KIRSI RILLA

Yhteystiedot

Tutkimusryhmät

• Rilla group
• Solu- ja kudoskuvantamisen yksikkö

Julkaisut

• Aaltonen, Niina; Singha, Prosanta; Jakupovic, Hermina; Wirth, Thomas; Samaranayake, Haritha; Pasonen-Seppänen, Sanna; Rilla, Kirsi; Varjosalo, Markku; Edgington-Mitchell, Laura; Kasperkiewicz, Paulina; Drag, Marcin; Kälvälä, Sara; Moisio, Eemeli; Savinainen, Juha; Laitinen, Jarmo. 2020. High-Resolution Confocal Fluorescence Imaging of Serine Hydrolase Activity in Cryosections - Application to Glioma Brain Unveils Activity Hotspots Originating from Tumor-Associated Neutrophils Biological procedures online 22: 6. 2020
• Marttinen, Mikael; Ferreira, Catarina B; Paldanius, Kaisa M A; Takalo, Mari; Natunen, Teemu; Mäkinen, Petra; Leppänen, Luukas; Leinonen, Ville; Tanigaki, Kenji; Kang, Gina; Hiroi, Noboru; Soininen, Hilkka; Rilla, Kirsi; Haapasalo, Annakaisa; Hiltunen, Mikko. 2020. Presynaptic Vesicle Protein SEPTIN5 Regulates the Degradation of APP C-Terminal Fragments and the Levels of Aß Cells 9 11: 2482. 2020
• Matilainen, Johanna; Mustonen, Anne-Mari; Rilla, Kirsi; Käkelä, Reijo; Sihvo, Sanna; Nieminen, Petteri. 2020. Orotic acid-treated hepatocellular carcinoma cells resist steatosis by modification of fatty acid metabolism Lipids in health and disease 19 1: 70. 2020
• Tiainen, Satu; Rilla, Kirsi; Hämäläinen, Kirsi; Oikari, Sanna; Auvinen, Päivi. 2020. The prognostic and predictive role of the neutrophil-to-lymphocyte ratio and the monocyte-to-lymphocyte ratio in early breast cancer, especially in the HER2+ subtype Breast cancer research and treatment [Online ahead of print 2020 Sep 18]: 1-10. 2020
• Kyykallio, Heikki; Oikari, Sanna; Álvez, María Bueno; Dodd, Carlos José Gallardo; Capra, Janne; Rilla, Kirsi. 2020. The density and length of filopodia associate with the activity of hyaluronan synthesis in tumor cells Cancers 12 7: 1908. 2020
• Mustonen, Anne-Mari; Salvén, Anu; Kärjä, Vesa; Rilla, Kirsi; Matilainen, Johanna; Nieminen, Petteri. 2019. Hyaluronan histochemistry - A potential new tool to assess the progress of liver disease from simple steatosis to hepatocellular carcinoma Glycobiology 29 4: 298-306. 2019
• Tiainen, S; Masarwah, A; Oikari, S; Rilla, K; Hämäläinen, K; Sudah, M; Sutela, A; Vanninen, R; Ikonen, J; Tammi, R; Tammi, M; Auvinen, P. 2019. Tumor microenvironment and breast cancer survival: combined effects of breast fat, M2 macrophages and hyaluronan create a dismal prognosis Breast cancer research and treatment 2020; 179: 565-575. 2019
• Tammi, Markku I; Oikari, Sanna; Pasonen-Seppänen, Sanna; Rilla, Kirsi; Auvinen, Päivi; Tammi, Raija H. 2019. Activated hyaluronan metabolism in the tumor matrix - Causes and consequences Matrix biology 78-79: 147-164. 2019
• Rilla, Kirsi; Mustonen, Anne-Mari; Thanigai, Arasu Uma; Härkönen, Kai; Matilainen, Johanna; Nieminen, Petteri. 2019. Extracellular vesicles are integral and functional components of the extracellular matrix Matrix biology 75-76: 201-219. 2019
