Kati-Sisko Vellonen

Comprehensive ocular and systemic pharmacokinetics of dexamethasone after subconjunctival and intravenous injections in rabbits

Valtari, Annika; Posio, Susanna; Toropainen, Elisa; Balla, Anusha; Puranen, Jooseppi; Sadeghi, Amir; Ruponen, Marika; Ranta, Veli-Pekka; Vellonen, Kati-Sisko; Urtti, Arto; del Amo, Eva M. 2024. European journal of pharmaceutics and biopharmaceutics. 198:

Aldehyde oxidase 1 activity and protein expression in human, rabbit, and pig ocular tissues

Hammid, Anam; Fallon, John K; Vellonen, Kati Sisko; Lassila, Toni; Reinisalo, Mika; Urtti, Arto; Gonzalez, Francisco; Tolonen, Ari; Smith, Philip C; Honkakoski, Paavo. 2023. European journal of pharmaceutical sciences. 191: . 106603

Altering distribution profile of palbociclib by its prodrugs

Järvinen, Juulia; Montaser, Ahmed B; Adla, Santosh Kumar; Leppänen, Jukka; Lehtonen, Marko; Vellonen, Kati-Sisko; Laitinen, Tuomo; Jalkanen, Aaro; Elmquist, William F; Timonen, Juri; Huttunen, Kristiina M; Rautio, Jarkko. 2023. European journal of pharmaceutical sciences. 2024; 192:

Comparison of barrier properties of outer blood-retinal barrier models - Human stem cell-based models as a novel tool for ocular drug discovery

Hellinen, Laura; Hongisto, Heidi; Ramsay, Eva; Kaarniranta, Kai; Vellonen, Kati-Sisko; Skottman, Heli; Ruponen, Marika. 2023. European journal of pharmaceutics and biopharmaceutics. 184: 181-188

Functional Characterization of Six SLCO1B1 (OATP1B1) Variants Observed in Finnish Individuals with a Psychotic Disorder

Häkkinen, Katja; Kiander, Wilma; Kidron, Heidi; Lähteenvuo, Markku; Urpa, Lea; Lintunen, Jonne; Vellonen, Kati Sisko; Auriola, Seppo; Holm, Minna; Lahdensuo, Kaisla; Kampman, Olli; Isometsä, Erkki; Kieseppä, Tuula; Lönnqvist, Jouko; Suvisaari, Jaana; Hietala, Jarmo; Tiihonen, Jari; Palotie, Aarno; Ahola-Olli, Ari V.; Niemi, Mikko. 2023. Molecular pharmaceutics. 20: 1500-1508

In vitro identification of decreased function phenotype ABCG2 variants

Suominen, Laura; Sjöstedt, Noora; Vellonen, Kati-Sisko; Gynther, Mikko; Auriola, Seppo; Kidron, Heidi. 2023. European journal of pharmaceutical sciences. 188:

Mass spectrometry in ocular drug research

del Amo, Eva M.; Vellonen, Kati‐Sisko; Urtti, Arto; Terasaki, Tetsuya; Hammid, Anam; Honkakoski, Paavo; Auriola, Seppo. 2023. Mass spectrometry reviews. [First published: 02 August 2023]: 1-32

A Novel Ferroptosis Inhibitor UAMC-3203, a Potential Treatment for Corneal Epithelial Wound

Balla, Anusha; Tran, Bao; Valtari, Annika; Steven, Philipp; Scarpellini, Camilla; Augustyns, Koen; Urtti, Arto; Vellonen, Kati-Sisko; Ruponen, Marika. 2022. Pharmaceutics. 2023; 15:

Functional in vitro characterization of SLCO1B1 variants and simulation of the clinical pharmacokinetic impact of impaired OATP1B1 function.

