Kati Hanhineva
Tutkimusjohtaja
Kansanterveystieteen ja kliinisen ravitsemustieteen yksikkö, Lääketieteen laitos, Terveystieteiden tiedekunta
kati.hanhineva@uef.fi | 040 355 2364
Tutkimusryhmät
Julkaisut
125/125 kappaletta-
Identification of metabolites produced by six gut commensal Bacteroidales strains using non-targeted LC-MS/MS metabolite profiling
Fernandez-Cantos, Maria Victoria; Babu, Ambrin Farizah; Hanhineva, Kati; Kuipers, Oscar P. 2024. Microbiological research. 283: -
Metabolic changes in response to varying whole-grain wheat and rye intake
Koistinen, Ville M; Haldar, Sumanto; Tuomainen, Marjo; Lehtonen, Marko; Klåvus, Anton; Draper, John; Lloyd, Amanda; Beckmann, Manfred; Bal, Wendy; Ross, Alastair B; Brandt, Kirsten; Fawcett, Lee; Seal, Chris; Hanhineva, Kati. 2024. npj science of food. 8: . 8 -
Associations of altered hepatic gene expression in American lifestyle-induced obesity syndrome diet-fed mice with metabolic changes during NAFLD development and progression
Iannone, V; Lok, J; Babu, AF; Gómez-Gallego, C; Willman, RM; Koistinen, VM; Klåvus, A; Kettunen, MI; Kårlund, A; Schwab, U; Hanhineva, K; Kolehmainen, M; Nezami, H El. 2023. Journal of nutritional biochemistry. 115: -
Changes in liver metabolic pathways demonstrate efficacy of the combined dietary and microbial therapeutic intervention in MASLD mouse model
Iannone, Valeria; Babu, Ambrin Farizah; Lok, Johnson; Gómez-Gallego, Carlos; D’Auria, Giuseppe; Vazquez-Uribe, Ruben; Vaaben, Troels Holger; Bongers, Mareike; Mikkonen, Santtu; Vaittinen, Maija; Tikkanen, Ida; Kettunen, Mikko; Klåvus, Anton; Sehgal, Ratika; Kaminska, Dorota; Pihlajamaki, Jussi; Hanhineva, Kati; El-Nezami, Hani; Alexander Sommer, Morten Otto; Kolehmainen, Marjukka. 2023. Molecular metabolism. 78: -
Cold-stimulated brown adipose tissue activation is related to changes in serum metabolites relevant to NAD+ metabolism in humans
U-Din, Mueez; de Mello, Vanessa D; Tuomainen, Marjo; Raiko, Juho; Niemi, Tarja; Fromme, Tobias; Klåvus, Anton; Gautier, Nadine; Haimilahti, Kimmo; Lehtonen, Marko; Kristiansen, Karsten; Newman, John W; Pietiläinen, Kirsi H; Pihlajamäki, Jussi; Amri, Ez-Zoubir; Klingenspor, Martin; Nuutila, Pirjo; Pirinen, Eija; Hanhineva, Kati; Virtanen, Kirsi A. 2023. Cell reports. 42: -
Impacts of maternal microbiota and microbial metabolites on fetal intestine, brain, and placenta
Husso, Aleksi; Pessa-Morikawa, Tiina; Koistinen, Ville Mikael; Kärkkäinen, Olli; Kwon, Hyuk Nam; Lahti, Leo; Iivanainen, Antti; Hanhineva, Kati; Niku, Mikael. 2023. Bmc biology. 21: . 207 -
Metabolic profiles reflect weight loss maintenance and the composition of diet after very-low-energy diet
Näätänen, Mari; Kårlund, Anna; Mikkonen, Santtu; Klåvus, Anton; Savolainen, Otto; Lehtonen, Marko; Karhunen, Leila; Hanhineva, Kati; Kolehmainen, Marjukka. 2023. Clinical nutrition. 42: 1126-1141 -
Nutritional metabolomics: Recent developments and future needs
Kortesniemi, Maaria; Noerman, Stefania; Kårlund, Anna; Raita, Jasmin; Meuronen, Topi; Koistinen, Ville; Landberg, Rikard; Hanhineva, Kati. 2023. Current opinion in chemical biology. 77: -
Personoitu ravitsemus – lähiajan arkipäivää vai utopiaa?
Jääskeläinen, Tiina; Hanhineva, Kati; Pajari, Anne-Maria. 2023. Duodecim. 139: 1459-1461 -
Towards a Rosetta stone for metabolomics: recommendations to overcome inconsistent metabolite nomenclature
Koistinen, Ville; Kärkkäinen, Olli; Keski-Rahkonen, Pekka; Tsugawa, Hiroshi; Scalbert, Augustin; Arita, Masanori; Wishart, David; Hanhineva, Kati. 2023. Nature metabolism. 5: 351-354 -
An inverse association between plasma benzoxazinoid metabolites and PSA after rye intake in men with prostate cancer revealed with a new method
Nordin, Elise; Steffensen, Stine K.; Laursen, Bente B.; Andersson, Sven-Olof; Johansson, Jan-Erik; Åman, Per; Hallmans, Göran; Borre, Michael; Stærk, Dan; Hanhineva, Kati; Fomsgaard, Inge S.; Landberg, Rikard. 2022. Scientific reports. 12: . 5260 -
Associations of PFAS-related plasma metabolites with cholesterol and triglyceride concentrations
Schillemans, T; Bergdahl, IA; Hanhineva, K; Shi, L; Donat-Vargas, C; Koponen, J; Kiviranta, H; Landberg, R; Åkesson, A; Brunius, C. 2022. Environmental research. 216: -
Diet- and microbiota-related metabolite, 5-aminovaleric acid betaine (5-AVAB), in health and disease
Haikonen, Retu; Kärkkäinen, Olli; Koistinen, Ville; Hanhineva, Kati. 2022. Trends in endocrinology and metabolism. 33: 463-480 -
Effects of exercise on NAFLD using non-targeted metabolomics in adipose tissue, plasma, urine, and stool
