KATI-SISKO VELLONEN

Yhteystiedot

Avainsanat

Tutkimusryhmät - UEF

• 
  Silmälääketutkimusryhmä

Julkaisut

• Balla, Anusha; Auriola, Seppo; Grey, Angus C; Demarais, Nicholas J; Valtari, Annika; Heikkinen, Emma M; Toropainen, Elisa; Urtti, Arto; Vellonen, Kati-Sisko; Ruponen, Marika. 2021. Partitioning and Spatial Distribution of Drugs in Ocular Surface Tissues Pharmaceutics 13 5: 658. 2021
• Kiander, Wilma; Vellonen, Kati-Sisko; Malinen, Melina M.; Gynther, Mikko; Hagström, Marja; Bhattacharya, Madhushree; Auriola, Seppo; Koenderink, Jan B.; Kidron, Heidi. 2021. The Effect of Single Nucleotide Variations in the Transmembrane Domain of OATP1B1 on in vitro Functionality Pharmaceutical research 38 10: 1663-1675. 2021
• Toropainen, Elisa; Fraser-Miller, Sara J; Novakovic, Dunja; Del Amo, Eva M; Vellonen, Kati-Sisko; Ruponen, Marika; Viitala, Tapani; Korhonen, Ossi; Auriola, Seppo; Hellinen, Laura; Reinisalo, Mika; Tengvall, Unni; Choi, Stephanie; Absar, Mohammad; Strachan, Clare; Urtti, Arto. 2021. Biopharmaceutics of Topical Ophthalmic Suspensions: Importance of Viscosity and Particle Size in Ocular Absorption of Indomethacin Pharmaceutics 13 4: 452. 2021
• Fayyaz, Anam; Vellonen, Kati-Sisko; Ranta, Veli-Pekka; Toropainen, Elisa; Reinisalo, Mika; Valtari, Annika; Puranen, Jooseppi; D'Amico Ricci, Giuseppe; Heikkinen, Emma M.; Gardner, Iain; Ruponen, Marika; Urtti, Arto; Jamei, Masoud; del Amo, Eva M. 2021. Ocular pharmacokinetics of atenolol, timolol and betaxolol cocktail: tissue exposures in the rabbit eye European journal of pharmaceutics and biopharmaceutics 166: 155-162. 2021
• Fayyaz, Anam; Ranta, Veli-Pekka; Toropainen, Elisa; Vellonen, Kati-Sisko; Valtari, Annika; Puranen, Jooseppi; Ruponen, Marika; Gardner, Iain; Urtti, Arto; Jamei, Masoud; del Amo, Eva M.. 2020. Topical ocular pharmacokinetics and bioavailability for a cocktail of atenolol, timolol and betaxolol in rabbits European journal of pharmaceutical sciences 155: 105553. 2020
• Heikkinen, Emma M; Ruponen, Marika; Jasper, Lisa-Marie; Leppänen, Jukka; Hellinen, Laura; Urtti, Arto; Auriola, Seppo; Rautio, Jarkko; Vellonen, Kati-Sisko. 2020. Prodrug Approach for Posterior Eye Drug Delivery: Synthesis of Novel Ganciclovir Prodrugs and in Vitro Screening with Cassette Dosing Molecular pharmaceutics 17 6: 1945-1953. 2020
• Hellinen, Laura; Hongisto, Heidi; Ramsay, Eva; Kaarniranta, Kai; Vellonen, Kati-Sisko; Skottman, Heli; Ruponen, Marika. 2020. Drug Flux Across RPE Cell Models: The Hunt for An Appropriate Outer Blood-Retinal Barrier Model for Use in Early Drug Discovery Pharmaceutics 12 2: 176. 2020
• Kilpeläinen, Tommi P; Hellinen, Laura; Vrijdag, Johannes; Yan, Xu; Svarcbahs, Reinis; Vellonen, Kati-Sisko; Lambeir, Anne-Marie; Huttunen, Henri; Urtti, Arto; Wallen, Erik; Myöhänen, Timo. 2020. The effect of prolyl oligopeptidase inhibitors on alpha-synuclein aggregation and autophagy cannot be predicted by their inhibitory efficacy Biomedicine and pharmacotherapy 128: 110253. 2020
• Fayyaz, A; Ranta, VP; Toropainen, E; Vellonen, KS; Ricci, GD; Reinisalo, M; Heikkinen, EM; Gardner, I; Urtti, A; Jamei, M; del Amo, EM. 2019. Ocular Intracameral Pharmacokinetics for a Cocktail of Timolol, Betaxolol, and Atenolol in Rabbits Molecular pharmaceutics 12 4: e007045. 2019
