MARJA HEDMAN

Yhteystiedot

Avainsanat

Tutkimusryhmät ja -projektit

TUTKIMUSRYHMÄT - UEF

• 
  Sydänkirurgisen kuvantamisen tutkimusryhmä

Julkaisut

• Kauhanen, S. Petteri; Liimatainen, Timo; Korhonen, Miika; Parkkonen, Johannes; Vienonen, Juska; Vanninen, Ritva; Hedman, Marja. 2021. Pulmonary Artery Dilatation Is a Common Finding in a Coronary Artery CT Angiography Population In vivo 35 4: 2177-2185. 2021
• Tirronen, Annakaisa; Downes, Nicholas L; Huusko, Jenni; Laakkonen, Johanna P; Tuomainen, Tomi; Tavi, Pasi; Hedman, Marja; Ylä-Herttuala, Seppo. 2021. The Ablation of VEGFR-1 Signaling Promotes Pressure Overload-Induced Cardiac Dysfunction and Sudden Death Biomolecules 11 3: 452. 2021
• Hämäläinen, H; Corovai, A; Laitinen, J; Laitinen, TM; Hedman, M; Hedman, A; Kivelä, A; Laitinen, TP. 2020. Myocardial ischemia and previous infarction contribute to left ventricular dyssynchrony in patients with coronary artery disease Journal of nuclear cardiology [Published: 31 August 2020]: 1-11. 2020
• Onatsu, Juha; Vanninen, Ritva; Jäkälä, Pekka; Mustonen, Pirjo; Pulkki, Kari; Korhonen, Miika; Hedman, Marja; Höglund, Kina; Blennow, Kaj; Zetterberg, Henrik; Herukka, Sanna-Kaisa; Taina, Mikko. 2020. Tau, S100B and NSE as Blood Biomarkers in Acute Cerebrovascular Events In vivo 34 5: 2577-2586. 2020
• Simula Sakari, Muuronen Antti T, Taina Mikko, Jäkälä Pekka, Sipola Petri, Vanninen Ritva, Hedman Marja. 2013. Effect of middle cerebral artery territory ischemic stroke on QT interval. JOURNAL OF STROKE AND CEREBROVASCULAR DISEASES : THE OFFICIAL JOURNAL OF NATIONAL STROKE ASSOCIATION [Epub ahead of print]: 1-7. 2013
• Hedman M, Muona K, Hedman A, Kivelä A, Syvänne M, Eränen J, Rantala A, Stjernvall J, Nieminen MS, Hartikainen J, Ylä-Herttuala S. 2009. Eight-year safety follow-up of coronary artery disease patients after local intracoronary VEGF gene transfer. GENE THERAPY 16: 629-634. 2009
• Hedman M, Turunen MP, Ylä-Herttuala S. 2006. New technologies in cardiovascular research gene therapy. Teoksessa: Pasterkamp G, de Kleijn DPV (toim.) Cardiovascular Research. New Technologies, Methods, and Applications. Ei jufo-kustantaja/not jufo publisher. s. 85-101. 2006
• Wirth T, Hedman M, Mäkinen K, Manninen H, Immonen A, Vapalahti M, Ylä-Herttuala S. 2006. Safety profile of plasmid/liposomes and virus vectors on clinical gene therapy. CURRENT DRUG SAFETY 1: 253-257. 2006
• Bhardwaj S, Roy H, Kärpänen T, Hi Y, Jauhiainen S, Hedman M, Alitalo K, Ylä-Herttuala S. 2005. Periadventitial angiopoietin-1 gene transfer induces angiogenesis in rabbit carotid arteries. GENE THERAPY 12 5: 388-394. 2005
• Rutanen J, Rissanen TT, Markkanen JE, Gruchala M, Silvennoinen P, Kivelä A, Hedman A, Hedman M, Heikura T, Ordén M-R, Stacker SA, Achen MG, Hartikainen J, Ylä-Herttuala S.. 2004. Adenoviral catheter-mediated intramyocardial gene transfer using the mature form of vascular endothelial growth factor-D induces transmural angiogenesis in porcine heart. CIRCULATION 109: 1029-1035. 2004