Wilma, Kiander; Noora, Sjöstedt; Riikka, Manninen; Liina, Jaakkonen; Kati-Sisko, Vellonen; Mikko, Neuvonen; Mikko, Niemi; Seppo, Auriola; Heidi, Kidron. 2022. European journal of pharmaceutical sciences. 176:

Retraction: Hellinen et al. Drug Flux across RPE Cell Models: The Hunt for an Appropriate Outer Blood–Retinal Barrier Model for Use in Early Drug Discovery. Pharmaceutics 2020, 12, 176

Hellinen, Laura; Hongisto, Heidi; Ramsay, Eva; Kaarniranta, Kai; Vellonen, Kati-Sisko; Skottman, Heli; Ruponen, Marika. 2022. Pharmaceutics. 14: 595

Understanding dexamethasone kinetics in the rabbit tear fluid: Drug release and clearance from solution, suspension and hydrogel formulations

Balla, Anusha; Ruponen, Marika; Valtari, Annika; Toropainen, Elisa; Tuomainen, Marjo; Alvarez-Lorenzo, Carmen; del Amo, Eva M.; Urtti, Arto; Vellonen, Kati-Sisko. 2022. European journal of pharmaceutics and biopharmaceutics. 172: 53-60

Biopharmaceutics of Topical Ophthalmic Suspensions: Importance of Viscosity and Particle Size in Ocular Absorption of Indomethacin

Toropainen, Elisa; Fraser-Miller, Sara J; Novakovic, Dunja; Del Amo, Eva M; Vellonen, Kati-Sisko; Ruponen, Marika; Viitala, Tapani; Korhonen, Ossi; Auriola, Seppo; Hellinen, Laura; Reinisalo, Mika; Tengvall, Unni; Choi, Stephanie; Absar, Mohammad; Strachan, Clare; Urtti, Arto. 2021. Pharmaceutics. 13: 452

Ocular pharmacokinetics of atenolol, timolol and betaxolol cocktail: tissue exposures in the rabbit eye

Fayyaz, Anam; Vellonen, Kati-Sisko; Ranta, Veli-Pekka; Toropainen, Elisa; Reinisalo, Mika; Valtari, Annika; Puranen, Jooseppi; D'Amico Ricci, Giuseppe; Heikkinen, Emma M.; Gardner, Iain; Ruponen, Marika; Urtti, Arto; Jamei, Masoud; del Amo, Eva M. 2021. European journal of pharmaceutics and biopharmaceutics. 166: 155-162

Partitioning and Spatial Distribution of Drugs in Ocular Surface Tissues

Balla, Anusha; Auriola, Seppo; Grey, Angus C; Demarais, Nicholas J; Valtari, Annika; Heikkinen, Emma M; Toropainen, Elisa; Urtti, Arto; Vellonen, Kati-Sisko; Ruponen, Marika. 2021. Pharmaceutics. 13: 658

The Effect of Single Nucleotide Variations in the Transmembrane Domain of OATP1B1 on in vitro Functionality

Kiander, Wilma; Vellonen, Kati-Sisko; Malinen, Melina M.; Gynther, Mikko; Hagström, Marja; Bhattacharya, Madhushree; Auriola, Seppo; Koenderink, Jan B.; Kidron, Heidi. 2021. Pharmaceutical research. 38: 1663-1675

Drug Flux Across RPE Cell Models: The Hunt for An Appropriate Outer Blood-Retinal Barrier Model for Use in Early Drug Discovery

Hellinen, Laura; Hongisto, Heidi; Ramsay, Eva; Kaarniranta, Kai; Vellonen, Kati-Sisko; Skottman, Heli; Ruponen, Marika. 2020. Pharmaceutics. 12: 176

Prodrug Approach for Posterior Eye Drug Delivery: Synthesis of Novel Ganciclovir Prodrugs and in Vitro Screening with Cassette Dosing

Heikkinen, Emma M; Ruponen, Marika; Jasper, Lisa-Marie; Leppänen, Jukka; Hellinen, Laura; Urtti, Arto; Auriola, Seppo; Rautio, Jarkko; Vellonen, Kati-Sisko. 2020. Molecular pharmaceutics. 17: 1945-1953

