Kirsi Rilla

Ahmad, Aqeel; Rilla, Kirsi; Zou, Jing; Zhang, Weikai; Pyykkö, Ilmari; Kinnunen, Paavo; Ranjan, Sanjeev. 2021. Enhanced gene expression by a novel designed leucine zipper endosomolytic peptide International journal of pharmaceutics 601: 120556. 2021

Singh, Sima; Numan, Arshid; Somaily, Hamoud H.; Gorain, Bapi; Ranjan, Sanjeev; Rilla, Kirsi; Siddique, Hifzur R.; Kesharwani, Prashant. 2021. Nano-enabled strategies to combat methicillin-resistant Staphylococcus aureus Materials science and engineering c: materials for biological applications 129: 112384. 2021

Verweij, FJ; Balaj, L; Boulanger, CM; Carter, DR; Compeer, EB; D'Angelo, G; El Andaloussi, S; Goetz, JG; Gross, JC; Hyenne, V; Krämer-Albers, EM; Lai, CP; Loyer, X; Marki, A; Momma, S; Nolte-'t Hoen, ENM; Pegtel, DM; Peinado, H; Raposo, G; Rilla, K; Tahara, H; Théry, C; van Royen, ME; Vandenbroucke, RE; Wehman, AM; Witwer, K; Wu, Z; Wubbolts, R; van Niel, G. 2021. The power of imaging to understand extracellular vesicle biology in vivo Nature methods 18 9: 1013-1026. 2021

Mustonen, Anne-Mari; Capra, Janne; Rilla, Kirsi; Lehenkari, Petri; Oikari, Sanna; Kääriäinen, Tommi; Joukainen, Antti; Kröger, Heikki; Paakkonen, Tommi; Matilainen, Johanna; Nieminen, Petteri. 2021. Characterization of hyaluronan-coated extracellular vesicles in synovial fluid of patients with osteoarthritis and rheumatoid Bmc musculoskeletal disorders 22 1: 247. 2021

Rilla, Kirsi. 2021. Diverse plasma membrane protrusions act as platforms for extracellular vesicle shedding Journal of extracellular vesicles 10 11: e12148. 2021

Numan, Arshid; Singh, Sima; Zhan, Yiqiang; Li, Lijie; Khalid, Mohammad; Rilla, Kirsi; Ranjan, Sanjeev; Cinti, Stefano. 2021. Advanced nanoengineered - customized point-of-care tools for prostate-specific antigen Microchimica acta 189 1: 27. 2021

Aaltonen, Niina; Singha, Prosanta; Jakupovic, Hermina; Wirth, Thomas; Samaranayake, Haritha; Pasonen-Seppänen, Sanna; Rilla, Kirsi; Varjosalo, Markku; Edgington-Mitchell, Laura; Kasperkiewicz, Paulina; Drag, Marcin; Kälvälä, Sara; Moisio, Eemeli; Savinainen, Juha; Laitinen, Jarmo. 2020. High-Resolution Confocal Fluorescence Imaging of Serine Hydrolase Activity in Cryosections - Application to Glioma Brain Unveils Activity Hotspots Originating from Tumor-Associated Neutrophils Biological procedures online 22: 6. 2020

Kyykallio, Heikki; Oikari, Sanna; Álvez, María Bueno; Dodd, Carlos José Gallardo; Capra, Janne; Rilla, Kirsi. 2020. The density and length of filopodia associate with the activity of hyaluronan synthesis in tumor cells Cancers 12 7: 1908. 2020

Marttinen, Mikael; Ferreira, Catarina B; Paldanius, Kaisa M A; Takalo, Mari; Natunen, Teemu; Mäkinen, Petra; Leppänen, Luukas; Leinonen, Ville; Tanigaki, Kenji; Kang, Gina; Hiroi, Noboru; Soininen, Hilkka; Rilla, Kirsi; Haapasalo, Annakaisa; Hiltunen, Mikko. 2020. Presynaptic Vesicle Protein SEPTIN5 Regulates the Degradation of APP C-Terminal Fragments and the Levels of Aß Cells 9 11: 2482. 2020

