Jussi Pihlajamäki
Dekaani
Itä-Suomen yliopisto, Terveystieteiden tiedekunta
jussi.pihlajamaki@uef.fi | 050 344 0187
0503440187
050 3440187
050 344 0187
+358 50 344 0187
+35850 344 0187
050 3440 187
+358 50 3440 187
+35850 3440 187
+358 50 3440187
+35850 3440187
+358503440187
050 3440187
050 344 0187
+358 50 344 0187
+35850 344 0187
050 3440 187
+358 50 3440 187
+35850 3440 187
+358 50 3440187
+35850 3440187
+358503440187
Tutkimusryhmät
Julkaisut
222 kappaletta-
Associations between weight loss history and factors related to type 2 diabetes risk in the Stop Diabetes study
Halali, F.; Lapveteläinen, A.; Aittola, K.; Männikkö, R.; Tilles-Tirkkonen, T.; Järvelä-Reijonen, E.; Absetz, P.; Kolehmainen, M.; Schwab, U.; Lindström, J.; Lakka, T. A.; Pihlajamäki, J.; Karhunen, L.. International journal of obesity Published online: 12 January 2022: 1 - 8. 2022 -
Distinct contributions of metabolic dysfunction and genetic risk factors in the pathogenesis of non-alcoholic fatty liver disease
Luukkonen, Panu K; Qadri, Sami; Ahlholm, Noora; Porthan, Kimmo; Männistö, Ville; Sammalkorpi, Henna; Penttilä, Anne K; Hakkarainen, Antti; Lehtimäki, Tiina E; Gaggini, Melania; Gastaldelli, Amalia; Ala-Korpela, Mika; Orho-Melander, Marju; Arola, Johanna; Juuti, Anne; Pihlajamäki, Jussi; Hodson, Leanne; Yki-Järvinen, Hannele. Journal of hepatology 76 3: 526-535. 2022 -
Enhanced Eating Competence Is Associated with Improved Diet Quality and Cardiometabolic Profile in Finnish Adults with Increased Risk of Type 2 Diabetes
Aittola, Kirsikka; Karhunen, Leila; Männikkö, Reija; Järvelä-Reijonen, Elina; Mikkonen, Santtu; Absetz, Pilvikki; Kolehmainen, Marjukka; Schwab, Ursula; Harjumaa, Marja; Lindström, Jaana; Lakka, Timo; Tilles-Tirkkonen, Tanja; Pihlajamäki, Jussi. Nutrients 13 11: 4030. 2021 -
NR1H4 rs35724 G>C Variant Modulates Liver Damage in Nonalcoholic Fatty Liver Disease
Grimaudo, S; Dongiovanni, P; Pihlajamäki, J; Eslam, M; Yki-Järvinen, H; Pipitone, RM; Baselli, G; Cammà, C; Di Marco, V; Enea, M; Longo, M; Pennisi, G; Prati, D; Zito, R; Fracanzani, AL; Craxì, A; George, J; Romeo, S; Valenti, L; Petta, S. Liver international 41 11: 2712-2719. 2021 -
Comparison of Communication Channels for Large-Scale Type 2 Diabetes Risk Screening and Intervention Recruitment: Empirical Study
Jalkanen, Kari; Järvenpää, Riia; Tilles-Tirkkonen, Tanja; Martikainen, Janne; Aarnio, Emma; Männikkö, Reija; Rantala, Eeva; Karhunen, Leila; Kolehmainen, Marjukka; Harjumaa, Marja; Poutanen, Kaisa; Ermes, Miikka; Absetz, Pilvikki; Schwab, Ursula; Lakka, Timo; Pihlajamäki, Jussi; Lindström, Jaana; The StopDia Study Group. JMIR diabetes 6 3: e21356. 2021 -
Exome-wide Association Study on Alanine Aminotransferase Identifies Sequence Variants in the GPAM and APOE Associated with Fatty Liver Disease
Jamialahmadi, Oveis; Mancina, Rosellina Margherita; Ciociola, Ester; Tavaglione, Federica; Luukkonen, Panu K; Baselli, Guido; Malvestiti, Francesco; Thuillier, Dorothée; Raverdy, Violeta; Männistö, Ville; Pipitone, Rosaria Maria; Pennisi, Grazia; Prati, Daniele; Spagnuolo, Rocco; Petta, Salvatore; Pihlajamäki, Jussi; Pattou, François; Yki-Järvinen, Hannele; Valenti, Luca; Romeo, Stefano. Gastroenterology 160 5: 1634-1646. 2021 -
Sleep-time physiological recovery is associated with eating habits in distressed working-age Finns with overweight: secondary analysis of a randomised controlled trial
Järvelä-Reijonen, Elina; Järvinen, Suvi; Karhunen, Leila; Föhr, Tiina; Myllymäki, Tero; Sairanen, Essi; Lindroos, Sanni; Peuhkuri, Katri; Hallikainen, Maarit; Pihlajamäki, Jussi; Puttonen, Sampsa; Korpela, Riitta; Ermes, Miikka; Lappalainen, Raimo; Kujala, Urho M; Kolehmainen, Marjukka; Laitinen, Jaana. Journal of occupational medicine and toxicology 16 1: 23. 2021 -
Oxygen-18 and Carbon-13 isotopes in eCO 2 and erythrocytes carbonic anhydrase activity of Finnish prediabetic population
Kårlund, Anna; Kääriäinen, Teemu; Kostamo, Vili M; Kokkola, Tarja; Kolehmainen, Marjukka; Lakka, Timo A; Pihlajamäki, Jussi; Manninen, Albert. Journal of breath research 15 2: 021001. 2021 -
The FADS1 Genotype Modifes Metabolic Responses to the Linoleic Acid and Alpha-linolenic Acid Containing Plant Oils-Genotype Based Randomized Trial FADSDIET2
Lankinen, MA; de Mello, VD; Meuronen, T; Sallinen, T; Ågren, J; Virtanen, KA; Laakso, M; Pihlajamäki, J; Schwab, U. Molecular nutrition and food research 65 7: 2001004. 2021 -
Endothelial function and concentrations of high-sensitivity C-reactive protein, interleukin-6, and tumor necrosis factor-alpha during a long agonist IVF protocol
Leppänen, Jonna; Randell, Kaisa; Schwab, Ursula; Pihlajamäki, Jussi; Romppanen, Jarkko; Keski-Nisula, Leea; Heinonen, Seppo; Laitinen, Tomi. Journal of reproductive immunology 148: 103434. 2021 -
Digitalization as an Engine for Change? Building a Vision Pathway towards a Sustainable Health Care System by Using the MLP and Health Economic Decision Modelling
Leväsluoto, Johanna; Kohl, Johanna; Sigfrids, Anton; Pihlajamäki, Jussi; Martikainen, Janne. Sustainability 13 23: 13007. 2021 -
Formation and Validation of the Healthy Diet Index (HDI) for Evaluation of Diet Quality in Healthcare
Lindström, Jaana; Aittola, Kirsikka; Pölönen, Auli; Hemiö, Katri; Ahonen, Kirsti; Karhunen, Leila; Männikkö, Reija; Siljamäki-Ojansuu, Ulla; Tilles-Tirkkonen, Tanja; Virtanen, Eeva; Pihlajamäki, Jussi; Schwab, Ursula. International journal of environmental research and public health 18 5: 2362. 2021 -
FADS1 rs174550 genotype and high linoleic acid diet modify plasma PUFA phospholipids in a dietary intervention study
Meuronen, Topi; Lankinen, Maria A.; Kärkkäinen, Olli; Laakso, Markku; Pihlajamäki, Jussi; Hanhineva, Kati; Schwab, Ursula. European journal of nutrition 2022; 61 2: 1109-1120. 2021 -
Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes
Pan, David Z; Miao, Zong; Comenho, Caroline; Rajkumar, Sandhya; Koka, Amogha; Lee, Seung Hyuk T; Alvarez, Marcus; Kaminska, Dorota; Ko, Arthur; Sinsheimer, Janet S; Mohlke, Karen L; Mancuso, Nicholas; Muñoz-Hernandez, Linda Liliana; Herrera-Hernandez, Miguel; Tusié-Luna, Maria Teresa; Aguilar-Salinas, Carlos; Pietiläinen, Kirsi H; Pihlajamäki, Jussi; Laakso, Markku; Garske, Kristina M; et al.. Genome medicine 13: 123. 2021 -
Choice Architecture Cueing to Healthier Dietary Choices and Physical Activity at the Workplace: Implementation and Feasibility Evaluation
Rantala, Eeva; Vanhatalo, Saara; Tilles-Tirkkonen, Tanja; Kanerva, Markus; Hansen, Pelle Guldborg; Kolehmainen, Marjukka; Männikkö, Reija; Lindström, Jaana; Pihlajamäki, Jussi; Poutanen, Kaisa; Karhunen, Leila; Absetz, Pilvikki. Nutrients 13 10: 3592. 2021 -
Indole-3-Propionic Acid, a Gut-Derived Tryptophan Metabolite, Associates with Hepatic Fibrosis
Sehgal, Ratika Ilha, Mariana Vaittinen, Maija Kaminska, Dorota Männistö, Ville Kärjä, Vesa Tuomainen, Marjo Hanhineva, Kati Romeo, Stefano Pajukanta, Päivi Pihlajamäki, Jussi de Mello, Vanessa D.. Nutrients 13 10: 3509. 2021 -
Integrative analysis of liver-specific non-coding regulatory SNPs associated with the risk of coronary artery disease
Selvarajan, Ilakya; Toropainen, Anu; Garske, Kristina M.; López Rodríguez, Maykel; Ko, Arthur; Miao, Zong; Kaminska, Dorota; Õunap, Kadri; Örd, Tiit; Ravindran, Aarthi; Liu, Oscar H.; Moreau, Pierre R.; Jawahar Deen, Ashik; Männistö, Ville; Pan, Calvin; Levonen, Anna-Liisa; Lusis, Aldons J.; Heikkinen, Sami; Romanoski, Casey E.; Pihlajamäki, Jussi; Pajukanta, Päivi; Kaikkonen, Minna U.. American journal of human genetics 108 3: 411-430. 2021 -
Differential Mitochondrial Gene Expression in Adipose Tissue Following Weight Loss Induced by Diet or Bariatric Surgery
van der Kolk, Birgitta; Muniandy, Maheswary; Kaminska, Dorota; Alvarez, Marcus; Ko, Arthur; Miao, Zong; Valsesia, Armand; Langin, Dominique; Vaittinen, Maija; Pääkkönen, Mirva; Jokinen, Riikka; Kaye, Sanna; Heinonen, Sini; Virtanen, Kirsi A; Andersson, Daniel; Männistö, Ville; Saris, Wim; Astrup, Arne; Rydén, Mikael; Blaak, Ellen; Pajukanta, Päivi; Pihlajamäki, Jussi; Pietiläinen, Kirsi H. Journal of clinical endocrinology and metabolism 106 5: 1312-1324. 2021 -
Change in abdominal, but not femoral subcutaneous fat CT-radiodensity is associated with improved metabolic profile after bariatric surgery
Dadson, Prince; Rebelos, Eleni; Honka, Henri; Juárez-Orozco, Luis E; Kalliokoski, Kari K; Iozzo, Patricia; Teuho, Jarmo; Salminen, Paulina; Pihlajamäki, Jussi; Hannukainen, Jarna C; Nuutila, Pirjo. Nutrition metabolism and cardiovascular diseases 30 12: P2363-2371. 2020 -
Parental metabolic syndrome epigenetically reprograms offspring hepatic lipid metabolism in mice
De Jesus, Dario; Orime, Kazuki; Kaminska, Dorota; Kimura, Tomohiko; Basile, Giorgio; Wang, Chih-Hao; Haertle, Larissa; Riemens, Renzo; Brown, Natalie; Hu, Jiang; Männistö, Ville; Silva, Amélia; Dirice, Ercument; Tseng, Yu-Hua; Haaf, Thomas; Pihlajamäki, Jussi; Kulkarni, Rohit. Journal of clinical investigation 130 5: 2391-2407. 2020 -
Serum aromatic and branched-chain amino acids associated with NASH demonstrate divergent associations with serum lipids
de Mello, Vanessa D; Sehgal, Ratika; Männistö, Ville; Klåvus, Anton; Nilsson, Emma; Perfilyev, Alexander; Kaminska, Dorota; Miao, Zong; Pajukanta, Päivi; Ling, Charlotte; Hanhineva, Kati; Pihlajamäki, Jussi. Liver international 2021; 41 4: 754-763. 2020 -
Genetic variants in the MTHFR are not associated with fatty liver disease.
