Jenni Küblbeck

The KEAP1-NRF2 pathway: Targets for therapy and role in cancer

Adinolfi, Simone; Patinen, Tommi; Jawahar Deen, Ashik; Pitkänen, Sini; Härkönen, Jouni; Kansanen, Emilia; Küblbeck, Jenni; Levonen, Anna-Liisa. 2023. Redox biology. 63:

Gefitinib-Tamoxifen Hybrid Ligands as Potent Agents against Triple-Negative Breast Cancer

Abdelmalek, Carine M.; Hu, Zexi; Kronenberger, Thales; Küblbeck, Jenni; Kinnen, Franziska J.M.; Hesse, Salma S.; Malik, Afsin; Kudolo, Mark; Niess, Raimund; Gehringer, Matthias; Zender, Lars; Witt-Enderby, Paula A.; Zlotos, Darius P.; Laufer, Stefan A.. 2022. Journal of medicinal chemistry. 65: 4616-4632

Hormonihäirikköjä lautasella?

Küblbeck, Jenni; Pitkänen, Sini. 2022. Kehittyvä Elintarvike. 33: 16-17

Profiling the regulatory interplay of BET bromodomains and Sirtuins in cancer cell lines

Järvenpää, Joni; Rahnasto-Rilla, Minna; Lahtela-Kakkonen, Maija; Küblbeck, Jenni. 2022. Biomedicine and pharmacotherapy. 147:

A toxicogenomic data space for system-level understanding and prediction of EDC-induced toxicity

Sakhteman, A; Failli, M; Kublbeck, J; Levonen, AL; Fortino, V. 2021. Environment international. 156: 106751

Screening of SIRT6 inhibitors and activators: A novel activator has an impact on breast cancer cells

Tenhunen, Jonna; Kucera, Tomá¨; Huovinen, Marjo; Küblbeck, Jenni; Bisenieks, Egils; Vigante, Brigita; Ogle, Zaiga; Duburs, Gunars; Dole¸al, Martin; Moaddel, Ruin; Lahtela-Kakkonen, Maija; Rahnasto-Rilla, Minna. 2021. Biomedicine and pharmacotherapy. 138: 111452

Effects of galloflavin and ellagic acid on sirtuin 6 and its anti-tumorigenic activities

Rahnasto-Rilla, Minna; Järvenpää, Joni; Huovinen, Marjo; Schroderus, Anna-Mari; Ihantola, Emmi-Leena; Küblbeck, Jenni; Khadeer, Mohammed; Moaddel, Ruin; Lahtela-Kakkonen, Maija. 2020. Biomedicine and pharmacotherapy. 131: 110701

DNA elements for constitutive androstane receptor- and pregnane X receptor-mediated regulation of bovine CYP3A28 gene

Giantin, M; Küblbeck, J; Zancanella, V; Prantner, V; Sansonetti, F; Schoeniger, A; Tolosi, R; Guerra, G; Da Ros, S; Dacasto, M; Honkakoski, P. 2019. PLoS ONE. 14: e0214338

Isoflavonien turvallisuus ja tutkimuksen haasteet

Küblbeck, Jenni; Huovinen, Marjo. 2019. Dosis. 35: 274-289

Metabolism of Scoparone in Experimental Animals and Humans

Juvonen, RO; Novák, F; Emmanouilidou, E; Auriola, S; Timonen, J; Heikkinen, AT; Küblbeck, J; Finel, M; Raunio, H. 2019. Planta medica. 85: 453-464

The basis for strain-dependent rat aldehyde dehydrogenase 1A7 (ALDH1A7) gene expression

Touloupi, K; Kublbeck, J; Magklara, A; Molnar, F; Reinisalo, M; Konstandi, M; Honkakoski, P; Pappas, P. 2019. Molecular pharmacology. 96: 655-663

Functional Characterization of a Novel Variant of the Constitutive Androstane Receptor (CAR, NR1I3)

Prantner, Viktoria; Cinnamon, Yuval; Küblbeck, Jenni; Molnár, Ferdin; Honkakoski, Paavo. 2018. Nuclear Receptor Research. 5: 101386

Genetically Modified Caco-2 Cells With Improved Cytochrome P450 Metabolic Capacity

Küblbeck Jenni, Hakkarainen Jenni J, Petsalo Aleksanteri, Vellonen Kati-Sisko, Tolonen Ari, Reponen Petri, Forsberg Markus M, Honkakoski Paavo. 2016. Journal of pharmaceutical sciences. 105: 941-949

Regulation of Human Pluripotent Stem Cell-Derived Hepatic Cell Phenotype by Three-Dimensional Hydrogel Models

