Jussi Pihlajamäki

Dongiovanni, P; Meroni, M; Baselli, GA; Mancina, RM; Ruscica, M; Longo, M; Rametta, R; Cespiati, A; Pelusi, S; Ferri, N; Ranzani, V; Nobili, V; Pihlajamaki, J; Fracanzani, AL; Badiali, S; Petta, S; Fargion, S; Romeo, S; Kozlitina, J; Valenti, L. 2019. PCSK7 gene variation bridges atherogenic dyslipidemia with hepatic inflammation in NAFLD patients Journal of lipid research 60 6: 1144-1153. 2019

Pelusi, S; Cespiati, A; Rametta, R; Pennisi, G; Mannisto, V; Rosso, C; Baselli, G; Dongiovanni, P; Fracanzani, AL; Badiali, S; Maggioni, M; Craxi, A; Fargion, S; Prati, D; Nobili, V; Bugianesi, E; Romeo, S; Pihlajamaki, J; Petta, S; Valenti, L. 2019. Prevalence and Risk Factors if Significant Fibrosis in Patients With Nonalcoholic Fatty Liver Without Steatohepatitis Clinical gastroenterology and hepatology in press, accepted manuscript: -. 2019

Walle, P; Männistö, V; de Mello, VD; Vaittinen, M; Perfilyev, A; Hanhineva, K; Ling, C; Pihlajamäki, J. 2019. Liver DNA methylation of FADS2 associates with FADS2 genotypex Clinical epigenetics 11 1: 10. 2019

Puris, E; Pasanen, M; Ranta, VP; Gynther, M; Petsalo, A; Käkelä, P; Männistö, V; Pihlajamäki, J. 2019. Laparoscopic Roux-en-Y gastric bypass surgery influenced pharmacokinetics of several drugs given as a cocktail with the highest impact observed for CYP1A2, CYP2C8 and CYP2E1 substrates Basic and clinical pharmacology and toxicology 125 2: 123-132. 2019

Pihlajamäki, J; Männikkö, R; Tilles-Tirkkonen, T; Karhunen, L; Kolehmainen, M; Schwab, U; Lintu, N; Paananen, J; Järvenpää, R; Harjumaa, M; Martikainen, J; Kohl, J; Poutanen, K; Ermes, M; Absetz, P; Lindström, J; Lakka, TA. 2019. Digitally supported program for type 2 diabetes risk identification and risk reduction in real-world setting: protocol for the StopDia model and randomized controlled trial Bmc public health 19: 255. 2019

Keski-Rahkonen, Pekka; Kolehmainen, Marjukka; Lappi, Jenni; Micard, Valerie; Jokkala, Jenna; Rosa-Sibakov, Natalia; Pihlajamäki, Jussi; Kirjavainen, Pirkka V; Mykkänen, Hannu; Poutanen, Kaisa; Gunter, Marc J; Scalbert, Augustin; Hanhineva, Kati. 2019. Decreased plasma serotonin and other metabolite changes in healthy adults after consumption of wholegrain rye: an untargeted metabolomics study American journal of clinical nutrition 109 6: 1630-1639. 2019

Olubamwo, OO; Virtanen, JK; Pihlajamaki, J; Tuomainen, TP. 2019. Association of fatty liver index with risk of incident type 2 diabetes by metabolic syndrome status in an Eastern Finland male cohort: a prospective study BMJ open 9 7: e026949. 2019

Lankinen, MA; Fauland, A; Shimizu, BI; Ågren, J; Wheelock, CE; Laakso, M; Schwab, U; Pihlajamäki, J. 2019. Inflammatory response to dietary linoleic acid depends on FADS1 genotype American journal of clinical nutrition 109 1: 165-175. 2019

Olubamwo, Olubunmi O; Virtanen, Jyrki K; Pihlajamäki, Jussi; Tuomainen, Tomi-Pekka. 2019. Association of fatty liver disease with mortality outcomes in an Eastern Finland male cohort BMJ open gastroenterology 6 1: e000219. 2019

Myhrstad, MC; de Mello, VD; Dahlman, I; Kolehmainen, M; Paananen, J; Rundblad, A; Carlberg, C; Olstad, OK; Pihlajamäki, J; Holven, KB; Hermansen, K; Dragsted, LO; Gunnarsdottir, I; Cloetens, L; Storm, MU; Åkesson, B; Rosqvist, F; Hukkanen, J; et al. (incl. Schwab, U; Uusitupa, M). 2019. Healthy Nordic Diet Modulates the Expression of Genes Related to Mitochondrial Function and Immune Response in Peripheral Blood Mononuclear Cells from Subjects with the Metabolic Syndrome - A SYSDIET Sub-Study Molecular nutrition and food research 63 13: 1801405. 2019

Männistö, V; Kaminska, D; Kärjä, V; Tiainen, M; de Mello, VD; Hanhineva, K; Soininen, P; Ala-Korpela, M; Pihlajamäki, J. 2019. Total liver phosphatidylcholine content associates with non-alcoholic steatohepatitis and glycine N-methyltransferase expression Liver international [Epub ahead of print 8 July 2019]: 1-11. 2019

Pyykkö, OT; Nerg, O; Niskasaari, HM; Niskasaari, T; Koivisto, AM; Hiltunen, M; Pihlajamäki, J; Rauramaa, T; Kojoukhova, M; Alafuzoff, I; Soininen, H; Jääskeläinen, JE; Leinonen, V. 2018. Incidence, comorbidities, and mortality in idiopathic normal pressure hydrocephalus. WORLD NEUROSURGERY 112: e624-e631. 2018

Tuomainen, Marjo; Lindström, Jaana; Lehtonen, Marko; Auriola, Seppo; Pihlajamäki, Jussi; Peltonen, Markku; Tuomilehto, Jaakko; Uusitupa, Matti; de Mello, Vanessa D; Hanhineva, Kati. 2018. Associations of serum indolepropionic acid, a gut microbiota metabolite, with type 2 diabetes and low-grade inflammation in high-risk individuals Nutrition and diabetes 8: 35. 2018

Tilles-Tirkkonen, Tanja; Mäki-Opas, Tomi; Vaarama, Marja; Logren, Aija; Pentikäinen, Saara; Tiitinen, Sanni; Ilomäki, Sakari; Pihlajamäki, Jussi; Laitinen, Jaana. 2018. Uudet toimintamallit hyvinvoinnin ja terveyden edistämisessä Sosiaalilääketieteellinen aikakauslehti 55 4: 364-369. 2018

Tilles-Tirkkonen, Tanja; Lappi, Jenni; Karhunen, Leila; Harjumaa, Marja; Absetz, Pilvikki; Pihlajamäki, Jussi. 2018. Sosioekonomisesti heikommassa asemassa olevien kiinnostus ja mahdollisuudet digitaalisten terveyspalveluiden käyttöön Yhteiskuntapolitiikka 83 3: 317-323. 2018

Tauriainen, Milla-Maria; Männistö, Ville; Kaminska, Dorota; Vaittinen, Maija; Kärjä, Vesa; Käkelä, Pirjo; Venesmaa, Sari; Gylling, Helena; Pihlajamäki, Jussi. 2018. Serum, liver and bile sitosterol and sitostanol in obese patients with and without NAFLD. Bioscience reports 38 2: 1-9. 2018

Roberts, SB; Das, SK; Suen, VMM; Pihlajamäki, J; Kuriyan, R; Steiner-Asiedu, M; Taetzsch, A; Anderson, AK; Silver, RE; Barger, K; Krauss, A; Karhunen, L; Zhang, X; Hambly, C; Schwab, U; Triffoni-Melo, AT; Taylor, SF; Economos, C; Kurpad, AV; Speakman, JR. 2018. Measured energy content of frequently purchased restaurant meals: multi-country cross sectional study BMJ 363: k4864. 2018

Saarti, Jarmo; Pihlajamäki, Jussi; Vanninen, Esko. 2018. Kirjasto- ja tietopalvelut on turvattava. SUOMEN LÄÄKÄRILEHTI 73 3: 117. 2018

Olubamwo, Olubamwo O; Virtanen, Jyrki K; Voutilainen, Ari; Kauhanen, Jussi; Pihlajamäki, Jussi; Tuomainen, Tomi-Pekka. 2018. Association of fatty liver index with the risk of incident cardiovascular disease and acute myocardial infarction. EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 30 9: 1047-1054. 2018

Liukkonen, MK; Mononen, ME; Vartiainen, P; Kaukinen, P; Bragge, T; Suomalainen, JS; Malo, MKH; Venesmaa, S; Käkelä, P; Pihlajamäki, J; Karjalainen, PA; Arokoski, JP; Korhonen, R. 2018. Evaluation of the effect of bariatric surgery-induced weight loss on knee gait and cartilage degeneration. JOURNAL OF BIOMECHANICAL ENGINEERING 14 4: 041008. 2018

Käkelä, Pirjo; Männistö, Ville; Vaittinen, Maija; Venesmaa, Sari; Kärjä, Vesa; Virtanen, Kirsi; Paajanen, Hannu; Pihlajamäki, Jussi. 2018. Small Intestinal Length Associates with Serum Triglycerides Before and After LRYGB Obesity surgery 28 12: 3969-3975. 2018