De Vincentis, Antonio; Mancina, Rosellina Margherita; Pihlamajäki, Jussi; Männistö, Ville; Petta, Salvatore; Dongiovanni, Paola; Fracanzani, Anna; Valenti, Luca; Tavaglione, Federica; Romeo, Stefano; Vespasiani-Gentilucci, Umberto. Liver international 40 8: 1934-1940. 2020 -
Epigenetic markers associated with metformin response and intolerance in drug-naïve patients with type 2 diabetes
García-Calzón, Sonia; Perfilyev, Alexander; Martinell, Mats; Ustinova, Monta; Kalamajski, Sebastian; Franks, Paul W; Bacos, Karl; Elbere, Ilze; Pihlajamäki, Jussi; Volkov, Petr; Vaag, Allan; Groop, Leif; Maziarz, Marlena; Klovins, Janis; Ahlqvist, Emma; Ling, Charlotte. Science translational medicine 12 561: eaaz1803. 2020 -
Mucosal-associated invariant T cell alterations during the development of human type 1 diabetes
Gazali, Ahmad M; Schroderus, Anna-Mari; Näntö-Salonen, Kirsti; Rintamäki, Reeta; Pihlajamäki, Jussi; Knip, Mikael; Veijola, Riitta; Toppari, Jorma; Ilonen, Jorma; Kinnunen, Tuure. Diabetologia 63: 2396-2409. 2020 -
PCSK9 rs11591147 R46L loss-of-function variant protects against liver damage in individuals with NAFLD
Grimaudo, Stefania; Bartesaghi, Stefano; Rametta, Raffaela; Marra, Fabio; Margherita Mancina, Rosellina; Pihlajamäki, Jussi; Kakol-Palm, Dorota; Andreasson, Anne-Christine; Dongiovanni, Paola; Ludovica Fracanzani, Anna; Lori, Giulia; Männistö, Ville; Pellegrini, Giovanni; Bohlooly-Y, Mohammad; Pennisi, Grazia; Maria Pipitone, Rosaria; Spagnuolo, Rocco; Craxi, Antonio; Linden, Daniel; Valenti, Luca. Liver international 2021; 41 2: 321-332. 2020 -
Internet-Based Lifestyle Intervention to Prevent Type 2 Diabetes Through Healthy Habits: Design and 6-Month Usage Results of Randomized Controlled Trial
Harjumaa, Marja; Absetz, Pilvikki; Ermes, Miikka; Mattila, Elina; Männikkö, Reija; Tilles-Tirkkonen, Tanja; Lintu, Niina; Schwab, Ursula; Umer, Adil; Leppänen, Juha; Pihlajamäki, Jussi. JMIR Diabetes 5 3: e15219. 2020 -
Effect of metabolic state on implicit and explicit responses to food in young healthy females
Juvonen, K; Lapveteläinen, A; Närväinen, J; Absetz, P; Kantanen, T; Kolehmainen, M; Sinikallio, S; Pihlajamäki, J; Karhunen, L. Appetite 148: 104593. 2020 -
The Effects of Acceptance and Commitment Therapy (ACT) Intervention on Inflammation and Stress Biomarkers: a Randomized Controlled Trial
Järvelä-Reijonen, Elina; Puttonen, Sampsa; Karhunen, Leila; Sairanen, Essi; Laitinen, Jaana; Kolehmainen, Mikko; Pihlajamäki, Jussi; Kujala, Urho M; Korpela, Riitta; Ermes, Miikka; Lappalainen, Raimo; Kolehmainen, Marjukka. International journal of behavioral medicine 27 5: 539-555. 2020 -
Dietary fiber from oat and rye brans ameliorate Western diet-induced body weight gain and hepatic inflammation by the modulation of short chain fatty acids, bile acids, and tryptophan metabolism
Kundi, Zuzanna Maria; Lee, Jetty Chung-Yung; Pihlajamäki, Jussi; Chan, Chi Bun; Leung, Kin Sum; So, Stephanie Sik Yu; Nordlund, Emilia; Kolehmainen, Marjukka; El-Nezami, Hani. Molecular nutrition and food research 2021; 65 1: 1900580. 2020 -
The effect of different estradiol levels on carotid artery distensibility during a long agonist IVF protocol
Leppänen, Jonna; Randell, Kaisa; Schwab, Ursula; Pihlajamäki, Jussi; Keski-Nisula, Leea; Laitinen, Tomi; Heinonen, Seppo. Reproductive biology and endocrinology 18 1: 44. 2020 -
StopDian opetukset: viesti vahvasti ja tee osallistuminen helpoksi
Lindström, Jaana; Harjumaa, Marja; Pihlajamäki, Jussi. DIABETES JA LÄÄKÄRI 49 1: 9-14. 2020 -
Protein Phosphatase 1 Regulatory Subunit 3B Genotype at rs4240624 Has a Major Effect on Gallbladder Bile Composition
Männistö, Ville; Kaminska, Dorota; Käkelä, Pirjo; Neuvonen, Mikko; Niemi, Mikko; Alvarez, Marcus; Pajukanta, Päivi; Romeo, Stefano; Nieuwdorp, Max; Groen, Albert K; Pihlajamäki, Jussi. Hepatology communications 2021; 5 2: 244-257. 2020 -
Diabetic phenotype in mouse and humans reduces the number of microglia around ß-amyloid plaques
Natunen, Teemu; Martiskainen, Henna; Marttinen, Mikael; Gabbouj, Sami; Koivisto, Hennariikka; Kemppainen, Susanna; Kaipainen, Satu; Takalo, Mari; Svobodová, Helena; Leppänen, Luukas; Kemiläinen, Benjam; Ryhänen, Simo; Kuulasmaa, Teemu: Rahunen, Eija: Juutinen, Sisko; Mäkinen, Petra; Miettinen, Pasi; Rauramaa, Tuomas; Pihlajamäki, Jussi; Haapasalo, Annakaisa; et al [incl. Leinonen, Ville; Tanila, H. Molecular neurodegeneration 15: 66. 2020 -
Miten tyypin 2 diabeteksen ehkäisy pitäisi järjestää?
Pihlajamäki, Jussi; Lindström, Jaana. Duodecim 136 5: 477-478. 2020 -
LPIAT1/MBOAT7 depletion increases triglyceride synthesis fueled by high phosphatidylinositol turnover
Tanaka, Yuki; Shimanaka, Yuta; Caddeo, Andrea; Kubo, Takuya; Mao, Yanli; Kubota, Tetsuya; Kubota, Naoto; Yamauchi, Toshimasa; Mancina, Rosellina Margherita; Baselli, Guido; Luukkonen, Panu; Pihlajamäki, Jussi; Yki-Järvinen, Hannele; Valenti, Luca; Arai, Hiroyuki; Romeo, Stefano; Kono, Nozomu. Gut 2021; 70 1: 180-193. 2020 -
StopDia-hankkeesta vinkkejä terveyden edistämiseen ja hyte-johtamiseen
Tilles-Tirkkonen, Tanja; Männikkö, Reija; Lindström, Jaana; Harjumaa, Marja; Aittola, Kirsikka; Järvelä-Reijonen, Elina; Rantala, Eeva; Martikainen, Janne; Lakka, Timo; Pihlajamäki, Jussi. Ravitsemusasiantuntija 6 1: 4-7. 2020 -
Novel Lipid Long Intervening Noncoding RNA, Oligodendrocyte Maturation-Associated Long Intergenic Noncoding RNA, Regulates the Liver Steatosis Gene Stearoyl-Coenzyme A Desaturase As an Enhancer RNA
Benhammou, Jihane N; Ko, Arthur; Alvarez, Marcus; Kaikkonen, Minna U; Rankin, Carl; Garske, Kristina M; Padua, David; Bhagat, Yash; Kaminska, Dorota; Karja, Vesa; Pihlajamäki, Jussi; Pisegna, Joseph R; Pajukanta, Päivi. Hepatology communications 3 10: 1356-1372. 2019 -
Epigenome-Wide Association Study of Incident Type 2 Diabetes in a British Population: EPIC-Norfolk Study
Cardona, A; Day, FR; Perry, JRB; Loh, M; Chu, AY; Lehne, B; Paul, DS; Lotta, LA; Stewart, ID; Kerrison, ND; Scott, RA; Khaw, KT; Forouhi, NG; Langenberg, C; Liu, C; Mendelson, MM; Levy, D; Beck, S; Leslie, RD; Dupuis, J; et al. [incl. Pihlajamäki, J]. Diabetes 68 12: 2315-2326. 2019 -
PCSK7 gene variation bridges atherogenic dyslipidemia with hepatic inflammation in NAFLD patients
Dongiovanni, P; Meroni, M; Baselli, GA; Mancina, RM; Ruscica, M; Longo, M; Rametta, R; Cespiati, A; Pelusi, S; Ferri, N; Ranzani, V; Nobili, V; Pihlajamaki, J; Fracanzani, AL; Badiali, S; Petta, S; Fargion, S; Romeo, S; Kozlitina, J; Valenti, L. Journal of lipid research 60 6: 1144-1153. 2019 -
Decreased plasma serotonin and other metabolite changes in healthy adults after consumption of wholegrain rye: an untargeted metabolomics study
Keski-Rahkonen, Pekka; Kolehmainen, Marjukka; Lappi, Jenni; Micard, Valerie; Jokkala, Jenna; Rosa-Sibakov, Natalia; Pihlajamäki, Jussi; Kirjavainen, Pirkka V; Mykkänen, Hannu; Poutanen, Kaisa; Gunter, Marc J; Scalbert, Augustin; Hanhineva, Kati. American journal of clinical nutrition 109 6: 1630-1639. 2019 -
Inflammatory response to dietary linoleic acid depends on FADS1 genotype
Lankinen, MA; Fauland, A; Shimizu, BI; Ågren, J; Wheelock, CE; Laakso, M; Schwab, U; Pihlajamäki, J. American journal of clinical nutrition 109 1: 165-175. 2019 -
Healthy Nordic Diet Modulates the Expression of Genes Related to Mitochondrial Function and Immune Response in Peripheral Blood Mononuclear Cells from Subjects with the Metabolic Syndrome - A SYSDIET Sub-Study
Myhrstad, MC; de Mello, VD; Dahlman, I; Kolehmainen, M; Paananen, J; Rundblad, A; Carlberg, C; Olstad, OK; Pihlajamäki, J; Holven, KB; Hermansen, K; Dragsted, LO; Gunnarsdottir, I; Cloetens, L; Storm, MU; Åkesson, B; Rosqvist, F; Hukkanen, J; et al. (incl. Schwab, U; Uusitupa, M). Molecular nutrition and food research 63 13: 1801405. 2019 -
Hyvinvoinnin ja osallisuuden edistäminen vaatii uusia vaikuttavia keinoja
Mäki-Opas, Tomi; Tilles-Tirkkonen, Tanja; Saari, Eveliina; Järvenpää, Riia; Lindström, Jaan; Karhunen, Leila; Kurki, Marjo; Pihlajamäki, Jussi; Niemi, Anna-Maija; Laaksonen, Linda Maria; Korkiakangas, Eveliina; Lakka, Timo; Vaarama, Marja; Laitinen, Jaana. Policy Brief / SA 13.3.2019: 1-12. 2019 -