The effect of prolyl oligopeptidase inhibitors on alpha-synuclein aggregation and autophagy cannot be predicted by their inhibitory efficacy

Kilpeläinen, Tommi P; Hellinen, Laura; Vrijdag, Johannes; Yan, Xu; Svarcbahs, Reinis; Vellonen, Kati-Sisko; Lambeir, Anne-Marie; Huttunen, Henri; Urtti, Arto; Wallen, Erik; Myöhänen, Timo. 2020. Biomedicine and pharmacotherapy. 128: 110253

Topical ocular pharmacokinetics and bioavailability for a cocktail of atenolol, timolol and betaxolol in rabbits

Fayyaz, Anam; Ranta, Veli-Pekka; Toropainen, Elisa; Vellonen, Kati-Sisko; Valtari, Annika; Puranen, Jooseppi; Ruponen, Marika; Gardner, Iain; Urtti, Arto; Jamei, Masoud; del Amo, Eva M.. 2020. European journal of pharmaceutical sciences. 155: 105553

Distribution of Small Molecular Weight Drugs into the Porcine Lens: Studies on Imaging Mass Spectrometry, Partition Coefficients, and Implications in Ocular Pharmacokinetics

Heikkinen, EM; Auriola, S; Ranta, VP; Demarais, N; Grey, A; Del Amo, E; Toropainen, E; Vellonen, KS; Urtti, A; Ruponen, M. 2019. Molecular pharmaceutics. 16: 3968-3976

Intravitreal Pharmacokinetics in Mice: SPECT/CT Imaging and Scaling to Rabbits and Humans

Schmitt, Mechthild; Hippeläinen, Eero; Raviña, Manuela; Arango-Gonzalez, Blanca; Antopolsky, Maxim; Vellonen, Kati-Sisko; Airaksinen, Anu J; Urtti, Arto. 2019. Molecular pharmaceutics. 16: 4399-4404

L-Type Amino Acid Transporter 1 (LAT1)-Utilizing Prodrugs Are Carrier-Selective Despite Having Low Affinity for Organic Anion Transporting Polypeptides (OATPs)

Huttunen, Johanna; Gynther, Mikko; Vellonen, KatiSisko; Huttunen, Kristiina M. 2019. International journal of pharmaceutics. 571: 118714

L-Type Amino Acid Transporter 1 (LAT1/Lat1)-Utilizing Prodrugs Can Improve the Delivery of Drugs into Neurons, Astrocytes and Microglia

Huttunen J, Peltokangas S, Gynther M, Natunen T, Hiltunen M, Auriola S, Ruponen M, Vellonen KS, Huttunen KM. 2019. Scientific reports. 9: 12860

Ocular Intracameral Pharmacokinetics for a Cocktail of Timolol, Betaxolol, and Atenolol in Rabbits

Fayyaz, A; Ranta, VP; Toropainen, E; Vellonen, KS; Ricci, GD; Reinisalo, M; Heikkinen, EM; Gardner, I; Urtti, A; Jamei, M; del Amo, EM. 2019. Molecular pharmaceutics. 12: e007045

Role of retinal pigment epithelium permeability in drug transfer between posterior eye segment and systemic blood circulation

Ramsay, E; Hagström, M; Vellonen, KS; Boman, S; Toropainen, E; Del Amo, EM; Kidron, H; Urtti, A; Ruponen, M. 2019. European journal of pharmaceutics and biopharmaceutics. 143: 18-23

Alzheimer's Disease Phenotype or Inflammatory Insult Does Not Alter Function of L-Type Amino Acid Transporter 1 in Mouse Blood-Brain Barrier and Primary Astrocytes

