Markku Laakso

Metabolite Signature of Physical Activity and the Risk of Type 2 Diabetes in 7271 Men

Kemppainen, Susanna Maria; Silva, Lilian Fernandes; Lankinen, Maria Anneli; Schwab, Ursula; Laakso, Markku. Metabolites 12 1: 69. 2022

Large-scale association analyses identify host factors influencing human gut microbiome composition

Kurilshikov, Alexander; Medina-Gomez, Carolina; Bacigalupe, Rodrigo; Radjabzadeh, Djawad; Wang, Jun; Demirkan, Ayse; Le Roy, Caroline I.; Raygoza Garay, Juan Antonio; Finnicum, Casey T.; Liu, Xingrong; Zhernakova, Daria V.; Bonder, Marc Jan; Hansen, Tue H.; Frost, Fabian; Ruehlemann, Malte C.; Turpin, Williams; Moon, Jee-Young; Kim, Han-Na; Lull, Kreete; Barkan, Elad et al. (Incl Laakso, Markku). Nature genetics 53 2: 156-165. 2021

Machine Learning Reveals Time-Varying Microbial Predictors with Complex Effects on Glucose Regulation

Aasmets, Oliver; Lüll, Kreete; Lang, Jennifer M; Pan, Calvin; Kuusisto, Johanna; Fischer, Krista; Laakso, Markku; Lusis, Aldons J; Org, Elin. MSystems 6 1: e-01191-20. 2021

Elevated circulating follistatin associates with an increased risk of type 2 diabetes

Wu, CY; Borné, Y; Gao, R; Rodriguez, ML; Roell, WC; Wilson, JM; Regmi, A; Luan, C; Aly, DM; Peter, A; Machann, J; Staiger, H; Fritsche, A; Birkenfeld, AL; Tao, R; Wagner, R; Canouil, M; Hong, MG; Schwenk, JM [incl. Laakso, M]. Nature communications 12: 6486. 2021

Profiles of glucose metabolism in different prediabetes phenotypes, classified by fasting glycemia, 2-hour OGTT, glycated hemoglobin, and 1-hour OGTT: An IMI DIRECT study

Tura, Andrea; Grespan, Eleonora; Göbl, Christian S; Koivula, Robert W; Franks, Paul W; Pearson, Ewan R; Walker, Mark; Forgie, Ian M; Giordano, Giuseppe N; Pavo, Imre; Ruetten, Hartmut; Dermitzakis, Emmanouil T; McCarthy, Mark I; Pedersen, Oluf; Schwenk, Jochen M; Adamski, Jerzy; De Masi, Federico; Tsirigos, Konstantinos D; Brunak, Søren; Viñuela, Ana et al. [incl. Kokkola, Tarja; Vangipurapu Jaga. Diabetes 70 96: 2092-2106. 2021

Effect of lifestyle intervention on the risk of incident diabetes in individuals with impaired fasting glucose and low or high genetic risk for the development of type 2 diabetes in men: a T2D-GENE trial

Schwab, Ursula; Lankinen, Maria; Laakso, Markku. Food and nutrition research 65: 1-7. 2021

Insulin Resistance Is Associated With Enhanced Brain Glucose Uptake During Euglycemic Hyperinsulinemia: A Large-Scale PET Cohort

Rebelos, Eleni; Bucci, Marco; Karjalainen, Tomi; Oikonen, Vesa; Bertoldo, Alessandra; Hannukainen, Jarna C.; Virtanen, Kirsi A.; Latva-Rasku, Aino; Hirvonen, Jussi; Heinonen, Ilkka; Parkkola, Riitta; Laakso, Markku; Ferrannini, Ele; Iozzo, Patricia; Nummenmaa, Lauri; Nuutila, Pirjo. Diabetes care 44 3: 788-794. 2021

n-3 Fatty Acid Biomarkers and Incident Type 2 Diabetes: An Individual Participant-Level Pooling Project of 20 Prospective Cohort Studies

Qian, Frank; Korat, Andres V Ardisson; Imamura, Fumiaki; Marklund, Matti; Tintle, Nathan; Virtanen, Jyrki K; Zhou, Xia; Bassett, Julie K; Lai, Heidi; Hirakawa, Yoichiro; Chien, Kuo-Liong; Wood, Alexis C; Lankinen, Maria; Murphy, Rachel A; Samieri, Cecilia; Pertiwi, Kamalita; de Mello, Vanessa D; Guan, Weihua; Forouhi, Nita G; Wareham, Nick et al. (Incl Laakso, Markku). Diabetes care 44 5: 1133-1142. 2021

Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes

Pan, David Z; Miao, Zong; Comenho, Caroline; Rajkumar, Sandhya; Koka, Amogha; Lee, Seung Hyuk T; Alvarez, Marcus; Kaminska, Dorota; Ko, Arthur; Sinsheimer, Janet S; Mohlke, Karen L; Mancuso, Nicholas; Muñoz-Hernandez, Linda Liliana; Herrera-Hernandez, Miguel; Tusié-Luna, Maria Teresa; Aguilar-Salinas, Carlos; Pietiläinen, Kirsi H; Pihlajamäki, Jussi; Laakso, Markku; Garske, Kristina M; et al.. Genome medicine 13: 123. 2021

Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability

Mägi, Reedik; Hottenga, Jouke- Jan; Grallert, Harald; Perry, John R. B.; Bouatia-Naji, Nabila; Marullo, Letizia; Rybin, Denis; Jansen, Rick; Min, Josine L.; Dimas, Antigone S.; Ulrich, Anna; Zudina, Liudmila; Gådin, Jesper R.; Jiang, Longda; Faggian, Alessia; Bonnefond, Amélie; Fadista, Joao; Stathopoulou, Maria G.; Isaacs, Aaron; Willems, Sara M et al. [incl. Kuusisto, Johanna; Laakso, Markku; La. Nature communications 12 1: 24. 2021

FADS1 rs174550 genotype and high linoleic acid diet modify plasma PUFA phospholipids in a dietary intervention study

Meuronen, Topi; Lankinen, Maria A.; Kärkkäinen, Olli; Laakso, Markku; Pihlajamäki, Jussi; Hanhineva, Kati; Schwab, Ursula. European journal of nutrition 2022; 61 2: 1109-1120. 2021

Model-based assessment of replicability for genome-wide association meta-analysis

McGuire, Daniel; Jiang, Yu; Liu, Mengzhen; Weissenkampen, J. Dylan; Eckert, Scott; Yang, Lina; Chen, Fang; GWAS and Sequencing Consortium of Alcohol and Nicotine Use (GSCAN); Berg, Arthur; Vrieze, Scott; Jiang, Bibo; Li, Qunhua; Liu, Dajiang J. et al. [ incl. Laakso, Markku]. Nature communications 12 1: 1964. 2021

Molecular epidemiology of hereditary ataxia in Finland

Lipponen, Joonas; Helisalmi, Seppo; Raivo, Joose; Siitonen, Ari; Doi, Hiroshi; Rusanen, Harri; Lehtilahti, Maria; Ryytty, Mervi; Laakso, Markku; Tanaka, Fumiaki; Majamaa, Kari; Kytövuori, Laura. Bmc neurology 21 1: 382. 2021

The FADS1 Genotype Modifes Metabolic Responses to the Linoleic Acid and Alpha-linolenic Acid Containing Plant Oils-Genotype Based Randomized Trial FADSDIET2

Lankinen, MA; de Mello, VD; Meuronen, T; Sallinen, T; Ågren, J; Virtanen, KA; Laakso, M; Pihlajamäki, J; Schwab, U. Molecular nutrition and food research 65 7: 2001004. 2021

Chromatin accessibility and gene expression during adipocyte differentiation identify context-dependent effects at cardiometabolic GWAS loci

Perrin, Hannah J; Currin, Kevin W; Vadlamudi, Swarooparani; Pandey, Gautam K; Ng, Kenneth K; Wabitsch, Martin; Laakso, Markku; Love, Michael I; Mohlke, Karen L. PLoS genetics 17 10: e1009865. 2021

Sex-specific genetic regulation of adipose mitochondria and metabolic syndrome by Ndufv2

Krishnan, Karthickeyan Chella; Vergnes, Laurent; Acín-Pérez, Rebeca; Stiles, Linsey; Shum, Michael; Ma, Lijiang; Mouisel, Etienne; Pan, Calvin; Moore, Timothy M; Péterfy, Miklós; Romanoski, Casey E; Reue, Karen; Bjorkegren, Johan LM; Laakso, Markku; Liesa, Marc; Lusis, Aldons J. Nature metabolism 3 11: 1552-1568. 2021

The "Common Soil Hypothesis" Revisited - Risk Factors for Type 2 Diabetes and Cardiovascular Disease

Fernandes Silva, Lilian; Vangipurapu, Jagadish; Laakso, Markku. Metabolites 11 10: 691. 2021

Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes

Goodrich, JK; Singer-Berk, M; Son, R; Sveden, A; Wood, J; England, E; Cole, JB; Weisburd, B; Watts, N; Caulkins, L; Dornbos, P; Koesterer, R; Zappala, Z; Zhang, H; Maloney, KA; Dahl, A; Aguilar-Salinas, CA; Atzmon, G; Barajas-Olmos, F; Barzilai, N; et al; [incl. Kuusisto, J; Laakso, M]. Nature communications 12 1: 3505. 2021

Mitochondrial genome copy number measured by DNA sequencing in human blood is strongly associated with metabolic traits via cell-type composition differences

Ganel, Liron; Chen, Lei; Christ, Ryan; Vangipurapu, Jagadish; Young, Erica; Das, Indraniel; Kanchi, Krishna; Larson, David; Regier, Allison; Abel, Haley; Kang, Chul Joo; Scott, Alexandra; Havulinna, Aki; Chiang, Charleston WK; Service, Susan; Freimer, Nelson; Palotie, Aarno; Ripatti, Samuli; Kuusisto, Johanna; Boehnke, Michael; Laakso, Markku; Locke, Adam; Stitziel, Nathan O; Hall, Ira M. Human genomics 15 1: 1-17. 2021

Addendum: The mutational constraint spectrum quantified from variation in 141,456 humans

Gudmundsson, Sanna; Karczewski, Konrad J.; Francioli, Laurent C.; Tiao, Grace; Cummings, Beryl B.; Alföldi, Jessica; Wang, Qingbo; Collins, Ryan L.; Laricchia, Kristen M.; Ganna, Andrea; Birnbaum, Daniel P.; Gauthier, Laura D.; Brand, Harrison; Solomonson, Matthew; Watts, Nicholas A.; Rhodes, Daniel; Singer-Berk, Moriel; England, Eleina M.; Seaby, Eleanor G.; Kosmicki, Jack A. et al [incl. Hiltune. Nature 597 7874: E3-E4. 2021

SUR1-E1506K mutation impairs glucose tolerance and promotes vulnerable atherosclerotic plaque phenotype in hypercholesterolemic mice

Gurzeler, Erika; Ruotsalainen, Anna-Kaisa; Laine, Anssi; Valkama, Teemu; Kettunen, Sanna; Laakso, Markku; Ylä-Herttuala, Seppo. PLoS ONE 16 11: e025840. 2021

Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies

Harris, William S; Tintle, Nathan L; Imamura, Fumiaki; Qian, Frank; Korat, Andres V Ardisson; Marklund, Matti; Djousse, Luc; Bassett, Julie K; Carmichael, Pierre-Hugues; Chen, Yun-Yu; Hirakawa, Yoichiro; Kupers, Leanne K; Laguzzi, Federica; Lankinen, Maria; Murphy, Rachel A; Samieri, Cecilia; Senn, Mackenzie K; Shi, Peilin; Virtanen, Jyrki K; Brouwer, Ingeborg A et al; The Fatty Acids and Outcomes. Nature communications 12 1: 2329. 2021

Rare coding variants in 35 genes associate with circulating lipid levels - A multi-ancestry analysis of 170,000 exomes

Hindy, George; Dornbos, Peter; Chaffin, Mark D.; Liu, Dajiang J.; Wang, Minxian; Selvaraj, Margaret Sunitha; Zhang, David; Park, Joseph; Aguilar-Salinas, Carlos A.; Antonacci-Fulton, Lucinda; Ardissino, Diego; Arnett, Donna K.; Aslibekyan, Stella; Atzmon, Gil; Ballantyne, Christie M.; Barajas-Olmos, Francisco; Barzilai, Nir; Becker, Lewis C.; Bielak, Lawrence F.; Bis, Joshua C. et al [incl. Kuusis. American journal of human genetics 2022; 109 1: 81 - 96. 2021

The association of nine amino acids with cardiovascular events in Finnish men in a 12-year follow-up study

Jauhiainen, Raimo; Vangipurapu, Jagadish; Laakso, Annamaria; Kuulasmaa, Teemu; Kuusisto, Johanna; Laakso, Markku. Journal of clinical endocrinology and metabolism 106 12: 3448-3454. 2021

Evaluating drug targets through human loss-of-function genetic variation

Minikel, Eric Vallabh; Karczewski, Konrad J; Martin, Hilary C; Cummings, Beryl B; Whiffin, Nicola; Rhodes, Daniel; Alföldi, Jessica; Trembath, Richard C; van Heel, David A; Daly, Mark J; Genome Aggregation Database Production Team; Genome Aggregation Database Consortium; Schreiber, Stuart L; MacArthur, Daniel G [Incl. Hiltunen, Mikko; Laakso, Markku; Soininen, Hilkka]. Nature 581 7809: 459-464. 2020

Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

Surendran, Praveen; Feofanova, Elena V; Lahrouchi, Najim; Ntalla, Ioanna; Karthikeyan, Savita; Cook, James; Chen, Lingyan; Mifsud, Borbala; Yao, Chen; Kraja, Aldi T; Cartwright, James H; Hellwege, Jacklyn N; Giri, Ayush; Tragante, Vinicius; Thorleifsson, Gudmar; Liu, Dajiang J; Prins, Bram P; Stewart, Isobel D; Cabrera, Claudia P; Eales, James M; et al. (incl. Stanakova, Alena; Laatikainen, Tiina;. Nature genetics 52: 1314-1332. 2020

Simvastatin profoundly impairs energy metabolism in primary human muscle cells

Mäkinen, Selina; Datta, Neeta; Nguyen, Yen H; Kyrylenko, Petro; Laakso, Markku; Koistinen, Heikki A. Endocrine connections 9 11: 1103-1113. 2020

Clinical and Genetic Characterization of 153 Patients with Persistent or Transient Congenital Hyperinsulinism

Männistö, Jonna; Maria, Maleeha; Raivo, Joose; Kuulasmaa, Teemu; Otonkoski, Timo; Huopio, Hanna; Laakso, Markku. Journal of clinical endocrinology and metabolism 105 4: 1-9. 2020

Clinical profiles of post-load glucose subgroups and their association with glycaemic traits over time: an IMI-DIRECT study

Obura, M; Beulens, JWJ; Slieker, R; Koopman, ADM; Hoekstra, T; Nijpels, G; Elders, P; Dekker, JM; Koivula, RW; Kurbasic, A; Laakso, M; Hansen, TH; Ridderstråle, M; Hansen, T; Pavo, I; Forgie, I; Jablonka, B; Ruetten, H; Mari, A; McCarthy, MI; Walker, M; et al.. Diabetic medicine 2021; 38 2: e14428. 2020

Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes: An IMI-DIRECT study

Obura, Morgan; Beulens, Joline W J; Slieker, Roderick; Koopman, Anitra D M; Hoekstra, Trynke; Nijpels, Giel; Elders, Petra; Koivula, Robert W; Kurbasic, Azra; Laakso, Markku; Hansen, Tue H; Ridderstråle, Martin; Hansen, Torben; Pavo, Imre; Forgie, Ian; Jablonka, Bernd; Ruetten, Hartmut; Mari, Andrea; McCarthy, Mark I; Walker, Mark; et al.. PLoS ONE 15 11: e0242360. 2020

Generation of a human induced pluripotent stem cell line (UEFi003-A) carrying heterozygous A673T variant in amyloid precursor protein associated with a reduced risk of Alzheimer's disease

Rolova, Taisia; Wu, Ying-Chieh; Koskuvi, Marja; Voutilainen, Jenni; Sonninen, Tuuli-Maria; Kuusisto, Johanna; Laakso, Markku; Hämäläinen, Riikka H; Koistinaho, Jari; Lehtonen, Sárka. Stem cell research 48: 101968. 2020

Estrogen receptor α controls metabolism in white and brown adipocytes by regulating Polg1 and mitochondrial remodeling

Zhou, Zhenqi; Moore, Timothy M; Drew, Brian G; Ribas, Vicent; Wanagat, Jonathan; Civelek, Mete; Segawa, Mayuko; Wolf, Dane M; Norheim, Frode; Seldin, Marcus M; Strumwasser, Alexander R; Whitney, Kate A; Lester, Ellen; Reddish, Britany R; Vergnes, Laurent; Reue, Karen; Rajbhandari, Prashant; Tontonoz, Peter; Lee, Jason; Mahata, Sushil K et al [incl. Laakso, Markku]. Science translational medicine 12 555: eaax8096. 2020

Cardiomyopathy associated with the Ala143Thr variant of the α-galactosidase A gene

Valtola, K; Nino-Quintero, J; Hedman, M; Lottonen-Raikaslehto, L; Laitinen, T; Maria, M; Kantola, I; Naukkarinen, A; Laakso, M; Kuusisto, J. Heart 106 8: 609-615. 2020

Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus

van Zuydam, Natalie R; Ladenvall, Claes; Voight, Benjamin F; Strawbridge, Rona J; Fernandez-Tajes, Juan; Rayner, N William; Robertson, Neil R; Mahajan, Anubha; Vlachopoulou, Efthymia; Goel, Anuj; Kleber, Marcus E; Nelson, Christopher P; Kwee, Lydia Coulter; Esko, Tõnu; Mihailov, Evelin; Mägi, Reedik; Milani, Lili; Fischer, Krista; Kanoni, Stavroula; Kumar, Jitender; et al. [incl; Laakso, Markku]. Circulation 13 6: e002769. 2020

Microbiota-Related Metabolites and the Risk of Type 2 Diabetes

Vangipurapu, Jagadish; Fernandes Silva, Lilian; Kuulasmaa, Teemu; Smith, Ulf; Laakso, Markku. Diabetes care 43 6: 1319-1325. 2020

Landscape of multi-nucleotide variants in 125,748 human exomes and 15,708 genomes

Wang, Qingbo; Pierce-Hoffman, Emma; Cumings, Beryl B; Alföldi, Jessica; Francioli, Laurent C; Gauthier, Laura D; Hill, Andrew J; O'Donnell-Luria, Anne H; Genome Aggregation Database Production Team, Genome Aggregation Database Consortium [Incl. Hiltunen, Mikko; Laakso, Markku; Soininen, Hilkka]. Nature communications 11: 2539. 2020

The effect of LRRK2 loss-of-function variants in humans

Whiffin, Nicola; Armean, Irina M; Kleinman, Aaron; Marshall, Jamie L; Minikel, Eric V; Goodrich, Julia K; Quaife, Nicholas M; Cole, Joanne B; Wang, Qingbo; Karczewski, Konrad J; Cummings, Beryl B; Francioli, Laurent; Laricchia, Kristen; Guan, Anna; Alipanahi, Babak; Morrison, Peter; Baptista, Marco AS; Merchant, Kalpana M; Genome Aggregation Database Production Team; Genome Aggregation Database Co. Nature medicine 26: 869-877. 2020

Characterising the loss-of-function impact of 5' untranslated region variants in 15,708 individuals

Whiffin, Nicola; Karczewski, Konrad J; Zhang, Xiaolei; Chothani, Sonia; Smith, Miriam J; Evans, D Gareth; Roberts, Angharad M; Quaife, Nicholas M; Schafer, Sebastian; Rackham, Owen; Alföldi, Jessica; O'Donnell-Luria, Anne H; Francioli, Laurent C; Genome Aggregation Database Production Team, Genome Aggregation Database Consortium [Incl. Hiltunen, Mikko; Laakso, Markku; Soininen, Hilkka]. Nature communications 11: 2523. 2020

Efficient Estimation and Applications of Cross-Validated Genetic Predictions to Polygenic Risk Scores and Linear Mixed Models

Mefford, Joel; Park, Danny; Zheng, Zhili; Ko, Arthur; Ala-Korpela, Mika; Laakso, Markku; Pajukanta, Päivi; Yang, Jian; Witte, John; Zaitlen, Noah. Journal of computational biology 27 4: 599-612. 2020

The causal effect of obesity on prediabetes and insulin resistance reveals the important role of adipose tissue in insulin resistance

Miao, Zong; Alvarez, Marcus; Ko, Arthur; Bhagat, Yash; Rahmani, Elior; Jew, Brandon; Heinonen, Sini; Muñoz-Hernandez, Linda Liliana; Herrera-Hernandez, Miguel; Aguilar-Salinas, Carlos; Tusie-Luna, Teresa; Mohlke, Karen L; Laakso, Markku; Pietiläinen, Kirsi H; Halperin, Eran; Pajukanta, Päivi. PLoS genetics 16 9: e1009018. 2020

Adiponectin GWAS loci harboring extensive allelic heterogeneity exhibit distinct molecular consequences

Spracklen, Cassandra N; Iyengar, Apoorva K; Vadlamudi, Swarooparani; Raulerson, Chelsea K; Jackson, Anne U; Brotman, Sarah M; Wu, Ying; Cannon, Maren E; Davis, James P; Crain, Aaron T; Currin, Kevin W; Perrin, Hannah J; Narisu, Narisu; Stringham, Heather M; Fuchsberger, Christian; Locke, Adam E; et al. [incl. Laakso, Markku]. PLoS genetics 16 9: e1009019. 2020

Ryhmissä toteutettavalla elämäntapaohjauksella on merkittäviä tuloksia terveyteen

Lankinen, Maria; Schwab, Ursula; Laakso, Markku. KEHITTYVÄ ELINTARVIKE 3: 50-51. 2020

Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study

Gudmundsdottir, Valborg; Pedersen, Helle Krogh; Mazzoni, Gianluca; Allin, Kristine H; Artati, Anna; Beulens, Joline W; Banasik, Karina; Brorsson, Caroline; Cederberg, Henna; Chabanova, Elizaveta; De Masi, Federico; Elders, Petra J; Forgie, Ian; Giordano, Giuseppe N; Grallert, Harald; Gupta, Ramneek; Haid, Mark; Hansen, Torben; Hansen, Tue H; Hattersley, Andrew T; et al. [incl. Kokkola, Tarja; Laak. Genome medicine 12 1: 109. 2020

Voidaanko elintavoilla ehkäistä tyypin 2 diabtesta myös korkean geneettisen riskin omaavilla henkilöillä?