Matilainen, Johanna; Mustonen, Anne-Mari; Rilla, Kirsi; Käkelä, Reijo; Sihvo, Sanna; Nieminen, Petteri. 2020. Orotic acid-treated hepatocellular carcinoma cells resist steatosis by modification of fatty acid metabolism Lipids in health and disease 19 1: 70. 2020

Tiainen, Satu; Rilla, Kirsi; Hämäläinen, Kirsi; Oikari, Sanna; Auvinen, Päivi. 2020. The prognostic and predictive role of the neutrophil-to-lymphocyte ratio and the monocyte-to-lymphocyte ratio in early breast cancer, especially in the HER2+ subtype Breast cancer research and treatment 2021; 185: 63-72. 2020

Arasu, Uma Thanigai; Härkönen, Kai; Koistinen, Arto; Rilla, Kirsi. 2019. Correlative light and electron microscopy is a powerful tool to study interactions of extracellular vesicles with recipient cells Experimental cell research 376 2: 149-158. 2019

Arasu, UT; Deen, AJ; Pasonen-Seppänen, S; Heikkinen, S; Lalowski, M; Kärnä, R; Härkönen, K; Mäkinen, P; Lázaro-Ibáñez, E; Siljander, PR; Oikari, S; Levonen, AL; Rilla, K. 2019. HAS3-induced extracellular vesicles from melanoma cells stimulate IHH mediated c-Myc upregulation via the hedgehog signaling pathway in target cells Cellular and molecular life sciences [Published: 09 December 2019]: 1-23. 2019

Hellinen, Laura; Sato, Kazuki; Reinisalo, Mika; Kidron, Heidi; Rilla, Kirsi; Tachikawa, Masanori; Uchida, Yasuo; Terasaki, Tetsuya; Urtti, Arto. 2019. Quantitative Protein Expression in the Human Retinal Pigment Epithelium: Comparison Between Apical and Basolateral Plasma Membranes With Emphasis on Transporters Investigative ophthalmology and visual science 60 15: 5022-5034. 2019

Härkönen, K; Oikari, S; Kyykallio, H; Capra, J; Hakkola, S; Ketola, K; Thanigai Arasu, U; Daaboul, G; Malloy, A; Oliveira, C; Jokelainen, O; Sironen, R; Hartikainen, JM; Rilla, K. 2019. CD44s Assembles Hyaluronan Coat on Filopodia and Extracellular Vesicles and Induces Tumorigenicity of MKN74 Gastric Carcinoma Cells Cells 8 3: 276. 2019

Melero-Fernandez de Mera, RM; Arasu, UT; Kärnä, R; Oikari, S; Rilla, K; Vigetti, D; Passi, A; Heldin, P; Tammi, MI; Deen, AJ. 2019. Effects of mutations in the post-translational modification sites on the trafficking of hyaluronan synthase 2 (HAS2) Matrix biology 80: 85-103. 2019

Mustonen, Anne-Mari; Salvén, Anu; Kärjä, Vesa; Rilla, Kirsi; Matilainen, Johanna; Nieminen, Petteri. 2019. Hyaluronan histochemistry - A potential new tool to assess the progress of liver disease from simple steatosis to hepatocellular carcinoma Glycobiology 29 4: 298-306. 2019

Rilla, Kirsi; Mustonen, Anne-Mari; Thanigai, Arasu Uma; Härkönen, Kai; Matilainen, Johanna; Nieminen, Petteri. 2019. Extracellular vesicles are integral and functional components of the extracellular matrix Matrix biology 75-76: 201-219. 2019

Tammi, Markku I; Oikari, Sanna; Pasonen-Seppänen, Sanna; Rilla, Kirsi; Auvinen, Päivi; Tammi, Raija H. 2019. Activated hyaluronan metabolism in the tumor matrix - Causes and consequences Matrix biology 78-79: 147-164. 2019

Tiainen, S; Masarwah, A; Oikari, S; Rilla, K; Hämäläinen, K; Sudah, M; Sutela, A; Vanninen, R; Ikonen, J; Tammi, R; Tammi, M; Auvinen, P. 2019. Tumor microenvironment and breast cancer survival: combined effects of breast fat, M2 macrophages and hyaluronan create a dismal prognosis Breast cancer research and treatment 2020; 179: 565-575. 2019

