Ifeoma N, Beynon Caryl M, Vohlonen Ilkka, Tiihonen Jari, Föhr Jaana, Ronkainen Kimmo, Kauhanen Jussi. 2015. Journal of community health. 40: 1099-1106

Predictors for initiation of pharmacological prophylaxis in patients with newly diagnosed bipolar disorder - A nationwide cohort study

Scheen Louise, Brandt Lena, Boden Robert, Tiihonen Jari, Andersen Morten, Kieler Helle, Reutfors Johan. 2015. Journal of affective disorders. 172: 204-210

Prevalence of Drug Combinations Increasing Bleeding Risk Among Warfarin Users With and Without Alzheimer's Disease

Taipale Heidi, Vuorikari Hanna, Tanskanen Antti, Koponen Marjaana, Tiihonen Jari, Kettunen Raimo, Hartikainen Sirpa. 2015. Drugs and aging. 32: 937-945

Psychopathic traits among a consecutive sample of Finnish pretrial fire-setting offenders

Thomson Annika, Tiihonen Jari, Miettunen Jouko, Sailas Eila, Virkkunen Matti, Lindberg Nina. 2015. Bmc psychiatry. 15: 44

Psychotropic drugs and homicide: A prospective cohort study from Finland

Tiihonen Jari, Lehti Martti, Aaltonen Mikko, Kivivuori Janne, Kautiainen Hannu, Virta Lauri J., Hoti Fabian, Tanskanen Antti, Korhonen Pasi. 2015. World psychiatry. 14: 245-247

The Incidence of Benzodiazepine and Related Drug Use in Persons with and without Alzheimer's Disease

Saarelainen Laura, Taipale Heidi, Koponen Marjaana, Tanskanen Antti, Tolppanen Anna-Maija, Tiihonen Jari, Hartikainen Sirpa. 2015. Journal of Alzheimer's disease. 2016; 49: 809-818

Aivosairaudet ovat kalleimmat kansantautimme

Lindsberg Perttu J, Castrén Eero, Korkeila Jyrki, Alho Hannu, Erkinjuntti Timo, Isometsä Erkki, Kalso Eija, Marttunen Mauri, Pihko Helena, Tienari Pentti, Wartiovaara Anu, Jäkälä Pekka, Kälviäinen Reetta, Soininen Hilkka, Tiihonen Jari, Karlsson Hasse, Rinne Juha, Roine Risto O, Elovaara Irina, Tamminen Tuula, Öhman Juha, Majamaa Kari, Hari Riitta. 2014. Duodecim. 130: 1721-1730

Antidementia drug use among community-dwelling individuals with Alzheimer's disease in Finland: a nationwide register-based study

Taipale Heidi, Tanskanen Antti, Koponen Marjaana, Tolppanen Anna-Maija, Tiihonen Jari, Hartikainen Sirpa. 2014. International clinical psychopharmacology. 29: 216-223

Antipsychotic Doses Among Community-Dwelling Persons With Alzheimer Disease in Finland

Taipale Heidi, Koponen Marjaana, Tanskanen Antti, Tolppanen Anna-Maija, Tiihonen Jari, Hartikainen Sirpa. 2014. Journal of clinical psychopharmacology. 34: 435-440

Antipsychotic Polypharmacy among a Nationwide Sample of Community-Dwelling Persons with Alzheimer's Disease

Taipale Heidi, Koponen Marjaana, Tanskanen Antti, Tolppanen Anna-Maija, Tiihonen Jari, Hartikainen Sirpa. 2014. Journal of Alzheimer's disease. 41: 1223-1228

Association of socio-demographic factors, sick-leave and health care patterns with the risk of being granted a disability pension among psychiatric outpatients with depression

Mittendorfer-Rutz E, Härkänen T, Tiihonen J, Haukka J. 2014. PLoS ONE. 9: e99869

Basal insulin secretion, PCL-R and recidivism among impulsive violent alcoholic offenders

Ojala Kari PT, Tiihonen Jari, Repo-Tiihonen Eila, Tikkanen Roope, Virkkunen Matti. 2014. Psychiatry research. 225: 420-424

Concomitant Use of Acetylcholine Esterase Inhibitors and Urinary Antispasmodics Among Finnish Community-Dwelling Persons With Alzheimer Disease

Torvinen-Kiiskinen Sanna, Taipale Heidi, Tanskanen Antti, Tiihonen Jari, Hartikainen Sirpa. 2014. Journal of clinical psychopharmacology. 34: 722-727

Factors associated with buprenorphine compared to amphetamine abuse among clients seeking treatment in Finland

Uosukainen Hanna, Ilomäki Jenni, Kauhanen Jussi, Tacke Ulrich, Föhr Jaana, Tiihonen Jari, Bell J. Simon. 2014. Journal of substance abuse treatment. 46: 561-566

From prescriptions to drug use periods - things to notice

Tanskanen Antti, Taipale Heidi, Koponen Marjaana, Tolppanen Anna-Maija, Hartikainen Sirpa, Ahonen Riitta, Tiihonen Jari. 2014. Bmc research notes. 7: 796

Genetic background of extreme violent behavior

Tiihonen J, Rautiainen M-R, Ollila HM, Repo-Tiihonen E, Virkkunen M, Palotie A, Pietiläinen O, Kristiansson K, Joukamaa M, Lauerma H, Saarela J, Tyni S, Vartiainen H, Paananen J, Goldman D, Paunio T. 2014. Molecular psychiatry. 2015; 20: 786-792

High prevalence of psychotropic drug use among persons with and without Alzheimer's disease in Finnish nationwide cohort

Taipale Heidi, Koponen Marjaana, Tanskanen Antti, Tolppanen Anna-Maija, Tiihonen Jari, Hartikainen Sirpa. 2014. European neuropsychopharmacology. 24: 1729-1737

Increased metabotropic glutamate 2/3 receptor binding in the perigenual anterior cingulate cortex of Cloninger type 2 alcoholics: a whole-hemisphere autoradiography study

Laukkanen Virpi, Kärkkäinen Olli, Kupila Jukka, Kautiainen Hannu, Tiihonen Jari, Storvik Markus. 2014. Alcohol and alcoholism. 50 (2015): 62-67

Kun psyykenlääke vain katoaa

Purhonen Maija, Koponen Hannu, Tiihonen Jari, Tanskanen Antti. 2014. Duodecim. 130: 438-439

Lower [3H]Citalopram Binding in Brain Areas Related to Social Cognition in Alcoholics

Kärkkäinen Olli, Laukkanen Virpi, Haukijärvi Tuija, Kautiainen Hannu, Tiihonen Jari, Storvik Markus. 2014. Alcohol and alcoholism. 2015; 50: 46-50

Metacognitive group training for forensic and dangerous non-forensic patients with schizophrenia: A randomised controlled feasibility trial

Kuokkanen Riitta, Lappalainen Raimo, Repo-Tiihonen Eila, Tiihonen Jari. 2014. Criminal behaviour and mental health. 24: 345-357

Mortality of firesetters: A follow-up study of Finnish male firesetters who underwent a pretrial forensic examination in 1973-1998

Thomson Annika, Tiihonen Jari, Miettunen Jouko, Virkkunen Matti, Lindberg Nina. 2014. Psychiatry research. 225: 638-642

Oikeuspsykiatria

Tiihonen Jari. Teoksessa: Lönnqvist Jouko, Henriksson Markus, Marttunen Mauri, Partonen Timo(toim.) , 2014. Psykiatria. s. 697-715.

Patterns and 14-year trends in mortality among illicit drug users in Finland: The HUUTI study

Onyeka Ifeoma N, Beynon Caryl M, Hannila Marja-Leena, Tiihonen Jari, Föhr Jaana, Tuomola Pekka, Kuikanmäki Outi, Tasa Niko, Paasolainen Mika, Kauhanen Jussi. 2014. International journal of drug policy. 25: 1047-1053

Previous forensic mental examination is a useful marker indicating effective violence relapse prevention among psychotic patients

Kivimies Kristiina, Repo-Tiihonen Eila, Kautiainen Hannu, Tiihonen Jari. 2014. Nordic journal of psychiatry. 68: 311-315

Skitsofrenian käypä hoito -suosituksen toteuttaminen Niuvanniemen sairaalassa

Tuppurainen Heli, Kivistö Päivi, Repo-Tiihonen Eila, Tiihonen Jari. 2014. Lääkärilehti. 69: 2549-2553

The C90RF72 expansion does not affect the phenotype in Nasu-Hakola disease with the DAP12 mutation

Solje Eino, Hartikainen Päivi, Valori Miko, Vanninen Ritva, Tiihonen Jari, Hakola Panu, Tienari Pentti J, Remes Anne M. 2014. Neurobiology of aging. 35: 1780.e13-1780.e17

[3H]Ifenprodil binding in post-mortem brains of Cloninger type 1 and 2 alcoholics: A whole-hemisphere autoradiography study

Kupila Jukka, Kärkkäinen Olli, Laukkanen Virpi, Häkkinen Merja, Kautiainen Hannu, Tiihonen Jari, Storvik Markus. 2014. Psychiatry research: neuroimaging. 2015; 231: 197-201

AMPA receptors in post-mortem brains of Cloninger type 1 and 2 alcoholics: A whole-hemisphere autoradiography study

Kärkkäinen Olli, Kupila Jukka, Häkkinen Merja, Laukkanen Virpi, Tupala Erkki, Kautiainen Hannu, Tiihonen Jari, Storvik Markus. 2013. Psychiatry research: neuroimaging. 214: 429-434

Atypical nucleus accumbens morphology in psychopathy: Another limbic piece in the puzzle

Boccardi M, Bocchetta M, Aronen HJ, Repo-Tiihonen E, Vaurio O, Thompson PM, Tiihonen J, Frisoni GB. 2013. International journal of law and psychiatry. 36: 157-167

Cavum septum pellucidum and psychopathy

Toivonen P, Könönen M, Niskanen E, Vaurio O, Repo-Tiihonen E, Seppänen A, Aronen HJ, Vanninen R, Tiihonen J, Laakso MP. 2013. British journal of psychiatry. 203: 152-153

Cluster-randomized controlled trial of reducing seclusion and restraint in secured care of men with schizophrenia

Putkonen A, Kuivalainen S, Louheranta O, Repo-Tiihonen E, Ryynänen O-P, Kautiainen H, Tiihonen J. 2013. Psychiatric services. 64: 850-855

Coexisting social conditions and health problems among clients seeking treatment for illicit drug use in Finland: The HUUTI study

Onyeka Ifeoma N, Beynon Caryl M, Uosukainen Hanna, Korhonen Maarit J, Ilomäki Jenni, Bell J. Simon, Paasolainen Mika, Tasa Niko, Tiihonen Jari, Kauhanen Jussi. 2013. Bmc public health. 13: 380

Decreased GABA(A) benzodiazepine binding site densities in postmortem brains of Cloninger type 1 and 2 alcoholics

Laukkanen Virpi, Storvik Markus, Häkkinen Merja, Akamine Yumiko, Tupala Erkki, Virkkunen Matti, Tiihonen Jari. 2013. Alcohol. 47: 103-108

Description of long-term polypharmacy among schizophrenia outpatients

Suokas JT, Suvisaari JM, Haukka J, Korhonen P, Tiihonen J. 2013. Social psychiatry and psychiatric epidemiology. 48: 631-638

Endogenous cannabinoids in amygdala and hippocampus in post-mortem brains of Cloninger type 1 and 2 alcoholics

Kärkkäinen Olli K, Lehtonen Marko, Laukkanen Virpi, Tupala Erkki, Hyytiä Petri, Kautiainen Hannu, Tiihonen Jari, Callaway JC, Storvik Markus. 2013. Alcohol. 47: 399-403

Exome sequence analysis of Finnish patients with clozapine-induced agranulocytosis