Babu, Ambrin Farizah; Csader, Susanne; Männistö, Ville; Tauriainen, Milla-Maria; Pentikäinen, Heikki; Savonen, Kai; Klåvus, Anton; Koistinen, Ville; Hanhineva, Kati; Schwab, Ursula. 2022. Scientific reports. 12: -
Identification and Distribution of Sterols, Bile Acids, and Acylcarnitines by LC–MS/MS in Humans, Mice, and Pigs—A Qualitative Analysis
Babu, Ambrin Farizah; Koistinen, Ville Mikael; Turunen, Soile; Solano-Aguilar, Gloria; Urban, Joseph F.; Zarei, Iman; Hanhineva, Kati. 2022. Metabolites. 12: -
LongITools: Dynamic longitudinal exposome trajectories in cardiovascular and metabolic noncommunicable diseases
Ronkainen, Justiina; Nedelec, Rozenn; Atehortua, Angelica; Balkhiyarova, Zhanna; Cascarano, Anna; Ngoc Dang, Vien; Elhakeem, Ahmed; van Enckevort, Esther; Goncalves Soares, Ana; Haakma, Sido; Halonen, Miia; Heil, Katharina F.; Heiskala, Anni; Hyde, Eleanor; Jacquemin, Bénédicte; Keikkala, Elina; Kerckhoffs, Jules; Klåvus, Anton; Kopinska, Joanna A.; Lepeule, Johanna; Marazzi, Francesca; Motoc, Irina; Näätänen, Mari; Ribbenstedt, Anton; Rundblad, Amanda; Savolainen, Otto; Simonetti, Valentina; de. 2022. Environmental epidemiology. 6: -
Maternal microbiota-derived metabolic profile in fetal murine intestine, brain and placenta
Pessa-Morikawa, Tiina; Husso, Aleksi; Kärkkäinen, Olli; Koistinen, Ville; Hanhineva, Kati; Iivanainen, Antti; Niku, Mikael. 2022. Bmc microbiology. 22: . 46 -
Metabolite Pattern Derived from Lactiplantibacillus plantarum — Fermented Rye Foods and In Vitro Gut Fermentation Synergistically Inhibits Bacterial Growth
Koistinen, Ville M.; Hedberg, Maria; Shi, Lin; Johansson, Anders; Savolainen, Otto; Lehtonen, Marko; Aura, Anna‐Marja; Hanhineva, Kati; Landberg, Rikard. 2022. Molecular nutrition and food research. 66: -
Microbiota-derived metabolites as drivers of gut–brain communication
Ahmed, Hany; Leyrolle, Quentin; Koistinen, Ville; Kärkkäinen, Olli; Layé, Sophie; Delzenne, Nathalie; Hanhineva, Kati. 2022. Gut microbes. 14: -
No association in maternal serum levels of TMAO and its precursors in pre-eclampsia and in non-complicated pregnancies
Jääskeläinen, Tiina; Kärkkäinen, Olli; Heinonen, Seppo; Hanhineva, Kati; Laivuori, Hannele. 2022. Pregnancy hypertension. 28: 74-80 -
Risk assessment with gut microbiome and metabolite markers in NAFLD development
Leung, Howell; Long, Xiaoxue; Ni, Yueqiong; Qian, Lingling; Nychas, Emmanouil; Siliceo, Sara Leal; Pohl, Dennis; Hanhineva, Kati; Liu, Yan; Xu, Aimin; Nielsen, Henrik B.; Belda, Eugeni; Clément, Karine; Loomba, Rohit; Li, Huating; Jia, Weiping; Panagiotou, Gianni. 2022. Science translational medicine. 14: . eabk0855 -
Serum metabolites associated with wholegrain consumption using nontargeted metabolic profiling: a discovery and reproducibility study
Noerman, Stefania; Virtanen, Jyrki K.; Lehtonen, Marko; Brunius, Carl; Hanhineva, Kati. 2022. European journal of nutrition. 2023; 62: 713-726 -
Tissue-wide metabolomics reveals wide impact of gut microbiota on mice metabolite composition
Zarei, Iman; Koistinen, Ville M.; Kokla, Marietta; Klåvus, Anton; Babu, Ambrin Farizah; Lehtonen, Marko; Auriola, Seppo; Hanhineva, Kati. 2022. Scientific reports. 12: . 15018 -
A non-targeted LC-MS metabolic profiling of pregnancy: longitudinal evidence from healthy and pre-eclamptic pregnancies
Jääskeläinen, Tiina; Kärkkäinen, Olli; Jokkala, Jenna; Klåvus, Anton; Heinonen, Seppo; Auriola, Seppo; Lehtonen, Marko; The FINNPEC Core Investigator Group; Hanhineva, Kati; Laivuori, Hannele. 2021. Metabolomics. 17: 20 -
Associations of the serum metabolite profile with a healthy Nordic diet and risk of coronary artery disease
Noerman, Stefania; Kokla, Marietta; Koistinen, Ville M; Lehtonen, Marko; Tuomainen, Tomi-Pekka; Brunius, Carl; Virtanen, Jyrki K; Hanhineva, Kati. 2021. Clinical nutrition. 40: 3250-3262 -
Changes in the metabolic profile of human male postmortem frontal cortex and cerebrospinal fluid samples associated with heavy alcohol use
Kärkkäinen, Olli; Kokla, Marietta; Lehtonen, Marko; Auriola, Seppo; Martiskainen, Mika; Tiihonen, Jari; Karhunen, Pekka J.; Hanhineva, Kati; Kok, Eloise. 2021. Addiction biology. 26: e13035 -
Data sharing in PredRet for accurate prediction of retention time: Application to plant food bioactive compounds
Low, Dorrain Yanwen; Micheau, Pierre; Koistinen, Ville Mikael; Hanhineva, Kati; Abrankó, László; Rodriguez-Mateos, Ana; da Silva, Andreia Bento; van Poucke, Christof; Almeida, Conceição; Andres-Lacueva, Cristina; Rai, Dilip K.; Capanoglu, Esra; Tomás Barberán, Francisco A.; Mattivi, Fulvio; Schmidt, Gesine; Gürdeniz, Gözde; Valentová, Katerina; Bresciani, Letizia; Petrásková, Lucie; Dragsted, Lars Ove et al.. 2021. Food chemistry. 357: 129757 -