Järvelä-Reijonen, Elina; Karhunen, Leila; Sairanen, Essi; Muotka, Joona; Lindroos, Sanni; Laitinen, Jaana; Puttonen, Sampsa; Peuhkuri, Katri; Hallikainen, Maarit; Pihlajamäki, Jussi; Korpela, Riitta; Ermes, Miikka; Lappalainen, Raimo; Kolehmainen, Marjukka. 2018. The effects of acceptance and commitment therapy on eating behavior and diet delivered through face-to-face contact and a mobile app: a randomized controlled trial INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY 15: 22. 2018

Ihantola, EL; Viisanen, T; Gazali, AM; Näntö-Salonen, K; Juutilainen, A; Moilanen, L; Rintamäki, R; Pihlajamäki, J; Veijola, R; Toppari, J; Knip, M; Ilonen, J; Kinnunen, T. 2018. Effector T Cell Resistance to Suppression and STAT3 Signaling during the Development of Human Type 1 Diabetes JOURNAL OF IMMUNOLOGY (BALTIMORE) 201 4: 1144-1153. 2018

García-Calzón, Sonia; Perfilyev, Alexander; de Mello, Vanessa D; Pihlajamäki, Jussi; Ling, Charlotte. 2018. Sex Differences in the Methylome and Transcriptome of the Human Liver and Circulating HDL-Cholesterol Levels JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 103 12: 4395-4408. 2018

Dongiovanni, Paola; Meroni, Marica; Mancina, Rosellina M; Baselli, Guido; Rametta, Raffaela; Pelusi, Serena; Männisto, Ville; Fracanzani, Anna L; Badiali, Sara; Miele, Luca; Grimaudo, Stefania; Petta, Salvatore; Bugianesi, Elisabetta; Soardo, Giorgio; Fargion, Silvia; Pihlajamäki, Jussi; Romeo, Stefano; Valenti, Luca. 2018. Protein Phosphatase 1 Regulatory Subunit 3B Gene Variation Protects Against Hepatic Fat Accumulation and Fibrosis in Individuals at High Risk of Nonalcoholic Fatty Liver Disease Hepatology communications 2 6: 666-675. 2018

Dadson, Prince; Hannukainen, Jarna C; Din, Mueez U; Lahesmaa, Minna; Kalliokoski, Kari K; Iozzo, Patricia; Pihlajamäki, Jussi; Karlsson, Henry K; Parkkola, Riitta; Salminen, Paulina; Virtanen, Kirsi A; Nuutila, Pirjo. 2018. Brown adipose tissue lipid metabolism in morbid obesity : effect of bariatric surgery-induced weight loss DIABETES, OBESITY AND METABOLISM 20 5: 1280-1288. 2018

López Rodríguez M, Kaminska D, Lappalainen K, Pihlajamäki J, Kaikkonen MU, Laakso M. 2017. Identification and characterization of a FOXA2-regulated transcriptional enhancer at a type 2 diabetes intronic locus that controls GCKR expression in liver cells. Genome Medicine 9: 63. 2017

Walle P, Takkunen M, Männistö V, Vaittinen M, Käkelä P, Ågren J, Schwab U, Lindström J, Tuomilehto J, Uusitupa M, Pihlajamäki J. 2017. Alterations in fatty acid metabolism in response to obesity surgery combined with dietary counseling. NUTRITION AND DIABETES 7 9: e285. 2017

Viisanen T, Ihantola E-L, Näntö-Salonen K, Hyöty H, Nurminen N, Selvenius J, Juutilainen A, Moilanen L, Pihlajamäki J, Veijola R,Toppari J, Knip M, Ilonen J, Kinnunen T. 2017. Circulating CXCR5+PD-1+ICOS+ Follicular T Helper Cells Are Increased Close to the Diagnosis of Type 1 Diabetes in Children With Multiple Autoantibodi. DIABETES (NY) 66 2: 437-447. 2017

Vaittinen M, Männistö V, Käkelä P, Ågren J, Tiainen M, Schwab U, Pihlajamäki J. 2017. Interorgan cross talk between fatty acid metabolism, tissue inflammation, and FADS2 genotype in humans with obesity. OBESITY (SILVER SPRING, MD.) 25 3: 545-552. 2017

Seuter Sabine, Virtanen Jyrki K, Nurmi Tarja, Pihlajamäki Jussi, Mursu Jaakko, Voutilainen Sari, Tuomainen Tomi-Pekka, Neme Antonio, Carlberg Carsten. 2017. Molecular evaluation of vitamin D responsiveness of healthy young adults. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 174: 314-321. 2017

Peromaa-Haavisto P, Tuomilehto H, Kössi J, Virtanen J, Luostarinen M, Pihlajamäki J, Käkelä P, Victorzon M. 2017. Obstructive sleep apnea: the effect of bariatric surgery after 12 months. A prospective multicenter trial. SLEEP MEDICINE 35: 85-90. 2017

Neuvonen M, Tarkiainen EK, Tornio A, Hirvensalo P, Tapaninen T, Paile-Hyvärinen M, Itkonen MK, Holmberg MT, Kärjä V, Männistö VT, Neuvonen PJ, Pihlajamäki J, Backman JT, Niemi M. 2017. Effects of Genetic Variants on Carboxylesterase 1 Gene Expression, and Clopidogrel Pharmacokinetics and Antiplatelet Effects. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY 2018; 122 3: 341-345. 2017

de Mello VD, Matte A, Perfilyev A, Männistö V, Rönn T, Nilsson E, Käkelä P, Ling C, Pihlajamäki J. 2017. Human liver epigenetic alterations in non-alcoholic steatohepatitis are related to insulin action. Epigenetics [Epub 2017 Feb 23]: 287-295. 2017

Immonen H, Hannukainen JC, Kudomi N, Pihlajamäki J, Saunavaara V, Laine J, Salminen P, Lehtimäki T, Pham T, Iozzo P, Nuutila P. 2017. Increased Liver Fatty Acid Uptake Is Partly Reversed and Liver Fat Content Normalized After Bariatric Surgery. DIABETES CARE 2018; 41 2: 368-371. 2017

Hirvensalo, P; Tornio, A; Neuvonen, M; Tapaninen, T; Paile-Hyvärinen, M; Kärjä, V; Männistö, VT; Pihlajamäki, J; Backman, JT; Niemi, M. 2017. Comprehensive pharmacogenomic study reveals an important role of UGT1A3 in montelukast pharmacokinetics CLINICAL PHARMACOLOGY AND THERAPEUTICS 2018; 104 1: 158-168. 2017

García-Calzón Sonia, Perfilyev Alexander, Männistö Ville, de Mello Vanessa D, Nilsson Emma, Pihlajamäki Jussi, Ling Charlotte. 2017. Diabetes medication associates with DNA methylation of metformin transporter genes in the human liver. Clinical Epigenetics 9: 102. 2017

Dongiovanni P, Stender S, Pietrelli A, Mancina RM, Cespiati A, Petta S, Pelusi S, Pingitore P, Badiali S, Maggioni M, Mannisto V, Grimaudo S, Pipitone RM, Pihlajamaki J, Craxi A, Taube M, Carlsson LMS, Fargion S, Romeo S, Kozlitina J et al.. 2017. Causal relationship of hepatic fat with liver damage and insulin resistance in nonalcoholic fatty liver. JOURNAL OF INTERNAL MEDICINE 2018; 283 4: 356-370. 2017

de Mello VD, Paananen J, Lindstrom J, Lankinen MA, Shi L, Kuusisto J, Pihlajamaki J, Auriola S, Lehtonen M, Rolandsson O, Bergdahl IA, Nordin E, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Landberg R, Eriksson JG, Tuomilehto J, Hanhineva K, Uusitupa M. 2017. Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study. Scientific Reports 7: 46337. 2017

de Mello VD, Lankinen MA, Lindström J, Puupponen-Pimiä R, Laaksonen DE, Pihlajamäki J, Lehtonen M, Uusitupa M, Tuomilehto J, Kolehmainen M, Törrönen R, Hanhineva K. 2017. Fasting serum hippuric acid is elevated after bilberry (Vaccinium myrtillus) consumption and associates with improvement of fasting glucose levels and insulin secretion in persons at high risk of developing type 2 diabetes. Molecular Nutrition & Food Research 61 9: 1700019. 2017

Baumeier Christian, Saussenthaler Sophie, Kammel Anne, Jähnert Markus, Schlüter Luisa, Hesse Deike, Canouil Mickaël, Lobbens Stephane, Caiazzo Robert, Raverdy Violeta, Pattou François, Nilsson Emma, Pihlajamäki Jussi, Ling Charlotte, Froguel Philippe, Schürmann Annette, Schwenk Robert W. 2017. Hepatic DPP4 DNA Methylation Associates With Fatty Liver. DIABETES (NY) 66 1: 25 - 35. 2017