Tiwari AK, Need AC, Lohoff FW, Zai CC, Chowdhury NI, Müller DJ, Putkonen A, Repo-Tiihonen E, Hallikainen T, Anil Yağcıoğlu AE, Tiihonen J, Kennedy JL, Meltzer HY. 2013. Molecular psychiatry. e-pub: e-pub

Extended-release methylphenidate for treatment of amphetamine/metamphetamine depence: a randomized, double-blind, placebo-controlled trial

Miles SW, Sheridan J, Russell B, Kydd R, Wheeler A, Walters C, Gamble G, Hardley P, Jensen M, Kuoppasalmi K, Tuomola P, Föhr J, Kuikanmäki O, Vorma H, Salokangas R, Mikkonen A, Kallio M, Kauhanen J, Kiviniemi V, Tiihonen J. 2013. Addiction. 108: 1279-86

Influence of serotonin transporter gene polymorphism (5-HTTLPR polymorphism) on the relation between brain 5-HT transporter binding and heart rate corrected cardiac repolarization interval

Kauppila E, Vanninen E, Kaurijoki S, Karhunen L, Pietiläinen KH, Rissanen A, Tiihonen J, Pesonen U, Kaprio J. 2013. PLoS ONE. 8: e50303

Letter to the Editor (Clozapine resistance - Augmentation strategies)

Tiihonen J, Leucht S. 2013. European neuropsychopharmacology. 23: 338

Mortality among clients seeking treatment for buprenorphine abuse in Finland. Erratum in Drug Alcohol Depend 2014: 142:361

Uosukainen Hanna, Kauhanen Jussi, Bell J. Simon, Ronkainen Kimmo, Tiihonen Jari, Föhr Jaana, Onyeka Ifeoma N, Korhonen Maarit J. 2013. Drug and alcohol dependence. 133: 391-397

Patient Safety Culture in Two Finnish State-Run Forensic Psychiatric Hospitals

Kuosmanen Anssi, Tiihonen Jari, Repo-Tiihonen Eila, Eronen Markku, Turunen Hannele. 2013. Journal of forensic nursing. Epub: 1-10

Predictors and mediators of add-on mirtazapine-induced cognitive enhancement in schizophrenia - A path model investigation

Stenberg J-H, Terevnikov V, Joffe M, Tiihonen J, Chukhin E, Burkin M, Joffe G. 2013. Neuropharmacology. 64: 248-253

Relationships between pharmacotherapy-induced metabolic changes and improved psychopathology in schizophrenia: data from a mirtazapine and first-generation antipsychotics combination trial

Terevnikov V, Stenberg J-H, Tiihonen J, Chukhin E, Joffe M, Burkin M, Joffe G. 2013. International journal of neuropsychopharmacology. 16: 1661-1666

Use of existing data sources in clinical epidemiology: Finnish health care registers in Alzheimer's disease research - the Medication use among persons with Alzheimer's disease (MEDALZ-2005) study

Tolppanen Anna-Maija, Taipale Heidi, Koponen Marjaana, Lavikainen Piia, Tanskanen Antti, Tiihonen Jari, Hartikainen Sirpa. 2013. Clinical epidemiology. 5: 277-285

Using the HCR-20 to predict aggressive behavior among men with schizophrenia living in the community: accuracy of prediction, general and forensic settings, and dynamic risk factors

Michel SF, Riaz M, Webster C, Hart SD, Levander S, Müller-Isberner R, Tiihonen J, Repo-Tiihonen E, Tuninger E, Hodgins S. 2013. International journal of forensic mental health. 12: 1-13

Violent behaviour in a forensic psychiatric hospital in Finland: an analysis of violence incident reports

Kuivalainen S, Vehviläinen-Julkunen K, Putkonen A, Louheranta O, Tiihonen J.. 2013. Journal of psychiatric and mental health nursing. : 1-5

Voisiko luonnon oma säilöntäaine mullistaa psykoosin hoidon?

Tiihonen J. 2013. Duodecim. 129: 2098-2099

Word list learning in patients with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy

Vanhanen M, Hakola P, Ilonen T, Tiihonen J. 2013. Dementia and geriatric cognitive disorders. 3: 10-15

Antipsychotic polypharmacy in clozapine resistant schizophrenia: a randomized controlled trial of tapering antipsychotic co-treatment

Repo-Tiihonen E, Hallikainen T, Kivistö P, Tiihonen J. 2012. Mental illness. 4: e1

Cardiovascular morbidity, mortality, and pharmacotherapy in patients with schizophrenia.

Lahti M, Tiihonen J, Wildgust H, Beary M, Hodgson R, Kajantie E, Osmond C, Räikkönen K, Eriksson JG. 2012. Psychological medicine. 42: 2275-2285

Examining the effectiveness of antipsychotic medication in first-episode psychosis

Taylor M, Cavanagh J, Hodgson R, Tiihonen J.. 2012. Journal of psychopharmacology. 26: 27-32

Exome sequencing followed by large-scale genotyping suggests a limited role for moderately rate risk factors of strong effect in schizophrenia

Need AC, McEvoy JP, Gennarelli M, Heinzen EL, Ge D, Maia JM, Shianna KV, He M, Cirulli ET, Gumbs CE, Zhao Q, Campbell CR, Hong L, Rosenquist P, Putkonen A, Hallikainen T, Repo-Tiihonen E, Tiihonen J, Levy DL, Meltzer HY, Goldstein DB. 2012. American journal of human genetics. 91: 303-312

Nalreksoni-implantti hyödyttää moniriippuvaisia huumeiden käyttäjiä

Tiihonen J, Krupitsky E, Verbitskaya E, Blokhina E, Mamontova O, Föhr J, Tuomola P, Kuoppasalmi K, Kiviniemi V, Zwartau E. 2012. Duodecim. 128: 830

Naltrexone implant for the treatment of polydrug dependence: a randomized controlled trial.

Tiihonen J, Krupitsky E, Verbitskaya E, Blokhina E, Mamontova O, Föhr J, Tuomola P, Kuoppasalmi K, Kiviniemi V, Zwartau E.. 2012. American journal of psychiatry. 169: 531-536

Outcome of patients after market withdrawal of thioridazine. A retrospective analysis in a nationwide cohort

Purhonen M, Koponen H, Tiihonen J, Tanskanen A. 2012. Pharmacoepidemiology and drug safety. 21: 1227-1231

Polypharmacy with antipsychotics, antidepressants, or benzodiazepines and mortality in schizophrenia

Tiihonen J, Suokas JT, Suvisaari JM, Haukka J, Korhonen P. 2012. Archives of general psychiatry. 69: 476-483

Potilasturvallisuuskulttuurin arviointi -kysely valtion oikeuspsykiatristen sairaaloiden henkilöstölle

Kuosmanen Anssi, Tiihonen Jari, Repo-Tiihonen Eila, Eronen Markku, Turunen Hannele. Teoksessa: Kääriäinen Maria, Elo Satu, Kaakinen Pirjo, Helvi Kyngäs(toim.) , 2012. Alakko nää mua? Yhteistyöllä vaikuttavaa hoitotieteellistä tutkimusta, XII Kansallinen hoitotieteellinen konferenssi 27.-28.9.2012, Oulun yliopisto, Proceedings. s. 49-53.

Reply to Drs. Nauta and van Domburg

Haukka J, Niskanen L, Partonen T, Lönnqvist J, Tiihonen J. 2012. Pharmacoepidemiology and drug safety. 21: 342

Rorschach assessment of personality functioning in patients with polycystic lipomembraneous osteodysplasia with sclerosing leukoencephalopathy

Ilonen T, Hakola HPA, Vanhanen M, Tiihonen J. 2012. Acta neuropsychiatrica. 24: 236-244

Sociodemographic characteristics and drug abuse patterns of treatment-seeking illicit drug abusers in Finland 1997-2008: The HUUTI study

Onyeka Ifeoma N, Uosukainen Hanna, Korhonen Maarit J, Beynon Caryl, Bell J Simon, Ronkainen Kimmo, Föhr Jaana, Tiihonen Jari, Kauhanen Jussi. 2012. Journal of addictive diseases. 31: 350-362

Statin usage and all-cause and disease-specific mortality in a nationwide study

Haukka J, Niskanen L, Partonen T, Lönnqvist J, Tiihonen J.. 2012. Pharmacoepidemiology and drug safety. 21: 61-69

The net effect of smoking on healthcare and welfare costs. A cohort study.

Tiihonen J, Ronkainen K, Kangasharju A, Kauhanen J. 2012. BMJ open. 2: e001678

The substance use of among forensic psychiatric patients

Kivimies K, Repo-Tiihonen E, Tiihonen J. 2012. American journal of drug and alcohol abuse. 38: 273-277

Toward molecular psychotherapy of depression?

Lehtonen J, Tiihonen J, Joensuu MMO, Lehto SM, Ahola PA, Saarinen PI, Valkonen-Korhonen M, Tolmunen T, Kuikka JT. Teoksessa: Levy RA, Ablon JS, Kächele H,(toim.) , 2012. Psychodynamic psychotherapy research: Evidence-based practice and practice-based evidence. s. 219-232. Humana Press

Twelve-year trend in treatment seeking for buprenorphine abuse in Finland

Uosukainen Hanna, Kauhanen Jussi, Voutilainen Sari, Föhr Jaana, Paasolainen Mika, Tiihonen Jari, Laitinen Kirsti, Onyeka Ifeoma N, Bell J Simon. 2012. Drug and alcohol dependence. 2013:127: 207-214

Use of benzodiazepines in adults with schizophrenia is associated with increased mortality

Tiihonen J, Suokas JT, Suvisaari JM. 2012. Evidence-based mental health. 15: 97

Whole-hemisphere autoradiography of 5-HT&#8321 B receptor densities in postmortem alcoholic brains

Storvik Markus, Häkkinen Merja, Tupala Erkki, Tiihonen Jari. 2012. Psychiatry research: neuroimaging. 202: 264-270

mGluR1/5 receptor densities in the brains of alcoholic subjects: A whole-hemisphere autoradiography study

Kupila Jukka, Kärkkäinen Olli, Laukkanen Virpi, Tupala Erkki, Tiihonen Jari, Storvik Markus. 2012. Psychiatry research: neuroimaging. 2013:212: 245-250

A nationwide cohort study of oral and depot antipsychotics after first hospitalization for schizophrenia

Tiihonen J, Haukka J, Taylor M, Haddad PM, Patel MX, Korhonen P. 2011. American journal of psychiatry. 168: 603-609

Add-on mirtazapine improves depressive symptoms in schizophrenia: a double-blind randomized placebo-controlled study with an open-label extension phase

Terevnikov V, Stenberg J-H, Tiihonen J, Joffe M, Burkin M, Tchoukhine E, Joffe G. 2011. Human psychopharmacology: clinical and experimental. 26: 188-193

Clinical relevance in Finnish population based studies in schzophrenia, with special reference to the Northern Finland 1966 Birth Cohort Study

Isohanni M, Miller B, Koivumaa H, Tiihonen J, Koponen H, Moilanen K, Tanskanen P, Penttilä M, Rannikko I, Culpepper N, Ghose S, Moilanen J, Rissanen I, Huhtaniska S, Ruonala P, Keskinen E, Hirvasniemi J, Leviäkangas A, Isohanni I, Alaräisänen A, Miettunen J, Jääskeläinen E. 2011. Psychiatria fennica. 42: 65-86

Cortex and amygdala morphology in psychopathy

Boccardi M, Frisoni GB, Hare RD, Cavedo E, MNajt P, Pievani M, Rasser PE, Laakso MP, Aronen HJ, Repo-Tiihonen E, Vaurio O, Thompson PM, Tiihonen J. 2011. Psychiatry research: neuroimaging. 193: 85-92

