Jenni Küblbeck

A toxicogenomic data space for system-level understanding and prediction of EDC-induced toxicity

Sakhteman, A; Failli, M; Kublbeck, J; Levonen, AL; Fortino, V. Environment international 156: 106751. 2021

Screening of SIRT6 inhibitors and activators: A novel activator has an impact on breast cancer cells

Tenhunen, Jonna; Kucera, Tomáš; Huovinen, Marjo; Küblbeck, Jenni; Bisenieks, Egils; Vigante, Brigita; Ogle, Zaiga; Duburs, Gunars; Doležal, Martin; Moaddel, Ruin; Lahtela-Kakkonen, Maija; Rahnasto-Rilla, Minna. Biomedicine and pharmacotherapy 138: 111452. 2021

Metabolism-Disrupting Chemicals and the Constitutive Androstane Receptor CAR

Küblbeck, Jenni; Niskanen, Jonna; Honkakoski, Paavo. Cells 9 10: 2306. 2020

The EDCMET project: Metabolic effects of endocrine disruptors

Küblbeck, Jenni; Vuorio, Taina; Niskanen, Jonna; Fortino, Vittorio; Braeunin, Albert; Abass, Khaled; Rautio, Arja; Hakkola, Jukka; Honkakoski, Paavo; Levonen, Anna-Liisa. International journal of molecular sciences 21 8: 3021. 2020

Effects of galloflavin and ellagic acid on sirtuin 6 and its anti-tumorigenic activities

Rahnasto-Rilla, Minna; Järvenpää, Joni; Huovinen, Marjo; Schroderus, Anna-Mari; Ihantola, Emmi-Leena; Küblbeck, Jenni; Khadeer, Mohammed; Moaddel, Ruin; Lahtela-Kakkonen, Maija. Biomedicine and pharmacotherapy 131: 110701. 2020

A Reverse Transfection Method for Screening of Nuclear Receptor Activators

Küblbeck, Jenni; Honkakoski, Paavo / Nuclear Receptors. 2019. 2019

DNA elements for constitutive androstane receptor- and pregnane X receptor-mediated regulation of bovine CYP3A28 gene

Giantin, M; Küblbeck, J; Zancanella, V; Prantner, V; Sansonetti, F; Schoeniger, A; Tolosi, R; Guerra, G; Da Ros, S; Dacasto, M; Honkakoski, P. PLoS ONE 14 3: e0214338. 2019

Metabolism of Scoparone in Experimental Animals and Humans

Juvonen, RO; Novák, F; Emmanouilidou, E; Auriola, S; Timonen, J; Heikkinen, AT; Küblbeck, J; Finel, M; Raunio, H. Planta medica 85 06: 453-464. 2019

Isoflavonien turvallisuus ja tutkimuksen haasteet

Küblbeck, Jenni; Huovinen, Marjo. Dosis 35 3: 274-289. 2019

The basis for strain-dependent rat aldehyde dehydrogenase 1A7 (ALDH1A7) gene expression

Touloupi, K; Kublbeck, J; Magklara, A; Molnar, F; Reinisalo, M; Konstandi, M; Honkakoski, P; Pappas, P. Molecular pharmacology 96 5: 655-663. 2019

Functional Characterization of a Novel Variant of the Constitutive Androstane Receptor (CAR, NR1I3)

Prantner, Viktoria; Cinnamon, Yuval; Küblbeck, Jenni; Molnár, Ferdin; Honkakoski, Paavo. Nuclear Receptor Research 5: 101386. 2018

Genetically Modified Caco-2 Cells With Improved Cytochrome P450 Metabolic Capacity

Küblbeck Jenni, Hakkarainen Jenni J, Petsalo Aleksanteri, Vellonen Kati-Sisko, Tolonen Ari, Reponen Petri, Forsberg Markus M, Honkakoski Paavo. JOURNAL OF PHARMACEUTICAL SCIENCES 105 2: 941-949. 2016

Regulation of Human Pluripotent Stem Cell-Derived Hepatic Cell Phenotype by Three-Dimensional Hydrogel Models

Toivonen Sanna, Malinen Melina M, Küblbeck Jenni, Petsalo Aleksanteri, Urtti Arto, Honkakoski Paavo, Otonkoski Timo. TISSUE ENGINEERING 22 13-14: 971-984. 2016

Regulation of bovine CYP3A28 promoter by pregnane X receptor (PXR) and constitutive androstane receptor (CAR)