Valkonen, Mari; Haapasalo, Hannu; Rilla, Kirsi; Tyynelä-Korhonen, Kristiina; Soini, Ylermi; Pasonen-Seppänen, Sanna. 2018. Elevated expression of hyaluronan synthase 2 associates with decreased survival in diffusely infiltrating astrocytomas Bmc cancer 18 1: 664. 2018

Karttunen, Jenni; Heiskanen, Mette; Navarro-Ferrandis, Vicente; Das Gupta, Shalini; Lipponen, Anssi; Puhakka, Noora; Rilla, Kirsi; Koistinen, Arto; Pitkänen, Asla. 2018. Precipitation-based extracellular vesicle isolation from rat plasma co-precipitate vesicle-free microRNAs Journal of Extracellular Vesicles 2019; 8 1: 1555410. 2018

Koistinen Ville, Härkönen Kai, Kärnä Riikka, Arasu Uma Thanigi, OIkari Sanna, Rilla Kirsi. 2017. EMT induced by EGF and wounding activates hyaluronan synthesis machinery and EV shedding in rat primary mesothelial cells. MATRIX BIOLOGY 63: 38-54. 2017

Lazaro-Ibanez Elisa, Neuvonen Maarit, Takatalo Maarit, Arasu Uma Thanigai, Capasso Cristian, Cerullo Vincenzo, Rhim Johng S, Rilla Kirsi, Yliperttula Marjo, Siljander Pia R -M. 2017. Metastatic state of parent cells influences the uptake and functionality of prostate cancer cell-derived extracellular vesicles. Journal of Extracellular Vesicles 6 1: 1354645. 2017

Martiskainen H, Paldanius KMA, Natunen T, Takalo M, Marttinen M, Leskelä S, Huber N, Mäkinen P, Bertling E, Dhungana H, Huuskonen M, Honkakoski P, Hotulainen P, Rilla K, Koistinaho J, Soininen H, Malm T, Haapasalo A, Hiltunen M. 2017. DHCR24 exerts neuroprotection upon inflammation-induced neuronal death. JOURNAL OF NEUROINFLAMMATION [HTTP://WWW.JNEUROINFLAMMATION.COM/] 14: 215. 2017

Pesonen M, Rysä J, Storvik M, Rilla K, Pasanen M, Vähäkangas K. 2017. Molecular targets of chloropicrin in human airway epithelial cells. TOXICOLOGY IN VITRO 42: 247-254. 2017

Arasu UT, Kärnä R, Härkönen K, Oikari S, Koistinen A, Kröger H, Qu C, Lammi MJ, Rilla K. 2017. Human mesenchymal stem cells secrete hyaluronan-coated extracellular vesicles. MATRIX BIOLOGY 64: 54-68. 2017

Rilla Kirsi, Hiltunen Mikko. 2016. Ekstrasellulaarivesikkelit tulevaisuuden biomarkkereina. BestPractice Psykiatria/neurologia: lääketieteen asiantuntijoiden ammattilehti 4 16 (Lokakuu 2016): 11-13. 2016

Törrönen Kari, Soini Ylermi, Pääkkö Paavo, Parkkinen Jyrki, Sironen Reijo, Rilla Kirsi. 2016. Mesotheliomas show higher hyaluronan positivity around tumor cells than metastatic pulmonary adenocarcinomas. HISTOLOGY AND HISTOPATHOLOGY 31 10: 1113-1122. 2016

Tiainen Satu, Oikari Sanna, Tammi Markku, Rilla Kirsi, Hämäläinen Kirsi, Tammi Raija, Kosma Veli-Matti, Auvinen Päivi. 2016. High extent of O-GlcNAcylation in breast cancer cells correlates with the levels of HAS enzymes, accumulation of hyaluronan, and poor outcome. BREAST CANCER RESEARCH AND TREATMENT 160 2: 237-247. 2016

Mustonen A-M, Nieminen P, Joukainen A, Jaroma A, Kääriäinen T, Kröger H, Lázaro-Ibáñez E, Siljander PR-M, Kärjä V, Härkönen K, Koistinen A, Rilla K. 2016. First in vivo detection and characterization of hyaluronan-coated extracellular vesicles in human synovial fluid. JOURNAL OF ORTHOPAEDIC RESEARCH 34 11: 1960-1968. 2016