Costs of intensive psychiatric care for treatment-resistant minors

Paakkonen T, Tiihonen J, Paakkonen H, Hallikainen T, Ryynänen O-P, Kinnunen J. 2011. Journal of mental health policy and economics. 14: 149-156

Gender differences in brain serotonin transporter availability in panic disorder

Maron E, Tõru I, Hirvonen J, Tuominen L, Lumme V, Vasar V, Shlik J, Nutt DJ, Helin S, Någren K, Tiihonen J, Hietala J. 2011. Journal of psychopharmacology. 25: 952-959

Group psychoeducation for long-term offender patients with schizophrenia: An exploratory randomized controlled trial

Aho-Mustonen Kati, Tiihonen Jari, Repo-Tiihonen Eila, Ryynänen Olli-Pekka, Miettinen Raili & Räty Hannu. 2011. Criminal behaviour and mental health. 21: 163-176

Interrelationship between core interventions and core competencies of forensic psychiatric nursing in Finland

Tenkanen Helena, Tiihonen Jari, Repo-Tiihonen Eila, Kinnunen Juha. 2011. Journal of forensic nursing. 7: 32-39

Lastenpsykiatrian ja nuorisopsykiatrian erikoisalojen säilyttäminen on yhteiskunnallinen kysymys

Aalberg V, Arajärvi T, Haukkamaa K, Laukkanen E, Lehtonen J, Pylkkänen K, Taipale V, Tiihonen J. 2011. Lääkärilehti. 66: 3562-3563

More evidence on proneurocognitive effects of add-on mirtazapine in schizophrenia

Stenberg J-H, Terevnikov V, Joffe M, Tiihonen J, Tchoukhine E, Burkin M, Joffe G. 2011. Progress in neuro-psychopharmacology and biological psychiatry. 35: 1080-1086

Niuvanniemen nuoriso-osastolle ohjautuneiden potilaiden kotikuntien mielenterveyttä tukevien palvelujen tarjonta ja menot

Rissanen T, Tiihonen J, Paakkonen H, Hallikainen T, Ryynänen O-P, Kinnunen J. 2011. Sosiaalilääketieteellinen aikakauslehti. 48: 22-37

Oikeuspsykiatria

Tiihonen J. Teoksessa: Lönnqvist J, Henriksson M, Marttunen M, Partonen T(toim.) , 2011. Psykiatria. 9. uudistettu painos. s. 611-628.

Psychopathy, PCL-R, and MAOA genotype as predictors of violent reconvictions

Tikkanen R, Auvinen-Lintunen L, Ducci F, Sjöberg RL, Goldman D, Tiihonen J, Ojansuu I, Virkkunen M. 2011. Psychiatry research. 185: 382-386

Päivittäistavarakaupoissa myytävien juomien alkoholipitoisuuden alentamisen vaikutus alkoholin kulutukseen ja kuolemiin

Tiihonen Jari, Kangasharju Aki, Mäkelä Pia, Saari Juho, Österberg Esa. 2011. VATT valmisteluraportit. .

The patient- therapist interaction and the recognition of affects during the process of psychodynamic psychotherapy for depression

Ahola P, Valkonen-Korhonen M, Tolmunen T, Joensuu M, Lehto SM, Saarinen PI, Tiihonen J, Lehtonen J. 2011. American journal of psychotherapy. 65: 355-379

The place of observational studies in assessing the effectiveness of depot antipsychotics

Haddad PM, Tiihonen J, Haukka J, Taylor M, Patel MX, Korhonen P. 2011. Schizophrenia research. 131: 260-261

Abnormal hippocampal shape in offenders with psychopathy

Boccardi M, Ganzola R, Rossi R, Sabattoli F, Laakso MP, Repo-Tiihonen E, Vaurio O, Könönen M, Aronen HJ, Thompson PM, Frisoni GB, Tiihonen J. 2010. Human brain mapping. 31: 438-447

Dopamine transporter binding in females with panic disorder may vary with clinical status

Maron E, Nutt DJ, Kuikka J, Tiihonen J. 2010. Journal of psychiatric research. 44: 56-59

Effects of add-on mirtazapine on neurocognition in schisophrenia: a double-blind, randomized, placebo-controlled study

Stenberg J-H, Terevnikov V, Joffe M, Tiihonen J, Tchoukhine E, Burkin M, Joffe G. 2010. International journal of neuropsychopharmacology. 13: 433-441

Endogenous cannabinoids in post-mortem brains of Cloninger type 1 and 2 alcoholics

Lehtonen M, Storvik M, Tupala E, Hyytiä P, Tiihonen J & Callaway JC. 2010. European neuropsychopharmacology. 20: 245 - 252

Extrapyramidal side-effects and dopamine D2/3 receptor binding in substanta nigra

Tuppurainen H, Kuikka JT, Viinamäki H, Husso M, Tiihonen J. 2010. Nordic journal of psychiatry. 64: 233-238

Incidence of cancer and antidepressant medication: record linkage study

Haukka J, Sankila R, Klaukka T, Lonnqvist J, Niskanen L, Tanskanen J, Wahlbeck K & Tiihonen J. 2010. International journal of cancer. 126: 285-296

Incidence of cancer and statin usage - record linkage study

Haukka J, Sankila R, Klaukka T, Lonnqvist J, Niskanen L, Tanskanen A, Wahlbeck K &Tiihonen J. 2010. International journal of cancer. 126: 279-284

MAOA alters the effects of heavy drinking and childhood physical abuse on risk for severe impulsive acts of violence among alcoholic violent offenders

Tikkanen R, Ducci F, Goldman D, Holi M, Lindberg N, Tiihonen J, Virkkunen M. 2010. Alcoholism-clinical and experimental research. 35: 1-8

More evidence on additive antipsychotic effect of adjunctive mirtazapine in schizophrenia: an extension phase of a randomized controlled trial

Terevnikov V, Stenberg J-H, Joffe M, Tiihonen J, Burkin M, Tchoukhine E, Joffe G. 2010. Human psychopharmacology: clinical and experimental. 25: 431-438

Seasonal variation of seclusion incidents from violent and suicidal acts in forensic psychiatric patients

Paavola P, Tiihonen J. 2010. International journal of law and psychiatry. 33: 27-34

Serotonin-transporter-linked promoter region polymorphism and serotonin transporter binding in drug-naive patients with major depression

Joensuu M, Lehto SM, Tolmunen T, Saarinen PI, Valkonen-Korhonen M, Vanninen R, Ahola P, Tiihonen J, Kuikka J, Pesonen U, Lehtonen J. 2010. Psychiatry and clinical neurosciences. 64: 387-393

The intergenerational cycle of criminality - association with psychopathy

Repo-Tiihonen E, Tiihonen J, Lindberg N, Weizmann-Henelius G, Putkonen H, Häkkänen H. 2010. Journal of forensic sciences. 55: 116-120

11-year follow-up of mortality in patients with schizophrenia: a population-based cohort study (FIN11 study)

Tiihonen J, Lönnqvist J, Wahlbeck K, Klaukka T, Niskanen L, Tanskanen A, Haukka J. 2009. The Lancet. 374: 620-627

5-HT1A receptors in the frontal cortical brain areas in Cloninger type 1 and 2 alcoholics measured by whole-hemisphere autoradiography

Storvik M, Häkkinen M, Tupala E, Tiihonen J. 2009. Alcohol and alcoholism. 44: 2-7

Add-on mirtazapine enhances antipsychotic effect of first generation antipsychotics in schizophrenia: A double-blind, randomized, placebo-controlled trial

Joffe G, Terevnikov V, Joffe M, Stenberg J-H, Burkin M, Tiihonen J. 2009. Schizophrenia research. 108: 245-251

Altered hemispheric balance of temporal cortex dopamine D2/3 receptor binding in major depressive disorder

Lehto SM, Kuikka J, Tolmunen T, Hintikka J, Viinamäki H, Vanninen R, Koivumaa-Honkanen H, Honkalampi K, Tiihonen J. 2009. Psychiatry research: neuroimaging

Antidepressant use and mortality in Finland: a register-linkage study from a nationwide cohort

Haukka J, Arffman M, Partonen T, Sihvo S, Elovainio M, Tiihonen J, Lönnqvist J, Keskimäki I. 2009. European journal of clinical pharmacology. 65: 715-720

Author's reply (to 11-year follow-up study of mortality in patients with schizophrenia: a population-based cohort study (FIN11 study)

Tiihonen J, on behalf of all authors. 2009. The Lancet

Cardiac repolarization and striatal dopamine transporter function are interrelated

Kauppila E, Vanninen E, Kuusela T, Kaurijoki S, Karhunen L, Pietiläinen KH, Rissanen A, Kaprio J, Tiihonen J, Kuikka J, Kaurijoki S, Karhunen L. 2009. Nuclear medicine communications. 30: 713-717

Dopamine D2/3 receptor binding potential and occupancy in midbrain and temporal cortex by haloperidol, olanzapine and clozapine

Tuppurainen H, Kuikka JT, Viinamäki H, Husso M, Tiihonen J. 2009. Psychiatry and clinical neurosciences. 63: 529-537

Effects of MAOA-genotype, alcohol consumption, and aging on violent behavior

Tikkanen R, Sjöberg RL, Ducci F, Goldman D, Holi M, Tiihonen J, Virkkunen M. 2009. Alcoholism-clinical and experimental research. 33: 428-434

Low non-oxidative glucose metabolism and violent offending: An 8-year prospective follow-up study

Virkkunen M, Rissanen A, Franssila-Kallunki A, Tiihonen J. 2009. Psychiatry research. 168: 26-31

Predicting forensic admission among the mentally ill in a multinational setting: A Bayesian modelling approach

Soini EJO, Rissanen T, Tiihonen J, Hodgins S, Eronen M, Ryynänen O-P. 2009. Data and knowledge engineering. 68: 1427-1440

Premorbid personality factors in schizophrenia and bipolar disorder: Results from a large cohort study of male conscripts

Lönnqvist J-E, Verkasalo M, Haukka J, Nyman K, Tiihonen J, Laaksonen I, Leskinen J, Lönnqvist J, Henriksson M. 2009. Journal of abnormal psychology. 118: 418-423

Psykopatian etiologia

Repo-Tiihonen E, Holi M, Tiihonen J. Teoksessa: Häkkänen-Nyholm H(toim.) , 2009. Psykopatia. s. 99-111. Edita Prima

Recidivistic offending and mortality in alcoholic violent offenders: A prospective follow-up study

Tikkanen R, Holi M, Lindberg N, Tiihonen J, Virkkunen M. 2009. Psychiatry research. 168: 18-25

The efficacy of lamotrigine in clozapine-resistant schizophrenia: A systemic review and meta-analysis

Tiihonen J, Wahlbeck K, Kiviniemi V. 2009. Schizophrenia research. 109: 10-14

Association between medication and risk of suicide, attempted suicide and death in nationwide cohort of suicidal patients with schizophrenia

Haukka J, Tiihonen J, Härkänen T, Lönnqvist J. 2008. Pharmacoepidemiology and drug safety. 17: 686-696

Association of serotonin transporter promoter regulatory region polymorphism and cerebral activity to visual presentation of food

Kaurijoki S, Kuikka JT, Niskanen E, Carlson S, Pietiläinen KH, Pesonen U, Kaprio JM, Rissanen A, Tiihonen J, Karhunen L, Karhunen L. 2008. Clinical physiology and functional imaging. 28: 270-276

Autoradiographic characterization of alpha 2C-adrenoceptors in the human striatum

Fagerholm V, Rokka J, Nyman L, Sallinen J, Tiihonen J, Tupala E, Haaparanta M, Hietala J. 2008. Synapse. 62: 508-515

