Juha Töyräs

Gamma Power of Electroencephalogram Arousal is Modulated by Respiratory Event Type and Severity in Obstructive Sleep Apnea

Pitkanen, Henna; Duce, Brett; Leppanen, Timo; Kainulainen, Samu; Kulkas, Antti; Myllymaa, Sami; Töyräs, Juha; Korkalainen, Henri. IEEE transactions on biomedical engineering [Epub ahead of print]: -. 2022

Quantitative dual contrast photon-counting computed tomography for assessment of articular cartilage health

Paakkari, Petri; Inkinen, Satu I; Honkanen, Miitu KM; Prakash, Mithilesh; Shaikh, Rubina; Nieminen, Miika T; Grinstaff, Mark W; Mäkelä, Janne TA; Töyräs, Juha; Honkanen, Juuso TJ. Scientific reports 11 1: 5556. 2021

Characterization of connective tissues using near-infrared spectroscopy and imaging

Afara, Isaac O; Shaikh, Rubina; Nippolainen, Ervin; Querido, William; Torniainen, Jari; Sarin, Jaakko K; Kandel, Shital; Pleshko, Nancy; Töyräs, Juha. Nature protocols 16 2: 1297-1329. 2021

Infrared Fiber-Optic Spectroscopy Detects Bovine Articular Cartilage Degeneration

Virtanen, Vesa; Nippolainen, Ervin; Shaikh, Rubina; Afara, Isaac O; Töyräs, Juha; Solheim, Johanne; Tafintseva, Valeria; Zimmermann, Boris; Kohler, Achim; Saarakkala, Simo; Rieppo, Lassi. Cartilage 13 Suppl 2: 285S-294S. 2021

The effect of subchondral bone plate thickness and trabecular bone volume fraction on the mechanical behavior of cartilage in post-traumatic osteoarthritis

Orava, H; Tanska, P; Huang, L; Ojanen, SP; Mäkelä, JTA; Finnilä, MAJ; Saarakkala, S; Herzog, W; Korhonen, RK; Töyräs, J / ORS Abstracts. 2021. 2021

Raman spectroscopy is sensitive to biochemical changes related to various cartilage injuries

Shaikh, Rubina; Nippolainen, Ervin; Virtanen, Vesa; Torniainen, Jari; Rieppo, Lassi; Saarakkala, Simo; Afara, Isaac O; Töyräs, Juha. Journal of raman spectroscopy 52 4: 796-804. 2021

Dual-contrast computed tomography enables detection of equine posttraumatic osteoarthritis in vitro

Saukko, AEA; Sarin, JK; Nykänen, O; Nissi, MJ; Te Moller, NCR; Weinans, H; Mancini, IAD; Visser, J; Brommer, H; van Weeren, PR; Malda, J; Grinstaff, MW; Töyräs, J. Journal of orthopaedic research 2022; 40 3: 703-711. 2021

An In-Laboratory Comparison of FocusBand EEG Device and Textile Electrodes Against a Medical-Grade System and Wet Gel Electrodes

Rusanen, Matias; Myllymaa, Sami; Kalevo, Laura; Myllymaa, Katja; Töyräs, Juha; Leppanen, Timo; Kainulainen, Samu. IEEE access 9: 132580-132591. 2021

Technical Performance of Textile-Based Dry Forehead Electrodes Compared With Medical-Grade Overnight Home Sleep Recordings

Rusanen, Matias; Kainulainen, Samu; Korkalainen, Henri; Kalevo, Laura; Myllymaa, Katja; Leppanen, Timo; Toyras, Juha; Arnardottir, Erna Sif; Myllymaa, Sami. IEEE access 9: 157902 - 157915. 2021

Biomechanical, biochemical, and near infrared spectral data of bovine knee ligaments and patellar tendon

Ristaniemi, Aapo; Torniainen, Jari; Paakkonen, Tommi; Stenroth, Lauri; Finnilä, Mikko A.J.; Tanska, Petri; Töyräs, Juha; Korhonen, Rami K.. Data in brief 36: 106976. 2021

Structure, composition and fibril-reinforced poroviscoelastic properties of bovine knee ligaments and patellar tendon

Ristaniemi, Aapo; Regmi, Dristi; Mondal, Diponkor; Torniainen, Jari; Tanska, Petri; Stenroth, Lauri; Finnilä, Mikko AJ; Töyräs, Juha; Korhonen, Rami K. Journal of the royal society interface 18 174: 20200737. 2021

Total durations of respiratory events are modulated within REM and NREM sleep by sleeping position and obesity in OSA patients

Rissanen, M; Oksenberg, A; Töyräs, J; Myllymaa, S; Leppänen, T. Sleep medicine 81: 394-400. 2021

Machine learning augmented near-infrared spectroscopy: In vivo follow-up of cartilage defects

Sarin, Jaakko K; Te Moller, Nikae Cr; Mohammadi, Ali; Prakash, Mithilesh; Torniainen, Jari; Brommer, Harold; Nippolainen, Ervin; Shaikh, Rubina; Mäkelä, Janne Ta; Korhonen, Rami K; René van Weeren, P; Afara, Isaac O; Töyräs, Juha. Osteoarthritis and cartilage 29 3: 423-432. 2021

Functional and Structural Properties of Human Patellar Articular Cartilage in Osteoarthritis

Nissinen, Mikko T; Hänninen, Nina; Prakash, Mithilesh; Mäkelä, Janne TA; Nissi, Mikko J; Töyräs, Juha; Nieminen, Miika T. Korhonen, Rami K; Tanska, Petri. Journal of biomechanics 126: 110634. 2021

Longer and Deeper Desaturations Are Associated With the Worsening of Mild Sleep Apnea: The Sleep Heart Health Study

Karhu, Tuomas; Myllymaa, Sami; Nikkonen, Sami; Mazzotti, Diego R; Töyräs, Juha; Leppänen, Timo. Frontiers in neuroscience 15: 657126. 2021

Automatic Respiratory Event Scoring in Obstructive Sleep Apnea Using a Long Short-Term Memory Neural Network

Nikkonen, Sami; Korkalainen, Henri; Leino, Akseli; Myllymaa, Sami; Duce, Brett; Leppänen, Timo; Töyräs, Juha. IEEE journal of biomedical and health informatics 25 8: 2917-2927. 2021

Subject-specific biomechanical analysis to estimate locations susceptible to osteoarthritis - Finite element modeling and MRI follow-up of ACL reconstructed patients

Bolcos, Paul O; Mononen, Mika E; Roach, Koren E; Tanaka, Matthew S; Suomalainen, Juha-Sampo; Mikkonen, Santtu; Nissi, Mikko J; Töyräs, Juha; Link, Thomas M; Souza, Richard B; Majumdar, Sharmila; Ma, C Benjamin; Li, Xiaojuan; Korhonen, Rami K. Journal of orthopaedic research [ePub ahead of print 24 Nov 2021]: 1-12. 2021

Assessment of Obstructive Sleep Apnea-Related Sleep Fragmentation Utilizing Deep Learning-Based Sleep Staging from Photoplethysmography

Huttunen, R; Leppänen, T; Duce, B; Oksenberg, A; Myllymaa, S; Töyräs, J; Korkalainen, H. Sleep 44 10: zsab142. 2021

Auttaako teknologia uniongelmiin?

Kainulainen, S; Töyräs, J; Leppänen, T. Tekniikan maailma 17: 68-72. 2021

Diabetes and cardiovascular diseases are associated with the worsening of intermittent hypoxaemia

Karhu, T; Myllymaa, S; Nikkonen, S; Mazzotti, DR; Kulkas, A; Töyräs, J; Leppänen, T. Journal of sleep research 2022; 31 1: e13441. 2021

Articular cartilage optical properties in the near-infrared (NIR) spectral range vary with depth and tissue integrity

Khan, Bilour; Kafian-Attari, Iman; Nippolainen, Ervin; Shaikh, Rubina; Semenov, Dmitry; Hauta-Kasari, Markku; Töyräs, Juha; Afara, Isaac O.. Biomedical optics express 12 10: 6066-6080. 2021

Detailed assessment of sleep architecture with deep learning and shorter epoch-to-epoch duration reveals sleep fragmentation of patients with obstructive sleep apnea

Korkalainen, Henri; Leppänen, Timo; Duce, Brett; Kainulainen, Samu; Aakko, Juhani; Leino, Akseli; Kalevo, Laura; Afara, Isaac O; Myllymaa, Sami; Töyräs, Juha. IEEE journal of biomedical and health informatics 25 7: 2567-2574. 2021

Self-Applied Home Sleep Recordings: The Future of Sleep Medicine

Korkalainen, Henri; Nikkonen, Sami; Kainulainen, Samu; Dwivedi, Amit Krishna; Myllymaa, Sami; Leppänen, Timo; Töyräs, Juha. Sleep medicine clinics 16 4: 545-556. 2021

Neural network analysis of nocturnal SpO2 signal enables easy screening of sleep apnea in patients with acute cerebrovascular disease

Leino, Akseli; Nikkonen, Sami; Kainulainen, Samu; Korkalainen, Henri; Töyräs, Juha; Myllymaa, Sami; Leppänen, Timo; Ylä-Herttuala, Salla; Westeren-Punnonen, Susanna; Muraja-Murro, Anu; Jäkälä, Pekka; Mervaala, Esa; Myllymaa, Katja. Sleep medicine 79: 71-78. 2021

Beyond the apnea-hypopnea index: alternative diagnostic parameters and machine learning solutions for estimation of sleep apnea severity

Leppänen, Timo; Myllymaa, Sami; Kulkas, Antti; Töyräs, Juha. Sleep 44 9: 1 - 3. 2021

Discrete element and finite element methods provide similar estimations for hip joint contact mechanics during walking gait

Li, Mao; Venäläinen, Mikko S; Chandra, Shekhar S; Patel, Rushabh; Fripp, Jurgen; Engstrom, Craig; Korhonen, Rami K; Töyräs, Juha; Crozier, Stuart. Journal of biomechanics 115: 110163. 2020

Estimating daytime sleepiness with previous night EEG, EOG and EMG spectrograms in patients with suspected sleep apnea using a convolutional neural network

Nikkonen, Sami; Korkalainen, Henri; Kainulainen, Samu; Myllymaa, Sami; Leino, Akseli; Kalevo, Laura; Oksenberg, Arie; Leppänen, Timo; Töyräs, Juha. Sleep 43 12: zsaa106. 2020

Mid-infrared and Near infrared spectroscopic analysis of mechanically and enzymatically damaged cartilage

Nippolainen, Ervin; Shaikh, Rubina; Virtanen, Vesa; Rieppo, Lassi; Afara, Isaac; Saarakkala, Simo; Töyräs, Juha / Proceedings Biophotonics Congress: Optics in the Life Sciences Congress 2019. 2020. 2020

Mid-infrared spectroscopic assessment of cartilage degeneration

Shaikh, Rubina; Nippolainen, Ervin; Virtanen, Vesa; Rieppo, Lassi; Haas, Julian; Mizaikoff, Boris; Artyushenko, Viacheslav; Bibikova, Olga; Afara, Isaac; Saarakkala, Simo; Töyräs, Juha / Proceedings Biophotonics Congress: Optics in the Life Sciences Congress 2019. 2020. 2020

Rapid CT-based Estimation of Articular Cartilage Biomechanics in the Knee Joint Without Cartilage Segmentation

Mohammadi, Ali; Myller, Katariina A H; Tanska, Petri; Hirvasniemi, Jukka; Saarakkala, Simo; Töyräs, Juha; Korhonen, Rami K; Mononen, Mika E. Annals of biomedical engineering 48: 2965-2975. 2020

Clinical Contrast-enhanced Computed Tomography with Semiautomatic Segmentation Provides Feasible Input for Computational Models of the Knee Joint

Myller, KAH; Korhonen, R; Töyräs, J; Tanska, P; Väänänen, S; Jurvelin, JS; Saarakkala, S; Mononen, ME. Journal of biomechanical engineering: transactions of the ASME 142 5: 051001. 2020

Tailored Synthesis of PEGylated Bismuth Nanoparticles for X-ray Computed Tomography and Photothermal Therapy: One-Pot, Targeted Pyrolysis, and Self-Promotion

Xu, Wujun; Cui, Pang; Happonen, Emilia; Leppänen, Jukka; Liu, Lizhi; Rantanen, Jimi; Majda, Dorota; Saukko, Annina; Thapa, Rinez; Nissinen, Tuomo; Tynkkynen, Tuulia; Töyräs, Juha; Fan, Li; Liu, Wenchao; Lehto, Vesa-Pekka. Acs applied materials and interfaces 12 42: 47233-47244. 2020

Near Infrared Spectroscopy Enables Differentiation of Mechanically and Enzymatically Induced Cartilage Injuries

Nippolainen, Ervin; Shaikh, Rubina; Virtanen, Vesa; Rieppo, Lassi; Saarakkala, Simo; Töyräs, Juha; Afara, Isaac. Annals of biomedical engineering 48 9: 2343-2353. 2020

Bright ultra-short echo time SWIFT MRI signal at the osteochondral junction is not located in the calcified cartilage

Nykänen, Olli; Leskinen, Henri P P; Finnilä, Mikko; Karhula, Sakari S; Turunen, Mikael J; Töyräs, Juha; Saarakkala, Simo; Nissi, Mikko J. Journal of orthopaedic research 38 12: 2649-2656. 2020

Optical properties of articular cartilage in the near-infrared spectral range are related to its proteoglycan content

Kafian-Attari, Iman; Semenov, Dmitry; Nippolainen, Ervin; Hauta-Kasari, Markku; Töyräs, Juha; Afara, Isaac O / Proceedings Volume 11363, Tissue Optics and Photonics. 2020. 2020

Comparison of water, hydroxyproline, uronic acid and elastin contents of bovine knee ligaments and patellar tendon and their relationships with biomechanical properties

Ristaniemi, A; Torniainen, J; Stenroth, L; Finnilä, MAJ; Paakkonen, T; Töyräs, J; Korhonen, RK. Journal of the mechanical behavior of biomedical materials 104: 103639. 2020

Structural, compositional, and functional effects of blunt and sharp cartilage damage on the joint: a 9-month equine groove model study