Giantin M., Zancanella V., Kueblbeck J., Prantner V., Sansonetti F., Honkakoski P., Dacasto M.. 56-57. 2015

Improved assays for xenosensor activation based on reverse transfection

Küblbeck Jenni, Anttila Teemu, Pulkkinen Juha T, Honkakoski Paavo. TOXICOLOGY IN VITRO 29 7: 1759-1765. 2015

Characterization of ligand-dependent activation of bovine and pig constitutive androstane (CAR) and pregnane X receptors (PXR) with interspecies comparisons

Küblbeck Jenni, Zancanella Vanessa, Prantner Victoria, Molnár Ferdinand, Squires E. James, Dacasto Mauro, Honkakoski Paavo, Giantin Mery. XENOBIOTICA (LONDON) 46 (2016) 3: 200-210. 2015

Lääkeaineiden metaboliaa ja kuljetusta säätelevät tumareseptorit

Honkakoski Paavo, Molnár Ferdinand, Kublbeck Jenni. DOSIS : FARMASEUTTINEN AIKAKAUSKIRJA 30 3: 193. 2014

Direct and Rapid Transcript Analysis Assay for CYP mRNA Expression and Inducibility in Human Primary Hepatocytes

Mattinen Laura, Kublbeck Jenni, Rechardt Oona, Honkakoski Paavo, Rautio Jari. Drug Metabolism Letters 8 2: 77-87. 2014

Preclinical pharmacology of FL442, a novel nonsteroidal androgen receptor modulator

Poutiainen Pekka K, Huhtala Tuulia, Jääskeläinen Tiina, Petsalo Aleksanteri, Küblbeck Jenni, Kaikkonen Sanna, Palvimo Jorma J, Raunio Hannu, Närvänen Ale, Peräkylä Mikael, Juvonen Risto O, Honkakoski Paavo, Laatikainen Reino, Pulkkinen Juha T. MOLECULAR AND CELLULAR ENDOCRINOLOGY 387: 8-18. 2014

An update on the constitutive androstane receptor (CAR)

Molnár Ferdinand, Küblbeck Jenni, Jyrkkärinne Johanna, Prantner Viktória, Honkakoski Paavo. Drug Metabolism and Drug Interactions 28 2: 79-93. 2013

Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system

Pimkaew Prapapan, Küblbeck Jenni, Petsalo Aleksanteri, Jukka Jouni, Suksamrarn Apichart, Juvonen Risto, Auriola Seppo, Piyachaturawat Pawinee, Honkakoski Paavo. TOXICOLOGY IN VITRO 27 6: 2005-2012. 2013

Characterization of human cytochrome P450 induction by pesticides

Abass Khaled, Lämsä Virpi, Reponen Petri, Küblbeck Jenni, Honkakoski Paavo, Mattila Sampo, Pelkonen Olavi, Hakkola Jukka. TOXICOLOGY 294: 17-26. 2012

Molecular dynamics simulations for human CAR inverse agonists

Jyrkkärinne Johanna, Küblbeck Jenni, Pulkkinen Juha, Honkakoski Paavo, Laatikainen Reino, Poso Antti, Laitinen Tuomo. JOURNAL OF CHEMICAL INFORMATION AND MODELING 52: 457-464. 2012

Use of Xenosensors for Drug Metabolism Studies. Focus on Constitutive Androstane Receptor

Küblbeck Jenni. Publications of the University of Eastern Finland. Dissertations in Health Sciences 130. 2012

Towards personalized medicine with a three-dimensional micro-scale perfusion-based two-chamber tissue model system

Ma Liang, Barker Jeremy, Zhou Changchun, Li Wei, Zhang Jing, Lin Biaoyang, Foltz Gregory, Küblbeck Jenni, Honkakoski Paavo. BIOMATERIALS 33: 4353-4361. 2012

New in vitro tools to study human constitutive androstane receptor (CAR) biology: discovery and comparison of human CAR inverse agonists

Küblbeck Jenni, Jyrkkärinne Johanna, Molnár Ferdinand, Kuningas Tiina, Patel Jayendra, Windshügel Björn, Nevalainen Tapio, Laitinen Tuomo, Sippl Wolfgang, Poso Antti, Honkakoski Paavo. Molecular Pharmaceutics 8: 2424-2433. 2011