Koistinen Ville, Jokela Tiina, Oikari Sanna, Kärnä Riikka, Tammi Markku, Rilla Kirsi. 2016. Hyaluronan-positive plasma membrane protrusions exist on mesothelial cells in vivo. HISTOCHEMISTRY AND CELL BIOLOGY 145 5: 531-544. 2016

Deen AJ, Arasu UT, Pasonen-Seppänen S, Hassinen A, Takabe P, Wojciechowski S, Kärnä R, Rilla K, Kellokumpu S, Tammi R, Tammi M, Oikari S. 2016. UDP-sugar substrates of HAS3 regulate its O-GlcNAcylation, intracellular traffic, extracellular shedding and correlate with melanoma progression. CELLULAR AND MOLECULAR LIFE SCIENCES: CMLS 73 16: 3183-3204. 2016

Jokela Tiina, Oikari Sanna, Takabe Piia, Rilla Kirsi, Kärnä Riikka, Tammi Markku, Tammi Raija. 2015. Interleukin-1ß-induced Reduction of CD44 Ser-325 Phosphorylation in Human Epidermal Keratinocytes Promotes CD44 Homomeric Complexes, Binding to Ezrin, and Extended, Monocyte-adhesive Hyaluronan Coats. JOURNAL OF BIOLOGICAL CHEMISTRY 290: 12379-12393. 2015

Koistinen Ville, Kärnä Riikka, Koistinen Arto, Arjonen Antti, Tammi Markku, Rilla Kirsi. 2015. Cell protrusions induced by hyaluronan synthase 3 (HAS3) resemble mesothelial microvilli and share cytoskeletal features of filopodia. EXPERIMENTAL CELL RESEARCH 337 2: 179-191. 2015

Rilla Kirsi, Koistinen Arto. 2015. Correlative Light and Electron Microscopy Reveals the HAS3-Induced Dorsal Plasma Membrane Ruffles. International Journal of Cell Biology 2015 Article ID 769163: 8 pages. 2015

Siiskonen Hanna, Oikari Sanna, Pasonen-Seppänen Sanna, Rilla Kirsi. 2015. Hyaluronan synthase 1: a mysterious enzyme with unexpected functions. Frontiers in immunology epub. 2015

Sokka Miiko, Rilla Kirsi, Miinalainen Ilkka, Pospiech Helmut, Syväoja Juhani E.. 2015. High levels of TopBP1 induce ATR-dependent shut-down of rRNA transcription and nucleolar segregation. NUCLEIC ACIDS RESEARCH 43 10: 4975-4989. 2015

Takabe Piia, Bart Genevieve, Ropponen Antti, Rilla Kirsi, Tammi Markku, Tammi Raija, Pasonen-Seppanen Sanna. 2015. Hyaluronan synthase 3 (HAS3) overexpression downregulates MV3 melanoma cell proliferation, migration and adhesion. EXPERIMENTAL CELL RESEARCH 337 1: 1-15. 2015

Tiainen Satu, Tumelius Ritva, Rilla Kirsi, Hämäläinen Kirsi, Tammi Markku, Tammi Raija, Kosma Veli-Matti, Oikari Sanna, Auvinen Päivi. 2014. High numbers of macrophages, especially M2-like (CD163-positive), correlate with hyaluronan accumulation and poor outcome in breast cancer. HISTOPATHOLOGY 2014; 66 6: 873-883. 2014

Rilla Kirsi, Siiskonen Hanna, Tammi Markku, Tammi Raija. 2014. Hyaluronan-coated extracellular vesicles - a novel link between hyaluronan and cancer. Advances in cancer research 123: 121-148. 2014

Qu C, Rilla K, Tammi R, Tammi M, Kröger H, Lammi MJ. 2014. Extensive CD44-dependent hyaluronan coats on human bone marrow-derived mesenchymal stem cells produced by hyaluronan synthases HAS1, HAS2 and HAS3. INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND CELL BIOLOGY 48: 45-54. 2014