Gynther, Mikko; Puris, Elena; Peltokangas, Soile; Auriola, Seppo; Kanninen, Katja M; Koistinaho, Jari; Huttunen, Kristiina M; Ruponen, Marika; Vellonen, Kati-Sisko. 2018. Pharmaceutical research. 2019; 36: 17

Disease-Induced Alterations in Brain Drug Transporters in Animal Models of Alzheimer's Disease

Vellonen KS, Ihalainen J, Boucau M-C, Gosselet F, Picardat T, Gynther M, Kanninen KM, White AR, Malm T, Koistinaho J, Forsberg MM, Ruponen M. 2017. Pharmaceutical research. 34: 2652-2662

Farmakokinetiikan perusteet

Ranta Veli-Pekka, Honkakoski Paavo, Ruponen Marika, Vellonen Kati-Sisko. 2017. . . Farmasian opiskelijayhdistys Fortis ry

Pharmacokinetic aspects of retinal drug delivery

del Amo Eva M, Rimpelä Anna-Kaisa, Heikkinen Emma, Kari Otto K, Ramsay Eva, Lajunen Tatu, Schmitt Mechthild, Pelkonen Laura, Bhattacharya Madhushree, Richardson Dominique, Subrizi Astrid, Turunen Tiina, Reinisalo Mika, Itkonen Jaakko, Toropainen Elisa, Casteleijn Marco, Kidron Heidi, Antopolsky Maxim, Vellonen Kati-Sisko, Ruponen Marika, et al.. 2017. Progress in retinal and eye research. 57: 134-185

Genetically Modified Caco-2 Cells With Improved Cytochrome P450 Metabolic Capacity

Küblbeck Jenni, Hakkarainen Jenni J, Petsalo Aleksanteri, Vellonen Kati-Sisko, Tolonen Ari, Reponen Petri, Forsberg Markus M, Honkakoski Paavo. 2016. Journal of pharmaceutical sciences. 105: 941-949

Human corneal cell culture models for drug toxicity studies

Rönkkö Seppo, Vellonen Kati-Sisko, Järvinen Kristiina, Toropainen Elisa, Urtti Arto. 2016. Drug delivery and translational research. 6: 660-675

Intracellular PK/PD Relationships of Free and Liposomal Doxorubicin: Quantitative Analyses and PK/PD Modeling

Soininen Suvi K, Vellonen Kati-Sisko, Heikkinen Aki T, Auriola Seppo, Ranta Veli-Pekka, Urtti Arto, Ruponen Marika. 2016. Molecular pharmaceutics. 13: 1358-1365

Cellular and Nuclear Concentrations and Cytotoxicity of Anticancer Drug Doxorubicin and its Liposomal Formulations in Two Cancer Cell Types

Soininen Suvi K, Vellonen Kati-Sisko, Koivisto Heta, Urtti Arto, Ruponen Marika. 2015. Publications of the University of Eastern Finland. Reports and studies in health sciences

Intravitreal clearance and volume of distribution of compounds in rabbits: In silico prediction and pharmacokinetic simulations for drug development

Del Amo Eva M, Vellonen Kati-Sisko, Kidron Heidi, Urtti Arto. 2015. European journal of pharmaceutics and biopharmaceutics. 95: 215-226

Prediction of ocular drug distribution from systemic blood circulation

Vellonen Kati-Sisko, Soini Esa-Matti, del Amo Eva M, Urtti Arto. 2015. Molecular pharmaceutics. 13 (2016): 2906-2911

A critical assessment of in vitro tissue models for ADME and drug delivery

Vellonen Kati-Sisko, Malinen Melina, Mannermaa Eliisa, Subrizi Astrid, Toropainen Elisa, Lou Yan-Ru, Kidron Heidi, Yliperttula Marjo, Urtti Arto. 2014. Journal of controlled release. 190: 94-114

Poor Cellular Internalization of Caelyx® Limits its Toxic Effect Compared with Free Doxorubicin and pH-sensitive Liposomes Encapsulating Doxorubicin