Defining the Scope of Exposome Studies and Research Needs from a Multidisciplinary Perspective
Zhang, Pei; Carlsten, Christopher; Chaleckis, Romanas; Hanhineva, Kati; Huang, Mengna; Isobe, Tomohiko; Koistinen, Ville M.; Meister, Isabel; Papazian, Stefano; Sdougkou, Kalliroi; Xie, Hongyu; Martin, Jonathan W.; Rappaport, Stephen M.; Tsugawa, Hiroshi; Walker, Douglas I.; Woodruff, Tracey J.; Wright, Robert O.; Wheelock, Craig E.. 2021. Environmental science & technology letters. 8: 839-852 -
FADS1 rs174550 genotype and high linoleic acid diet modify plasma PUFA phospholipids in a dietary intervention study
Meuronen, Topi; Lankinen, Maria A.; Kärkkäinen, Olli; Laakso, Markku; Pihlajamäki, Jussi; Hanhineva, Kati; Schwab, Ursula. 2021. European journal of nutrition. 2022; 61: 1109-1120 -
Grains - a major source of sustainable protein for health
Poutanen, Kaisa S; Kårlund, Anna O; Gómez-Gallego, Carlos; Johansson, Daniel P; Scheers, Nathalie M; Marklinder, Ingela M; Eriksen, Anne K; Silventoinen, Pia C; Nordlund, Emilia; Sozer, Nesli; Hanhineva, Kati J; Kolehmainen, Marjukka; Landberg, Rikard. 2021. Nutrition reviews. [Epub ahead of print 6 Nov 2021]: 1 - 16 -
Indole-3-Propionic Acid, a Gut-Derived Tryptophan Metabolite, Associates with Hepatic Fibrosis
Sehgal, Ratika Ilha, Mariana Vaittinen, Maija Kaminska, Dorota Männistö, Ville Kärjä, Vesa Tuomainen, Marjo Hanhineva, Kati Romeo, Stefano Pajukanta, Päivi Pihlajamäki, Jussi de Mello, Vanessa D.. 2021. Nutrients. 13: 3509 -
Low-Dose Doxycycline Treatment Normalizes Levels of Some Salivary Metabolites Associated with Oral Microbiota in Patients with Primary Sjögren's Syndrome
Herrala, Maria; Turunen, Soile; Hanhineva, Kati; Lehtonen, Marko; Mikkonen, Jopi J. W.; Seitsalo, Hubertus; Lappalainen, Reijo; Tjäderhane, Leo; Niemelä, Raija K.; Salo, Tuula; Myllymaa, Sami; Kullaa, Arja M.; Kärkkäinen, Olli. 2021. Metabolites. 11: 595 -
Microbiota and Metabolite Profiling as Markers of Mood Disorders: A Cross-Sectional Study in Obese Patients
Leyrolle, Quentin; Cserjesi, Renata; Demeure, Romane; Neyrinck, Audrey M.; Amadieu, Camille; Rodriguez, Julie; Kärkkäinen, Olli; Hanhineva, Kati; Paquot, Nicolas; Cnop, Miriam; Cani, Patrice D.; Thissen, Jean-Paul; Bindels, Laure B.; Klein, Olivier; Luminet, Olivier; Delzenne, Nathalie M.. 2021. Nutrients. 2022; 14: 147 -
Positive Effects of Exercise Intervention without Weight Loss and Dietary Changes in NAFLD-Related Clinical Parameters: A Systematic Review and Meta-Analysis
Babu, Ambrin Farizah; Csader, Susanne; Lok, Johnson; Gómez-Gallego, Carlos; Hanhineva, Kati; El-Nezami, Hani; Schwab, Ursula. 2021. Nutrients. 13: 3135 -
Putative metabolites involved in the beneficial effects of wholegrain cereal: Nontargeted metabolite profiling approach
Vitale, Marilena; Hanhineva, Kati; Koistinen, Ville; Auriola, Seppo; Paananen, Jussi; Costabile, Giuseppina; Della Pepa, Giuseppe; Rivellese, Angela A.; Riccardi, Gabriele; Giacco, Rosalba. 2021. Nutrition metabolism and cardiovascular diseases. 31: 1156-1165 -
Specific gut microbial, biological, and psychiatric profiling related to binge eating disorders: A cross-sectional study in obese patients
Leyrolle, Quentin; Cserjesi, Renata; Mulders, Maria DGH; Zamariola, Giorgia; Hiel, Sophie; Gianfrancesco, Marco A; Rodriguez, Julie; Portheault, Daphnée; Amadieu, Camille; Leclercq, Sophie; Bindels, Laure B; Neyrinck, Audrey M; Cani, Patrice D; Karkkainen, Olli; Haninheva, Kati; Lanthier, Nicolas; Trefois, Pierre; Paquot, Nicolas; Cnop, Miriam; Luminet, Olivier et al.. 2021. Clinical nutrition. 40: 2034-2044 -
Terpenoid and lipid profiles vary in different Phytophthora cactorum - strawberry interactions
Toljamo, Anna; Koistinen, Ville; Hanhineva, Kati; Kärenlampi, Sirpa; Kokko, Harri. 2021. Phytochemistry. 189: 112820 -
"notame": Workflow for Non-Targeted LC-MS Metabolic Profiling
Klåvus, Anton; Kokla, Marietta; Noerman, Stefania; Koistinen, Ville M; Tuomainen, Marjo; Zarei, Iman; Meuronen, Topi; Häkkinen, Merja R; Rummukainen, Soile; Farizah Babu, Ambrin; Sallinen, Taisa; Kärkkäinen, Olli; Paananen, Jussi; Broadhurst, David; Brunius, Carl; Hanhineva, Kati. 2020. Metabolites. 10: 135 -
Cancer Alters the Metabolic Fingerprint of Extracellular Vesicles
Palviainen, Mari; Laukkanen, Kirsi; Tavukcuoglu, Zeynep; Velagapudi, Vidya; Kärkkäinen, Olli; Hanhineva, Kati; Auriola, Seppo; Ranki, Annamari; Siljander, Pia. 2020. Cancers. 12: 3292 -