Lankinen, Maria; Laakso, Markku; Schwab, Ursula. Ravitsemusasiantuntija 6 1: 18-20. 2020

Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts

Atabaki-Pasdar, Naeimeh; Ohlsson, Mattias; Viñuela, Ana; Frau, Francesca; Pomares-Millan, Hugo; Haid, Mark; Jones, Angus G; Thomas, E Louise; Koivula, Robert W; Kurbasic, Azra; Mutie, Pascal M; Fitipaldi, Hugo; Fernandez, Juan; Dawed, Adem Y; Giordano, Giuseppe N; Forgie, Ian M; McDonald, Timothy J; Rutters, Femke; Cederberg, Henna; Chabanova, Elizaveta et al. [Incl. Kokkola, Tarja; Laakso Markku;. PLoS medicine 17 6: e1003149. 2020

A reference map of potential determinants for the human serum metabolome.

Bar, Noam; Korem, Tal; Weissbrod, Omer; Zeevi, David; Rothschild, Daphna; Leviatan, Sigal; Kosower, Noa; Lotan-Pompan, Maya; Weinberger, Adina; Le Roy, Caroline I; Menni, Cristina; Visconti, Alessia; Falchi, Mario; Spector, Tim D; Adamski, Jerzy; Franks, Paul W; Pedersen, Oluf; Segal, Eran; The IMI DIRECT Consortium [incl. Kuulasmaa, Teemu; Kokkola, Tarja; Laakso, Markku; Vangipurapu, Jagadish; Ce. Nature 588: 135-140. 2020

A structural variation reference for medical and population genetics

Collins, Ryan L; Brand, Harrison; Karczewski, Konrad J; Zhao, Xuefang; Alföldi, Jessica; Francioli, Laurent C; Khera, Armit V; Lowther, Chelsea; Gauthier, Laura D; Wang, Harold; Watts, Nicholas A; Solomonson, Matthew; O'Donnell-Luria, Anne; Baumann, Alexander; Munshi, Ruchi; Walker, Mark; Whelan, Christopher W; Huang, Yongqing; Brookings, Ted; Sharpe, Ted; et al.; Genome Aggregation Database Produ. Nature 581 7809: 444-451. 2020

Transcript expression-aware annotation improves rare variant interpretation

Cummings, Beryl B; Karczewski, Konrad J; Kosmicki, Jack A; Seaby, Eleanor G; Watts, Nicholas A; Singer-Berk, Moriel; Mudge, Jonathan M; Karjalainen, Juha; Satterstrom, F Kyle; O'Donnell-Luria, Anne H; Poterba, Timothy; Seed, Cotton; Solomonson, Matthew; Alföldi, Jessica; Genome Aggregation Database Production Team; Genome Aggregation Database Consortium; Daly, Mark J; MacArthur, Daniel G; et al. [. Nature 581 7809: 452-458. 2020

Genome-Wide Association Analysis of Pancreatic Beta Cell Glucose Sensitivity

Deshmukh, Harshal A; Madsen, Anne Lundager; Viñuela, Ana; Have, Christian Theil; Grarup, Niels; Tura, Andrea; Mahajan, Anubha; Heggie, Alison J; Koivula, Robert W; De Masi, Federico; Tsirigos, Konstantinos K; Linneberg, Allan; Drivsholm, Thomas; Pedersen, Oluf; Sørensen, Thorkild I A; Astrup, Arne; Gjesing, Anette A P; Pavo, Imre; Wood, Andrew R; Ruetten, Hartmut [et al incl. Laakso, Markku]. Journal of clinical endocrinology and metabolism 2021; 106 1: 80-90. 2020

Metabolite signature of albuminuria involves amino acid pathways in 8,661 Finnish men without diabetes

Fernandes Silva, Lilian; Vangipurapu, Jagadish; Smith, Ulf; Laakso, Markku. Journal of clinical endocrinology and metabolism 2021; 106 1: 143-152. 2020

Fgr kinase is required for proinflammatory macrophage activation during diet-induced obesity

Acín-Pérez, Rebeca; Iborra, Salvador; Martí-Mateos, Yolanda; Cook, Emma C L; Conde-Garrosa, Ruth; Petcherski, Anton; Muñoz, M Del Mar; Martínez de Mena, Raquel; Krishnan, Karthickeyan Chella; Jiménez, Concepción; Bolaños, Juan Pedro; Laakso, Markku; Lusis, Aldon J; Shirihai, Orian S; Sancho, David; Enríquez, José Antonio. Nature metabolism 2 9: 974-988. 2020

Mapping and characterization of structural variation in 17,795 human genomes

Abel, Haley J; Larson, David E; Regier, Allison A; Chiang, Colby; Das, Indraniel; Kanchi, Krishna L; Layer, Ryan M; Neale, Benjamin M; Salerno, William J; Reeves, Catherine Steven Buyske; NHGRI Centers for Common Disease Genomics; et al. [Incl. Laakso, Markku]. Nature 583: 83-89. 2020

Novel biomarkers associated with incident heart failure in 10 106 Finnish men

Jauhiainen, Raimo; Jauhiainen, Matti; Vangipurapu, Jagadish; Kuulasmaa, Teemu; Ala-Korpela, Mika; Laakso, Markku; Kuusisto, Johann. ESC heart failure 2021; 8 1: 605-614. 2020

Association Analysis and Meta-Analysis of Multi-Allelic Variants for Large-Scale Sequence Data

Jiang, Yu; Chen, Sai; Wang, Xingyan; Liu, Mengzhen; Iacono, William G; Hewitt, John K; Hokanson, John E; Krauter, Kenneth; Laakso, Markku; Li, Kevin W; Lutz, Sharon M; McGue, Matthew; Pandit, Anita; Zajac, Gregory J M; Boehnke, Michael; Abecasis, Goncalo R; Vrieze, Scott I; Jiang, Bibo; Zhan, Xiaowei; Liu, Dajiang J. Genes 11 5: 586. 2020

The mutational constraint spectrum quantified from variation in 141,456 humans

Karczewski, Konrad J; Francioli, Laurent C; Tiao, Grace; Cummings, Beryl B; Alföldi, Jessica; Wang, Qingbo; Collins, Ryan L; Laricchia, Kristen M; Ganna, Andre; Birnbaum, Daniel P; Gauthier, Laura D; Brand, Harrison; Solomonson, Matthew; Watts, Nicholas A; Rhodes, Daniel; Singer-Berk, Moriel; England, Eleina M; Seaby, Eleanor G; Kosmicki, Jack A; Walters, Raymond K; et al.; Genome Aggregation Dat. Nature 581 7809: 434-443. 2020

RIPK1 gene variants associate with obesity in humans and can be therapeutically silenced to reduce obesity in mice

Karunakaran, Denuja; Turner, Adam W; Duchez, Anne-Claire; Soubeyrand, Sebastien; Rasheed, Adil; Smyth, David; Cook, David P; Nikpay, Majid; Kandiah, Joshua W; Pan, Calvin; Geoffrion, Michele; Lee, Richard; Boytard, Ludovic; Wyatt, Hailey; Nguyen, My-Anh; Lau, Paulina; Laakso, Markku; Ramkhelawon, Bhama; Alvarez, Marcus; Pietiläinen, Kirsi H; et al.. Nature metabolism 2: 1113-1125. 2020

The Role of Physical Activity in Metabolic Homeostasis Before and After the Onset of Type 2 Diabetes: An IMI DIRECT Study

Koivula, RW; Atabaki-Pasdar, N; Giordano, GN; White, T; Adamski, J; Bell, JD; Beulens, J; Brage, S; Brunak, S; De Masi, F; Dermitzakis, ET; Forgie, IM; Frost, G; Hansen, T; Hansen, TH; Hattersley, A; Kokkola, T; Kurbasic, A; Laakso, M; Mari, A et al. for the IMI DIRECT Consortium. Diabetologia 63 4: 744-756. 2020

Gamma-glutamyltransferase, arterial remodeling and prehypertension in a healthy population at low cardiometabolic risk

Kozakova, M; Gastaldelli, A; Morizzo, C; Højlund, K; Nilssson, PM; Ferrannini, E; RISC Investigators; Palombo, C; et al. [incl Laakso, M; Räisänen, R]. Journal of human hypertension 2021; 35 4: 334-342. 2020

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New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders

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Genetic Determinants of Circulating Glycine Levels and Risk of Coronary Artery Disease

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A Strategy for Discovery of Endocrine Interactions with Application to Whole-Body Metabolism

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Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes

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A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure

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Interactions between genetic variation and cellular environment in skeletal muscle gene expression

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Identification of seven novel loci associated with amino acid levels using single-variant and gene-based tests in 8545 Finnish men from the METSIM study

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A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes

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Functional Variant in the GCKR Gene Affects Lactate Levels Differentially in the Fasting State and During Hyperglycemia

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Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

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Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition

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Systems Genetics Approach to Biomarker Discovery: GPNMB and Heart Failure in Mice and Humans

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Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

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Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

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Phenotype-Specific Enrichment of Mendelian Disorder Genes near GWAS Regions across 62 Complex Traits

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Fatty acid biomarkers of dairy fat consumption and incidence of type 2 diabetes: A pooled analysis of prospective cohort studies

Imamura, F; Fretts, A; Marklund, M; Ardisson Korat, AV; Yang, WS; Lankinen, M; Qureshi, W; Helmer, C; Chen, TA; Wong, K; Bassett, JK; Murphy, R; Tintle, N; Yu, CI; Brouwer, IA; Chien, KL; Frazier-Wood, AC; Del Gobbo, LC; Djoussé, L; Geleijnse, JM; et al (incl. Lankinen, Maria; Laakso, Markku; Uusitupa, Matti). PLoS medicine 15 10: e100267. 2018

Quantifying the Impact of Rare and Ultra-rare Coding Variation across the Phenotypic Spectrum

Ganna, A; Satterstrom, FK; Zekavat, SM; Das, I; Kurki, MI; Churchhouse, C; Alfoldi, J; Martin, AR; Havulinna, A; Byrnes, A; Thompson, WK; Nielsen, PR; Karczewski, K; Saarentaus, E; Rivas, MA; Gupta, N; Pietiläinen, O; Emdin, CA; Lescai, F; Bybjerg-Grauholm, J; et al. (incl. Laakso, Markku). American journal of human genetics 102 6: 1204-1211. 2018

Novel electrocardiographic features in carriers of hypertrophic cardiomyopathy causing sarcomeric mutations

Jalanko, Mikko; Heliö, Tiina; Mustonen, Pirjo; Kokkonen, Jorma; Huhtala, Heini; Laine, Mika; Jääskeläinen, Pertti; Tarkiainen, Mika; Lauerma, Kirsi; Sipola, Petri; Laakso, Markku; Kuusisto, Johanna; Nikus, Kjell. Journal of electrocardiology 51 6: 983-989. 2018

Proper conditional analysis in the presence of missing data: Application to large scale meta-analysis of tobacco use phenotypes

Jiang, Y; Chen, S; McGuire, D; Chen, F; Liu, M; Iacono, WG; Hewitt, JK; Hokanson, JE; Krauter, K; Laakso, M; Li, KW; Lutz, SM; McGue, M; Pandit, A; Zajac, GJM; Boehnke, M; Abecasis, GR; Vrieze, SI; Zhan, X; Jiang, B; et al.. PLoS genetics 14 7: e1007452. 2018

Structural Immaturity of Human iPSC-Derived Cardiomyocytes: In Silico Investigation of Effects on Function and Disease Modeling

Koivumäki, Jussi T; Naumenko, Nikolay; Tuomainen, Tomi; Takalo, Jouni; Oksanen, Minna; Puttonen, Katja A; Lehtonen, Sarka; Kuusisto, Johanna; Laakso, Markku; Koistinaho, Jari; Tavi, Pasi. Frontiers in Physiology 9: 80. 2018

A Common Type 2 Diabetes Risk Variant Potentiates Activity of an Evolutionarily Conserved Islet Stretch Enhancer and Increases C2CD4A and C2CD4B Expression

Kycia, I; Wolford, BN; Huyghe, JR; Fuchsberger, C; Vadlamudi, S; Kursawe, R; Welch, RP; Albanus, RD; Uyar, A; Khetan, S; Lawlor, N; Bolisetty, M; Mathur, A; Kuusisto, J; Laakso, M; Ucar, D; Mohlke, KL; Boehnke, M; Collins, FS; Parker, SCJ; et al.. AMERICAN JOURNAL OF HUMAN GENETICS 102 4: 620-635. 2018

A Partial Loss-of-Function Variant in AKT2 Is Associated With Reduced Insulin-Mediated Glucose Uptake in Multiple Insulin-Sensitive Tissues: A Genotype-Based Callback Positron Emission Tomography Study

Latva-Rasku, A; Honka, MJ; Stancáková, A; Koistinen, HA; Kuusisto, J; Guan, L; Manning, AK; Stringham, H; Gloyn, AL; Lindgren, CM; T2D-GENES Consortium; Collins, FS; Mohlke, KL; Scott, LJ; Karjalainen, T; Nummenmaa, L; Boehnke, M; Nuutila, P; Laakso, M. DIABETES (NY) 67 2: 334-342. 2018

Generation of a human induced pluripotent stem cell line from a patient with a rare A673T variant in amyloid precursor protein gene that reduces the risk for Alzheimer's disease

Lehtonen, S; Höytyläinen, I; Voutilainen, J; Sonninen, T-M; Kuusisto, J; Laakso, M; Hämäläinen, RH; Oksanen, M; Koistinaho, J. Stem cell research 30: 96-99. 2018

Correction: The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue

Schugar RC, Shih DM, Warrier M, Helsley RN, Burrows A, Ferguson D, Brown AL, Gromovsky AD, Heine M, Chatterjee A, Li L, Li XS, Wang Z, Willard B, Meng Y, Kim H, Che N, Pan C, Lee RG, Crooke RM et al.. Cell reports 20 1: 279. 2017

Acute detachment of hexokinase II from mitochondria modestly increases oxygen consumption of the intact mouse heart

Nederlof R, Denis S, Lauzier B, Rosiers CD, Laakso M, Hagen J, Argmann C, Wanders R, Houtkooper RH, Hollmann MW, Houten SM, Zuurbier CJ. METABOLISM: CLINICAL AND EXPERIMENTAL 72: 66-74. 2017

Family-specific aggregation of lipid GWAS variants confers the susceptibility to familial hypercholesterolemia in a large Austrian family

Nikkola Elina, Ko Arthur, Alvarez Marcus, Cantor Rita M, Garske Kristina, Kim Elliot, Gee Stephanie, Rodriguez Alejandra, Muxel Reinhard, Matikainen Niina, Söderlund Sanni, Motazacker Mahdi M, Borén Jan, Lamina Claudia, Kronenberg Florian, Schneider Wolfgang J, Palotie Aarno, Laakso Markku, Taskinen Marja-Riitta, Pajukanta Päivi. ATHEROSCLEROSIS 264: 58-66. 2017

Relationships between gut microbiota, plasma metabolites, and metabolic syndrome traits in the METSIM cohort

Org E, Blum Y, Kasela S, Mehrabian M, Kuusisto J, Kangas AJ, Soininen P, Wang ZN, Ala-Korpela M, Hazen SL, Laakso M, Lusis AJ. GENOME BIOLOGY [ONLINE] 18: 70. 2017

Heterozygous RFX6 protein truncating variants are associated with MODY with reduced penetrance

Patel KA, Kettunen J, Laakso M, Stancáková A, Laver TW, Colclough K, Johnson MB, Abramowicz M, Groop L, Miettinen PJ, Shepherd MH, Flanagan SE, Ellard S, Inagaki N1, Hattersley AT, Tuomi T, Cnop M, Weedon MN. Nature Communications 8: 888. 2017

Predicting glycated hemoglobin levels in the non-diabetic general population: Development and validation of the DIRECT - DETECT prediction model - a DIRECT study

Rauh Simone P, Heymans Martijn W, Koopman Anitra DM, Nijpels Giel, Stehouwer Coen D, Thorand Barbara, Rathmann Wolfgang, Meisinger Christa, Peters Annette, de las Heras Gala Tonia, Glümer Charlotte, Pedersen Olut, Cederberg Henna, Kuusisto Johanna, Laakso Markku, Pearson Ewan R, Franks Paul W, Rutters Femke, Dekker Jacqueline M. PLOS ONE 12 2: e0171816. 2017

A Type 2 Diabetes-Associated Functional Regulatory Variant in a Pancreatic Islet Enhancer at the Adcy5 Locus

Roman TS, Cannon ME, Vadlamudi S, Buchkovich ML, Wolford BN, Welch RP, Morken MA, Kwon GJ, Varshney A, Kursawe R, Wu Y, Jackson AU, Erdos MR, Kuusisto J, Laakso M, Scott LJ, Boehnke M, Collins FS, Parker SCJ, Stitzel ML, Mohlke KL. DIABETES (NY) 66 9: 2521-2530. 2017

A nationwide study on parathyroid carcinoma

Ryhänen EM, Leijon H, Metso S, Eloranta E, Korsoff P, Ahtiainen P, Kekäläinen P, Tamminen M, Ristamäki R, Knutar O, Löyttyniemi E, Niskanen L, Väisänen M, Heiskanen I, Välimäki MJ, Laakso M, Haglund C, Arola J, Schalin-Jäntti C. ACTA ONCOLOGICA 56 7: 991-1003. 2017

