Kimmo Jokivarsi

The protective PLCγ2-P522R variant mitigates Alzheimer’s disease-associated pathologies by enhancing beneficial microglial functions

Takalo, Mari; Jeskanen, Heli; Rolova, Taisia; Kervinen, Inka; Hellén, Marianna; Heikkinen, Sami; Koivisto, Hennariikka; Jokivarsi, Kimmo; Müller, Stephan A.; Koivumäki, Esa-Mikko; Mäkinen, Petra; Juopperi, Sini-Pauliina; Willman, Roosa-Maria; Sinisalo, Rosa; Hoffmann, Dorit; Jäntti, Henna; Peitz, Michael; Fließbach, Klaus; Kuulasmaa, Teemu; Natunen, Teemu; Kemppainen, Susanna; Poutiainen, Pekka; Leinonen, Ville; Malm, Tarja; Martiskainen, Henna; Ramirez, Alfredo; Haapasalo, Annakaisa; Lichtentha. 2025. Journal of neuroinflammation. 22: . 64 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

A PEG-assisted membrane coating to prepare biomimetic mesoporous silicon for PET/CT imaging of triple-negative breast cancer

Wen, Huang; Martínez, María Gómez; Happonen, Emilia; Qian, Jing; Vallejo, Vanessa Gómez; Mendazona, Helena Jorge; Jokivarsi, Kimmo; Scaravilli, Mauro; Latonen, Leena; Llop, Jordi; Lehto, Vesa-Pekka; Xu, Wujun. 2024. International journal of pharmaceutics. 652: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

A robust approach to make inorganic nanovectors biotraceable

Wen, Huang; Närvänen, Ale; Jokivarsi, Kimmo; Poutiainen, Pekka; Xu, Wujun; Lehto, Vesa-Pekka. 2022. International journal of pharmaceutics. 624: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Chronic hypometabolism in striatum and hippocampal network after traumatic brain injury and their relation with memory impairment – [18F]-FDG-PET and MRI 4 months after fluid percussion injury in rat

Yasmin, Amna; Jokivarsi, Kimmo; Poutiainen, Pekka; Pitkänen, Asla; Gröhn, Olli; Immonen, Riikka. 2022. Brain research. 1788: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Individual head models for estimating the TMS-induced electric field in rat brain

Koponen, Lari M; Stenroos, Matti; Nieminen, Jaakko O; Jokivarsi, Kimmo; Gröhn, Olli; Ilmoniemi, Risto J. 2020. Scientific reports. 10: 17397 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

The Alzheimer's disease-associated protective Plcγ2-P522R variant promotes immune functions

Takalo, Mari; Wittrahm, Rebekka; Wefers, Benedikt; Parhizkar, Samira; Jokivarsi, Kimmo; Kuulasmaa, Teemu; Mäkinen, Petra; Martiskainen, Henna; Wurst, Wolfgang; Xiang, Xianyuan; Marttinen, Mikael; Poutiainen, Pekka; Haapasalo, Annakaisa; Hiltunen, Mikko; Haass, Christian. 2020. Molecular neurodegeneration. 15: 52 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Determining T2 relaxation time and stroke onset relationship in ischaemic stroke within apparent diffusion coefficient-defined lesions. A user-independent method for quantifying the impact of stroke in the human brain

Knight, MJ; Damion, RA; McGarry, BL; Bosnell, R; Jokivarsi, KT; Gröhn, OHJ; Jezzard, P; Harston, GWJ; Carone, D; Kennedy, J; El-Tawil, S; Elliot, J; Muir, KW; Clatworthy, P; Kauppinen, RA. 2019. Biomedical spectroscopy and imaging. 8: 11-28 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

MRS Reveals Chronic Inflammation in T2w MRI-Negative Perilesional Cortex - A 6-Months Multimodal Imaging Follow-Up Study

Yasmin, Amna; Pitkänen, Asla; Jokivarsi, Kimmo; Poutiainen, Pekka; Gröhn, Olli; Immonen, Riikka. 2019. Frontiers in neuroscience. 13: 863 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Awake Rat Brain Functional Magnetic Resonance Imaging Using Standard Radio Frequency Coils and a 3D Printed Restraint Kit

Stenroos, Petteri; Paasonen, Jaakko; Salo, Raimo A; Jokivarsi, Kimmo; Shatillo, Artem; Tanila, Heikki; Gröhn, Olli. 2018. Frontiers in neuroscience. 12: 548 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Impaired mitochondrial fatty acid synthesis leads to neurodegeneration in mice

Nair, Remya R; Koivisto, Henna; Jokivarsi, Kimmo; Miinalainen, Ilkka J; Autio, Kaija J; Manninen, Aki; Poutiainen, Pekka; Tanila, Heikki; Hiltunen, J Kalervo; Kastaniotis, Alexander J. 2018. Journal of neuroscience. 38: 9781-9800 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Intranasal insulin activates Akt2 signaling pathway in the hippocampus of wild-type but not in APP/PS1 Alzheimer model mice