Rilla K, Koistinen AP. 2014. Correlative light and electron microscopy reveals the morphological changes of HAS3 overexpressing breast cancer cells and their hyaluronan-dependent plasma membrane protrusions: Linköping University, 65th Annual Conference of the Nordic Microscopy Society, Scandem 2014. http://www.trippus.se/eventus/userfiles/51916.pdf. 2014

Pesonen Maija, Häkkinen Merja, Rilla Kirsi, Juvonen Risto, Kuitunen Tapio, Pasanen Markku, Vähäkangas Kirsi. 2014. Chloropicrin-induced toxic responses in human lung epithelial cells. TOXICOLOGY LETTERS 226: 236-244. 2014

Deen Ashik Jawahar, Rilla Kirsi, Oikari Sanna, Kärnä Riikka, Bart Genevieve, Häyrinen Jukka, Bathina Avinash Rahul, Ropponen Antti, Makkonen Katri, Tammi Raija H, Tammi Markku I. 2014. Rab10-mediated endocytosis of the hyaluronan synthase HAS3 regulates hyaluronan synthesis and cell adhesion to collagen. JOURNAL OF BIOLOGICAL CHEMISTRY 289 12: 8375-89. 2014

Auvinen Päivi, Rilla Kirsi, Tumelius Ritva, Tammi Markku, Sironen Reijo, Soini Ylermi, Kosma Veli-Matti, Mannermaa Arto, Viikari Jukka, Tammi Raija. 2014. Hyaluronan synthases (HAS1-3) in stromal and malignant cells correlate with breast cancer grade and predict patient survival. BREAST CANCER RESEARCH AND TREATMENT 143 2: 277-286. 2014

Karjalainen Hannu M, Qu Chengjuan, Leskelä Stina S, Rilla Kirsi, Lammi Mikko J. 2014. Chondrocytic cells express the taurine transporter on their plasma membrane and regulate its expression under anisotonic conditions. AMINO ACIDS 47 3: 561-570. 2014

Siiskonen H, Kärnä R, Hyttinen JM, Tammi RH, Tammi MI, Rilla K. 2013. Hyaluronan synthase 1 (HAS1) produces a cytokine- and glucose-inducible, CD44-dependent cell surface coat. EXPERIMENTAL CELL RESEARCH online: -. 2013

Viiri J, Amadio M, Marchesi N, Hyttinen JM, Kivinen N, Sironen R, Rilla K, Akhtar S, Provenzani A, D'Agostino VG, Govoni S, Pascale A, Agostini H, Petrovski G, Salminen A, Kaarniranta K. 2013. Autophagy Activation Clears ELAVL1/HuR-Mediated Accumulation of SQSTM1/p62 during Proteasomal Inhibition in Human Retinal Pigment Epithelial Cells. PLOS ONE [ONLINE] 8 7: e6963, 16 pages. 2013

Törrönen K, Nikunen K, Kärnä R, Tammi M, Tammi R, Rilla K. 2013. Tissue distribution and subcellular localization of hyaluronan synthase isoenzymes. HISTOCHEMISTRY AND CELL BIOLOGY 140 13: -. 2013

Tuuminen R, Nykänen AI, Saharinen P, Gautam P, Keränen MA, Arnaudova R, Rouvinen E, Helin H, Tammi R, Rilla K, Krebs R, Lemström KB. 2013. Donor simvastatin treatment prevents ischemia-reperfusion and acute kidney injury by preserving microvascular barrier function. American Journal of Transplantation 13 8: 2019-34. 2013

Rilla K, Pasonen-Seppänen S, Deen AJ, Koistinen VVT, Wojciechowski S, Oikari S, Kärnä R, Bart G, Törrönen K, Tammi RH, Tammi MI. 2013. Hyaluronan production enhances shedding of plasma membrane-derived microvesicles. EXPERIMENTAL CELL RESEARCH 319 13: 2006-2018. 2013

Rilla K, Oikari S, Jokela TA, Hyttinen JMT, Kärnä R, Tammi RH, Tammi MI. 2013. Hyaluronan synthase 1 (HAS1) requires higher cellular UDP-GIcNAc concentration than HAS2 and HAS3. JOURNAL OF BIOLOGICAL CHEMISTRY 288 8: 5973-5983. 2013