Brain anatomy of persistent violent offenders: more rather than less

Tiihonen J, Rossi R, Laakso MP, Hodgins S, Testa C, Perez J, Repo-Tiihonen E, Vaurio O, Soininen H, Aronen HJ, Könönen M, Thompson PM, Frisoni G, Könönen M, Soininen H. 2008. Psychiatry research: neuroimaging. 163: 201-212

Changes in midbrain serotonin transporter availability in atypically depressed subjects after one year of psychotherapy

Lehto SM, Tolmunen T, Joensuu M, Saarinen PI, Valkonen-Korhonen M, Vanninen R, Ahola P, Tiihonen J, Kuikka J, Lehtonen J. 2008. Progress in neuro-psychopharmacology and biological psychiatry. 32: 229-237

Characterization of metabolic syndrome among forensic psychiatric inpatients

Ojala K, Niskanen L, Tiihonen J, Paavola P, Putkonen A, Repo-Tiihonen E. 2008. Journal of forensic psychiatry and psychology. 19: 33-51

Correlation between the SERT binding densities in hypothalamus and amygdala in Cloninger type 1 and 2 alcoholics

Storvik M, Haukijärvi T, Tupala E, Tiihonen J. 2008. Alcohol and alcoholism. 43: 25-30

Cortical dopamine D1 receptors in type 1 and type 2 alcoholics measured with human whole hemisphere autoradiography

Tupala E, Tiihonen J. 2008. Psychiatry research: neuroimaging. 162: 1-9

Midbrain serotonin and striatum dopamine transporter binding in double depression: a one-year follow-up study

Lehto SM, Tolmunen T, Kuikka J, Valkonen -Korhonen M, Joensuu M, Saarinen PI, Vanninen R, Ahola P, Tiihonen J, Lehtonen J. 2008. Neuroscience letters. 441: 291-295

Pharmacotherapy of methamphetamine addiction: an update

Elkashef A, Vocci F, Hanson G, White J, Wickes W, Tiihonen J. 2008. Substance abuse. 29: 31-49

Statins are effective in treating dyslipidemia among psychiatric patiens using second-generation antipsychotic agents

Ojala K, Repo-Tiihonen E, Tiihonen J, Niskanen L. 2008. Journal of psychopharmacology. 22: 33-38

Striatal dopaminergic terminals in type 1 and type 2 alcoholics measured with [3H]dihydrotetrabenazine and human whole himisphere autoradiography

Tupala E, Häkkinen M, Storvik M, Tiihonen J. 2008. Psychiatry research: neuroimaging. 163: 70-75

Temporal cortex dopamine D2/3 receptor binding in major depression

Lehto S, Kuikka J, Tolmunen T, Hintikka J, Viinamäki H, Vanninen R, Haatainen K, Koivumaa-Honkanen H, Honkalampi K, Tiihonen J. 2008. Psychiatry and clinical neurosciences. 62: 345-348

Vagushermostimulaattori hoitoresistentin depression hoidossa

Kaila M, Lehtonen M-L, Kärkkäinen M, Tiihonen J. 2008. Lääkärilehti. 63: 271-273

A comparison of aripiprazole, methylphenidate, and placebo for amphetamine dependence

Tiihonen J, Kuoppasalmi K, Föhr J, Tuomola P, Kuikanmäki O, Vorma H, Sokero P, Haukka J, Meririnne E. 2007. American journal of psychiatry. 164: 160-162

A comparison of general adult and forensic patients with schizophrenia living in the community

Hodgins S, Müller-Isberner R, Tiihonen J, Repo-Tiihonen E, Eronen M, Eaves D, Hart S, Webster C, Levander S, Tuninger E, Ross D, Kronstrand R. 2007. International journal of forensic mental health. 6: 65-77

A multisite study of community treatment programs for mentally ill offenders with major mental disorders. Design, measures, and the forensic sample

Hodgins S, Tengström A, Eriksson A, Österman R, Kronstrand R, Eavek D, Hart S, Webster C, Ross D, Levin A, Levander S, Tuninger E, Müller-Isberner R, Freese R, Tiihonen J, Kotilainen I, Repo-Tiihonen E, Väänänen K, Eronen M, Vokkolainen A. 2007. Criminal justice and behavior. 34: 211-228

Amygdala serotonin transporters in alcoholics measured by whole hemisphere autoradiography

Storvik M, Tiihonen J, Haukijärvi T, Tupala E. 2007. Synapse. 61: 629-636

Body size and violent offending among males in the Northern Finland 1966 birth cohort

Ikäheimo P, Räsänen P, Hakko H, Hartikainen A-L, Laitinen J, Hodgins S, Tiihonen J. 2007. Social psychiatry and psychiatric epidemiology. 42: 845-850

Energy substrate metabolism among habitually violent alcoholic offenders having antisocial personality disorder

Virkkunen M, Rissanen A, Naukkarinen H, Franssila-Kallunki A, Linnoila M, Tiihonen J. 2007. Psychiatry research. 150: 287-295

Functional COMT Val158Met polymorphism, risk of acute coronary events and serum homocysteine: the Kuopio Ischaemic Heart Disease Risk Factor Study

Voutilainen S, Tuomainen TP, Korhonen M, Mursu J, Virtanen JK, Happonen P, Alftan G, Erlund I, North KE, Mosher MJ, Kauhanen J, Tiihonen J, Kaplan GA, Salonen JT. 2007. PLoS ONE. 2: e181

Masennuslääkkeet ja itsetuhokäyttäytyminen

Tiihonen J. 2007. Lääkärilehti

Näkyykö pahuus aivoista?

Tiihonen J. 2007. Duodecim. 123: 2367-2368

Oikeuspsykiatria

Tiihonen J. Teoksessa: Lönnqvist J, Heikkinen M, Henriksson M, Marttunen M, Partonen T(toim.) , 2007. Psykiatria. 5. uud. p.. s. 650-667. Duodecim

Reduced midbrain serotonin transporter availability in drug-naive patients with depression measured by SERT-specific [(123)I] nor-beta-CIT SPECT imaging

Joensuu M, Tolmunen T, Saarinen PI, Tiihonen J, Kuikka J, Ahola P, Vanninen R, Lehtonen J. 2007. Psychiatry research: neuroimaging. 154: 125-131

Transmission of violent offending and crime across three generations

Putkonen A, Ryynänen O-P, Eronen M, Tiihonen J. 2007. Social psychiatry and psychiatric epidemiology. 42: 94-9

Violent persons with schizophrenia and comorbid disorders: a functional magnetic resonance imaging study

Joyal CC, Putkonen A, Mancini-Marïe A, Hodgins S, Kononen M, Boulay L, Pihlajamaki M, Soininen H, Stip E, Tiihonen J, Aronen HJ, Könönen M. 2007. Schizophrenia research. 91: 97-102

Antidepressants and the risk of suicide, attempted suicide, and overall mortality in a nationwide cohort

Tiihonen J, Lönnqvist J, Wahlbeck K, Klaukka T, Tanskanen A, Haukka J. 2006. Archives of general psychiatry. 63: 1358-1367

Effectiveness of antipsychotic treatments in a nationwide cohort of patients in community care after first hospitalisation due to schizophrenia and schizoaffective disorder: observational follow-up study

Tiihonen J, Walhbeck K, Lönnqvist J, Klaukka T, Ioannidis JP, Volavka J, Haukka J. 2006. BMJ (INTERNATIONAL). 333: 224

Fatal agranulocytosis 4 years after discontinuation of clozapine

Tiihonen J. 2006. American journal of psychiatry

Lower serotonin transporter binding in caudate in alcoholics

Storvik M, Tiihonen J, Haukijärvi T, Tupala E. 2006. Synapse. 59: 144-151

Midbrain binding of (123I)nor-beta-CIT in atypical depression

Lehto S, Tolmunen T, Joensuu M, Saarinen PI, Vanninen R, Ahola P, Tiihonen J, Kuikka J, Lehtonen J. 2006. Progress in neuro-psychopharmacology and biological psychiatry. 30: 1251-1255

Midbrain dopamine D2/3 receptor binding in schizophrenia

Tuppurainen H, Kuikka JT, Laakso MP, Viinamäki H, Husso M, Tiihonen J, Laakso MP. 2006. European archives of psychiatry and clinical neuroscience. 256: 382-387

Visualization of the cortical dopamine transporter in type 1 and 2 alcoholics with human whole hemisphere autoradiography

Tupala E, Halonen P, Tiihonen J. 2006. European neuropsychopharmacology. 16: 552-560

An outcome of psychodynamic psychotherapy: a case study of the change in serotonin transporter binding and the activation of the dream screen

Saarinen PI, Lehtonen J, Joensuu M, Tolmunen T, Ahola P, Vanninen R, Kuikka J, Tiihonen J. 2005. American journal of psychotherapy. 59: 61-73

Effects of venlafaxine treatment on clozapine plasma levels in schizophrenic patients

Repo-Tiihonen E, Eloranta A, Hallikainen T, Tiihonen J. 2005. Neuropsychobiology. 51: 173-176

Glutamatergic drugs for schizophrenia: a systematic review and meta-analysis

Tuominen HJ, Tiihonen J, Wahlbeck K. 2005. Schizophrenia research. 72: 225-234

Premorbid intellectual functioning in bipolar disorder and schizophrenia: Results from a cohort study of male conscripts

Tiihonen J, Haukka J, Henriksson M, Cannon M, Kieseppä T, Laaksonen I, Sinivuo J, Lönnqvist J. 2005. American journal of psychiatry. 162: 1904-1910

Seasonal variations in [3H]citalopram platelet binding between healthy controls and violent offenders in Finland

Callaway J, Storvik M, Halonen P, Hakko H, Räsänen P, Tiihonen J. 2005. Human psychopharmacology: clinical and experimental. 20: 467-472

Striatal dopamine D1 receptors in type 1 and 2 alcoholics measured with human whole hemisphere autoradiography

Tupala E, Tiihonen J. 2005. Brain research. 1031: 20-29

The consequences of Conduct Disorder for males who develop schizophrenia: Associations with criminality, aggressive behavior, substance use, and psychiatric services

Hodgins S, Tiihonen J, Ross D. 2005. Schizophrenia research. 78: 323-335

Topiramate add-on in treatment-resistant schizophrenia: a randomized, double-blind, placebo-controlled, crossover trial

Tiihonen J, Halonen P, Wahlbeck K, Repo-Tiihonen E, Hyvärinen S, Eronen M, Putkonen H, Takala P, Mehtonen O-P, Puck M, Oksanen J, Koskelainen P, Joffe G, Aer J, Hallikainen T, Ryynänen O-P, Tupala E. 2005. Journal of clinical psychiatry. 66: 1012-1015

Verklighetstrogen utvärderande forskning med hjälp av nationella datariserade register

Tiihonen J. 2005. Finska läkaresällskapets handlingar. 165: 26-27

Visualisation of the cortical dopamine D3 receptors in alcoholics and controls with human whole-hemisphere autoradiography

Tupala E, Hall H, Tiihonen J. 2005. Psychopharmacology. 181: 412-413

123I-beta-CIT binding and recovery from depression. A six-month follow-up study

Laasonen-Balk T, Viinamäki H, Kuikka JT, Husso-Saastamoinen M, Lehtonen J, Tiihonen J. 2004. European archives of psychiatry and clinical neuroscience. 254: 152-155

A controlled study of tryptophan and cortisol in violent offenders

Soderstrom H, Blennow K, Forsman A, Liesivuori J, Pennanen S, Tiihonen J. 2004. Journal of neural transmission. 111: 1605-1610

Brain serotonin 1A receptor binding in bulimia nervosa

Tiihonen J, Keski-Rahkonen A, Löppönen M, Muhonen M, Kajander J, Allonen T, Någren K, Hietala J, Rissanen A. 2004. Biological psychiatry. 55: 871-873

Characteristics and circumstances of homicidal acts committed by offenders with schizophrenia

Joyal CC, Putkonen A, Paavola P, Tiihonen J. 2004. Psychological medicine. 34: 433-442

Comorbid personality disorders and substance use disorders of mentally I11 homide offenders: A structural clinical study on dual and triple diagnoses

Putkonen A, Kotilainen I, Joyal CC, Tiihonen J. 2004. Schizophrenia bulletin. 30: 59-72

Cortical dopamine D2 receptors in type 1 and 2 alcoholics measured with human whole hemisphere autoradiography

Tupala E, Hall H, Halonen P, Tiihonen J. 2004. Synapse. 54: 129-137

Distribution of 5-HT7 receptors in the human brain: a preliminary autoradiographic study using [3H]SB-269970

Varnäs K, Thomas DR, Tupala E, Tiihonen J, Hall H. 2004. Neuroscience letters. 367: 313-316

Dopamine and alcoholism: neurobiological basis of ethanol abuse

Tupala E, Tiihonen J. 2004. Progress in neuro-psychopharmacology and biological psychiatry. 28: 1221-1247

Elevated midbrain serotonin transporter availability in mixed mania : a case report

Tolmunen T, Joensuu M, Saarinen PI, Mussalo H, Ahola P, Vanninen R, Kuikka J, Tiihonen J, Lehtonen J. 2004. Bmc psychiatry. 4: [13 September 2004]

MRI volumetry of the vermis and cerebellar hemispheres in men with schizophrenia

Joyal CC, Pennanen C, Tiihonen E, Laakso MP, Tiihonen J, Aronen HJ, Laakso MP. 2004. Psychiatry research: neuroimaging. 131: 115-124

Miksi pakon käyttö vaihtelee niin paljon psykiatrisessa hoidossa?