Omega-6 fatty acid biomarkers and incident type 2 diabetes: pooled analysis of individual-level data for 39 740 adults from 20 prospective cohort studies

Wu JHY, Marklund M, Imamura F, Tintle N, Ardisson Korat AV, de Goede J, Zhou X, Yang WS, de Oliveira Otto MC, Kröger J, Qureshi W, Virtanen JK, Bassett JK, Frazier-Wood AC, Lankinen M, Murphy RA, Rajaobelina K, Del Gobbo LC, Forouhi NG, Luben R, Khaw KT, Wareham N, Kalsbeek A, Veenstra J, Luo J, Hu FB, Lin HJ, Siscovick DS, Boeing H, Chen TA, Steffen B, Steffen LM, Hodge A, Eriksdottir G, Smith AV. The Lancet Diabetes & Endocrinology 5 12: 965-974. 2017

The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue

Schugar RC, Shih DM, Warrier M, Helsley RN, Burrows A, Ferguson D, Brown AL, Gromovsky AD, Heine M, Chatterjee A, Li L, Li XS, Wang Z, Willard B, Meng Y, Kim H, Che N, Pan C, Lee RG, Crooke RM et al.. Cell Reports 19 12: 2451-2461. 2017

Genetic risk scores in the prediction of plasma glucose, impaired insulin secretion, insulin resistance and incident type 2 diabetes in the METSIM study

Stancakova Alena, Kuulasmaa Teemu, Kuusisto Johanna, Mohlke Karen L, Collinis Francis S, Boehnke Michael, Laakso Markku. DIABETOLOGIA 60 9: 1722-1730. 2017

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T, Giri A, Graff M, Guo X, Hendricks AE, Karaderi T, Lempradl A, Locke AE, Mahajan A, Marouli E, Sivapalaratnam S, Young KL, Alfred T et al. (incl. Laakso Markku, Lakka Timo, Uusitupa Matti). NATURE GENETICS 50; 2018 1: 26-41. 2017

The influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimer's pathology

Westwood S, Liu B, Baird AL, Anand S, Nevado-Holgado AJ, Newby D, Pikkarainen M, Hallikainen M, Kuusisto J, Streffer JR, Novak G, Blennow K, Andreasson U, Zetterberg H, Smith U, Laakso M, Soininen H, Lovestone S. Alzheimer's research and therapy 9: 31. 2017

Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis

Wheeler E, Leong A, Liu CT, Hivert MF, Strawbridge RJ, Podmore C, Li M, Yao J, Sim X, Hong J, Chu AY, Zhang W, Wang X, Chen P, Maruthur NM, Porneala BC, Sharp SJ, Jia Y, Kabagambe EK, Chang LC et al. (incl. Kuusisto J, Laakso M). PLOS ONE 14 9: 1002383. 2017

A Genome-Wide Association Study of IVGTT-Based Measures of First Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants

Wood AR, Jonsson A, Jackson AU, Wang N, van Leewen N, Palmer ND, Kobes S, Deelen J, Boquete-Vilarino L, Paananen J, Stancáková A, Boomsma DI, de Geus EJ, Eekhoff EM, Fritsche A, Kramer M, Nijpels G, Simonis-Bik A, van Haeften TW, Mahajan A et al (Incl. Laakso Markku). DIABETES (NY) 66 8: 2296-2309. 2017

Decreased plasma ß-amyloid in the Alzheimer's disease APP A673T variant carriers

Martiskainen H, Herukka SK, Stancáková A, Paananen J, Soininen H, Kuusisto J, Laakso M, Hiltunen M. ANNALS OF NEUROLOGY 82 1: 128-132. 2017

Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

Zillikens M Carola, Demissie Serkalem, Hsu Yi-Hsiang, Yerges-Armstrong Laura M, Chou Wen-Chi, Stolk Lisette, Livshits Gregory, Broer Linda, Johnson Toby, Koller Daniel L, Kutalik Zoltán, Luan Jian'an, Malkin Ida, Ried Janina S, Smith Albert V, Thorleifsson Gudmar, Vandenput Liesbeth, Zhao Jing Hua, Zhang Weihua, Aghdassi Ali et al. (incl. Cederberg Henna, Kuulasmaa Teemu, Kuusisto Johanna, Laak. Nature Communications 8: 80. 2017

Plant-derived compounds strigolactone GR24 and pinosylvin activate SIRT1 and enhance glucose uptake in rat skeletal muscle cells

Modi S, Yaluri N, Kokkola T, Laakso M. Scientific Reports 7: 17606. 2017

Plasma Mannose Levels Are Associated with Incident Type 2 Diabetes and Cardiovascular Disease

Mardinoglu Adil, Stancáková Alena, Lotta Luca A, Kuusisto Johanna, Boren Jan, Blüher Matthias, Wareham Nicholas J, Ferrannini Ele, Groop Per Henrik, Laakso Markku, Langenberg Claudia, Smith Ulf. Cell Metabolism 26 2: 281-283. 2017

Rare and low-frequency coding variants alter human adult height

Marouli Eirini, Graff Mariaelisa, Medina-Gomez Carolina, Sin Lo Ken, Wood Andrew R, Kjaer Troels R, Fine Rebecca S, Lu Yingchang, Schurmann Claudia, Highland Heather M, Rüeger Sina, Thorleifsson Gudmar, Justice Anne E, Lamparter David, Stirrups Kathleen E, Turcot Valérie, Young Kristin L, Winkler Thomas W, Esko Tõnu, Karaderi Tugce et al. (incl Kuusisto Johanna, Laakso Markku, Lakka Timo A). Nature 542: 186-190. 2017

Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

Jason F, Fuchsberger C, Mahajan A, Teslovich TM, Agarwala V, Gaulton KJ, Caulkins L, Koesterer R, Ma C, Moutsianas L, McCarthy DJ, Rivas MA, Perry JRB, Sim X, Blackwell TW, Robertson NR, Rayner NW, Cingolani P, Locke AE, Tajes JF et al. (incl. Kuulasmaa Teemu, Kuusisto Johanna, Laakso Markku). Scientific Data 4: 170179. 2017

Genomic correlates of glatiramer acetate adverse cardiovascular effects lead to a novel locus mediating coronary risk

Braenne Ingrid, Zeng Lingyao, Willenborg Christina, Tragante Vinicius, Kessler Thorsten, Willer Cristen J, Laakso Markku, Wallentin Lars, Franks Paul W, Salomaa Veikko, Dehghan Abbas, Meitinger Thomas, Samani Nilesh J, Asselbergs Folkert W, Erdmann Jeanette, Schunkert Heribert, CARDIoGRAM Consortium, CARDIoGRAMplusC4D Consortium. PLOS ONE 12 8: e0182999. 2017

A genomic exploration identifies mechanisms that may explain adverse cardiovascular effects of COX-2 inhibitors

Brænne I, Willenborg C, Tragante V, Kessler T, Zeng L, Reiz B, Kleinecke M, von Ameln S, Willer CJ, Laakso M, Wild PS, Zeller T, Wallentin L, Franks PW, Salomaa V, Dehghan A, Meitinger T, Samani NJ, Asselbergs FW, Erdmann J et al.. Scientific Reports 7: 10252. 2017

Role of osteopontin and its regulation in pancreatic islet

Cai M, Bompada P, Salehi A, Acosta JR, Prasad RB, Atac D, Laakso M, Groop L, De Marinis Y. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2018; 495 1: 1426-1431. 2017

Genetic Regulation of Adipose Gene Expression and Cardio-Metabolic Traits

Civelek M, Wu Y, Pan C, Raulerson CK, Ko A, He A, Tilford C, Saleem NK, Stancáková A, Scott LJ, Fuchsberger C, Stringham HM, Jackson AU, Narisu N, Chines PS, Small KS, Kuusisto J, Parks BW, Pajukanta P, Kirchgessner T et al. AMERICAN JOURNAL OF HUMAN GENETICS 100 3: 428-443. 2017

Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study

Davis JP, Huyghe JR, Locke AE, Jackson AU, Sim X, Stringham HM, Teslovich TM, Welch RP, Fuchsberger C, Narisu N, Chines PS, Kangas AJ, Soininen P, Ala-Korpela M, Kuusisto J, Collins FS, Laakso M, Boehnke M, Mohlke KL. PLOS GENETICS [ONLINE) 13 10: e1007079. 2017

Differential Associations of Inflammatory Markers With Insulin Sensitivity and Secretion: The Prospective METSIM Study

Fizelova M, Jauhiainen R, Kangas AJ, Soininen P, Ala-Korpela M, Kuusisto J, Laakso M, Stancáková A. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 102 9: 3600-3609. 2017

Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults

Graff M, Scott RA, Justice AE, Young KL, Feitosa MF, Barata L, Winkler TW, Chu AY, Mahajan A, Hadley D, Xue L, Workalemahu T, Heard-Costa NL, den Hoed M, Ahluwalia TS, Qi Q, Ngwa JS, Renström F, Quaye L, Eicher JD et al.. PLOS GENETICS [ONLINE) 13 4: e1006528. 2017

Trans-ancestry Fine Mapping and Molecular Assays Identify Regulatory Variants at the ANGPTL8 HDL-C GWAS Locus

Cannon ME, Duan Q, Wu Y, Zeynalzadeh M, Xu Z, Kangas AJ, Soininen P, Ala-Korpela M, Civelek M, Lusis AJ, Kuusisto J, Collins FS, Boehnke M, Tang H, Laakso M, Li Y, Mohlke K. G3: Genes, genomes, Genetics 7 9: 3217-3227. 2017

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

Justice Anne E, Winkler Thomas W, Feitosa Mary F, Graff Misa, Fisher Virginia A, Young Kristin, Barata Llilda, Deng Xuan, Czajkowski Jacek, Hadley David, Ngwa Julius S, Ahluwalia Tarunveer S, Chu Audrey Y, Heard-Costa Nancy L, Lim Elise, Perez Jeremiah, Eicher John D, Kutalik Zoltan, Xue Luting, Mahajan Anubha et al.. Nature Communications 8: 14977. 2017

New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals

Kraja Aldi T, Cook James P, Warren Helen R, Surendran Praveen, Liu Chunyu, Evangelou Evangelos, Mannig Alisa K, Grarup Niels, Drenos Fotios, Sim Xueling, Smith Albert Vernon, Amin Najaf, Blakemore Alexandra I F, Bork-Jensen Jette, Brandslund Ivan, Farmaki Aliki-Eleni, Fava Cristiano, Ferreira Teresa, Herzig Karl-Heinz, Giri Ayush et al.. Circulation: Cardiovascular Genetics 10 5: e001778. 2017

The Metabolic Syndrome in Men study: a resource for studies of metabolic and cardiovascular diseases

Laakso Markku, Kuusisto Johanna, Stancakova Alena, Kuulasmaa Teemu, Pajukanta Päivi, Jake Lusis Aldons, Collins Francis S, Mohlke Karen, Boehnke Michael. JOURNAL OF LIPID RESEARCH 58 3: 481-493. 2017

Diabetes secondary to treatment with statins

Laakso Markku, Kuusisto Johanna. Current Diabetes Reports 17 2: 1-9. 2017

Exome-wide association study of plasma lipids in >300,000 individuals

Liu DJ, Peloso GM, Yu H, Butterworth AS, Wang X, Mahajan A, Saleheen D, Emdin C, Alam D, Alves AC, Amouyel P, Di Angelantonio E, Arveiler D, Assimes TL, Auer PL, Baber U, Ballantyne CM, Bang LE, Benn M, Bis JC et al.. NATURE GENETICS 49 12: 1758-1766. 2017

Elevated Plasma Levels of 3-Hydroxyisobutyric Acid Are Associated With Incident Type 2 Diabetes

Mardinoglu A, Gogg S, Lotta LA, Stancáková A, Nerstedt A, Boren J, Blüher M, Ferrannini E, Langenberg C, Wareham NJ, Laakso M, Smith U. EBioMedicine 2018; 27: 151-155. 2017

Identification and characterization of a FOXA2-regulated transcriptional enhancer at a type 2 diabetes intronic locus that controls GCKR expression in liver cells

López Rodríguez M, Kaminska D, Lappalainen K, Pihlajamäki J, Kaikkonen MU, Laakso M. Genome Medicine 9: 63. 2017

A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk

Manning A, Highland HM, Gasser J, Sim X, Tukiainen T, Fontanillas P, Grarup N, Rivas MA, Mahajan A, Locke AE, Cingolani P, Pers TH, Viñuela A, Brown AA, Wu Y, Flannick J, Fuchsberger C, Gamazon ER, Gaulton KJ, Im HK et al. (incl. Lakka Timo, Kuulasmaa Teemu, Laakso Markku, Uusitupa Matti). DIABETES (NY) 66 7: 2019-2032. 2017

Novel association of TM6SF2 rs58542926 genotype with increased serum tyrosine levels and decreased apoB-100 particles in Finns

Kim DS, Jackson AU, Li YK, Stringham HM, FinMetSeq Investigators, Kuusisto J, Kangas AJ, Soininen P, Ala-Korpela M, Burant CF, Salomaa V, Boehnke M, Laakso M, Speliotes EK. JOURNAL OF LIPID RESEARCH 58 7: 1471-1481. 2017

Genetics of Type 2 Diabetes

Stancáková A, Laakso M. Teoksessa: Stettler C, Crist E, Diem P (toim.) Novelties in Diabetes. S. karger Vol. 31. s. 203-220. 2016

A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape

Ried JS, Jeff M J, Chu AY, Bragg-Gresham JL, van Dongen J, Huffman JE, Ahluwalia TS, Cadby G, Eklund N, Eriksson J, Esko T, Feitosa MF, Goel A, Gorski M, Hayward C, Heard-Costa NL, Jackson AU, Jokinen E, Kanoni S, Kristiansson K et al. Nature Communications 7: 13357. 2016

Molecular characterization of the lipid genome-wide association study signal on chromosome 18q11.2 implicates HNF4A-mediated regulation of the TMEM241 gene

Rodríguez Alejandra, Gonzalez Luis, Ko Arthur, Alvarez Marcus, Miao Zong, Bhagat Yash, Nikkola Elina, Cruz-Bautista Ivette, Arellano-Campos Olimpia, Muñoz-Hernández Linda L, Ordóñez-Sánchez Maria-Luisa, Rodriguez-Guillen Rosario, Mohlke Karen L, Laakso Markku, Tusie-Luna Teresa, Aguilar-Salinas Carlos A, Pajukanta Päivi. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 36 7: 1350-5. 2016

The genetic regulatory signature of type 2 diabetes in human skeletal muscle

Scott Laura J, Erdos Michael R, Huyghe Jeroen R, Welch Ryan P, Beck Andrew T, Wolford Brooke N, Chines Peter S, Didion John P, Narisu Narisu, Stringham Heather N, Taylor D Leeland, Jackson Anne U, Vadlamudi Swarooparani, Bonnycastle Bonny M, Kinnunen Leena, Saramies Jouko, Sundvall Jouko, D'Oliveira Albanus Ricardo, Kiseleva Anna, Hensley John et al (inc. LakkaTimo A, Laakso Markku). Nature Communications 7: 11764. 2016

A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease

Scott Robert A, Freitag Daniel F, Li Li, Chu Audrey Y, Surendran Praveen, Young Robin, Grarup Niels, Stancáková Alena, Chen Yuning, Varga Tibor V, Yaghootkar Hanieh, Luan Jian'an, Zhao Jing Hua, Willems Sara M, Wessel Jennifer, Wang Shuai, Maruthur Nisa, Michailidou Kyriaki, Pirie Ailith, van der Lee Sven J et al. SCIENCE TRANSLATIONAL MEDICINE 8 341: pp. 341ra76. 2016

Fatty acid metabolism is altered in non-alcoholic steatohepatitis independent of obesity

Walle Paula, Takkunen Markus, Männistö Ville, Vaittinen Maija, Lankinen Maria, Kärjä Vesa, Käkelä Pirjo, Ågren Jyrki, Tiainen Mika, Schwab Ursula, Kuusisto Johanna, Laakso Markku, Pihlajamäki Jussi. METABOLISM 65 5: 655-666. 2016

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

Surendran P, Drenos F, Young R, Warren H, Cook JP, Manning AK, Grarup N, Sim X, Barnes DR, Witkowska K, Staley JR, Tragante V, Tukiainen T, Yaghootkar H, Masca N, Freitag DF, Ferreira T, Giannakopoulou O, Tinker A, Harakalova M et al. NATURE GENETICS 48: 1151-1161. 2016

Short adult stature predicts impaired beta-cell function, insulin resistance, glycemia and type 2 diabetes in Finnish men

Vangipurapu Jagadish, Stancakova Alena, Jauhiainen Raimo, Kuusisto Johanna, Laakso Markku. Journal of clinical endocrinology and metabolism 2017: 102 2: 443-450. 2016

Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci

Walford GA, Gustafsson S, Rybin D, Stancáková A, Chen H, Liu CT, Hong J, Jensen RA, Rice K, Morris AP, Mägi R, Tönjes A, Prokopenko I, Kleber ME, Delgado G, Silbernagel G, Jackson AU, Appel EV, Grarup N, Lewis JP et al.. DIABETES (NY) 65 10: 3200-3211. 2016

Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

Winkler Thomas W, Justice Anne E, Graff Mariaelisa, Barata Llilda, Feitosa Mary F, Chu Su, Czajkowski Jacek, Esko Tõnu, Fall Tove, Kilpeläinen Tuomas O, Lu Yingchang, Mägi Reedik, Mihailov Evelin, Pers Tune H, Rüeger Sina, Teumer Alexander, Ehret Georg B, Ferreira Teresa, Heard-Costa Nancy L, Karjalainen Juha et al. PLOS GENETICS [ONLINE) 12 6: e1006166. 2016

Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease

Zanoni Paolo, Khetarpal Sumeet A, Larach Daniel B, Hancock-Cerutti William F, Millar John S, Cuchel Marina, DerOhannessian Stephanie, Kontush Anatol, Surendran Praveen, Saleheen Danish, Trompet Stella, Jukema J Wouter, De Craen Anton, Deloukas Panos, Sattar Naveed, Ford Ian, Packard Chris, Majumder Abdullah al Shafi , Alam Dewan S, Di Angelantonio Emanuele et al. SCIENCE 351 6278: 1166-1171. 2016

Quantifying prion disease penetrance using large population control cohorts

Minikel Eric Vallabh, Vallabh Sonia M, Lek Monkol, Estrada Karol, Samocha Kaitlin E, Sathirapongsasuti J Fah, McLean Cory Y, Tung Joyce Y, Yu Linda PC, Gambetti Pierluigi, Blevins Janis, Zhang Shulin, Cohen Yvonne, Chen Wei, Yamada Masahito, Hamaguchi Tsuyoshi, Sanjo Nobuo, Mizusawa Hidehiro, Nakamura Yosikazu, Kitamoto Tetsuyuki et al. SCIENCE TRANSLATIONAL MEDICINE 8 322: 322ra9. 2016

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

Pattaro Christian, Teumer Alexander, Gorski Mathias, Chu Audrey Y, Li Man, Mijatovic Vladan, Garnaas Maija, Tin Adrienne, Sorice Rossella, Li Yong, Taliun Daniel, Olden Matthias, Foster Meredith, Yang Qiong, Chen Ming-Huei, Pers Tune H, Johnson Andrew D, Ko Yi-An, Fuchsberger Christian, Tayo Bamiele et al.. Nature Communications 7: 10023. 2016

SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function

Li M, Li Y, Weeks O, Mijatovic V, Teumer A, Huffman JE, Tromp G, Fuchsberger C, Gorski M, Lyytikäinen LP, Nutile T, Sedaghat S, Sorice R, Tin A, Yang Q, Ahluwalia TS, Arking DE, Bihlmeyer NA, Böger CA, Carroll RJ et al.. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 2017; 28 3: 981-994. 2016

Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes

Marso SP, Daniels GH, Brown-Frandsen K, Kristensen P, Mann JF, Nauck MA, Nissen SE, Pocock S, Poulter NR, Ravn LS, Steinberg WM, Stockner M, Zinman B, Bergenstal RM, Buse JB, LEADER Steering Committee, LEADER Trial Investigators. NEW ENGLAND JOURNAL OF MEDICINE 375 4: 311-322. 2016

Clinical, Genetic, and Biochemical Characteristics of Early-Onset Diabetes in the Finnish Population

Huopio Hanna, Miettinen Päivi J, Ilonen Jorma, Nykänen Päivi, Veijola Riitta, Keskinen Päivi, Näntö-Salonen Kirsti, Vangipurapu Jagadish, Raivo Joose, Stancáková Alena, Männistö Jonna, Kuulasmaa Teemu, Knip Mikael, Otonkoski Timo, Laakso Markku. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 101 8: 3018-3026. 2016

Detection of novel gene variants associated with congenital hypothyroidism in a Finnish patient cohort

Löf Christoffer, Patyra Konrad, Kuulasmaa Teemu, Vangipurapu Jagadish, Undeutsch Henriette, Jäschke Holger, Pajunen Tuulia, Kero Andreina, Krude Heiko, Biebermann Heike, Kleinau Gunnar, Kühnen Peter, Rantakari Krista, Miettinen Päivi, Kirjavainen Turkka, Pursiheimo Juha-Pekka, Mustila Taina, Jääskeläinen Jarmo, Ojaniemi Marja, Toppari Jorma et al. THYROID 26 9: 1215-1224. 2016

Epigenetic regulation of the thioredoxin-interacting protein (TXNIP) gene by hyperglycemia in kidney

De Marinis Yang, Cai Mengyin, Bompada Pradeep, Atac David, Kotova Olga, Johansson Martin E, Garcia-Vaz Eliana, Gomez Maria F, Laakso Markku, Groop Leif. KIDNEY INTERNATIONAL 89 2: 342-353. 2016

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

Ehret GB, Ferreira T, Chasman DI, Jackson AU, Schmidt EM, Johnson T, Thorleifsson G, Luan J, Donnelly LA, Kanoni S, Petersen AK, Pihur V, Strawbridge RJ, Shungin D, Hughes MF, Meirelles O, Kaakinen M, Bouatia-Naji N, Kristiansson K, Shah S et al.. NATURE GENETICS 48 10: 1171-1184. 2016

Finnish Diabetes Risk Score Is Associated with Impaired Insulin Secretion and Insulin Sensitivity, Drug-Treated Hypertension and Cardiovascular Disease: A Follow-Up Study of the METSIM Cohort

Fizelova Maria, Jauhiainen Raimo, Stancáková Alena, Kuusisto Johanna, Laakso Markku. PLOS ONE 11 11: e0166584. 2016

Integrative approaches for large-scale transcriptome-wide association studies

Gusev Alexander, Ko Arthur, Shi Huwendo, Bhatia Gaurav, Chung Wonil, Penninx Brenda WJH, Jansen Rick, de Geus Eco JC, Boomsma Dorret I, Wright Fred A, Sullivan Patrick F, Nikkola Elina, Alvarez Marcus, Civelek Mete, Lusis Aldons J, Lehtimäki Terho, Raitoharju Emma, Kähönen Mika, Seppälä Ilkka, Raitakari Olli T et al. NATURE GENETICS 48: 245-252. 2016

The genetic architecture of type 2 diabetes

Fuchsberger Christian, Flannick Jason, Teslovich Tanya M, Mahajan Anubha, Agarwala Vineeta, Gaulton Kyle J, Ma Clement, Fontanillas Pierre, Moutsianas Loukas, McCarthy Davis J, Rivas Manuel A, Perry John RB, Sim Xueling, Blackwell Thomas W, Robertson Neil R, Rayner N William, Cingolani Pablo, Locke Adam E, Tajes Juan Fernandes, Highland Heather M, (incl Kuulasmaa Teemu). NATURE (LONDON) 536: 41-47. 2016

Left ventricular mechanical dispersion is associated with nonsustained ventricular tachycardia in hypertrophic cardiomyopathy

Jalanko Mikko, Tarkiainen Mika, Sipola Petri, Jääskeläinen Pertti, Lauerma Kirsi, Laine Mika, Nieminen Markku S, Laakso Markku, Heliö Tiina, Kuusisto Johanna. Annals of Medicine: 2016 Jun 1:1-11. [Epub ahead of print]. 2016

Regulation of alternative splicing in human obesity loci

Kaminska Dorota, Käkelä Pirjo, Nikkola Elina, Venesmaa Sari, Ilves Imre, Herzig Karl-Heinz, Kolehmainen Marjukka, Karhunen Leila, Kuusisto Johanna, Gylling Helena, Pajukanta Päivi, Laakso Markku, Pihlajamäki Jussi. Obesity 24 10: 2033-2037. 2016

Diabetes

Laakso Markku, Groop Leif, Honkasalo Mikko, Isomaa Bo, Juselius Päivi, Lindström Jaana, Meinander Tuula, Nuutinen Helena, Saltevo Juha, Syvänne Mikko, Tuomi Tiinamaija. DUODECIM 132 9: 881-882. 2016

Integrated network analysis reveals an association between plasma mannose levels and insulin resistance

Lee Sunjae, Zhang Cheng, Kilicarslan Murat, Piening Brian D, Bjornson Elias, Hallström Björn M, Groen Albert K, Ferrannini Ele, Laakso Markku, Snyder Michael, Blüher Matthias, Uhlen Mathias, Nielsen Jens, Smith Ulf, Serlie Mireille J, Boren Jan, Mardinoglu Adil. Cell Metabolism 24 1: 172-84. 2016

Analysis of protein-coding genetic variation in 60,706 humans

Lek M, Karczewski KJ, Minikel EV, Samocha KE, Banks E, Fennell T, O'Donnell-Luria AH, Ware JS, Hill AJ, Cummings BB, Tukiainen T, Birnbaum DP, Kosmicki JA, Duncan LE, Estrada K, Zhao F, Zou J, Pierce-Hoffman E, Berghout J, Cooper DN et al. NATURE (LONDON) 536: 285-291. 2016

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

Lu Yingchang, Day Felix R, Gustafsson Stefan, Buchkovich Martin L, Na Jianbo, Bataille Veronique, Cousminer Diana L, Dastani Zari, Drong Alexander W, Esko Tönu, Evans David M, Falchi Mario, Feitosa Mary F, Ferreira Teresa, Hedman Åsa K, Haring Robin, Hysi Pirro G, Iles Mark M, Justice Anne E, Kanoni Stavroula et al. Nature Communications 7: 10495. 2016

Influence of endogenous NEFA on beta cell function in humans

Rebelos Eleni, Seghieri Marta, Natali Andrea, Balkau Beverly, Golay Alain, Piatti Pier Marco, Lalic Nebojsa M, Laakso Markku, Mari Andrea, Ferrannini Ele. DIABETOLOGIA 58 10: 2344-2351. 2015

Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus

Mahajan Anubha, Sim Xueling, Ng Hui Jin, Manning Alisa, Rivas Manuel A, Highland Heather M, Locke Adam E, Grarup Niels, Im Hae Kyung, Cingolani Pablo, Flannick Jason, Fontanillas Pierre, Fuchsberger Christian, Gaulton Kyle J, Teslovich Tanya M, Rayner N William, Robertson Neil R, Beer Nicola L, Rundle Jana K, Bork-Jensen Jette et al. On Behalf of the T2D-GENES consortium and GoT2D consortium. PLOS GENETICS [ONLINE) 11 1: e1004876. 2015

Genetic risk clustering increases children's body weight at 2 years of age - the STEPS Study

Mäkelä J, Lagström H, Pitkänen N, Kuulasmaa T, Kaljonen A, Laakso M, Niinikoski H. PEDIATRIC OBESITY [epub ahead of print 11 Dec 2015]: -. 2015

Urinary adiponectin is an independent predictor of progression to end-stage renal disease in patients with type 1 diabetes and diabetic nephropathy

Panduru Nicolae M, Saraheimo Markku, Forsblom Carol, Thorn Lena M, Gordin Daniel, Wadén Johan, Tolonen Nina, Bierhaus Angelika, Humpert Per M, Groop Per-Henrik on behalf of the FinnDiane Study Group (incl. Markku Laakso). DIABETES CARE 38 5: 883-90. 2015

Biological interpretation of genome-wide association studies using predicted gene functions

Pers Tune H, Karjalainen Juha M, Chan Yingleong, Westra Harm-Jan, Wood Andrew R, Yang Jian, Lui Julian C, Vedantam Sailaja, Gustafsson Stefan, Esko Tonu, Frayling Tim, Speliotes Elizabeth K, Genetic Investigation of ANthropometric Traits (GIANT) Consortium (incl. Johanna Kuusisto, Markku Laakso, Timo Lakka, Matti Uusitupa), Boehnke Michael, Raychaudhuri Soumya, Fehrmann Rudolf SN, Hirschhorn Joel . Nature Communications 6: 5890. 2015

Dietary polyunsaturated fatty acids and the Pro12Ala polymorphisms of PPARG regulate serum lipids through divergent pathways: a randomized crossover clinical trial

Pihlajamäki Jussi, Schwab Ursula, Kaminska Dorota, Ågren Jyrki, Kuusisto Johanna, Kolehmainen Marjukka, Paananen Jussi, Laakso Markku, Uusitupa Matti. Genes and Nutrition 10 6: 43. 2015

Simvastatin Impairs Insulin Secretion by Multiple Mechanisms in MIN6 Cells

Yaluri Nagendra, Modi Shalem, López Rodríguez Maykel, Stancáková Alena, Kuusisto Johanna, Kokkola Tarja, Laakso Markku. PLOS ONE [ONLINE] 10 11: e0142902. 2015

Multiple Hepatic Regulatory Variants at the GALNT2 GWAS Locus Associated with High-Density Lipoprotein Cholesterol

Roman Tamara S, Marvelle Amanda F, Fogarty Marie P, Vadlamudi Swarooparani, Gonzalez Arlene J, Buchkovich Martin L, Huyghe Jeroen R, Fuchsberger Christian, Jackson Anne U, Wu Ying, Civelek Mete, Lusis Aldons J, Gaulton Kyle J, Sethupathy Praveen, Kangas Antti J, Soininen Pasi, Ala-Korpela Mika, Kuusisto Johanna, Collins Francis S, Laakso Markku, Boehnke Michael, Mohlke Karen L.. AMERICAN JOURNAL OF HUMAN GENETICS 97 6: 801-815. 2015

New genetic loci link adipose and insulin biology to body fat distribution

Shungin Dmitry, Winkler Thomas W, Croteau-Chonka Damien C, Ferreira Teresa, Locke Adam E, Mägi Reedik, Strawbridge Rona J, Pers Tune H, Fischer Krista, Justice Anne E, Workalemahu Tsegaselassie, Wu Joseph MW, Buchkovich Martin L, Heard-Costa Nancy L, Roman Tamara S, Drong Alexander W, Song Ci, Gustafsson Stefan, Day Felix R, Esko Tonu et al. NATURE (LONDON) 518 7538: 187-196. 2015

Gene-diet interaction of a common FADS1 variant with marine polyunsaturated fatty acids for fatty acid composition in plasma and erythrocytes among men

Takkunen Markus J, de Mello Vanessa D, Schwab Ursula S, Kuusisto Johanna, Vaittinen Maija, Ågren Jyrki J, Laakso Markku, Pihlajamäki Jussi, Uusitupa MI. Molecular Nutrition & Food Research 2016; 60 2: 381-389. 2015

Both fasting and glucose-stimulated proinsulin levels predict hyperglycemia and incident type 2 diabetes: a population-based study of 9,396 finnish men

Vangipurapu Jagadish, Stancáková Alena, Kuulasmaa Teemu, Kuusisto Johanna, Laakso Markku. PLOS ONE [ONLINE] 10 4: e0124028. 2015

Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility

Wessel Jennifer, Chu Audrey Y, Willems Sara M, Wang Shuai, Yaghootkar Hanieh, Brody Jennifer A, Dauriz Marco, Hivert Marie-France, Raghavan Sridharan, Lipovich Leonard, Hidalgo Bertha, Fox Keolu, Huffman Jennifer E, An Ping, Lu Yingchang, Rasmussen-Torvik Laura J, Grarup Niels, Ehm Margaret G, Li Li, Baldridge Abigail S et al. Nature Communications 6: 5897. 2015

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

Winkler Thomas W, Justice Anne E, Graff Mariaelisa, Barata Llilda, Feitosa Mary F, Chu Su, Czajkowski Jacek, Esko Tõnu, Fall Tove, Kilpeläinen Tuomas O, Lu Yingchang, Mägi Reedik, Mihailov Evelin, Pers Tune H, Rüeger Sina, Teumer Alexander, Ehret Georg B, Ferreira Teresa, Heard-Costa Nancy L, Karjalainen Juha et al. PLOS GENETICS [ONLINE) 11 10: e1005378. 2015

Association analysis of 29,956 individuals confirms that a low-frequency variant at CCND2 halves the risk of type 2 diabetes by enhancing insulin secretion

Yaghootkar Hanieh, Stancáková Alena, Freathy Rachel M, Vangipurapu Jagadish, Weedon Michael N, Xie Weijia, Wood Andrew R, Ferrannini Ele, Mari Andrea, Ring Susan M, Lawlor Debbie A, Smith George Davey, Jørgensen Torben, Hansen Torben, Pedersen Oluf, Steinthorsdottir Valgerdur, Guðbjartsson Daniel F, Thorleifsson Gudmar, Thorsteinsdottir Unnur, Stefansson Kari et al. DIABETES (NY) 64 6: 2279-2285. 2015

Genetic studies of body mass index yield new insights for obesity biology

Locke Adam E, Kahali Bratati, Berndt Sonja I, Justice Anne E, Pers Tune H, Day Felix R, Powell Corey, Vedantam Sailaja, Buchkovich Martin L, Yang Jian, Croteau-Chonka Damien C, Esko Tonu, Fall Tove, Ferreira Teresa, Gustafsson Stefan, Kutalik Zoltán, Luan Jian'an, Mägi Reedik, Randall Joshua C, Winkler Thomas W et al. NATURE (LONDON) 518 7538: 197-206. 2015

Plasma fatty acids as predictors of glycaemia and type 2 diabetes

Lankinen Maria A, Stancáková Alena, Uusitupa Matti, Ågren Jyrki, Pihlajamäki Jussi, Kuusisto Johanna, Schwab Ursula, Laakso Markku. DIABETOLOGIA 58 11: 2533-2544. 2015

Is Insulin Resistance a Feature of or a Primary Risk Factor for Cardiovascular Disease?

Laakso Markku. Current Diabetes Reports 15 105: 1-9. 2015

Genetically determined height and coronary artery disease

Christopher P. Nelson, Stephen E. Hamby, Danish Saleheen, Jenna C. Hopewell, Lingyao Zeng, Themistocles L. Assimes, Stavroula Kanoni, Christina Willenborg, Stephen Burgess, Phillipe Amouyel, Sonia Anand, Stefan Blankenberg, Bernhard O. Boehm, Robert J. Clarke, Rory Collins, George Dedoussis, Martin Farrall, Paul W. Franks, Leif Groop, Alistair S. Hall et al. for the CARDIoGRAM+C4D Consortium (inic. NEW ENGLAND JOURNAL OF MEDICINE 372: 1608-1618. 2015

Treatment with the dipeptidyl peptidase-4 inhibitor linagliptin or placebo followed by glimepiride in patients with type 2 diabetes with moderate to severe renal impairment: a 52-week, randomized, double-blind clinical trial

Laakso Markku, Rosenstock Julio, Groop Per-Henrik, Barnett Anthony H, Gallwitz Baptist, Hehnke Uwe, Tamminen Ilkka, Patel Sanjay, Von Eynatten Maximilian, Woerle Hans-Juergen. DIABETES CARE 38 2: e15-e17. 2015

Glucose-Dependent Insulinotropic Polypeptide (GIP) Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB

Berglund Lisa M, Lyssenko Valeriya, Ladenvall Claes, Kotova Olga, Edsfeldt Andreas, Pilgaard Kasper, Alkayyali Sami, Brøns Charlotte, Forsblom Carol, Jonsson Anna, Zetterqvist Anna V, Nitulescu Mihaela, McDavitt Christian Ruiz, Dunér Pontus, Stancáková Alena, Kuusisto Johanna, Ahlqvist Emma, Lajer Maria, Tarnow Lise, Madsbad Sten et al. DIABETES (NY) (2016) 65 1: 239-254. 2015

Epigenetic regulation of glucose-stimulated osteopontin (OPN) expression in diabetic kidney

Cai M, Bompada P, Atac D, Laakso M, Groop L, De Marinis Y. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2016; 469 1: 108-113. 2015

Type 2 diabetes mellitus and dyslipidemia

Cederberg Henna, Laakso Markku. Teoksessa: Abhimanyu Garg (toim.) Dyslipidemias : Pathophysiology, Evaluation and Management. Humana press. s. 99-113. 2015

Variable effects of statins on glucose homeostasis parameters and their diabetogenic role. Reply to Kostapanos MS, Agouridis AP and Elisaf MS [letter

Cederberg Henna, Laakso Markku. DIABETOLOGIA 58 8: 1962-3. 2015

Increased risk of diabetes with statin treatment is associated with impaired insulin sensitivity and insulin secretion: a 6 year follow-up study of the METSIM cohort

Cederberg Henna, Stancáková Alena, Yaluri Nagendra, Modi Shalem, Kuusisto Johanna, Laakso Markku. DIABETOLOGIA 58 5: 1109-1117. 2015

LMNA Mutation c.917T>G (p.L306R) Leads to Deleterious Hyper-Assembly of Lamin A/C and Associates with Severe Right Ventricular Cardiomyopathy and Premature Aging

Alastalo Tero-Pekka, West Gun, Li Song-Ping, Keinänen Anni, Helenius Mikko, Tyni Tiina, Lapatto Risto, Turanlahti Maila, Heikkilä Päivi, Kääriäinen Helena, Laakso Markku, Mauermann Monika, Herrmann Harald, Pihkala Jaana, Taimen Pekka. HUMAN MUTATION 36 7: 694-703. 2015

Associations of multiple lipoprotein and apolipoprotein measures with worsening of glycemia and incident type 2 diabetes in 6607 non-diabetic Finnish men

Fizelova Maria, Miilunpohja Manna, Kangas Antti J, Soininen Pasi, Kuusisto Johanna, Ala-Korpela Mika, Laakso Markku, Stancáková Alena. ATHEROSCLEROSIS 240 1: 272-277. 2015

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

Gaulton KJ, Ferreira T, Lee Y, Raimondo A, Mägi R, Reschen ME, Mahajan A, Locke A, William Rayner N, Robertson N, Scott RA, Prokopenko I, Scott LJ, Green T, Sparso T, Thuillier D, Yengo L, Grallert H, Wahl S, Frånberg M et al.. NATURE GENETICS 47: 1415-1425. 2015

The Metabolome in Finnish Carriers of the MYBPC3-Q1061X Mutation for Hypertrophic Cardiomyopathy

Jorgenrud Benedicte, Jalanko Mikko, Heliö Tiina, Jääskeläinen Pertti, Laine Mika, Hilvo Mika, Nieminen Markku S., Laakso Markku, Hyötyläinen Tuulia, Oresic Matej, Kuusisto Johanna. PLOS ONE [ONLINE] 10 8: e0134184. 2015

Directional dominance on stature and cognition in diverse human populations

Joshi Peter K, Esko Tonu, Mattsson Hannele, Eklund Niina, Gandin Ilaria, Nutile Teresa, Jackson Anne U, Schurmann Claudia, Smith Albert V, Zhang Weihua, Okada Yukinori, Stancáková Alena, Faul Jessica D, Zhao Wei, Bartz Traci M, Pina Concas Maria, Franceschini Nora, Enroth Stefan, Vitart Veronique, Trompet Stella et al (incl. Kuusisto Johanna, Laakso Markku). NATURE (LONDON) 523: 459-462. 2015