• Melero-Fernandez de Mera, RM; Arasu, UT; Kärnä, R; Oikari, S; Rilla, K; Vigetti, D; Passi, A; Heldin, P; Tammi, MI; Deen, AJ. 2019. Effects of mutations in the post-translational modification sites on the trafficking of hyaluronan synthase 2 (HAS2) Matrix biology 80: 85-103. 2019
• Härkönen, K; Oikari, S; Kyykallio, H; Capra, J; Hakkola, S; Ketola, K; Thanigai Arasu, U; Daaboul, G; Malloy, A; Oliveira, C; Jokelainen, O; Sironen, R; Hartikainen, JM; Rilla, K. 2019. CD44s Assembles Hyaluronan Coat on Filopodia and Extracellular Vesicles and Induces Tumorigenicity of MKN74 Gastric Carcinoma Cells Cells 8 3: 276. 2019
• Hellinen, Laura; Sato, Kazuki; Reinisalo, Mika; Kidron, Heidi; Rilla, Kirsi; Tachikawa, Masanori; Uchida, Yasuo; Terasaki, Tetsuya; Urtti, Arto. 2019. Quantitative Protein Expression in the Human Retinal Pigment Epithelium: Comparison Between Apical and Basolateral Plasma Membranes With Emphasis on Transporters Investigative ophthalmology and visual science 60 15: 5022-5034. 2019
• Arasu, UT; Deen, AJ; Pasonen-Seppänen, S; Heikkinen, S; Lalowski, M; Kärnä, R; Härkönen, K; Mäkinen, P; Lázaro-Ibáñez, E; Siljander, PR; Oikari, S; Levonen, AL; Rilla, K. 2019. HAS3-induced extracellular vesicles from melanoma cells stimulate IHH mediated c-Myc upregulation via the hedgehog signaling pathway in target cells Cellular and molecular life sciences [Published: 09 December 2019]: 1-23. 2019
• Arasu, Uma Thanigai; Härkönen, Kai; Koistinen, Arto; Rilla, Kirsi. 2019. Correlative light and electron microscopy is a powerful tool to study interactions of extracellular vesicles with recipient cells Experimental cell research 376 2: 149-158. 2019
• Karttunen, Jenni; Heiskanen, Mette; Navarro-Ferrandis, Vicente; Das Gupta, Shalini; Lipponen, Anssi; Puhakka, Noora; Rilla, Kirsi; Koistinen, Arto; Pitkänen, Asla. 2018. Precipitation-based extracellular vesicle isolation from rat plasma co-precipitate vesicle-free microRNAs Journal of Extracellular Vesicles 2019; 8 1: 1555410. 2018
• Valkonen, Mari; Haapasalo, Hannu; Rilla, Kirsi; Tyynelä-Korhonen, Kristiina; Soini, Ylermi; Pasonen-Seppänen, Sanna. 2018. Elevated expression of hyaluronan synthase 2 associates with decreased survival in diffusely infiltrating astrocytomas Bmc cancer 18 1: 664. 2018
• Arasu UT, Kärnä R, Härkönen K, Oikari S, Koistinen A, Kröger H, Qu C, Lammi MJ, Rilla K. 2017. Human mesenchymal stem cells secrete hyaluronan-coated extracellular vesicles. MATRIX BIOLOGY 64: 54-68. 2017
• Koistinen Ville, Härkönen Kai, Kärnä Riikka, Arasu Uma Thanigi, OIkari Sanna, Rilla Kirsi. 2017. EMT induced by EGF and wounding activates hyaluronan synthesis machinery and EV shedding in rat primary mesothelial cells. MATRIX BIOLOGY 63: 38-54. 2017