Dadson P, Ferrannini E, Landini L, Hannukainen JC, Kalliokoski KK, Vaittinen M, Honka H, Karlsson HK, Tuulari JJ, Soinio M, Salminen P, Parkkola R, Pihlajamäki J, Iozzo P, Nuutila P. 2017. Fatty acid uptake and blood flow in adipose tissue compartments of morbidly obese subjects with or without type 2 diabetes: Effects of bariatric surgery. AMERICAN JOURNAL OF PHYSIOLOGY. ENDOCRINOLOGY AND METABOLISM 313 2: E175-E182. 2017

Puris Elena, Pasanen Markku, Gynther Mikko, Häkkinen Merja R, Pihlajamäki Jussi, Keränen Tapani, Honkakoski Paavo, Raunio Hannu, Petsalo Aleksanteri. 2016. A liquid chromatography-tandem mass spectrometry analysis of nine cytochrome P450 probe drugs and their corresponding metabolites in human serum and urine. ANALYTICAL AND BIOANALYTICAL CHEMISTRY 2017; 409 1: 251-268. 2016

Walle Paula, Takkunen Markus, Männistö Ville, Vaittinen Maija, Lankinen Maria, Kärjä Vesa, Käkelä Pirjo, Ågren Jyrki, Tiainen Mika, Schwab Ursula, Kuusisto Johanna, Laakso Markku, Pihlajamäki Jussi. 2016. Fatty acid metabolism is altered in non-alcoholic steatohepatitis independent of obesity. METABOLISM 65 5: 655-666. 2016

Walenbergh SM, Houben T, Rensen SS, Bieghs V, Hendrikx T, van Gorp PJ, Oligschlaeger Y, Jeurissen ML, Gijbels MJ, Buurman WA, Vreugdenhil AC, Greve JW, Plat J1, Hofker MH, Kalhan S, Pihlajamäki J, Lindsey P, Koek GH, Shiri-Sverdlov R. 2016. Plasma cathepsin D correlates with histological classifications of fatty liver disease in adults and responds to intervention. Scientific Reports 6: 38278. 2016

Viitasalo Anna, Pihlajamäki Jussi, Paananen Jussi, Atalay Mustafa, Lindi Virpi, Lakka Timo A. 2016. Associations of TM6SF2 167K allele with liver enzymes and lipid profile in children: the PANIC Study. PEDIATRIC RESEARCH 79 5: 684-688. 2016

Viitasalo A, Eloranta A-M, Atalay M, Romeo S, Pihlajamäki J, Lakka TA. 2016. Association of MBOAT7 gene variant with plasma ALT levels in children: The PANIC study. PEDIATRIC RESEARCH 80 5: 651-655. 2016

Tuomilehto Henri, Vuorinen Ville-Pekka, Penttilä Elina, Kivimäki Marko, Vuorenmaa Markus, Venojärvi Mika, Airaksinen Olavi, Pihlajamäki Jussi. 2016. Sleep of professional athletes: Underexploited potential to improve health and performance. Journal of Sports Sciences [epub ahead of print 13 May 2016]: 1-7. 2016

Schwab U, Pihlajamäki J. 2016. Tarvitseeko terve ihminen ravintolisiä?. DUODECIM 132 24: 2329-34. 2016

Mancina Rosellina Margherita, Dongiovanni Paola, Petta Salvatore, Pingitore Piero, Meroni Marica, Rametta Raffaela, Borén Jan, Montalcini Tizian, Pujia Arturo, Wiklund Olov, Hindy George, Spagnuolo Rocco, Motta Benedetta Maria, Pipitone Rosaria Maria, Craxì Antonio, Fargion Silvia, Nobili Valerio, Käkelä Pirjo, Kärjä Vesa, Männistö Ville et al. 2016. The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent. GASTROENTEROLOGY 150 5: 1219-1230. 2016

Männistö Ville, Pihlajamäki JUssi. 2016. Rasvamaksa - entä sitten?. DUODECIM 132 18: 1707-1713. 2016

Dayeh T, Tuomi T, Almgren P, Perfilyev A, Jansson PA, de Mello VD, Pihlajamäki J, Vaag A, Groop L, Nilsson E, Ling C. 2016. DNA methylation of loci within ABCG1 and PHOSPHO1 in blood DNA is associated with future type 2 diabetes risk. Epigenetics 11 7: 482-488. 2016

Li J, Sung CY, Lee N, Ni Y, Pihlajamäki J, Panagiotou G, El-Nezami H. 2016. Probiotics modulated gut microbiota suppresses hepatocellular carcinoma growth in mice. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 113 9: E1306-E1315. 2016

Bysani M, Perfilyev A, de Mello VD, Rönn T, Nilsson E, Pihlajamäki J, Ling C. 2016. Epigenetic alterations in blood mirror age-associated DNA methylation and gene expression changes in human liver. Epigenomics 2017; 9 2: 105-122. 2016

Kaminska Dorota, Käkelä Pirjo, Nikkola Elina, Venesmaa Sari, Ilves Imre, Herzig Karl-Heinz, Kolehmainen Marjukka, Karhunen Leila, Kuusisto Johanna, Gylling Helena, Pajukanta Päivi, Laakso Markku, Pihlajamäki Jussi. 2016. Regulation of alternative splicing in human obesity loci. OBESITY (SILVER SPRING, MD.) 24 10: 2033-2037. 2016

Järvelä-Reijonen E, Karhunen L, Sairanen E, Rantala S, Laitinen J, Puttonen S, Peuhkuri K, Hallikainen M, Juvonen K, Myllymäki T, Föhr T, Pihlajamäki J, Korpela R, Ermes M, Lappalainen R, Kolehmainen M. 2016. High perceived stress is associated with unfavorable eating behavior in overweight and obese Finns of working age. APPETITE 103: 249-258. 2016

Käkelä P, Männistö V, Ilves I, Vaittinen M, Tauriainen MM, Eskelinen M, Gylling H, Paajanen H, Pihlajamäki J. 2016. Serum plant sterols associate with Gallstone disease independent of weight loss and non-alcoholic fatty liver disease. OBESITY SURGERY 27 5: 1284-1291. 2016

Pihlajamäki Jussi, Schwab Ursula, Kaminska Dorota, Ågren Jyrki, Kuusisto Johanna, Kolehmainen Marjukka, Paananen Jussi, Laakso Markku, Uusitupa Matti. 2015. Dietary polyunsaturated fatty acids and the Pro12Ala polymorphisms of PPARG regulate serum lipids through divergent pathways: a randomized crossover clinical trial. Genes and Nutrition 10 6: 43. 2015

Viitasalo Anna, Mustafa Atalay, Pihlajamäki Jussi, Jääskeläinen Jarmo, Korkmaz Ayhan, Kaminska Dorota, Lindi Virpi, Lakka Timo A.. 2015. The 148 M allele of the PNPLA3 is associated with plasma irisin levels in a population sample of Caucasian children: The PANIC Study. METABOLISM 64 7: 793-796. 2015

Vaittinen Maija, Walle Paula, Kuosmanen Emmi, Männistö Ville, Käkelä Pirjo, Ågren Jyrki, Schwab Ursula, Pihlajamäki Jussi. 2015. FADS2 genotype regulates delta-6 desaturase activity and inflammation in human adipose tissue. JOURNAL OF LIPID RESEARCH 2016; 57: 56-65. 2015

Vaittinen Maija, Kolehmainen Marjukka, Rydén Mikael, Eskelinen Matti, Wabitsch Martin, Pihlajamäki Jussi, Uusitupa Matti, Pulkkinen Leena. 2015. MFAP5 is Related to Obesity-Associated Adipose Tissue and Extracellular Matrix Remodeling and Inflammation. OBESITY (SILVER SPRING, MD.) 23 7: 1371-1378. 2015

Takkunen Markus J, de Mello Vanessa D, Schwab Ursula S, Kuusisto Johanna, Vaittinen Maija, Ågren Jyrki J, Laakso Markku, Pihlajamäki Jussi, Uusitupa MI. 2015. Gene-diet interaction of a common FADS1 variant with marine polyunsaturated fatty acids for fatty acid composition in plasma and erythrocytes among men. Molecular Nutrition & Food Research 2016; 60 2: 381-389. 2015

Rantakokko Panu, Männistö Ville, Airaksinen Riikka, Koponen Jani, Viluksela Matti, Kiviranta Hannu, Pihlajamäki Jussi. 2015. Persistent organic pollutants and non-alcoholic fatty liver disease in morbidly obese patients: a cohort study. ENVIRONMENTAL HEALTH [ONLINE] 14: 79. 2015

Viitasalo A, Ågren J, Venäläinen T, Pihlajamäki J, Jääskeläinen J, Korkmaz A, Atalay M, Lakka TA. 2015. Association of plasma fatty acid composition with plasma irisin levels in normal weight and overweight/obese children. PEDIATRIC OBESITY 2015; 11 4: 299-305. 2015

Peromaa-Haavisto P, Tuomilehto H, Kössi J, Virtanen J, Luostarinen M, Pihlajamäki J, Käkelä P, Victorzon M. 2015. Prevalence of Obstructive Sleep Apnoea Among Patients Admitted for Bariatric Surgery: A Prospective Multicentre Trial. OBESITY SURGERY 2016; 26 7: 1384-1390. 2015