Metabolome of canine and human saliva: a non-targeted metabolomics study
Turunen, Soile; Puurunen, Jenni; Auriola, Seppo; Kullaa, Arja M; Kärkkäinen, Olli; Lohi, Hannes; Hanhineva, Kati. 2020. Metabolomics. 16: 90 -
Metabolomics analysis of plasma and adipose tissue samples from mice orally administered with polydextrose and correlations with cecal microbiota
Saarinen, Markku Tapani; Kärkkäinen, Olli; Hanhineva, Kati; Tiihonen, Kirsti; Hibberd, Ashley; Mäkelä, Kari Antero; Raza, Ghulam Shere; Herzig, Karl-Heinz; Anglenius, Heli. 2020. Scientific reports. 10: 21577 -
Plasma lipid profile associates with the improvement of psychological well-being in individuals with perceived stress symptoms
Noerman, S; Klåvus, A; Järvelä-Reijonen, E; Karhunen, L; Auriola, S; Korpela, R; Lappalainen, R; Kujala, UM; Puttonen, S; Kolehmainen, M; Hanhineva, K. 2020. Scientific reports. 10: 2143 -
Plasma metabolites associated with exposure to perfluoroalkyl substances and risk of type 2 diabetes - A nested case-control study
Schillemans, Tessa; Shi, Lin; Donat-Vargas, Carolina; Hanhineva, Kati; Tornevi, Andreas; Johansson, Ingegerd; Koponen, Jani; Kiviranta, Hannu; Rolandsson, Olov; Bergdahl, Ingvar A; Landberg, Rikard; Åkesson, Agneta; Brunius, Carl. 2020. Environment international. 146: 106180 -
Profiling of Endogenous and Gut Microbial Metabolites to Indicate Metabotype-Specific Dietary Responses: A Systematic Review
Noerman, Stefania; Kolehmainen, Marjukka; Hanhineva, Kati. 2020. Advances in nutrition. 11: 1237-1254 -
Quantifying the human diet in the crosstalk between nutrition and health by multi-targeted metabolomics of food and microbiota-derived metabolites
González-Domínguez, Raúl; Jáuregui, Olga; Mena, Pedro; Hanhineva, Kati; Tinahones, Francisco José; Angelino, Donato; Andrés-Lacueva, Cristina. 2020. International journal of obesity. 44: 2372-2381 -
Serum aromatic and branched-chain amino acids associated with NASH demonstrate divergent associations with serum lipids
de Mello, Vanessa D; Sehgal, Ratika; Männistö, Ville; Klåvus, Anton; Nilsson, Emma; Perfilyev, Alexander; Kaminska, Dorota; Miao, Zong; Pajukanta, Päivi; Ling, Charlotte; Hanhineva, Kati; Pihlajamäki, Jussi. 2020. Liver international. 2021; 41: 754-763 -
Side-stream products of malting: a neglected source of phytochemicals
Koistinen, Ville M; Tuomainen, Marjo; Lehtinen, Pekka; Peltola, Petri; Auriola, Seppo; Jonsson, Karin; Hanhineva, Kati. 2020. npj science of food. 4: 21 -
A MYB Triad Controls Primary and Phenylpropanoid Metabolites for Pollen Coat Patterning
Battat, Maor; Eitan, Asa; Rogachev, Ilana; Hanhineva, Kati; Fernie, Alisdair; Tohge, Takayuki; Beekwilder, Jules; Aharoni, Asaph. 2019. Plant physiology. 180: 87-108 -
Biomarkers of a Healthy Nordic Diet-From Dietary Exposure Biomarkers to Microbiota Signatures in the Metabolome
Landberg, R; Hanhineva, K. 2019. Nutrients. 12: 27 -
Biomarkers of cereal food intake
Landberg, R; Hanhineva, K; Tuohy, K; Garcia-Aloy, M; Biskup, I; Llorach, R; Yin, X; Brennan, L; Kolehmainen, M. 2019. Genes and nutrition. 14: 28 -
Biomarkers of meat and seafood intake: an extensive literature review
Cuparencu, Catalina; Praticó, Giulia; Hemeryck, Lieselot Y; Sri Harsha, Pedapati SC; Noerman, Stefania; Rombouts, Caroline; Xi, Muyao; Vanhaecke, Lynn; Hanhineva, Kati; Brennan, Lorraine; Dragsted, Lars O. 2019. Genes and nutrition. 14: 35 -
Contribution of gut microbiota to metabolism of dietary glycine betaine in mice and in vitro colonic fermentation
Koistinen, VM; Kärkkäinen, O; Borewicz, K; Zarei, I; Jokkala, J; Micard, V; Rosa-Sibakov, N; Auriola, S; Aura, AM; Smidt, H; Hanhineva, K. 2019. Microbiome. 7: 103 -
Decreased plasma serotonin and other metabolite changes in healthy adults after consumption of wholegrain rye: an untargeted metabolomics study
Keski-Rahkonen, Pekka; Kolehmainen, Marjukka; Lappi, Jenni; Micard, Valerie; Jokkala, Jenna; Rosa-Sibakov, Natalia; Pihlajamäki, Jussi; Kirjavainen, Pirkka V; Mykkänen, Hannu; Poutanen, Kaisa; Gunter, Marc J; Scalbert, Augustin; Hanhineva, Kati. 2019. American journal of clinical nutrition. 109: 1630-1639 -
Factors Explaining Inter-Personal Variation in Plasma Enterolactone Concentrations in Humans
Hålldin, E; Eriksen, AK; Brunius, C; da Silva, AB; Bronze, M; Hanhineva, K; Aura, AM; Landberg, R. 2019. Molecular nutrition and food research. 63: 1801159 -
Factors affecting intake, metabolism and health benefits of phenolic acids: do we understand individual variability?