Toivonen Sanna, Malinen Melina M, Küblbeck Jenni, Petsalo Aleksanteri, Urtti Arto, Honkakoski Paavo, Otonkoski Timo. 2016. Tissue engineering. 22: 971-984

Characterization of ligand-dependent activation of bovine and pig constitutive androstane (CAR) and pregnane X receptors (PXR) with interspecies comparisons

Küblbeck Jenni, Zancanella Vanessa, Prantner Victoria, Molnár Ferdinand, Squires E. James, Dacasto Mauro, Honkakoski Paavo, Giantin Mery. 2015. Xenobiotica. 46 (2016): 200-210

Improved assays for xenosensor activation based on reverse transfection

Küblbeck Jenni, Anttila Teemu, Pulkkinen Juha T, Honkakoski Paavo. 2015. Toxicology in vitro. 29: 1759-1765

Regulation of bovine CYP3A28 promoter by pregnane X receptor (PXR) and constitutive androstane receptor (CAR)

Giantin M., Zancanella V., Kueblbeck J., Prantner V., Sansonetti F., Honkakoski P., Dacasto M.. 2015. Journal of veterinary pharmacology and therapeutics

Direct and Rapid Transcript Analysis Assay for CYP mRNA Expression and Inducibility in Human Primary Hepatocytes

Mattinen Laura, Kublbeck Jenni, Rechardt Oona, Honkakoski Paavo, Rautio Jari. 2014. Drug metabolism letters. 8: 77-87

Lääkeaineiden metaboliaa ja kuljetusta säätelevät tumareseptorit

Honkakoski Paavo, Molnár Ferdinand, Kublbeck Jenni. 2014. Dosis. 30: 193

Preclinical pharmacology of FL442, a novel nonsteroidal androgen receptor modulator

Poutiainen Pekka K, Huhtala Tuulia, Jääskeläinen Tiina, Petsalo Aleksanteri, Küblbeck Jenni, Kaikkonen Sanna, Palvimo Jorma J, Raunio Hannu, Närvänen Ale, Peräkylä Mikael, Juvonen Risto O, Honkakoski Paavo, Laatikainen Reino, Pulkkinen Juha T. 2014. Molecular and cellular endocrinology. 387: 8-18

An update on the constitutive androstane receptor (CAR)

Molnár Ferdinand, Küblbeck Jenni, Jyrkkärinne Johanna, Prantner Viktória, Honkakoski Paavo. 2013. Drug metabolism and drug interactions. 28: 79-93

Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system

Pimkaew Prapapan, Küblbeck Jenni, Petsalo Aleksanteri, Jukka Jouni, Suksamrarn Apichart, Juvonen Risto, Auriola Seppo, Piyachaturawat Pawinee, Honkakoski Paavo. 2013. Toxicology in vitro. 27: 2005-2012

Characterization of human cytochrome P450 induction by pesticides

Abass Khaled, Lämsä Virpi, Reponen Petri, Küblbeck Jenni, Honkakoski Paavo, Mattila Sampo, Pelkonen Olavi, Hakkola Jukka. 2012. Toxicology. 294: 17-26

Molecular dynamics simulations for human CAR inverse agonists

Jyrkkärinne Johanna, Küblbeck Jenni, Pulkkinen Juha, Honkakoski Paavo, Laatikainen Reino, Poso Antti, Laitinen Tuomo. 2012. Journal of chemical information and modeling. 52: 457-464

Towards personalized medicine with a three-dimensional micro-scale perfusion-based two-chamber tissue model system

Ma Liang, Barker Jeremy, Zhou Changchun, Li Wei, Zhang Jing, Lin Biaoyang, Foltz Gregory, Küblbeck Jenni, Honkakoski Paavo. 2012. Biomaterials. 33: 4353-4361

Use of Xenosensors for Drug Metabolism Studies. Focus on Constitutive Androstane Receptor

Küblbeck Jenni. 2012. Publications of the University of Eastern Finland. Dissertations in Health Sciences

New in vitro tools to study human constitutive androstane receptor (CAR) biology: discovery and comparison of human CAR inverse agonists

Küblbeck Jenni, Jyrkkärinne Johanna, Molnár Ferdinand, Kuningas Tiina, Patel Jayendra, Windshügel Björn, Nevalainen Tapio, Laitinen Tuomo, Sippl Wolfgang, Poso Antti, Honkakoski Paavo. 2011. Molecular pharmaceutics. 8: 2424-2433

Use of comprehensive screening methods to detect selective human CAR activators

Küblbeck Jenni, Laitinen Tuomo, Jyrkkärinne Johanna, Rousu Timo, Tolonen Ari, Abel Tobias, Kortelainen Tanja, Uusitalo Jouko, Korjamo Timo, Honkakoski Paavo, Molnár Ferdinand. 2011. Biochemical pharmacology. 82: 1994-2007