Te Moller, Nikae CR; Mohammadi, Ali; Plomp, Saskia; Serra Bragança, Filipe M; Beukers, Martijn; Pouran, Behdad; Afara, Isaac O; Nippolainen, Ervin; Mäkelä, Janne TA; Korhonen, Rami K; Töyräs, Juha; Brommer, Harold; René van Weeren, P. Journal of orthopaedic research 2021; 39 11: 2363-2375. 2020

Open-source python module for automated preprocessing of near infrared spectroscopic data

Torniainen, J; Afara, IO; Prakash, M; Sarin, JK; Stenroth, L; Töyräs, J. Analytica chimica acta 1108: 1-9. 2020

Acute stroke and TIA patients have specific polygraphic features of obstructive sleep apnea

Leino, A; Westeren-Punnonen, S; Töyräs, J; Myllymaa, S; Leppänen, T; Ylä-Herttuala, S; Muraja-Murro, A; Kantanen, AM; Autere, J; Jäkälä, P; Mervaala, E; Myllymaa, K. Sleep and breathing 24 4: 1495-1505. 2020

Polysomnographic characteristics of severe obstructive sleep apnea vary significantly between hypertensive and normotensive patients of both genders

Leppänen, T; Kulkas, A; Töyräs, J; Myllymaa, S; Gadoth, N; Oksenberg, A. Sleep and breathing 2021; 25 1: 105-116. 2020

Quantification of Myocardial Blood Flow by Machine Learning Analysis of Modified Dual Bolus MRI Examination

Husso, Minna; Afara, Isaac O; Nissi, Mikko J; Kuivanen, Antti; Halonen, Paavo; Tarkia, Miikka; Teuho, Jarmo; Saunavaara, Virva; Vainio, Pauli; Sipola, Petri; Manninen, Hannu; Ylä-Herttuala, Seppo; Knuuti, Juhani; Töyräs, Juha. Annals of biomedical engineering 2021; 49: 653-662. 2020

Comparison of the effect of weight change, simulated computational continuous positive airway pressure treatment and positional therapy on severity of sleep apnea

Kulkas, Antti; Duce, Brett; Töyräs, Juha; Seppä, Juha; Leppänen, Timo. Journal of sleep research 2021; 30 2: e13070. 2020

Longer duration electroencephalogram arousals have a better relationship with impaired vigilance and health status in obstructive sleep apnoea

Duce, Brett; Kulkas, Antti; Töyräs, Juha; Terrill, Philip; Hukins, Craig. Sleep and breathing 2021; 25 1: 263-270. 2020

Machine Learning Classification of Articular Cartilage Integrity Using Near Infrared Spectroscopy

Afara, Isaac O; Sarin, Jaakko K; Ojanen, Simo; Finnilä, Mikko A J; Herzog, Walter; Saarakkala, Simo; Korhonen Rami K; Töyräs, Juha. Cellular and molecular bioengineering 13 3: 219-228. 2020

Near-Infrared Spectroscopy for Mapping of Human Meniscus Biochemical Constituents

Ala-Myllymäki, Juho; Paakkonen, Tommi; Joukainen, Antti; Kröger, Heikki; Lehenkari, Petri; Töyräs, Juha; Afara, Isaac O. Annals of biomedical engineering 2021; 49: 469-476. 2020

Automated Preprocessing of Near Infrared Spectroscopic Data

Torniainen, J; Afara, IO; Prakash, M; Sarin, JK; Stenroth, L; Töyräs, J / Bio-Optics: Design and Application 2019. 2020. 2020

Deep learning enables sleep staging from photoplethysmogram for patients with suspected sleep apnea

Korkalainen, H; Aakko, J; Duce, B; Kainulainen, S; Leino, A; Nikkonen, S; Afara, I O; Myllymaa, S; Töyräs, J; Leppänen, T. Sleep 43 11: zsaa098. 2020

Dual Contrast in Computed Tomography Allows Earlier Characterization of Articular Cartilage over Single Contrast

Bhattarai, Abhisek; Pouran, Behdad; Mäkelä, Janne T A; Shaikh, Rubina; Honkanen, Miitu K M; Prakash, Mithilesh; Kröger, Heikki; Grinstaff, Mark W; Weinans, Harrie; Jurvelin, Jukka S; Töyräs, Juha. Journal of orthopaedic research 38 10: 2230-2238. 2020

Identification of locations susceptible to osteoarthritis in patients with anterior cruciate ligament reconstruction: Combining knee joint computational modelling with follow-up T1p and T2 imaging

Bolcos, PO; Mononen, ME; Tanaka, MS; Yang, M; Suomalainen, JS; Nissi, MJ; Töyräs, J; Ma, B; Li, X; Korhonen, RK. Clinical biomechanics 79: 104844. 2020

Effects of Human Articular Cartilage Constituents on Simultaneous Diffusion of Cationic and Non-ionic Contrast Agents

Bhattarai, Abhisek; Mäkelä, Janne T A; Pouran, Behdad; Kröger, Heikki; Weinans, Harrie; Grinstaff, Mark W; Töyräs, Juha; Turunen, Mikael J. Journal of orthopaedic research 2021; 39 4: 771-779. 2020

Longer apneas and hypopneas are associated with greater ultra-short-term HRV in obstructive sleep apnea

Hietakoste, Salla; Korkalainen, Henri; Kainulainen, Samu; Sillanmäki, Saara; Nikkonen, Sami; Myllymaa, Sami; Duce, Brett; Töyräs, Juha; Leppänen, Timo. Scientific reports 10: 21556. 2020

Tissue optical properties combined with machine learning enables estimation of articular cartilage composition and functional integrity

Kafian-Attari, Iman; Nippolainen, Ervin; Semenov, Dmitry; Hauta-Kasari, Markku; Töyräs, Juha; Afara, Isaac O. Biomedical optics express 11 11: 6480-6494. 2020

Severe Desaturations Increase PVT-based Median Reaction Time and Number of Lapses in OSA Patients

Kainulainen, S; Duce, B; Korkalainen, H; Oksenberg, A; Leino, A; Arnardottir, E; Kulkas, A; Myllymaa, S; Töyräs, J; Leppänen, T. European respiratory journal 55: 1901849. 2020

Increased nocturnal arterial pulsation frequencies of obstructive sleep apnoea patients is associated with an increased number of lapses in a psychomotor vigilance task

Kainulainen, Samu; Duce, Brett; Korkalainen, Henri; Leino, Akseli; Huttunen, Riku; Kalevo, Laura; Arnardottir, Erna S; Kulkas, Antti; Myllymaa, Sami; Töyräs, Juha; Leppänen, Timo. ERJ open research 6 4: 00277-202. 2020

Power spectral densities of nocturnal pulse oximetry signals differ in OSA patients with and without daytime sleepiness

Kainulainen, Samu; Töyräs, Juha; Oksenberg, Arie; Korkalainen, Henri; Afara, Isaac O; Leino, Akseli; Kalevo, Laura; Nikkonen, Sami; Gadoth, Natan; Kulkas, Antti; Myllymaa, Sami; Leppänen, Timo. Sleep medicine 73: 231-237. 2020

Evaluation of articular cartilage with quantitative MRI in an equine model of post-traumatic osteoarthritis

Kajabi, Abdul Wahed; Casula, Victor; Sarin, Jaakko K; Ketola, Juuso H; Nykänen, Olli; Te Moller, Nikae C R; Mancini, Irina A D; Visser, Jetze; Brommer, Harold; René van Weeren, P; Malda, Jos; Töyräs, Juha; Nieminen, Miika T; Nissi, Mikko J. Journal of orthopaedic research 2021; 39 1: 63-73. 2020

Effect of sweating on electrode-skin contact impedances and artifacts in EEG recordings with various screen-printed Ag/Agcl electrodes

Kalevo, Laura; Miettinen, Tomi; Leino, Akseli; Kainulainen, Samu; Korkalainen, Henri; Myllymaa, Katja; Töyräs, Juha; Leppänen, Timo; Laitinen, Tiina; Myllymaa, Sami. IEEE access 8: 50934-50943. 2020

Prevalence and characteristics of positional obstructive sleep apnea (POSA) in patients with severe OSA

Oksenberg, A; Gadoth, N; Töyräs, J; Leppänen, T. Sleep and breathing 2020; 24 2: 551-559. 2019

Artificial neural network analysis of the oxygen saturation signal enables accurate diagnostics of sleep apnea

Nikkonen, S; Afara, IO; Leppänen, T; Töyräs, J. Scientific reports 9 1: 13200. 2019

Intra-night variation in apnea-hypopnea index affects diagnostics and prognostics of obstructive sleep apnea

Nikkonen, S; Töyräs, J; Mervaala, E; Myllymaa, S; Terrill, P; Leppänen, T. Sleep and breathing 2020; 24: 379-386. 2019

T2* and quantitative susceptibility mapping in an equine model of post-traumatic osteoarthritis: assessment of mechanical and structural properties of articular cartilage

Nykänen, O; Sarin, JK; Ketola, JH; Leskinen, H; te Moller, NCR; Tiitu, V; Mancini, IAD; Visser, J; Brommer, H; van Weeren, P René; Malda, J; Töyräs, J; Nissi, MJ. Osteoarthritis and cartilage 27 10: 1481-1490. 2019

Simultaneous Quantitation of Cationic and Non-ionic Contrast Agents in Articular Cartilage Using Synchrotron MicroCT Imaging

Saukko, AEA; Turunen, MJ; Honkanen, MKM; Lovric, G; Tiitu, V; Honkanen, JTJ; Grinstaff, MW; Jurvelin, JS; Töyräs, J. Scientific reports 9 1: 7118. 2019

Near infrared spectroscopy enables quantitative evaluation of human cartilage biomechanical properties during arthroscopy

Prakash, M; Joukainen, A; Torniainen, J; Honkanen, MKM; Rieppo, L; Afara, IO; Kröger, H; Töyräs, J; Sarin, JK. Osteoarthritis and cartilage 27 8: 1235-1243. 2019

Arthroscopic Determination of Cartilage Proteoglycan Content and Collagen Network Structure with Near-Infrared Spectroscopy

Sarin, JK; Nykänen, O; Tiitu, V; Mancini, IAD; Brommer, H; Visser, J; Malda, J; van Weeren, PR; Afara, IO; Töyräs, J. Annals of biomedical engineering 47 8: 1815-1826. 2019

Dataset on equine cartilage near infrared spectra, composition, and functional properties

Sarin, JK; Torniainen, J; Prakash, M; Rieppo, L; Afara, IO; Töyräs, J. Scientific data 6 1: 164. 2019

Polysomnographic scoring of sleep bruxism events is accurate even in the absence of video recording but unreliable with EMG-only setups

Miettinen, T; Myllymaa, K; Muraja-Murro, A; Westeren-Punnonen, S; Hukkanen, T; Töyräs, J; Lappalainen, R; Mervaala, E; Sipilä, K; Myllymaa, S. Sleep and breathing [First Online: 12 August 2019]: 1-12. 2019

Computational evaluation of altered biomechanics related to articular cartilage lesions observed in vivo

Myller, KAH; Korhonen, RK; Töyräs, J; Salo, J; Jurvelin, JS; Venäläinen, MS. Journal of orthopaedic research 37 5: 1042-1051. 2019

Does Magnetic Resonance Imaging Provide Superior Reliability for Achilles and Patellar Tendon Cross-Sectional Area Measurements Compared with Ultrasound Imaging?

Stenroth, Lauri; Sefa, Sandra; Arokoski, Jari; Töyräs, Juha. Ultrasound in medicine and biology 45 12: 3186-3198. 2019

Effects of body mass on microstructural features of the osteochondral unit: A comparative analysis of 37 mammalian species

Mancini, IAD; Rieppo, L; Pouran, B; Afara, IO; Braganca, FMS; van Rijen, MHP; Kik, M; Weinans, H; Toyras, J; van Weeren, PR; Malda, J. Bone 127: 664-673. 2019

Triple Contrast CT Method Enables Simultaneous Evaluation of Articular Cartilage Composition and Segmentation

Honkanen, MKM; Saukko, AEA; Turunen, MJ; Xu, W; Lovric, G; Honkanen, JTJ; Grinstaff, MW; Lehto, VP; Töyräs, J. Annals of biomedical engineering 2020; 48 2: 556-567. 2019

The hypoxic burden: also known as the desaturation severity parameter

Leppänen, Timo; Kulkas, Antti; Töyräs, Juha. European heart journal 40 35: 2991-2993. 2019

Imaging of Proteoglycan and Water Contents in Human Articular Cartilage with Full-Body CT Using Dual Contrast Technique

Honkanen, MKM; Matikka, H; Honkanen, JTJ; Bhattarai, A; Grinstaff, MW; Joukainen, A; Kröger, H; Jurvelin, JS; Töyräs, J. Journal of orthopaedic research 37 5: 1059-1070. 2019

Synchrotron microCT reveals the potential of the dual contrast technique for quantitative assessment of human articular cartilage composition

Honkanen, MKM; Saukko, AEA; Turunen, MJ; Shaikh, R; Prakash, M; Lovric, G; Joukainen, A; Kröger, H; Grinstaff, MW; Töyräs, J. Journal of orthopaedic research 2020; 38 3: 563-573. 2019

Contrast enhanced computed tomography for real-time quantification of glycosaminoglycans in cartilage tissue engineered constructs

Garcia, João P; Longoni, Alessia; Gawlitta, Debby; Rosenberg, Antoine J W P; Grinstaff, Mark W; Töyräs, Juha; Weinans, Harrie; Creemers, Laura B; Pouran, Behdad. Acta biomaterialia 100: 202-212. 2019

Quantification of porcine myocardial perfusion with modified dual bolus MRI - a prospective study with a PET reference

Husso, M; Nissi, MJ; Kuivanen, A; Halonen, P; Tarkia, M; Teuho, J; Saunavaara, V; Vainio, P; Sipola, P; Manninen, H; Ylä-Herttuala, S; Knuuti, J; Töyräs, J. Bmc medical imaging 19 1: 58. 2019

Severity of desaturations reflects OSA-related daytime sleepiness better than AHI