Bento-Silva, A; Koistinen, VM; Mena, P; Bronze, MR; Hanhineva, K; Sahlstrøm, S; Kitryte, V; Moco, S; Aura, AM. 2019. European journal of nutrition. [First Online 21 May 2019]: 1-19 -
Joint Analysis of Metabolite Markers of Fish Intake and Persistent Organic Pollutants in Relation to Type 2 Diabetes Risk in Swedish Adults
Shi, L; Brunius, C; Bergdahl, IA; Johansson, I; Rolandsson, O; Donat Vargas, C; Kiviranta, H; Hanhineva, K; Åkesson, A; Landberg, R. 2019. Journal of nutrition. 149: 1413-1423 -
Liver DNA methylation of FADS2 associates with FADS2 genotypex
Walle, P; Männistö, V; de Mello, VD; Vaittinen, M; Perfilyev, A; Hanhineva, K; Ling, C; Pihlajamäki, J. 2019. Clinical epigenetics. 11: 10 -
Metabolic signature of extracellular vesicles depends on the cell culture conditions
Palviainen, Mari; Saari, Heikki; Kärkkäinen, Olli; Pekkinen, Jenna; Auriola, Seppo; Yliperttula, Marjo; Puhka, Maija; Hanhineva, Kati; Siljander, Pia R-M. 2019. Journal of extracellular vesicles. 8: 1596669 -
Plasma metabolite biomarkers of boiled and filtered coffee intake and their association with type 2 diabetes risk
Shi, L; Brunius, C; Johansson, I; Bergdahl, IA; Rolandsson, O; van Guelpen, B; Winkvist, A; Hanhineva, K; Landberg, R. 2019. Journal of internal medicine. 2020; 287: 405-421 -
Quantitative assessment of betainized compounds and associations with dietary and metabolic biomarkers in the randomized study of the healthy Nordic diet (SYSDIET)
Tuomainen, M; Kärkkäinen, O; Leppänen, J; Auriola, S; Lehtonen, M; Savolainen, MJ; Hermansen, K; Risérus, U; Åkesson, B; Thorsdottir, I; Kolehmainen, M; Uusitupa, M; Poutanen, K; Schwab, U; Hanhineva, K. 2019. American journal of clinical nutrition. 110: 1108-1118 -
Random forest-based imputation outperforms other methods for imputing LC-MS metabolomics data: a comparative study
Kokla, M; Virtanen, J; Kolehmainen, M; Paananen, J; Hanhineva, K. 2019. Bmc bioinformatics. 20: 492 -
Total liver phosphatidylcholine content associates with non-alcoholic steatohepatitis and glycine N-methyltransferase expression
Männistö, V; Kaminska, D; Kärjä, V; Tiainen, M; de Mello, VD; Hanhineva, K; Soininen, P; Ala-Korpela, M; Pihlajamäki, J. 2019. Liver international. 39: 1895-1905 -
A Non-Targeted LC-MS Profiling Reveals Elevated Levels of Carnitine Precursors and Trimethylated Compounds in the Cord Plasma of Pre-Eclamptic Infants
Jääskeläinen, Tiina; Kärkkäinen, Olli; Jokkala, Jenna; Litonius, Kaisa; Heinonen, Seppo; Auriola, Seppo; Lehtonen, Marko; Hanhineva, Kati; Laivuori, Hannele; FINNPEC. 2018. Scientific reports. 8: 14616 -
Alcohol and substance use are associated with altered metabolome in the first trimester serum samples of pregnant mothers
Lehikoinen, Anni I; Kärkkäinen, Olli K; Lehtonen, Marko AS; Auriola, Seppo OK; Hanhineva, Kati J; Heinonen, Seppo T. 2018. European journal of obstetrics and gynecology and reproductive biology. 223: 79-84 -
Associations of serum indolepropionic acid, a gut microbiota metabolite, with type 2 diabetes and low-grade inflammation in high-risk individuals
Tuomainen, Marjo; Lindström, Jaana; Lehtonen, Marko; Auriola, Seppo; Pihlajamäki, Jussi; Peltonen, Markku; Tuomilehto, Jaakko; Uusitupa, Matti; de Mello, Vanessa D; Hanhineva, Kati. 2018. Nutrition and diabetes. 8: 35 -
Diets rich in whole grains increase betainized compounds associated with glucose metabolism
Kärkkäinen, O; Lankinen, MA; Vitale, M; Jokkala, J; Leppänen, J; Koistinen, V; Lehtonen, M; Giacco, R; Rosa-Sibakov, N; Micard, V; Rivellese, AAA; Schwab, U; Mykkänen, H; Uusitupa, M; Kolehmainen, M; Riccardi, G; Poutanen, K; Auriola, S; Hanhineva, K. 2018. American journal of clinical nutrition. 108: 971-979 -
Fearful dogs have increased plasma glutamine and gamma-glutamyl glutamine
Puurunen, Jenni; Tiira, Katriina; Vapalahti, Katarooma; Lehtonen, Marko; Hanhineva, Kati; Lohi, Hannes. 2018. Scientific reports. 8: 15976 -
HX600, a synthetic agonist for RXR-Nurr1 heterodimer complex, prevents ischemia-induced neuronal damage
Loppi, S; Kolosowska, N; Kärkkäinen, O; Korhonen, P; Huuskonen, M; Grubman, A; Dhungana, H; Wojciechowski, S; Pomeshchik, Y; Giordano, M; Kagechika, H; White, A; Auriola, S; Koistinaho, J; Landreth, G; Hanhineva, K; Kanninen, K; Malm, T. 2018. Brain behavior and immunity. 73: 670-681 -
Heart specific PGC-1[alfa] deletion identifies metabolome of cardiac restricted metabolic heart failure
Kärkkäinen, Olli; Tuomainen, Tomi; Mutikainen, Maija; Lehtonen, Marko; Ruas, Jorge L; Hanhineva, Kati; Tavi, Pasi. 2018. Cardiovascular research. 2019; 115: 107-118 -
High-Fat Diet, Betaine, and Polydextrose Induce Changes in Adipose Tissue Inflammation and Metabolism in C57BL/6J Mice
Airaksinen, Kaisa; Jokkala, Jenna; Ahonen, Ilmari; Auriola, Seppo; Kolehmainen, Marjukka; Hanhineva, Kati; Tiihonen, Kirsti. 2018. Molecular nutrition and food research. 62: 1800455 -
Impact of location on composition of selected phytochemicals in wild sea buckthorn (Hippophae rhamnoides)
Madawala, Samanthi R P; Brunius, Carl; Adholeya, Alok; Tripathi, Shashi Bhushan; Hanhineva, Kati; Hajazimi, Ensieh; Shi, Lin; Dimberg, Lena; Landberg, Rikard. 2018. Journal of food composition and analysis. 72: 115-121 -