A new strategy for enhancing imputation quality of rare variants from next-generation sequencing data via combining SNP and exome chip data

Kim Young Jin, Lee Juyoung, Kim Bong-Jo, Park Taesung, T2D-Genes Consortium (incl. Laakso Markku). BMC GENOMICS [ONLINE:HTTP://WWW.BIOMEDCENTRAL.COM/BMCGENOMICS/] 16: 1109. 2015

Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene

Knowles Joshua W, Xie Weijia, Zhang Zhongyang, Chennemsetty Indumathi, Assimes Themistocles L, Paananen Jussi, Hansson Ola, Pankow James, Goodarzi Mark O, Carcamo-Orive Ivan, Morris Andrew P, Chen Yii-Der I, Mäkinen Ville-Petteri, Ganna Andrea, Mahajan Anubha, Guo Xiuqing, Abbasi Fahim, Greenawalt Danielle M, Lum Pek, Molony Cliona et al. JOURNAL OF CLINICAL INVESTIGATION 125 4: 1739-1751. 2015

Glycated hemoglobin levels are mostly dependent on nonglycemic parameters in 9398 Finnish men without diabetes

Fizelova Maria, Stancáková Alena, Lorenzo Carlos, Haffner Steven M, Cederberg Henna, Kuusisto Johanna, Laakso Markku. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 100 5: 1989-1996. 2015

Genome-wide Enrichment Analysis between Endometriosis and Obesity-related Traits Reveals Novel Susceptibility Loci

Rahmioglu Nilufer, Macgregor Stuart, Drong Alexander W, Hedman Åsa K, Harris Holly R, Randall Joshua C, Prokopenko Inga, The International EndoGene Consortium (IEC), The GIANT Consortium, Nyholt Dale R, Morris Andrew P, Montgomery Grant W, Missmer Stacey A, Lindgren Cecilia M, Zondervan Krina T. HUMAN MOLECULAR GENETICS Epub ahead of print: -. 2014

Fasting and OGTT-derived measures of insulin resistance as compared with the euglycemic-hyperinsulinemic clamp in non-diabetic Finnish offspring of type 2 diabetic individuals

Lorenzo Carlos, Haffner Steven M, Stancáková Alena, Kuusisto Johanna, Laakso Markku. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 2015; 100 2: 544-550. 2014

Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes

Majithia Amit R, Flannick Jason, Shahinian Peter, Guo Michael, Bray Mark-Anthony, Fontanillas Pierre, Gabriel Stacey B, GoT2D Consortium, NHGRI JHS/FHS Allelic Spectrum Project, SIGMA T2D Consortium, T2D-GENES Consortium, Rosen Evan D, Altshuler David (including Laakso Markku). PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111 36: 13127-13132. 2014

Ketone body production is differentially altered in steatosis and non-alcoholic steatohepatitis in obese humans

Männistö Ville T, Simonen Marko, Hyysalo Jenni, Soininen Pasi, Kangas Antti J, Kaminska Dorota, Matte Ananda K, Venesmaa Sari, Käkelä Pirjo, Kärjä Vesa, Arola Johanna, Gylling Helena, Cederberg Henna, Kuusisto Johanna, Laakso Markku, Yki-Järvinen Hannele, Ala-Korpela Mika, Pihlajamäki Jussi. Liver International 2015; 35 7: 1853-1861. 2014

Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes

Ng MC, Shriner D, Chen BH, Li J, Chen WM, Guo X, Liu J, Bielinski SJ, Yanek LR, Nalls MA, Comeau ME, Rasmussen-Torvik LJ, Jensen RA, Evans DS, Sun YV, An P, Patel SR, Lu Y, Long J, Armstrong LL et al. (including Kuusisto J, Laakso M). PLOS GENETICS [ONLINE) 10 8: e1004517. 2014

A Central Role for GRB10 in Regulation of Islet Function in Man

Prokopenko Inga, Poon Wenny, Mägi Reedik, Prasad BR, Salehi S Albert, Almgren Peter, Osmark Peter, Bouatia-Naji Nabila, Wierup Nils, Fall Tove, Stancáková Alena, Barker Adam, Lagou Vasiliki, Osmond Clive, Xie Weijia, Lahti Jari, Jackson Anne U, Cheng Yu-Ching, Liu Jie, O'Connell Jeffrey R et al. (including Kuusisto Johanna, Laakso Markku, Lakka Timo). PLOS GENETICS [ONLINE) 10 4: e1004235. 2014

Prolonged P wave duration predicts stroke mortality among type 2 diabetic patients with prevalent non-major macrovascular disease

Vepsäläinen Teemu, Laakso Markku, Lehto Seppo, Juutilainen Auni, Airaksinen Juhani, Rönnemaa Tapani. BMC CARDIOVASCULAR DISORDERS [ONLINE: HTTP://WWW.BIOMEDCENTRAL.COM/1471-2261/] 14: 168. 2014

Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico

SIGMA Type 2 Diabetes Consortium, Williams AL, Jacobs SB, Moreno-Macías H, Huerta-Chagoya A, Churchhouse C, Márquez-Luna C, García-Ortíz H, Gómez-Vázquez MJ, Burtt NP, Aguilar-Salinas CA, González-Villalpando C, Florez JC, Orozco L, Haiman CA, Tusié-Luna T, Altshuler D (including Laakso M). NATURE (LONDON) 506 6: 97-101. 2014

Genetics of metabolic syndrome

Stancakova A, Laakso M. REVIEWS IN ENDOCRINE AND METABOLIC DISORDERS 15 4: 243-252. 2014

High-fat diet increases tau expression in the brain of T2DM and AD mice independently of peripheral metabolic status

Takalo M, Haapasalo A, Martiskainen H, Kurkinen KM, Koivisto H, Miettinen P, Khandelwal VK, Kemppainen S, Kaminska D, Mäkinen P, Leinonen V, Pihlajamäki J, Soininen H, Laakso M, Tanila H, Hiltunen M. JOURNAL OF NUTRITIONAL BIOCHEMISTRY 25 6: 634-641. 2014

Quality control and conduct of genome-wide association meta-analyses

Winkler Thomas W, Day Felix R, Croteau-Chonka Damien C, Wood Andrew R, Locke Adam E, Mägi Reedik, Ferreira Teresa, Fall Tove, Graff Mariaelisa, Justice Anne E, Luan Jian'an, Gustafsson Stefan, Randall Joshua C, Vedantam Sailaja, Workalemahu Tsegaselassie, Kilpeläinen Tuomas O, Scherag André, Esko Tonu, Kutalik Zoltán, Heid Iris M, The Genetic Investigation of Anthropometric Traits (GIANT) Consorti. NATURE PROTOCOLS 9 5: 1192-1212. 2014

Defining the role of common variation in the genomic and biological architecture of adult human height

Wood Andrew R, Esko Tonu, Yang Jian, Vedantam Sailaja, Pers Tune H, Gustafsson Stefan, Chu Audrey Y, Estrada Karol, Luan Jian'an, Kutalik Zoltán, Amin Najaf, Buchkovich Martin L, Croteau-Chonka Damien C, Day Felix R, Duan Yanan, Fall Tove, Fehrmann Rudolf, Ferreira Teresa, Jackson Anne U, Karjalainen Juha et.al.. NATURE GENETICS 46 11: 1173-86. 2014

Distribution and medical impact of loss-of-function variants in the Finnish founder population

Lim Elaine T, Würtz Peter, Havulinna Aki S, Palta Priit, Tukiainen Taru, Rehnström Karola, Esko Tõnu, Mägi Reedik, Inouye Michael, Lappalainen Tuuli, Chan Yingleong, Salem Ranu M, Lek Monkol, Flannick Jason, Sim Xueling, Manning Alisa, Ladenvall Claes, Bumpstead Suzannah, Hämäläinen Eija, Aalto Kristiina et al., (including Laakso Markku). PLOS GENETICS [ONLINE) 10 7: e1004494. 2014

Multi-ethnic fine-mapping of 14 central adiposity loci

Liu CT, Monda KL, Taylor KC, Lange L, Demerath EW, Palmas W, Wojczynski MK, Ellis JC, Vitolins MZ, Liu S, Papanicolaou GJ, Irvin MR, Xue L, Griffin PJ, Nalls MA, Adeyemo A, Liu J, Li G, Ruiz-Narvaez EA, Chen WM et al. (including Kuusisto J, Laakso M). HUMAN MOLECULAR GENETICS 23 17: 4738-4744. 2014

Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: rationale and design of the epidemiological studies within the IMI DIRECT Consortium

Koivula RW, Heggie A, Barnett A, Cederberg H, Hansen TH, Koopman AD, Ridderstråle M, Rutters F, Vestergaard H, Gupta R, Herrgård S, Heymans MW, Perry MH, Rauh S, Siloaho M, Teare HJ, Thorand B, Bell J, Brunak S, Frost G, et al. (including Laakso M). DIABETOLOGIA 57 6: 1132-1142. 2014

Insulin resistance and hyperglycaemia in cardiovascular disease development

Laakso Markku, Kuusisto Johanna. NATURE REVIEWS ENDOCRINOLOGY 10: 293-302. 2014

Loss-of-function mutations in SLC30A8 protect against type 2 diabetes

Flannick Jason, Thorleifsson Gudmar, Beer Nicola L, Jacobs Suzanne BR, Grarup Niels, Burtt Noël P, Mahajan Anubha, Fuchsberger Christian, Atzmon Gil, Benediktsson Rafn, Blangero John, Bowden Don W, Brandslund Ivan, Brosnan Julia, Burslem Frank, Chambers John, Cho Yoon Shin, Christensen Cramer, Douglas Desirée A, Duggirala Ravindranath et al. (including Laakso Markku). NATURE GENETICS 46 4: 357-363. 2014

A common functional regulatory variant at a type 2 diabetes locus upregulates ARAP1 expression in the pancreatic beta cell

Kulzer JR, Stitzel ML, Morken MA, Huyghe JR, Fuchsberger C, Kuusisto J, Laakso M, Boehnke M, Collins FS, Mohlke KL. AMERICAN JOURNAL OF HUMAN GENETICS 94 2: 186-197. 2014

Family history of type 2 diabetes increases the risk of both obesity and its complications: is type 2 diabetes a disease of inappropriate lipid storage?

Cederberg Henna, Stancakova Alena, Kuusisto Johanna, Laakso Markku, Smith Ulf. JOURNAL OF INTERNAL MEDICINE 277 5: 540-551. 2014

Leveraging cross-species transcription factor binding site patterns: from diabetes risk loci to disease mechanisms

Claussnitzer Melina, Dankel Simon N, Klocke Bernward, Grallert Harald, Glunk Viktoria, Berulava Tea, Lee Heekyoung, Oskolkov Nikolay, Fadista Joao, Ehlers Kerstin, Wahl Simone, Hoffmann Christoph, Qian Kun, Rönn Tina, Riess Helene, Müller-Nurasyid Martina, Bretschneider Nancy, Schroeder Timm, Skurk Thomas, Horsthemke Bernhard et al. (including Kuusisto Johanna, Laakso Markku). CELL 156 1-2: 343-358. 2014

Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity

Dimas Antigone S, Lagou Vasiliki, Barker Adam, Knowles Joshua W, Mägi Reedik, Hivert Marie-France, Benazzo Andrea, Rybin Denis, Jackson Anne U, Stringham Heather M, Song Ci, Fischer-Rosinsky Antje, Boesgaard Trine Wellöw, Grarup Niels, Abbasi Fahim A, Assimes Themistocles L, Hao Ke, Yang Xia, Lecoeur Cécile, Barroso Inês et al (including Kuusisto Johanna, Laakso Markku). DIABETES (NY) 63 6: 2158-2171. 2014

Markers of tissue-specific insulin resistance predict the worsening of hyperglycemia, incident type 2 diabetes and cardiovascular disease

Fízelóvá Maria, Cederberg Henna, Stancakova Alena, Jauhiainen Raimo, Vangipurapu Jagadish, Kuusisto Johanna, Laakso Markku. PLOS ONE [ONLINE] 9 10: e109772. 2014

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.

Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium, Asian Genetic Epidemiology Network Type 2 Diabetes (AGEN-T2D) Consortium, South Asian Type 2 Diabetes (SAT2D) Consortium, Mexican American Type 2 Diabetes (MAT2D) Consortium, Type 2 Diabetes Genetic Exploration by Nex-generation sequencing in multi-Ethnic Samples (T2D-GENES) Consortium, Mahajan A, Go MJ, Zhang W, Below JE, Gault. NATURE GENETICS 46 3: 234-244. 2014

Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations

Ganesh SK, Chasman D, Larson MG, Guo X, Verwoert G, Bis JC, Gu X, Smith AV, Yang ML, Zhang Y, Ehret G, Rose LM, Hwang SJ, Papanicolau GJ, Sijbrands EJ, Rice K, Eiriksdottir G, Pihur V, Ridker PM, Vasan RS (including Kuusisto J, Laakso M). AMERICAN JOURNAL OF HUMAN GENETICS 95 1: 49-65. 2014

Genome-wide association study identifies three novel loci for type 2 diabetes

Hara Kazuo, Fujita Hayato, Johnson Todd A, Yamauchi Toshimasa, Yasuda Kazuki, Horikoshi Momoko, Peng Chen, Hu Cheng, Ma Ronald CW, Imamura Minako, Iwata Minoru, Tsunoda Tatsuhiko, Morizono Takashi, Shojima Nobuhiro, So Wing Yee, Leung Ting Fan, Kwan Patrick, Zhang Rong, Wang Jie, Yu Weihui et al. (including Kuusisto Johanna, Laakso Markku). HUMAN MOLECULAR GENETICS 23 1: 239-246. 2014

Serum 25-Hydroxyvitamin D: A Predictor of Macrovascular and Microvascular Complications in Patients With Type 2 Diabetes

Herrmann Markus, Sullivan David R, Veillard Anne-Sophie, McCorquodale Thomas, Straub Isabella R, Scott Russell, Laakso Markku, Topliss Duncan, Jenkins Alicia J, Blankenberg Stefan, Burton Anthony, Keech Anthony C for the FIELD study investigators. DIABETES CARE 38 3: 521-528. 2014

Novel approach identifies SNPs in SLC2A10 and KCNK9 with evidence for parent-of-origin effect on body mass index

Hoggart Clive J, Venturini Giulia, Mangino Massimo, Gomez Felicia, Ascari Giulia, Zhao Jing Hua, Teumer Alexander, Winkler Thomas W, Tšernikova Natalia, Luan Jian'an, Mihailov Evelin, Ehret Georg B, Zhang Weihua, Lamparter David, Esko Tõnu, Macé Aurelian, Rüeger Sina, Bochud Pierre-Yves, Barcella Matteo, Dauvilliers Yves et al (including Atalay Mustafa, Kuusisto Johanna, Lakka Timo, Yaluri Alena, . PLOS GENETICS [ONLINE) 10 7: e1004508. 2014

A new common mutation in the cardiac beta-myosin heavy chain gene in Finnish patients with hypertrophic cardiomyopathy

Jääskeläinen Pertti, Heliö Tiina, Aalto-Setälä Katriina, Kaartinen Maija, Ilveskoski Erkki, Hämäläinen Liisa, Melin John, Kärkkäinen Satu, Peuhkurinen Keijo, Nieminen Markku S, Laakso Markku, the FinHCM MStudy Group, Kuusisto Johanna. Annals of Medicine 46: 424-429. 2014

The DEXLIFE study methods: Identifying novel candidate biomarkers that predict progression to type 2 diabetes in high risk individuals

Andersen GS, Thybo T, Cederberg H, Oresic M, Esteller M, Zorzano A, Carr B, Walker M, Cobb J, Clissmann C, O'Gorman DJ, Nolan JJ, on behalf of the DEXLIFE Consortium (including Laakso M). DIABETES RESEARCH AND CLINICAL PRACTICE 106 2: 383-389. 2014

Genetic Loci for Retinal Arteriolar Microcirculation

Sim X, Jensen RA, Ikram MK, Cotch MF, Li X, MacGregor S, Xie J, Smith AV, Boerwinkle E, Mitchell P, Klein R, Klein BE, Glazer NL, Lumley T, McKnight B, Psaty BM, de Jong PT, Hofman A, Rivadeneira F, Uitterlinden AG et al (including M Laakso, J Kuusisto). PLOS ONE [ONLINE] 8: e65804. 2013

Association of erythrocyte membrane fatty acids with changes in glycemia and risk of type 2 diabetes

Mahendran Y, Ågren J, Uusitupa M, Cederberg H, Vangipurapu J, Stancakova A, Schwab U, Kuusisto J, Laakso M. AMERICAN JOURNAL OF CLINICAL NUTRITION -: -. 2013

Glycerol and fatty acids in serum predict the development of hyperglycemia and type 2 diabetes in Finnish men

Mahendran Yuvaraj, Cederberg Henna, Vangipurapu Jagadish, Kangas Antti J, Soininen Pasi, Kuusisto Johanna, Uusitupa Matti, Ala-Korpela Mika, Laakso Markku. DIABETES CARE 36: 3732-3738. 2013

Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer

Patra KC, Wang Q, Bhaskar PT, Miller L, Wang Z, Wheaton W, Chandel N, Laakso M, Muller WJ, Allen EL, Jha AK, Smolen GA, Clasquin MF, Robey RB, Hay N. CANCER CELL 24: 213-228. 2013

The SH2B1 obesity locus and abnormal glucose homeostasis: lack of evidence for association from a meta-analysis in individuals of European ancestry

Prudente S, Copetti M, Morini E, Mendonca C, Andreozzi F, Chandalia M, Baratta R; DIAGRAM consortium (including Kuusisto J, Laakso M), Pellegrini F, Mercuri L, Bailetti D, Abate N, Frittitta L, Sesti G, Florez JC, Doria A, Trischitta V. NUTRITION, METABOLISM AND CARDIOVASCULAR DISEASES 23: 1043-1049. 2013

Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits

Randall JC, Winkler TW, Kutalik Z, Berndt SI, Jackson AU, Monda KL, Kilpeläinen TO, Esko T, Mägi R, Li S, Workalemahu T, Feitosa MF, Croteau-Chonka DC, Day FR, Fall T, Ferreira T, Gustafsson S, Locke AE, Mathieson I, Scherag A, et al. (including J Kuusisto, M Laakso, M Atalay, T Lakka). PLOS GENETICS [ONLINE) 9 6: e1003500. 2013

Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India.

Saxena R, Saleheen D, Been LF, Garavito ML, Braun T, Bjonnes A, Young R, Ho WK, Rasheed A, Frossard P, Sim X, Hassanali N, Radha V, Chidambaram M, Liju S, Rees SD, Ng DP, Wong TY, Yamauchi T, Hara K, et al. (including J Kuusisto, M Laakso). DIABETES (NY) 62 5: 1746-1755. 2013

Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus.