Kainulainen, S; Töyräs, J; Oksenberg, A; Korkalainen, H; Sefa, S; Kulkas, A; Leppänen, T. Journal of clinical sleep medicine 15 8: 1135-1142. 2019

Improved Sweat Artifact Tolerance of Screen-Printed EEG Electrodes by Material Selection-Comparison of Electrochemical Properties in Artificial Sweat

Kalevo, Laura; Miettinen, Tomi; Leino, Akseli; Kainulainen, Samu; Myllymaa, Katja; Toyras, Juha; Leppanen, Timo; Myllymaa, Sami. IEEE access 7: 133237-133247. 2019

Mortality-risk-based apnea-hypopnea index thresholds for diagnostics of obstructive sleep apnea

Korkalainen, H; Töyräs, J; Nikkonen, S; Leppänen, T. Journal of sleep research 28 6: e12855. 2019

Accurate Deep Learning-Based Sleep Staging in a Clinical Population with Suspected Obstructive Sleep Apnea

Korkalainen, Henri; Aakko, Juhani; Nikkonen, Sami; Kainulainen, Samu; Leino, Akseli; Duce, Brett; Afara, Isaac Oluwaseun; Myllymaa, Sami; Töyräs, Juha; Leppänen, Timo. IEEE journal of biomedical and health informatics 24 7: 2073-2081. 2019

Near-infrared spectroscopy based arthroscopic evaluation of human knee joint cartilage, through automated selection of an anatomically specific regression model

Prakash, Mithilesh; Joukainen, Antti; Sarin, Jaakko; Rieppo, Lassi; Afara, Isaac; Töyräs, Juha / Optical Tomography and Spectroscopy 2018. 2018. 2018

Near Infrared Spectroscopic Evaluation of Ligament and Tendon Biomechanical Properties

Torniainen, Jari; Ristaniemi, Aapo; Sarin, Jaakko K; Mikkonen, Santtu; Afara, Isaac O; Stenroth, Lauri; Korhonen, Rami K; Töyräs, Juha. ANNALS OF BIOMEDICAL ENGINEERING 2019; 47 1: 213-222. 2018

Spectroscopic Evaluation of Post-Traumatic Osteoarthritis in Shetland Ponies

Sarin, Jaakko K; te Moller, Nikae; Brommer, Harold; van Weeren, René; Mancini, Irina; Malda, Josa; Afara, Isaac O; Töyräs, Juha / Optical Tomography and Spectroscopy 2018. 2018. 2018

Arthroscopic near infrared spectroscopy enables simultaneous quantitative evaluation of articular cartilage and subchondral bone in vivo

Sarin, Jaakko K; Te Moller, Nikae CR; Mancini, Irina AD; Brommer, Harold; Visser, Jetze; Malda, Jos; van Weeren, PR; Afara, Isaac O; Töyräs, Juha. Scientific reports 8 1: 13409. 2018

Bayesian Network Model to Evaluate the Effectiveness of Continuous Positive Airway Pressure Treatment of Sleep Apnea

Ryynänen, Olli-Pekka; Leppänen, Timo; Kekolahti, Pekka; Mervaala, Esa; Töyräs, Juha. Healthcare Informatics Research 24 4: 346-358. 2018

Accounting for spatial dependency in multivariate spectroscopic data

Prakash, M; Sarin, JK; Rieppo, L; Afara IO; Töyräs, J. CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS 182: 166-171. 2018

Multi-scale imaging techniques to investigate solute transport across articular cartilage

Pouran, Behdad; Arbabi, Vahid; Bajpayee, Ambika G; van Tiel, Jasper; Töyras, Juha; Jurvelin, Jukka S; Malda, Jos; Zadpoor, Amir A; Weinans, Harrie. JOURNAL OF BIOMECHANICS 78: 10-20. 2018

Quantitative susceptibility mapping of articular cartilage: Ex vivo findings at multiple orientations and following different degradation treatments

Nykänen, O; Rieppo, L; Töyräs, J; Kolehmainen, V; Saarakkala, S; Shmueli, K; Nissi, MJ. Magnetic resonance in medicine 80 6: 2702-2716. 2018

Near-infrared spectroscopy: A potential tool for mapping meniscus properties

Ala-Myllymäki, Juho P.; Töyräs, Juha; Afara, Isaac O. / Biophotonics Congress: Biomedical Optics Congress 2018 (Microscopy/Translational/Brain/OTS). 2018. 2018

Home Polysomnography Reveals a First-Night Effect in Patients With Low Sleep Bruxism Activity

Miettinen, Tomi; Myllymaa, Katja; Hukkanen, Taina; Töyräs, Juha; Sipilä, Kirsi; Myllymaa, Sami. Journal of clinical sleep medicine 14 8: 1377-1386. 2018

Method for Segmentation of Knee Articular Cartilages Based on Contrast-Enhanced CT Images

Myller, Katariina AH; Honkanen, Juuso TJ; Jurvelin, Jukka S; Saarakkala, Simo; Töyräs, Juha; Väänänen, Sami P. Annals of biomedical engineering 46 11: 1756-1767. 2018

Differences in arousal probability and duration after apnea and hypopnea events in adult obstructive sleep apnea patients

Leppänen, Timo; Kulkas, Antti; Oksenberg, Arie; Duce, Brett; Mervaala, Esa; Töyräs, Juha. PHYSIOLOGICAL MEASUREMENT 39 11: 114004. 2018

Increase in Body Mass Index Decreases Duration of Apneas and Hypopneas in Obstructive Sleep Apnea

Leppänen, Timo; Kulkas, Antti; Mervaala, Esa; Töyräs, Juha. Respiratory care 2019; 64 1: 77-84. 2018

Simulation of Required CPAP Usage to Normalize AHI in Obstructive Sleep Apnea Patients

Kulkas, Antti; Nikkonen, Sami; Töyräs, Juha; Mervaala, Esa; Leppänen, Timo. Teoksessa: Lhotska, L; Sukupova, L; Lackovic, I; Ibbott, G (toim.), World Congress on Medical Physics and Biomedical Engineering 2018, June 3-8, 2018, Prague, Czech Republic (Vol.2). Springer. IFMBE Proceedings 68/2. s. 129-132. 2018

Required CPAP usage time to normalize AHI in obstructive sleep apnea patients: a simulation study

Kulkas, Antti; Leppänen, Timo; Nikkonen, Sami; Oksenberg, Arie; Duce, Brett; Mervaala, Esa; Töyräs, Juha. PHYSIOLOGICAL MEASUREMENT 39 11: 115009. 2018

Estimating Mechanical Properties of Bovine Knee Ligaments and Tendons with Near Infrared Spectroscopy

Torniainen, Jari E; Ristaniemi, Aapo; Stenroth, Lauri; Töyräs, Juha / Biophotonics Congress: Biomedical Optics Congress 2018 (Microscopy/Translational/Brain/OTS). 2018. 2018

Deep Learning Classification of Cartilage Integrity Using Near Infrared Spectroscopy

Afara, Isaac O.; Sarin, Jaakko K.; Ojanen, Simo; Finnilä, Mikko; Herzog, Walter; Saarakkala, Simo; Korhonen, Rami; Töyräs, Juha / Biophotonics Congress: Biomedical Optics Congress 2018 (Microscopy/Translational/Brain/OTS). 2018. 2018

Comparison between kinetic and kinetic-kinematic driven knee joint finite element models

Bolcos, PO; Mononen, ME; Mohammadi, A; Ebrahimi, M; Tanaka, MS; Samaan, MA; Souza, RB; Li, X; Suomalainen, JS; Jurvelin, JS; Töyräs, J; Korhonen, RK. Scientific Reports 8: 17351. 2018

Quantitative Dual Contrast CT Technique for Evaluation of Articular Cartilage Properties

Bhattarai, A; Honkanen, JTJ; Myller, KAH; Prakash, M; Korhonen M; Saukko, AEA; Virén, T; Joukainen, A; Patwa, AN; Kröger, H; Grinstaf, MW; Jurvelin, JS; Töyräs, J;. Annals of biomedical engineering 46 7: 1038-1046. 2018

Characterizing human subchondral bone properties using near-infrared (NIR) spectroscopy

Afara, IO; Florea, C; Olumegbon, IA; Eneh, CT; Malo, MKH; Korhonen, RK; Töyräs, J. Scientific Reports 8 1: 9733. 2018

Regular chondrocyte spacing is a potential cause for coherent ultrasound backscatter in human articular cartilage

Rohrbach D, Inkinen SI, Zatloukalová J, Kadow-Romacker A, Joukainen A, Malo MK, Mamou J, Töyräs J, Raum K. The Journal of the Acoustical Society of America 141 5: 3105-3116. 2017

Optimal Regression Method for Near-Infrared Spectroscopic Evaluation of Articular Cartilage

Prakash M, Sarin JK, Rieppo L, Afara IO, Töyräs J. APPLIED SPECTROSCOPY 71 10: 2253-2262. 2017

Infrared microspectroscopic determination of collagen cross-links in articular cartilage

Rieppo L, Kokkonen HT, Kulmala KAM, Kovanen V, Lammi MJ, Töyräs J, Saarakkala S. Journal of Biomedical Optics 22 3: 035007. 2017

Ultrasound Assessment of Human Meniscus

Viren T, Honkanen JT, Danso EK, Rieppo L, Korhonen RK, Töyräs J. ULTRASOUND IN MEDICINE AND BIOLOGY 43 9: 1753-1763. 2017

Combination of optical coherence tomography and near infrared spectroscopy enhances determination of articular cartilage composition and structure

Sarin Jaakko K, Rieppo Lassi, Brommer Harold, Afara Isaac O, Saarakkala Simo, Töyräs Juha. Scientific Reports 7 1: 10586. 2017

Multimodality scoring of chondral injuries in the equine fetlock joint ex vivo

Sarin Jaakko Kalevi, Brommer Harold, Argüelles David, Puhakka Pia Henriikka, Inkinen Satu Irene, Afara Isaac Oluwaseun, Saarakkala Simo, Töyräs Juha. OSTEOARTHRITIS AND CARTILAGE 25 5: 790-798. 2017

Corrigendum to "Multimodality scoring of chondral injuries in the equine fetlock joint ex vivo" [Osteoarthritis Cartilage 25 (5) (2017 May) 790-798].

Sarin JK, Brommer H, Argüelles D, Puhakka PH, Inkinen SI, Afara IO, Saarakkala S, Töyräs J. Osteoarthritis and cartilage 25 8: 1377-1378. 2017

Dual Contrast CT Method Enables Diagnostics of Cartilage Injuries and Degeneration Using a Single CT Image

Saukko Annina EA, Honkanen Juuso TJ, Xu Wujun, Väänänen Sami P, Jurvelin Jukka S, Lehto Vesa-Pekka, Töyräs Juha. ANNALS OF BIOMEDICAL ENGINEERING 45 12: 2857-2866. 2017

Success Rate and Technical Quality of Home Polysomnography with Self-Applicable Electrode Set in Subjects with Possible Sleep Bruxism

Miettinen T, Myllymaa K, Westeren-Punnonen S, Ahlberg J, Hukkanen T, Töyräs J, Lappalainen R, Mervaala E, Sipilä K, Myllymaa S. IEEE journal of biomedical and health informatics 120; 22 4: 1124-1132. 2017

Peri-apneic hemodynamic reactions in obstructive sleep apnea

Muraja-Murro Anu, Nieminen Outi, Julkunen Petro, Töyräs Juha, Laitinen Tomi, Mervaala Esa. PATHOPHYSIOLOGY 24 3: 197-203. 2017

Tissue viscoelasticity is related to tissue composition but may not fully predict the apparent-level viscoelasticity in human trabecular bone - An experimental and finite element study

Ojanen X, Tanska P, Malo MKH, Isaksson H, Väänänen SP, Koistinen AP, Grassi L, Magnusson SP, Ribel-Madsen SM, Korhonen RK, Jurvelin JS, Töyräs J. JOURNAL OF BIOMECHANICS 65: 96-105. 2017

At-home quantification of sleep characteristics with self-applicable facial electrode set

Miettinen T, Myllymaa K, Westeren-Punnonen S, Ahlberg J, Hukkanen T, Töyräs J, Lappalainen R, Mervaala E, Sipilä K, Myllymaa S. SLEEP MEDICINE 40 Supplement 1: e233-e234. 2017

New approach for determining cartilage pore size distribution: NaCl-thermoporometry

Majda D, Bhattarai A, Riikonen J, Napruszewska BD, Zimowska M, Michalik-Zym A, Töyräs J, Lehto V-P. Microporous and Mesoporous Materials 241: 238-245. 2017

Severity of individual obstruction events increases with age in patients with obstructive sleep apnea

Leppänen Timo, Töyräs Juha, Mervaala Esa, Penzel Thomas, Kulkas Antti. SLEEP MEDICINE 37: 32-37. 2017

Infrared thermography reveals effect of working posture on skin temperature in office workers

Lasanen, R; Malo, MKH; Airaksinen, O; Karhu, J; Töyräs, J; Julkunen, P. INTERNATIONAL JOURNAL OF OCCUPATIONAL SAFETY AND ERGONOMICS 2018; 24 3: 457-463. 2017

Severity of desaturation events differs between hypopnea and obstructive apnea events and is modulated by their duration in obstructive sleep apnea

Kulkas Antti, Duce Brett, Leppänen Timo, Hukins Craig, Töyräs Juha. Sleep and Breathing 21 4: 829-835. 2017

Gender differences in severity of desaturation events following hypopnea and obstructive apnea events in adults during sleep

Kulkas Antti, Duce Brett, Leppänen Timo, Hukins Craig, Töyräs Juha. PHYSIOLOGICAL MEASUREMENT 38 8: 1490-1502. 2017

Ultrasound Arthroscopy of Hip in Treatment of Osteochondritis Dissecans

Joukainen A, Virén T, Penttilä P, Liukkonen J, Puhakka PH, Kröger H, Töyräs J. Arthroscopy Techniques 6 4: e1063-e1068. 2017

Porosity predicted from ultrasound backscatter using multivariate analysis can improve accuracy of cortical bone thickness assessment