Tiihonen J. 2004. Lääkärilehti

Omega-3-rasvahapot -uusi lisähoito masennukseen?

Tanskanen A, Tiihonen J. 2004. Duodecim

Reduced brain serotonin transporter binding in patients with panic disorder

Maron E, Kuikka JT, Shlik J, Vasar V, Vanninen E, Tiihonen J. 2004. Psychiatry research: neuroimaging. 132: 173-181

SPECT imaging of serotonin transporter binding in patients with generalized anxiety disorder

Maron E, Kuikka JT, Ulst K, Tiihonen J, Vasar V, Shlik J. 2004. European archives of psychiatry and clinical neuroscience. 254: 392-396

Stimulanttiriippuvuuden hoidot

Tiihonen J. 2004. Duodecim

Alcoholics show altered histaminergic neurotransmission in several cortical areas - preliminary report

Alakärppä K, Tupala E, Mantere T, Särkioja T, Räsänen P, Tarhanen J, Tiihonen J, Tuomisto L. 2003. INFLAMMATION RESEARCH. SUPPLEMENT. 52: 37-38

Different effect of age on dopamine transporters in the dorsal and ventral striatum of controls and alcoholics

Tupala E, Hall H, Bergström K, Mantere T, Räsänen P, Särkioja T, Hiltunen J, Tiihonen J. 2003. Synapse. 48: 205-211

Dopamine D2 receptors and transporters in type 1 and 2 alcoholics measured with human whole hemisphere autoradiography

Tupala E, Hall H, Bergström K, Mantere T, Räsänen P, Särkioja T, Tiihonen J. 2003. Human brain mapping. 20: 91-102

Dopamine receptors and transporters in the brain reward circuits of type 1 and 2 alcoholics measured with human whole hemisphere autoradiography

Tupala E, Hall H, Mantere T, Räsänen P, Särkioja T, Tiihonen J. 2003. Neuroimage. 19: 145-155

Ethanol consumption and DRD2 gene TaqI A polymorphism among socially drinking males

Hallikainen T, Hietala J, Kauhanen J, Pohjalainen T, Syvälahti E, Salonen JT, Tiihonen J. 2003. American journal of medical genetics. Part A. 119A: 152-155

Extrastriatal dopamine D2/3 receptor density and distribution in drug-naive schizophrenic patients

Tuppurainen H, Kuikka J, Viinamäki H, Husso-Saastamoinen M, Bergström K, Tiihonen J. 2003. Molecular psychiatry. 8: 453-455

Lamotrigine in treatment-resistant schizophrenia: a randomized placebo-controlled crossover trial

Tiihonen J, Hallikainen T, Ryynänen O-P, Repo-Tiihonen E, Kotilainen I, Eronen M, Toivonen P, Wahlbeck K, Putkonen A. 2003. Biological psychiatry. 54: 1241-1248

The amygdala and schizophrenia: A volumetric magnetic resonance imaging stury in first-episode, neuroleptic-naive patients

Joyal CC, Laakso MP, Tiihonen J, Syvälahti E, Vilkman H, Laakso A, Alakare B, Räkköläinen V, Salokangas RKR, Hietala J. 2003. Biological psychiatry. 54: 1302-1304

Total plasma L-tryptophan, free L-tryptophan and competing amino acid levels in a homicidal male adolescent with conduct disorder

Virkkunen M, Ebeling H, Moilanen I, Tani P, Pennanen S, Liesivuori J, Tiihonen J. 2003. Acta psychiatrica scandinavica. 108: 244-247

Treatment improves serotonin transporter binding and reduces binge eating

Tammela LI, Rissanen A, Kuikka JT, Karhunen LJ, Bergström KA, Repo-Tiihonen E, Naukkarinen H, Vanninen E, Tiihonen J, Uusitupa M. 2003. Psychopharmacology. 170: 89-93

A volumetric MRI study of the entorhinal cortex in first episode neuroleptic-naive schizophrenia

Joyal CC, Laakso MP, Tiihonen J, Syvälahti E, Vilkman H, Laakso A, Alakare B, Räkköläinen V, Salokangas RKR, Hietala J. 2002. Biological psychiatry. 51: 1005-1007

Analysis of monoamine oxidase A (MAOA) promoter polymorphism in Finnish male alcoholics

Saito T, Lachman HM, Diaz L, Hallikainen T, Kauhanen J, Salonen JT, Ryynanen O-P, Karvonen MK, Syvalahti E, Pohjalainen T, Hietala J, Tiihonen J. 2002. Psychiatry research. 109: 113-119

Effect of alcohol abuse on human brain histamine and tele-methylhistamine

Alakärppä K, Tupala E, Mantere T, Särkioja T, Räsänen P, Tarhanen J, Tiihonen J, Tuomisto L. 2002. INFLAMMATION RESEARCH. SUPPLEMENT. 51: 40-41

Is occupation relevant in suicide?

Koskinen O, Pukkila K, Hakko H, Tiihonen J, Väisänen E, Särkioja T, Räsänen P. 2002. Journal of affective disorders. 70: 197-203

Prefrontal volumes in habitually violent subjects with antisocial personality disorder and type 2 alcoholism

Laakso MP, Gunning-Dixon F, Vaurio O, Repo-Tiihonen E, Soininen H, Tiihonen J. 2002. Psychiatry research: neuroimaging. 114: 95-102

Seasonal variation in specific methods of suicide: a national register study of 20 234 Finnish people

Räsänen P, Hakko H, Jokelainen J, Tiihonen J. 2002. Journal of affective disorders. 71: 51-59

Seclusion treatment measures and serum cholesterol levels among Finnish male forensic psychiatric patients

Repo-Tiihonen E, Paavola P, Halonen P, Tiihonen J, Repo-Tiihonen E. 2002. JOURNAL OF FORENSIC PSYCHIATRY. 13: 157-165

Serotonin transporter distribution and density in the cerebral cortex of alcoholic and nonalcoholic comparison subjects: a whole-hemisphere autoradiography sudy

Mantere T, Tupala E, Hall H, Särkioja T, Räsänen P, Bergström K, Callaway J, Tiihonen J. 2002. American journal of psychiatry. 159: 599-606

Serum lipid levels and violence among Finnish male forensic psychiatric patients

Paavola P, Repo-Tiihonen E, Tiihonen J. 2002. JOURNAL OF FORENSIC PSYCHIATRY. 13: 555-568

The quantitative risk of violent crime and criminal offending: a case-control study among the offspring of recidivistic Finnish homicide offenders

Putkonen A, Ryynänen O-P, Eronen M, Tiihonen J. 2002. Acta psychiatrica scandinavica, supplement. 106: 54-57

Total serum cholesterol level, violent criminal offences, suicidal behavior, mortality and the appearance of conduct disorder in Finnish male criminal offenders with antisocial personality disorder

Repo-Tiihonen E, Halonen P, Tiihonen J, Virkkunen M. 2002. European archives of psychiatry and clinical neuroscience. 252: 8-11

Use of statistical techniques in studies of suicide seasonality, 1970 to 1997

Hakko H, Räsänen P, Tiihonen J, Nieminen P. 2002. Suicide and life-threatening behavior. 32: 191-208

A morphometric MRI study of the hippocampus in first-episode, neuroleptic-naive schizophrenia

Laakso MP, Tiihonen J, Syvälahti E, Vilkman H, Laakso A, Alakare B, Räkköläinen V, Salokangas RKR, Koivisto E, Hietala J. 2001. Schizophrenia research. 50: 3-7

Altered frontal lobe function suggested by source analysis of event-related potentials in impulsive violent alcoholics

Tarkka IM, Karhu J, Kuikka J, Pääkkönen A, Bergström K, Partanen J, Tiihonen J. 2001. Alcohol and alcoholism. 36: 323-328

Characterization of gamma-aminobutyrate type A receptors with atypical coupling between agonist and convulsant binding sites in discrete brain regions

Sinkkonen ST, Uusi-Oukari M, Tupala E, Särkioja T, Tiihonen J, Panula P, Lüddens H, Korpi ER. 2001. MOLECULAR BRAIN RESEARCH. 86: 168-178

Cluster C personality disorder has no independent effect on stratial dopamine transporter densities in major depression

Laasonen-Balk T, Viinamäki H, Kuikka J, Husso-Saastamoinen M, Lehtonen J, Halonen P, Tiihonen J. 2001. Psychopharmacology

Dopamine D2/D3-receptor and transporter densities in nucleus accumbens and amygdala of type 1 and 2 alcoholics

Tupala E, Hall H, Bergström K, Särkioja T, Räsänen P, Mantere T, Callaway J, Hiltunen J, Tiihonen J. 2001. Molecular psychiatry. 6: 261-267

Dopamine transporter density and novelty seeking among alcoholics

Laine TPJ, Ahonen A, Räsänen P, Tiihonen J. 2001. Journal of addictive diseases. 20: 91-96

Dopamine transporter in vitro binding and in vivo imaging in the brain

Bergström KA, Tupala E, Tiihonen J. 2001. Basic and clinical pharmacology and toxicology. 88: 287-293

Effects of ageing on serotonin transporters in healthy females

Kuikka JT, Tammela L, Bergström KA, Karhunen L, Uusitupa M, Tiihonen J. 2001. European journal of nuclear medicine and molecular imaging. 28: 911-913

Free L-tryptophan plasma levels in antisocial violent offenders

Tiihonen J, Virkkunen M, Räsänen P, Pennanen S, Sainio E-L, Callaway J, Halonen P, Liesivuori J. 2001. Psychopharmacology. 157: 395-400

Measurement of the striatal dopamine transporter density and heterogeneity in type 1 alcoholics using human whole hemisphere autoradiography

Tupala E, Kuikka JT, Hall H, Bergström K, Särkioja T, Räsänen P, Mantere T, Hiltunen J, Vepsäläinen J, Tiihonen J. 2001. Neuroimage. 14: 87-94

Mortality of antisocial male criminals

Repo-Tiihonen E, Virkkunen M, Tiihonen J. 2001. JOURNAL OF FORENSIC PSYCHIATRY. 12: 677-683