Scirica BM, Bhatt DL, Braunwald E, Steg PG, Davidson J, Hirshberg B, Ohman P, Frederich R, Wiviott SD, Hoffman EB, Cavender MA, Udell JA, Desai NR, Mosenzon O, McGuire DK, Ray KK, Leiter LA, Raz I; SAVOR-TIMI 53 Steering Committee and Investigators (including M Laakso). NEW ENGLAND JOURNAL OF MEDICINE 369: 1317-1326. 2013

A Mouse Model of Human Hyperinsulinism Produced by the E1506K Mutation in the Sulphonylurea Receptor SUR1

Shimomura K, Tusa M, Iberl M, Brereton MF, Kaizik S, Proks P, Lahmann C, Yaluri N, Modi S, Huopio H, Ustinov J, Otonkoski T, Laakso M, Ashcroft FM. DIABETES (NY) 62: 3797-3806. 2013

Trans-Ethnic Fine-Mapping of Lipid Loci Identifies Population-Specific Signals and Allelic Heterogeneity That Increases the Trait Variance Explained

Wu Y, Waite LL, Jackson AU, Sheu WH, Buyske S, Absher D, Arnett DK, Boerwinkle E, Bonnycastle LL, Carty CL, Cheng I, Cochran B, Croteau-Chonka DC, Dumitrescu L, Eaton CB, Franceschini N, Guo X, Henderson BE, Hindorff LA, Kim E, et al. (including Stancakova A, Kuusisto J, Laakso M, Uusitupa M, Rauramaa R Lakka T.). PLOS GENETICS [ONLINE) 9 3: e1003379. 2013

Desmosterol in human nonalcoholic steatohepatitis

Simonen M, Männistö V, Leppänen J, Kaminska D, Kärjä V, Venesmaa S, Käkelä P, Kuusisto J, Gylling H, Laakso M, Pihlajamäki J. HEPATOLOGY 58: 976-982. 2013

The Age-Specific Quantitative Effects of Metabolic Risk Factors on Cardiovascular Diseases and Diabetes: A Pooled Analysis

Singh GM, Danaei G, Farzadfar F, Stevens GA, Woodward M, Wormser D, Kaptoge S, Whitlock G, Qiao Q, Lewington S, Di Angelantonio E, Vander Hoorn S, Lawes CM, Ali MK, Mozaffarian D, Ezzati M, Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group, Asia-Pacific Cohort Studies Collaboration (APCSC), Diabetes Epidemiology: Collaborative analysis of Diagnostic criteria in Europ. PLOS ONE [ONLINE] 8 7: 1-10. 2013

Genome-wide association study for type 2 diabetes in Indians identifies a new susceptibility locus at 2q21

Tabassum R, Chauhan G, Dwivedi OP, Mahajan A, Jaiswal A, Kaur I, Bandesh K, Singh T, Mathai BJ, Pandey Y, Chidambaram M, Sharma A, Chavali S, Sengupta S, Ramakrishnan L, Venkatesh P, Aggarwal SK, Ghosh S, Prabhakaran D, Srinath RK, et al (including M Laakso, J Kuusisto). DIABETES (NY) 62 3: 977-986. 2013

Dietary fat in relation to erythrocyte fatty acid composition in men

Takkunen M, Ågren J, Kuusisto J, Laakso M, Uusitupa M, Schwab U. LIPIDS 48: 1093-1102. 2013

Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts

Vimaleswaran KS, Berry DJ, Lu C, Tikkanen E, Pilz S, Hiraki LT, Cooper JD, Dastani Z, Li R, Houston DK, Wood AR, Michaëlsson K, Vandenput L, Zgaga L, Yerges-Armstrong LM, McCarthy MI, Dupuis J, Kaakinen M, Kleber ME, Jameson K, et al. (including Laakso M, Kuusisto J). PLOS MEDICINE 10 2: e1001383. 2013

Discovery and refinement of loci associated with lipid levels

Willer CJ, Schmidt EM, Sengupta S, Peloso GM, Gustafsson S, Kanoni S, Ganna A, Chen J, Buchkovich ML, Mora S, Beckmann JS, Bragg-Gresham JL, Chang H-Y, Demirkan A, Den Hertog HM, Do R, Donnelly LA, Ehret GB, Esko T, Feitosa MF et.al.. NATURE GENETICS 45 11: 1274-1283. 2013

A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans.

Li H, Gan W, Lu L, Dong X, Han X, Hu C, Yang Z, Sun L, Bao W, Li P, He M, Sun L, Wang Y, Zhu J, Ning Q, Tang Y, Zhang R, Wen J, Wang D, Zhu X, et al. (including Kuusisto J, Laakso M). DIABETES (NY) 62 1: 291-298. 2013

Genetic Variants Associated With Glycine Metabolism and Their Role in Insulin Sensitivity and Type 2 Diabetes

Xie W, Wood AR, Lyssenko V, Weedon MN, Knowles JW, Alkayyali S, Assimes TL, Quertermous T, Abbasi F, Paananen J, Häring H, Hansen T, Pedersen O, Smith U, Laakso M; MAGIC Investigators; DIAGRAM Consortium; GENESIS Consortium; RISC Consortium, Dekker JM. DIABETES (NY) 62 6: 2141-2150. 2013

Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes.

Yaghootkar H, Lamina C, Scott RA, Dastani Z, Hivert M-F, Warren LL, Stancáková A, Buxbaum SG, Lyytikäinen L-P, Henneman P, Wu Y, Cheung CYY, Pankow JS, Jackson AU, Gustafsson S, Zhao JH, Ballantyne CM, Xie W, Bergman RN, Boehnke M et al. (including J Kuusisto, M Laakso, J Paananen). DIABETES (NY) 62: 3589-3598. 2013

Genetic screening for the risk of type 2 diabetes

Lyssenko V, Laakso M. DIABETES CARE 36 Supplement 2: S120-S126. 2013

Association of ketone body levels with hyperglycemia and type 2 diabetes in 9,398 Finnish men

Mahendran Y, Vangipurapu J, Cederberg H, Stancáková A, Pihlajamäki J, Soininen P, Kangas AJ, Paananen J, Civelek M, Saleem NK, Pajukanta P, Lusis AJ, Bonnycastle LL, Morken MA, Collins FS, Mohlke KL, Boehnke M, Ala-Korpela M, Kuusisto J, Laakso M. DIABETES (NY) 62: 3618-3626. 2013

Distinct metabolic and vascular effects of dietary triglycerides and cholesterol in atherosclerotic and diabetic mouse models

Laplante MA, Charbonneau A, Avramoglu RK, Pelletier P, Fang X, Bachelard H, Ylä-Herttuala S, Laakso M, Després JP, Deshaies Y, Sweeney G, Mathieu P, Marette A. AMERICAN JOURNAL OF PHYSIOLOGY. ENDOCRINOLOGY AND METABOLISM [PRINTED AND ONLINE: HTTP://AJPENDO.PHYSIOLOGY.ORG/] vol. 305 no. 5: E573-E584. 2013

Common variants associated with plasma triglycerides and risk for coronary artery disease

Do R, Willer CJ, Schmidt EM, Sengupta S, Gao C, Peloso GM, Gustafsson S, Kanoni S, Ganna A, Chen J, Buchkovich ML, Mora S, Beckmann JS, Bragg-Gresham JL, Chang H-Y, Demirkan A, Den Hertog HM, Donnelly LA, Ehret GB, Esko T et.al.. NATURE GENETICS 45 11: 1345-52. 2013

Link between GIP and osteopontin in adipose tissue and insulin resistance

Ahlqvist E, Osmark P, Kuulasmaa T, Pilgaard K, Omar B, Brøns C, Kotova O, Zetterqvist AV, Stancáková A, Jonsson A, Hansson O, Kuusisto J, Kieffer TJ, Tuomi T, Isomaa B, Madsbad S, Gomez MF, Poulsen P, Laakso M, Degerman E, et al. (including Pihlajamäki J). DIABETES (NY) 62 6: 2088-2094. 2013

Gene × Physical Activity Interactions in Obesity: Combined Analysis of 111,421 Individuals of European Ancestry

Ahmad S, Rukh G, Varga TV, Ali A, Kurbasic A, Shungin D, Ericson U, Koivula RW, Chu AY, Rose LM, Ganna A, Qi Q, Stančáková A, Sandholt CH, Elks CE, Curhan G, Jensen MK, Tamimi RM, Allin KH, Jørgensen T et al. (including Laakso M). PLOS GENETICS [ONLINE) 9 7: e1003607. 2013

Tunnistatko diabetestyypin?

Laakso M. YLEISLÄÄKÄRI 28: 9-12. 2013

The Genetic and Metabolic Determinants of Cardiovascular Complications in Type 2 Diabetes: Recent Insights from Animal Models and Clinical Investigations

Avramoglu RK, Laplante M-A, Quang KL, Deshaies Y, Despres J-P, Larose E, Mathieu P, Poirier P, Perusse L, Vohl M-C, Sweeney G, Ylä-Herttuala S, Laakso M, Uusitupa M, Marette A. Canadian Journal of Diabetes 37 5: 351-358. 2013

Influence of apolipoproteins on the association between lipids and insulin sensitivity: a cross-sectional analysis of the RISC Study.

Baldi S, Bonnet F, Laville M, Morgantini C, Monti L, Hojlund K, Ferrannini E, Natali A; RISC Investigators (including Laakso, M).. DIABETES CARE 36 12: 4125-4131. 2013

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

Berndt SI, Gustafsson S, Mägi R, Ganna A, Wheeler E, Feitosa MF, Justice AE, Monda KL, Croteau-Chonka DC, Day FR, Esko T, Fall T, Ferreira T, Gentilini D, Jackson AU, Luan J, Randall JC, Vedantam S, Willer CJ, Winkler TW, et al. (including Atalay M, Kuusisto J, Lakka TA, Stancakova A, Laakso M, Uusitupa M). NATURE GENETICS 45 5: 501-512. 2013

Autosomal Dominant Diabetes Arising From a Wolfram Syndrome 1 Mutation

Bonnycastle LL, Chines PS, Hara T, Huyghe JR, Swift AJ, Heikinheimo P, Mahadevan J, Peltonen S, Huopio H, Nuutila P, Narisu N, Goldfeder RL, Stitzel ML, Lu S, Boehnke M, Urano F, Collins FS, Laakso M. DIABETES (NY) 62: 3943-3950. 2013

Non-cholesterol sterol levels predict hyperglycemia and conversion to type 2 diabetes in finnish men

Cederberg H, Gylling H, Miettinen TA, Paananen J, Vangipurapu J, Pihlajamäki J, Kuulasmaa T, Stancáková A, Smith U, Kuusisto J, Laakso M. PLOS ONE [ONLINE] 8 6: e67406. 2013

Genetic regulation of human adipose microRNA expression and its consequences for metabolic traits

Civelek M, Hagopian R, Pan C, Che N, Yang WP, Kayne PS, Saleem NK, Cederberg H, Kuusisto J, Gargalovic PS, Kirchgessner TG, Laakso M, Lusis AJ.. HUMAN MOLECULAR GENETICS 22 15: 3023-3037. 2013

Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes

Albrechtsen A, Grarup N, Li Y, Sparsø T, Tian G, Cao H, Jiang T, Kim SY, Korneliussen T, Li Q, Nie C, Wu R, Skotte L, Morris AP, Ladenvall C, Cauchi S, Stančáková A, Andersen G, Astrup A, Banasik K, et al. (including Stancakova A, Kuusisto J, Laakso M). DIABETOLOGIA 56: 298-310. 2013

Mining the human phenome using allelic scores that index biological intermediates

Evans DM, Brion MJ, Paternoster L, Kemp JP, McMahon G, Munafò M, Whitfield JB, Medland SE, Montgomery GW; GIANT Consortium; CRP Consortium; TAG Consortium, Timpson NJ, St Pourcain B, Lawlor DA, Martin NG, Dehghan A, Hirschhorn J, Davey Smith G et al. (including M Laakso ja J Kuusisto). PLOS GENETICS [ONLINE) 9: e1003919. 2013

The Cancer-Associated FGFR4-G388R Polymorphism Enhances Pancreatic Insulin Secretion and Modifies the Risk of Diabetes

Ezzat S, Zheng L, Florez JC, Stefan N, Mayr T, Hliang MM, Jablonski K, Harden M, Stančáková A, Laakso M, Haring HU, Ullrich A, Asa SL. Cell Metabolism 17 6: 929-940. 2013

WISP2 regulates preadipocyte commitment and PPAR&#947 activation by BMP4

Hammarstedt A, Hedjazifar S, Jenndahl L, Gogg S, Grünberg J, Gustafson B, Klimcakova E, Stich V, Langin D, Laakso M, Smith U.. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 110 7: 2563-2568. 2013

Meta-analysis of gene-level associations for rare variants based on single-variant statistics

Hu Y-J, Berndt SI, Gustafsson S, Ganna A, Genetic Investigation of ANthropometric Traits (GIANT) Consortium (including M Atalay, T Lakka, J Kuusisto, M Laakso), Hirschhorn J, North KE, Ingelsson E, Lin D-Y et.al.. AMERICAN JOURNAL OF HUMAN GENETICS 93 2: 236-248. 2013

Association of risk variants for type 2 diabetes and hyperglycemia with gestational diabetes

Huopio H, Cederberg H, Vangipurapu J, Hakkarainen H, Pääkkönen M, Kuulasmaa T, Heinonen S, Laakso M. EUROPEAN JOURNAL OF ENDOCRINOLOGY 169 3: 291-297. 2013

Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion

Huyghe JR, Jackson AU, Fogarty MP, Buchkovich ML, Stancáková A, Stringham HM, Sim X, Yang L, Fuchsberger C, Cederberg H, Chines PS, Teslovich TM, Romm JM, Ling H, McMullen I, Ingersoll R, Pugh EW, Doheny KF, Neale BM, Daly MJ, et al (including J Kuusisto, M Laakso). NATURE GENETICS 45 2: 197-201. 2013

Two founder mutations in the alpha-tropomyosin and the cardiac myosin-binding protein C genes are common causes of hypertrophic cardiomyopathy in the Finnish population

Jääskeläinen P, Heliö T, Aalto-Setälä K, Kaartinen M, Ilveskoski E, Hämäläinen L, Melin J, Nieminen MS, Laakso M, Kuusisto J; FinHCM study group, Kervinen H, Mustonen J, Juvonen J, Niemi M, Uusimaa P, Huttunen M, Kotila M, Pietilä M.. Annals of Medicine 45: 85-90. 2013

Adipose tissue INSR splicing in humans associates with fasting insulin level and is regulated by weight loss

Kaminska D, Hämäläinen M, Cederberg H, Käkelä P, Venesmaa S, Miettinen P, Ilves I, Herzig KH, Kolehmainen M, Karhunen L, Kuusisto J, Gylling H, Laakso M, Pihlajamäki J. DIABETOLOGIA Epub 2013 Nov 7.: 1-5. 2013

Insulin sensitivity and carotid intima-media thickness: relationship between insulin sensitivity and cardiovascular risk study

Kozakova M, Natali A, Dekker J, Beck-Nielsen H, Laakso M, Nilsson P, Balkau B, Ferrannini E; RISC Investigators. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 33 6: 1409-1417. 2013

Update on type 2 diabetes as a cardiovascular disease risk equivalent

Kuusisto J, Laakso M. CURRENT CARDIOLOGY REPORTS 15: 331. 2013

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

Scott RA, Lagou V, Welch RP, Wheeler E, Montasser ME, Luan J, Mägi R, Strawbridge RJ, Rehnberg E, Gustafsson S, Kanoni S, Rasmussen-Torvik L, Yengo L, Lecoeur C, Shungin D, Sanna S, Sidore C, Johnson PCD, Jukema JW, Johnson T et.al.. NATURE GENETICS 44 9: 991-1005. 2012

No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels

Scott RA, Chu AY, Grarup N, ManningAK, Hivert M-F, Shungin D, Tönjes A, Yesupriya A, Barnes D, Bouatia-Naji N, Glazer NL, Jackson AU, Kutalik Z, Lagou V, Marek D, Rasmussen-Torvik LJ, Stringham HM, Tanaka T, Aadah M, Arking DE et.al.. DIABETES (NY) 61 5: 1291-1296. 2012

A genome-wide association search for type 2 diabetes genes in African Americans

Palmer ND, McDonough CW, Hicks PJ, Roh BH, Wing MR, An SS, Hester JM, Cooke JN, Bostrom MA, Rudock ME, Talbert ME, Lewis JP; DIAGRAM Consortium; MAGIC Investigators, Ferrara A, Lu L, Ziegler JT, Sale MM, Divers J, Shriner D et.al.. PLOS ONE [ONLINE] 7 1: e29202. 2012

Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies

Sarwar N, Butterworth AS, Freitag DF, Gregson J, Willeit P, Gorman DN, Gao P, Saleheen D, Rendon A, Nelson CP, Braund PS, Hall AS, Chasman DI, Tybjaerg-Hansen A, Chambers JC, Benjamin EJ, Franks PW, Clarke R, Wilde AAM, Trip MD et.al.. LANCET 379 9822: 1205-1213. 2012

Response to Brosch et al.

Pihlajamäki J, Lerin C, Kaminska D, Venesmaa S, Itkonen P, Boes T, Floss T, Schroeder J, Dearie F, Crunkhorn S, Burak F, Jimenez-Chillaron JC, Kuulasmaa T, Miettinen P, Park PJ, Nasser I, Zhao Z, Zhang Z, Xu Y, Wurst W et.al.. Cell Metabolism 15 3: 267-269. 2012

Serum interleukin 1 receptor antagonist as anindependent marker of non-alcoholic steatohepatitis in humans

Pihlajamäki J, Kuulasmaa T, Kaminska D, Simonen M, Kärjä V, Grönlund S, Käkelä P, Pääkkönen M, Kainulainen S, Punnonen K, Kuusisto J, Gylling H, Laakso M. JOURNAL OF HEPATOLOGY 56 3: 663-670. 2012

Reduced hexokinase II impairs muscle function 2 wk after ischemia-reperfusion through increased cell necrosis and fibrosis

Smeele KM, Eerbeek O, Schaart G, Koeman A, Bezemer R, Nelson JK, Ince C, Nederlof R, Boek M, Laakso M, de Haan A, Drost MR, Hollmann MW, Zuurbier CJ. JOURNAL OF APPLIED PHYSIOLOGY 113: 608-618. 2012

Conjugated Bile Acids Associate with Altered Rates of Glucose and Lipid Oxidation after Roux-en-Y Gastric Bypass

Simonen M, Dali-Youcef N, Kaminska D, Venesmaa S, Käkelä P, Pääkkönen M, Hallikainen M, Kolehmainen M, Uusitupa M, Moilanen L, Laakso M, Gylling H, Patti ME, Auwerx J, Pihlajamäki J. OBESITY SURGERY 22 9: 1473-1480. 2012

Proteinuria modifies the effect of systolic blood pressure on total and cardiovascular disease mortality in patients with type 2 diabetes.