Jokela TA, Kuokkanen J, Kärnä R, Pasonen-Seppänen S, Rilla K, Kössi J, Laato M, Tammi RH, Tammi MI. 2013. Mannose reduces hyaluronan and leukocytes in wound granulation tissue and inhibits migration and hyaluronan-dependent monocyte binding. Wound Repair and Regeneration 21: 247-255. 2013

Högnäs G, Hämälistö S, Rilla K, Laine JO, Vilkki V, Murumägi A, Edgren H, Kallioniemi O, Ivaska J. 2013. Aneuploidy facilitates oncogenic transformation via specific genetic alterations, including Twist2 upregulation. CARCINOGENESIS Epub: e1-10. 2013

Hakkarainen Jenni J, Rilla Kirsi, Suhonen Marjukka, Ruponen Marika, Forsberg Markus M. 2013. Re-evaluation of the role of P-glycoprotein in in vitro drug permeability studies with the bovine brain microvessel endothelial cells. XENOBIOTICA (LONDON) 2014:44: 283-294. 2013

Pasonen-Seppänen S, Hyttinen JM, Rilla K, Jokela T, Noble PW, Tammi M, Tammi R. 2012. Role of CD44 in the organization of keratinocyte pericellular hyaluronan HISTOCHEMISTRY AND CELL BIOLOGY 137: 107-120. 2012

Pasonen-Seppänen S, Takabe P, Edward M, Rauhala L, Rilla K, Tammi M, Tammi R. 2012. Melanoma cell-derived factors stimulate hyaluronan in dermal fibroblasts by upregulating HAS2 through PDGFR-PI3K_AKT and p38 -signaling. HISTOCHEMISTRY AND CELL BIOLOGY 138 6: 895-911. 2012

Siiskonen H, Rilla K, Kärnä R, Bart G, Jing W, Haller MF, DeAngelis PL, Tammi RH, Tammi MI. 2012. Hyaluronan in cytosol - microinjection-based probing of its existence and suggested functions. GLYCOBIOLOGY online: -. 2012

Xu Wujun, Riikonen Joakim, Nissinen Tuomo, Suvanto Mika, Rilla Kirsi, Li Bojie, Wang Qiang, Deng Feng, Lehto Vesa-Pekka. 2012. Amine Surface Modifications and Fluorescent Labeling of Thermally Stabilized Mesoporous Silicon Nanoparticles. JOURNAL OF PHYSICAL CHEMISTRY. C 116 42: 22307-22314. 2012

Rilla Kirsi, Pasonen-Seppänen Sanna, Kärnä Riikka, Karjalainen Hannu M, Törrönen Kari, Koistinen Ville, Tammi Markku I, Tammi Raija H, Teräväinen Terhi, Manninen Aki. 2011. HAS3-induced accumulation of hyaluronan in 3D MDCK cultures results in mitotic spindle misorientation and disturbed organization of epithelium HISTOCHEMISTRY AND CELL BIOLOGY 137 2: 153-164. 2011

Siiskonen Hanna, Törrönen Kari, Kumlin Timo, Rilla Kirsi, Tammi Markku I, Tammi Raija H. 2011. Chronic UVR Causes Increased Immunostaining of CD44 and Accumulation of Hyaluronan in Mouse Epidermis JOURNAL OF HISTOCHEMISTRY AND CYTOCHEMISTRY 59 10: 908-917. 2011

Tammi Raija H, Passi Alberto G, Rilla Kirsi, Karousou Evgenia, Vigetti Davide, Makkonen Katri, Tammi Markku I. 2011. Transcriptional and post-translational regulation of hyaluronan synthesis. FEBS JOURNAL 278 9: 1- 10. 2011

Viiri J, Hyttinen JMT, Ryhänen T, Rilla K, Paimela T, Kuusisto E, Siitonen A, Urtti A, Salminen A & Kaarniranta K. 2010. p62/sequestosome 1 as a regulator of proteasome inhibitor-induced autophagy in human retinal pigment epithelial cells. MOLECULAR VISION [ONLINE: HTTP://WWW.MOLVIS.ORG/MOLVIS/] 16: 1399-1414. 2010