Total liver phosphatidylcholine content associates with non-alcoholic steatohepatitis and glycine N-methyltransferase expression
Männistö, V; Kaminska, D; Kärjä, V; Tiainen, M; de Mello, VD; Hanhineva, K; Soininen, P; Ala-Korpela, M; Pihlajamäki, J. Liver international 39 10: 1895-1905. 2019 -
Fatty liver index as a predictor of increased risk of cardiometabolic disease: finding from the Kuopio Ischaemic Heart Disease Risk Factor Study Cohort
Olubamwo OO, Virtanen JK, Pihlajamaki J, Mantyselka P, Tuomainen TP. BMJ open 9 9: e031420. 2019 -
Association of fatty liver disease with mortality outcomes in an Eastern Finland male cohort
Olubamwo, Olubunmi O; Virtanen, Jyrki K; Pihlajamäki, Jussi; Tuomainen, Tomi-Pekka. BMJ open gastroenterology 6 1: e000219. 2019 -
Association of fatty liver index with risk of incident type 2 diabetes by metabolic syndrome status in an Eastern Finland male cohort: a prospective study
Olubamwo, OO; Virtanen, JK; Pihlajamaki, J; Tuomainen, TP. BMJ open 9 7: e026949. 2019 -
Prevalence and Risk Factors if Significant Fibrosis in Patients With Nonalcoholic Fatty Liver Without Steatohepatitis
Pelusi, S; Cespiati, A; Rametta, R; Pennisi, G; Mannisto, V; Rosso, C; Baselli, G; Dongiovanni, P; Fracanzani, AL; Badiali, S; Maggioni, M; Craxi, A; Fargion, S; Prati, D; Nobili, V; Bugianesi, E; Romeo, S; Pihlajamaki, J; Petta, S; Valenti, L. Clinical gastroenterology and hepatology 17 11: 2310-2319.e6. 2019 -
Digitally supported program for type 2 diabetes risk identification and risk reduction in real-world setting: protocol for the StopDia model and randomized controlled trial
Pihlajamäki, J; Männikkö, R; Tilles-Tirkkonen, T; Karhunen, L; Kolehmainen, M; Schwab, U; Lintu, N; Paananen, J; Järvenpää, R; Harjumaa, M; Martikainen, J; Kohl, J; Poutanen, K; Ermes, M; Absetz, P; Lindström, J; Lakka, TA. Bmc public health 19: 255. 2019 -
Laparoscopic Roux-en-Y gastric bypass surgery influenced pharmacokinetics of several drugs given as a cocktail with the highest impact observed for CYP1A2, CYP2C8 and CYP2E1 substrates
Puris, E; Pasanen, M; Ranta, VP; Gynther, M; Petsalo, A; Käkelä, P; Männistö, V; Pihlajamäki, J. Basic and clinical pharmacology and toxicology 125 2: 123-132. 2019 -
Eating Competence Is Associated with Lower Prevalence of Obesity and Better Insulin Sensitivity in Finnish Adults with Increased Risk for Type 2 Diabetes: The StopDia Study
Tilles-Tirkkonen, Tanja; Aittola, Kirsikka; Männikkö, Reija; Absetz, Pilvikki; Kolehmainen, Marjukka; Schwab, Ursula; Lindström, Jaana; Lakka, Timo; Pihlajamäki, Jussi; Karhunen, Leila. Nutrients 2020; 12 1: 104. 2019 -
An Isocaloric Nordic Diet Modulates RELA and TNFRSF1A Gene Expression in Peripheral Blood Mononuclear Cells in Individuals with Metabolic Syndrome-A SYSDIET Sub-Study
Ulven, SM; Holven, KB; Rundblad, A; Myhrstad, MCW; Leder, L; Dahlman, I; Mello, VD; Schwab, U; Carlberg, C; Pihlajamäki, J; Hermansen, K; Dragsted, LO; Gunnarsdottir, I; Cloetens, L; Åkesson, B; Rosqvist, F; Hukkanen, J; Herzig, KH; Savolainen, MJ; Risérus, U; et al. [incl. Uusitupa, M]. Nutrients 11 12: 2932. 2019 -
Liver DNA methylation of FADS2 associates with FADS2 genotypex
Walle, P; Männistö, V; de Mello, VD; Vaittinen, M; Perfilyev, A; Hanhineva, K; Ling, C; Pihlajamäki, J. Clinical epigenetics 11 1: 10. 2019 -
Brown adipose tissue lipid metabolism in morbid obesity : effect of bariatric surgery-induced weight loss
Dadson, Prince; Hannukainen, Jarna C; Din, Mueez U; Lahesmaa, Minna; Kalliokoski, Kari K; Iozzo, Patricia; Pihlajamäki, Jussi; Karlsson, Henry K; Parkkola, Riitta; Salminen, Paulina; Virtanen, Kirsi A; Nuutila, Pirjo. DIABETES, OBESITY AND METABOLISM 20 5: 1280-1288. 2018 -
Protein Phosphatase 1 Regulatory Subunit 3B Gene Variation Protects Against Hepatic Fat Accumulation and Fibrosis in Individuals at High Risk of Nonalcoholic Fatty Liver Disease
Dongiovanni, Paola; Meroni, Marica; Mancina, Rosellina M; Baselli, Guido; Rametta, Raffaela; Pelusi, Serena; Männisto, Ville; Fracanzani, Anna L; Badiali, Sara; Miele, Luca; Grimaudo, Stefania; Petta, Salvatore; Bugianesi, Elisabetta; Soardo, Giorgio; Fargion, Silvia; Pihlajamäki, Jussi; Romeo, Stefano; Valenti, Luca. Hepatology communications 2 6: 666-675. 2018 -
Sex Differences in the Methylome and Transcriptome of the Human Liver and Circulating HDL-Cholesterol Levels
García-Calzón, Sonia; Perfilyev, Alexander; de Mello, Vanessa D; Pihlajamäki, Jussi; Ling, Charlotte. Journal of clinical endocrinology and metabolism 103 12: 4395-4408. 2018 -
Effector T Cell Resistance to Suppression and STAT3 Signaling during the Development of Human Type 1 Diabetes
Ihantola, EL; Viisanen, T; Gazali, AM; Näntö-Salonen, K; Juutilainen, A; Moilanen, L; Rintamäki, R; Pihlajamäki, J; Veijola, R; Toppari, J; Knip, M; Ilonen, J; Kinnunen, T. JOURNAL OF IMMUNOLOGY (BALTIMORE) 201 4: 1144-1153. 2018 -
The effects of acceptance and commitment therapy on eating behavior and diet delivered through face-to-face contact and a mobile app: a randomized controlled trial
Järvelä-Reijonen, Elina; Karhunen, Leila; Sairanen, Essi; Muotka, Joona; Lindroos, Sanni; Laitinen, Jaana; Puttonen, Sampsa; Peuhkuri, Katri; Hallikainen, Maarit; Pihlajamäki, Jussi; Korpela, Riitta; Ermes, Miikka; Lappalainen, Raimo; Kolehmainen, Marjukka. INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY 15: 22. 2018 -
Small Intestinal Length Associates with Serum Triglycerides Before and After LRYGB
Käkelä, Pirjo; Männistö, Ville; Vaittinen, Maija; Venesmaa, Sari; Kärjä, Vesa; Virtanen, Kirsi; Paajanen, Hannu; Pihlajamäki, Jussi. Obesity surgery 28 12: 3969-3975. 2018 -
Evaluation of the effect of bariatric surgery-induced weight loss on knee gait and cartilage degeneration
Liukkonen, MK; Mononen, ME; Vartiainen, P; Kaukinen, P; Bragge, T; Suomalainen, JS; Malo, MKH; Venesmaa, S; Käkelä, P; Pihlajamäki, J; Karjalainen, PA; Arokoski, JP; Korhonen, R. JOURNAL OF BIOMECHANICAL ENGINEERING 14 4: 041008. 2018 -
Association of fatty liver index with the risk of incident cardiovascular disease and acute myocardial infarction.
Olubamwo, Olubamwo O; Virtanen, Jyrki K; Voutilainen, Ari; Kauhanen, Jussi; Pihlajamäki, Jussi; Tuomainen, Tomi-Pekka. EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 30 9: 1047-1054. 2018 -
Incidence, comorbidities, and mortality in idiopathic normal pressure hydrocephalus
Pyykkö, OT; Nerg, O; Niskasaari, HM; Niskasaari, T; Koivisto, AM; Hiltunen, M; Pihlajamäki, J; Rauramaa, T; Kojoukhova, M; Alafuzoff, I; Soininen, H; Jääskeläinen, JE; Leinonen, V. WORLD NEUROSURGERY 112: e624-e631. 2018 -
Measured energy content of frequently purchased restaurant meals: multi-country cross sectional study
Roberts, SB; Das, SK; Suen, VMM; Pihlajamäki, J; Kuriyan, R; Steiner-Asiedu, M; Taetzsch, A; Anderson, AK; Silver, RE; Barger, K; Krauss, A; Karhunen, L; Zhang, X; Hambly, C; Schwab, U; Triffoni-Melo, AT; Taylor, SF; Economos, C; Kurpad, AV; Speakman, JR. BMJ 363: k4864. 2018 -
Kirjasto- ja tietopalvelut on turvattava
Saarti, Jarmo; Pihlajamäki, Jussi; Vanninen, Esko. SUOMEN LÄÄKÄRILEHTI 73 3: 117. 2018 -
Serum, liver and bile sitosterol and sitostanol in obese patients with and without NAFLD
Tauriainen, Milla-Maria; Männistö, Ville; Kaminska, Dorota; Vaittinen, Maija; Kärjä, Vesa; Käkelä, Pirjo; Venesmaa, Sari; Gylling, Helena; Pihlajamäki, Jussi. Bioscience reports 38 2: 1-9. 2018 -
Sosioekonomisesti heikommassa asemassa olevien kiinnostus ja mahdollisuudet digitaalisten terveyspalveluiden käyttöön
Tilles-Tirkkonen, Tanja; Lappi, Jenni; Karhunen, Leila; Harjumaa, Marja; Absetz, Pilvikki; Pihlajamäki, Jussi. Yhteiskuntapolitiikka 83 3: 317-323. 2018 -
Uudet toimintamallit hyvinvoinnin ja terveyden edistämisessä
Tilles-Tirkkonen, Tanja; Mäki-Opas, Tomi; Vaarama, Marja; Logren, Aija; Pentikäinen, Saara; Tiitinen, Sanni; Ilomäki, Sakari; Pihlajamäki, Jussi; Laitinen, Jaana. Sosiaalilääketieteellinen aikakauslehti 55 4: 364-369. 2018 -
Associations of serum indolepropionic acid, a gut microbiota metabolite, with type 2 diabetes and low-grade inflammation in high-risk individuals