Lankinen Maria A, Stancáková Alena, Uusitupa Matti, Ågren Jyrki, Pihlajamäki Jussi, Kuusisto Johanna, Schwab Ursula, Laakso Markku. 2015. Plasma fatty acids as predictors of glycaemia and type 2 diabetes. DIABETOLOGIA 58 11: 2533-2544. 2015

Juvonen Kristiina R, Macierzanka Adam, Lille Martina E, Laaksonen David E, Mykkänen Hannu M, Niskanen Leo K, Pihlajamäki Jussi, Mäkelä Kari A, Mills Clare EN, Mackie Alan R, Malcolm Paul, Herzig Karl-Heinz, Poutanen Kaisa S, Karhunen Leila J. 2015. Cross-linking of sodium caseinate-structured emulsion with transglutaminase alters postprandial metabolic and appetite responses in healthy young individuals. BRITISH JOURNAL OF NUTRITION 114 3: 418-429. 2015

Hendrikx Tim, Walenbergh Sofie MA, Jeurissen Mike LJ, Houben Tom, van Gorp Patrick J, Lindsey Patrick J, Koek Ger H, Kalhan Satish, Pihlajamäki Jussi, Hofker Marten H, Shiri-Sverdlov Ronit. 2015. Plasma IL-1 receptor antagonist levels correlate with the development of non-alcoholic steatohepatitis. Biomarkers in Medicine 9 12: 1301-1309. 2015

Dongiovanni Paola, Petta Salvatore, Mannisto Ville, Mancina Rosellina Margherita, Pipitone Rosaria, Karja Vesa, Maggioni Marco, Kakela Pirjo, Wiklund Olov, Mozzi Enrico, Grimaudo Stefania, Kaminska Dorota, Rametta Raffaela, Craxi Antonio, Fargion Silvia, Nobili Valerio, Romeo Stefano, Pihlajamaki Jussi, Valenti Luca. 2015. Statin use and non-alcoholic steatohepatitis in at risk individuals. JOURNAL OF HEPATOLOGY 63 3: 705-712. 2015

de Mello VDF, Lindström J, Eriksson JG, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Pihlajamäki J, Tuomilehto J, Uusitupa M. 2015. Markers of cholesterol metabolism as biomarkers in predicting diabetes in the Finnish Diabetes Prevention Study. NUTRITION, METABOLISM AND CARDIOVASCULAR DISEASES 25 7: 635-642. 2015

Dadson Prince, Landini Linda, Helmiö Mika, Hannukainen Jarna C, Immonen Heidi, Honka Miikka-Juhani, Bucci Marco, Savisto Nina, Soinio Minna, Salminen Paulina, Parkkola Riitta, Pihlajamäki Jussi, Iozzo Patricia, Ferrannini Ele, Nuutila Pirjo. 2015. Effect of Bariatric Surgery on Adipose Tissue Glucose Metabolism in Different Depots in Patients With or Without Type 2 Diabetes. DIABETES CARE 2016; 39 2: 292-299. 2015

Nilsson Emma, Matte Ashok, Perfilyev Alexander, de Mello Vanessa D, Käkelä Pirjo, Pihlajamäki Jussi, Ling Charlotte. 2015. Epigenetic alterations in human liver from subjects with type 2 diabetes in parallel with reduced folate levels. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM [epub ahead of p rint Sep 29, 2015]: -. 2015

Männistö Ville T, Simonen Marko, Soininen Pasi, Tiainen Mika, Kangas Antti J, Kaminska Dorota, Venesmaa Sari, Käkelä Pirjo, Kärjä Vesa, Gylling Helena, Ala-Korpela Mika, Pihlajamäki Jussi. 2014. Lipoprotein Subclass Metabolism in Non-Alcoholic Steatohepatitis. JOURNAL OF LIPID RESEARCH 55: 2676-2684. 2014

Viitasalo A, Pihlajamaki J, Lindi V, Atalay M, Kaminska D, Joro R, Lakka TA. 2014. Associations of I148M variant in PNPLA3 gene with plasma ALT levels during 2-year follow-up in normal weight and overweight children: the PANIC Study. PEDIATRIC OBESITY - -[Epub ahead of print]. 2014

Takalo M, Haapasalo A, Martiskainen H, Kurkinen KM, Koivisto H, Miettinen P, Khandelwal VK, Kemppainen S, Kaminska D, Mäkinen P, Leinonen V, Pihlajamäki J, Soininen H, Laakso M, Tanila H, Hiltunen M. 2014. High-fat diet increases tau expression in the brain of T2DM and AD mice independently of peripheral metabolic status. JOURNAL OF NUTRITIONAL BIOCHEMISTRY 25 6: 634-641. 2014

Pihlajamäki Jussi. 2014. Mikä on erikoissairaanhoidon rooli lihavuuden hoidossa?. SUOMEN LÄÄKÄRILEHTI 69 10: 683. 2014

Pihlajamäki Jussi, Schwab Ursula, Aatsinki Milla. 2014. Lääketieteen ja ravitsemustieteen keinot tukevat toisiaan potilaiden hoidossa. DUODECIM 130: 2223-4. 2014

Orell-Kotikangas Helena, Antikainen Anne, Pihlajamäki Jussi. 2014. Sairaalapotilaan vajaaravitsemuksen havaitseminen ja hoito. DUODECIM 130: 2231-8. 2014

Lappalainen Raimo, Sairanen Essi, Järvelä Elina, Rantala Sanni, Korpela Riitta, Puttonen Sampsa, Kujala Urho M, Myllymäki Tero, Peuhkuri Katri, Mattila Elina, Kaipainen Kirsikka, Ahtinen Aino, Karhunen Leila, Pihlajamäki Jussi, Järnefelt Heli, Laitinen Jaana, Kutinlahti Eija, Saarelma Osmo, Ermes Miikka, Kolehmainen Marjukka. 2014. The effectiveness and applicability of different lifestyle interventions for enhancing wellbeing: the study design for a randomized controlled trial for persons with metabolic syndrome risk factors and psychological distress. BMC PUBLIC HEALTH 14 310: -. 2014

Männistö Ville T, Simonen Marko, Hyysalo Jenni, Soininen Pasi, Kangas Antti J, Kaminska Dorota, Matte Ananda K, Venesmaa Sari, Käkelä Pirjo, Kärjä Vesa, Arola Johanna, Gylling Helena, Cederberg Henna, Kuusisto Johanna, Laakso Markku, Yki-Järvinen Hannele, Ala-Korpela Mika, Pihlajamäki Jussi. 2014. Ketone body production is differentially altered in steatosis and non-alcoholic steatohepatitis in obese humans. Liver International 2015; 35 7: 1853-1861. 2014

Lappi Jenni, Mykkänen Hannu, Bach Knudsen Knud Erik, Kirjavainen Pirkka, Katina Kati, Pihlajamäki Jussi, Poutanen Kaisa, Kolehmainen Marjukka. 2014. Postprandial glucose metabolism and SCFA after consuming wholegrain rye bread and wheat bread enriched with bioprocessed rye bran in individuals with mild gastrointestinal symptoms. NUTRITION JOURNAL 13 104: -. 2014

Kolehmainen Marjukka, Ulven Stine M, Paananen Jussi, de Mello Vanessa, Schwab Ursula, Carlberg Carsten, Myhrstad Mari, Pihlajamäki Jussi, Dungner Elisabeth, Sjölin Eva, Gunnarsdottir Ingibjörg, Cloetens Lieselotte, Landin-Olsson Mona, Akesson Björn, Rosqvist Fredrik, Hukkanen Janne, Herzig Karl-Heinz, Dragsted Lars O, Savolainen Markku J, Brader Lea, Hermansen Kjeld, Risérus Ulf, Thorsdottir Inga,. 2014. Healthy Nordic diet downregulates the expression of genes involved in inflammation in subcutaneous adipose tissue in individuals with features of the metabolic syndrome. AMERICAN JOURNAL OF CLINICAL NUTRITION 101 1 (2015): 228-239. 2014

Immonen H, Hannukainen JC, Iozzo P, Soinio M, Salminen P, Saunavaara V, Borra R, Parkkola R, Mari A, Lehtimäki T, Pham T, Laine J, Kärjä V, Pihlajamäki J, Nelimarkka L, Nuutila P. 2014. Effect of bariatric surgery on liver glucose metabolism in morbidly obese diabetic and non-diabetic patients. JOURNAL OF HEPATOLOGY 60 2: 377-383. 2014

Dongiovanni Paola, Petta Salvatore, Maglio Cristina, Fracanzani Anna Ludovica, Pipitone Rosaria, Mozzi Enrico, Motta Benedetta Maria, Kaminska Dorota, Rametta Raffaela, Grimaudo Stefania, Pelusi Serena, Montalcini Tiziana, Alisi Anna, Maggioni Marco, Kärjä Vesa, Borén Jan, Käkelä Pirjo, Di Marco Vito, Xing Chao, Nobili Valerio et.al.. 2014. Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease. HEPATOLOGY Epub ahead of print: -. 2014