• Bhardwaj S, Roy H, Gruchala M, Viita H, Kholova I, Kokina I, Achen MG, Stacker SA, Hedman M, Alitalo K, Ylä-Herttuala S. 2003. Angiogenic responses of vascular endothelial growth factors in periadventitial tissue HUMAN GENE THERAPY 14: 1451-1462. 2003
• Hedman M, Hartikainen J, Syvänne M, Stjernvall J, Hedman A, Kivelä A, Vanninen E, Mussalo H, Kauppila E, Simula S, Närvänen O, Rantala A, Peuhkurinen K, Nieminen MS, Laakso M, Ylä-Herttuala S. 2003. Safety and feasibility of catheter-based local intracoronary vascular endothelial growth factor gene transfer in the prevention of postangioplasty and in-stent restenosis and in the treatment of chronic myocardial ischemia: phase II [...]. CIRCULATION 107: 2677-2683. 2003
• Hiltunen MO, Turunen MP, Häkkinen TP, Rutanen J, Hedman M, Mäkinen K, Turunen A-M, Aalto-Setälä K, Ylä-Herttuala S. 2002. DNA hypomethylation and methyltransferase expression in atherosclerotic lesions. VASCULAR MEDICINE (LONDON) 7: 5-11. 2002
• Mäkinen K, Manninen H, Hedman M, Matsi P, Mussalo H, Alhava E, Ylä-Herttuala S. 2002. Increased vascularity detected by digital subtraction angiography after VEGF gene transfer to human lower limb artery: A randomized, placebo-controlled, double-blinded phase II study. MOLECULAR THERAPY 6 1: 127-133. 2002
• Laitinen M, Hartikainen J, Hiltunen MO, Eränen J, Kiviniemi M, Närvänen O, Mäkinen K, Manninen H, Syvänne M, Martin JF, Laakso M, Ylä-Herttuala S. 2000. Catheter-mediated vascular endothelial growth factor gene transfer to human coronary arteries after angioplasty. HUMAN GENE THERAPY 11: 263-270. 2000
• Pakkanen TM, Laitinen M, Hippeläinen M, Hiltunen MO, Alhava E, Ylä-Herttuala S. 2000. Periadventitial lacZ gene transfer to pig carotid arteries using a biodegradable collagen collar or a wrap of collagen sheet with adenoviruses and plasmid-liposome complexes. JOURNAL OF GENE MEDICINE 2: 52-60. 2000
• Hiltunen MO, Laitinen M, Turunen MP, Jeltsch M, Hartikainen J, Rissanen TT, Laukkanen J, Niemi M, Kossila M, Häkkinen TP, Kivelä A, Enholm B, Mansukoski H, Turunen A-M, Alitalo K, Ylä-Herttuala S. 2000. Intravascular adenovirus-mediated VEGF-C gene transfer reduces noeintima formation in balloon-denuded rabbit aorta. CIRCULATION 102: 2262-2268. 2000
• Hiltunen MO, Turunen MP, Turunen A-M, Rissanen TT, Laitinen M, Kosma V-M, Ylä-Herttuala S. 2000. Biodistribution of adenoviral vector to nontarget tissues after local in vivo gene transfer to arterial wall using intravastular and periadventitial gene delivery methods. FASEB JOURNAL 14: 2230-2236. 2000
• Hiltunen MO, Turunen MP, Laitinen M, Ylä-Herttuala S. 2000. Insights into the molecular pathogenesis of atherosclerosis and therapeutic strategies using gene transfer. VASCULAR MEDICINE (LONDON) 5: 41-48. 2000