Tuomainen, Marjo; Lindström, Jaana; Lehtonen, Marko; Auriola, Seppo; Pihlajamäki, Jussi; Peltonen, Markku; Tuomilehto, Jaakko; Uusitupa, Matti; de Mello, Vanessa D; Hanhineva, Kati. Nutrition and diabetes 8: 35. 2018 -
Hepatic DPP4 DNA Methylation Associates With Fatty Liver
Baumeier Christian, Saussenthaler Sophie, Kammel Anne, Jähnert Markus, Schlüter Luisa, Hesse Deike, Canouil Mickaël, Lobbens Stephane, Caiazzo Robert, Raverdy Violeta, Pattou François, Nilsson Emma, Pihlajamäki Jussi, Ling Charlotte, Froguel Philippe, Schürmann Annette, Schwenk Robert W. DIABETES (NY) 66 1: 25 - 35. 2017 -
Fatty acid uptake and blood flow in adipose tissue compartments of morbidly obese subjects with or without type 2 diabetes: Effects of bariatric surgery
Dadson P, Ferrannini E, Landini L, Hannukainen JC, Kalliokoski KK, Vaittinen M, Honka H, Karlsson HK, Tuulari JJ, Soinio M, Salminen P, Parkkola R, Pihlajamäki J, Iozzo P, Nuutila P. AMERICAN JOURNAL OF PHYSIOLOGY. ENDOCRINOLOGY AND METABOLISM 313 2: E175-E182. 2017 -
Fasting serum hippuric acid is elevated after bilberry (Vaccinium myrtillus) consumption and associates with improvement of fasting glucose levels and insulin secretion in persons at high risk of developing type 2 diabetes
de Mello VD, Lankinen MA, Lindström J, Puupponen-Pimiä R, Laaksonen DE, Pihlajamäki J, Lehtonen M, Uusitupa M, Tuomilehto J, Kolehmainen M, Törrönen R, Hanhineva K. Molecular Nutrition & Food Research 61 9: 1700019. 2017 -
Human liver epigenetic alterations in non-alcoholic steatohepatitis are related to insulin action
de Mello VD, Matte A, Perfilyev A, Männistö V, Rönn T, Nilsson E, Käkelä P, Ling C, Pihlajamäki J. Epigenetics [Epub 2017 Feb 23]: 287-295. 2017 -
Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study
de Mello VD, Paananen J, Lindstrom J, Lankinen MA, Shi L, Kuusisto J, Pihlajamaki J, Auriola S, Lehtonen M, Rolandsson O, Bergdahl IA, Nordin E, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Landberg R, Eriksson JG, Tuomilehto J, Hanhineva K, Uusitupa M. Scientific Reports 7: 46337. 2017 -
Causal relationship of hepatic fat with liver damage and insulin resistance in nonalcoholic fatty liver
Dongiovanni P, Stender S, Pietrelli A, Mancina RM, Cespiati A, Petta S, Pelusi S, Pingitore P, Badiali S, Maggioni M, Mannisto V, Grimaudo S, Pipitone RM, Pihlajamaki J, Craxi A, Taube M, Carlsson LMS, Fargion S, Romeo S, Kozlitina J et al.. Journal of internal medicine 2018; 283 4: 356-370. 2017 -
Diabetes medication associates with DNA methylation of metformin transporter genes in the human liver
García-Calzón Sonia, Perfilyev Alexander, Männistö Ville, de Mello Vanessa D, Nilsson Emma, Pihlajamäki Jussi, Ling Charlotte. Clinical Epigenetics 9: 102. 2017 -
Comprehensive pharmacogenomic study reveals an important role of UGT1A3 in montelukast pharmacokinetics
Hirvensalo, P; Tornio, A; Neuvonen, M; Tapaninen, T; Paile-Hyvärinen, M; Kärjä, V; Männistö, VT; Pihlajamäki, J; Backman, JT; Niemi, M. CLINICAL PHARMACOLOGY AND THERAPEUTICS 2018; 104 1: 158-168. 2017 -
Increased Liver Fatty Acid Uptake Is Partly Reversed and Liver Fat Content Normalized After Bariatric Surgery
Immonen H, Hannukainen JC, Kudomi N, Pihlajamäki J, Saunavaara V, Laine J, Salminen P, Lehtimäki T, Pham T, Iozzo P, Nuutila P. DIABETES CARE 2018; 41 2: 368-371. 2017 -
Identification and characterization of a FOXA2-regulated transcriptional enhancer at a type 2 diabetes intronic locus that controls GCKR expression in liver cells
López Rodríguez M, Kaminska D, Lappalainen K, Pihlajamäki J, Kaikkonen MU, Laakso M. Genome Medicine 9: 63. 2017 -
Effects of Genetic Variants on Carboxylesterase 1 Gene Expression, and Clopidogrel Pharmacokinetics and Antiplatelet Effects
Neuvonen M, Tarkiainen EK, Tornio A, Hirvensalo P, Tapaninen T, Paile-Hyvärinen M, Itkonen MK, Holmberg MT, Kärjä V, Männistö VT, Neuvonen PJ, Pihlajamäki J, Backman JT, Niemi M. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY 2018; 122 3: 341-345. 2017 -
Obstructive sleep apnea: the effect of bariatric surgery after 12 months. A prospective multicenter trial
Peromaa-Haavisto P, Tuomilehto H, Kössi J, Virtanen J, Luostarinen M, Pihlajamäki J, Käkelä P, Victorzon M. Sleep medicine 35: 85-90. 2017 -
Molecular evaluation of vitamin D responsiveness of healthy young adults
Seuter Sabine, Virtanen Jyrki K, Nurmi Tarja, Pihlajamäki Jussi, Mursu Jaakko, Voutilainen Sari, Tuomainen Tomi-Pekka, Neme Antonio, Carlberg Carsten. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 174: 314-321. 2017 -
Interorgan cross talk between fatty acid metabolism, tissue inflammation, and FADS2 genotype in humans with obesity
Vaittinen M, Männistö V, Käkelä P, Ågren J, Tiainen M, Schwab U, Pihlajamäki J. OBESITY (SILVER SPRING, MD.) 25 3: 545-552. 2017 -
Circulating CXCR5+PD-1+ICOS+ Follicular T Helper Cells Are Increased Close to the Diagnosis of Type 1 Diabetes in Children With Multiple Autoantibodi
Viisanen T, Ihantola E-L, Näntö-Salonen K, Hyöty H, Nurminen N, Selvenius J, Juutilainen A, Moilanen L, Pihlajamäki J, Veijola R,Toppari J, Knip M, Ilonen J, Kinnunen T. DIABETES (NY) 66 2: 437-447. 2017 -
Alterations in fatty acid metabolism in response to obesity surgery combined with dietary counseling
Walle P, Takkunen M, Männistö V, Vaittinen M, Käkelä P, Ågren J, Schwab U, Lindström J, Tuomilehto J, Uusitupa M, Pihlajamäki J. NUTRITION AND DIABETES 7 9: e285. 2017 -
Epigenetic alterations in blood mirror age-associated DNA methylation and gene expression changes in human liver
Bysani M, Perfilyev A, de Mello VD, Rönn T, Nilsson E, Pihlajamäki J, Ling C. Epigenomics 2017; 9 2: 105-122. 2016 -
DNA methylation of loci within ABCG1 and PHOSPHO1 in blood DNA is associated with future type 2 diabetes risk
Dayeh T, Tuomi T, Almgren P, Perfilyev A, Jansson PA, de Mello VD, Pihlajamäki J, Vaag A, Groop L, Nilsson E, Ling C. Epigenetics 11 7: 482-488. 2016 -
High perceived stress is associated with unfavorable eating behavior in overweight and obese Finns of working age
Järvelä-Reijonen E, Karhunen L, Sairanen E, Rantala S, Laitinen J, Puttonen S, Peuhkuri K, Hallikainen M, Juvonen K, Myllymäki T, Föhr T, Pihlajamäki J, Korpela R, Ermes M, Lappalainen R, Kolehmainen M. APPETITE 103: 249-258. 2016 -
Regulation of alternative splicing in human obesity loci
Kaminska Dorota, Käkelä Pirjo, Nikkola Elina, Venesmaa Sari, Ilves Imre, Herzig Karl-Heinz, Kolehmainen Marjukka, Karhunen Leila, Kuusisto Johanna, Gylling Helena, Pajukanta Päivi, Laakso Markku, Pihlajamäki Jussi. Obesity 24 10: 2033-2037. 2016 -
Serum plant sterols associate with Gallstone disease independent of weight loss and non-alcoholic fatty liver disease
Käkelä P, Männistö V, Ilves I, Vaittinen M, Tauriainen MM, Eskelinen M, Gylling H, Paajanen H, Pihlajamäki J. OBESITY SURGERY 27 5: 1284-1291. 2016 -
Probiotics modulated gut microbiota suppresses hepatocellular carcinoma growth in mice
Li J, Sung CY, Lee N, Ni Y, Pihlajamäki J, Panagiotou G, El-Nezami H. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 113 9: E1306-E1315. 2016 -
The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent
Mancina Rosellina Margherita, Dongiovanni Paola, Petta Salvatore, Pingitore Piero, Meroni Marica, Rametta Raffaela, Borén Jan, Montalcini Tizian, Pujia Arturo, Wiklund Olov, Hindy George, Spagnuolo Rocco, Motta Benedetta Maria, Pipitone Rosaria Maria, Craxì Antonio, Fargion Silvia, Nobili Valerio, Käkelä Pirjo, Kärjä Vesa, Männistö Ville et al. GASTROENTEROLOGY 150 5: 1219-1230. 2016 -
Rasvamaksa - entä sitten?
Männistö Ville, Pihlajamäki JUssi. DUODECIM 132 18: 1707-1713. 2016 -
A liquid chromatography-tandem mass spectrometry analysis of nine cytochrome P450 probe drugs and their corresponding metabolites in human serum and urine
Puris Elena, Pasanen Markku, Gynther Mikko, Häkkinen Merja R, Pihlajamäki Jussi, Keränen Tapani, Honkakoski Paavo, Raunio Hannu, Petsalo Aleksanteri. ANALYTICAL AND BIOANALYTICAL CHEMISTRY 2017; 409 1: 251-268. 2016 -
Tarvitseeko terve ihminen ravintolisiä?