Soininen Suvi K, Koivisto Heta, Vellonen Kati-Sisko, Urtti Arto, Ruponen Marika. 2014. -

Quantitative Analysis of Intracellular Pharmacokinetics of Doxorubicin and its Liposomal Formulations and A Computational Model of the Intracellular PK/PD Relationship

Soininen Suvi K, Välitalo Pyry, Koivisto Heta, Heikkinen Aki, Ranta Veli-Pekka, Vellonen Kati-Sisko, Urtti Arto, Ruponen Marika. 2014. Publications of the University of Eastern Finland. Reports and studies in health sciences

Challenges of using in vitro data for modeling p-glycoprotein efflux in the blood-brain barrier

Sjöstedt Noora, Kortejärvi Hanna, Kidron Heidi, Vellonen Kati-Sisko, Urtti Arto, Yliperttula Marjo. 2013. Pharmaceutical research. 2014:31: 1-19

Prediction of the vitreal half-life of small molecular drug-like compounds

Kidron, Heidi; del Amo, Eva M; Vellonen, Kati-Sisko; Urtti, Arto. 2012. Pharmaceutical research. 29: 3302-3311

Monocarboxylate transport in human corneal epithelium and cell lines

Vellonen Kati-Sisko, Häkli Marika, Merezhinskaya Natalya, Tervo Timo, Honkakoski Paavo, Urtti Arto. 2010. European journal of pharmaceutical sciences. 39: 241-247

Substrates and inhibitors of efflux proteins interfere with the MTT assay in cells and may lead to underestimation of drug toxicity

Vellonen K-S, Honkakoski P, Urtti A. 2004. European journal of pharmaceutical sciences. 23: 181-188

Ocular pharmacokinetic modeling using corneal absorption and desorption rates from in vitro permeation experiments with cultured corneal epithelial cells

Ranta V-P, Laavola M, Toropainen E, Vellonen K-S, Talvitie A, Urtti A. 2003. Pharmaceutical research. 20: 1409-1416

Paracellular and passive transcellular permeability in immortalized human corneal epithelial cell culture model

Toropainen E, Ranta V-P, Vellonen K-S, Palmgrén J, Talvitie A, Laavola M, Suhonen P, Hämäläinen KM, Auriola S, Urtti A. 2003. European journal of pharmaceutical sciences. 20: 99-106

Tarkenna hakuasi

Tutkimusryhmät

Avainsanat

Comprehensive ocular and systemic pharmacokinetics of dexamethasone after subconjunctival and intravenous injections in rabbits

Aldehyde oxidase 1 activity and protein expression in human, rabbit, and pig ocular tissues

Altering distribution profile of palbociclib by its prodrugs

Comparison of barrier properties of outer blood-retinal barrier models - Human stem cell-based models as a novel tool for ocular drug discovery

Functional Characterization of Six SLCO1B1 (OATP1B1) Variants Observed in Finnish Individuals with a Psychotic Disorder

In vitro identification of decreased function phenotype ABCG2 variants

Mass spectrometry in ocular drug research

A Novel Ferroptosis Inhibitor UAMC-3203, a Potential Treatment for Corneal Epithelial Wound

Functional in vitro characterization of SLCO1B1 variants and simulation of the clinical pharmacokinetic impact of impaired OATP1B1 function.

Retraction: Hellinen et al. Drug Flux across RPE Cell Models: The Hunt for an Appropriate Outer Blood–Retinal Barrier Model for Use in Early Drug Discovery. Pharmaceutics 2020, 12, 176

Understanding dexamethasone kinetics in the rabbit tear fluid: Drug release and clearance from solution, suspension and hydrogel formulations

Biopharmaceutics of Topical Ophthalmic Suspensions: Importance of Viscosity and Particle Size in Ocular Absorption of Indomethacin

Ocular pharmacokinetics of atenolol, timolol and betaxolol cocktail: tissue exposures in the rabbit eye