Eneh Chibuzor TM, Afara Isaac O, Malo Markus KH, Jurvelin Jukka S, Töyräs Juha. The Journal of the Acoustical Society of America 141 1: 575-585. 2017

The prevalence of REM-related obstructive sleep apnoea is reduced by the AASM 2012 hypopnoea criteria

Duce Brett, Kulkas Antti, Langton Christian, Töyräs Juha, Hukins Craig. Sleep and Breathing 2018; 22 1: 57-64. 2017

Optical spectroscopic characterization of human meniscus biomechanical properties

Ala-Myllymäki Juho, Danso Elvis K, Honkanen Juuso TJ, Korhonen Rami K, Töyräs J, Afara Isaac O. Journal of Biomedical Optics 22 12: 125008 (10 pages). 2017

Screen-printed ambulatory electrode set enables accurate diagnostics of sleep bruxism

Miettinen T, Myllymaa K, Muraja-Murro A, Westeren-Punnonen S, Hukkanen T, Töyräs J, Lappalainen R, Mervaala E, Sipilä K, Myllymaa S. Journal of Sleep Research 2018; 27 1: 103-112. 2017

Effect of collagen cross-linking on quantitative MRI parameters of articular cartilage

Rautiainen J, Nieminen MT, Salo EN, Kokkonen HT, Mangia S, Michaeli S, Gröhn O, Jurvelin JS, Töyräs J, Nissi MJ. OSTEOARTHRITIS AND CARTILAGE 24 9: 1656-1664. 2016

Assessment of the suitability of using a forehead EEG electrode set and chin EMG electrodes for sleep staging in polysomnography

Myllymaa Sami, Muraja-Murro Anu, Westeren-Punnonen Susanna, Hukkanen Taina, Lappalainen Reijo, Mervaala Esa, Töyräs Juha, Sipilä Kirsi, Myllymaa Katja. Journal of Sleep Research [Epub ahead of print 27 May 2016]: 1-10. 2016

Species-Independent Modeling of High-Frequency Ultrasound Backscatter in Hyaline Cartilage

Männicke Nils, Schöne Martin, Liukkonen Jukka, Fachet Dominik, Inkinen Satu, Malo Markus K, Oelze Michael L, Töyräs Juha, Jurvelin Jukka S, Raum Kay. ULTRASOUND IN MEDICINE AND BIOLOGY 42 6: 1375-1384. 2016

Differences in acoustic impedance of fresh and embedded human trabecular bone samples - scanning acoustic microscopy and numerical evaluation

Ojanen X, Töyräs J, Inkinen SI, Malo MKH, Isaksson H, Jurvelin JS. The Journal of the Acoustical Society of America 140 3: 1931-1936. 2016

Optical coherence tomography enables accurate measurement of equine cartilage thickness for determination of speed of sound

Puhakka PH, te Moller NCR, Tanska P, Saarakkala S, Tiitu V, Korhonen RK, Brommer H, Virén T, Jurvelin JS, Töyräs J. ACTA ORTHOPAEDICA 87 4: 418-424. 2016

Effect of bone inhomogeneity on tibiofemoral contact mechanics during physiological loading

Venäläinen MS, Mononen ME, Väänänen SP, Jurvelin JS, Töyräs J, Virén T, Korhonen RK. JOURNAL OF BIOMECHANICS 7 3: 1111-1120. 2016

Vibrational spectroscopy of articular cartilage

Rieppo Lassi, Töyräs Juha, Saarakkala Simo. Applied Spectroscopy Reviews [Published online 23 Aug 2016]: 1-18. 2016

Near Infrared Spectroscopic Mapping of Functional Properties of Equine Articular Cartilage

Sarin Jaakko K, Amissah Michael, Brommer Harold, Argüelles David, Töyräs Juha, Afara Isaac O. ANNALS OF BIOMEDICAL ENGINEERING 44 11: 3335-3345. 2016

Contrast-Enhanced Computed Tomography Enables Quantitative Evaluation of Tissue Properties at Intrajoint Regions in Cadaveric Knee Cartilage

Stewart Rachel C, Honkanen Juuso TJ, Kokkonen Harri T, Tiitu Virpi, Saarakkala Simo, Joukainen Antti, Snyder Brian D, Jurvelin Jukka S, Grinstaff Mark W, Töyräs Juha. Cartilage 8 4: 391-399. 2016

Semi-automated International Cartilage Repair Society scoring of equine articular cartilage lesions in optical coherence tomography images

Te Moller NC, Pitkänen M, Sarin JK, Väänänen S, Liukkonen J, Afara IO, Puhakka PH, Brommer H, Niemelä T, Tulamo RM, Arqüelles Capilla D, Töyräs J. EQUINE VETERINARY JOURNAL [Epub ahead of print 20 Oct 2016]: -. 2016

Quantitative Evaluation of the Mechanical Risks Caused by Focal Cartilage Defects in the Knee

Venäläinen Mikko S, Mononen Mika E, Salo Jari, Räsänen Lasse P, Jurvelin Jukka S, Töyräs Juha, Virén Tuomas, Korhonen Rami K. Scientific reports 6: 37538. 2016

In Vivo Contrast-Enhanced Cone Beam CT Provides Quantitative Information on Articular Cartilage and Subchondral Bone

Myller Katariina AH, Turunen Mikael J, Honkanen Juuso TJ, Väänänen Sami P, Iivarinen Jarkko T, Salo Jari, Jurvelin Jukka S, Töyräs Juha. ANNALS OF BIOMEDICAL ENGINEERING [Epub ahead of print 19 Sept 2016]: 1-8. 2016

Length of Individual Apnea Events Is Increased by Supine Position and Modulated by Severity of Obstructive Sleep Apnea

Leppänen Timo, Töyräs Juha, Muraja-Murro Anu, Kupari Salla, Tiihonen Pekka, Mervaala Esa, Kulkas Antti. Sleep Disorders 2016: 1-13. 2016

Phased-array ultrasound technology enhances accuracy of dual frequency ultrasound measurements - towards improved ultrasound bone diagnostics

Linder H, Malo MK, Liukkonen J, Jurvelin JS, Töyräs J. JOURNAL OF MEDICAL ENGINEERING & TECHNOLOGY 40 6: 293-297. 2016

Importance of patella, quadriceps forces, and depthwise cartilage structure on knee joint motion and cartilage response during gait

Halonen KS, Mononen ME, Jurvelin JS, Töyräs J, Klodowski A, Kulmala JP, Korhonen RK. JOURNAL OF BIOMECHANICAL ENGINEERING 138 7: BIO-15-1348, 11 pages. 2016

Structure-function relationships of human meniscus

Danso EK, Oinas JM, Saarakkala S, Mikkonen S, Töyräs J, Korhonen RK. Journal of the Mechanical Behavior of Biomedical Materials 67 March 2017: 51-60. 2016

RemLogic plug-in enables clinical application of apnea-hypopnea index adjusted for severity of individual obstruction events

Leppänen Timo, Särkkä Mikko, Kulkas Antti, Muraja-Murro Anu, Kupari Salla, Anttonen Meri, Tiihonen Pekka, Mervaala Esa, Töyräs Juha. JOURNAL OF MEDICAL ENGINEERING & TECHNOLOGY 40 3: 119-126. 2016

The AASM 2012 recommended hypopnea criteria increase the incidence of obstructive sleep apnea but not the proportion of positional obstructive sleep apnea

Duce B, Kulkas A, Langton C, Töyräs J, Hukins C. SLEEP MEDICINE 26: 23-29. 2016

Effect of porosity, tissue density, and mechanical properties on radial sound speed in human cortical bone

Eneh CTM, Malo MKH, Karjalainen JP, Liukkonen J, Töyräs J, Jurvelin JS. MEDICAL PHYSICS 43 5: 2030-2039. 2016

Amsterdam positional OSA classification: the AASM 2012 recommended hypopnoea criteria increases the number of positional therapy candidates

Duce B, Kulkas A, Langton C, Töyräs J, Hukins C. Sleep and Breathing First Online: 11 November 2016: 1-7. 2016

Optimal graft stiffness and pre-strain restore normal joint motion and cartilage responses in ACL reconstructed knee

Halonen KS, Mononen ME, Töyräs J, Kröger H, Joukainen A, Korhonen RK. JOURNAL OF BIOMECHANICS 49 13: 2566-2576. 2016

Cationic Contrast Agent Diffusion Differs Between Cartilage and Meniscus

Honkanen Juuso TJ, Mikael J, Freedman Jonathan D, Saarakkala Simo, Grinstaff Mark W, Ylärinne Janne H, Jurvelin Jukka S, Töyräs Juha. ANNALS OF BIOMEDICAL ENGINEERING 44 10: 2913-2921. 2016

Estimation of Systematic and Spatially Correlated Components of Random Signals from Repeated Measurements: Application to Contrast Enhanced Computer Tomography Measurements

Huttunen JMJ, Turunen MJ, Honkanen JTJ, Töyräs J, Jurvelin JS. SIAM JOURNAL ON SCIENTIFIC COMPUTING 38 1: B77-B99. 2016

Finite difference time domain model of ultrasound propagation in agarose scaffold containing collagen or chondrocytes

Inkinen SI, Liukkonen J, Malo MK, Virén T, Jurvelin JS, Töyräs J. The Journal of the Acoustical Society of America 140 1: 1. 2016

Solute transport of negatively charged contrast agents across articular surface of injured cartilage

Kokkonen HT, Chin HC, Töyräs J, Jurvelin JS, Quinn TM. ANNALS OF BIOMEDICAL ENGINEERING First Online: 08 November 2016: 1-9. 2016

Severity of individual obstruction events is gender dependent in sleep apnea

Leppänen Timo, Kulkas Antti, Duce Brett, Mervaala Esa, Töyräs Juha. Sleep and Breathing First Online: 13 December 2016: 1-8. 2016

Quantitative evaluation of knee subchondral bone mineral density using cone beam computed tomography

Turunen Mikael J, Töyräs Juha, Kokkonen Harri T, Jurvelin Jukka S. IEEE TRANSACTIONS ON MEDICAL IMAGING 34 10: 2186-2190. 2015

Estimation of articular cartilage properties using multivariate analysis of optical coherence tomography signal

Puhakka PH, Te Moller NC, Afara IO, Mäkelä JT, Tiitu V, Korhonen RK, Brommer H, Virén T, Jurvelin JS, Töyräs J. OSTEOARTHRITIS AND CARTILAGE 23 12: 2206-2213. 2015

In Vivo Evaluation of the Potential of High-Frequency Ultrasound for Arthroscopic Examination of the Shoulder Joint

Puhakka Jani, Afara Isaac O, Paatela Teemu, Sormaala Markus J, Timonen Matti A, Virén Tuomas, Jurvelin Jukka S, Töyräs Juha, Kiviranta Ilkka. Cartilage 2016; 7 3: 248-255. 2015

Diagnosis of Knee Osteochondral Lesions With Ultrasound Imaging

Penttilä Pekko, Liukkonen Jukka, Joukainen Antti, Virén Tuomas, Jurvelin Jukka S, Töyräs Juha, Kröger Heikki. Arthroscopy Techniques 4 5: e429-e433. 2015

Effect of different oxygen desaturation threshold levels on hypopnea scoring and classification of severity of sleep apnea

Myllymaa Sami, Myllymaa Katja, Kupari Salla, Kulkas Antti, Leppänen Timo, Tiihonen Pekka, Mervaala Esa, Seppä Juha, Tuomilehto Henri, Töyräs Juha. Sleep and Breathing 19 3: 947-954. 2015

Effect of oxygen desaturation threshold on determination of OSA severity during weight loss

Myllymaa Katja, Myllymaa Sami, Leppänen Timo, Kulkas Antti, Kupari Salla, Tiihonen Pekka, Mervaala Esa, Seppä Juha, Tuomilehto Henri, Töyräs Juha. Sleep and Breathing 2016; 20 1: 33-42. 2015

Forehead EEG electrode set versus full-head scalp EEG in 100 patients with altered mental state

Muraja-Murro Anu, Mervaala Esa, Westeren-Punnonen Susanna, Lepola Pasi, Töyräs Juha, Myllymaa Sami, Julkunen Petro, Kantanen Anne-Mari, Kälviäinen Reetta, Myllymaa Katja. EPILEPSY & BEHAVIOR 49: 245-249. 2015

Menthol concentration in topical cold gel does not have significant effect on skin cooling

Lasanen R, Julkunen P, Airaksinen O, Töyräs J. SKIN RESEARCH AND TECHNOLOGY 2016; 22 1: 40-45. 2015

A Handy EEG Electrode Set for patients suffering from altered mental state

Lepola Pasi, Myllymaa Sami, Töyräs Juha, Hukkanen Taina, Mervaala Esa, Määttä Sara, Lappalainen Reijo Myllymaa Katja. JOURNAL OF CLINICAL MONITORING AND COMPUTING 29 6: 697-705. 2015

Thermal imaging in screening of joint inflammation and rheumatoid arthritis in children

Lasanen R, Piippo-Savolainen E, Remes-Pakarinen T, Kröger L, Heikkilä A., Julkunen P., Karhu J, Töyräs J. PHYSIOLOGICAL MEASUREMENT 36 2: 273-282. 2015

Articular cartilage repair with recombinant human type II collagen/polylactide scaffold in a preliminary porcine study

Muhonen Virpi, Salonius Eve, Haaparanta Anne-Marie, Järvinen Elina, Paatela Teemu, Meller Anna, Hannula Markus, Björkman Mimmi, Pyhältö Tuomo, Ellä Ville, Vasara Anna, Töyräs Juha, Kellomäki Minna, Kiviranta Ilkka. JOURNAL OF ORTHOPAEDIC RESEARCH 2016; 34 5: 745-753. 2015

Amount of weight loss or gain influences the severity of respiratory events in sleep apnea

Kulkas A, Leppänen T, Sahlman J, Tiihonen P, Mervaala E, Kokkarinen J, Randell J, Seppä J, Töyräs J, Tuomilehto H. MEDICAL AND BIOLOGICAL ENGINEERING AND COMPUTING epub 17 Apr 2015: 14 p. 2015

Inter-individual changes in cortical bone three-dimensional microstructure and elastic coefficient have opposite effects on radial sound speed