Interlaboratory Coverage Test on Plant Food Bioactive Compounds and their Metabolites by Mass Spectrometry-Based Untargeted Metabolomics
Koistinen, VM; da Silva, AB; Abrankó, L; Low, D; Villalba, RG; Barberán, FT; Landberg, R; Savolainen, O; Alvarez-Acero, I; de Pascual-Teresa, S; Van Poucke, C; Almeida, C; Petrásková, L; Valentová, K; Durand, S; Wiczkowski, W; Szawara-Nowak, D; González-Domínguez, R; Llorach, R; Andrés-Lacueva, C; et al.. 2018. Metabolites. 8: 46 -
Mastication-induced release of compounds from rye and wheat breads to saliva
Pentikäinen, Saara; Koistinen, Ville; Kolehmainen, Marjukka; Poutanen, Kaisa; Hanhineva, Kati; Aura, Anna-Marja. 2018. Food chemistry. 2019; 270: 502-508 -
Metabolic Profiling of High Egg Consumption and the Associated Lower Risk of Type 2 Diabetes in Middle-Aged Finnish Men
Noerman, S; Kärkkäinen, O; Mattsson, A; Paananen, J; Lehtonen, M; Nurmi, T; Tuomainen, TP; Voutilainen, S; Hanhineva, K; Virtanen, JK. 2018. Molecular nutrition and food research. 2019; 63: 1800605 -
Metabolic profiling of sourdough fermented wheat and rye bread
Koistinen, VM; Mattila, O; Katina, K; Poutanen, K; Aura, AM; Hanhineva, K. 2018. Scientific reports. 8: 5684 -
Novel Biomarker Candidates for Febrile Neutropenia in Hematological Patients Using Nontargeted Metabolomics
Lappalainen, Marika; Jokkala, Jenna; Juutilainen, Auni; Hämäläinen, Sari; Koivula, Irma; Jantunen, Esa; Hanhineva, Kati; Pulkki, Kari. 2018. Disease markers. 2018: 6964529 -
Nutrimetabolomics: An Integrative Action for Metabolomic Analyses in Human Nutritional Studies
Ulaszewska, MM; Weinert, CH; Trimigno, A; Portmann, R; Andres Lacueva, C; Badertscher, R; Brennan, L; Brunius, C; Bub, A; Capozzi, F; Cialiè Rosso, M; Cordero, CE; Daniel, H; Durand, S; Egert, B; Ferrario, PG; Feskens, EJM; Franceschi, P; Garcia-Aloy, M; Giacomoni, F; et al [Incl Hanhineva, K]. 2018. Molecular nutrition and food research. 2019; 63: 1800384 -
Plasma metabolites associated with healthy Nordic dietary indexes and risk of type 2 diabetes - a nested case-control study in a Swedish population
Shi, Lin; Brunius, Carl; Johansson, Ingegerd; Bergdahl, Ingbar A; Lindahl, Bernt; Hanhineva, Kati; Landberg, Rikard. 2018. American journal of clinical nutrition. 108: 564-575 -
Plasma metabolites associated with type 2 diabetes in a Swedish population: a case-control study nested in a prospective cohort
Shi, L; Brunius, C; Lehtonen, M; Auriola, S; Bergdahl, IA; Rolandsson, O; Hanhineva, K; Landberg, R. 2018. Diabetologia. 61: 849-861 -
Rye and health - Where do we stand and where do we go?
Jonsson, Karin; Andersson, Roger; Bach Knudsen, Knud Erik; Hallmans, Göran; Hanhineva, Kati; Katina, Kati; Kolehmainen, Marjukka; Kyrø, Cecilie; Langton, Maud; Nordlund, Emilia; Lærke, Helle Nygaard; Olsen, Anja; Poutanen, Kajsa; Tjønneland, Anne; Landberg, Rikard. 2018. Trends in food science and technology. 79: 78-87 -
Whole grain intake associated molecule 5-aminovaleric acid betaine decreases ß-oxidation of fatty acids in mouse cardiomyocytes
Kärkkäinen, Olli; Tuomainen, Tomi; Koistinen, Ville; Tuomainen, Marjo; Leppänen, Jukka; Laitinen, Tuomo; Lehtonen, Marko; Rysä, Jaana; Auriola, Seppo; Poso, Antti; Tavi, Pasi; Hanhineva, Kati. 2018. Scientific reports. 8: 13036 -
Effect of Bioprocessing on the In Vitro Colonic Microbial Metabolism of Phenolic Acids from Rye Bran Fortified Breads
Koistinen VM, Nordlund E, Katina K, Mattila I, Poutanen K, Hanhineva K, Aura A-M. 2017. Journal of agricultural and food chemistry. 65: 1854-1864 -
Fasting serum hippuric acid is elevated after bilberry (Vaccinium myrtillus) consumption and associates with improvement of fasting glucose levels and insulin secretion in persons at high risk of developing type 2 diabetes
de Mello VD, Lankinen MA, Lindström J, Puupponen-Pimiä R, Laaksonen DE, Pihlajamäki J, Lehtonen M, Uusitupa M, Tuomilehto J, Kolehmainen M, Törrönen R, Hanhineva K. 2017. Molecular nutrition and food research. 61: 1700019 -
Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study
de Mello VD, Paananen J, Lindstrom J, Lankinen MA, Shi L, Kuusisto J, Pihlajamaki J, Auriola S, Lehtonen M, Rolandsson O, Bergdahl IA, Nordin E, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Landberg R, Eriksson JG, Tuomilehto J, Hanhineva K, Uusitupa M. 2017. Scientific reports. 7: 46337 -
Mass spectrometry-based analysis of whole-grain phytochemicals
Koistinen Ville Mikael, Hanhineva Kati. 2017. Critical reviews in food science and nutrition. 57: 1688-1709 -
Metabolomics Applications in Herbal Medicine
Hanhineva Kati, Pasanen Markku. Teoksessa: Pelkonen O, Duez P, Vuorela P, Vuorela H(toim.) , 2017. Toxicology of Herbal Products. s. 165-178. Springer -
Microbial and endogenous metabolic conversions of rye phytochemicals
Koistinen Ville M, Hanhineva Kati. 2017. Molecular nutrition and food research. 61: 1600627 -
A non-targeted metabolite profiling pilot study suggests that tryptophan and lipid metabolisms are linked with ADHD-like behaviours in dogs
Puurunen Jenni, Sulkama Sini, Tiira Katriina, Araujo Cesar, Lehtonen Marko, Hanhineva Kati, Lohi Hannes. 2016. Behavioral and brain functions. 12: 27 -
Changes in the phytochemical profile of rye bran induced by enzymatic bioprocessing and sourdough fermentation