• Lazaro-Ibanez Elisa, Neuvonen Maarit, Takatalo Maarit, Arasu Uma Thanigai, Capasso Cristian, Cerullo Vincenzo, Rhim Johng S, Rilla Kirsi, Yliperttula Marjo, Siljander Pia R -M. 2017. Metastatic state of parent cells influences the uptake and functionality of prostate cancer cell-derived extracellular vesicles. Journal of Extracellular Vesicles 6 1: 1354645. 2017
• Martiskainen H, Paldanius KMA, Natunen T, Takalo M, Marttinen M, Leskelä S, Huber N, Mäkinen P, Bertling E, Dhungana H, Huuskonen M, Honkakoski P, Hotulainen P, Rilla K, Koistinaho J, Soininen H, Malm T, Haapasalo A, Hiltunen M. 2017. DHCR24 exerts neuroprotection upon inflammation-induced neuronal death. JOURNAL OF NEUROINFLAMMATION [HTTP://WWW.JNEUROINFLAMMATION.COM/] 14: 215. 2017
• Pesonen M, Rysä J, Storvik M, Rilla K, Pasanen M, Vähäkangas K. 2017. Molecular targets of chloropicrin in human airway epithelial cells. TOXICOLOGY IN VITRO 42: 247-254. 2017
• Tiainen Satu, Oikari Sanna, Tammi Markku, Rilla Kirsi, Hämäläinen Kirsi, Tammi Raija, Kosma Veli-Matti, Auvinen Päivi. 2016. High extent of O-GlcNAcylation in breast cancer cells correlates with the levels of HAS enzymes, accumulation of hyaluronan, and poor outcome. BREAST CANCER RESEARCH AND TREATMENT 160 2: 237-247. 2016
• Törrönen Kari, Soini Ylermi, Pääkkö Paavo, Parkkinen Jyrki, Sironen Reijo, Rilla Kirsi. 2016. Mesotheliomas show higher hyaluronan positivity around tumor cells than metastatic pulmonary adenocarcinomas. HISTOLOGY AND HISTOPATHOLOGY 31 10: 1113-1122. 2016
• Koistinen Ville, Jokela Tiina, Oikari Sanna, Kärnä Riikka, Tammi Markku, Rilla Kirsi. 2016. Hyaluronan-positive plasma membrane protrusions exist on mesothelial cells in vivo. HISTOCHEMISTRY AND CELL BIOLOGY 145 5: 531-544. 2016
• Rilla Kirsi, Hiltunen Mikko. 2016. Ekstrasellulaarivesikkelit tulevaisuuden biomarkkereina. BestPractice Psykiatria/neurologia: lääketieteen asiantuntijoiden ammattilehti 4 16 (Lokakuu 2016): 11-13. 2016
• Deen AJ, Arasu UT, Pasonen-Seppänen S, Hassinen A, Takabe P, Wojciechowski S, Kärnä R, Rilla K, Kellokumpu S, Tammi R, Tammi M, Oikari S. 2016. UDP-sugar substrates of HAS3 regulate its O-GlcNAcylation, intracellular traffic, extracellular shedding and correlate with melanoma progression. CELLULAR AND MOLECULAR LIFE SCIENCES: CMLS 73 16: 3183-3204. 2016
• Mustonen A-M, Nieminen P, Joukainen A, Jaroma A, Kääriäinen T, Kröger H, Lázaro-Ibáñez E, Siljander PR-M, Kärjä V, Härkönen K, Koistinen A, Rilla K. 2016. First in vivo detection and characterization of hyaluronan-coated extracellular vesicles in human synovial fluid. JOURNAL OF ORTHOPAEDIC RESEARCH 34 11: 1960-1968. 2016
• Jokela Tiina, Oikari Sanna, Takabe Piia, Rilla Kirsi, Kärnä Riikka, Tammi Markku, Tammi Raija. 2015. Interleukin-1ß-induced Reduction of CD44 Ser-325 Phosphorylation in Human Epidermal Keratinocytes Promotes CD44 Homomeric Complexes, Binding to Ezrin, and Extended, Monocyte-adhesive Hyaluronan Coats. JOURNAL OF BIOLOGICAL CHEMISTRY 290: 12379-12393. 2015