Schwab U, Pihlajamäki J. DUODECIM 132 24: 2329-34. 2016 -
Sleep of professional athletes: Underexploited potential to improve health and performance
Tuomilehto Henri, Vuorinen Ville-Pekka, Penttilä Elina, Kivimäki Marko, Vuorenmaa Markus, Venojärvi Mika, Airaksinen Olavi, Pihlajamäki Jussi. Journal of Sports Sciences [epub ahead of print 13 May 2016]: 1-7. 2016 -
Association of MBOAT7 gene variant with plasma ALT levels in children: The PANIC study
Viitasalo A, Eloranta A-M, Atalay M, Romeo S, Pihlajamäki J, Lakka TA. PEDIATRIC RESEARCH 80 5: 651-655. 2016 -
Associations of TM6SF2 167K allele with liver enzymes and lipid profile in children: the PANIC Study
Viitasalo Anna, Pihlajamäki Jussi, Paananen Jussi, Atalay Mustafa, Lindi Virpi, Lakka Timo A. PEDIATRIC RESEARCH 79 5: 684-688. 2016 -
Plasma cathepsin D correlates with histological classifications of fatty liver disease in adults and responds to intervention
Walenbergh SM, Houben T, Rensen SS, Bieghs V, Hendrikx T, van Gorp PJ, Oligschlaeger Y, Jeurissen ML, Gijbels MJ, Buurman WA, Vreugdenhil AC, Greve JW, Plat J1, Hofker MH, Kalhan S, Pihlajamäki J, Lindsey P, Koek GH, Shiri-Sverdlov R. Scientific Reports 6: 38278. 2016 -
Fatty acid metabolism is altered in non-alcoholic steatohepatitis independent of obesity
Walle Paula, Takkunen Markus, Männistö Ville, Vaittinen Maija, Lankinen Maria, Kärjä Vesa, Käkelä Pirjo, Ågren Jyrki, Tiainen Mika, Schwab Ursula, Kuusisto Johanna, Laakso Markku, Pihlajamäki Jussi. METABOLISM 65 5: 655-666. 2016 -
Effect of Bariatric Surgery on Adipose Tissue Glucose Metabolism in Different Depots in Patients With or Without Type 2 Diabetes
Dadson Prince, Landini Linda, Helmiö Mika, Hannukainen Jarna C, Immonen Heidi, Honka Miikka-Juhani, Bucci Marco, Savisto Nina, Soinio Minna, Salminen Paulina, Parkkola Riitta, Pihlajamäki Jussi, Iozzo Patricia, Ferrannini Ele, Nuutila Pirjo. DIABETES CARE 2016; 39 2: 292-299. 2015 -
Markers of cholesterol metabolism as biomarkers in predicting diabetes in the Finnish Diabetes Prevention Study
de Mello VDF, Lindström J, Eriksson JG, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Pihlajamäki J, Tuomilehto J, Uusitupa M. NUTRITION, METABOLISM AND CARDIOVASCULAR DISEASES 25 7: 635-642. 2015 -
Statin use and non-alcoholic steatohepatitis in at risk individuals
Dongiovanni Paola, Petta Salvatore, Mannisto Ville, Mancina Rosellina Margherita, Pipitone Rosaria, Karja Vesa, Maggioni Marco, Kakela Pirjo, Wiklund Olov, Mozzi Enrico, Grimaudo Stefania, Kaminska Dorota, Rametta Raffaela, Craxi Antonio, Fargion Silvia, Nobili Valerio, Romeo Stefano, Pihlajamaki Jussi, Valenti Luca. JOURNAL OF HEPATOLOGY 63 3: 705-712. 2015 -
Plasma IL-1 receptor antagonist levels correlate with the development of non-alcoholic steatohepatitis
Hendrikx Tim, Walenbergh Sofie MA, Jeurissen Mike LJ, Houben Tom, van Gorp Patrick J, Lindsey Patrick J, Koek Ger H, Kalhan Satish, Pihlajamäki Jussi, Hofker Marten H, Shiri-Sverdlov Ronit. Biomarkers in Medicine 9 12: 1301-1309. 2015 -
Cross-linking of sodium caseinate-structured emulsion with transglutaminase alters postprandial metabolic and appetite responses in healthy young individuals
Juvonen Kristiina R, Macierzanka Adam, Lille Martina E, Laaksonen David E, Mykkänen Hannu M, Niskanen Leo K, Pihlajamäki Jussi, Mäkelä Kari A, Mills Clare EN, Mackie Alan R, Malcolm Paul, Herzig Karl-Heinz, Poutanen Kaisa S, Karhunen Leila J. BRITISH JOURNAL OF NUTRITION 114 3: 418-429. 2015 -
Plasma fatty acids as predictors of glycaemia and type 2 diabetes
Lankinen Maria A, Stancáková Alena, Uusitupa Matti, Ågren Jyrki, Pihlajamäki Jussi, Kuusisto Johanna, Schwab Ursula, Laakso Markku. DIABETOLOGIA 58 11: 2533-2544. 2015 -
Epigenetic alterations in human liver from subjects with type 2 diabetes in parallel with reduced folate levels
Nilsson Emma, Matte Ashok, Perfilyev Alexander, de Mello Vanessa D, Käkelä Pirjo, Pihlajamäki Jussi, Ling Charlotte. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM [epub ahead of p rint Sep 29, 2015]: -. 2015 -
Prevalence of Obstructive Sleep Apnoea Among Patients Admitted for Bariatric Surgery: A Prospective Multicentre Trial
Peromaa-Haavisto P, Tuomilehto H, Kössi J, Virtanen J, Luostarinen M, Pihlajamäki J, Käkelä P, Victorzon M. OBESITY SURGERY 2016; 26 7: 1384-1390. 2015 -
Dietary polyunsaturated fatty acids and the Pro12Ala polymorphisms of PPARG regulate serum lipids through divergent pathways: a randomized crossover clinical trial
Pihlajamäki Jussi, Schwab Ursula, Kaminska Dorota, Ågren Jyrki, Kuusisto Johanna, Kolehmainen Marjukka, Paananen Jussi, Laakso Markku, Uusitupa Matti. Genes and Nutrition 10 6: 43. 2015 -
Persistent organic pollutants and non-alcoholic fatty liver disease in morbidly obese patients: a cohort study
Rantakokko Panu, Männistö Ville, Airaksinen Riikka, Koponen Jani, Viluksela Matti, Kiviranta Hannu, Pihlajamäki Jussi. ENVIRONMENTAL HEALTH [ONLINE] 14: 79. 2015 -
Gene-diet interaction of a common FADS1 variant with marine polyunsaturated fatty acids for fatty acid composition in plasma and erythrocytes among men
Takkunen Markus J, de Mello Vanessa D, Schwab Ursula S, Kuusisto Johanna, Vaittinen Maija, Ågren Jyrki J, Laakso Markku, Pihlajamäki Jussi, Uusitupa MI. Molecular Nutrition & Food Research 2016; 60 2: 381-389. 2015 -
MFAP5 is Related to Obesity-Associated Adipose Tissue and Extracellular Matrix Remodeling and Inflammation
Vaittinen Maija, Kolehmainen Marjukka, Rydén Mikael, Eskelinen Matti, Wabitsch Martin, Pihlajamäki Jussi, Uusitupa Matti, Pulkkinen Leena. OBESITY (SILVER SPRING, MD.) 23 7: 1371-1378. 2015 -
FADS2 genotype regulates delta-6 desaturase activity and inflammation in human adipose tissue
Vaittinen Maija, Walle Paula, Kuosmanen Emmi, Männistö Ville, Käkelä Pirjo, Ågren Jyrki, Schwab Ursula, Pihlajamäki Jussi. JOURNAL OF LIPID RESEARCH 2016; 57: 56-65. 2015 -
Association of plasma fatty acid composition with plasma irisin levels in normal weight and overweight/obese children
Viitasalo A, Ågren J, Venäläinen T, Pihlajamäki J, Jääskeläinen J, Korkmaz A, Atalay M, Lakka TA. PEDIATRIC OBESITY 2015; 11 4: 299-305. 2015 -
The 148 M allele of the PNPLA3 is associated with plasma irisin levels in a population sample of Caucasian children: The PANIC Study
Viitasalo Anna, Mustafa Atalay, Pihlajamäki Jussi, Jääskeläinen Jarmo, Korkmaz Ayhan, Kaminska Dorota, Lindi Virpi, Lakka Timo A.. METABOLISM 64 7: 793-796. 2015 -
Specific collagen XVIII isoforms promote adipose tissue accrual via mechanisms determining adipocyte number and affect fat deposition
Aikio Mari, Elamaa Harri, Vicente David, Izzi Valerio, Kaur Inderjeet, Seppinen Lotta, Speedy Helen E, Kaminska Dorota, Kuusisto Sanna, Sormunen Raija, Heijasvaara Ritva, Jones Emma L, Muilu Mikko, Jauhiainen Matti, Pihlajamäki Jussi, Savolainen Markku J, Shoulders Carol C, Pihlajaniemi Taina. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111 30: E3043-52. 2014 -
DNA methylation in obesity and type 2 diabetes
de Mello Vanessa Derenji Ferreira, Pulkkinen Leena, Lalli Marianne, Kolehmainen Marjukka, Pihlajamäki Jussi, Uusitupa Matti. Annals of Medicine 46: 103-113. 2014 -
Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease
Dongiovanni Paola, Petta Salvatore, Maglio Cristina, Fracanzani Anna Ludovica, Pipitone Rosaria, Mozzi Enrico, Motta Benedetta Maria, Kaminska Dorota, Rametta Raffaela, Grimaudo Stefania, Pelusi Serena, Montalcini Tiziana, Alisi Anna, Maggioni Marco, Kärjä Vesa, Borén Jan, Käkelä Pirjo, Di Marco Vito, Xing Chao, Nobili Valerio et.al.. HEPATOLOGY Epub ahead of print: -. 2014 -
Effect of bariatric surgery on liver glucose metabolism in morbidly obese diabetic and non-diabetic patients
Immonen H, Hannukainen JC, Iozzo P, Soinio M, Salminen P, Saunavaara V, Borra R, Parkkola R, Mari A, Lehtimäki T, Pham T, Laine J, Kärjä V, Pihlajamäki J, Nelimarkka L, Nuutila P. JOURNAL OF HEPATOLOGY 60 2: 377-383. 2014 -
Healthy Nordic diet downregulates the expression of genes involved in inflammation in subcutaneous adipose tissue in individuals with features of the metabolic syndrome
Kolehmainen Marjukka, Ulven Stine M, Paananen Jussi, de Mello Vanessa, Schwab Ursula, Carlberg Carsten, Myhrstad Mari, Pihlajamäki Jussi, Dungner Elisabeth, Sjölin Eva, Gunnarsdottir Ingibjörg, Cloetens Lieselotte, Landin-Olsson Mona, Akesson Björn, Rosqvist Fredrik, Hukkanen Janne, Herzig Karl-Heinz, Dragsted Lars O, Savolainen Markku J, Brader Lea, Hermansen Kjeld, Risérus Ulf, Thorsdottir Inga,. AMERICAN JOURNAL OF CLINICAL NUTRITION 101 1 (2015): 228-239. 2014 -
The effectiveness and applicability of different lifestyle interventions for enhancing wellbeing: the study design for a randomized controlled trial for persons with metabolic syndrome risk factors and psychological distress
Lappalainen Raimo, Sairanen Essi, Järvelä Elina, Rantala Sanni, Korpela Riitta, Puttonen Sampsa, Kujala Urho M, Myllymäki Tero, Peuhkuri Katri, Mattila Elina, Kaipainen Kirsikka, Ahtinen Aino, Karhunen Leila, Pihlajamäki Jussi, Järnefelt Heli, Laitinen Jaana, Kutinlahti Eija, Saarelma Osmo, Ermes Miikka, Kolehmainen Marjukka. BMC PUBLIC HEALTH 14 310: -. 2014 -
Postprandial glucose metabolism and SCFA after consuming wholegrain rye bread and wheat bread enriched with bioprocessed rye bran in individuals with mild gastrointestinal symptoms
Lappi Jenni, Mykkänen Hannu, Bach Knudsen Knud Erik, Kirjavainen Pirkka, Katina Kati, Pihlajamäki Jussi, Poutanen Kaisa, Kolehmainen Marjukka. NUTRITION JOURNAL 13 104: -. 2014 -
Ketone body production is differentially altered in steatosis and non-alcoholic steatohepatitis in obese humans
Männistö Ville T, Simonen Marko, Hyysalo Jenni, Soininen Pasi, Kangas Antti J, Kaminska Dorota, Matte Ananda K, Venesmaa Sari, Käkelä Pirjo, Kärjä Vesa, Arola Johanna, Gylling Helena, Cederberg Henna, Kuusisto Johanna, Laakso Markku, Yki-Järvinen Hannele, Ala-Korpela Mika, Pihlajamäki Jussi. Liver International 2015; 35 7: 1853-1861. 2014 -
Lipoprotein Subclass Metabolism in Non-Alcoholic Steatohepatitis
Männistö Ville T, Simonen Marko, Soininen Pasi, Tiainen Mika, Kangas Antti J, Kaminska Dorota, Venesmaa Sari, Käkelä Pirjo, Kärjä Vesa, Gylling Helena, Ala-Korpela Mika, Pihlajamäki Jussi. JOURNAL OF LIPID RESEARCH 55: 2676-2684. 2014 -
Sairaalapotilaan vajaaravitsemuksen havaitseminen ja hoito
Orell-Kotikangas Helena, Antikainen Anne, Pihlajamäki Jussi. DUODECIM 130: 2231-8. 2014 -
Lääketieteen ja ravitsemustieteen keinot tukevat toisiaan potilaiden hoidossa
Pihlajamäki Jussi, Schwab Ursula, Aatsinki Milla. DUODECIM 130: 2223-4. 2014 -
Mikä on erikoissairaanhoidon rooli lihavuuden hoidossa?