Eneh Chibuzor TM, Liukkonen Jukka, Malo Markus KH, Jurvelin Jukka S, Töyräs Juha. The Journal of the Acoustical Society of America 138 6: 3491. 2015

New method for point-of-care osteoporosis screening and diagnostics

Karjalainen JP, Riekkinen O, Töyräs J, Jurvelin JS, Kröger H. OSTEOPOROSIS INTERNATIONAL 2016; 27 3: 971-977. 2015

Optical absorption spectra of human articular cartilage correlate with biomechanical properties, histological score and biochemical composition

Afara Isaac O, Hauta-Kasari Markku, Jurvelin Jukka S, Oloyede Adekunle, Töyräs Juha. PHYSIOLOGICAL MEASUREMENT 36 9: 1913-1928. 2015

Characterization of site-specific biomechanical properties of human meniscus-Importance of collagen and fluid on mechanical nonlinearities

Danso EK, Mäkelä JTA, Tanska P, Mononen ME, Honkanen JTJ, Jurvelin JS, Töyräs J, Julkunen P, Korhonen RK. JOURNAL OF BIOMECHANICS 48 8: 1499-1507. 2015

Optical spectroscopic determination of human meniscus composition

Ala-Myllymäki Juho, Honkanen Juuso TJ, Töyräs Juha, Afara Isaac O. JOURNAL OF ORTHOPAEDIC RESEARCH 2016; 34 2: 270-278. 2015

Comparison of subchondral bone density and structure of tibia measured from plain radiograph with micro-computed tomography

Hirvasniemi J., Kokkonen H. T., Thevenot J., Finnilä M., Venäläinen M. S., Jämsä T., Korhonen R. K., Töyräs J., Saarakkala S.. OSTEOARTHRITIS AND CARTILAGE 23: A234-A235. 2015

Correlation of Subchondral Bone Density and Structure from Plain Radiographs with Micro Computed Tomography Ex Vivo

Hirvasniemi Jukka, Thevenot Jérôme, Kokkonen Harri T, Finnilä Mikko A, Venäläinen Mikko S, Jämsä Timo, Korhonen Rami K, Töyräs Juha, Saarakkala Simo. ANNALS OF BIOMEDICAL ENGINEERING 44: 1698. 2015

Importance of Material Properties and Porosity of Bone on Mechanical Response of Articular Cartilage in Human Knee Joint - A Two-Dimensional Finite Element Study

Venäläinen Mikko S, Mononen Mika E, Jurvelin Jukka S, Töyräs Juha, Virén Tuomas, Korhonen Rami K. JOURNAL OF BIOMECHANICAL ENGINEERING 136 12: 121005. 2014

Effects of freeze-thaw cycle with and without proteolysis inhibitors and cryopreservant on the biochemical and biomechanical properties of articular cartilage

Qu Chengjuan, Hirviniemi Mikko, Tiitu Virpi, Jurvelin Jukka S, Töyräs Juha, Lammi Mikko J. Cartilage 5 2: 97-106. 2014

Dependence of light attenuation and backscattering on collagen concentration and chondrocyte density in agarose scaffolds

Puhakka PH, Ylärinne JH, Lammi MJ, Saarakkala S, Tiitu V, Kröger H, Virén T, Jurvelin JS, Töyräs J. PHYSICS IN MEDICINE AND BIOLOGY 59 21: 6537-48. 2014

Relationships Between Tissue Composition and Viscoelastic Properties in Human Trabecular Bone

Ojanen X, Isaksson H, Töyräs J, Turunen MJ, Malo MKH, Halvari A, Jurvelin JS. JOURNAL OF BIOMECHANICS Epub 2014 Dec 3: 269-275. 2014

Application of optical coherence tomography enhances reproducibility of arthroscopic evaluation of equine joints

Niemelä Tytti, Virén Tuomas, Liukkonen Jukka, Argüelles David, te Moller Nikae CR, Puhakka Pia H, Jurvelin Jukka S, Tulamo Riitta-Mari, Töyräs Juha. ACTA VETERINARIA SCANDINAVICA 56 3: -. 2014

Adjustment of apnea-hypopnea index with severity of obstruction events enhances detection of sleep apnea patients with the highest risk of severe health consequences

Muraja-Murro A, Kulkas A, Hiltunen M, Kupari S, Hukkanen T, Tiihonen P, Mervaala E, Töyräs J. Sleep and Breathing 18 3: 641-647. 2014

Ultrasound backscatter measurements of intact human proximal femurs - Relationships of ultrasound parameters with tissue structure and mineral density

Malo MKH, Töyräs J, Karjalainen JP, Isaksson H, Riekkinen O, Jurvelin JS. BONE 64: 240-245. 2014

Shielded design of screen-printed EEG electrode set reduces interference pick-up

Lepola Pasi, Myllymaa Sami, Töyräs Juha, Mervaala Esa, Lappalainen Reijo, Myllymaa Katja. IEEE SENSORS JOURNAL 14 8: 2692-2697. 2014

Screen-printed EEG electrode set for emergency use

Lepola Pasi, Myllymaa Sami, Töyräs Juha, Muraja-Murro Anu, Mervaala Esa, Lappalainen Reijo, Myllymaa Katja. SENSORS AND ACTUATORS A. PHYSICAL 213 July: 19-26. 2014

Arrangement and method for carrying out electrode measurements

Lappalainen R, Mervaala E, Myllymaa K, Myllymaa S, Töyräs J. WO 2014072582 A1. 2014

Morbidity and mortality risk ratios are elevated in severe supine dominant OSA: a long-term follow-up study

Kulkas A, Muraja-Murro A, Tiihonen P, Mervaala E, Töyräs J. Sleep and Breathing epub: 8 sivua. 2014

Weight loss alters severity of individual nocturnal respiratory events depending on sleeping position

Kulkas A, Leppänen T, Sahlman J, Tiihonen P, Mervaala E, Kokkarinen J, Randell J, Seppä J, Töyräs J, Tuomilehto H. PHYSIOLOGICAL MEASUREMENT 35 10: 2037-2052. 2014

Collagen and chondrocyte concentrations control ultrasound scattering in agarose scaffolds

Inkinen Satu, Liukkonen Jukka, Ylärinne Janne, Puhakka Pia, Lammi Mikko, Virén Tuomas, Jurvelin Jukka, Töyräs Juha. ULTRASOUND IN MEDICINE AND BIOLOGY 40 9: 2162-2171. 2014

Estimation of fixed charge density and diffusivity profiles in cartilage using contrast enhanced computer tomography

Huttunen JMJ, Kokkonen HT, Jurvelin JS, Töyräs J, Kaipio JP. INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN ENGINEERING 98 5: 371-390. 2014

Assessment of myocardial perfusion with MRI using a modified dual bolus method

Husso M, Sipola P, Kuittinen T, Manninen H, Vainio P, Hartikainen J, Saarakkala S, Töyräs J, Kuikka J. PHYSIOLOGICAL MEASUREMENT 35 4: 533-47. 2014

Deformation of articular cartilage during static loading of a knee joint - Experimental and finite element analysis

Halonen KS, Mononen ME, Jurvelin JS, Töyräs J, Salo J, Korhonen RK. JOURNAL OF BIOMECHANICS 47 10: 2467-2474. 2014

Ultrasound Arthroscopy of Human Knee Joint in vivo,

Liukkonen J, Lehenkari P, Hirvasniemi J, Joukainen A, Saarakkala S, Jurvelin J, Töyräs J. , ORS 2013 annual meeting. 1986. 2013

Arthroscopic optical coherence tomography provides detailed information on articular cartilage lesions in horses

te Moller, NCR; Brommer, H; Liukkonen, J; Virén T; Timonen M; Puhakka PH; Jurvelin JS; van Weeren PR; Töyräs J. The Veterinary Journal 197: 589-595. 2013

New disposable forehead electrode set with excellent signal quality and imaging compatibility

Myllymaa Sami, Lepola Pasi, Töyräs Juha, Hukkanen Taina, Mervaala Esa, Lappalainen Reijo, Myllymaa Katja. JOURNAL OF NEUROSCIENCE METHODS 215 1: 103-109. 2013

Novel screen printed electrode set for routine EEG recordings in patients with altered mental status

Myllymaa S, Lepola P, Hukkanen T, Oun A, Mervaala E, Toyras J, Lappalainen R, Myllymaa K. -, Engineering in Medicine and Biology Society (EMBC), 2013 35th Annual International Conference of the IEEE. Engineering in Medicine and Biology Society Proceedings. 6724-6727. 2013

The severity of individual obstruction events is related to increased mortality rate in severe obstructive sleep apnea

Muraja-Murro A, Kulkas A, Hiltunen M, Kupari S, Hukkanen T, Tiihonen P, Mervaala E, Töyräs J. Journal of Sleep Research 22 6: 663-669. 2013

Mortality in middle-aged men with obstructive sleep apnea in Finland

Muraja-Murro A, Eskola K, Kolari T, Tiihonen P, Hukkanen T, Tuomilehto H, Peltonen M, Mervaala E, Töyräs J. Sleep and Breathing 17 3: 1047-1053. 2013

Longitudinal elastic properties and porosity of cortical bone tissue vary with age in human proximal femur

Malo MK, Rohrbach D, Isaksson H, Töyräs J, Jurvelin JS, Tamminen IS, Kröger H, Raum K. BONE 53 2: 451-458. 2013

Ultrasound Arthroscopy of Human Knee Joint: Feasibility In Vivo

Liukkonen J, Lehenkari P, Hirvasniemi J, Joukainen A, Virén T, Saarakkala S, Nieminen M, Jurvelin JS, Töyräs J. , ESUCB 2013, 5th European Symposium on Ultrasonic Characterization of Bone. 50. 2013

Rustovaurioiden kehittyvä diagnostiikka - nopein hoitotuloksia parantava tekijä?

Salo J, Töyräs J, Joukainen A, Jurvelin J, Kröger H. SUOMEN ORTOPEDIA JA TRAUMATOLOGIA 36 3: 256-261. 2013

Arthroscopic ultrasound technique for simultaneous quantitative assessment of articular cartilage and subchondral bone: an in vitro and in vivo feasibility study

Liukkonen J, Hirvasniemi J, Joukainen A, Penttilä P, Virén T, Saarakkala S, Kröger H, Jurvelin JS, Töyräs J. ULTRASOUND IN MEDICINE AND BIOLOGY 39 8: 1460-1468. 2013

Novel parameters indicate significant differences in severity of obstructive sleep apnea with patients having similar apnea-hypopnea index

Kulkas A, Tiihonen P, Julkunen P, Mervaala E, Töyräs J. MEDICAL AND BIOLOGICAL ENGINEERING AND COMPUTING 51 6: 697-708. 2013

Desaturation delay, parameter for evaluating severity of sleep disordered breathing

Kulkas A, Tiihonen P, Julkunen P, Mervaala E, Töyräs J. Long M, World Congress on Medical Physics and Biomedical Engineering May 26-31, 2012, Beijing, China. IFMBE Proceedings 39. 336-339. 2013

Novel parameters for evaluating severity of sleep disordered breathing and for supporting diagnosis of sleep apnea-hypopnea syndrome

Kulkas A, Tiihonen P, Eskola K, Julkunen P, Mervaala E, Töyräs J. JOURNAL OF MEDICAL ENGINEERING & TECHNOLOGY 37 2: 135-143. 2013

Novel parameters reflect changes in morphology of respiratory events during weight loss

Kulkas A, Leppänen T, Sahlman J, Tiihonen P, Mervaala E, Kokkarinen J, Randell J, Seppä J, Tuomilehto H, Töyräs J. PHYSIOLOGICAL MEASUREMENT 34 9: 1013-1026. 2013

In vivo diagnostics of human knee cartilage lesions using delayed CBCT arthrography

Kokkonen HT, Suomalainen JS, Joukainen A, Kröger H, Sirola J, Jurvelin JS, Salo J, Töyräs J. JOURNAL OF ORTHOPAEDIC RESEARCH 2013 2014 Mar;32(3):403-12: 1-10. 2013

Importance of depth-wise distribution of collagen and proteoglycans in articular cartilage - A 3D finite element study of stresses and strains in human knee joint

Halonen KS, Mononen ME, Jurvelin JS, Töyräs J, Korhonen RK. JOURNAL OF BIOMECHANICS 46 6: 1184-1192. 2013

Collagen and Chondrocyte Content Control Ultrasound Scattering in Agarose Scaffolds

Inkinen, S; Liukkonen, J; Ylärinne, Puhakka, PH; J; Lammi, M; Virén, T; Jurvelin JS; Töyräs, J. , ORS 2013 annual meeting. 1214. 2013

Diffusion of ionic and non-ionic contrast agents in articular cartilage with increased cross-linking-contribution of steric and electrostatic effects

Kulmala KAM, Karjalainen HM, Kokkonen HT, Tiitu V, Kovanen V, Lammi MJ, Jurvelin JS, Korhonen RK, Töyräs J. MEDICAL ENGINEERING & PHYSICS 35 10: 1415-1420. 2013

Repair of osteochondral defects with recombinant human type II collagen gel and autologous chondrocytes in rabbit

Pulkkinen HJ, Tiitu V, Valonen P, Jurvelin JS, Rieppo L, Töyräs J, Silvast TS, Lammi MJ, Kiviranta I. OSTEOARTHRITIS AND CARTILAGE 2012 Dec 17. pii: S1063-4584(12)01049-7.: --. 2012

Ultrasonic evaluation of acute impact injury of articular cartilage in vitro

Virén T, Timonen M, Tyrväinen H, Tiitu V, Jurvelin JS, Töyräs J. OSTEOARTHRITIS AND CARTILAGE 20: 719-726. 2012

Comparison of ultrasound and optical coherence tomography techniques for evaluation of integrity of spontaneously repaired horse cartilage

Virén T, Huang YP, Saarakkala S, Pulkkinen H, Tiitu V, Linjama A, Kiviranta I, Lammi MJ, Brünott A, Van Weeren R, Brama PAJ, Zheng YP, Jurvelin JS, Töyräs J. JOURNAL OF MEDICAL ENGINEERING & TECHNOLOGY 36 3: 185-192. 2012