• Koistinen Ville, Kärnä Riikka, Koistinen Arto, Arjonen Antti, Tammi Markku, Rilla Kirsi. 2015. Cell protrusions induced by hyaluronan synthase 3 (HAS3) resemble mesothelial microvilli and share cytoskeletal features of filopodia. EXPERIMENTAL CELL RESEARCH 337 2: 179-191. 2015
• Rilla Kirsi, Koistinen Arto. 2015. Correlative Light and Electron Microscopy Reveals the HAS3-Induced Dorsal Plasma Membrane Ruffles. International Journal of Cell Biology 2015 Article ID 769163: 8 pages. 2015
• Siiskonen Hanna, Oikari Sanna, Pasonen-Seppänen Sanna, Rilla Kirsi. 2015. Hyaluronan synthase 1: a mysterious enzyme with unexpected functions. Frontiers in immunology epub. 2015
• Sokka Miiko, Rilla Kirsi, Miinalainen Ilkka, Pospiech Helmut, Syväoja Juhani E.. 2015. High levels of TopBP1 induce ATR-dependent shut-down of rRNA transcription and nucleolar segregation. NUCLEIC ACIDS RESEARCH 43 10: 4975-4989. 2015
• Takabe Piia, Bart Genevieve, Ropponen Antti, Rilla Kirsi, Tammi Markku, Tammi Raija, Pasonen-Seppanen Sanna. 2015. Hyaluronan synthase 3 (HAS3) overexpression downregulates MV3 melanoma cell proliferation, migration and adhesion. EXPERIMENTAL CELL RESEARCH 337 1: 1-15. 2015
• Rilla K, Koistinen AP. 2014. Correlative light and electron microscopy reveals the morphological changes of HAS3 overexpressing breast cancer cells and their hyaluronan-dependent plasma membrane protrusions: Linköping University, 65th Annual Conference of the Nordic Microscopy Society, Scandem 2014. http://www.trippus.se/eventus/userfiles/51916.pdf. 2014
• Tiainen Satu, Tumelius Ritva, Rilla Kirsi, Hämäläinen Kirsi, Tammi Markku, Tammi Raija, Kosma Veli-Matti, Oikari Sanna, Auvinen Päivi. 2014. High numbers of macrophages, especially M2-like (CD163-positive), correlate with hyaluronan accumulation and poor outcome in breast cancer. HISTOPATHOLOGY 2014; 66 6: 873-883. 2014
• Rilla Kirsi, Siiskonen Hanna, Tammi Markku, Tammi Raija. 2014. Hyaluronan-coated extracellular vesicles - a novel link between hyaluronan and cancer. Advances in cancer research 123: 121-148. 2014
• Deen Ashik Jawahar, Rilla Kirsi, Oikari Sanna, Kärnä Riikka, Bart Genevieve, Häyrinen Jukka, Bathina Avinash Rahul, Ropponen Antti, Makkonen Katri, Tammi Raija H, Tammi Markku I. 2014. Rab10-mediated endocytosis of the hyaluronan synthase HAS3 regulates hyaluronan synthesis and cell adhesion to collagen. JOURNAL OF BIOLOGICAL CHEMISTRY 289 12: 8375-89. 2014
• Qu C, Rilla K, Tammi R, Tammi M, Kröger H, Lammi MJ. 2014. Extensive CD44-dependent hyaluronan coats on human bone marrow-derived mesenchymal stem cells produced by hyaluronan synthases HAS1, HAS2 and HAS3. INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND CELL BIOLOGY 48: 45-54. 2014
• Pesonen Maija, Häkkinen Merja, Rilla Kirsi, Juvonen Risto, Kuitunen Tapio, Pasanen Markku, Vähäkangas Kirsi. 2014. Chloropicrin-induced toxic responses in human lung epithelial cells. TOXICOLOGY LETTERS 226: 236-244. 2014