Vepsäläinen T, Laakso M, Kantola I, Lehto S, Juutilainen A, Rönnemaa T. JOURNAL OF INTERNAL MEDICINE 272 6: 611-619. 2012

Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis

Stahl EA, Wegmann D, Trynka G, Gutierrez-Achury J, Do R, Voight BF, Kraft P, Chen R, Kallberg HJ, Kurreeman FA; Diabetes Genetics Replication and Meta-analysis Consortium; Myocardial Infarction Genetics Consortium, Kathiresan S, Wijmenga C, Gregersen PK, Alfredsson L, Siminovitch KA, Worthington J, de Bakker PI, Raychaudhuri S, Plenge RM. NATURE GENETICS 44: 483-489. 2012

Hyperglycemia and a common variant of GCKR are associated with the levels of eight amino acids in 9,369 Finnish men

Stancáková Alena, Civelek Mete, Saleem Niyas K, Soininen Pasi, Kangas Antti J, Cederberg Henna, Paananen Jussi, Pihlajamäki Jussi, Bonnycastle Lori L, Morken Mario A, Boehnke Michael, Pajukanta Päivi, Lusis Aldons J, Collins Francis S, Kuusisto Johanna, Ala-Korpela Mika, Laakso Markku. DIABETES (NY) 61: 1895-1902. 2012

Large-scale association analysis identifies new risk loci for coronary artery disease

The CARDIoGRAMplusC4D Consortium (including M Laakso, J Kuusisto), Deloukas P, Kanoni S, Willenborg C, Farrall M, Assimes TL, Thompson JR, Ingelsson E, Saleheen D, Erdmann J, Goldstein BA, Stirrups K, König IR, Cazier JB, Johansson A, Hall AS, Lee JY, Willer CJ, Chambers JC, Esko T et al. NATURE GENETICS 45 1: 25-33. 2012

Benefits and safety of long-term fenofibrate therapy in people with type 2 diabetes and renal impairment: the FIELD Study

Ting RD, Keech AC, Drury PL, Donoghoe MW, Hedley J, Jenkins AJ, Davis TM, Lehto S, Celermajer D, Simes RJ, Rajamani K, Stanton K; FIELD Study Investigators. DIABETES CARE 35: 218-225. 2012

Association between liver insulin resistance and cardiovascular risk factors

Vangipurapu Jagadish, Stančáková A, Kuulasmaa Teemu, Soininen Pasi, Kangas AJ, Ala-Korpela Mika, Kuusisto Johanna, Laakso Markku. JOURNAL OF INTERNAL MEDICINE 272: 402-408. 2012

Lipoprotein subclass profiles in individuals with varying degrees of glucose tolerance: a population-based study of 9399 Finnish men

Wang J, Stančáková A, Soininen P, Kangas AJ, Paananen J, Kuusisto J, Ala-Korpela M, Laakso M. JOURNAL OF INTERNAL MEDICINE 272: 562-572. 2012

Hexokinase II knockdown results in exaggerated cardiac hypertrophy via increased ROS production

Wu R, Wyatt E, Chawla K, Tran M, Ghanefar M, Laakso M, Epting CL, Ardehali H. EMBO molecular medicine (Print) 4: 633-646. 2012

Circulating Metabolite Predictors of Glycemia in Middle-Aged Men and Women

Würtz Peter, Tiainen Mika, Mäkinen Ville-Petteri, Kangas Antti, Soininen Pasi, Saltevo Juha, Keinänen-Kiukaanniemi Sirkka, Mäntyselkä Pekka, Lehtimäki Terho, Laakso Markku, Jula Antti, Kähönen Mika, Vanhala Mauno, Ala-Korpela Mika. DIABETES CARE 35: 1749-1756. 2012

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

Morris AP, Voight BF, Teslovich TM, Ferreira T, Segrè AV, Steinthorsdottir V, Strawbridge RJ, Khan H, Grallert H, Mahajan A, Prokopenko I, Kang HM, Dina C, Esko T, Fraser RM, Kanoni S, Kumar A, Lagou V, Langenberg C, Luan J et.al.. NATURE GENETICS 44 9: 981-990. 2012

Serine/threonine protein kinase 25(STK25): a novel negative regulator of lipid and glucose metabolism in rodent and human skeletal muscle

Nerstedt A, Cansby E, Andersson CX, Laakso M, Stancakova A, Blüher M, Smith U, Mahlapuu M. DIABETOLOGIA 55 6: 1797-1807. 2012

Purchase of antidepressant agents by patients with type 1 diabetes is associated with increased mortality rates in women but not in men

Ahola AJ, Harjutsalo V, Saraheimo M, Forsblom C, Groop PH; FinnDiane Study Group.. DIABETOLOGIA 55 1: 73-79. 2012

Low-frequency variants in HMGA1 are not associated with type 2 diabetes risk

Marquez M, Huyvaert M, Perry JR, Pearson RD, Falchi M, Morris AP, Vivequin S, Lobbens S, Yengo L, Gaget S, Pattou F, Poulain-Godefroy O, Charpentier G, Carlsson LM, Jacobson P, Sjöström L, Lantieri O, Heude B, Walley A, Balkau B, Marre M, Froguel P, Cauchi S; DIAGRAM Consortium. DIABETES (NY) 61 2: 524-530. 2012

From metabolic normality to cardiometabolic risk factors in subjects with obesity.

Heine RJ, Dekker J, Nijpels G, Boorsma W, Mitrakou A, Tournis S, Kyriakopoulou K, Thomakos P, Lalic N, Lalic K, Jotic A, Lukic L, Civcic M, Nolan J, Yeow TP, Murphy M, DeLong C, Neary G, Colgan MP, Hatunic M, et al. (inclunding Laakso). OBESITY (SILVER SPRING, MD.) 20 10: 2063-2069. 2012

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

Manning AK, Hivert MF, Scott RA, Grimsby JL, Bouatia-Naji N, Chen H, Rybin D, Liu CT, Bielak LF, Prokopenko I, Amin N, Barnes D, Cadby G, Hottenga JJ, Ingelsson E, Jackson AU, Johnson T, Kanoni S, Ladenvall C, Lagou V et.al.. NATURE GENETICS 44 6: 659-669. 2012

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.

Dastani Z, Hivert MF, Timpson N, Perry JR, Yuan X, Scott RA, Henneman P, Heid IM, Kizer JR, Lyytikäinen LP, Fuchsberger C, Tanaka T, Morris AP, Small K, Isaacs A, Beekman M, Coassin S, Lohman K, Qi L, Kanoni S et.al.. PLOS GENETICS [ONLINE) 8 3: e1002607. 2012

Insulin secretion and its determinants in the progression of impaired glucose tolerance to type 2 diabetes in impaired glucose-tolerant individuals: the finnish diabetes prevention study

de Mello Laaksonen VD, Lindström J, Eriksson J, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Sundvall J, Laakso M, Tuomilehto J, Uusitupa M. DIABETES CARE 35: 211-217. 2012

Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations

Demirkan A, van Duijn CM, Ugocsai P, Isaacs A, Pramstaller PP, Liebisch G, Wilson JF, Johansson Å, Rudan I, Aulchenko YS, Kirichenko AV, Janssens AC, Jansen RC, Gnewuch C, Domingues FS, Pattaro C, Wild SH, Jonasson I, Polasek O, Zorkoltseva IV et.al.. PLOS GENETICS [ONLINE) 8 2: e1002490. 2012

Long-term effects of placental growth on overweight and body composition

Eriksson JG, Gelow J, Thornburg KL, Osmond C, Laakso M, Uusitupa M, Lindi V, Kajatie E, Barker DJP. International journal of pediatrics 2012 2012:324185 Epub 2012 Apr 18.: 6 pages. 2012

Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women

Fox CS, Liu Y, White CC, Feitosa M, Smith AV, Heard-Costa N, Lohman K; GIANT Consortium; MAGIC Consortium; GLGC Consortium, Johnson AD, Foster MC, Greenawalt DM, Griffin P, Ding J, Newman AB, Tylavsky F, Miljkovic I, Kritchevsky SB, Launer L et.al.. PLOS GENETICS [ONLINE) 8 5: e1002695. 2012

Plasma sCD36 is associated with markers of atherosclerosis, insulin resistance and fatty liver in a nondiabetic healthy population

Handberg A, Højlund K, Gastaldelli A, Flyvbjerg A, Dekker JM, Petrie J, Piatti P, Beck-Nielsen H; RISC Investigators. JOURNAL OF INTERNAL MEDICINE 271 3: 294-304. 2012

Adipose Co-expression networks across Finns and Mexicans identify novel triglyceride-associated genes

Haas BE, Horvath S, Pietiläinen KH, Cantor RM, Nikkola E, Weissglas-Volkov D, Rissanen A, Civelek M, Cruz-Bautista I, Riba L, Kuusisto J, Kaprio J, Tusie-Luna T, Laakso , Aguilar-Salinas CA, Pajukanta P. BMC Medical Genomics 5: 61. 2012

Contribution of genetic and dietary insulin resistance to Alzheimer phenotype in APP/PS1 transgenic mice

Hiltunen M, Khandelwal VKM, Yaluri N, Tiilikainen T, Tusa M, Koivisto H, Krzisch M, Vepsäläinen S, Mäkinen P, Kemppainen S, Miettinen P, Haapasalo A, Soininen H, Laakso M, Tanila H. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 16: 1206-1222. 2012

Fatty liver index, gamma-glutamyltransferase, and early carotid plaques

Kozakova M, Palombo C, Eng MP, Dekker J, Flyvbjerg A, Mitrakou A, Gastaldelli A, Ferrannini E; RISC Investigators.. HEPATOLOGY 55 5: 1406-1415. 2012

Glucose control in diabetes: which target level to aim for?

Laakso M, Cederberg H. JOURNAL OF INTERNAL MEDICINE 272: 1-12. 2012

A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations.

Imamura M, Maeda S, Yamauchi T, Hara K, Yasuda K, Morizono T, Takahashi A, Horikoshi M, Nakamura M, Fujita H, Tsunoda T, Kubo M, Watada H, Maegawa H, Okada-Iwabu M, Iwabu M, Shojima N, Ohshige T, Omori S, Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium (including M Laakso, J Kuusisto). HUMAN MOLECULAR GENETICS 21: 3042-3049. 2012

Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits

Kristiansson Kati, Perola Markus, Tikkanen Emmi, Kettunen Johannes, Surakka Ida, Havulinna Aki S, Stancáková Alena, Barnes Chris, Widen Elisabeth, Kajantie Eero, Eriksson Johan G, Viikari Jorma, Kähönen Mika, Lehtimäki Terho, Raitakari Olli T, Hartikainen Anna-Liisa, Ruokonen Aimo, Pouta Anneli, Jula Antti, Kangas Antti J et al. Circulation: Cardiovascular Genetics 5: 242-249. 2012

Low-grade inflammation and the phenotypic expression of myocardial fibrosis in hypertrophic cardiomyopathy

Kuusisto J, Kärjä V, Sipola P, Kholová I, Peuhkurinen K, Jääskeläinen P, Naukkarinen A, Ylä-Herttuala S, Punnonen K, Laakso M. HEART 98 13: 1007-1013. 2012

The activation of hepatic and muscle polyamine catabolism improves glucose homeostasis

Koponen T, Cerrada-Gimenez M, Pirinen E, Hohtola E, Paananen J, Vuohelainen S, Tusa M, Pirnes-Karhu S, Heikkinen S, Virkamäki A, Uimari A, Alhonen L, Laakso M.. AMINO ACIDS 42: 427-440. 2012

Circadian gene variants and susceptibility to type 2 diabetes: a pilot study

Kelly MA, Rees SD, Hydrie MZI, Shera AS, Bellary S, O¿Hare JP, Kumar S, Taheri S, Basit A, Barnett AH, DIAGRAM consortium, SAT2D consortium. PLOS ONE [ONLINE] 7 4: e32670. 2012

Adipose Tissue TCF7L2 Splicing Is Regulated by Weight Loss and Associates With Glucose and Fatty Acid Metabolism

Kaminska D, Kuulasmaa T, Venesmaa S, Käkelä P, Vaittinen M, Pulkkinen L, Pääkkönen M, Gylling H, Laakso M, Pihlajamäki J. DIABETES (NY) 61: 2807-2813. 2012

Disruption of hexokinase II-mitochondrial binding blocks ischemic preconditioning and causes rapid cardiac necrosis

Smeele KM, Southworth R, Wu R, Xie C, Nederlof R, Warley A, Nelson JK, van Horssen P, van den Wijngaard JP, Heikkinen S, Laakso M, Koeman A, Siebes M, Eerbeek O, Akar FG, Ardehali H, Hollmann MW, Zuurbier CJ. CIRCULATION RESEARCH 108: 1165-1169. 2011

Onko diabeteksen geenidiagnostiikasta hyötyä potilastyössä?

Laakso M. SUOMEN LÄÄKÄRILEHTI 66 1-2: 37-42. 2011

The Adipocyte-expressed forkhead transcription factor foxc2 regulates metabolism through altered mitochondrial function

Lidell ME, Seifert EL, Westergren R, Heglind M, Gowing A, Sukonina V, Arani Z, Itkonen P, Wallin S, Westberg F, et al.. DIABETES (NY) 60: 427-435. 2011

Pleiotropic Effects of GIP on Islet Function Involves Osteopontin

Lyssenko V, Eliasson L, Kotova O, Pilgaard K, Wierup N, Salehi A, Wendt A, Jonsson A, De Marinis YZ, Berglund LM, Taneera J, Balhuizen A, Hansson O, Osmark P, Dunér P, Brøns C, Stancáková A, Kuusisto J, Bugliani M, Saxena R, et al.. DIABETES (NY) 60: 2424-2433. 2011

Influence of hyperinsulinemia and insulin resistance on in vivo &#946 -cell function: their role in human &#946 -cell dysfunction.

Mari A, Tura A, Natali A, Anderwald C, Balkau B, Lalic N, Walker M, Ferrannini E, for the RISC Investigators (including Laakso M). 2011. Influence of hyperinsulinemia and insulin resistance on in vivo β-cell function: their role in human β-cell dysfunction. DIABETES (NY) 60: 3141- 2011

Serum interleukin 1 receptor antagonist as an independent marker of non-alcoholic steatohepatitis in humans

Pihlajamäki J, Kuulasmaa T, Kaminska D, Simonen M, Kärjä V, Grönlund S, Käkelä P, Pääkkönen M, Kainulainen S, Punnonen K, Kuusisto J, Gylling H, Laakso M. JOURNAL OF HEPATOLOGY 56 3: 663-670. 2011

Expression of the Splicing Factor Gene SFRS10 Is Reduced in Human Obesity and Contributes to Enhanced Lipogenesis

Pihlajamäki Jussi, Lerin Carles, Itkonen Paula, Boes Tanner, Thomas Floss Thomas, Schroeder Joshua, Dearie Farrell, Crunkhorn Sarah, Burak Furkan, Jimenez-Chillaron Josep C., Kuulasmaa Tiina, Miettinen Pekka, Park Peter J., Nasser Imad, Zhao Zhenwen, Zhang Zhaiyi, Xu Yan, Wurst Wolfgang, Ren Hongmei, Morris Andrew J.Stamm Stefan, Goldfine Allison B., Laakso Markku, Patti Mary Elizabeth. Cell Metabolism 14 2: 208-218. 2011

Fine mapping of five loci associated with low-density lipoprotein cholesterol detects variants that double the explained heritability

Sanna S, Li B, Mulas A, Sidore C, Kang HM, Jackson AU, Grazia Piras M, Usala G, Maninchedda G, Sassu A, Serra F, Palmas MA, Wood III WH, Njølstad I, Laakso M, Hveem K, Tuomilehto J, Lakka TA, Rauramaa R, Boehnke M,et al.. PLOS GENETICS [ONLINE) 7: e1002198. 2011

The Lin28/let-7 axis regulates glucose metabolism

Zhu H, Shyh-Chang N, Segrè AV, Shinoda G, Shah SP, Einhorn WS, Takeuchi A, Engreitz JM, Hagan JP, Kharas MG, Urbach A, Thornton JE, Triboulet R, Gregory RI; DIAGRAM Consortium; MAGIC Investigators, Altshuler D, Daley GQ. CELL 147 1: 81-94. 2011

The effect of standard chow and reduced hexokinase II on growth, cardiac and skeletal muscle hexokinase and low-flow cardiac ischaemia-reperfusion injury

Smeele KM, Ter Horst LH, Koeman A, Heikkinen S, Laakso M, Weber NC, Hollmann MW, Zuurbier CJ. LABORATORY ANIMALS 45: 160-166. 2011

Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits

Speliotes EK, Yerges-Armstrong LM, Wu J, Hernaez R, Kim LJ, Palmer CD, Gudnason V, Eiriksdottir G, Garcia ME, Launer LJ, Nalls MA, Clark JM, Mitchell BD, Shuldiner AR, Butler JL, Tomas M, Hoffmann U, Hwang SJ, Massaro JM, O'Donnell CJ, Sahani DV, Salomaa V, Schadt EE, Schwartz SM, Siscovick DS; NASH CRN; GIANT Consortium; MAGIC Investigators (including M. Laakso), Voight BF, Carr JJ, Feitosa MF, H. PLOS GENETICS [ONLINE) 7 3: e1001324. 2011

Effects of 34 Risk loci for type 2 diabetes or hyperglycemia on lipoprotein subclasses and their composition in 6,580 nondiabetic Finnish men

Stancáková A, Paananen J, Soininen P, Kangas AJ, Bonnycastle LL, Morken MA, Collins FS, Jackson AU, Boehnke ML, Kuusisto J, Ala-Korpela M, Laakso M. DIABETES (NY) 60: 1608-1616. 2011

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes

Strawbridge RJ, Dupuis J, Prokopenko I, Barker A, Ahlqvist E, Rybin D, Petrie JR, Travers ME, Bouatia-Naji N, Dimas AS, Nica A, Wheeler E, Chen H, Voight BF, Taneera J, Kanoni S, Peden JF, Turrini F, Gustafsson S, Zabena C, et al. DIABETES (NY) 60: 2624-2534. 2011

Impact of positive family history and genetic risk variants on the incidence of diabetes - the Finnish Diabetes Prevention Study

Uusitupa MI, Stancáková A, Peltonen M, Eriksson JG, Lindström J, Aunola S, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Laakso M. DIABETES CARE Online January 2011: 1-6. 2011

A novel surrogate index for hepatic insulin resistance

Vangipurapu J, Stancakova A, Kuulasmaa T, Paananen J, Kuusisto J, EGIR-RISC Study Group, Ferrannini E, Laakso M. DIABETOLOGIA 54: 540-543. 2011

Association of indices of liver and adipocyte insulin resistance with 19 confirmed susceptibility loci for type 2 diabetes in 6,733 non-diabetic Finnish men

Vangipurapu J, Stancakova A, Pihlajamäki J, Kuulasmaa TM, Kuulasmaa T, Paananen J, Kuusisto J, Ferrannini E, Laakso M. DIABETOLOGIA 54: 563-571. 2011

Physical activity, high-sensitivity C-reactive protein, and total and cardiovascular disease mortality in type 2 diabetes

Vepsäläinen T, Soinio M, Marniemi J, Lehto S, Juutilainen A, Laakso M, Rönnemaa T. DIABETES CARE 34: 1492-1496. 2011

Novel Susceptibility Locus at 22q11 for Diabetic Nephropathy in Type 1 Diabetes

Wessman M, Forsblom C, Kaunisto M, Söderlund J, Ilonen J, Sallinen R, Hiekkalinna T, Parkkonen M, Maxwell A, Tarnow L et.al.. PLOS ONE [ONLINE] 6: 1-9. 2011

Heart in diabetes: a microvascular disease

Laakso M. DIABETES CARE 34 Suppl 2: S145-S149. 2011

A Common Variant in TFB1M Is Associated with Reduced Insulin Secretion and Increased Future Risk of Type 2 Diabetes

Koeck T, Olsson AH, Nitert MD, Sharoyko VV, Ladenvall C, Kotova O, Reiling E, Rönn T, Parikh H, Taneera J, Eriksson JG, Metodiev MD, Larsson NG, Balhuizen A, Luthman H, Stančáková A, Kuusisto J, Laakso M, Poulsen P, Vaag A. Cell Metabolism 13: 80-91. 2011

Physical activity attenuates the influence of FTO variants on obesity risk: A meta-analysis of 218,166 adults and 19,268 children

Kilpeläinen Tuomas O, Qi Lu, Brage Soren, Sharp Stephen J., Sonestedt Emily, Demerath Ellen, Ahmad Tariq, Mora Samia, Kaakinen Marika, Sandholt Camilla H, Holzapfel Christina, Autenrieth Christine S., Hyppönen Elina, Cauchi Stéphane , He Meian, Kutalik Zoltan, Kumari Meena, Stancaková Alena, Meidtner Karina, Balkau Beverley et al.. PLOS MEDICINE 8 11: e1001116. 2011

Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study.