Bath concentration of anionic contrast agents does not affect their diffusion and distribution in articular cartilage in vitro

Silvast Tuomo, Jurvelin Jukka, Tiitu Virpi, Quinn Thomas, Töyräs Juha. Cartilage 2013; 4 1: 42-51. 2012

Diffusion of Gd-DTPA2- into articular cartilage

Salo E-N, Nissi MJ, Kulmala KAM, Tiitu V, Töyräs J, Nieminen MT. OSTEOARTHRITIS AND CARTILAGE 20 2: 117-126. 2012

Simultaneous quantitative ultrasound assessment of cartilage and subchondral bone

Liukkonen J, Hirvasniemi J, Joukainen A, Penttilä P, Virén T, Jurvelin, JS, Töyräs, J. , ORS 2012 annual meeting, Orthpaedic Research Society. 1443. 2012

Total duration of apnea and hypopnea events and average desaturation show significant variation in patients with a similar apnea-hypopnea index

Muraja-Murro A, Nurkkala J, Tiihonen P, Hukkanen T, Tuomilehto H, Kokkarinen J, Mervaala E, Töyräs J. JOURNAL OF MEDICAL ENGINEERING & TECHNOLOGY 36 8: 393-398. 2012

Delayed computed tomography artrography of human knee cartilage In Vivo

Kokkonen, Harri; Aula, Antti; Kröger, Heikki; Suomalainen, Juha-Sampo; Lammentausta, Eveliina; Mervaala, Esa; Jurvelin, Jukka; Töyräs, Juha. Cartilage 3 4: 334-341. 2012

Nondestructive fluorescence-based quantification of threose-induced collagen cross-linking in bovine articular cartilage

Kinnunen Jussi, Kokkonen Harri T, Kovanen Vuokko, Hauta-Kasari Markku, Vahimaa Pasi, Lammi Mikko J, Töyräs Juha, Jurvelin Jukka S. Journal of Biomedical Optics 17 9: 97003. 2012

Multi-site bone ultrasound measurements in elderly women with and without previous hip fractures

Karjalainen JP., Riekkinen O., Töyräs J., Hakulinen M., Kröger H., Rikkonen T., Salovaara K., Jurvelin JS.. OSTEOPOROSIS INTERNATIONAL 23: 1287-1295. 2012

Contrast-Enhanced Micro-Computed Tomography in Evaluation of Spontaneous Repair of Equine Cartilage

K.A.M. Kulmala, H.J. Pulkkinen, L. Rieppo, V. Tiitu, I. Kiviranta, A. Brünott, H. Brommer, R. van Weeren, P.A.J. Brama, M.T. Mikkola, R.K. Korhonen, J.S. Jurvelin, J.Töyräs. Cartilage 3 3: 235-244. 2012

In vivo comparison of delayed gadolinium-enhanced MRI of cartilage and delayed quantitative CT arthrography in imaging of articular cartilage

Hirvasniemi J, Kulmala KAM, Lammentausta E, Ojala R, Lehenkari P, Kamel A, Jurvelin JS, Töyräs J, Nieminen MT and Saarakkala S. OSTEOARTHRITIS AND CARTILAGE xx xx: xx. 2012

Effects of non-optimal focusing on dual-frequency ultrasound measurements of bone

Malo MK, Karjalainen JP, Riekkinen O, Isaksson H, Jurvelin JS, Töyräs J.. IEEE TRANSACTIONS ON ULTRASONICS, FERROELECTRICS, AND FREQUENCY CONTROL 58 6: 1182-1188. 2011

Ultrasound evaluation of mechanical injury of bovine knee articular cartilage under arthroscopic control

Virén Tuomas, Saarakkala Simo, Tiitu Virpi, Puhakka Jani, Kiviranta Ilkka, Jurvelin Jukka S, Töyräs Juha. IEEE TRANSACTIONS ON ULTRASONICS, FERROELECTRICS, AND FREQUENCY CONTROL 58 1: 148-154. 2011

Hyperosmolaric Contrast Agents in Cartilage Tomography May Expose Cartilage to Overload- Induced Cell Death

Turunen MJ, Töyräs J, Lammi MJ, Jurvelin JS, Korhonen RK. JOURNAL OF BIOMECHANICS 45: 497-503. 2011

Technical and practical improvements in arthroscopic indentation technique for diagnostics of articular cartilage softening

Timonen MA, Töyräs J, Aula AS, Karjalainen JP, Riekkinen O, Jurvelin JS. JOURNAL OF MEDICAL ENGINEERING & TECHNOLOGY 35 1: 40-46. 2011

Kartiokeila-TT kokeellisen rustovaurion diagnostiikassa

Salo J, Kokkonen HT, Kröger H, Jurvelin JS, Töyräs J. SUOMEN ORTOPEDIA JA TRAUMATOLOGIA 34 3: 288-289. 2011

Evaluation of Joint Cartilage and Subchondral Bone using Arthroscopic Ultrasound Imaging

Penttilä P, Liukkonen J, Joukainen A, Virén T, Jurvelin JS, Kröger H, Töyräs J. SUOMEN ORTOPEDIA JA TRAUMATOLOGIA 34 3: 229. 2011

Alterations in structure and properties of collagen network of osteoarthritic and repaired cartilage modify knee joint stresses

Mononen ME, Julkunen P, Toyras J, Jurvelin JS, Kiviranta I, Korhonen RK. BIOMECHANICS AND MODELING IN MECHANOBIOLOGY 10 3: 357-369. 2011

Computed tomography detects changes in contrast agent diffusion after collagen cross-linking typical to natural aging of articular cartilage

Kokkonen HT, Mäkelä J, Kulmala KAM, Rieppo L, Jurvelin JS, Tiitu V, Karjalainen HM, Korhonen RK, Kovanen V, Töyräs J. OSTEOARTHRITIS AND CARTILAGE 19: 1190-1198. 2011

Simultaneous quantitative ultrasound assessment of cartilage and subchondral bone

Liukkonen J, Aula A, Töyräs J, Jurvelin JS. , 4th European Symposium on Ultrasonic Characterization of Bone (ESUCB). 76. 2011

Contrast enhanced computed tomography in evaluation of spontaneous cartilage repair

Kulmala K.A.M, Pulkkinen H.J, Rieppo L, Tiitu V, Kiviranta I, Brünott A, Brommer H, van Weeren R, Brama P.A.J, Mikkola M.T, Korhonen R.K, Jurvelin J.S, Töyräs J.. Teoksessa: (toim.), 5th Osteoarthritis Imaging Workshop. ss. 6. 2011

Detection of mechanical injury of articular cartilage using contrast enhanced computed tomography

Kokkonen HT, Jurvelin JS, Tiitu V, Töyräs J. OSTEOARTHRITIS AND CARTILAGE 19: 297-301. 2011

Collagen cross-link modified fluorescence excitation-emission matrix of articular cartilage

Kinnunen Jussi, Hauta-Kasari Markku, Kokkonen Harri, Vahimaa Pasi, Lammi Mikko, Töyräs Juha, Jurvelin Jukka. N/A, Topical problems of biophotonics -2011, proceedings. 59-60. 2011

Arthroscopic Ultrasound Assessment of Articular Cartilage in the Human Knee Joint

Kaleva Erna, Viren Tuomas, Saarakkala Simo, Sahlman Janne, Sirola Joonas, Puhakka Jani, Paatela Teemu, Kröger Heikki, Kiviranta Ilkka, Jurvelin Jukka, Töyräs Juha. Cartilage 2 3: 246-253. 2011

Structural parameters of normal and osteoporotic human trabecular bone are affected differently by microCT image resolution

Isaksson, Hanna; Töyräs, J; Hakulinen, M; Aula, AS; Tamminen, Inari; Julkunen, P; Kröger, Heikki; Jurvelin, Jukka. OSTEOPOROSIS INTERNATIONAL 22 1: 167-177. 2011

Effects of optical beam angle on quantitative optical coherence tomography (OCT) in normal and surface degenerated bovine articular cartilage.

Huang YP, Saarakkala S, Töyräs J, Wang LK, Jurvelin JS, Zheng YP.. PHYSICS IN MEDICINE AND BIOLOGY 56 2: 491-509. 2011

Dynamics of contrast agent enhancement of intact and enzymatically degraded articular cartilage

Salo, E-N., Nissi, M. J., Kulmala K. A., Töyräs J., Nieminen M. T.. , Proceedings of the International Society of Magnetic Resonance in Medicine 18. 3177. 2010

Diffusivity and kinetics of gadopentetate in articular cartilage in vitro

Salo, E-N., Nissi, M. J., Kulmala K. A., Töyräs J., Nieminen M. T.. Teoksessa: (toim.), Proceedings of the International Society of Magnetic Resonance in Medicine 18. ss. 234. 2010

Temporal dynamics and diffusion of gadopentetate in articular cartilage at MRI concentrations in vitro

Salo E-N., Nissi M. J., Kulmala K., Töyräs J., Nieminen M. T.. , Transactions of the Orthopaedic Research Society 35. 1348. 2010

Effect of Degenerative Changes of Articular Cartilage on Knee Joint Stresses ¿ Functional Imaging by Combining Clinical MRI and Finite Element Modeling

Mononen, M E; Julkunen, P; Jurvelin, J S; Töyräs, J; Korhonen, R K. Teoksessa: Smith & Nephew, Inc. (toim.), Transactions of the Orthopaedic Research Society. ss. 865. 2010

Diffusion of CT and MRI contrast agents in articular cartilage in vitro

Kulmala KAM, Korhonen RK, Julkunen P, Jurvelin JS, Quinn TM, Kröger H, Töyräs J. Teoksessa: (toim.), Transactions of the Orthopaedic Research Society. ss. 1352. 2010

Diffusion coefficients of articular cartilage for different CT and MRI contrast agents

Kulmala K.A.M.,Korhonen R.K.,Julkunen P,Jurvelin J.S.,Quinn T.M.,Kröger H,Töyräs J. MEDICAL ENGINEERING & PHYSICS 32: 878-882. 2010

2-D Finite Difference Time Domain Model of Ultrasound Reflection From Normal and Osteoarthritic Human Articular Cartilage Surface

Kaleva E., Liukkonen J, Töyräs J, Saarakkala S, Kiviranta P, and Jurvelin JS. IEEE TRANSACTIONS ON ULTRASONICS, FERROELECTRICS, AND FREQUENCY CONTROL 57 4: 892-9. 2010

Bone Quantitative Ultrasound

Laugier P. and Haiat G.. 2010 2010

Simultaneous ultrasound measurement of articular cartilage and subchondral bone

Aula AS, Töyräs J, Tiitu V, Jurvelin JS. OSTEOARTHRITIS AND CARTILAGE 18 12: 1570-1576. 2010

Contrast agent-enhanced computed tomography of articular cartilage: association with tissue composition and properties

Silvast TS, Jurvelin JS, Aula AS, Lammi MJ, Töyräs J. ACTA RADIOLOGICA 50 1: 78-85. 2009

Minimally invasive ultrasound method for intra-articular diagnostics of cartilage degeneration

Viren T, Saarakkala S, Kaleva E, Nieminen HJ, Jurvelin JS, Töyräs J. ULTRASOUND IN MEDICINE AND BIOLOGY 35 9: 1546-1554. 2009

Design, construction and evaluation of an ambulatory device for screening of sleep apnea

Tiihonen P, Pääkkönen A, Mervaala E, Hukkanen T, Töyräs J. MEDICAL AND BIOLOGICAL ENGINEERING AND COMPUTING 47: 59-66. 2009

Evaluation of a novel ambulatory device for screening of sleep apnea

Tiihonen P, Hukkanen T, Tuomilehto H, Mervaala E, Töyräs J. TELEMEDICINE JOURNAL AND E-HEALTH 15 3: 283-289. 2009

Accuracy of automatic analysis of ambulatory recordings of nocturnal breathing disorders is significantly instrumentation dependent

Tiihonen P, Hukkanen T, Tuomilehto H, Mervaala E, Pääkkönen A, Töyräs J. JOURNAL OF MEDICAL ENGINEERING & TECHNOLOGY 33 5: 386-393. 2009

Diffusion and near-equilibrium distribution of MRI and CT contrast agents in articular cartilage

Silvast TS, Kokkonen HT, Jurvelin JS, Quinn TM, Nieminen MT, Töyräs J. PHYSICS IN MEDICINE AND BIOLOGY 54: 6823-6836. 2009

pQCT study on diffusion and equilibrium distribution of iodinated anionic contrast agent in human articular cartilage - associations to matrix composition and integrity

Silvast TS, Jurvelin JS, Lammi MJ, Töyräs J. OSTEOARTHRITIS AND CARTILAGE 17: 26-32. 2009

Simultaneous computed tomography of articular cartilage and subchondral bone

Aula AS, Jurvelin JS, Töyräs J. OSTEOARTHRITIS AND CARTILAGE 17: 1583-1588. 2009

Fabrication and testing of polyimide-based microelectrode arrays for cortical mapping of evoked potentials

Myllymaa S, Myllymaa K, Korhonen H, Töyräs J, Jääskeläinen JE, Djupsund K, Tanila H, Lappalainen R. BIOSENSORS AND BIOELECTRONICS 24: 3067-3072. 2009

Differences in acoustic properties of intact and degenerated human patellar cartilage during compression

Kiviranta P, Lammentausta E, Töyräs J, Nieminen HJ, Julkunen P, Kiviranta I, Jurvelin JS. ULTRASOUND IN MEDICINE AND BIOLOGY 35 8: 1367-1375. 2009

Ultrasound backscatter imaging provides frequency-dependent information on structure, composition and mechanical properties of human trabecular bone

Karjalainen JP, Töyräs J, Riekkinen O, Hakulinen M, Jurvelin JS. ULTRASOUND IN MEDICINE AND BIOLOGY 35 8: 1376-1384. 2009

Ultrasound backscattering outperforms the clinically used ultrasound parameters in discrimination of osteoporotic-like human trabecular bone samples

Karjalainen J, Töyräs J, Riekkinen O, Hakulinen MA. Dössel O, Schlegel WC, World Congress on Medical Physics and Biomedical Engineering. Diagnostic Imaging. IFMBE Proceedings.Springer. 94-97. 2009