Up-regulation of CYP expression in hepatoma cells stably transfected by chimeric nuclear receptors

Küblbeck J, Reinisalo M, Mustonen R & Honkakoski P. 2010. European journal of pharmaceutical sciences. 40: 263-272

Discovery of substituted sulfonamides and thiazolidin-4-one derivatives as agonists of human constitutive androstane receptor

Küblbeck J, Jyrkkärinne J, Poso A, Turpeinen M, Sippl W, Honkakoski P, Windshügel B. 2008. Biochemical pharmacology. 76: 1288-1297

Insights into ligand-elicited activation of human constitutive androstane receptor based on novel agonists and three-dimensional quantitative structure-activity relationship

Jyrkkärinne J, Windshügel B, Rönkkö T, Tervo AJ, Küblbeck J, Lahtela-Kakkonen M, Sippl W, Poso A, Honkakoski P. 2008. Journal of medicinal chemistry. 51: 7181-7192

Comparison of homology models and X-ray structures of the nuclear receptor CAR: Assessing the structural basis of constitutive activity

Windshügel B, Jyrkkärinne J, Vanamo J, Poso A, Honkakoski P, Sippl W. 2007. Journal of molecular graphics and modelling. 25: 644-657

Tutkimusryhmät

Projektit

Avainsanat

Julkaisut

The KEAP1-NRF2 pathway: Targets for therapy and role in cancer

Gefitinib-Tamoxifen Hybrid Ligands as Potent Agents against Triple-Negative Breast Cancer

Hormonihäirikköjä lautasella?

Profiling the regulatory interplay of BET bromodomains and Sirtuins in cancer cell lines

A toxicogenomic data space for system-level understanding and prediction of EDC-induced toxicity

Screening of SIRT6 inhibitors and activators: A novel activator has an impact on breast cancer cells

Effects of galloflavin and ellagic acid on sirtuin 6 and its anti-tumorigenic activities

Metabolism-Disrupting Chemicals and the Constitutive Androstane Receptor CAR

The EDCMET project: Metabolic effects of endocrine disruptors

A Reverse Transfection Method for Screening of Nuclear Receptor Activators

DNA elements for constitutive androstane receptor- and pregnane X receptor-mediated regulation of bovine CYP3A28 gene

Isoflavonien turvallisuus ja tutkimuksen haasteet

Metabolism of Scoparone in Experimental Animals and Humans

The basis for strain-dependent rat aldehyde dehydrogenase 1A7 (ALDH1A7) gene expression

Functional Characterization of a Novel Variant of the Constitutive Androstane Receptor (CAR, NR1I3)

Genetically Modified Caco-2 Cells With Improved Cytochrome P450 Metabolic Capacity

Regulation of Human Pluripotent Stem Cell-Derived Hepatic Cell Phenotype by Three-Dimensional Hydrogel Models

Characterization of ligand-dependent activation of bovine and pig constitutive androstane (CAR) and pregnane X receptors (PXR) with interspecies comparisons

Improved assays for xenosensor activation based on reverse transfection

Regulation of bovine CYP3A28 promoter by pregnane X receptor (PXR) and constitutive androstane receptor (CAR)

Direct and Rapid Transcript Analysis Assay for CYP mRNA Expression and Inducibility in Human Primary Hepatocytes

Lääkeaineiden metaboliaa ja kuljetusta säätelevät tumareseptorit

Preclinical pharmacology of FL442, a novel nonsteroidal androgen receptor modulator

An update on the constitutive androstane receptor (CAR)

Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system

Characterization of human cytochrome P450 induction by pesticides

Molecular dynamics simulations for human CAR inverse agonists

Towards personalized medicine with a three-dimensional micro-scale perfusion-based two-chamber tissue model system

Use of Xenosensors for Drug Metabolism Studies. Focus on Constitutive Androstane Receptor

New in vitro tools to study human constitutive androstane receptor (CAR) biology: discovery and comparison of human CAR inverse agonists

Use of comprehensive screening methods to detect selective human CAR activators

Up-regulation of CYP expression in hepatoma cells stably transfected by chimeric nuclear receptors

Discovery of substituted sulfonamides and thiazolidin-4-one derivatives as agonists of human constitutive androstane receptor

Insights into ligand-elicited activation of human constitutive androstane receptor based on novel agonists and three-dimensional quantitative structure-activity relationship

Comparison of homology models and X-ray structures of the nuclear receptor CAR: Assessing the structural basis of constitutive activity