Aikio Mari, Elamaa Harri, Vicente David, Izzi Valerio, Kaur Inderjeet, Seppinen Lotta, Speedy Helen E, Kaminska Dorota, Kuusisto Sanna, Sormunen Raija, Heijasvaara Ritva, Jones Emma L, Muilu Mikko, Jauhiainen Matti, Pihlajamäki Jussi, Savolainen Markku J, Shoulders Carol C, Pihlajaniemi Taina. 2014. Specific collagen XVIII isoforms promote adipose tissue accrual via mechanisms determining adipocyte number and affect fat deposition. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111 30: E3043-52. 2014

de Mello Vanessa Derenji Ferreira, Pulkkinen Leena, Lalli Marianne, Kolehmainen Marjukka, Pihlajamäki Jussi, Uusitupa Matti. 2014. DNA methylation in obesity and type 2 diabetes. Annals of Medicine 46: 103-113. 2014

Käkelä P, Torpström J, Venesmaa S, Ilves I, Junnila EL, Penttinen K, Martikainen T, Gylling H, Pääkkönen M, Pihlajamäki J. 2013. Mahalaukun ohitus lihavuusleikkauksena: yhden keskuksen kymmenen vuoden kokemukset ja seurannan haasteet. DUODECIM 129 7: 756-764. 2013

Vaittinen M, Kaminska D, Käkelä P, Eskelinen M, Kolehmainen M, Pihlajamäki J, Uusitupa M, Pulkkinen L. 2013. Downregulation of CPPED1 expression improves glucose metabolism in vitro in adipocytes. DIABETES (NY) 62: 3747-3750. 2013

Simonen M, Männistö V, Leppänen J, Kaminska D, Kärjä V, Venesmaa S, Käkelä P, Kuusisto J, Gylling H, Laakso M, Pihlajamäki J. 2013. Desmosterol in human nonalcoholic steatohepatitis. HEPATOLOGY 58: 976-982. 2013

Martiskainen H, Haapasalo A, Kurkinen KM, Pihlajamäki J, Soininen H, Hiltunen M. 2013. Targeting ApoE4/ApoE receptor LRP1 in Alzheimer's disease. EXPERT OPINION ON THERAPEUTIC TARGETS 17 7: 781-794. 2013

Mahendran Y, Vangipurapu J, Cederberg H, Stancáková A, Pihlajamäki J, Soininen P, Kangas AJ, Paananen J, Civelek M, Saleem NK, Pajukanta P, Lusis AJ, Bonnycastle LL, Morken MA, Collins FS, Mohlke KL, Boehnke M, Ala-Korpela M, Kuusisto J, Laakso M. 2013. Association of ketone body levels with hyperglycemia and type 2 diabetes in 9,398 Finnish men. DIABETES (NY) 62: 3618-3626. 2013

Kaminska D, Pihlajamäki J. 2013. Regulation of alternative splicing in obesity and weight loss. Adipocyte 2 3: 143-7. 2013

Käkelä P, Jääskeläinen T, Torpström J, Ilves I, Venesmaa S, Pääkkönen M, Gylling H, Paajanen H, Uusitupa M, Pihlajamäki J. 2013. Genetic risk score does not predict the outcome of obesity surgery. OBESITY SURGERY online 2014 Jan;24(1):128-33.: -. 2013

Ahlqvist E, Osmark P, Kuulasmaa T, Pilgaard K, Omar B, Brøns C, Kotova O, Zetterqvist AV, Stancáková A, Jonsson A, Hansson O, Kuusisto J, Kieffer TJ, Tuomi T, Isomaa B, Madsbad S, Gomez MF, Poulsen P, Laakso M, Degerman E, et al. (including Pihlajamäki J). 2013. Link between GIP and osteopontin in adipose tissue and insulin resistance. DIABETES (NY) 62 6: 2088-2094. 2013

Hyysalo J, Männistö VT, Zhou Y, Arolad J, Kärjä V, Leivonen M, Juut A, Jaser N, Lallukka S, Käkelä P, Venesmaa S, Simonen M, Saltevo J, Moilanen L, Korpi-Hyövalti E, Keinänen-Kiukaanniemi S, Oksa H, Orho-Melander M, Valentik L, Fargionk S, Pihlajamäki J,Peltoneng M, Yki-Järvinena H. 2013. A population-based study on the prevalence of NASH using scores validated against liver histology. JOURNAL OF HEPATOLOGY Available online 12 December 2013: -. 2013

Cederberg H, Gylling H, Miettinen TA, Paananen J, Vangipurapu J, Pihlajamäki J, Kuulasmaa T, Stancáková A, Smith U, Kuusisto J, Laakso M. 2013. Non-cholesterol sterol levels predict hyperglycemia and conversion to type 2 diabetes in finnish men. PLOS ONE [ONLINE] 8 6: e67406. 2013

Hanhineva K, Barri T, Kolehmainen M, Pekkinen J, Pihlajamäki J, Vesterbacka A, Solano-Aguilar G, Mykkänen H, Dragsted LO, Urban JF, Poutanen K. 2013. Comparative nontargeted profiling of metabolic changes in tissues and biofluids in high-fat diet-fed Ossabaw pig. JOURNAL OF PROTEOME RESEARCH 12: 3980-3992. 2013

Kaminska D, Kuulasmaa T, Venesmaa S, Käkelä P, Vaittinen M, Pulkkinen L, Pääkkönen M, Gylling H, Laakso M, Pihlajamäki J. 2012. Adipose Tissue TCF7L2 Splicing Is Regulated by Weight Loss and Associates With Glucose and Fatty Acid Metabolism. DIABETES (NY) 61: 2807-2813. 2012

Koivukangas V, Juuti A, Salminen P, Pihlajamäki J. 2012. Lihavuuskirurgian aiheet Suomessa ristiriitaiset SUOMEN LÄÄKÄRILEHTI 67 23: 1800-1800. 2012

Paajanen, Hannu; Käkelä, Pirjo; Suuronen, Satu; Paajanen, Juuso; Juvonen, Petri; Pihlajamäki, Jussi. 2012. Impact of Obesity and Associated Diseases on Outcome After Laparoscopic Cholecystectomy. SURGICAL LAPAROSCOPY, ENDOSCOPY & PERCUTANEOUS TECHNIQUES 22 6: 509-513. 2012

Pihlajamäki J, Gylling H, Schwab U. 2012. Vaikeasti sairaan ravitsemus. DUODECIM 128 17: 1733-4. 2012

Pihlajamäki J, Kuulasmaa T, Kaminska D, Simonen M, Kärjä V, Grönlund S, Käkelä P, Pääkkönen M, Kainulainen S, Punnonen K, Kuusisto J, Gylling H, Laakso M. 2012. Serum interleukin 1 receptor antagonist as anindependent marker of non-alcoholic steatohepatitis in humans. JOURNAL OF HEPATOLOGY 56 3: 663-670. 2012

Pihlajamäki J, Lerin C, Kaminska D, Venesmaa S, Itkonen P, Boes T, Floss T, Schroeder J, Dearie F, Crunkhorn S, Burak F, Jimenez-Chillaron JC, Kuulasmaa T, Miettinen P, Park PJ, Nasser I, Zhao Z, Zhang Z, Xu Y, Wurst W et.al.. 2012. Response to Brosch et al.. Cell Metabolism 15 3: 267-269. 2012

Stancáková Alena, Civelek Mete, Saleem Niyas K, Soininen Pasi, Kangas Antti J, Cederberg Henna, Paananen Jussi, Pihlajamäki Jussi, Bonnycastle Lori L, Morken Mario A, Boehnke Michael, Pajukanta Päivi, Lusis Aldons J, Collins Francis S, Kuusisto Johanna, Ala-Korpela Mika, Laakso Markku. 2012. Hyperglycemia and a common variant of GCKR are associated with the levels of eight amino acids in 9,369 Finnish men. DIABETES (NY) 61: 1895-1902. 2012

Torpström, Jaana; Käkelä, Pirjo; Pihlajamäki, Jussi. 2012. Lihavuusleikkauksen jälkeen. DIABETES JA LÄÄKÄRI 41 1: 29-33. 2012

Simonen M, Dali-Youcef N, Kaminska D, Venesmaa S, Käkelä P, Pääkkönen M, Hallikainen M, Kolehmainen M, Uusitupa M, Moilanen L, Laakso M, Gylling H, Patti ME, Auwerx J, Pihlajamäki J. 2012. Conjugated Bile Acids Associate with Altered Rates of Glucose and Lipid Oxidation after Roux-en-Y Gastric Bypass. OBESITY SURGERY 22 9: 1473-1480. 2012

Bezy Olivier, Tran Thien T, Pihlajamäki Jussi, Suzuki Ryo, Emanuelli Brice, Winnay Jonathan, Mori Marcelo A, Haas Joel, Biddinger Sudha B, Leitges Michael, Goldfine Allison B, Patti Elizabeth, King George L, Kahn C Ronald. 2011. PKCδ regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans JOURNAL OF CLINICAL INVESTIGATION 121: 2504-2517. 2011