Partitioning and Spatial Distribution of Drugs in Ocular Surface Tissues

The Effect of Single Nucleotide Variations in the Transmembrane Domain of OATP1B1 on in vitro Functionality

Drug Flux Across RPE Cell Models: The Hunt for An Appropriate Outer Blood-Retinal Barrier Model for Use in Early Drug Discovery

Prodrug Approach for Posterior Eye Drug Delivery: Synthesis of Novel Ganciclovir Prodrugs and in Vitro Screening with Cassette Dosing

The effect of prolyl oligopeptidase inhibitors on alpha-synuclein aggregation and autophagy cannot be predicted by their inhibitory efficacy

Topical ocular pharmacokinetics and bioavailability for a cocktail of atenolol, timolol and betaxolol in rabbits

Distribution of Small Molecular Weight Drugs into the Porcine Lens: Studies on Imaging Mass Spectrometry, Partition Coefficients, and Implications in Ocular Pharmacokinetics

Intravitreal Pharmacokinetics in Mice: SPECT/CT Imaging and Scaling to Rabbits and Humans

L-Type Amino Acid Transporter 1 (LAT1)-Utilizing Prodrugs Are Carrier-Selective Despite Having Low Affinity for Organic Anion Transporting Polypeptides (OATPs)

L-Type Amino Acid Transporter 1 (LAT1/Lat1)-Utilizing Prodrugs Can Improve the Delivery of Drugs into Neurons, Astrocytes and Microglia

Ocular Intracameral Pharmacokinetics for a Cocktail of Timolol, Betaxolol, and Atenolol in Rabbits

Role of retinal pigment epithelium permeability in drug transfer between posterior eye segment and systemic blood circulation

Alzheimer's Disease Phenotype or Inflammatory Insult Does Not Alter Function of L-Type Amino Acid Transporter 1 in Mouse Blood-Brain Barrier and Primary Astrocytes

Esterase activity in porcine and albino rabbit ocular tissues

Expression, activity and pharmacokinetic impact of ocular transporters

Iho lääkeaineiden antoreittinä

Keuhkot lääkeaineen antoreittinä

Suun kautta otettujen lääkeaineiden imeytyminen

Disease-Induced Alterations in Brain Drug Transporters in Animal Models of Alzheimer's Disease

Farmakokinetiikan perusteet

Pharmacokinetic aspects of retinal drug delivery

Genetically Modified Caco-2 Cells With Improved Cytochrome P450 Metabolic Capacity

Human corneal cell culture models for drug toxicity studies

Intracellular PK/PD Relationships of Free and Liposomal Doxorubicin: Quantitative Analyses and PK/PD Modeling

Cellular and Nuclear Concentrations and Cytotoxicity of Anticancer Drug Doxorubicin and its Liposomal Formulations in Two Cancer Cell Types

Intravitreal clearance and volume of distribution of compounds in rabbits: In silico prediction and pharmacokinetic simulations for drug development

Prediction of ocular drug distribution from systemic blood circulation

A critical assessment of in vitro tissue models for ADME and drug delivery

Poor Cellular Internalization of Caelyx® Limits its Toxic Effect Compared with Free Doxorubicin and pH-sensitive Liposomes Encapsulating Doxorubicin

Quantitative Analysis of Intracellular Pharmacokinetics of Doxorubicin and its Liposomal Formulations and A Computational Model of the Intracellular PK/PD Relationship

Challenges of using in vitro data for modeling p-glycoprotein efflux in the blood-brain barrier

Prediction of the vitreal half-life of small molecular drug-like compounds

Monocarboxylate transport in human corneal epithelium and cell lines

Substrates and inhibitors of efflux proteins interfere with the MTT assay in cells and may lead to underestimation of drug toxicity

Ocular pharmacokinetic modeling using corneal absorption and desorption rates from in vitro permeation experiments with cultured corneal epithelial cells

Paracellular and passive transcellular permeability in immortalized human corneal epithelial cell culture model