Pihlajamäki Jussi. SUOMEN LÄÄKÄRILEHTI 69 10: 683. 2014 -
High-fat diet increases tau expression in the brain of T2DM and AD mice independently of peripheral metabolic status
Takalo M, Haapasalo A, Martiskainen H, Kurkinen KM, Koivisto H, Miettinen P, Khandelwal VK, Kemppainen S, Kaminska D, Mäkinen P, Leinonen V, Pihlajamäki J, Soininen H, Laakso M, Tanila H, Hiltunen M. JOURNAL OF NUTRITIONAL BIOCHEMISTRY 25 6: 634-641. 2014 -
Associations of I148M variant in PNPLA3 gene with plasma ALT levels during 2-year follow-up in normal weight and overweight children: the PANIC Study
Viitasalo A, Pihlajamaki J, Lindi V, Atalay M, Kaminska D, Joro R, Lakka TA. PEDIATRIC OBESITY - -[Epub ahead of print]. 2014 -
Link between GIP and osteopontin in adipose tissue and insulin resistance
Ahlqvist E, Osmark P, Kuulasmaa T, Pilgaard K, Omar B, Brøns C, Kotova O, Zetterqvist AV, Stancáková A, Jonsson A, Hansson O, Kuusisto J, Kieffer TJ, Tuomi T, Isomaa B, Madsbad S, Gomez MF, Poulsen P, Laakso M, Degerman E, et al. (including Pihlajamäki J). DIABETES (NY) 62 6: 2088-2094. 2013 -
Non-cholesterol sterol levels predict hyperglycemia and conversion to type 2 diabetes in finnish men
Cederberg H, Gylling H, Miettinen TA, Paananen J, Vangipurapu J, Pihlajamäki J, Kuulasmaa T, Stancáková A, Smith U, Kuusisto J, Laakso M. PLOS ONE [ONLINE] 8 6: e67406. 2013 -
Comparative nontargeted profiling of metabolic changes in tissues and biofluids in high-fat diet-fed Ossabaw pig
Hanhineva K, Barri T, Kolehmainen M, Pekkinen J, Pihlajamäki J, Vesterbacka A, Solano-Aguilar G, Mykkänen H, Dragsted LO, Urban JF, Poutanen K. JOURNAL OF PROTEOME RESEARCH 12: 3980-3992. 2013 -
A population-based study on the prevalence of NASH using scores validated against liver histology
Hyysalo J, Männistö VT, Zhou Y, Arolad J, Kärjä V, Leivonen M, Juut A, Jaser N, Lallukka S, Käkelä P, Venesmaa S, Simonen M, Saltevo J, Moilanen L, Korpi-Hyövalti E, Keinänen-Kiukaanniemi S, Oksa H, Orho-Melander M, Valentik L, Fargionk S, Pihlajamäki J,Peltoneng M, Yki-Järvinena H. JOURNAL OF HEPATOLOGY Available online 12 December 2013: -. 2013 -
Regulation of alternative splicing in obesity and weight loss
Kaminska D, Pihlajamäki J. Adipocyte 2 3: 143-7. 2013 -
Genetic risk score does not predict the outcome of obesity surgery
Käkelä P, Jääskeläinen T, Torpström J, Ilves I, Venesmaa S, Pääkkönen M, Gylling H, Paajanen H, Uusitupa M, Pihlajamäki J. OBESITY SURGERY online 2014 Jan;24(1):128-33.: -. 2013 -
Mahalaukun ohitus lihavuusleikkauksena: yhden keskuksen kymmenen vuoden kokemukset ja seurannan haasteet
Käkelä P, Torpström J, Venesmaa S, Ilves I, Junnila EL, Penttinen K, Martikainen T, Gylling H, Pääkkönen M, Pihlajamäki J. DUODECIM 129 7: 756-764. 2013 -
Association of ketone body levels with hyperglycemia and type 2 diabetes in 9,398 Finnish men
Mahendran Y, Vangipurapu J, Cederberg H, Stancáková A, Pihlajamäki J, Soininen P, Kangas AJ, Paananen J, Civelek M, Saleem NK, Pajukanta P, Lusis AJ, Bonnycastle LL, Morken MA, Collins FS, Mohlke KL, Boehnke M, Ala-Korpela M, Kuusisto J, Laakso M. DIABETES (NY) 62: 3618-3626. 2013 -
Targeting ApoE4/ApoE receptor LRP1 in Alzheimer's disease
Martiskainen H, Haapasalo A, Kurkinen KM, Pihlajamäki J, Soininen H, Hiltunen M. EXPERT OPINION ON THERAPEUTIC TARGETS 17 7: 781-794. 2013 -
Desmosterol in human nonalcoholic steatohepatitis
Simonen M, Männistö V, Leppänen J, Kaminska D, Kärjä V, Venesmaa S, Käkelä P, Kuusisto J, Gylling H, Laakso M, Pihlajamäki J. HEPATOLOGY 58: 976-982. 2013 -
Downregulation of CPPED1 expression improves glucose metabolism in vitro in adipocytes
Vaittinen M, Kaminska D, Käkelä P, Eskelinen M, Kolehmainen M, Pihlajamäki J, Uusitupa M, Pulkkinen L. DIABETES (NY) 62: 3747-3750. 2013 -
Adipose Tissue TCF7L2 Splicing Is Regulated by Weight Loss and Associates With Glucose and Fatty Acid Metabolism
Kaminska D, Kuulasmaa T, Venesmaa S, Käkelä P, Vaittinen M, Pulkkinen L, Pääkkönen M, Gylling H, Laakso M, Pihlajamäki J. DIABETES (NY) 61: 2807-2813. 2012 -
Lihavuuskirurgian aiheet Suomessa ristiriitaiset
Koivukangas V, Juuti A, Salminen P, Pihlajamäki J. SUOMEN LÄÄKÄRILEHTI 67 23: 1800-1800. 2012 -
Impact of Obesity and Associated Diseases on Outcome After Laparoscopic Cholecystectomy
Paajanen, Hannu; Käkelä, Pirjo; Suuronen, Satu; Paajanen, Juuso; Juvonen, Petri; Pihlajamäki, Jussi. SURGICAL LAPAROSCOPY, ENDOSCOPY & PERCUTANEOUS TECHNIQUES 22 6: 509-513. 2012 -
Vaikeasti sairaan ravitsemus
Pihlajamäki J, Gylling H, Schwab U. DUODECIM 128 17: 1733-4. 2012 -
Serum interleukin 1 receptor antagonist as anindependent marker of non-alcoholic steatohepatitis in humans
Pihlajamäki J, Kuulasmaa T, Kaminska D, Simonen M, Kärjä V, Grönlund S, Käkelä P, Pääkkönen M, Kainulainen S, Punnonen K, Kuusisto J, Gylling H, Laakso M. JOURNAL OF HEPATOLOGY 56 3: 663-670. 2012 -
Response to Brosch et al.
Pihlajamäki J, Lerin C, Kaminska D, Venesmaa S, Itkonen P, Boes T, Floss T, Schroeder J, Dearie F, Crunkhorn S, Burak F, Jimenez-Chillaron JC, Kuulasmaa T, Miettinen P, Park PJ, Nasser I, Zhao Z, Zhang Z, Xu Y, Wurst W et.al.. Cell Metabolism 15 3: 267-269. 2012 -
Conjugated Bile Acids Associate with Altered Rates of Glucose and Lipid Oxidation after Roux-en-Y Gastric Bypass
Simonen M, Dali-Youcef N, Kaminska D, Venesmaa S, Käkelä P, Pääkkönen M, Hallikainen M, Kolehmainen M, Uusitupa M, Moilanen L, Laakso M, Gylling H, Patti ME, Auwerx J, Pihlajamäki J. OBESITY SURGERY 22 9: 1473-1480. 2012 -
Hyperglycemia and a common variant of GCKR are associated with the levels of eight amino acids in 9,369 Finnish men
Stancáková Alena, Civelek Mete, Saleem Niyas K, Soininen Pasi, Kangas Antti J, Cederberg Henna, Paananen Jussi, Pihlajamäki Jussi, Bonnycastle Lori L, Morken Mario A, Boehnke Michael, Pajukanta Päivi, Lusis Aldons J, Collins Francis S, Kuusisto Johanna, Ala-Korpela Mika, Laakso Markku. DIABETES (NY) 61: 1895-1902. 2012 -
Lihavuusleikkauksen jälkeen
Torpström, Jaana; Käkelä, Pirjo; Pihlajamäki, Jussi. DIABETES JA LÄÄKÄRI 41 1: 29-33. 2012 -
PKCδ regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans
Bezy Olivier, Tran Thien T, Pihlajamäki Jussi, Suzuki Ryo, Emanuelli Brice, Winnay Jonathan, Mori Marcelo A, Haas Joel, Biddinger Sudha B, Leitges Michael, Goldfine Allison B, Patti Elizabeth, King George L, Kahn C Ronald. 2011. PKCδ regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans JOURNAL OF CLINICAL INVESTIGATION 121: 2504- 2011 -
Glomerular filtration rate and parathyroid hormone are associated with 1,25-dihydroxyvitamin D in men without chronic kidney disease
Karhapää P, Pihlajamäki J, Pörsti I, Kastarinen M, Mustonen J, Niemelä O, Tuomi H, Kuusisto J.. JOURNAL OF INTERNAL MEDICINE 2011: online. 2011 -
Serum interleukin 1 receptor antagonist as an independent marker of non-alcoholic steatohepatitis in humans
Pihlajamäki J, Kuulasmaa T, Kaminska D, Simonen M, Kärjä V, Grönlund S, Käkelä P, Pääkkönen M, Kainulainen S, Punnonen K, Kuusisto J, Gylling H, Laakso M. JOURNAL OF HEPATOLOGY 56 3: 663-670. 2011 -
Expression of the Splicing Factor Gene SFRS10 Is Reduced in Human Obesity and Contributes to Enhanced Lipogenesis
Pihlajamäki Jussi, Lerin Carles, Itkonen Paula, Boes Tanner, Thomas Floss Thomas, Schroeder Joshua, Dearie Farrell, Crunkhorn Sarah, Burak Furkan, Jimenez-Chillaron Josep C., Kuulasmaa Tiina, Miettinen Pekka, Park Peter J., Nasser Imad, Zhao Zhenwen, Zhang Zhaiyi, Xu Yan, Wurst Wolfgang, Ren Hongmei, Morris Andrew J.Stamm Stefan, Goldfine Allison B., Laakso Markku, Patti Mary Elizabeth. Cell Metabolism 14 2: 208-218. 2011 -
Association of indices of liver and adipocyte insulin resistance with 19 confirmed susceptibility loci for type 2 diabetes in 6,733 non-diabetic Finnish men
Vangipurapu J, Stancakova A, Pihlajamäki J, Kuulasmaa TM, Kuulasmaa T, Paananen J, Kuusisto J, Ferrannini E, Laakso M. DIABETOLOGIA 54: 563-571. 2011 -
Insulin sensitivity regulates cholesterol metabolism to a greater extent than obesity. Lessons from the METSIM study.