Karhapää P, Pihlajamäki J, Pörsti I, Kastarinen M, Mustonen J, Niemelä O, Tuomi H, Kuusisto J.. 2011. Glomerular filtration rate and parathyroid hormone are associated with 1,25-dihydroxyvitamin D in men without chronic kidney disease JOURNAL OF INTERNAL MEDICINE 2011: online. 2011

Pihlajamäki J, Kuulasmaa T, Kaminska D, Simonen M, Kärjä V, Grönlund S, Käkelä P, Pääkkönen M, Kainulainen S, Punnonen K, Kuusisto J, Gylling H, Laakso M. 2011. Serum interleukin 1 receptor antagonist as an independent marker of non-alcoholic steatohepatitis in humans JOURNAL OF HEPATOLOGY 56 3: 663-670. 2011

Pihlajamäki Jussi, Lerin Carles, Itkonen Paula, Boes Tanner, Thomas Floss Thomas, Schroeder Joshua, Dearie Farrell, Crunkhorn Sarah, Burak Furkan, Jimenez-Chillaron Josep C., Kuulasmaa Tiina, Miettinen Pekka, Park Peter J., Nasser Imad, Zhao Zhenwen, Zhang Zhaiyi, Xu Yan, Wurst Wolfgang, Ren Hongmei, Morris Andrew J.Stamm Stefan, Goldfine Allison B., Laakso Markku, Patti Mary Elizabeth. 2011. Expression of the Splicing Factor Gene SFRS10 Is Reduced in Human Obesity and Contributes to Enhanced Lipogenesis Cell Metabolism 14 2: 208-218. 2011

Vangipurapu J, Stancakova A, Pihlajamäki J, Kuulasmaa TM, Kuulasmaa T, Paananen J, Kuusisto J, Ferrannini E, Laakso M. 2011. Association of indices of liver and adipocyte insulin resistance with 19 confirmed susceptibility loci for type 2 diabetes in 6,733 non-diabetic Finnish men DIABETOLOGIA 54: 563-571. 2011

Ruotsalainen E, Stancakova A, Vauhkonen I, Salmenniemi U, Pihlajamäki J, Punnonen K, Laakso M. 2010. Changes in cytokine levels during acute hyperinsulinemia in offspring of type 2 diabetic subjects ATHEROSCLEROSIS 210: 536-541. 2010

Rutanen J, Yaluri N, Modi S, Pihlajamäki J, Vänttinen M, Itkonen P, Kainulainen S, Yamamoto H, Lagouge M, ..., Laakso M. 2010. SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity. DIABETES (NY) 59: 829-835. 2010

Pihlajamäki J, Grönlund S, Simonen M, Käkelä P, Moilanen L, Pääkkönen M, Pirinen E, Kolehmainen M, Kärjä V, Kainulainen S, Uusitupa M, Alhava E, Miettinen TA, Gylling H. 2010. Cholesterol absorption decreases after Roux-en-Y gastric bypass but not after gastric banding METABOLISM: CLINICAL AND EXPERIMENTAL 59: 866-872. 2010

Gylling H, Hallikainen M, Pihlajamaki J, Simonen P, Kuusisto J, Laakso M, Miettinen TA.. 2010. Insulin sensitivity regulates cholesterol metabolism to a greater extent than obesity. Lessons from the METSIM study.. JOURNAL OF LIPID RESEARCH 51: 2422-2427. 2010

Pirinen E, Gylling H, Itkonen P, Yaluri N, Heikkinen S, Pietilä M, Kuulasmaa T, Tusa M, Cerrada-Gimenez M, Pihlajamäki J, Alhonen L, Jänne J, Miettinen TA & Laakso M. 2010. Activated polyamine catabolism leads to low cholesterol levels by enhancing bile acid synthesis. AMINO ACIDS 38: 549-560. 2010

Karhapää P, Pihlajamäki J, Pörsti I, Kastarinen M, Mustonen J, Niemelä P, Kuusisto J. 2010. Diverse associations of 25-hydroxyvitamin D and 1,25-dihydroxy-vitamin D with dyslipidaemias. JOURNAL OF INTERNAL MEDICINE 268: 604-610. 2010

Honka M-J, Vänttinen M, Iozzo P, Virtanen KA, Lautamäki R, Hällsten K, Borra RJH, Takala T, Viljanen APM, Kemppainen J, Pihlajamäki J, Knuuti J, Nuutila P, Laakso M. 2009. The Pro12Ala polymorphism of the PPARgamma2 gene is associated with hepatic glucose uptake during hyperinsulinwmia in subjects with type 2 diabetes mellitus. METABOLISM: CLINICAL AND EXPERIMENTAL 58: 541-546. 2009

Gylling H, Hallikainen M, Rajaratnam RA, Simonen P, Pihlajamäki J, Laakso M, Miettinen TA. 2009. The metabolism of plant sterols is disturbed in postmenopausal women with coronary artery disease. METABOLISM: CLINICAL AND EXPERIMENTAL 58: 401-407. 2009

Hammerstedt A, Pihlajamäki J, Graham TE, Kainulainen S, Kahn BB, Laakso M, Smith U. 2008. High circulating levels of RBP4 and mRNA levels of aP2, PGC-1alpha and UCP-2 predict improvement in insulin sensitivity following pioglitazone treatment of drug-naïve type 2 diabetic subjects. JOURNAL OF INTERNAL MEDICINE 263: 440-449. 2008

Ruotsalainen E, Vauhkonen I, Salmenniemi U, Pihlajamäki J, Punnonen K, Kainulainen S, Jalkanen S, Salmi M, Laakso M. 2008. Markes of endothelial dysfunction and low-grade inflammation are associated in the offspring of type 2 diabetic subjects. ATHEROSCLEROSIS 197: 271-277. 2008

Stancáková A, Pihlajamäki J, Kuusisto J, Stefan N, Fritsche A, Häring H, Andreozzi F, Succurro E, Sesti G, Boesgaard TW, Hansen T, Pedersen O, Jansson PA, Hammarstedt A, Smith U, Laakso M, for the EUGENE2 Consortium. 2008. Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 93 5: 1924-1930. 2008

Rutanen J, Pihlajamäki J, Vänttinen M, Salmenniemi U, Ruotsalainen E, Kuulasmaa T, Kainulainen S, Kuusisto J, Laakso M. 2007. Single nucleotide polymorphisms of the MCHR1 gene do not affect metabolism in humans. OBESITY (SILVER SPRING, MD.) 15: 2902-2907. 2007

Sittiwet C, Gylling H, Hallikainen M, Pihlajamäki J, Moilanen L, Laaksonen DE, Niskanen L, Ågren JJ, Laakso M, Miettinen TA. 2007. Cholesterol metabolism and non-cholesterol sterol distribution in lipoproreins of type 1 diabetes: The effect of improved glycemic control. ATHEROSCLEROSIS 194: 465-472. 2007

Hallikainen M, Kolehmainen M, Schwab U, Laaksonen DE, Niskanen L, Rauramaa R, Pihlajamäki J, Uusitupa M, Miettinen TA, Gylling H, Kolehmainen M. 2007. Serum adipokines are associated with cholesterol metabolism in the metabolic syndrome. CLINICA CHIMICA ACTA (AMSTERDAM) 383: 126-132. 2007

Gylling H, Hallikainen M, Kolehmainen M, Toppinen L, Pihlajamäki J, Mykkänen H, Ågren JJ, Rauramaa R, Laakso M, Miettinen TA. 2007. Cholesterol synthesis prevails over absorption in metabolic syndrome. TRANSLATIONAL RESEARCH 149: 310-316. 2007

Rutanen J, Pihlajamäki J, Vänttinen M, Salmenniemi U, Ruotsalainen E, Kuulasmaa T, Kainulainen S, Laakso M, Laakso M. 2007. Single nucleotide polymorphisms of the melanocortin-3 receptor gene are associated with substrate oxidation and first-phase insulin secretion in offspring of type 2 diabetic subjects. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 92: 1112-1117. 2007

Hallikainen M, Lyyra-Laitinen T, Laitinen T, Ågren JJ, Pihlajamäki J, Rauramaa R, Miettinen TA, Gylling H. 2006. Endothelial function in hypercholesterolemic subjects: Effects of plant stanol and sterol esters ATHEROSCLEROSIS 188: 425-432. 2006

Hammarstedt A, Pihlajamäki J, Sopasakis VR, Gogg S, Jansson P-A, Laakso M, Smith U. 2006. Visfatin is an adipokine, but it is not regulated by Thiazolidinediones. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 91: 1181-1184. 2006

Karinen H, Kärkkäinen P, Pihlajamäki J, Janatuinen E, Heikkinen M, Julkunen R, Kosma V-M, Naukkarinen A, Laakso M, Laakso M. 2006. HLA genotyping is useful in the evaluation of the risk for coelic disease in the 1st-degree relatives of patients with coeliac disease. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY 41: 1299-1304. 2006