Oikeuspsykiatria

Tiihonen J. Teoksessa: Lönnqvist J, Heikkinen M, Henriksson M, Marttunen M, Partonen T(toim.) , 2001. Psykiatria. 2. uud. p.. s. 746-761. Duodecim

Psychopathy and the posterior hippocampus

Laakso MP, Vaurio O, Koivisto E, Savolainen L, Eronen M, Aronen HJ, Hakola P, Repo E, Soininen H, Tiihonen J. 2001. Behavioural brain research. 118: 187-193

Recidivistic violent behavior and axis I and axis II disorders

Tiihonen J. Teoksessa: Pinard G-F, Pagani L(toim.) , 2001. Clinical Assessment of Dangerousness: Empirical Contributions. s. 121-135. Cambridge University Press

Reduced serotonin transporter binding in binge eating women

Kuikka JT, Tammela L, Karhunen L, Rissanen A, Bergström KA, Naukkarinen H, Vanninen E, Karhu J, Lappalainen R, Repo-Tiihonen E, Tiihonen J, Uusitupa M. 2001. Psychopharmacology. 155: 310-314

SPECT and neuropsychological performance in severe depression treated with ECT

Mervaala E, Könönen M, Föhr J, Husso-Saastamoinen M, Valkonen-Korhonen M, Kuikka JT, Viinamäki H, Tammi A-K, Tiihonen J, Partanen J, Lehtonen J. 2001. Journal of affective disorders. 66: 47-58

The A1 allele of the D2 dopamine receptor gene is associated with high dopamine transporter density in detoxified alcoholics

Laine TPJ, Ahonen A, Räsänen P, Pohjalainen T, Tiihonen J, Hietala J. 2001. Alcohol and alcoholism. 36: 262-265

A volumetric MRI study of the hippocampus in type 1 and 2 alcoholism

Laakso MP, Vaurio O, Savolainen L, Repo E, Soininen H, Aronen HJ, Tiihonen J. 2000. Behavioural brain research. 109: 177-186

Aging and homicide rates

Paanila J, Eronen M, Hakola P, Tiihonen J. 2000. Journal of forensic sciences. 45: 390-391

Aivojen toiminnallinen kuvantaminen psykiatriassa

Karhu J, Kuikka J, Tiihonen J. 2000. Duodecim. 116: 409-415

Association between the functional polymorphism of catechol-0-methyltransferase gene and alcohol consumption among social drinkers

Kauhanen J, Hallikainen T, Tuomainen T-P, Koulu M, Karvonen MK, Salonen JT, Tiihonen J. 2000. Alcoholism-clinical and experimental research. 24: 135-139

Benzodiazepine receptor density in major depression

Laasonen-Balk T, Viinamäki H, Kuikka J, Lehtonen J, Husso-Saastamoinen M, Mervaala E, Partanen J, Tiihonen J. 2000. Nordic journal of psychiatry. 54: 361-363

CYP2A6 genotype and smoking

Tiihonen J, Pesonen U, Kauhanen J, Koulu M, Hallikainen T, Leskinen L, Salonen JT. 2000. Molecular psychiatry. 5: 347-348

Dopamine-transporter density in nucleus accumbens of type-1 alcoholics

Tupala E, Hall H, Särkioja T, Räsänen P, Tiihonen J. 2000. The Lancet. 355: 380

Ethanol modulates evoked dopamine release in mouse nucleus accumbens: dependence on social stress and dose

Yavich L, Tiihonen J. 2000. European journal of pharmacology. 401: 365-373

Forensic psychiatric organization in Finland

Eronen M, Repo E, Vartiainen H, Tiihonen J. 2000. International journal of law and psychiatry. 23: 541-546

In vivo voltammetry with removable carbon fibre electrodes in freely-moving mice: dopamine release during intracranial self-stimulation

Yavich L, Tiihonen J. 2000. Journal of neuroscience methods. 104: 55-63

Lack of association between the functional variant of the catechol-o-methyltransferase (COMT) gene and early-onset alcoholism associated with severe antisocial behavior

Hallikainen T, Lachman H, Saito T, Volavka J, Kauhanen J, Salonen JT, Ryynänen O-P, Koulu M, Karvonen MK, Pohjalainen T, Syvälahti E, Hietala J, Tiihonen J. 2000. American journal of medical genetics. Part A. 96: 348-352

Metabolism of (123I)epidepride may affect brain dopamine D2 receptor imaging with single-photon emission tomography

Bergström KA, Yu M, Kuikka JT, Åkerman KK, Hiltunen J, Lehtonen J, Halldin C, Tiihonen J. 2000. European journal of nuclear medicine and molecular imaging. 27: 206-208

Oikeuspsykiatria

Tiihonen J, Hakola P. Teoksessa: Penttilä A, Hirvonen J, Saukko P, Karhunen PJ(toim.) , 2000. Oikeuslääketiede. 1. p.. s. 315-334. Duodecim

Patterns of dopamine overflow in mouse nucleus accumbens during intracranial self-stimulation

Yavich L, Tiihonen J. 2000. Neuroscience letters. 293: 41-44

Pharmacological intervention for preventing violence among the mentally ill with secondary alcohol- and drug-use disorders

Tiihonen J, Swartz MS. Teoksessa: Hodgins S(toim.) , 2000. Violence among the Mentally Ill: Effective Treatments and Management Strategies. s. 171-191. Kluwer

Pharmacological treatments for personality disordered offenders

Tiihonen J. Teoksessa: Hodgins S, Müller-Isberner R(toim.) , 2000. Violence, Crime and Mentally Disordered Offenders: Concepts and Methods for Effective Treatment and Prevention. s. 177-192. John Wiley & Sons

Quantitative MRI of the hippocampus and amygdala in severe depression

Mervaala E, Föhr J, Könönen M, Valkonen-Korhonen M, Vainio P, Partanen K, Partanen J, Tiihonen J, Viinamäki H, Karjalainen A-K, Lehtonen J. 2000. Psychological medicine. 30: 117-125

Regional cerebral blood flow during exposure to food in obese binge eating women

Karhunen LJ, Vanninen EJ, Kuikka JT, Lappalainen RI, Tiihonen J, Uusitupa MIJ. 2000. Psychiatry research: neuroimaging. 99: 29-42

Specific binding and laterality of human extrastriatal dopamine D2/D3 receptors in late onset type 1 alcoholic patients

Kuikka JT, Repo E, Bergström KA, Tupala E, Tiihonen J. 2000. Neuroscience letters. 292: 57-59

Suicidal behavior in patients with schizophrenia is related to COMT polymorphism

Nolan KA, Volavka J, Czobor P, Cseh A, Lachman H, Saito T, Tiihonen J, Putkonen A, Hallikainen T, Kotilainen I, Räsänen P, Isohanni M, Järvelin M-R, Karvonen MK. 2000. Psychiatric genetics. 10: 117-124

Weather conditions and violent behavior

Tiihonen J, Callaway J, Storvik M, Räsänen P, Repo E, Hakko H, Väisänen E, Mantere T. Teoksessa: de Dear R, Kalma J, Oke T, Auliciems A(toim.) , 2000. Biometeorology and Urban Climatology at the Turn of the Millennium. Selected Papers from the Conference ICB-ICUC'99.. s. 155-156. World Meterological Organization

Altered parallel auditory processing in schizophrenia patients

Pekkonen E, Huotilainen M, Katila H, Karhu J, Näätänen R, Tiihonen J. 1999. Schizophrenia bulletin. 25: 601-607

Association between low activity serotonin transporter promoter genotype and early onset alcoholism with habitual impulsive violent behavior

Hallikainen T, Saito T, Lachman HM, Volavka J, Pohjalainen T, Ryynänen O-P, Kauhanen J, Syvälahti E, Hietala J, Tiihonen J. 1999. Molecular psychiatry. 4: 385-388

Association between the functional variant of the catechol-O-methyltransferase (COMT) gene and type 1 alcoholism

Tiihonen J, Hallikainen T, Lachman H, Saito T, Volavka J, Kauhanen J, Salonen JT, Ryynänen O-P, Koulu M, Karvonen MK, Pohjalainen T, Syvälahti E, Hietala J. 1999. Molecular psychiatry. 4: 286-289

Comparison of iodine-123 labelled nor-beta-CIT and beta-CIT as potential radioligands for serotonin transporter imaging

Kuikka JT, Bergström KA, Åkerman K, Tiihonen J. Teoksessa: Bergmann H, Köhn H, Sinzinger H(toim.) , 1999. Radioactive Isotopes in Clinical Medicine and Research XXIII. Proceedings of the 23rd International Badgastein Symposium. s. 25-30. Birkhäuser

Dopamine transporter and D2-receptor density in late-onset alcoholism

Repo E, Kuikka JT, Bergström KA, Karhu J, Hiltunen J, Tiihonen J. 1999. Psychopharmacology. 147: 314-318

Dopamine transporter availability and depressive symptoms during alcohol withdrawal

Laine TPJ, Ahonen A, Räsänen P, Tiihonen J. 1999. Psychiatry research: neuroimaging. 90: 153-157

First evaluation in humans of (123I)PE2I: a selective radioligand for visualization of the striatal dopamine transporter density

Bergström KA, Kuikka JT, Emond P, Hiltunen J, Halldin C, Guilloteau D, Mauclaire L, Yu M , Karhu J , Tupala E, Tiihonen J. Teoksessa: Bergmann H, Köhn H, Sinzinger H(toim.) , 1999. Radioactive Isotopes in Clinical Medicine and Research XXIII. Proceedings of the 23rd International Badgastein Symposium. s. 19-23. Birkhäuser

Iodine-123 labelled PE2I for dopamine transporter imaging: influence of age in healthy subjects

Kuikka JT, Tupala E, Bergström KA, Hiltunen J, Tiihonen J. 1999. European journal of nuclear medicine and molecular imaging. 26: 1486-1488

Letter to the editor (to Is a large body size during childhood a risk factor for later aggression?)

Räsänen P, Hakko H, Järvelin M-R, Tiihonen J. 1999. Archives of general psychiatry

Maternal smoking during pregnancy and risk of criminal behavior among adult male offspring in the Northern Finland 1966 birth cohort

Räsänen P, Hakko H, Isohanni M, Hodgins S, Järvelin M-R, Tiihonen J. 1999. American journal of psychiatry. 156: 857-862

Mortality among habitually violent offenders

Paanila J, Hakola P, Tiihonen J. 1999. Forensic science international. 100: 187-191

Oikeuspsykiatria

Tiihonen J. Teoksessa: Lönnqvist J, Heikkinen M, Henriksson M, Marttunen M, Partonen T(toim.) , 1999. Psykiatria. s. 712-731. Duodecim

Outcome of different types of long-term antidepressant treatments: a 3-year follow-up study of 14 182 patients

Räsänen P, Hakko H, Jokelainen J, Tiihonen J. 1999. Journal of affective disorders. 55: 67-71

Pindolol and major affective disorders: a three-year follow-up study of 30,485 patients

Räsänen P, Hakko H, Tiihonen J. 1999. Journal of clinical psychopharmacology. 19: 297-302

Reply (to Cosinor modelling of suicides in Finland)

Hakko H, Räsänen P, Tiihonen J. 1999. Acta psychiatrica scandinavica

Schizophrenia and seasonality of admissions: the Northern Finland 1966 birth cohort study

Räsänen P, Hakko H, Järvelin M-R, Isohanni M, Tiihonen J. 1999. Schizophrenia research

Serum testosterone levels, mental disorders and criminal behaviour

Räsänen P, Hakko H, Visuri S, Paanila J, Kapanen P, Suomela T, Tiihonen J. 1999. Acta psychiatrica scandinavica. 99: 348-352