Rilla Kirsi, Tammi Markku, Tammi Raija. 2010. Microvillus - a hyaluronan synthesizing organelle. Trends in Cell & Molecular Biology 5: 1-8. 2010

Rilla K, Tammi M & Tammi R. 2010. The enigma of hyaluronan-synthesizing membrane protrusions and hyaluronan coats. GlycoForum HA35: 1-10. 2010

Nykopp TK, Rilla K, Tammi MI, Tammi RH, Sironen R, Hämäläinen K, Kosma V-M, Heinonen S & Anttila M. 2010. Hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma BMC CANCER 10: 512. 2010

Kultti A, Kärnä R, Rilla K, Nurminen P, Koli E, Makkonen KM, Si J, Tammi MI & Tammi R. 2010. Methyl-β-cyclodetextrin suppresses hyaluronan synthesis by down-regulation of hyaluronan synthase 2 through inhibition of Akt. JOURNAL OF BIOLOGICAL CHEMISTRY 285 30: 22901-22910. 2010

Kultti A, Pasonen-Seppänen S, Jauhiainen Marjo, Rilla KJ, Kärnä R, Pyöriä E, Tammi RH, Tammi MI. 2009. 4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3. EXPERIMENTAL CELL RESEARCH 315: 1914-1923. 2009

Nykopp TK, Rilla K, Sironen R, Tammi MI, Tammi RH, Hämäläinen K, Heikkinen A-M, Komulainen M, Kosma V-M, Anttila M. 2009. Expression of hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in serous ovarian carcinomas: inverse correlation between HYALI and hyaluronan content. BMC CANCER [ONLINE: HTTP://WWW.BIOMEDCENTRAL.COM/BMCCANCER/] 9 143: [9 p.]. 2009

Jokela TA, Lindgren A, Rilla K, Maytin E, Hascall VC, Tammi RH, Tammi MI. 2008. Induction of hyaluronan cables and monocyte adherence in epidermal keratinocytes Connective tissue research 49: 115-119. 2008

Rilla K, Tiihonen R, Kultti A, Tammi M, Tammi R. 2008. Pericellular hyaluronan coat visualized in live cells with a fluorescent probe is scaffolded by plasma membrane protrusions. JOURNAL OF HISTOCHEMISTRY AND CYTOCHEMISTRY 56 10: 901-910. 2008

Törrönen K, Rilla K. 2008. Solunetti - biotieteitä verkossa (www.solunetti.fi). SOLUBIOLOGI 26 1: 16-19. 2008

Kultti A, Rilla K, Tiihonen R, Spicer AP, Tammi R, Tammi M. 2006. Hyaluronan synthesis induces microvillus-like cell surface protrusions. JOURNAL OF BIOLOGICAL CHEMISTRY 281 23: 15821-15828. 2006

Rilla K. 2006. Hyaluronan Synthase. Intracellular Traffic, Activity at Plasma Membrane, and Impact on Keratinocyte Micration, Proliferation and Formation of Microvilli. Kuopio University Publications D. Medical Sciences. 2006

Törrönen K, Rilla K, Tammi R, Tammi M. 2005. Hyaluronan size dependent migration and mitogen activated protein kinase signalling in human keratinocytes: Balazs EA, Hascall VC, Hyaluronan Structure, Metabolism, Biological Activities, Therapeutic Applications.Matrix Biology Institute. 649-653. 2005

Tammi M, Törrönen K, Pasonen-Seppänen S, Karvinen S, Rilla K, Pienimäki J-P, Tammi R. 2005. Hyaluronan and CD44 in epidermal activation: Balazs EA, Hascall VC, Hyaluronan Structure, Metabolism, Biological Activities, Therapeutic Applications. Hyaluronan 2003..Matrix Biology Institute. 641-647. 2005

Rilla K, Siiskonen H, Spicer AP, Hyttinen JMT, Tammi MI, Tammi RH. 2005. Plasma membrane residence of hyaluronan synthase is coupled to its entzymatic activity. JOURNAL OF BIOLOGICAL CHEMISTRY 280 36: 31890-31897. 2005

Rilla K, Tammi R. 2005. Iho tarvitsee hyaluronaania. SOLUBIOLOGI 23 2: 10-15. 2005