• Karjalainen Hannu M, Qu Chengjuan, Leskelä Stina S, Rilla Kirsi, Lammi Mikko J. 2014. Chondrocytic cells express the taurine transporter on their plasma membrane and regulate its expression under anisotonic conditions. AMINO ACIDS 47 3: 561-570. 2014
• Auvinen Päivi, Rilla Kirsi, Tumelius Ritva, Tammi Markku, Sironen Reijo, Soini Ylermi, Kosma Veli-Matti, Mannermaa Arto, Viikari Jukka, Tammi Raija. 2014. Hyaluronan synthases (HAS1-3) in stromal and malignant cells correlate with breast cancer grade and predict patient survival. BREAST CANCER RESEARCH AND TREATMENT 143 2: 277-286. 2014
• Siiskonen H, Kärnä R, Hyttinen JM, Tammi RH, Tammi MI, Rilla K. 2013. Hyaluronan synthase 1 (HAS1) produces a cytokine- and glucose-inducible, CD44-dependent cell surface coat. EXPERIMENTAL CELL RESEARCH online: -. 2013
• Viiri J, Amadio M, Marchesi N, Hyttinen JM, Kivinen N, Sironen R, Rilla K, Akhtar S, Provenzani A, D'Agostino VG, Govoni S, Pascale A, Agostini H, Petrovski G, Salminen A, Kaarniranta K. 2013. Autophagy Activation Clears ELAVL1/HuR-Mediated Accumulation of SQSTM1/p62 during Proteasomal Inhibition in Human Retinal Pigment Epithelial Cells. PLOS ONE [ONLINE] 8 7: e6963, 16 pages. 2013
• Törrönen K, Nikunen K, Kärnä R, Tammi M, Tammi R, Rilla K. 2013. Tissue distribution and subcellular localization of hyaluronan synthase isoenzymes. HISTOCHEMISTRY AND CELL BIOLOGY 140 13: -. 2013
• Tuuminen R, Nykänen AI, Saharinen P, Gautam P, Keränen MA, Arnaudova R, Rouvinen E, Helin H, Tammi R, Rilla K, Krebs R, Lemström KB. 2013. Donor simvastatin treatment prevents ischemia-reperfusion and acute kidney injury by preserving microvascular barrier function. American Journal of Transplantation 13 8: 2019-34. 2013
• Hakkarainen Jenni J, Rilla Kirsi, Suhonen Marjukka, Ruponen Marika, Forsberg Markus M. 2013. Re-evaluation of the role of P-glycoprotein in in vitro drug permeability studies with the bovine brain microvessel endothelial cells. XENOBIOTICA (LONDON) 2014:44: 283-294. 2013
• Rilla K, Pasonen-Seppänen S, Deen AJ, Koistinen VVT, Wojciechowski S, Oikari S, Kärnä R, Bart G, Törrönen K, Tammi RH, Tammi MI. 2013. Hyaluronan production enhances shedding of plasma membrane-derived microvesicles. EXPERIMENTAL CELL RESEARCH 319 13: 2006-2018. 2013
• Högnäs G, Hämälistö S, Rilla K, Laine JO, Vilkki V, Murumägi A, Edgren H, Kallioniemi O, Ivaska J. 2013. Aneuploidy facilitates oncogenic transformation via specific genetic alterations, including Twist2 upregulation. CARCINOGENESIS Epub: e1-10. 2013
• Rilla K, Oikari S, Jokela TA, Hyttinen JMT, Kärnä R, Tammi RH, Tammi MI. 2013. Hyaluronan synthase 1 (HAS1) requires higher cellular UDP-GIcNAc concentration than HAS2 and HAS3. JOURNAL OF BIOLOGICAL CHEMISTRY 288 8: 5973-5983. 2013
• Jokela TA, Kuokkanen J, Kärnä R, Pasonen-Seppänen S, Rilla K, Kössi J, Laato M, Tammi RH, Tammi MI. 2013. Mannose reduces hyaluronan and leukocytes in wound granulation tissue and inhibits migration and hyaluronan-dependent monocyte binding. Wound Repair and Regeneration 21: 247-255. 2013