• Heikkinen, EM; Auriola, S; Ranta, VP; Demarais, N; Grey, A; Del Amo, E; Toropainen, E; Vellonen, KS; Urtti, A; Ruponen, M. 2019. Distribution of Small Molecular Weight Drugs into the Porcine Lens: Studies on Imaging Mass Spectrometry, Partition Coefficients, and Implications in Ocular Pharmacokinetics Molecular pharmaceutics 16 9: 3968-3976. 2019
• Huttunen J, Peltokangas S, Gynther M, Natunen T, Hiltunen M, Auriola S, Ruponen M, Vellonen KS, Huttunen KM. 2019. L-Type Amino Acid Transporter 1 (LAT1/Lat1)-Utilizing Prodrugs Can Improve the Delivery of Drugs into Neurons, Astrocytes and Microglia Scientific reports 9: 12860. 2019
• Huttunen, Johanna; Gynther, Mikko; Vellonen, KatiSisko; Huttunen, Kristiina M. 2019. L-Type Amino Acid Transporter 1 (LAT1)-Utilizing Prodrugs Are Carrier-Selective Despite Having Low Affinity for Organic Anion Transporting Polypeptides (OATPs) International journal of pharmaceutics 571: 118714. 2019
• Ramsay, E; Hagström, M; Vellonen, KS; Boman, S; Toropainen, E; Del Amo, EM; Kidron, H; Urtti, A; Ruponen, M. 2019. Role of retinal pigment epithelium permeability in drug transfer between posterior eye segment and systemic blood circulation European journal of pharmaceutics and biopharmaceutics 143: 18-23. 2019
• Schmitt, Mechthild; Hippeläinen, Eero; Raviña, Manuela; Arango-Gonzalez, Blanca; Antopolsky, Maxim; Vellonen, Kati-Sisko; Airaksinen, Anu J; Urtti, Arto. 2019. Intravitreal Pharmacokinetics in Mice: SPECT/CT Imaging and Scaling to Rabbits and Humans Molecular pharmaceutics 16 10: 4399-4404. 2019
• Suun kautta otettujen lääkeaineiden imeytyminen. Urtti, Arto; Ruponen, Marika; Pajula, Katja; Yliperttula, Marjo; Honkakoski, Paavo; Ranta, Veli-Pekka; Kidron, Heidi; Vellonen, Kati-Sisko / Biofarmasian perusteet. 2018. 2018
• Vellonen, Kati-Sisko; Hellinen, Laura; Mannermaa, Eliisa; Ruponen, Marika; Urtti, Arto; Kidron, Heidi. 2018. Expression, activity and pharmacokinetic impact of ocular transporters ADVANCED DRUG DELIVERY REVIEWS 126: 3-22. 2018
• Heikkinen, Emma M; del Amo, Eva M; Ranta, Veli-Pekka; Urtti, Arto; Vellonen, Kati-Sisko; Ruponen, Marika. 2018. Esterase activity in porcine and albino rabbit ocular tissues European journal of pharmaceutical sciences 123: 106-110. 2018
• Gynther, Mikko; Puris, Elena; Peltokangas, Soile; Auriola, Seppo; Kanninen, Katja M; Koistinaho, Jari; Huttunen, Kristiina M; Ruponen, Marika; Vellonen, Kati-Sisko. 2018. Alzheimer's Disease Phenotype or Inflammatory Insult Does Not Alter Function of L-Type Amino Acid Transporter 1 in Mouse Blood-Brain Barrier and Primary Astrocytes PHARMACEUTICAL RESEARCH 2019; 36: 17. 2018
• del Amo Eva M, Rimpelä Anna-Kaisa, Heikkinen Emma, Kari Otto K, Ramsay Eva, Lajunen Tatu, Schmitt Mechthild, Pelkonen Laura, Bhattacharya Madhushree, Richardson Dominique, Subrizi Astrid, Turunen Tiina, Reinisalo Mika, Itkonen Jaakko, Toropainen Elisa, Casteleijn Marco, Kidron Heidi, Antopolsky Maxim, Vellonen Kati-Sisko, Ruponen Marika, et al.. 2017. Pharmacokinetic aspects of retinal drug delivery PROGRESS IN RETINAL AND EYE RESEARCH 57: 134-185. 2017
• Ranta Veli-Pekka, Honkakoski Paavo, Ruponen Marika, Vellonen Kati-Sisko (toim.). 2017. Farmakokinetiikan perusteet. Farmasian opiskelijayhdistys Fortis ry. 2017