Striatal dopamine transporter density in major depression

Laasonen-Balk T, Kuikka J, Viinamäki H, Husso-Saastamoinen M, Lehtonen J, Tiihonen J. 1999. Psychopharmacology. 144: 282-285

Transient syncope and ECG changes associated with the concurrent administration of clozapine and diazepam

Tupala E, Niskanen L, Tiihonen J. 1999. Journal of clinical psychiatry

Abnormal structure of human striatal dopamine re-uptake sites in habitually violent alcoholic offenders: a fractal analysis

Kuikka JT, Tiihonen J, Bergström KA, Karhu J, Räsänen P, Eronen M. 1998. Neuroscience letters. 253: 195-197

Change in monoamine transporter density related to clinical recovery: A case-control study

Viinamäki H, Kuikka J, Tiihonen J, Lehtonen J. 1998. Nordic journal of psychiatry. 52: 39-44

Fentanyl decreases beta-CIT binding to the dopamine transporter

Bergström KA, Jolkkonen J, Kuikka JT, Åkerman KK, Viinamäki H, Airaksinen O, Länsimies E, Tiihonen J. 1998. Synapse. 29: 413-415

Fractal analysis - a new approach in brain receptor imaging

Kuikka J, Tiihonen J. 1998. Annals of medicine. 30: 242-248

Helsingin yliopiston psykiatrian klinikan tutkimustoiminta vuosina 1994-1997

Virkkunen M, Tiihonen J. 1998. Sosiaalilääketieteellinen aikakauslehti. 35: 171-173

Imaging the structure of the striatum: a fractal approach to SPECT image interpretation

Kuikka JT, Yang J, Karhu J, Laitinen T, Tupala E, Hallikainen T, Tiihonen J. 1998. Physiological measurement. 19: 367-374

Increasing homicide rate in Finland accompanied by decreasing seasonality over the period 1957-95

Hakko H, Räsänen P, Tiihonen J. 1998. Social science and medicine. 47: 1695-1698

Iodine-123 labeled nor-beta-CIT as a potential tracer for serotonin transporter imaging in the human brain with single-photon emission tomography

Hiltunen J, Åkerman KK, Kuikka JT, Bergström KA, Halldin C, Nikula T, Räsänen P, Tiihonen J, Vauhkonen M, Karhu J, Kupila J, Länsimies E, Farde L. 1998. European journal of nuclear medicine and molecular imaging. 25: 19-23

Juvenile mortality, mental disturbances and criminality: a prospective study of the Northern Finland 1966 birth cohort

Räsänen P, Tiihonen J, Isohanni M, Moring J, Koiranen M. 1998. Acta psychiatrica scandinavica. 97: 5-9

Kuopion yliopiston oikeuspsykiatrian klinikan tutkimustoiminta vuosina 1994-1997

Tiihonen J. 1998. Sosiaalilääketieteellinen aikakauslehti. 35: 174-175

Mitä uutta neurofarmakologiasta?

Castrén E, Männistö PT, Tiihonen J. 1998. Duodecim. 114: 993-1001

Parental age gap and child sex ratio - fact or fiction?

Hakko H, Räsänen P, Järvelin M-R , Tiihonen J. 1998. International journal of epidemiology

Pharmacokinetics and dosimetry of iodine-123 labelled PE2I in humans, a radioligand for dopamine transporter imaging

Kuikka JT, Baulieu JL, Hiltunen J, Halldin C, Bergström KA, Farde L, Emond P, Chalon S, Yu M, Nikula T, Laitinen T, Karhu J, Tupala E, Hallikainen T, Kolehmainen V, Mauclaire L, Maziere B, Tiihonen J, Guilloteau D. 1998. European journal of nuclear medicine and molecular imaging. 25: 531-534

Reversal of cerebral asymmetry in schizophrenia measured with magnetoencephalography

Tiihonen J, Katila H, Pekkonen E, Jääskeläinen IP, Huotilainen M, Aronen HJ, Ilmoniemi RJ, Räsänen P, Virtanen J, Salli E, Karhu J. 1998. Schizophrenia research. 30: 209-219

SPET psykiatrisessa tutkimuksessa

Kuikka J, Bergström K, Tiihonen J. 1998. Lääkärilehti. 53: 2301-2307

Schizophrenia, alcohol abuse, and violent behavior: a 26-year followup study of an unselected birth cohort

Räsänen P, Tiihonen J, Isohanni M, Rantakallio P, Lehtonen J, Moring J. 1998. Schizophrenia bulletin. 24: 437-441

Seasonal variation in suicide occurrence in Finland

Hakko H, Räsänen P, Tiihonen J. 1998. Acta psychiatrica scandinavica. 98: 92-97

Secular trends in the rates and seasonality of violent and nonviolent suicide occurrence in Finland during 1980-95

Hakko H, Räsänen P, Tiihonen J. 1998. Journal of affective disorders. 50: 49-54

Striatal presynaptic dopamine function in type 1 alcoholics measured with positron emission tomography

Tiihonen J, Vilkman H, Räsänen P, Ryynänen O-P, Hakko H, Bergman J, Hämäläinen T, Laakso A, Haaparanta-Solin M, Solin O, Kuoppamäki M, Syvälahti E, Hietala J. 1998. Molecular psychiatry. 4: 156-161

The incidence and onset-age of hospitalized bipolar affective disorder in Finland

Räsänen P, Tiihonen J, Hakko H. 1998. Journal of affective disorders. 48: 63-68

The metabolism of iodine-123 labelled 3-(5-cyclopropyl-1,2,4-oxadiazo-3-yl)-7-iodo-5,6-dihydro-5-methyl-6-oxo-4H-imidazo(1,5-a) (1,4)benzodiazepine (NNC 13-8241) measured in human plasma is only minor

Åkerman KK, Bergström KA, Halldin C, Lötjönen S, Yu M, Nikula T, Hiltunen J, Foged C, Kuikka JT, Tiihonen J. 1998. Human psychopharmacology: clinical and experimental. 13: 177-182

Benzodiazepine receptor uptake in a patient with panic disorder after citalopram treatment

Tiihonen J, Lepola U, Kuikka J. 1997. NEUROPSYCHIATRY, NEUROPSYCHOLOGY, AND BEHAVIORAL NEUROLOGY

Cerebral benzodiazepine receptor binding and distribution in generalized anxiety disorder: a fractal analysis

Tiihonen J, Kuikka J, Räsänen P, Lepola U, Koponen H, Liuska A, Lehmusvaara A, Vainio P, Könönen M, Bergström K, Yu M, Kinnunen I, Åkerman K, Karhu J. 1997. Molecular psychiatry. 2: 463-471

Dopamine reuptake site densities in patients with social phobia

Tiihonen J, Kuikka J, Bergström K, Lepola U, Koponen H, Leinonen E. 1997. American journal of psychiatry. 154: 239-242

Fractal analysis of striatal dopamine re-uptake sites

Kuikka JT, Tiihonen J, Karhu J, Bergström KA, Räsänen P. 1997. European journal of nuclear medicine and molecular imaging. 24: 1085-1090

Major mental disorders and violent behaviour

Tiihonen J. Teoksessa: Edling C, Golding A(toim.) , 1997. Violence as a Public Health Issue. Proceedings of a Conference Organized by the Royal Society of Medicine and the Swedish Society of Medicine. s. 27-28. Royal Society of Medicine Press Limited

Mental disorders and homicide: Quantitative risk assessment

Tiihonen J, Eronen M. 1997. NORDISK RETTSMEDISIN. 3: 75-78

Psychiatric disorders and violent behavior

Eronen M, Tiihonen J, Hakola P. 1997. International journal of psychiatry in clinical practice. 1: 179-188

Seasonal variation in the occurrence of homicide in Finland

Tiihonen J, Räsänen P, Hakko H. 1997. American journal of psychiatry. 154: 1711-1714

Single-photon emission tomography imaging of monoamine transporters in impulsive violent behaviour

Tiihonen J, Kuikka JT, Bergström KA, Karhu J, Viinamäki H, Lehtonen J, Hallikainen T, Yang J, Hakola P. 1997. European journal of nuclear medicine and molecular imaging. 24: 1253-1260

Specific major mental disorders and criminality: a 26-year prospective study of the 1966 northern Finland birth cohort

Tiihonen J, Isohanni M, Räsänen P, Koiranen M, Moring J. 1997. American journal of psychiatry. 154: 840-845

Striatal and extrastriatal imaging of dopamine D2 receptors in the living human brain with (123I)epidepride single-photon emission tomography

Kuikka JT, Åkerman KK, Hiltunen J, Bergström KA, Räsänen P, Vanninen E, Halldin C, Tiihonen J. 1997. European journal of nuclear medicine and molecular imaging. 24: 483-487

Characterization of C-11 or I-123 labelled beta-CIT-FP and beta-CIT-FE metabolism measured in monkey and human plasma. Identification of two labelled metabilites with HPLC

Bergström KA, Halldin C, Lundkvist C, Swan C-G, Åkerman KK, Kuikka JT, Hiltunen J, Tiihonen J, Länsimies E, Neumeyer JL, Farde L. 1996. Human psychopharmacology: clinical and experimental. 11: 483-490

Citalopram in the treatment of alcoholism: a double-blind placebo-controlled study

Tiihonen J, Ryynänen O-P, Kauhanen J, Hakola HPA, Salaspuro M. 1996. Pharmacopsychiatry. 29: 27-29

Factors associated with homicide recidivism in a 13-year sample of homicide offenders in Finland

Eronen M, Hakola P, Tiihonen J. 1996. Psychiatric services. 47: 403-406

Forensic psychotherapy. Book review. Cordess C, Cox M, eds. Crime, Psychodynamics and the Offender Patient

Räsänen P, Tiihonen J. 1996. The Lancet

Initial human studies with single-photon emission tomography using iodine-123 labelled 3-(5-cyclopropyl-1,2,4-oxadiazo-3-yl)-7 -iodo-5,6-dihydro-5-methyl-6-oxo-4H-imidazo(1,5-a)(1,4) -benzodiazepine (NNC 13-8241)

Kuikka JT, Hiltunen J, Foged C, Bergström KA, Halldin C, Åkerman K, Tiihonen J, Farde L. 1996. European journal of nuclear medicine and molecular imaging. 23: 798-803

Low incidence of mania in northern Finland

Veijola J, Räsänen P, Isohanni M, Tiihonen J. 1996. British journal of psychiatry

Mental disorders and homicidal behavior in Finland

Eronen M, Hakola P, Tiihonen J. 1996. Archives of general psychiatry. 53: 497-501

Naisten tekemät henkirikokset Suomessa 1980-94

Eronen M, Tiihonen J, Hakola P. 1996. Duodecim. 112: 1281-1286

Risk of homicidal behavior among discharged forensic psychiatric patients

Tiihonen J, Hakola P, Eronen M, Vartiainen H, Ryynänen O-P. 1996. Forensic science international. 79: 123-129

Schizophrenia and homicidal behavior

Eronen M, Tiihonen J, Hakola P. 1996. Schizophrenia bulletin. 22: 83-89

Serotonergic modulation of striatal D2 dopamine receptor binding in humans measured with positron emission tomography

Tiihonen J, Kuoppamäki M, Någren K, Bergman J, Eronen E, Syvälahti E, Hietala J. 1996. Psychopharmacology. 126: 277-280

Väkivaltainen potilas

Tiihonen J. Teoksessa: Isohanni M, Larivaara P, Winblad I(toim.) , 1996. Perusterveydenhuollon psykiatria 1. p.. s. 27-28. Duodecim

Acute ethanol-induced changes in cerebral blood flow

Kuikka J, Tiihonen J, Hakola P, Paanila J, Airaksinen J, Eronen M, Hallikainen T. Teoksessa: Bergmann H, Sinzinger H(toim.) , 1995. Radioactive Isotopes in Clinical Medicine and Research. s. 345-350. Birkhäuser

Altered cerebral blood flow during hysterical paresthesia

Tiihonen J, Kuikka J, Viinamäki H, Lehtonen J, Partanen J. 1995. Biological psychiatry. 37: 134-135

Altered striatal dopamine re-uptake site densities in habitually violent and non-violent alcoholics

Tiihonen J, Kuikka J, Bergström K, Hakola P, Karhu J, Ryynänen O-P, Föhr J. 1995. Nature medicine. 1: 654-657

Carbamazepine-induced changes in plasma levels of neuroleptics

Tiihonen J, Vartiainen H, Hakola P. 1995. Pharmacopsychiatry. 28: 26-28

Citalopram, a selective serotonin reuptake inhibitor, in the treatment of aggression in schizophrenia

Vartiainen H, Tiihonen J, Putkonen A, Koponen H, Virkkunen M, Hakola P, Lehto H. 1995. Acta psychiatrica scandinavica. 91: 348-351

Emootioiden neurofysiologiasta

Tiihonen J. Teoksessa: Lehtonen J, Viinamäki H, Väänänen K(toim.) , 1995. Psykiatrian vaellusvuodet. KYS:n psykiatrian klinikka 20 vuotta. s. 171-178.