• Pasonen-Seppänen S, Hyttinen JM, Rilla K, Jokela T, Noble PW, Tammi M, Tammi R. 2012. Role of CD44 in the organization of keratinocyte pericellular hyaluronan HISTOCHEMISTRY AND CELL BIOLOGY 137: 107-120. 2012
• Pasonen-Seppänen S, Takabe P, Edward M, Rauhala L, Rilla K, Tammi M, Tammi R. 2012. Melanoma cell-derived factors stimulate hyaluronan in dermal fibroblasts by upregulating HAS2 through PDGFR-PI3K_AKT and p38 -signaling. HISTOCHEMISTRY AND CELL BIOLOGY 138 6: 895-911. 2012
• Siiskonen H, Rilla K, Kärnä R, Bart G, Jing W, Haller MF, DeAngelis PL, Tammi RH, Tammi MI. 2012. Hyaluronan in cytosol - microinjection-based probing of its existence and suggested functions. GLYCOBIOLOGY online: -. 2012
• Xu Wujun, Riikonen Joakim, Nissinen Tuomo, Suvanto Mika, Rilla Kirsi, Li Bojie, Wang Qiang, Deng Feng, Lehto Vesa-Pekka. 2012. Amine Surface Modifications and Fluorescent Labeling of Thermally Stabilized Mesoporous Silicon Nanoparticles. JOURNAL OF PHYSICAL CHEMISTRY. C 116 42: 22307-22314. 2012
• Rilla Kirsi, Pasonen-Seppänen Sanna, Kärnä Riikka, Karjalainen Hannu M, Törrönen Kari, Koistinen Ville, Tammi Markku I, Tammi Raija H, Teräväinen Terhi, Manninen Aki. 2011. HAS3-induced accumulation of hyaluronan in 3D MDCK cultures results in mitotic spindle misorientation and disturbed organization of epithelium HISTOCHEMISTRY AND CELL BIOLOGY 137 2: 153-164. 2011
• Tammi Raija H, Passi Alberto G, Rilla Kirsi, Karousou Evgenia, Vigetti Davide, Makkonen Katri, Tammi Markku I. 2011. Transcriptional and post-translational regulation of hyaluronan synthesis. FEBS JOURNAL 278 9: 1- 10. 2011
• Siiskonen Hanna, Törrönen Kari, Kumlin Timo, Rilla Kirsi, Tammi Markku I, Tammi Raija H. 2011. Chronic UVR Causes Increased Immunostaining of CD44 and Accumulation of Hyaluronan in Mouse Epidermis JOURNAL OF HISTOCHEMISTRY AND CYTOCHEMISTRY 59 10: 908-917. 2011
• Kultti A, Kärnä R, Rilla K, Nurminen P, Koli E, Makkonen KM, Si J, Tammi MI & Tammi R. 2010. Methyl-β-cyclodetextrin suppresses hyaluronan synthesis by down-regulation of hyaluronan synthase 2 through inhibition of Akt. JOURNAL OF BIOLOGICAL CHEMISTRY 285 30: 22901-22910. 2010
• Nykopp TK, Rilla K, Tammi MI, Tammi RH, Sironen R, Hämäläinen K, Kosma V-M, Heinonen S & Anttila M. 2010. Hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma BMC CANCER 10: 512. 2010
• Rilla K, Tammi M & Tammi R. 2010. The enigma of hyaluronan-synthesizing membrane protrusions and hyaluronan coats. GlycoForum HA35: 1-10. 2010
• Rilla Kirsi, Tammi Markku, Tammi Raija. 2010. Microvillus - a hyaluronan synthesizing organelle. Trends in Cell & Molecular Biology 5: 1-8. 2010
• Viiri J, Hyttinen JMT, Ryhänen T, Rilla K, Paimela T, Kuusisto E, Siitonen A, Urtti A, Salminen A & Kaarniranta K. 2010. p62/sequestosome 1 as a regulator of proteasome inhibitor-induced autophagy in human retinal pigment epithelial cells. MOLECULAR VISION [ONLINE: HTTP://WWW.MOLVIS.ORG/MOLVIS/] 16: 1399-1414. 2010