Effects of ultrasound frequency, temporal sampling frequency, and spatial sampling step on the quantitative ultrasound parameters of articular cartilage

Kaleva E, Töyräs J, Jurvelin JS, Viren T, Saarakkala S. IEEE TRANSACTIONS ON ULTRASONICS, FERROELECTRICS, AND FREQUENCY CONTROL 56 7: 1383-1393. 2009

Effects of ultrasound beam angle and surface roughness on the quantitative ultrasound parameters of articular cartilage

Kaleva E, Saarakkala S, Jurvelin JS, Viren T, Töyräs J. ULTRASOUND IN MEDICINE AND BIOLOGY 35 8: 1344-1351. 2009

Effect of bone marrow on acoustic properties of trabecular bone - 3D finite difference modelling study

Aula AS, Töyräs J, Hakulinen MA, Jurvelin JS. ULTRASOUND IN MEDICINE AND BIOLOGY 35 2: 308-318. 2009

Strain-dependent modulation of ultrasound speed in articular cartilage under dynamic compression

Lötjönen P, Julkunen P, Töyräs J, Lammi MJ, Jurvelin JS, Nieminen HJ. ULTRASOUND IN MEDICINE AND BIOLOGY 35 7: 1177-1184. 2009

Recent Developments and Future Prospects in Bone Ultrasound Diagnostics

Karjalainen JP., Riekkinen O., Töyräs J., Jurvelin JS., Kröger H.. European Musculoskeletal Review 3 2: 90-94. 2008

A portable device for intensive care brain function monitoring with event-related potentials

Tiihonen P, Kinnunen J, Töyräs J, Mervaala E, Pääkkönen A. COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE 89: 83-92. 2008

Dual-frequency ultrasound - new pulse-echo technique for bone densitometry

Riekkinen O, Hakulinen MA, Töyräs J, Jurvelin JS. ULTRASOUND IN MEDICINE AND BIOLOGY 34 10: 1703-1708. 2008

Indentation diagnostics of cartilage degeneration

Kiviranta P, Lammentausta E, Töyräs J, Kiviranta I, Jurvelin JS. OSTEOARTHRITIS AND CARTILAGE 16: 796-804. 2008

The zonal architecture of human articular cartilage described by T2 relaxation time in the presence of Gd-DTPA2-

Kurkijärvi JE, Nissi MJ, Rieppo J, Töyräs J, Kiviranta I, Nieminen MT, Jurvelin JS. MAGNETIC RESONANCE IMAGING 26: 602-607. 2008

Dual-frequency ultrasound technique minimizes errors induced by soft tissue in ultrasound bone densitometry

Karjalainen J, Töyräs J, Rikkonen T, Jurvelin JS, Riekkinen O. ACTA RADIOLOGICA 49 9: 1038-1041. 2008

Recent developments and future prospects in bone ultrasound diagnostics

Karjalainen J, Riekkinen O, Töyräs J, Jurvelin J, Kröger H. , European Musculoskeletal Review [Online].Touch Briefings. 87-89. 2008

Dual frequency ultrasound technique minimizes errors induced by soft tissues in ultrasound bone densitometry

Janne Karjalainen, Juha Töyräs, Toni Rikkonen, Jukka Jurvelin, Ossi Riekkinen. ACTA RADIOLOGICA 49: 1038-41. 2008

In-vitro comparison of time-domain, frequency-domain and wavelet ultrasound parameters in diagnostics of cartilage degeneration

Kaleva E, Saarakkala S, Töyräs J, Nieminen HJ, Jurvelin JS. ULTRASOUND IN MEDICINE AND BIOLOGY 34: 155-159. 2008

Fysikaaliset ja kemialliset menetelmät nivelrikon varhaisessa osoittamisessa

Jurvelin JS, Nieminen MT, Töyräs J, Risteli J, Laasanen MS, Konttinen YT, Kiviranta I. DUODECIM 124: 1885-1896. 2008

Ultrasonic assessment of cortical bone thickness In Vitro and In Vivo

Karjalainen J, Riekkinen O, Töyräs J, Kröger H, Jurvelin J. IEEE TRANSACTIONS ON ULTRASONICS, FERROELECTRICS, AND FREQUENCY CONTROL 55 10: 2191-2197. 2008

Acoustic properties of trabecular bone-relationships to tissue composition

Riekkinen O, Hakulinen MA, Lammi MJ, Jurvelin JS, Kallioniemi A, Töyräs J. ULTRASOUND IN MEDICINE AND BIOLOGY 33 9: 1438-1444. 2007

Effect of human trabecular bone composition on its electrical properties

Sierpowska J, Lammi MJ, Hakulinen MA, Jurvelin JS, Lappalainen R, Töyräs J. MEDICAL ENGINEERING & PHYSICS 29 8: 845-852. 2007

Quantitative information from ultrasound evaluation of articular cartilage should be interpreted with care

Saarakkala S, Jurvelin JS, Zheng YP, Nieminen HJ, Töyräs J. ARTHROSCOPY 23 10: 1137-1141. 2007

Spatial variation of acoustic properties is related with mechanical properties of trabecular bone

Riekkinen O, Hakulinen MA, Töyräs J, Jurvelin JS. PHYSICS IN MEDICINE AND BIOLOGY 52: 6961-6968. 2007

Ultrasound speed in articular cartilage under mechanical compression

Nieminen HJ, Julkunen P, Töyräs J, Jurvelin JS. ULTRASOUND IN MEDICINE AND BIOLOGY 33 11: 1755-1766. 2007

Human articular cartilage proteoglycans are not undesulfated in osteoarthritis

Qu CJ, Rieppo J, Hyttinen MM, Lammi MJ, Kiviranta I, Kurkijärvi J, Jurvelin J, Töyräs J. CONNECTIVE TISSUE RESEARCH 48 1: 27-33. 2007

Estimation of mechanical properties of articular cartilage with MRI - dGEMRIC, T2 and T1 imaging in different species with variable stages of maturation

Nissi MJ, Rieppo J, Töyräs J, Laasanen MS, Kiviranta I, Nieminen MT, Jurvelin JS. OSTEOARTHRITIS AND CARTILAGE 15: 1141-1148. 2007

Quantitative MRI of parallel changes of articular cartilage and underlying trabecular bone in degeneration

Lammentausta E, Kiviranta P, Töyräs, Hyttinen MM, Kiviranta I, Nieminen MT, Jurvelin JS. Osteoarthritis and cartilage 15: 1149-1157. 2007

Comparison of novel clinically applicable methodology for sensitive diagnostics of cartilage degeneration

Kiviranta P, Töyräs J, Nieminen MT, Laasanen MS, Saarakkala S, Nieminen HJ, Nissi MJ, Jurvelin J. European cells and materials 13: 46-55. 2007

Contrast agent enhanced pQCT of articular cartilage

Kallioniemi AS, Jurvelin JS, Nieminen MT, Lammi MJ, Töyräs J. PHYSICS IN MEDICINE AND BIOLOGY 52: 1209-1219. 2007

T2 relaxation time mapping reveals age- and species-related diversity of collagen network architecture in articular cartilage

Nissi MJ, Rieppo J, Töyräs J, Laasanen MS, Kiviranta I, Jurvelin JS, Nieminen MT. OSTEOARTHRITIS AND CARTILAGE 14: 1265-1271. 2006

Quantitative ultrasound imaging detects degenerative changes in articulas cartilage surface and subchondral bone

Saarakkala S, Laasanen MS, Jurvelin JS, Töyräs J. PHYSICS IN MEDICINE AND BIOLOGY 51: 5333-5346. 2006

Influence of overlying soft tissues on trabecular bone acoustic measurement at various ultrasound frequencies

Riekkinen O, Hakulinen MA, Timonen M, Töyräs J, Jurvelin JS. ULTRASOUND IN MEDICINE AND BIOLOGY 32 7: 1073-1083. 2006

Interrelationships between electrical proberties and microstructure of human trabecular bone

Sierpowska J, Hakulinen MA, Töyräs J, Day JS, Weinans H, Kiviranta I, Jurvelin JS, Lappalainen R. PHYSICS IN MEDICINE AND BIOLOGY 51: 5289-5303. 2006

Acoustic properties articular cartilage under mechanical stress

Nieminen HJ, Töyräs J, Laasanen MS, Jurvelin JS. BIORHEOLOGY 43 3-4: 523-535. 2006

Ultrasound stimulates proteoglycan synthesis in bovine primary chondrocytes

Kopakkala-Tani M, Leskinen JJ, Karjalainen HM, Karjalainen T, Hynynen K, Töyräs J, Jurvelin JS, Lammi MJ. BIORHEOLOGY 43: 271-282. 2006

Collagen network primarily controls Poisson's ratio of bovine articular cartilage in compression

Kiviranta P, Rieppo J, Korhonen RK, Julkunen P, Töyräs J, Jurvelin JS. JOURNAL OF ORTHOPAEDIC RESEARCH 24 4: 690-699. 2006

Ultrasonic characterization of human trabecular bone microstructure

Hakulinen MA, Day JS, Töyräs J, Weinans H, Jurvelin JS, Hakulinen MA. PHYSICS IN MEDICINE AND BIOLOGY 51: 1633-1648. 2006

Quantitative ultrasound imaging of spontaneous repair of porcine cartilage

Laasanen MS, Töyräs J, Vasara A, Saarakkala S, Hyttinen MM, Kiviranta I, Jurvelin JS. OSTEOARTHRITIS AND CARTILAGE 14: 258-263. 2006

Prediction of density and mechanical properties of human trabecular bone in vitro by using ultrasound transmission and backscattering measurements at 0.2-6.7 MHz frequency range

Hakulinen MA, Day JS, Töyräs J, Timonen M, Kröger H, Weinans H, Kiviranta I, Jurvelin JS, Kröger H. PHYSICS IN MEDICINE AND BIOLOGY 50: 1629-1642. 2005

Site-specific ultrasound reflection properties and superficial collagen content of bovine knee articular cartilage

Laasanen MS, Saarakkala S, Töyräs J, Rieppo J, Jurvelin JS. PHYSICS IN MEDICINE AND BIOLOGY 50: 3221-3233. 2005

Prediction of mechanical properties of human trabecular bone by electrical measurements

Sierpowska J, Hakulinen MA, Töyräs J, Day JS, Weinans H, Jurvelin JS, Lappalainen R. PHYSIOLOGICAL MEASUREMENT 26: S119-S131. 2005

Improvement of arthroscopic cartilage stiffness probe using amorphous diamond coating

Töyräs J, Korhonen RK, Voutilainen T, Jurvelin JS, Lappalainen R. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH B. APPLIED BIOMATERIALS 73B: 15-22. 2005

Proteoglycan and collagen sensitive MRI evaluation of normal and degenerated articular cartilage

Nissi MJ, Töyräs J, Laasanen MS, Rieppo J, Saarakkala S, Lappalainen R, Jurvelin JS, Nieminen MT. JOURNAL OF ORTHOPAEDIC RESEARCH 22: 557-564. 2004

Ultrasonic quantitation of superficial degradation of articular cartilage

Saarakkala S, Töyräs J, Hirvonen J, Laasanen MS, Lappalainen R, Jurvelin JS. ULTRASOUND IN MEDICINE AND BIOLOGY 30 6: 783-792. 2004

Mechano-acoustic determination of Young's moduls of articular cartilage

Saarakkala S, Korhonen RK, Laasanen MS, Töyräs J, Rieppo J, Jurvelin JS. BIORHEOLOGY 41: 167-179. 2004

Undersulfated chondroitin sulfate does not increase in osteoarthritic cartilage

Lammi MJ, Qu C-J, Laasanen MS, Saarakkala S, Rieppo J, Jurvelin JS, Töyräs J. JOURNAL OF RHEUMATOLOGY 31: 2449-2453. 2004

Prediction of biomechanical properties of articular cartilage with quantitative magnetic resonance imaging

Nieminen MT, Töyräs J, Laasanen MS, Silvennoinen J, Helminen HJ, Jurvelin JS. JOURNAL OF BIOMECHANICS 37: 321-328. 2004

Ultrasound attenuation in normal and spontaneously degenerated articular cartilage

Nieminen HJ, Saarakkala S, Laasanen MS, Hirvonen J, Jurvelin JS, Töyräs J. ULTRASOUND IN MEDICINE AND BIOLOGY 30 4: 493-500. 2004

Ability of ultrasound backscattering to predict mechanical properties of bovine trabecular bone

Hakulinen MA, Töyräs J, Saarakkala S, Hirvonen J, Kröger H, Jurvelin JS, Kröger H. ULTRASOUND IN MEDICINE AND BIOLOGY 30 7: 919-927. 2004

Speed of sound in normal and degenerated bovine articular cartilage

Töyräs J, Laasanen MS, Saarakkala S, Lammi MJ, Rieppo J, Kurkijärvi J, Lappalainen R, Jurvelin JS. ULTRASOUND IN MEDICINE AND BIOLOGY 29 3: 447-454. 2003

Electrical and dielectric properties of bovine trabecular bone - relationship with mechanical properties and mineral density

Sierpowska J, Töyräs J, Hakulinen MA, Saarakkala S, Jurvelin JS, Lappalainen R. PHYSICS IN MEDICINE AND BIOLOGY 48: 775-786. 2003

Ultrasound indentation of normal and spontaneously degenerated bovine articular cartilage

Saarakkala S, Laasanen MS, Jurvelin JS, Törrönen K, Lammi MJ, Lappalainen R, Töyräs J. OSTEOARTHRITIS AND CARTILAGE 11: 697-705. 2003

Structure-function relationships in enzymatically modified articular cartilage

Rieppo J, Töyräs J, Nieminen MT, Kovanen V, Hyttinen MM, Korhonen RK, Jurvelin JS, Helminen HJ. CELLS TISSUES ORGANS 175: 121-132. 2003

Biomechanical properties of knee articular cartilage

Laasanen MS, Töyräs J, Korhonen RK, Rieppo J, Saarakkala S, Nieminen MT, Hirvonen J, Jurvelin JS. BIORHEOLOGY 40: 133-140. 2003