• Hedman M, Ylä-Herttuala S. 2000. Gene therapy for the treatment of peripheral vascular disease and coronary artery disease. DRUGS OF TODAY 36: 609-617. 2000
• Laitinen M. 1999. Gene Transfer to the Arterial Wall-Preclinical and Clinical Studies. Kuopion yliopiston julkaisuja D. Lääketiede. 1999
• Pakkanen TM, Laitinen M, Hippeläinen M, Hiltunen MO, Lehtolainen P, Leppänen P, Luoma JS, Alhava E, Ylä-Herttuala S. 1999. Improved gene transfer efficiency in liver with vesicular stomatitis virus G-protein pseudotyped retrovirus after partial liver resection and thymidine kinase-ganciclovir pre-treatment PHARMACOLOGICAL RESEARCH 40 5: 451-457. 1999
• Pakkanen TM, Laitinen M, Hippeläinen M, Kallionpää H, Lehtolainen P, Leppänen P, Luoma JS, Tarvainen R, Alhava E, Ylä-Herttuala S. 1999. Enhanced plasma cholesterol lowering effect of retrovirus-mediated LDL receptor gene transfer to WHHL rabbit liver after improved surgical technique and stimulation of hepatocyte proliferation by combined partial liver res GENE THERAPY 6: 34-41. 1999
• Laitinen M, Mäkinen K, Manninen H, Matsi P, Kossila M, Agrawal RS, Pakkanen T, Luoma JS, Viita H, Hartikainen J, Alhava E, Laakso M, Ylä-Herttuala S. 1998. Adenovirus-mediated gene transfer to lower limb artery of patients with chronic critical leg ischemia HUMAN GENE THERAPY 9: 1481-1486. 1998
• Laitinen M, Ylä-Herttuala S. 1998. Adventitial gene transfer to arterial wall. PHARMACOLOGICAL RESEARCH 37 4: 251-254. 1998
• Laitinen M, Ylä-Herttuala S. 1998. Adventitial gene transfer to rabbit carotid arteries. Teoksessa: Jacotot B, Mathé D, Fruchart J-C (toim.), Atherosclerosis XI. XIth International Symposium on Atherosclerosis.Elsevier. ss. 689-691. 1998
• Laitinen M, Ylä-Herttuala S. 1998. Vascular gene transfer for the treatment of restenosis and atherosclerosis. CURRENT OPINION IN LIPIDOLOGY 9: 465-469. 1998
• Manninen HI, Vanninen RL, Laitinen M, Räsänen H, Vainio P, Luoma JS, Pakkanen T, Tulla H, Ylä-Herttuala S. 1998. Intravascular ultrasound and magnetic resonance imaging in the assessment of atherosclerotic lesions in rabbit aorta. Correlation to histopathologic findings. INVESTIGATIVE RADIOLOGY 33 8: 464-471. 1998
• Laitinen M, Pakkanen T, Donetti E, Baetta R, Luoma J, Lehtolainen P, Viita H, Agraval R, Miyanohara A, Friedmann T, Risau W, Martin JF, Soma M, Ylä-Herttuala S. 1997. Gene transfer into the carotid artery using an adventitial collar: Comparison of the effectiveness of the plasmid-liposome complexes, retroviruses, pseudotyped retroviruses, and adenoviruses HUMAN GENE THERAPY 8: 1645-1650. 1997
• Laitinen M, Ylä-Herttuala S. 1997. Genteknologins möjligheter vid hjärt- och kärlsjukdomar FINSK TIDSKRIFT 9-10: 527-536. 1997
• Laitinen M, Zachary I, Breier G, Pakkanen T, Häkkinen T, Luoma J, Abedi H, Risau W, Soma M, Laakso M, Martin JF, Ylä-Herttuala S. 1997. VEGF gene transfer reduces intimal thickening via increased production of nitric oxide in carotid arteries. HUMAN GENE THERAPY 8: 1737-1744. 1997