• Vellonen KS, Ihalainen J, Boucau M-C, Gosselet F, Picardat T, Gynther M, Kanninen KM, White AR, Malm T, Koistinaho J, Forsberg MM, Ruponen M. 2017. Disease-Induced Alterations in Brain Drug Transporters in Animal Models of Alzheimer's Disease. PHARMACEUTICAL RESEARCH 34 12: 2652-2662. 2017
• Küblbeck Jenni, Hakkarainen Jenni J, Petsalo Aleksanteri, Vellonen Kati-Sisko, Tolonen Ari, Reponen Petri, Forsberg Markus M, Honkakoski Paavo. 2016. Genetically Modified Caco-2 Cells With Improved Cytochrome P450 Metabolic Capacity. JOURNAL OF PHARMACEUTICAL SCIENCES 105 2: 941-949. 2016
• Rönkkö Seppo, Vellonen Kati-Sisko, Järvinen Kristiina, Toropainen Elisa, Urtti Arto. 2016. Human corneal cell culture models for drug toxicity studies. Drug Delivery and Translational Research 6 6: 660-675. 2016
• Soininen Suvi K, Vellonen Kati-Sisko, Heikkinen Aki T, Auriola Seppo, Ranta Veli-Pekka, Urtti Arto, Ruponen Marika. 2016. Intracellular PK/PD Relationships of Free and Liposomal Doxorubicin: Quantitative Analyses and PK/PD Modeling. Molecular Pharmaceutics 13 4: 1358-1365. 2016
• Vellonen Kati-Sisko, Soini Esa-Matti, del Amo Eva M, Urtti Arto. 2015. Prediction of ocular drug distribution from systemic blood circulation Molecular pharmaceutics 13 (2016) 9: 2906-2911. 2015
• Del Amo Eva M, Vellonen Kati-Sisko, Kidron Heidi, Urtti Arto. 2015. Intravitreal clearance and volume of distribution of compounds in rabbits: In silico prediction and pharmacokinetic simulations for drug development. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 95: 215-226. 2015
• Vellonen Kati-Sisko, Malinen Melina, Mannermaa Eliisa, Subrizi Astrid, Toropainen Elisa, Lou Yan-Ru, Kidron Heidi, Yliperttula Marjo, Urtti Arto. 2014. A critical assessment of in vitro tissue models for ADME and drug delivery. JOURNAL OF CONTROLLED RELEASE 190: 94-114. 2014
• Sjöstedt Noora, Kortejärvi Hanna, Kidron Heidi, Vellonen Kati-Sisko, Urtti Arto, Yliperttula Marjo. 2013. Challenges of using in vitro data for modeling p-glycoprotein efflux in the blood-brain barrier. PHARMACEUTICAL RESEARCH 2014:31: 1-19. 2013
• Kidron, Heidi; del Amo, Eva M; Vellonen, Kati-Sisko; Urtti, Arto. 2012. Prediction of the vitreal half-life of small molecular drug-like compounds Pharmaceutical research 29: 3302-3311. 2012
• Vellonen Kati-Sisko, Häkli Marika, Merezhinskaya Natalya, Tervo Timo, Honkakoski Paavo, Urtti Arto. 2010. Monocarboxylate transport in human corneal epithelium and cell lines. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 39: 241-247. 2010
• Vellonen K-S, Honkakoski P, Urtti A. 2004. Substrates and inhibitors of efflux proteins interfere with the MTT assay in cells and may lead to underestimation of drug toxicity. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 23: 181-188. 2004
• Ranta V-P, Laavola M, Toropainen E, Vellonen K-S, Talvitie A, Urtti A. 2003. Ocular pharmacokinetic modeling using corneal absorption and desorption rates from in vitro permeation experiments with cultured corneal epithelial cells. PHARMACEUTICAL RESEARCH 20 9: 1409-1416. 2003
• Toropainen E, Ranta V-P, Vellonen K-S, Palmgrén J, Talvitie A, Laavola M, Suhonen P, Hämäläinen KM, Auriola S, Urtti A. 2003. Paracellular and passive transcellular permeability in immortalized human corneal epithelial cell culture model. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 20: 99-106. 2003