Gabbouj, S; Natunen, T; Koivisto, H; Jokivarsi, K; Takalo, M; Marttinen, M; Wittrahm, R; Kemppainen, S; Naderi, R; Posado-Fernández, A; Ryhänen, S; Mäkinen, P; Paldanius, KMA; Doria, G; Poutiainen, P; Flores, O; Haapasalo, A; Tanila, H; Hiltunen, M. 2018. Neurobiology of aging. 2019; 75: 98-108 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Loss of NRF-2 and PGC-1[alpha] genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration

Felszeghy, S; Viiri, J; Paterno, JJ; Hyttinen, JMT; Koskela, A; Chen, M; Leinonen, H; Tanila, H; Kivinen, N; Koistinen, A; Toropainen, E; Amadio, M; Smedowski, A; Reinisalo, M; Winiarczyk, M; Mackiewicz, J; Mutikainen, M; Ruotsalainen, AK; Kettunen, M; Jokivarsi, K; et al [Incl Kaarniranta, K; Kauppinen, A; Kinnunen, K; Levonen, A-L; Salminen, A; Tavi, P-P; Urtti, A]. 2018. Redox biology. 2019; 20: 1-12 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia

McGarry BL, Jokivarsi KT, Knight MJ, Grohn OHJ, Kauppinen RA. 2017. Journal of visualized experiments. 127: 1-6 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Stroke onset time determination using MRI relaxation times without non-ischaemic reference in a rat stroke model

Norton Terence JT, Pereyra Marcelo, Knight Michael J, McGarry Bryony M, Jokivarsi Kimmo T, Grohn Olli HJ, Kauppinen Risto A. 2017. Biomedical spectroscopy and imaging. 6: 25-35 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

A spatiotemporal theory for MRI T2 relaxation time and apparent diffusion coefficient in the brain during acute ischaemia: application and validation in a rat acute stroke model

Knight MJ, Mcgarry BL, Rogers HJ, Jokivarsi KT, Gröhn OHJ, Kauppinen RA. 2016. Journal of cerebral blood flow and metabolism. 36: 1232-1243 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Determining stroke onset time using quantitative MRI: High accuracy, sensitivity and specificity obtained from magnetic resonance relaxation times

McGarry BL, Rogers HJ, Knight MJ, Jokivarsi KT, Gröhn OHJ, Kauppinen RA. 2016. Cerebrovascular diseases extra. 6: 60-65 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Implantable RF-coil with multiple electrodes for long-term EEG-fMRI monitoring in rodents

Pirttimäki T, Salo RA, Shatillo A, Kettunen MI, Paasonen J, Sierra A, Jokivarsi K, Leinonen V, Andrade P, Quittek S, Pitkänen A, Gröhn O. 2016. Journal of neuroscience methods. 274: 154-163 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Stroke onset time estimation from multispectral quantitative magnetic resonance imaging in a rat model of focal permanent cerebral ischemia

McGarry BL, Rogers HJ, Knight MJ, Jokivarsi KT, Sierra A, Gröhn OHJ, Kauppinen RA. 2016. International journal of stroke. 11: 677-82 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

PET imaging studies show enhanced expression of mGluR5 and inflammatory response during progressive degeneration in ALS mouse model expressing SOD1-G93A gene

Brownell AL, Kuruppu D, Kil KE, Jokivarsi K, Poutiainen P, Zhu A, Maxwell M. 2015. Journal of neuroinflammation. 12: 217 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Enables the Detection of Recurrent Same-Site Deep Vein Thrombosis by Illuminating Recently Formed, Neutrophil-Rich Thrombus

Hara Tetsuya, Truelove Jessica, Tawakol Ahmed, Wojtkiewicz Gregory R, Hucker William J, MacNabb Megan H, Brownell Anna-Liisa, Jokivarsi Kimmo, Kessinger Chase W, Jaff Michael R, Henke Peter K, Weissleder Ralph, Jaffer Farouc A. 2014. Circulation. : 1044-52 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Timing the ischaemic stroke by 1H-MRI: improved accuracy using absolute relaxation times over signal intensities

Rogers Harriet J, McGarry Bryony L, Knight Michael J, Jokivarsi Kimmo T, Gröhn Olli H, Kauppinen Risto A. 2014. Neuroreport. 2014 Oct 22;25(15): 1180-1185 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

High efficiency diffusion molecular retention tumor targeting

Guo Y, Yuan H, Cho H, Kuruppu D, Jokivarsi K, Agarwal A, Shah K, Josephson L. 2013. PLoS ONE. : e58290 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

In vivo magnetic resonance imaging and spectroscopy identifies oncolytic adenovirus responders