Homicidal behaviour and mental disorders

Tiihonen J, Hakola P, Eronen M. 1995. British journal of psychiatry

Homicide and mental disorders

Tiihonen J, Hakola P. 1995. Psychiatria fennica. 26: 125-129

Imaging of serotonin and dopamine transporters in the living human brain

Kuikka JT, Tiihonen J, Bergström KA, Karhu J, Hartikainen P, Viinamäki H, Länsimies E, Lehtonen J, Hakola P. 1995. European journal of nuclear medicine and molecular imaging. 22: 346-350

Iodine-123 labelled N-(2-fluoroethyl)-2beta -carbomethoxy-3beta-(4-iodophenyl)nortropane for dopamine transporter imaging in the living human brain

Kuikka JT, Åkerman K, Bergström KA, Karhu J, Hiltunen J, Haukka J, Heikkinen J, Tiihonen J, Wang S, Neumeyer JL. 1995. European journal of nuclear medicine and molecular imaging. 22: 682-686

Lipophilic metabolite of [123I] beta-CIT in human plasma may obstruct quantitation of the dopamine transporter

Bergström KA, Halldin C, Kuikka JT, Swan C-G, Tiihonen J, Hiltunen J, Länsimies E, Farde L. 1995. Synapse. 19: 297-300

Pitfalls of SPECT studies of acute ethanol-induced changes in cerebral blood flow

Tiihonen J, Kuikka J. 1995. American journal of psychiatry

Quantitative risk assessment of homicidal behaviour

Tiihonen J. 1995. JOURNAL OF FORENSIC PSYCHIATRY. 6: 477-485

Risk of homicidal behaviour among persons convicted of homicide

Tiihonen J, Hakola P, Nevalainen A, Eronen M. 1995. Forensic science international. 72: 43-48

The metabolite pattern of (123I)beta CIT determined with a gradient HPLC method

Bergström KA, Halldin C, Kuikka JT, Swahn C-G, Tiihonen J, Hiltunen J, Länsimies E, Farde L. 1995. Nuclear medicine and biology. 22: 971-976

Uusi psykoosilääke risperidoni

Tiihonen J. 1995. Duodecim

Uusia löydöksiä skitsofreniaan liittyvistä neuroanatomisista muutoksista

Tiihonen J. 1995. SANDOZ REPORT. : 14-15

Uusimpia tutkimushavaintoja rikoksista syytettyjen henkilöiden oikeuspsykiatrisista mielentilatutkimuksista

Eronen M, Tiihonen J, Ylitapio J, Hakola P. 1995. Lakimies. : 538-547

Tutkimusryhmät

Avainsanat

An international research agenda for clozapine-resistant schizophrenia

Association of pharmacological treatments and real‐world outcomes in borderline personality disorder

Cause-specific excess mortality after first diagnosis of bipolar disorder: population-based cohort study

Cohort profile: SUPER-Finland – the Finnish study for hereditary mechanisms of psychotic disorders

Comparative Effectiveness of Pharmacotherapies for the Risk of Attempted or Completed Suicide Among Persons With Borderline Personality Disorder

Effects of Substance Use and Antisocial Personality on Neuroimaging-Based Machine Learning Prediction of Schizophrenia

Efficacy of immersive extended reality (XR) interventions on different symptom domains of schizophrenia spectrum disorders. A systematic review

Functional Characterization of Six SLCO1B1 (OATP1B1) Variants Observed in Finnish Individuals with a Psychotic Disorder

General and violent recidivism of former forensic psychiatric patients in Finland

Non-adherence to mood stabilizers and antipsychotics among persons with bipolar disorder-A nationwide cohort study

Real-world effectiveness of antidepressant use in persons with schizophrenia: within-individual study of 61,889 subjects

Real-world effectiveness of pharmacological treatments for bipolar disorder: Register-based national cohort study

Real-world use of pharmacological treatments for incident bipolar disorder: A Finnish nationwide cohort study

Safety of Antipsychotic Polypharmacy Versus Monotherapy in a Nationwide Cohort of 61,889 Patients With Schizophrenia

Substance Use and Sleep Problems in Patients With Psychotic Disorders

The use of long-acting injectables in early-phase schizophrenia

Use of antipsychotics and antidepressants in first‐episode psychotic depression: A nationwide register‐based study

Validation of the Collaborative Outcomes study on Health and Functioning during Infection Times (COH-FIT) questionnaire for adults

β2-Adrenoceptor Agonists in Asthma or Chronic Obstructive Pulmonary Disease and Risk of Parkinson’s Disease: Nested Case-Control Study

Aberrant motor contagion of emotions in psychopathy and high-functioning autism

Allopurinol, dipyridamole and calcium channel blockers in the treatment of bipolar disorder – A nationwide cohort study

Antipsychotic Use and Risk of Low-Energy Fractures in People With Schizophrenia: A Nationwide Nested Case-Control Study in Finland

Association of Pharmacological Treatments and Hospitalization and Death in Individuals With Amphetamine Use Disorders in a Swedish Nationwide Cohort of 13 965 Patients

Association of Treatment-Resistant Depression With Patient Outcomes and Health Care Resource Utilization in a Population-Wide Study

Associations between antipsychotic use, substance use and relapse risk in patients with schizophrenia: real-world evidence from two national cohorts

Brain structural alterations in autism and criminal psychopathy

Clinical and societal burden of incident major depressive disorder: A population‐wide cohort study in Stockholm

Clozapine and the risk of haematological malignancies – Authors' reply

Comparative effectiveness of mood stabilizers and antipsychotics in the prevention of hospitalization after lithium discontinuation in bipolar disorder

Courses of treatment and risk factors for treatment-resistant depression in Finnish primary and special healthcare: A nationwide cohort study

Differences in psychosocial functioning between psychotic disorders in the Finnish SUPER study

Effectiveness of Antipsychotic Use for Reducing Risk of Work Disability: Results From a Within-Subject Analysis of a Swedish National Cohort of 21,551 Patients With First-Episode Nonaffective Psychosis

Factors and their weight in reducing life expectancy in schizophrenia

Female Psychopathy and Mortality

Genome-wide association analyses of symptom severity among clozapine-treated patients with schizophrenia spectrum disorders

Half a century of research on antipsychotics and schizophrenia: A scientometric study of hotspots, nodes, bursts, and trends

Healthcare utilization, costs, and productivity losses in treatment-resistant depression in Finland – a matched cohort study

Implementation of CYP2D6 copy-number imputation panel and frequency of key pharmacogenetic variants in Finnish individuals with a psychotic disorder

Long-term treatment with clozapine and other antipsychotic drugs and the risk of haematological malignancies in people with schizophrenia: a nationwide case-control and cohort study in Finland

Lääkehoito voi vähentää psyykkisiin sairauksiin liittyvää ennenaikaista kuolleisuutta

Mortality in people with schizophrenia: a systematic review and meta‐analysis of relative risk and aggravating or attenuating factors

Mortality in psychotic depression: 18-year follow-up study

Mu-opioid receptor system modulates responses to vocal bonding and distress signals in humans

Optimal Doses of Specific Antipsychotics for Relapse Prevention in a Nationwide Cohort of Patients with Schizophrenia

Physical and mental health impact of COVID-19 on children, adolescents, and their families: The Collaborative Outcomes study on Health and Functioning during Infection Times - Children and Adolescents (COH-FIT-C&A)

Primary Nonadherence to Antipsychotic Treatment Among Persons with Schizophrenia

Prolaktiinipitoisuutta suurentavat psykoosilääkkeet ja rintasyöpäriski rekisteritiedon valossa

Psychosis and the Risk of Stranger Homicides

Psychotic depression and deaths due to suicide

Real-world effectiveness of antipsychotic doses for relapse prevention in patients with first-episode schizophrenia in Finland: a nationwide, register-based cohort study

Real-world effectiveness studies of low doses of antipsychotics – Authors' reply

Real‐world effectiveness of mood stabilizer use in schizophrenia

Real‐world effectiveness of pharmacological treatments of opioid use disorder in a national cohort

Representation and Outcomes of Individuals With Schizophrenia Seen in Everyday Practice Who Are Ineligible for Randomized Clinical Trials

Sleep in Psychotic Disorders: Results From Nationwide SUPER Finland Study

The collaborative outcomes study on health and functioning during infection times in adults (COH-FIT-Adults): Design and methods of an international online survey targeting physical and mental health effects of the COVID-19 pandemic

Twenty-year medication use trends in first-episode bipolar disorder

Vuoden 2022 Matti Äyräpään palkinnon saaja Jari Tiihonen: Lääkehoitojen vaikuttavuustutkimus vie kohti dataohjautuvaa terveydenhuoltoa

Women with Schizophrenia-Spectrum Disorders After Menopause: A Vulnerable Group for Relapse

Adenosine modulators and calcium channel blockers as add-on treatment for schizophrenia

Antipsychotic Polypharmacy for the Management of Schizophrenia: Evidence and Recommendations

Antipsychotic discontinuation: mind the patient and the real-world evidence

Antipsychotic use and risk of breast cancer in women with schizophrenia: a nationwide nested case-control study in Finland

Antipsychotics Use Is Associated With Greater Adherence to Cardiometabolic Medications in Patients With Schizophrenia: Results From a Nationwide, Within-subject Design Study

Associations of age, sex, sexual abuse, and genotype with monoamine oxidase a gene methylation

Brain Basis of Psychopathy in Criminal Offenders and General Population

Changes in the metabolic profile of human male postmortem frontal cortex and cerebrospinal fluid samples associated with heavy alcohol use

Clozapine, Long-Acting Injectables (and Polypharmacy?) Superior in U.S. and International Registries

Continuity of antipsychotic medication use among migrant and Finnish-born populations with a psychotic disorder: a register-based study

Contribution of astrocytes to familial risk and clinical manifestation of schizophrenia

Correspondence regarding De Girolamo et al., 2021 'A multinational case-control study comparing forensic and non-forensic patients with schizophrenia spectrum disorders: the EU-VIORMED project'

Effectiveness of pharmacotherapies for delusional disorder in a Swedish national cohort of 9076 patients

Exploring the relation between high-activity COMT Val158Met genotype and psychopathy in male offenders

HLA-DQB1 6672G>C (rs113332494) is associated with clozapine-induced neutropenia and agranulocytosis in individuals of European ancestry

Hip Fracture Risk in Antiepileptic Drug Initiators and Non-Initiators with Alzheimer's Disease

Incidence of schizophrenia and influence of prenatal and infant exposure to viral infectious diseases

Long-Term Real-World Effectiveness of Pharmacotherapies for Schizoaffective Disorder