Karinen H, Kärkkäinen P, Pihlajamäki J, Janatuinen E, Heikkinen M, Julkunen R, Kosma V-M, Naukkarinen A, Laakso M. 2006. Gene dose effect of the DQB1*0201 allele contributes to severity of coeliac disease. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY 41: 191-199. 2006

Koivisto AM, Helisalmi S, Pihlajamäki J, Hiltunen M, Koivisto K, Moilanen L, Kuusisto J, Helkala E-L, Hänninen T, Kervinen K, Kesäniemi YA, Laakso M, Soininen H, Koivisto AM, Helisalmi S, Hiltunen M, Soininen H, Laakso M. 2006. Association analysis of peroxisome proliferator-activated receptor gamma polymorphisms and late onset Alzhimer¿s disease in the Finnish population. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS 22: 449-453. 2006

Peltola P, Pihlajamäki J, Koutnikova H, Ruotsalainen E, Salmenniemi U, Vauhkonen I, Kainulainen S, Gylling H, Miettinen TA, Auwerx J, Laakso M, Laakso M. 2006. Visceral obesity is associated with high levels of serum squalene. OBESITY (SILVER SPRING, MD.) 14: 1155-1163. 2006

Pihlajamäki J, Salmenniemi U, Vänttinen M, Ruotsalainen E, Kuusisto J, Vauhkonen I, Kainulainen S, Ng MCY, Cox NJ, Bell CI, Laakso M, Laakso M. 2006. Common polymorphisms of calpain-10 are associated with abdominal obesity in subjects at high risk of type 2 diabetes. DIABETOLOGIA 49: 1560-1566. 2006

Ruotsalainen E, Salmenniemi U, Vauhkonen I, Pihlajamäki J, Punnonen K, Kainulainen S, Laakso M. 2006. Changes in inflammatory cytokines are related to impaired glucose tolerance in offspring of type 2 diabetic subjects. DIABETES CARE 29 12: 2714-2720. 2006

Vänttinen M, Nuutila P, Kuulasmaa T, Pihlajamäki J, Hällsten K, Virtanen KA, Lautamäki R, Peltoniemi P, Takala T, Viljanen APM, Knuuti J, Laakso M, Laakso M. 2005. Single nucleotide polymorphisms in the peroxisome proliferator-activated receptor delta gene are associated with skeletal muscle glucose uptake. DIABETES (NY) 54: 3587-3591. 2005

Vänttinen M, Nuutila P, Pihlajamäki J, Hällsten K, Virtanen KA, Lautamäki R, Peltoniemi P, Kemppainen J, Takala T, Viljanen APM, Knuuti J, Laakso M, Laakso M. 2005. The effect of the Ala12 allele of the peroxisome proliferator-activated receptor-gamma2 gene on skeletal muscle glucose uptake depends on obesity: a positron emission tomography study. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 90: 4249-4254. 2005

Pihlajamäki J, Kinnunen M, Ruotsalainen E, Salmenniemi U, Vauhkonen I, Kuulasmaa T, Kainulainen S, Laakso M, Laakso M. 2005. Haplotypes of PPARGC1A are associated with glucose tolerance, body mass index and insulin sensitivity in offpring of patients with type 2 diabetes. DIABETOLOGIA 48: 1331-1334. 2005

Salmenniemi U, Zacharova J, Ruotsalainen E, Vauhkonen I, Pihlajamäki J, Kainulainen S, Punnonen K, Laakso M, Laakso M. 2005. Association of adiponectin level and variants in the adiponectin gene with glucose metabolism, energy expenditure, and cytokines in offspring of type 2 diabetic patients. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 90: 4216-4223. 2005

Peltola P, Lumiaho A, Miettinen R, Pihlajamäki J, Sandford R, Laakso M, Laakso M. 2005. Genetics and phenotypic characteristics of autosomal dominant polycystic kidney disease in Finns. JOURNAL OF MOLECULAR MEDICINE 83: 638-646. 2005

Salmenniemi U, Ruotsalainen E, Vänttinen M, Vauhkonen I, Pihlajamäki J, Kainulainen S, Punnonen K, Laakso M. 2005. High amount of visceral fat mass is associated with multiple metabolic changes in offspring of type 2 diabetic patients. INTERNATIONAL JOURNAL OF OBESITY 29: 1464-1470. 2005

Rioux JD, Karinen H, Kocher K, McMahon SG, Kärkkäinen P, Janatuinen E, Heikkinen M, Julkunen R, Pihlajamäki J, Naukkarinen A, Kosma V-M, Daly MJ, Lander ES, Laakso M, Laakso M. 2004. Genomewide search and association studies in a Finnish celiac disease population: identification of a novel locus and replication of HLA and CTLA4 loci AMERICAN JOURNAL OF MEDICAL GENETICS. PART A 130: 345-350. 2004

Todorova B, Kubaszek A, Pihlajamäki J, Lindström J, Eriksson J, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Uusitupa M, Laakso M, Laakso M. 2004. The G-250A promoter polymorphism of the hepatic lipase gene predicts the conversion from impaired glucose tolerance to type 2 diabetes mellitus: the Finnish Diabetes Prevention Study. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 89 5: 2019-2023. 2004

Sivenius K, Pihlajamäki J, Partanen J, Niskanen L, Laakso M, Uusitupa M. 2004. Aldose reductase gene polymorphisms and peripheral nerve function in patients with type 2 diabetes. DIABETES CARE 27: 2021-2026. 2004

Rutanen J, Pihlajamäki J, Karhapää P, Vauhkonen I, Kuusisto J, Moilanen Mykkänen L, Laakso M, Laakso M. 2004. The Val103Ile polymorphism of melanocortin-4 receptor regulates energy expenditure and weight gain OBESITY (SILVER SPRING, MD.) 12: 1060-1066. 2004

Salmenniemi U, Ruotsalainen E, Pihlajamäki J, Vauhkonen I, Kainulainen S, Punnonen K, Vanninen E, Laakso M. 2004. Multiple abnormalities in glucose and energy metabolism and coordinated changes in levels of adiponectin, cytokines, and adhesion molecules in subjects with metabolic syndrome. CIRCULATION 110: 3842-3848. 2004

Pihlajamäki J, Vanhala M, Vanhala P, Laakso M, Laakso M. 2004. The Pro12Ala polymorphism of the PPARgamma2 gene regulates weight from birth to adulthood. OBESITY (SILVER SPRING, MD.) 12 2: 187-190. 2004

Pihlajamäki J, Gylling H, Miettinen TA, Laakso M. 2004. Insulin resistance is associated with increased cholesterol synthesis and decreased cholesterol absorption in normoglycemic men. JOURNAL OF LIPID RESEARCH 45: 507-512. 2004

Laukkanen O, Pihlajamäki J, Lindström J, Eriksson J, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Uusitupa M, Laakso M, for the Finnish diabetes prevention study group. 2004. Polymorphisms of the SUR1 (ABCC8) and Kir6.2 (KCNJ11) genes predict the conversion from impaired glucose tolerance to type 2 diabetes. The Finnish diabetes prevention study. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 89: 6286-6290. 2004

Laukkanen O, Pihlajamäki J, Lindström J, Eriksson J, Valle TT, Hämaläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Uusitupa M, Laakso M, for the Finnish Diabetes Prevention Study Group, Laakso M. 2004. Common polymorphisms in the genes regulating the early insulin signalling pathway: effects on weight change and the conversion from impaired glucose tolerance to Type 2 diabetes DIABETOLOGIA 47: 871-877. 2004

Gylling H, Hallikainen M, Pihlajamäki J, Ågren J, Laakso M, Rajaratnam RA, Rauramaa R, Miettinen TA, Laakso M. 2004. Polymorphisms in the ABCG5 and ABCG8 genes associate with cholesterol absorbtion and insulin sensitivity. JOURNAL OF LIPID RESEARCH 45: 1660-1665. 2004

Kossila M, Pihlajamäki J, Kärkkäinen P, Miettinen R, Kekäläinen P, Vauhkonen I, Ylä-Herttuala S, Laakso M, Laakso M. 2003. Promoter polymorphisms -359T/C and -303A/G of the catalytic subunit p110beta gene of human phosphatidylinositol 3-kinase are not associated with insulin secretion or insulin sensitivity in Finnish subjects. DIABETES CARE 26: 179-182. 2003

Kubaszek A, Pihlajamäki J, Karhapää P, Vauhkonen I, Laakso M, Laakso M. 2003. The K121Q polymorphism of the PC-1 gene is associated with insulin resistance but not with dyslipidemia DIABETES CARE 26: 464-467. 2003

Kubaszek A, Pihlajamäki J, Komarovski V, Lindi V, Lindström J, Eriksson J, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Uusitupa M, Laakso M, Laakso M. 2003. Promoter polymorphisms of the TNF-alfa (G-308A) and IL-6 (C-174G) genes predict the conversion from impaired glucose tolerance to type 2 diabetes. The Finnish Diabetes Prevention Study. DIABETES (NY) 52: 1872-1876. 2003