Hemminki O, Immonen R, Närväinen J, Kipar A, Paasonen J, Jokivarsi KT, Yli-Ollila H, Soininen P, Partanen K, Joensuu T, Parvianen S, Pesonen SK, Koski A, Vähä-Koskela M, Cerullo V, Pesonen S, Gröhn OH, Hemminki A. 2013. International journal of cancer. 6 DEC 2013: -- A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Relaxation Along a Fictitious Field (RAFF) and Z-spectroscopy using Alternating-Phase Irradiation (ZAPI) in Permanent Focal Cerebral Ischemia in Rat

Jokivarsi KT, Liimatainen T, Kauppinen RA, Gröhn OH, Närväinen J. 2013. PLoS ONE. 2013 Jul 17;8(7):e69157: -- A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Probing Water Dynamics in Acute Cerebral Ischemia by MRI

Jokivarsi K. 2009. Kuopion yliopiston julkaisuja G.- A.I. Virtanen -instituutti G5 Artikkeliväitöskirja

Quantitative assessment of water pools by T1rho and T2rho MRI in acute cerebral ischemia of the rat

Jokivarsi KT, Niskanen J-P, Michaeli S, Gröhn HI, Garwood M, Kauppinen RA, Gröhn OH. 2009. Journal of cerebral blood flow and metabolism. 29: 206-216 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Proton transfer ratio, lactate, and intracellular pH in acute cerebral ischemia

Jokivarsi KT, Gröhn HI, Gröhn OH, Kauppinen RA. 2007. Magnetic resonance in medicine. 57: 647-653 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Subacute hemorrhage and resolution of edema in Rose Bengal stroke model in rats coincides with improved sensorimotor functions

Jolkkonen J, Jokivarsi K, Laitinen T, Gröhn O. 2007. Neuroscience letters. 428: 99-102 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Tarkenna hakuasi

Tutkimusryhmät

Julkaisut

The protective PLCγ2-P522R variant mitigates Alzheimer’s disease-associated pathologies by enhancing beneficial microglial functions

A PEG-assisted membrane coating to prepare biomimetic mesoporous silicon for PET/CT imaging of triple-negative breast cancer

A robust approach to make inorganic nanovectors biotraceable

Chronic hypometabolism in striatum and hippocampal network after traumatic brain injury and their relation with memory impairment – [18F]-FDG-PET and MRI 4 months after fluid percussion injury in rat

Individual head models for estimating the TMS-induced electric field in rat brain

The Alzheimer's disease-associated protective Plcγ2-P522R variant promotes immune functions

Determining T2 relaxation time and stroke onset relationship in ischaemic stroke within apparent diffusion coefficient-defined lesions. A user-independent method for quantifying the impact of stroke in the human brain

MRS Reveals Chronic Inflammation in T2w MRI-Negative Perilesional Cortex - A 6-Months Multimodal Imaging Follow-Up Study

Awake Rat Brain Functional Magnetic Resonance Imaging Using Standard Radio Frequency Coils and a 3D Printed Restraint Kit

Impaired mitochondrial fatty acid synthesis leads to neurodegeneration in mice

Intranasal insulin activates Akt2 signaling pathway in the hippocampus of wild-type but not in APP/PS1 Alzheimer model mice

Loss of NRF-2 and PGC-1[alpha] genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration

A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia

Stroke onset time determination using MRI relaxation times without non-ischaemic reference in a rat stroke model

A spatiotemporal theory for MRI T2 relaxation time and apparent diffusion coefficient in the brain during acute ischaemia: application and validation in a rat acute stroke model

Determining stroke onset time using quantitative MRI: High accuracy, sensitivity and specificity obtained from magnetic resonance relaxation times

Implantable RF-coil with multiple electrodes for long-term EEG-fMRI monitoring in rodents

Stroke onset time estimation from multispectral quantitative magnetic resonance imaging in a rat model of focal permanent cerebral ischemia

PET imaging studies show enhanced expression of mGluR5 and inflammatory response during progressive degeneration in ALS mouse model expressing SOD1-G93A gene

18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Enables the Detection of Recurrent Same-Site Deep Vein Thrombosis by Illuminating Recently Formed, Neutrophil-Rich Thrombus

Timing the ischaemic stroke by 1H-MRI: improved accuracy using absolute relaxation times over signal intensities

High efficiency diffusion molecular retention tumor targeting

In vivo magnetic resonance imaging and spectroscopy identifies oncolytic adenovirus responders

Relaxation Along a Fictitious Field (RAFF) and Z-spectroscopy using Alternating-Phase Irradiation (ZAPI) in Permanent Focal Cerebral Ischemia in Rat

Probing Water Dynamics in Acute Cerebral Ischemia by MRI

Quantitative assessment of water pools by T1rho and T2rho MRI in acute cerebral ischemia of the rat

Proton transfer ratio, lactate, and intracellular pH in acute cerebral ischemia

Subacute hemorrhage and resolution of edema in Rose Bengal stroke model in rats coincides with improved sensorimotor functions