• Kultti A, Pasonen-Seppänen S, Jauhiainen Marjo, Rilla KJ, Kärnä R, Pyöriä E, Tammi RH, Tammi MI. 2009. 4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3. EXPERIMENTAL CELL RESEARCH 315: 1914-1923. 2009
• Nykopp TK, Rilla K, Sironen R, Tammi MI, Tammi RH, Hämäläinen K, Heikkinen A-M, Komulainen M, Kosma V-M, Anttila M. 2009. Expression of hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in serous ovarian carcinomas: inverse correlation between HYALI and hyaluronan content. BMC CANCER [ONLINE: HTTP://WWW.BIOMEDCENTRAL.COM/BMCCANCER/] 9 143: [9 p.]. 2009
• Törrönen K, Rilla K. 2008. Solunetti - biotieteitä verkossa (www.solunetti.fi). SOLUBIOLOGI 26 1: 16-19. 2008
• Jokela TA, Lindgren A, Rilla K, Maytin E, Hascall VC, Tammi RH, Tammi MI. 2008. Induction of hyaluronan cables and monocyte adherence in epidermal keratinocytes. CONNECTIVE TISSUE RESEARCH 49: 115-119. 2008
• Rilla K, Tiihonen R, Kultti A, Tammi M, Tammi R. 2008. Pericellular hyaluronan coat visualized in live cells with a fluorescent probe is scaffolded by plasma membrane protrusions. JOURNAL OF HISTOCHEMISTRY AND CYTOCHEMISTRY 56 10: 901-910. 2008
• Rilla K. 2006. Hyaluronan Synthase. Intracellular Traffic, Activity at Plasma Membrane, and Impact on Keratinocyte Micration, Proliferation and Formation of Microvilli. Kuopio University Publications D. Medical Sciences. 2006
• Kultti A, Rilla K, Tiihonen R, Spicer AP, Tammi R, Tammi M. 2006. Hyaluronan synthesis induces microvillus-like cell surface protrusions. JOURNAL OF BIOLOGICAL CHEMISTRY 281 23: 15821-15828. 2006
• Rilla K, Tammi R. 2005. Iho tarvitsee hyaluronaania. SOLUBIOLOGI 23 2: 10-15. 2005
• Tammi M, Törrönen K, Pasonen-Seppänen S, Karvinen S, Rilla K, Pienimäki J-P, Tammi R. 2005. Hyaluronan and CD44 in epidermal activation: Balazs EA, Hascall VC, Hyaluronan Structure, Metabolism, Biological Activities, Therapeutic Applications. Hyaluronan 2003..Matrix Biology Institute. 641-647. 2005
• Törrönen K, Rilla K, Tammi R, Tammi M. 2005. Hyaluronan size dependent migration and mitogen activated protein kinase signalling in human keratinocytes: Balazs EA, Hascall VC, Hyaluronan Structure, Metabolism, Biological Activities, Therapeutic Applications.Matrix Biology Institute. 649-653. 2005
• Rilla K, Siiskonen H, Spicer AP, Hyttinen JMT, Tammi MI, Tammi RH. 2005. Plasma membrane residence of hyaluronan synthase is coupled to its entzymatic activity. JOURNAL OF BIOLOGICAL CHEMISTRY 280 36: 31890-31897. 2005
• Rilla K, Hyttinen JMT, Törrönen K, Pasonen-Seppänen S, Heldin P, Spicer AP, Rieppo J, Mättö M, Tammi M, Tammi R. 2005. Suppression of hyaluronan synthesis by 4-methylumbelliferone retards keratinocyte migration and proliferation: Balazs EA, Hascall VC, Hyaluronan Structure, Metabolism, Biological Activities, Therapeutic Applications. Hyaluronan 2003..Matrix Biology Institute. 637-640. 2005