Use of comprehensive screening methods to detect selective human CAR activators

Küblbeck Jenni, Laitinen Tuomo, Jyrkkärinne Johanna, Rousu Timo, Tolonen Ari, Abel Tobias, Kortelainen Tanja, Uusitalo Jouko, Korjamo Timo, Honkakoski Paavo, Molnár Ferdinand. BIOCHEMICAL PHARMACOLOGY 82: 1994-2007. 2011

Up-regulation of CYP expression in hepatoma cells stably transfected by chimeric nuclear receptors

Küblbeck J, Reinisalo M, Mustonen R & Honkakoski P. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 40: 263-272. 2010

Insights into ligand-elicited activation of human constitutive androstane receptor based on novel agonists and three-dimensional quantitative structure-activity relationship

Jyrkkärinne J, Windshügel B, Rönkkö T, Tervo AJ, Küblbeck J, Lahtela-Kakkonen M, Sippl W, Poso A, Honkakoski P. JOURNAL OF MEDICINAL CHEMISTRY 51: 7181-7192. 2008

Discovery of substituted sulfonamides and thiazolidin-4-one derivatives as agonists of human constitutive androstane receptor

Küblbeck J, Jyrkkärinne J, Poso A, Turpeinen M, Sippl W, Honkakoski P, Windshügel B. BIOCHEMICAL PHARMACOLOGY 76: 1288-1297. 2008

Comparison of homology models and X-ray structures of the nuclear receptor CAR: Assessing the structural basis of constitutive activity

Windshügel B, Jyrkkärinne J, Vanamo J, Poso A, Honkakoski P, Sippl W. JOURNAL OF MOLECULAR GRAPHICS AND MODELLING 25: 644-657. 2007

Tutkimusryhmät

Projektit

Avainsanat

Julkaisut

A toxicogenomic data space for system-level understanding and prediction of EDC-induced toxicity

Screening of SIRT6 inhibitors and activators: A novel activator has an impact on breast cancer cells

Metabolism-Disrupting Chemicals and the Constitutive Androstane Receptor CAR

The EDCMET project: Metabolic effects of endocrine disruptors

Effects of galloflavin and ellagic acid on sirtuin 6 and its anti-tumorigenic activities

A Reverse Transfection Method for Screening of Nuclear Receptor Activators

DNA elements for constitutive androstane receptor- and pregnane X receptor-mediated regulation of bovine CYP3A28 gene

Metabolism of Scoparone in Experimental Animals and Humans

Isoflavonien turvallisuus ja tutkimuksen haasteet

The basis for strain-dependent rat aldehyde dehydrogenase 1A7 (ALDH1A7) gene expression

Functional Characterization of a Novel Variant of the Constitutive Androstane Receptor (CAR, NR1I3)

Genetically Modified Caco-2 Cells With Improved Cytochrome P450 Metabolic Capacity

Regulation of Human Pluripotent Stem Cell-Derived Hepatic Cell Phenotype by Three-Dimensional Hydrogel Models

Regulation of bovine CYP3A28 promoter by pregnane X receptor (PXR) and constitutive androstane receptor (CAR)

Improved assays for xenosensor activation based on reverse transfection

Characterization of ligand-dependent activation of bovine and pig constitutive androstane (CAR) and pregnane X receptors (PXR) with interspecies comparisons

Lääkeaineiden metaboliaa ja kuljetusta säätelevät tumareseptorit

Direct and Rapid Transcript Analysis Assay for CYP mRNA Expression and Inducibility in Human Primary Hepatocytes

Preclinical pharmacology of FL442, a novel nonsteroidal androgen receptor modulator

An update on the constitutive androstane receptor (CAR)

Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system

Characterization of human cytochrome P450 induction by pesticides

Molecular dynamics simulations for human CAR inverse agonists

Use of Xenosensors for Drug Metabolism Studies. Focus on Constitutive Androstane Receptor

Towards personalized medicine with a three-dimensional micro-scale perfusion-based two-chamber tissue model system

New in vitro tools to study human constitutive androstane receptor (CAR) biology: discovery and comparison of human CAR inverse agonists

Use of comprehensive screening methods to detect selective human CAR activators

Up-regulation of CYP expression in hepatoma cells stably transfected by chimeric nuclear receptors

Insights into ligand-elicited activation of human constitutive androstane receptor based on novel agonists and three-dimensional quantitative structure-activity relationship

Discovery of substituted sulfonamides and thiazolidin-4-one derivatives as agonists of human constitutive androstane receptor

Comparison of homology models and X-ray structures of the nuclear receptor CAR: Assessing the structural basis of constitutive activity