Koistinen Ville Mikael, Katina Kati, Nordlund Emilia, Poutanen Kaisa, Hanhineva Kati. 2016. Food research international. 89: 1106-1115 -
Metabolic profiling discriminates between strawberry (Fragaria×ananassa Duch.) cultivars grown in Finland or Estonia
Kårlund Anna, Moor Ulvi, McDougall Gordon, Lehtonen Marko, Karjalainen Reijo O, Hanhineva Kati. 2016. Food research international. 89: 647-653 -
Non-targeted metabolite profiling highlights the potential of strawberry leaves as a resource for specific bioactive compounds
Kårlund Anna, Hanhineva Kati, Lehtonen Marko, McDougall Gordon J, Stewart Derek, Karjalainen Reijo O. 2016. Journal of the science of food and agriculture. 2017; 97: 2182-2190 -
Non-targeted metabolite profiling reveals changes in oxidative stress, tryptophan and lipid metabolisms in fearful dogs
Puurunen Jenni, Tiira Katriina, Lehtonen Marko, Hanhineva Kati, Lohi Hannes. 2016. Behavioral and brain functions. 12: 7 -
Reduction in cardiometabolic risk factors by a multifunctional diet is mediated via several branches of metabolism as evidenced by non-targeted metabolite profiling approach
Tovar Juscelino, de Mello Vanessa D, Nilsson Anne, Johansson Maria, Paananen Jussi, Lehtonen Marko, Hanhineva Kati, Björck Inger. 2016. Molecular nutrition and food research. [Epub ahead of print 8 Nov 2016]: 1-12 -
Amino acid-derived betaines dominate as urinary markers for rye bran intake in mice fed high-fat diet - a non-targeted metabolomics study
Pekkinen Jenna, Rosa-Sibakov Natalia, Micard Valerie, Keski-Rahkonen Pekka, Lehtonen Marko, Poutanen Kaisa, Mykkänen Hannu, Hanhineva Kati. 2015. Molecular nutrition and food research. 59: 1550-1562 -
Application of Metabolomics to Assess Effects of Controlled Dietary Interventions
Hanhineva Kati. 2015. Current nutrition reports. 4: 365-376 -
CMPF Does Not Associate with Impaired Glucose Metabolism in Individuals with Features of Metabolic Syndrome
Lankinen Maria A., Hanhineva Kati, Kolehmainen Marjukka, Lehtonen Marko, Auriola Seppo, Mykkänen Hannu, Poutanen Kaisa, Schwab Ursula, Uusitupa Matti. 2015. PLoS ONE. 10: e0124379 -
Discovery of urinary biomarkers of whole grain rye intake in free-living subjects using non-targeted LC-MS metabolite profiling
Hanhineva Kati, Brunius Carl, Andersson Agneta, Marklund Matti, Juvonen Risto, Keski-Rahkonen Pekka, Auriola Seppo, Landberg Rikard. 2015. Molecular nutrition and food research. [epub ahead of print 10 SEP 2015]: - -
Effects of short- and long-term Mediterranean-based dietary treatment on plasma LC-QTOF/MS metabolic profiling of subjects with metabolic syndrome features: The Metabolic Syndrome Reduction in Navarra (RESMENA) randomized controlled trial
Bondia-Pons Isabel, Alfredo Martinez Jose, de la Iglesia Rocio, Lopez-Legarrea Patricia, Poutanen Kaisa, Hanhineva Kati, de los Angeles Zulet Maria. 2015. Molecular nutrition and food research. 59: 711-728 -
Glycosylated Benzoxazinoids Are Degraded during Fermentation of Wheat Bran
Savolainen Otto, Pekkinen Jenna, Katina Kati, Poutanen Kaisa, Hanhineva Kati. 2015. Journal of agricultural and food chemistry. 63: 5943-5949 -
Nontargeted Metabolite Profiles and Sensory Properties of Strawberry Cultivars Grown both Organically and Conventionally
Kårlund Anna, Hanhineva Kati, Lehtonen Marko, Karjalainen Reijo O, Sandell Mari. 2015. Journal of agricultural and food chemistry. 63: 1010-1019 -
Benzoxazinoids in rye and rye-derived products
Hanhineva K, Pihlava J, Mykkänen H, Poutanen K. Teoksessa: Poutanen Kaisa, Åman Per(toim.) , 2014. Rye and health. s. 121-129. AACC International -
Bioavailability of rye lignans and their relevance for human health
Penalvo José L, Hanhineva Kati, Adlercreutz Herman. Teoksessa: Poutanen Kaisa, Åman Per(toim.) , 2014. Rye and health. s. 71-84. AACC International -
Disintegration of wheat aleurone structure has an impact on the bioavailability of phenolic compounds and other phytochemicals as evidenced by altered urinary metabolite profile of diet-induced obese mice
Pekkinen Jenna, Rosa Natalia N, Savolainen Otto-Ilari, Keski-Rahkonen Pekka, Mykkänen Hannu, Poutanen Kaisa, Micard Valérie, Hanhineva Kati. 2014. Nutrition and metabolism. 11: 1-15 -
Impact of Wheat Aleurone Structure on Metabolic Disorders Caused by a High-Fat Diet in Mice
Rosa Natalia Nicole, Pekkinen Jenna, Zavala Karla, Fouret Gilles, Korkmaz Ayhan, Feillet-Coudray Christine, Atalay Mustafa, Hanhineva Kati, Mykkänen Hannu, Poutanen Kaisa, Micard Valérie. 2014. Journal of agricultural and food chemistry. 62: 10101-9 -
Metabolic profiling of Goji berry extracts for discrimination of geographical origin by non-targeted liquid chromatography coupled to quadrupole time-of-flight mass spectrometry
Bondia-Pons Isabel, Savolainen Otto, Törrönen Riitta, Martinez J Alfredo, Poutanen Kaisa, Hanhineva Kati. 2014. Food research international. 63: 132-138 -
Nontargeted metabolite profiling discriminates diet-specific biomarkers for consumption of whole grains, fatty fish, and bilberries in a randomized controlled trial
Hanhineva Kati, Lankinen Maria A, Pedret Anna, Schwab Ursula, Kolehmainen Marjukka, Paananen Jussi, de Mello Vanessa, Sola Rosa, Lehtonen Marko, Poutanen Kaisa, Uusitupa Matti, Mykkänen Hannu. 2014. Journal of nutrition. 2015; 145: 7-17 -