• Kultti A, Rilla K, Törrönen K, MacDonald J, Tammi R, Tammi M. 2005. 4-methylumbelliferone inhibits hyaluronan synthesis, proliferation and migration by suppressing hyaluronan synthase 2 and 3 messenger RNA levels in breast cancer cells: Balazs EA, Hascall VC, Hyaluronan Structure, Metabolism, Biological Activities, Therapeutic Applications. Hyaluronan 2003.Matrix Biology Institute. 283-287. 2005
• Rilla K, Pasonen-Seppänen S, Rieppo J, Tammi M, Tammi R. 2004. The hyaluronan synthesis inhibitor 4-methylumbelliferone prevents keratinocyte activation and epidermal hyperproliferation induced by epidermal growth factor. JOURNAL OF INVESTIGATIVE DERMATOLOGY 123: 708-714. 2004
• Rilla K, Lammi M, Sironen R, Hascall VC, Midura R, Tammi M, Tammi R. 2002. Hyaluronan synthase 2 (HAS2) regulates migration of epidermal keratinocytes: Kennedy JF, Phillips GO, Williams PA, Hascall VC, Hyaluronan. Chemical, Biochemical and Biological Aspects.Woodhead. 557-560. 2002
• Rilla K, Lammi MJ, Sironen R, Törrönen K, Luukkonen M, Hascall VC, Midura RJ, Hyttinen M, Pelkonen J, Tammi M, Tammi R. 2002. Changed lamellipodial extension, adhesion plaques and migration in epidermal keratinocytes containing constitutively expressed sense and antisense hyaluronan synthase 2 (Has2) genes JOURNAL OF CELL SCIENCE 115: 3633-3643. 2002
• Tammi MI, Pienimäki J-P, Rilla K, Fülöp C, Lammi MJ, Sironen R, Midura R, Hascall VC, Luukkonen M, Törrönen K, Lehto T, Tammi R. 2002. EGF regulates HAS2 expression, controls epidermal thickness and stimulates keratinocyte migration: Kennedy JF, Phillips GO, Williams PA, Hascall VC, Hyaluronan. Chemical, Biochemical and Biological Aspects..Woodhead. 561-570. 2002
• Tammi R, Rilla K, Pienimäki J-P, Hogg M, MacCallum DK, Hascall VC, Tammi M. 2002. Intracellular hyaluronan in epidermal keratinocytes: Kennedy JF, Phillips GO, Williams PA, Hascall VC, Hyaluronan. Chemical, Biochemical and Biological Aspects.Woodhead. 517-524. 2002
• Törrönen K, Yabal M, Rilla K, Kaarniranta K, Tammi R, Lammi MJ, Tammi M. 2002. Hyaluronan stimulates keratinocyte migration and activates the transcription factor AP-1 in keratinocytes through the JNK pathway. Teoksessa: Kennedy JF, Phillips GO, Williams PA, Hascall VC (toim.), Hyaluronan. Chemical, Biochemical and Biological Aspects..Woodhead. ss. 551-556. 2002
• Pienimäki J-P, Rilla K, Csaba F, Sironen RK, Karvinen S, Pasonen S, Lammi MJ, Tammi R, Hascall VC, Tammi MI. 2001. Epidermal growth factor activates hyaluronan synthase 2 in epidermal keratinocytes and increases pericellular and intracellular hyaluronan. JOURNAL OF BIOLOGICAL CHEMISTRY 276 23: 20428-20435. 2001
• Tammi R, Rilla K, Pienimäki J-P, MacCallum DK, Hogg M, Luukkonen M, Hascall VC, Tammi M. 2001. Hyaluronan enters keratinocytes by a novel endocytic route for catabolism. JOURNAL OF BIOLOGICAL CHEMISTRY 276 37: 35111-35122. 2001