Mechano-acoustic diagnosis of cartilage degeneration and repair

Laasanen MS, Töyräs J, Vasara AI, Hyttinen MM, Saarakkala S, Hirvonen J, Jurvelin JS, Kiviranta I. JOURNAL OF BONE AND JOINT SURGERY (AM) SUPPLEMENT 85-A 2: 78-84. 2003

Experimental and numerical validation for the novel configuration of an arthroscopic indentation instrument

Korhonen RK, Saarakkala S, Töyräs J, Laasanen MS, Kiviranta I, Jurvelin JS. PHYSICS IN MEDICINE AND BIOLOGY 48: 1565-1576. 2003

Fibril reinforced poroelastic model predicts specifically mechanical behavior of normal, proteoglycan depleted and collagen degraded articular cartilage

Korhonen RK, Laasanen MS, Töyräs J, Lappalainen R, Helminen HJ, Jurvelin JS. JOURNAL OF BIOMECHANICS 36: 1373-1379. 2003

Dual energy x-ray laser measurement of calcaneal bone mineral density

Hakulinen MA, Saarakkala S, Töyräs J, Kröger H, Jurvelin JS. PHYSICS IN MEDICINE AND BIOLOGY 48: 1741-1752. 2003

Ultrasound indentation of bovine knee articular cartilage in situ

Laasanen MS, Saarakkala S, Töyräs J, Hirvonen J, Rieppo J, Korhonen RK, Jurvelin JS. JOURNAL OF BIOMECHANICS 36: 1259-1267. 2003

Spatial assessment of articular cartilage proteoglycans with Gd-DTPA-enhanced T1 imaging

Nieminen MT, Rieppo J, Silvennoinen J, Töyräs J, Hakumäki JM, Hyttinen MM, Helminen HJ, Jurvelin JS. MAGNETIC RESONANCE IN MEDICINE 48: 640-648. 2002

Ultrasonic characterization of articular cartilage

Töyräs J, Nieminen HJ, Laasanen MS, Nieminen MT, Korhonen RK, Rieppo J, Hirvonen J, Helminen HJ, Jurvelin JS. BIORHEOLOGY 39 1,2: 161-169. 2002

Bone mineral density, ultrasound velocity, and broadband attenuation predict mechanical properties of trabecular bone differently

Töyräs J, Nieminen MT, Kröger H, Jurvelin JS. BONE 31 4: 503-507. 2002

Real-time ultrasound analysis of articular cartilage degradation in vitro

Nieminen HJ, Töyräs J, Rieppo J, Nieminen MT, Hirvonen J, Korhonen R, Jurvelin JS. ULTRASOUND IN MEDICINE AND BIOLOGY 28 4: 519-525. 2002

Novel mechano-acoustic technigue and instrument for diagnosis of cartilage degeneration

Laasanen MS, Töyräs J, Hirvonen J, Saarakkala S, Korhonen RK, Nieminen MT, Kiviranta I, Jurvelin JS. PHYSIOLOGICAL MEASUREMENT 23: 491-503. 2002

Comparison of the equilibrium response of articular cartilage in unconfined compression, confined compression and indentation

Korhonen RK, Laasanen MS, Töyräs J, Rieppo J, Hirvonen J, Helminen HJ, Jurvelin JS. JOURNAL OF BIOMECHANICS 35: 903-909. 2002

Inactivation of one allele of the type II collagen gene alters the collagen network in murine articular cartilage and makes cartilage softer

Hyttinen MM, Töyräs J, Lapveteläinen T, Lindblom J, Prockop DJ, Li S-W, Arita M, Jurvelin JS, Helminen HJ. ANNALS OF THE RHEUMATIC DISEASES 60: 262-268. 2001

Development of arthroscopic indentation technique for the diagnosis of cartilage degeneration

Lyyra-Laitinen T, Töyräs J, Kiviranta I, Jurvelin JS. Kotila S, Haataja J, CSC Report on Scientific Computing 1999-2000.CSC - Scientific Computing. 181-184. 2001

T2 Relaxation reveals spatial collagen architecture in articular cartilage: a comparative quantitative MRI and polarized light microscopic study

Nieminen MT, Rieppo J, Töyräs J, Hakumäki JM, Silvennoinen J, Hyttinen MM, Helminen HJ, Jurvelin JS. MAGNETIC RESONANCE IN MEDICINE 46: 487-493. 2001

Estimation of the Young's modulus of articular cartilage using an arthroscopic indentation instrument and ultrasonic measurement of tissue thickness

Töyräs J, Lyyra-Laitinen T, Niinimäki M, Lindgren R, Nieminen MT, Kiviranta I, Jurvelin JS. JOURNAL OF BIOMECHANICS 34: 251-256. 2001

Mechano-Acoustic Characterization of Articular Cartilage and Trabecular Bone

Töyräs J. Kuopion yliopiston julkaisuja C. Luonnontieteet ja ympäristötieteet. 2001

Quantitative MR microscopy of enzymatically degraded articular cartilage

Nieminen MT, Töyräs J, Rieppo J, Hakumäki JM, Silvennoinen J, Helminen HJ, Jurvelin JS. MAGNETIC RESONANCE IN MEDICINE 43: 676-681. 2000

Optimization of the arthroscopic indentation instrument for the measurement of thin cartilage stiffness

Lyyra-Laitinen T, Niinimäki M, Töyräs J, Lindgren R, Kiviranta I, Jurvelin JS. PHYSICS IN MEDICINE AND BIOLOGY 44: 2511-2524. 1999

Bone properties as estimated by mineral density, ultrasound attenuation, and velocity

Töyräs J, Kröger H, Jurvelin JS. BONE 25 6: 725-731. 1999

Characterization of enzymatically induced degradation of articular cartilage using high frequency ultrasound

Töyräs J, Rieppo J, Nieminen MT, Helminen HJ, Jurvelin JS. PHYSICS IN MEDICINE AND BIOLOGY 44: 2723-2733. 1999

Tutkimusryhmät

Gamma Power of Electroencephalogram Arousal is Modulated by Respiratory Event Type and Severity in Obstructive Sleep Apnea

Quantitative dual contrast photon-counting computed tomography for assessment of articular cartilage health

Characterization of connective tissues using near-infrared spectroscopy and imaging

Infrared Fiber-Optic Spectroscopy Detects Bovine Articular Cartilage Degeneration

The effect of subchondral bone plate thickness and trabecular bone volume fraction on the mechanical behavior of cartilage in post-traumatic osteoarthritis

Raman spectroscopy is sensitive to biochemical changes related to various cartilage injuries

Dual-contrast computed tomography enables detection of equine posttraumatic osteoarthritis in vitro

An In-Laboratory Comparison of FocusBand EEG Device and Textile Electrodes Against a Medical-Grade System and Wet Gel Electrodes

Technical Performance of Textile-Based Dry Forehead Electrodes Compared With Medical-Grade Overnight Home Sleep Recordings

Biomechanical, biochemical, and near infrared spectral data of bovine knee ligaments and patellar tendon

Structure, composition and fibril-reinforced poroviscoelastic properties of bovine knee ligaments and patellar tendon

Total durations of respiratory events are modulated within REM and NREM sleep by sleeping position and obesity in OSA patients

Machine learning augmented near-infrared spectroscopy: In vivo follow-up of cartilage defects

Functional and Structural Properties of Human Patellar Articular Cartilage in Osteoarthritis

Longer and Deeper Desaturations Are Associated With the Worsening of Mild Sleep Apnea: The Sleep Heart Health Study

Automatic Respiratory Event Scoring in Obstructive Sleep Apnea Using a Long Short-Term Memory Neural Network

Subject-specific biomechanical analysis to estimate locations susceptible to osteoarthritis - Finite element modeling and MRI follow-up of ACL reconstructed patients

Assessment of Obstructive Sleep Apnea-Related Sleep Fragmentation Utilizing Deep Learning-Based Sleep Staging from Photoplethysmography

Auttaako teknologia uniongelmiin?

Diabetes and cardiovascular diseases are associated with the worsening of intermittent hypoxaemia

Articular cartilage optical properties in the near-infrared (NIR) spectral range vary with depth and tissue integrity

Detailed assessment of sleep architecture with deep learning and shorter epoch-to-epoch duration reveals sleep fragmentation of patients with obstructive sleep apnea

Self-Applied Home Sleep Recordings: The Future of Sleep Medicine

Neural network analysis of nocturnal SpO2 signal enables easy screening of sleep apnea in patients with acute cerebrovascular disease

Beyond the apnea-hypopnea index: alternative diagnostic parameters and machine learning solutions for estimation of sleep apnea severity

Discrete element and finite element methods provide similar estimations for hip joint contact mechanics during walking gait

Estimating daytime sleepiness with previous night EEG, EOG and EMG spectrograms in patients with suspected sleep apnea using a convolutional neural network

Mid-infrared and Near infrared spectroscopic analysis of mechanically and enzymatically damaged cartilage

Mid-infrared spectroscopic assessment of cartilage degeneration

Rapid CT-based Estimation of Articular Cartilage Biomechanics in the Knee Joint Without Cartilage Segmentation

Clinical Contrast-enhanced Computed Tomography with Semiautomatic Segmentation Provides Feasible Input for Computational Models of the Knee Joint

Tailored Synthesis of PEGylated Bismuth Nanoparticles for X-ray Computed Tomography and Photothermal Therapy: One-Pot, Targeted Pyrolysis, and Self-Promotion

Near Infrared Spectroscopy Enables Differentiation of Mechanically and Enzymatically Induced Cartilage Injuries

Bright ultra-short echo time SWIFT MRI signal at the osteochondral junction is not located in the calcified cartilage

Optical properties of articular cartilage in the near-infrared spectral range are related to its proteoglycan content

Comparison of water, hydroxyproline, uronic acid and elastin contents of bovine knee ligaments and patellar tendon and their relationships with biomechanical properties

Structural, compositional, and functional effects of blunt and sharp cartilage damage on the joint: a 9-month equine groove model study

Open-source python module for automated preprocessing of near infrared spectroscopic data

Acute stroke and TIA patients have specific polygraphic features of obstructive sleep apnea

Polysomnographic characteristics of severe obstructive sleep apnea vary significantly between hypertensive and normotensive patients of both genders

Quantification of Myocardial Blood Flow by Machine Learning Analysis of Modified Dual Bolus MRI Examination

Comparison of the effect of weight change, simulated computational continuous positive airway pressure treatment and positional therapy on severity of sleep apnea

Longer duration electroencephalogram arousals have a better relationship with impaired vigilance and health status in obstructive sleep apnoea

Machine Learning Classification of Articular Cartilage Integrity Using Near Infrared Spectroscopy

Near-Infrared Spectroscopy for Mapping of Human Meniscus Biochemical Constituents

Automated Preprocessing of Near Infrared Spectroscopic Data

Deep learning enables sleep staging from photoplethysmogram for patients with suspected sleep apnea

Dual Contrast in Computed Tomography Allows Earlier Characterization of Articular Cartilage over Single Contrast

Identification of locations susceptible to osteoarthritis in patients with anterior cruciate ligament reconstruction: Combining knee joint computational modelling with follow-up T1p and T2 imaging

Effects of Human Articular Cartilage Constituents on Simultaneous Diffusion of Cationic and Non-ionic Contrast Agents

Longer apneas and hypopneas are associated with greater ultra-short-term HRV in obstructive sleep apnea

Tissue optical properties combined with machine learning enables estimation of articular cartilage composition and functional integrity

Severe Desaturations Increase PVT-based Median Reaction Time and Number of Lapses in OSA Patients

Increased nocturnal arterial pulsation frequencies of obstructive sleep apnoea patients is associated with an increased number of lapses in a psychomotor vigilance task

Power spectral densities of nocturnal pulse oximetry signals differ in OSA patients with and without daytime sleepiness

Evaluation of articular cartilage with quantitative MRI in an equine model of post-traumatic osteoarthritis

Effect of sweating on electrode-skin contact impedances and artifacts in EEG recordings with various screen-printed Ag/Agcl electrodes

Prevalence and characteristics of positional obstructive sleep apnea (POSA) in patients with severe OSA

Artificial neural network analysis of the oxygen saturation signal enables accurate diagnostics of sleep apnea

Intra-night variation in apnea-hypopnea index affects diagnostics and prognostics of obstructive sleep apnea

T2* and quantitative susceptibility mapping in an equine model of post-traumatic osteoarthritis: assessment of mechanical and structural properties of articular cartilage

Simultaneous Quantitation of Cationic and Non-ionic Contrast Agents in Articular Cartilage Using Synchrotron MicroCT Imaging

Near infrared spectroscopy enables quantitative evaluation of human cartilage biomechanical properties during arthroscopy

Arthroscopic Determination of Cartilage Proteoglycan Content and Collagen Network Structure with Near-Infrared Spectroscopy

Dataset on equine cartilage near infrared spectra, composition, and functional properties

Polysomnographic scoring of sleep bruxism events is accurate even in the absence of video recording but unreliable with EMG-only setups

Computational evaluation of altered biomechanics related to articular cartilage lesions observed in vivo

Does Magnetic Resonance Imaging Provide Superior Reliability for Achilles and Patellar Tendon Cross-Sectional Area Measurements Compared with Ultrasound Imaging?

Effects of body mass on microstructural features of the osteochondral unit: A comparative analysis of 37 mammalian species

Triple Contrast CT Method Enables Simultaneous Evaluation of Articular Cartilage Composition and Segmentation

The hypoxic burden: also known as the desaturation severity parameter

Imaging of Proteoglycan and Water Contents in Human Articular Cartilage with Full-Body CT Using Dual Contrast Technique

Synchrotron microCT reveals the potential of the dual contrast technique for quantitative assessment of human articular cartilage composition

Contrast enhanced computed tomography for real-time quantification of glycosaminoglycans in cartilage tissue engineered constructs

Quantification of porcine myocardial perfusion with modified dual bolus MRI - a prospective study with a PET reference

Severity of desaturations reflects OSA-related daytime sleepiness better than AHI

Improved Sweat Artifact Tolerance of Screen-Printed EEG Electrodes by Material Selection-Comparison of Electrochemical Properties in Artificial Sweat

Mortality-risk-based apnea-hypopnea index thresholds for diagnostics of obstructive sleep apnea