Gylling H, Hallikainen M, Pihlajamaki J, Simonen P, Kuusisto J, Laakso M, Miettinen TA.. JOURNAL OF LIPID RESEARCH 51: 2422-2427. 2010 -
Diverse associations of 25-hydroxyvitamin D and 1,25-dihydroxy-vitamin D with dyslipidaemias
Karhapää P, Pihlajamäki J, Pörsti I, Kastarinen M, Mustonen J, Niemelä P, Kuusisto J. JOURNAL OF INTERNAL MEDICINE 268: 604-610. 2010 -
Cholesterol absorption decreases after Roux-en-Y gastric bypass but not after gastric banding
Pihlajamäki J, Grönlund S, Simonen M, Käkelä P, Moilanen L, Pääkkönen M, Pirinen E, Kolehmainen M, Kärjä V, Kainulainen S, Uusitupa M, Alhava E, Miettinen TA, Gylling H. Metabolism: clinical and experimental 59: 866-872. 2010 -
Activated polyamine catabolism leads to low cholesterol levels by enhancing bile acid synthesis
Pirinen E, Gylling H, Itkonen P, Yaluri N, Heikkinen S, Pietilä M, Kuulasmaa T, Tusa M, Cerrada-Gimenez M, Pihlajamäki J, Alhonen L, Jänne J, Miettinen TA & Laakso M. AMINO ACIDS 38: 549-560. 2010 -
Changes in cytokine levels during acute hyperinsulinemia in offspring of type 2 diabetic subjects
Ruotsalainen E, Stancakova A, Vauhkonen I, Salmenniemi U, Pihlajamäki J, Punnonen K, Laakso M. ATHEROSCLEROSIS 210: 536-541. 2010 -
SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity
Rutanen J, Yaluri N, Modi S, Pihlajamäki J, Vänttinen M, Itkonen P, Kainulainen S, Yamamoto H, Lagouge M, ..., Laakso M. DIABETES (NY) 59: 829-835. 2010 -
The metabolism of plant sterols is disturbed in postmenopausal women with coronary artery disease
Gylling H, Hallikainen M, Rajaratnam RA, Simonen P, Pihlajamäki J, Laakso M, Miettinen TA. METABOLISM: CLINICAL AND EXPERIMENTAL 58: 401-407. 2009 -
The Pro12Ala polymorphism of the PPARgamma2 gene is associated with hepatic glucose uptake during hyperinsulinwmia in subjects with type 2 diabetes mellitus
Honka M-J, Vänttinen M, Iozzo P, Virtanen KA, Lautamäki R, Hällsten K, Borra RJH, Takala T, Viljanen APM, Kemppainen J, Pihlajamäki J, Knuuti J, Nuutila P, Laakso M. METABOLISM: CLINICAL AND EXPERIMENTAL 58: 541-546. 2009 -
High circulating levels of RBP4 and mRNA levels of aP2, PGC-1alpha and UCP-2 predict improvement in insulin sensitivity following pioglitazone treatment of drug-naïve type 2 diabetic subjects
Hammerstedt A, Pihlajamäki J, Graham TE, Kainulainen S, Kahn BB, Laakso M, Smith U. JOURNAL OF INTERNAL MEDICINE 263: 440-449. 2008 -
Markes of endothelial dysfunction and low-grade inflammation are associated in the offspring of type 2 diabetic subjects
Ruotsalainen E, Vauhkonen I, Salmenniemi U, Pihlajamäki J, Punnonen K, Kainulainen S, Jalkanen S, Salmi M, Laakso M. ATHEROSCLEROSIS 197: 271-277. 2008 -
Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance
Stancáková A, Pihlajamäki J, Kuusisto J, Stefan N, Fritsche A, Häring H, Andreozzi F, Succurro E, Sesti G, Boesgaard TW, Hansen T, Pedersen O, Jansson PA, Hammarstedt A, Smith U, Laakso M, for the EUGENE2 Consortium. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 93 5: 1924-1930. 2008 -
Cholesterol synthesis prevails over absorption in metabolic syndrome
Gylling H, Hallikainen M, Kolehmainen M, Toppinen L, Pihlajamäki J, Mykkänen H, Ågren JJ, Rauramaa R, Laakso M, Miettinen TA. TRANSLATIONAL RESEARCH 149: 310-316. 2007 -
Serum adipokines are associated with cholesterol metabolism in the metabolic syndrome
Hallikainen M, Kolehmainen M, Schwab U, Laaksonen DE, Niskanen L, Rauramaa R, Pihlajamäki J, Uusitupa M, Miettinen TA, Gylling H, Kolehmainen M. CLINICA CHIMICA ACTA (AMSTERDAM) 383: 126-132. 2007 -
Single nucleotide polymorphisms of the MCHR1 gene do not affect metabolism in humans
Rutanen J, Pihlajamäki J, Vänttinen M, Salmenniemi U, Ruotsalainen E, Kuulasmaa T, Kainulainen S, Kuusisto J, Laakso M. OBESITY (SILVER SPRING, MD.) 15: 2902-2907. 2007 -
Single nucleotide polymorphisms of the melanocortin-3 receptor gene are associated with substrate oxidation and first-phase insulin secretion in offspring of type 2 diabetic subjects
Rutanen J, Pihlajamäki J, Vänttinen M, Salmenniemi U, Ruotsalainen E, Kuulasmaa T, Kainulainen S, Laakso M, Laakso M. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 92: 1112-1117. 2007 -
Cholesterol metabolism and non-cholesterol sterol distribution in lipoproreins of type 1 diabetes: The effect of improved glycemic control
Sittiwet C, Gylling H, Hallikainen M, Pihlajamäki J, Moilanen L, Laaksonen DE, Niskanen L, Ågren JJ, Laakso M, Miettinen TA. ATHEROSCLEROSIS 194: 465-472. 2007 -
Endothelial function in hypercholesterolemic subjects: Effects of plant stanol and sterol esters
Hallikainen M, Lyyra-Laitinen T, Laitinen T, Ågren JJ, Pihlajamäki J, Rauramaa R, Miettinen TA, Gylling H. ATHEROSCLEROSIS 188: 425-432. 2006 -
Visfatin is an adipokine, but it is not regulated by Thiazolidinediones
Hammarstedt A, Pihlajamäki J, Sopasakis VR, Gogg S, Jansson P-A, Laakso M, Smith U. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 91: 1181-1184. 2006 -
HLA genotyping is useful in the evaluation of the risk for coelic disease in the 1st-degree relatives of patients with coeliac disease
Karinen H, Kärkkäinen P, Pihlajamäki J, Janatuinen E, Heikkinen M, Julkunen R, Kosma V-M, Naukkarinen A, Laakso M, Laakso M. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY 41: 1299-1304. 2006 -
Gene dose effect of the DQB1*0201 allele contributes to severity of coeliac disease
Karinen H, Kärkkäinen P, Pihlajamäki J, Janatuinen E, Heikkinen M, Julkunen R, Kosma V-M, Naukkarinen A, Laakso M. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY 41: 191-199. 2006 -
Association analysis of peroxisome proliferator-activated receptor gamma polymorphisms and late onset Alzhimer¿s disease in the Finnish population
Koivisto AM, Helisalmi S, Pihlajamäki J, Hiltunen M, Koivisto K, Moilanen L, Kuusisto J, Helkala E-L, Hänninen T, Kervinen K, Kesäniemi YA, Laakso M, Soininen H, Koivisto AM, Helisalmi S, Hiltunen M, Soininen H, Laakso M. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS 22: 449-453. 2006 -
Visceral obesity is associated with high levels of serum squalene
Peltola P, Pihlajamäki J, Koutnikova H, Ruotsalainen E, Salmenniemi U, Vauhkonen I, Kainulainen S, Gylling H, Miettinen TA, Auwerx J, Laakso M, Laakso M. OBESITY (SILVER SPRING, MD.) 14: 1155-1163. 2006 -
Common polymorphisms of calpain-10 are associated with abdominal obesity in subjects at high risk of type 2 diabetes
Pihlajamäki J, Salmenniemi U, Vänttinen M, Ruotsalainen E, Kuusisto J, Vauhkonen I, Kainulainen S, Ng MCY, Cox NJ, Bell CI, Laakso M, Laakso M. DIABETOLOGIA 49: 1560-1566. 2006 -
Changes in inflammatory cytokines are related to impaired glucose tolerance in offspring of type 2 diabetic subjects
Ruotsalainen E, Salmenniemi U, Vauhkonen I, Pihlajamäki J, Punnonen K, Kainulainen S, Laakso M. DIABETES CARE 29 12: 2714-2720. 2006 -
Genetics and phenotypic characteristics of autosomal dominant polycystic kidney disease in Finns
Peltola P, Lumiaho A, Miettinen R, Pihlajamäki J, Sandford R, Laakso M, Laakso M. JOURNAL OF MOLECULAR MEDICINE 83: 638-646. 2005 -
Haplotypes of PPARGC1A are associated with glucose tolerance, body mass index and insulin sensitivity in offpring of patients with type 2 diabetes
Pihlajamäki J, Kinnunen M, Ruotsalainen E, Salmenniemi U, Vauhkonen I, Kuulasmaa T, Kainulainen S, Laakso M, Laakso M. DIABETOLOGIA 48: 1331-1334. 2005 -
High amount of visceral fat mass is associated with multiple metabolic changes in offspring of type 2 diabetic patients
Salmenniemi U, Ruotsalainen E, Vänttinen M, Vauhkonen I, Pihlajamäki J, Kainulainen S, Punnonen K, Laakso M. INTERNATIONAL JOURNAL OF OBESITY 29: 1464-1470. 2005 -
Association of adiponectin level and variants in the adiponectin gene with glucose metabolism, energy expenditure, and cytokines in offspring of type 2 diabetic patients
Salmenniemi U, Zacharova J, Ruotsalainen E, Vauhkonen I, Pihlajamäki J, Kainulainen S, Punnonen K, Laakso M, Laakso M. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 90: 4216-4223. 2005 -
Single nucleotide polymorphisms in the peroxisome proliferator-activated receptor delta gene are associated with skeletal muscle glucose uptake
Vänttinen M, Nuutila P, Kuulasmaa T, Pihlajamäki J, Hällsten K, Virtanen KA, Lautamäki R, Peltoniemi P, Takala T, Viljanen APM, Knuuti J, Laakso M, Laakso M. DIABETES (NY) 54: 3587-3591. 2005 -
The effect of the Ala12 allele of the peroxisome proliferator-activated receptor-gamma2 gene on skeletal muscle glucose uptake depends on obesity: a positron emission tomography study
Vänttinen M, Nuutila P, Pihlajamäki J, Hällsten K, Virtanen KA, Lautamäki R, Peltoniemi P, Kemppainen J, Takala T, Viljanen APM, Knuuti J, Laakso M, Laakso M. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 90: 4249-4254. 2005 -
Polymorphisms in the ABCG5 and ABCG8 genes associate with cholesterol absorbtion and insulin sensitivity
Gylling H, Hallikainen M, Pihlajamäki J, Ågren J, Laakso M, Rajaratnam RA, Rauramaa R, Miettinen TA, Laakso M. JOURNAL OF LIPID RESEARCH 45: 1660-1665. 2004 -
Common polymorphisms in the genes regulating the early insulin signalling pathway: effects on weight change and the conversion from impaired glucose tolerance to Type 2 diabetes
Laukkanen O, Pihlajamäki J, Lindström J, Eriksson J, Valle TT, Hämaläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Uusitupa M, Laakso M, for the Finnish Diabetes Prevention Study Group, Laakso M. DIABETOLOGIA 47: 871-877. 2004 -
Polymorphisms of the SUR1 (ABCC8) and Kir6.2 (KCNJ11) genes predict the conversion from impaired glucose tolerance to type 2 diabetes. The Finnish diabetes prevention study
Laukkanen O, Pihlajamäki J, Lindström J, Eriksson J, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Uusitupa M, Laakso M, for the Finnish diabetes prevention study group. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 89: 6286-6290. 2004 -
Insulin resistance is associated with increased cholesterol synthesis and decreased cholesterol absorption in normoglycemic men
Pihlajamäki J, Gylling H, Miettinen TA, Laakso M. JOURNAL OF LIPID RESEARCH 45: 507-512. 2004 -
The Pro12Ala polymorphism of the PPARgamma2 gene regulates weight from birth to adulthood