The postprandial plasma rye fingerprint includes benzoxazinoid-derived phenylacetamide sulfates
Hanhineva Kati, Keski-Rahkonen Pekka, Lappi Jenni, Katina Kati, Pekkinen Jenna, Savolainen Otto, Timonen Oskari, Paananen Jussi, Mykkänen Hannu, Poutanen Kaisa. 2014. Journal of nutrition. 144: 1016-22 -
The role of oxygen in the liquid fermentation of wheat bran
Savolainen Otto I, Coda Rossana, Suomi Katja, Katina Kati, Juvonen Riikka, Hanhineva Kati, Poutanen Kaisa. 2014. Food chemistry. 153: 424-431 -
Betaine supplementation causes increase in carnitine metabolites in the muscle and liver of mice fed a high-fat diet as studied by nontargeted LC-MS metabolomics approach
Pekkinen Jenna, Olli Kaisa, Huotari Anne, Tiihonen Kirsti, Keski-Rahkonen Pekka, Lehtonen Marko, Auriola Seppo, Kolehmainen Marjukka, Mykkänen Hannu, Poutanen Kaisa, Hanhineva Kati. 2013. Molecular nutrition and food research. 57: 1959-1968 -
Comparative nontargeted profiling of metabolic changes in tissues and biofluids in high-fat diet-fed Ossabaw pig
Hanhineva K, Barri T, Kolehmainen M, Pekkinen J, Pihlajamäki J, Vesterbacka A, Solano-Aguilar G, Mykkänen H, Dragsted LO, Urban JF, Poutanen K. 2013. Journal of proteome research. 12: 3980-3992 -
UPLC-QTOF/MS metabolic profiling unveils urinary changes in humans after a whole grain rye versus refined wheat bread intervention
Bondia-Pons I, Barri T, Hanhineva K, Juntunen K, Dragstedt LO, Mykkänen H, Poutanen K. 2013. Molecular nutrition and food research. 57: 412-422 -
In Vitro Microbiotic Fermentation Causes an Extensive Metabolite Turnover of Rye Bran Phytochemicals
Hanhineva K, Aura A-M, Rogachev I, Matero S, Skov T, Aharoni A, Poutanen K, Mykkänen H. 2012. PLoS ONE. 7: e39322 -
Metabolomics reveals the metabolic shifts following an intervention with rye bread in postmenopausal women - a randomized control trial
Moazzami AA, Bondia-Pons I, Hanhineva K, Juntunen K, Antl N, Poutanen K, Mykkänen H. 2012. Nutrition journal. 11: 88- -
Identification of novel lignans in the whole grain rye bran by non-targeted LC-MS metabolic profiling
Hanhiveva Kati, Rogachev Ilana, Aura Anna-Marja, Aharoni Asaph, Poutanen Kaisa, Mykkänen Hannu. 2011. Metabolomics. 2011: Online, 1-11 -
Qualitative characterization of benzoxazinoid derivatives in whole grain rye and wheat by LC-MS metabolite profiling
Hanhineva K, Rogachev I, Aura AM, Aharoni A, Poutanen K, Mykkänen H. 2011. Journal of agricultural and food chemistry. 59: 921-927 -
Recent advances in strawberry metabolomics
Hanhineva Kati, Kärenlampi Sirpa O., Aharoni Asaph. Teoksessa: Husaini Amhad M.(toim.) , 2011. Genomics, Transgenics, Molecular Breeding and Biotechnology of Strawberry. s. 65-75. Universidad de Malaga, Mercado José A. -
Impact of dietary polyphenols on carbohydrate metabolism.
Hanhineva K, Törrönen R, Bondia-Pons I, Pekkinen J, Kolehmainen M, Mykkänen H, Poutanen K.. 2010. International journal of molecular medicine. 11: 1365-1402 -
NMR and UPLC-qTOF-MS/MS characterisation of novel phenylethanol derivates of phenylpropanoid glucosides from the leaves of strawberry (Fragaria x ananassa cv. Jonsok)
Hanhineva K, Soininen P, Anttonen MJ, Kokko H, Rogachev I, Aharoni A, Laatikainen R, Kärenlampi S. 2009. Phytochemical analysis. : 353-364 -
NMR and UPLC-qTOF-MS/MS characterisation of novel phenylethanol derivatives of phenylpropanoid glucosides from the leaves of strawberry (Fragaria x ananassa cv. Jonsok)
Hanhineva K, Soininen P, Anttonen MJ, Kokko H, Rogachev I, Aharoni A, Laatikainen R & Kärenlampi S. 2009. Phytochemical analysis. 20: 353-364 -
Stilbene synthase gene transfer caused alterations in the phenylpropanoid metabolism of transgenic strawberry (Fragaria x ananassa)
Hanhineva K, Kokko H, Siljanen H, Rogachev I, Aharoni A & Kärenlampi SO. 2009. Journal of experimental botany. 60: 2093-2106 -
Stilbene synthase gene transfer resulted in down regulation of endogenous chalcone synthase in strawberry (Fragaria x ananassa) and led to the identification of novel phenylpropanoid glucosides
Hanhineva K, Anttonen MJ, Kokko H, Soininen P, Laatikainen R, Kärenlampi S, Rogachev I, Aharoni A. Teoksessa: Hanke M-V, Dunemann F, Flachowsky H(toim.) , 2009. Proceedings of the First International Symposium on Biotechnology of Fruit Species Bioftechfruit 2008. s. 673-679. International Society for Horticultural Science -
Metabolic Engineering of Phenolic Biosynthesis Pathway and Metabolite Profiling of Strawberry (Fragaria x ananassa)
Hanhineva K. 2008. Kuopion yliopiston julkaisuja C. Luonnontieteet ja ympäristötieteet -
Generation of genetically modified strawberries in temporary immersion bioreactor system
Hanhineva K, Kokko H, Kärenlampi S. Teoksessa: Xu Z, Li J, Xue Y, Yang W(toim.) , 2007. Biotechnology and Sustainable Agriculture 2006 and Beyond. Proceedings of the 11th IAPTC&B Congress. s. 115-118. Springer -
Production of transgenic strawberries by temporary immersion bioreactor system and verification by TAIL-PCR
Hanhineva KJ, Kärenlampi SO. 2007. Bmc biotechnology. 7: -
Shoot regeneration from leaf explants of five strawberry (Fragaria x ananassa) cultivars in temporary immersion bioreactor system
Hanhineva K, Kokko H, Kärenlampi S. 2005. In vitro cellular and developmental biology: plant. 41: 826-831