Rilla K, Hyttinen JMT, Törrönen K, Pasonen-Seppänen S, Heldin P, Spicer AP, Rieppo J, Mättö M, Tammi M, Tammi R. 2005. Suppression of hyaluronan synthesis by 4-methylumbelliferone retards keratinocyte migration and proliferation: Balazs EA, Hascall VC, Hyaluronan Structure, Metabolism, Biological Activities, Therapeutic Applications. Hyaluronan 2003..Matrix Biology Institute. 637-640. 2005

Kultti A, Rilla K, Törrönen K, MacDonald J, Tammi R, Tammi M. 2005. 4-methylumbelliferone inhibits hyaluronan synthesis, proliferation and migration by suppressing hyaluronan synthase 2 and 3 messenger RNA levels in breast cancer cells: Balazs EA, Hascall VC, Hyaluronan Structure, Metabolism, Biological Activities, Therapeutic Applications. Hyaluronan 2003.Matrix Biology Institute. 283-287. 2005

Rilla K, Pasonen-Seppänen S, Rieppo J, Tammi M, Tammi R. 2004. The hyaluronan synthesis inhibitor 4-methylumbelliferone prevents keratinocyte activation and epidermal hyperproliferation induced by epidermal growth factor. JOURNAL OF INVESTIGATIVE DERMATOLOGY 123: 708-714. 2004

Rilla K, Lammi M, Sironen R, Hascall VC, Midura R, Tammi M, Tammi R. 2002. Hyaluronan synthase 2 (HAS2) regulates migration of epidermal keratinocytes: Kennedy JF, Phillips GO, Williams PA, Hascall VC, Hyaluronan. Chemical, Biochemical and Biological Aspects.Woodhead. 557-560. 2002

Rilla K, Lammi MJ, Sironen R, Törrönen K, Luukkonen M, Hascall VC, Midura RJ, Hyttinen M, Pelkonen J, Tammi M, Tammi R. 2002. Changed lamellipodial extension, adhesion plaques and migration in epidermal keratinocytes containing constitutively expressed sense and antisense hyaluronan synthase 2 (Has2) genes JOURNAL OF CELL SCIENCE 115: 3633-3643. 2002

Tammi MI, Pienimäki J-P, Rilla K, Fülöp C, Lammi MJ, Sironen R, Midura R, Hascall VC, Luukkonen M, Törrönen K, Lehto T, Tammi R. 2002. EGF regulates HAS2 expression, controls epidermal thickness and stimulates keratinocyte migration: Kennedy JF, Phillips GO, Williams PA, Hascall VC, Hyaluronan. Chemical, Biochemical and Biological Aspects..Woodhead. 561-570. 2002

Tammi R, Rilla K, Pienimäki J-P, Hogg M, MacCallum DK, Hascall VC, Tammi M. 2002. Intracellular hyaluronan in epidermal keratinocytes: Kennedy JF, Phillips GO, Williams PA, Hascall VC, Hyaluronan. Chemical, Biochemical and Biological Aspects.Woodhead. 517-524. 2002

Törrönen K, Yabal M, Rilla K, Kaarniranta K, Tammi R, Lammi MJ, Tammi M. 2002. Hyaluronan stimulates keratinocyte migration and activates the transcription factor AP-1 in keratinocytes through the JNK pathway. Teoksessa: Kennedy JF, Phillips GO, Williams PA, Hascall VC (toim.), Hyaluronan. Chemical, Biochemical and Biological Aspects..Woodhead. ss. 551-556. 2002

Pienimäki J-P, Rilla K, Csaba F, Sironen RK, Karvinen S, Pasonen S, Lammi MJ, Tammi R, Hascall VC, Tammi MI. 2001. Epidermal growth factor activates hyaluronan synthase 2 in epidermal keratinocytes and increases pericellular and intracellular hyaluronan. JOURNAL OF BIOLOGICAL CHEMISTRY 276 23: 20428-20435. 2001

Tammi R, Rilla K, Pienimäki J-P, MacCallum DK, Hogg M, Luukkonen M, Hascall VC, Tammi M. 2001. Hyaluronan enters keratinocytes by a novel endocytic route for catabolism. JOURNAL OF BIOLOGICAL CHEMISTRY 276 37: 35111-35122. 2001

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