Kubaszek A, Pihlajamäki J, Punnonen K, Karhapää P, Vauhkonen I, Laakso M, Laakso M. 2003. The C-174G promoter polymorphism of the IL-6 gene affects energy expenditure and insulin sensitivity DIABETES (NY) 52: 558-561. 2003

Lumiaho A, Ikäheimo R, Pihlajamäki J, Miettinen R, Niemitukia L, Vanninen R, Lampainen E, Laakso M. 2003. Progression of kidney disease varies between families with defects in the polycystic kidney disease type 1 gene in eastern Finland. SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY 37: 352-358. 2003

Lumiaho A, Pihlajamäki J, Hartikainen J, Ikäheimo R, Miettinen R, Niemitukia L, Lampainen E, Laakso M. 2003. Insulin resistance is related to left ventricular hyperthrophy in patients with polycystic kidney disease type 1 AMERICAN JOURNAL OF KIDNEY DISEASES 41 6: 1219-1224. 2003

Pihlajamäki J, Karhapää P, Vauhkonen I, Kekäläinen P, Kareinen A, Viitanen L, Pesonen U, Kallio J, Uusitupa M, Laakso M. 2003. The Leu7Pro polymorphism of the neuropeptide Y gene regulates free fatty acid metabolism. METABOLISM: CLINICAL AND EXPERIMENTAL 52 5: 643-646. 2003

Pihlajamäki J, Ylinen M, Karhapää P, Vauhkonen I, Laakso M. 2003. The effect of the -308A allele of the TNF-alfa gene on insulin action is dependent on obesity. OBESITY (SILVER SPRING, MD.) 11 7: 912-917. 2003

Jääskeläinen P, Kuusisto J, Miettinen R, Kärkkäinen P, Kärkkäinen S, Heikkinen S, Peltola P, Pihlajamäki J, Vauhkonen I, Laakso M. 2002. Mutations in the cardiac myosin-binding protein C gene are the predominant cause of familial hypertrophic cardiomyopathy in eastern Finland JOURNAL OF MOLECULAR MEDICINE 80: 412-422. 2002

Vakkilainen J, Pajukanta P, Cantor RM, Nuotio IO, Lahdenperä S, Ylitalo K, Pihlajamäki J, Kovanen PT, Laakso M, Viikari JSA, Peltonen L, Taskinen M-R. 2002. Genetic influences contributing to LDL particle siz in familial combined hyperlipidaemia. EUROPEAN JOURNAL OF HUMAN GENETICS 10: 547-552. 2002

Pihlajamäki J, Austin M, Edwards K, Laakso M. 2001. A major gene effect on fasting insulin and insulin sensitivity in familial combined hyperlipidemia DIABETES (NY) 50: 2396-2401. 2001

Pihlajamäki J, Valve R, Karjalainen L, Karhapää P, Vauhkonen I, Laakso M. 2001. The hormone sensitive lipase gene in familial combined hyperlipidemia and insulin resistance EUROPEAN JOURNAL OF CLINICAL INVESTIGATION 31: 302-308. 2001

Viitanen L, Pihlajamäki J, Halonen P, Lehtonen M, Kareinen A, Lehto S, Laakso M. 2001. Association of angiotensin converting enzyme and plasminogen activator inhibitor-1 promoter gene polymorphisms with features of the insulin resistance syndrome in patients with premature coronary heart disease. ATHEROSCLEROSIS 157: 57-64. 2001

Viitanen L, Pihlajamäki J, Miettinen R, Kärkkäinen P, Vauhkonen I, Halonen P, Kareinen A, Lehto S, Laakso M. 2001. Apolipoprotein E gene promoter (-219G/T) polymorphism is associated with premature coronary heart disease. JOURNAL OF MOLECULAR MEDICINE 79: 732-737. 2001

Pihlajamäki J, Karjalainen L, Karhapää P, Vauhkonen I, Laakso M. 2000. Impaired free fatty acid suppression during hyperinsulinemia is a characteristic finding in familial combined hyperlipidemia, but insulin resistance is observed only in hypertriglyceridemic paitients ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 20: 164-170. 2000

Pihlajamäki J, Karjalainen L, Karhapää P, Vauhkonen I, Taskinen M-R, Deeb SS, Laakso M. 2000. G-250A substitution in promoter of hepatic lipase gene is associated with dyslipidemia and insulin resistance in healthy control subjects and in members of families with familial combined hyperlipidemia. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 20: 1789-95. 2000

Pihlajamäki J, Miettinen R, Valve R, Karjalainen L, Mykkänen L, Kuusisto J, Deeb S, Auwerx J, Laakso M. 2000. The Pro12Ala substitution in the peroxisome proliferator activated receptor gamma 2 is associated with an insulin-sensitive phenotype in families with familial combined hyperlipidemia and in nondiabetic elderly subjects with d. ATHEROSCLEROSIS 151: 567-574. 2000

Rissanen J, Markkanen A, Kärkkäinen P, Pihlajamäki J, Kekäläinen P, Mykkänen L, Kuusisto J, Karhapää P, Niskanen L, Laakso M. 2000. Sulfonylurea receptor 1 gene variants are associated with gestational diabetes and type 2 diabetes but not with altered secretion of insulin DIABETES CARE 23: 70-73. 2000

Valve R, Sivenius K, Miettinen R, Pihlajamäki J, Rissanen A, Deeb SS, Auwerx J, Uusitupa M, Laakso M. 1999. Two polymorphisms in the peroxisome proliferator-activated receptor-gamma gene are associated with severe overweight among obese women. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 84 10: 3708-3712. 1999

Pajukanta P, Terwilliger JD, Perola M, Hiekkalinna T, Nuotio I, Ellonen P, Parkkonen M, Hartiala J, Ylitalo K, Pihlajamäki J, Porkka K, Laakso M, Viikari J, Ehnholm C, Taskinen M-R, Peltonen L. 1999. Genomewide scan for familial combined hyperlipidemia genes in Finnish families, suggesting multiple susceptibility loci influencing triglyceride, cholesterol, and apolipoprotein B levels. AMERICAN JOURNAL OF HUMAN GENETICS 64: 1453-1463. 1999

Deeb SS, Fajas L, Nemoto M, Pihlajamäki J, Mykkänen L, Kuusisto J, Laakso M, Fujimoto W, Auwerx J. 1998. A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. NATURE GENETICS 20: 284-287. 1998

Jääskeläinen P, Soranta M, Miettinen R, Saarinen L, Pihlajamäki J, Silvennoinen K, Tikanoja T, Laakso M, Kuusisto J. 1998. The cardiac beta-myosin heavy chain gene is not the predominant gene for hypertrophic cardiomyopathy in the Finnish population. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 32 6: 1709-1716. 1998

Karjalainen L, Pihlajamäki J, Karhapää P, Laakso M. 1998. Impaired insulin-stimulated glucose oxidation and free fatty acid suppression in patients with familial combined hyperlipidemia: a precursor defect for dyslipidemia?. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 18: 1548-1553. 1998

Pajukanta P, Nuotio I, Terwilliger JD, Porkka KVK, Ylitalo K, Pihlajamäki J, Suomalainen AJ, Syvänen A-C, Lehtimäki T, Viikari JSA, Laakso M, Taskinen M-R, Ehnholm C, Peltonen L. 1998. Linkage of familial combined hyperlipidaemia to chromosome 1q21-q23. NATURE GENETICS 18: 369-373. 1998

Pihlajamäki J, Rissanen J, Valve R, Heikkinen S, Karjalainen L, Laakso M. 1998. Different regulation of free fatty acid levels and glucose oxidation by the Trp64Arg polymorphism of the beta3-adrenergic receptor gene and the promoter variant (A-3826G) of the uncoupling protein 1 gene in familial combined hyperlipidemia. METABOLISM: CLINICAL AND EXPERIMENTAL 47 11: 1397-1402. 1998

Pihlajamäki J, Rissanen J, Heikkinen S, Karjalainen L, Laakso M. 1997. Codon 54 polymorphism of the human intestinal fatty acid binding protein 2 gene is associated with dyslipidemias but not with insulin resistance in patients with familial combined hyperlipidemia. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 17: 1039-1044. 1997

Rissanen J, Kuopusjärvi M, Pihlajamäki J, Sipiläinen R, Heikkinen S, Vanhala M, Kekäläinen P, Kuusisto J, Laakso M. 1997. The trp64arg polymorphism of the beta3-adrenergic receptor gene DIABETES CARE 20 8: 1319-1323. 1997

Rissanen J, Pihlajamäki J, Heikkinen S, Kekäläinen P, Kuusisto J, Laakso M. 1997. The ala54thr polymorphism of the fatty acid binding protein 2 gene does not influence insulin sensitivity in Finnish nondiabetic and NIDDM subjects. DIABETES (NY) 46: 711-712. 1997

Rissanen J, Pihlajamäki J, Heikkinen S, Kekäläinen P, Mykkänen L, Kuusisto J, Kolle A, Laakso M. 1997. New variants in the glycogen synthase gene (GIn71His, Met416Val) in patients with NIDDM from eastern Finland. DIABETOLOGIA 40: 1313-1319. 1997

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