Pihlajamäki J, Vanhala M, Vanhala P, Laakso M, Laakso M. OBESITY (SILVER SPRING, MD.) 12 2: 187-190. 2004 -
Genomewide search and association studies in a Finnish celiac disease population: identification of a novel locus and replication of HLA and CTLA4 loci
Rioux JD, Karinen H, Kocher K, McMahon SG, Kärkkäinen P, Janatuinen E, Heikkinen M, Julkunen R, Pihlajamäki J, Naukkarinen A, Kosma V-M, Daly MJ, Lander ES, Laakso M, Laakso M. AMERICAN JOURNAL OF MEDICAL GENETICS. PART A 130: 345-350. 2004 -
The Val103Ile polymorphism of melanocortin-4 receptor regulates energy expenditure and weight gain
Rutanen J, Pihlajamäki J, Karhapää P, Vauhkonen I, Kuusisto J, Moilanen Mykkänen L, Laakso M, Laakso M. OBESITY (SILVER SPRING, MD.) 12: 1060-1066. 2004 -
Multiple abnormalities in glucose and energy metabolism and coordinated changes in levels of adiponectin, cytokines, and adhesion molecules in subjects with metabolic syndrome
Salmenniemi U, Ruotsalainen E, Pihlajamäki J, Vauhkonen I, Kainulainen S, Punnonen K, Vanninen E, Laakso M. CIRCULATION 110: 3842-3848. 2004 -
Aldose reductase gene polymorphisms and peripheral nerve function in patients with type 2 diabetes
Sivenius K, Pihlajamäki J, Partanen J, Niskanen L, Laakso M, Uusitupa M. DIABETES CARE 27: 2021-2026. 2004 -
The G-250A promoter polymorphism of the hepatic lipase gene predicts the conversion from impaired glucose tolerance to type 2 diabetes mellitus: the Finnish Diabetes Prevention Study
Todorova B, Kubaszek A, Pihlajamäki J, Lindström J, Eriksson J, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Uusitupa M, Laakso M, Laakso M. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 89 5: 2019-2023. 2004 -
Promoter polymorphisms -359T/C and -303A/G of the catalytic subunit p110beta gene of human phosphatidylinositol 3-kinase are not associated with insulin secretion or insulin sensitivity in Finnish subjects
Kossila M, Pihlajamäki J, Kärkkäinen P, Miettinen R, Kekäläinen P, Vauhkonen I, Ylä-Herttuala S, Laakso M, Laakso M. DIABETES CARE 26: 179-182. 2003 -
The K121Q polymorphism of the PC-1 gene is associated with insulin resistance but not with dyslipidemia
Kubaszek A, Pihlajamäki J, Karhapää P, Vauhkonen I, Laakso M, Laakso M. DIABETES CARE 26: 464-467. 2003 -
Promoter polymorphisms of the TNF-alfa (G-308A) and IL-6 (C-174G) genes predict the conversion from impaired glucose tolerance to type 2 diabetes. The Finnish Diabetes Prevention Study
Kubaszek A, Pihlajamäki J, Komarovski V, Lindi V, Lindström J, Eriksson J, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Uusitupa M, Laakso M, Laakso M. DIABETES (NY) 52: 1872-1876. 2003 -
The C-174G promoter polymorphism of the IL-6 gene affects energy expenditure and insulin sensitivity
Kubaszek A, Pihlajamäki J, Punnonen K, Karhapää P, Vauhkonen I, Laakso M, Laakso M. DIABETES (NY) 52: 558-561. 2003 -
Progression of kidney disease varies between families with defects in the polycystic kidney disease type 1 gene in eastern Finland
Lumiaho A, Ikäheimo R, Pihlajamäki J, Miettinen R, Niemitukia L, Vanninen R, Lampainen E, Laakso M. SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY 37: 352-358. 2003 -
Insulin resistance is related to left ventricular hyperthrophy in patients with polycystic kidney disease type 1
Lumiaho A, Pihlajamäki J, Hartikainen J, Ikäheimo R, Miettinen R, Niemitukia L, Lampainen E, Laakso M. AMERICAN JOURNAL OF KIDNEY DISEASES 41 6: 1219-1224. 2003 -
The Leu7Pro polymorphism of the neuropeptide Y gene regulates free fatty acid metabolism
Pihlajamäki J, Karhapää P, Vauhkonen I, Kekäläinen P, Kareinen A, Viitanen L, Pesonen U, Kallio J, Uusitupa M, Laakso M. METABOLISM: CLINICAL AND EXPERIMENTAL 52 5: 643-646. 2003 -
The effect of the -308A allele of the TNF-alfa gene on insulin action is dependent on obesity
Pihlajamäki J, Ylinen M, Karhapää P, Vauhkonen I, Laakso M. OBESITY (SILVER SPRING, MD.) 11 7: 912-917. 2003 -
Mutations in the cardiac myosin-binding protein C gene are the predominant cause of familial hypertrophic cardiomyopathy in eastern Finland
Jääskeläinen P, Kuusisto J, Miettinen R, Kärkkäinen P, Kärkkäinen S, Heikkinen S, Peltola P, Pihlajamäki J, Vauhkonen I, Laakso M. JOURNAL OF MOLECULAR MEDICINE 80: 412-422. 2002 -
Genetic influences contributing to LDL particle siz in familial combined hyperlipidaemia
Vakkilainen J, Pajukanta P, Cantor RM, Nuotio IO, Lahdenperä S, Ylitalo K, Pihlajamäki J, Kovanen PT, Laakso M, Viikari JSA, Peltonen L, Taskinen M-R. EUROPEAN JOURNAL OF HUMAN GENETICS 10: 547-552. 2002 -
A major gene effect on fasting insulin and insulin sensitivity in familial combined hyperlipidemia
Pihlajamäki J, Austin M, Edwards K, Laakso M. DIABETES (NY) 50: 2396-2401. 2001 -
The hormone sensitive lipase gene in familial combined hyperlipidemia and insulin resistance
Pihlajamäki J, Valve R, Karjalainen L, Karhapää P, Vauhkonen I, Laakso M. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION 31: 302-308. 2001 -
Association of angiotensin converting enzyme and plasminogen activator inhibitor-1 promoter gene polymorphisms with features of the insulin resistance syndrome in patients with premature coronary heart disease
Viitanen L, Pihlajamäki J, Halonen P, Lehtonen M, Kareinen A, Lehto S, Laakso M. ATHEROSCLEROSIS 157: 57-64. 2001 -
Apolipoprotein E gene promoter (-219G/T) polymorphism is associated with premature coronary heart disease
Viitanen L, Pihlajamäki J, Miettinen R, Kärkkäinen P, Vauhkonen I, Halonen P, Kareinen A, Lehto S, Laakso M. JOURNAL OF MOLECULAR MEDICINE 79: 732-737. 2001 -
Impaired free fatty acid suppression during hyperinsulinemia is a characteristic finding in familial combined hyperlipidemia, but insulin resistance is observed only in hypertriglyceridemic paitients
Pihlajamäki J, Karjalainen L, Karhapää P, Vauhkonen I, Laakso M. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 20: 164-170. 2000 -
G-250A substitution in promoter of hepatic lipase gene is associated with dyslipidemia and insulin resistance in healthy control subjects and in members of families with familial combined hyperlipidemia
Pihlajamäki J, Karjalainen L, Karhapää P, Vauhkonen I, Taskinen M-R, Deeb SS, Laakso M. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 20: 1789-95. 2000 -
The Pro12Ala substitution in the peroxisome proliferator activated receptor gamma 2 is associated with an insulin-sensitive phenotype in families with familial combined hyperlipidemia and in nondiabetic elderly subjects with d
Pihlajamäki J, Miettinen R, Valve R, Karjalainen L, Mykkänen L, Kuusisto J, Deeb S, Auwerx J, Laakso M. ATHEROSCLEROSIS 151: 567-574. 2000 -
Sulfonylurea receptor 1 gene variants are associated with gestational diabetes and type 2 diabetes but not with altered secretion of insulin
Rissanen J, Markkanen A, Kärkkäinen P, Pihlajamäki J, Kekäläinen P, Mykkänen L, Kuusisto J, Karhapää P, Niskanen L, Laakso M. DIABETES CARE 23: 70-73. 2000 -
Genomewide scan for familial combined hyperlipidemia genes in Finnish families, suggesting multiple susceptibility loci influencing triglyceride, cholesterol, and apolipoprotein B levels
Pajukanta P, Terwilliger JD, Perola M, Hiekkalinna T, Nuotio I, Ellonen P, Parkkonen M, Hartiala J, Ylitalo K, Pihlajamäki J, Porkka K, Laakso M, Viikari J, Ehnholm C, Taskinen M-R, Peltonen L. AMERICAN JOURNAL OF HUMAN GENETICS 64: 1453-1463. 1999 -
Two polymorphisms in the peroxisome proliferator-activated receptor-gamma gene are associated with severe overweight among obese women
Valve R, Sivenius K, Miettinen R, Pihlajamäki J, Rissanen A, Deeb SS, Auwerx J, Uusitupa M, Laakso M. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 84 10: 3708-3712. 1999 -
A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity
Deeb SS, Fajas L, Nemoto M, Pihlajamäki J, Mykkänen L, Kuusisto J, Laakso M, Fujimoto W, Auwerx J. NATURE GENETICS 20: 284-287. 1998 -
The cardiac beta-myosin heavy chain gene is not the predominant gene for hypertrophic cardiomyopathy in the Finnish population
Jääskeläinen P, Soranta M, Miettinen R, Saarinen L, Pihlajamäki J, Silvennoinen K, Tikanoja T, Laakso M, Kuusisto J. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 32 6: 1709-1716. 1998 -
Impaired insulin-stimulated glucose oxidation and free fatty acid suppression in patients with familial combined hyperlipidemia: a precursor defect for dyslipidemia?
Karjalainen L, Pihlajamäki J, Karhapää P, Laakso M. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 18: 1548-1553. 1998 -
Linkage of familial combined hyperlipidaemia to chromosome 1q21-q23
Pajukanta P, Nuotio I, Terwilliger JD, Porkka KVK, Ylitalo K, Pihlajamäki J, Suomalainen AJ, Syvänen A-C, Lehtimäki T, Viikari JSA, Laakso M, Taskinen M-R, Ehnholm C, Peltonen L. NATURE GENETICS 18: 369-373. 1998 -
Different regulation of free fatty acid levels and glucose oxidation by the Trp64Arg polymorphism of the beta3-adrenergic receptor gene and the promoter variant (A-3826G) of the uncoupling protein 1 gene in familial combined hyperlipidemia
Pihlajamäki J, Rissanen J, Valve R, Heikkinen S, Karjalainen L, Laakso M. METABOLISM: CLINICAL AND EXPERIMENTAL 47 11: 1397-1402. 1998 -
Codon 54 polymorphism of the human intestinal fatty acid binding protein 2 gene is associated with dyslipidemias but not with insulin resistance in patients with familial combined hyperlipidemia
Pihlajamäki J, Rissanen J, Heikkinen S, Karjalainen L, Laakso M. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 17: 1039-1044. 1997 -
The trp64arg polymorphism of the beta3-adrenergic receptor gene
Rissanen J, Kuopusjärvi M, Pihlajamäki J, Sipiläinen R, Heikkinen S, Vanhala M, Kekäläinen P, Kuusisto J, Laakso M. DIABETES CARE 20 8: 1319-1323. 1997 -
The ala54thr polymorphism of the fatty acid binding protein 2 gene does not influence insulin sensitivity in Finnish nondiabetic and NIDDM subjects
Rissanen J, Pihlajamäki J, Heikkinen S, Kekäläinen P, Kuusisto J, Laakso M. DIABETES (NY) 46: 711-712. 1997 -
New variants in the glycogen synthase gene (GIn71His, Met416Val) in patients with NIDDM from eastern Finland
Rissanen J, Pihlajamäki J, Heikkinen S, Kekäläinen P, Mykkänen L, Kuusisto J, Kolle A, Laakso M. DIABETOLOGIA 40: 1313-1319. 1997