Fox ER, Young JH, Li Y, Dreisbach AW, Keating BJ, Musani SK, Liu K, Morrison AC, Ganesh S, Kutlar A, Ramachandran VS, Polak JF, Fabsitz RR, Dries DL, Farlow DN, Redline S, Adeyemo A, Hirschorn JN, Sun YV, Wyatt SB, Penman AD, Palmas W, Rotter JI, Townsend RR, Doumatey AP, Tayo BO, Mosley TH Jr, Lyon HN, Kang SJ, Rotimi CN, Cooper RS, Franceschini N, Curb JD, Martin LW, Eaton CB, Kardia SL, Taylor . HUMAN MOLECULAR GENETICS 20: 2273-2284. 2011

Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile

Kilpeläinen TO, Zillikens MC, Stančáková A, Finucane FM, Ried JS, Langenberg C, Zhang W, Beckmann JS, Luan J, Vandenput L, Styrkarsdottir U, Zhou Y, Smith AV, Zhao JH, Amin N, Vedantam S, Shin SY, Haritunians T, Fu M, Feitosa MF, Kumari M et al.. NATURE GENETICS 43: 753-760. 2011

Exercise during military training improves cardiovascular risk factors in young men

Cederberg H, Mikkola I, Jokelainen J, Laakso M, Härkönen P, Ikäheimo T, Laakso M, Keinänen-Kiukaanniemi S. ATHEROSCLEROSIS 216: 489-495. 2011

Unacylated ghrelin is associated with changes in body composition and body fat distribution during a long-term exercise intervention

Cederberg H, Rajala U, Koivisto VM, Jokelainen J, Surcel HM, Keinänen-Kiukaanniemi S, Laakso M. EUROPEAN JOURNAL OF ENDOCRINOLOGY 165: 243-248. 2011

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

Chambers John C, Zhang Weihua, Sehmi Joban, Li Xinzhong, Wass Mark N, Van der Harst Pim, Holm Hilma, Sanna Serena, Kavousi Maryam, Baumeister Sebastian E, Coin Lachlan J, Deng Guohong, Gieger Christian, Heard-Costa Nancy L, Hottenga Jouke-Jan, Kühnel Brigitte, Kumar Vinod, Lagou Vasiliki, Liang Liming, Luan Jian'an et.al.. NATURE GENETICS 43 11: 1131-1138. 2011

Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.

Cho YS, Chen CH, Hu C, Long J, Ong RT, Sim X, Takeuchi F, Wu Y, Go MJ, Yamauchi T, Chang YC, Kwak SH, Ma RC, Yamamoto K, Adair LS, Aung T, Cai Q, Chang LC, Chen YT,... Kuusisto J, Laakso M. NATURE GENETICS 44 1: 67-72. 2011

High-density lipoprotein-cholesterol and not HbA1c was directly related to cardiovascular outcome in PROactive

Ferrannini E, Betteridge DJ, Dormandy JA, Charbonnel B, Wilcox RG, Spanheimer R, Erdmann E, DeFronzo RA, Laakso M. DIABETES, OBESITY AND METABOLISM 13: 759-764. 2011

Natural history and physiological determinants of changes in glucose tolerance in a non-diabetic population: the RISC Study

Ferrannini E, Natali A, Muscelli E, Nilsson PM, Golay A, Laakso M, Beck-Nielsen H, Mari A; on behalf of the RISC Investigators. DIABETOLOGIA 54: 1507-1516. 2011

The Birth Weight Lowering C-Allele of rs900400 Near LEKR1 and CCNL1 Associates with Elevated Insulin Release following an Oral Glucose Challenge

Andersson EA, Harder MN, Pilgaard K, Pisinger C, Stančáková A, Kuusisto J, Grarup N, Færch K, Poulsen P, Witte DR, Jørgensen T, Vaag A, Laakso M, Pedersen O, Hansen T. PLOS ONE [ONLINE] 6: e27096. 2011

Evidence of how rs7575840 influences apolipoprotein B-containing lipid particles

Haas BE, Weissglas-Volkov D, Aguilar-Salinas CA, Nikkola E, Vergnes L, Cruz-Bautista I, Riba L, Stancakova A, Kuusisto J, Soininen P, Kangas AJ, Ala-Korpela M, Tusie-Luna T, Laakso M, Pajukanta P. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 31: 1201-1207. 2011

Plant stanol esters lower LDL cholesterol level in statin-treated subjects with type 1 diabetes by interfering the absorption and synthesis of cholesterol

Hallikainen Maarit, Kurl Sudhir, Laakso Markku, Miettinen Tatu A, Gylling Helena. ATHEROSCLEROSIS 217: 473-478. 2011

Left ventricular dysfunction with reduced functional cardiac reserve in diabetic and non-diabetic LDL-receptor deficient apolipoprotein B100-only mice

Heinonen Suvi E, Merentie Mari, Hedman Marja, Mäkinen Petri I, Loponen Elina, Kholová Ivana, Bosch Fatima, Laakso Markku, Ylä-Herttuala Seppo. CARDIOVASCULAR DIABETOLOGY [ONLINE: HTTP://WWW.CARDIAB.COM/] 10: 1-12. 2011

SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome

Hirschey MD, Shimazu T, Jing E, Grueter CA, Collins AM, Aouizerat B, Stančáková A, Goetzman E, Lam MM, Schwer B, Stevens RD, Muehlbauer MJ, Kakar S, Bass NM, Kuusisto J, Laakso M, Alt FW, Newgard CB, Farese RV Jr, Kahn CR, et al.. MOLECULAR CELL 44: 177-190. 2011

Glucose tolerance, insulin sensitivity and insulin release in European non-diabetic carriers of a polymorphism upstream of CDKN2A and CDKN2B

Hribal ML, Presta I, Procopio T, Marini MA, Stančáková A, Kuusisto J, Andreozzi F, Hammarstedt A, Jansson PA, Grarup N, Hansen T, Walker M, Stefan N, Fritsche A, Häring HU, Pedersen O, Smith U, Laakso M, Sesti G; on behalf of the EUGENE2 Consortium. DIABETOLOGIA 54: 795-802. 2011

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

International Consortium for Blood Pressure Genome-Wide Association Studies, Ehret GB, Munroe PB, Rice KM, Bochud M, Johnson AD, Chasman DI, Smith AV, Tobin MD, Verwoert GC, Hwang SJ, Pihur V, Vollenweider P, O'Reilly PF, Amin N, Bragg-Gresham JL, Teumer A, Glazer NL, Launer L, Zhao JH et. al.. NATURE (LONDON) 478 7367: 103-109. 2011

A role for coding functional variants in HNF4A in type 2 diabetes susceptibility

Jafar-Mohammadi B, Groves CJ, Gjesing AP, Herrera BM, Winckler W, Stringham HM, Morris AP, Lauritzen T, Doney ASF, Morris AD, Weedon MN, Swift AJ, Kuusisto J, Laakso M, Altshuler D, Hattersley AT, Collins FS, Boehnke M, Hansen T, Pedersen O, Palmer CNA, Frayling TM, DIAGRAM Consortium, Gloyn AL, McCarthy MI. DIABETOLOGIA 54: 111-119. 2011

Blood pressure loci identified with a gene-centric array

Johnson T, Gaunt TR, Newhouse SJ, Padmanabhan S, Tomaszewski M, Kumari M, Morris RW, Tzoulaki I, O'Brien ET, Poulter NR, Sever P, Shields DC, Thom S, Wannamethee SG, Whincup PH, Brown MJ, Connell JM, Dobson RJ, Howard PJ,...BPgen Consortium (including M Laakso). AMERICAN JOURNAL OF HUMAN GENETICS 89: 688-700. 2011

Äidin ja vastasyntyneen diabetes - pistoksista pillereihin

Kaunisto K, Ojaniemi M, Juuti A-K, Huopio H, Laakso M, Veijola R. DUODECIM 127: 61-64. 2011

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

Saxena R, Hivert MF, Langenberg C, Tanaka T, Pankow JS, Vollenweider P, Lyssenko V, Bouatia-Naji N, Dupuis J, Jackson AU, Kao WH, Li M, Glazer NL, Manning AK, Luan J, Stringham HM, Prokopenko I, Johnson T, Grarup N, Boesgaard TW et al.. NATURE GENETICS 42: 142-148. 2010

Genetic variation in gastric inhibitory polypeptide receptor (GIPR): Impacts the glucose and insulin responses to an oral glucose challenge

Saxena R, Hivert MF, Langenberg C, Tanaka T, Pankow JS, Vollenweider P, Lyssenko V, Bouatia-Naji N, .., Kuusisto J, Laakso M, et al.. NATURE GENETICS 42: 142-148. 2010

Genetic evidence that raised Sex Hormone Binding Globulin (SHBG) levels reduce the risk of type 2 diabetes

Perry JR, Weedon MN, Langenberg C, Jackson AU, Lyssenko V, Sparsø T, Thorleifsson G, ..., Kuusisto J, ..., Laakso M, et al. HUMAN MOLECULAR GENETICS 19: 535-544. 2010

SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity

Rutanen J, Yaluri N, Modi S, Pihlajamäki J, Vänttinen M, Itkonen P, Kainulainen S, Yamamoto H, Lagouge M, ..., Laakso M. DIABETES (NY) 59: 829-835. 2010

Changes in cytokine levels during acute hyperinsulinemia in offspring of type 2 diabetic subjects

Ruotsalainen E, Stancakova A, Vauhkonen I, Salmenniemi U, Pihlajamäki J, Punnonen K, Laakso M. ATHEROSCLEROSIS 210: 536-541. 2010

Activated polyamine catabolism leads to low cholesterol levels by enhancing bile acid synthesis

Pirinen E, Gylling H, Itkonen P, Yaluri N, Heikkinen S, Pietilä M, Kuulasmaa T, Tusa M, Cerrada-Gimenez M, Pihlajamäki J, Alhonen L, Jänne J, Miettinen TA & Laakso M. AMINO ACIDS 38: 549-560. 2010

Common variants at ten genomic loci influence hemoglobin A1C levels via glycemic and non-glycemic pathways

Soranzo N, Sanna S, Wheeler E, Gieger C, Radke D, Dupuis J, Bouatia-Naji N, Langenberg C, Prokopenko I, Stolerman E, Sandhu MS, Heeney MM, Devaney JM, Reilly MP, Ricketts SL, Stewart AF, Voight BF, Willenborg C, Wright B, Altshuler D, et al. on behalf of Procardis Consortium. DIABETES (NY) 59: 3229-3239. 2010

Partial hexokinase II knocout results in acute ischemia-reperfusion damage in skeletal muscle of male, but not female, mice

Smeele KM, Eerbeek O, Koeman A, Bezemer R, Ince C, Heikkinen S, Laakso M, de Haan A, Schaart G, Drost MR, et al. PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY 459: 705-712. 2010

The metabolic syndrome predicts incident congestive heart failure: a 20-year follow-up study of elderly Finns

Wang J, Sarnola K, Ruotsalainen S, Moilanen L, Lepistö P, Laakso M & Kuusisto J. ATHEROSCLEROSIS 210: 237-242. 2010

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.

Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, Allen HL, Lindgren CM, ..., Kuusisto J, ..., Laakso M, et al.. NATURE GENETICS 42: 937-948. 2010

Common variants in the ATP2B1 gene are associated with susceptibility to hypertension: the Japanese Millenium Genome Project

Tabara Y, Kohara K, Kita Y, Hirawa N, Katsuya T, Ohkubo T, Hiura Y, Tajima A, Morisaki T, Miyata T, et al.. HYPERTENSION 56 5: 973-980. 2010

Proteinuria modifies the effects of physical activity on total and cardiovascular disease mortality rates in patients with type 2 diabetes

Vepsäläinen T, Soinio M, Lehto S, Juutilainen A, Laakso M, Rönnemaa T. DIABETOLOGIA 53: 1886-1889. 2010

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

Voight BF,Scott LJ,Steinthorsdottir V,Morris AP,Dina C,Welch RP,Zeggini E,Huth C,..., ,Kuusisto J,..., Laakso M,et al.. NATURE GENETICS 42: 579-589. 2010

Identification of undiagnosed type 2 diabetic individuals by the Finnish diabetes risk score, biochemical and genetic markers: A population-based study of 7232 Finnish men

Wang J, Stancakova A, Kuusisto J, Laakso M. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 95: 3858-3862. 2010

The D299G/T3991 toll-like receptor 4 variant associates with body and liver fat: results from the TULIP and METSIM studies

Weyrich P, Staiger H, Stancakova A, Machicao F, Machann J, Schick F, Stefan N, Kuusisto J, Laakso M, Schäfer S, Fritsche A, Häring H-U. PLOS ONE [ONLINE] 5 11: e13980. 2010

Reduction in hexokinase II levels results in decreased cardiac function and altered remodeling after ischemia-reperfusion injury

Wu R, Smeele KM, Wyatt E, Ichikawa Y, Eerbeek O, Sun L, Chawla K, MS, Hollmann MW, Nagpal V, Heikkinen S, Laakso M, Jujo K, Wasserstrom JA, Zuurbier CJ, Ardehali H. CIRCULATION RESEARCH 108: 60-69. 2010

Insulin sensitivity and beta-cell function in the offspring of type 2 diabetic patients: impact of line of inheritance

Natali A, Muscelli E, Mari A, Balkau B, Walker M, Tura A, Anderwald C, Golay A, & Ferrannini E, the Relationship between Insulin Sensitivity and Cardiovascular disease investigators. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 95 10: 4703-4711. 2010

Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies.

Nettleton JA, McKeown NM, Kanoni S, Lemaitre RN, Hivert MF, Ngwa J, van Rooij FJ, Sonestedt E, Wojczynski MK, Ye Z, Tanaka T, Garcia M, Anderson JS, Follis JL, Djousse L, Mukamal K, Papoutsakis C, Mozaffarian D, Zillikens MC, Bandinelli S (including M Laakso). DIABETES CARE 33 12: 2684-2691. 2010

Effect of valsartan on the incidence of diabetes and cardiovascular events

McMurray JJ, Holman RR, Haffner SM, Bethel MA, Holzhauer B, Hua TA, Belenkov Y, Boolell M, Buse JB, Buckley BM, Chacra AR, Chiang F-T, Charbonnel B, Chow C-C, Davies MJ, Deedwania P, Diem P, Einhorn D, Fonseca V, Fulcher GR, et al. for The NAVIGAT. NEW ENGLAND JOURNAL OF MEDICINE 362: 1477-1490. 2010

Depression is associated with the metabolic syndrome among patients with type 1 diabetes

Ahola AJ, Thorn LM, Saraheimo M, Forsblom C, Groop P-H, & on behalf of the Finndiane Study Group. Annals of Medicine 42: 495-501. 2010

Four Novel loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo

Ikram MK, Xueling S, Jensen RA, Cotch MF, Hewitt AW, Ikram MA, Wang JJ, Klein R, Klein BE, Breteler MMB, et al.. PLOS ONE [ONLINE] 6 10: e1001184. 2010

Impaired beta cell glucose sensitivity rather than inadequate compensation for insulin resistance is the dominant defect in glucose intolerance

Mari A, Tura A, Natali A, Laville M, Laakso M, Gabriel R, Beck-Nielsen H, Ferrannini E, RISC Investigators. DIABETOLOGIA 53: 749-756. 2010

Impact of family history on relations between insulin resistance, LDL cholesterol and carotid IMT in healthy adults

Anderwald C, Stadler M, Golay A, Krebs M, Petrie J, Luger A on behalf of the RISC Investigators. HEART 96: 1191-1200. 2010

Incidence and predictors of silent myocardial infarction in type 2 diabetes and the effect of fenofibrate: an analysis from the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study

Burgess DC, Hunt D, Li L, Zannino D, Williamson E, Davis TM, Laakso M, Kesäniemi YA, Zhang J, Sy RW, et al.. EUROPEAN HEART JOURNAL 31: 92-99. 2010

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Kuusisto J, Laakso M, et al.. NATURE GENETICS 42: 105-116. 2010

Insulin sensitivity regulates cholesterol metabolism to a greater extent than obesity. Lessons from the METSIM study.

Gylling H, Hallikainen M, Pihlajamaki J, Simonen P, Kuusisto J, Laakso M, Miettinen TA.. JOURNAL OF LIPID RESEARCH 51: 2422-2427. 2010

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

Heid IM, Jackson AU, Randall JC, Winkler TW, Qi L, Steinthorsdottir V, Thorleifsson G, Zillikens MC, ..., Kuusisto J, ... , Laakso M, et al.. NATURE GENETICS 42: 949-960. 2010

Effect of nateglinide on the incidence of diabetes and cardiovascular events

Holman RR, Haffner SM, McMurray JJ, Bethel MA, Holzhauer B, Hua TA, Belenkov Y, Boolell M, Buse JB, ..., Laakso M, et al.. NEW ENGLAND JOURNAL OF MEDICINE 362: 1463-1476. 2010

Age at onset and the risk of proliferative retinopathy in type 1 diabetes

Hietala K, Harjutsalo V, Forsblom C, Summanen P, Groop PH, FinnDiane Study Group. DIABETES CARE 33: 1315-1319. 2010

Detailed Physiologic Characterization Reveals Diverse Mechanisms for Novel Genetic Loci Regulating Glucose and Insulin Metabolism in Humans

Ingelsson E, Langenberg C, Hivert MF, ProkopenkoI, Lyssenko V, Dupuis J, Mägi R, Sharp S, ..., Kuusisto J, Laakso M, et al. DIABETES (NY) 59: 1266-1275. 2010

Lipid disorders in type 2 diabetes

Laakso M. Endocrinol Nutr 56: 43-45. 2010

Relation of direct and surrogate measures of insulin resistance to cardiovascular risk factors in nondiabetic Finnish offspring of type 2 diabetic individuals

Lorenzo C, Haffner SM, Stancakova A, Laakso M. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 95 11: 5082-5090. 2010

Thoracoabdominal calcifications predict cardiovascular disease mortality in type 2 diabetic and nondiabetic subjects. A 18-year follow-up study

Juutilainen A, Lehto S, Suhonen M, Rönnemaa T, Laakso M. DIABETES CARE 33: 583-585. 2010

Polymorphism Pro12Ala of PPARG in Prepubertal Children with Premature Adrenarche and Its Association with Growth in Healthy Children

Laakso S, Utriainen P, Laakso M, Voutilainen R & Jääskeläinen J. HORMONE RESEARCH IN PAEDIATRICS 74: 365-371. 2010

Genetic Variation of DKK3 May Modify Renal Disease Severity in ADPKD.

Liu M, Shi S, Senthilnathan S, Yu J, Wu E, Bergmann C, Zerres K, Bogdanova N, Coto E, ..., Laakso M, et al.. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 21: 1510-1520. 2010

Cardiovascular disease in type 2 diabetes. From population to man to mechanisms: Kelly West Lecture 2008

Laakso M. DIABETES CARE 33: 442-449. 2010

Effect of sedentary behaviour and vigorous physical activity on segment-specific carotid wall thickness and its progression in a healthy population

Kozakova M, Palombo C, Morizzo C, Nolan JJ, Konrad T, Balkau B, the RISC Investigtors. EUROPEAN HEART JOURNAL 31: 1511-1519. 2010

The rs1800629 polymorphism in the TNF gene interacts with physical activity on the changes in C-reactive protein levels in the Finnish diabetes prevention study

Kilpeläinen TO, Laaksonen DE, Lakka TA, Herder C, Koenig W, Lindström J, Eriksson JG, Uusitupa M, Kolb H, Laakso M, Tuomilehto J, for the Finnish Diabetes Prevention Study Group. EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY AND DIABETES 118 10: 757-759. 2010

Early autonomic dysfunction in type 1 diabetes: a reversible disorder?

Rosengård-Bärlund M, Bernardi L, Fagerudd J, Mäntysaari M, Af Björkesten CG, Lindholm H, Forsblom C, Wadén J, Groop PH, FinnDiane Study Group, Laakso M, Niskanen L, Vauhkonen I, Voutilainen E, Mykkänen L, Karhapää P. DIABETOLOGIA 52: 1164-1172. 2009

Association of common genetic variation in the FOXO1 gene with beta-cell dysfunction, impaired glucose tolerance, and type 2 diabetes

Müssig K, Staiger H, Machicao F, Stancáková A, Kuusisto J, Laakso M, Thamer C, Machann J, Schick F, Claussen CD, Stefan N, Fritsche A, Häring H-U. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 94: 1353-1360. 2009

Genome-wide association study identifies eight loci associated with blood pressure

Newton-Cheh C, Johnson T, Gateva V, Tobin MD, Bochud M, Coin L, Najjar SS..., Lucas G, Kuusisto J, Burton PR, Hadley D, McArdle WL, Wellcome TRUST Case Control Consortium, Brown M, Dominiczak A, Newhouse SJ, Samani NJ..., Laakso M. NATURE GENETICS 41: 666-676. 2009

Serum lipopolysaccharide activity is associated with the progression of kidney disease in finnish patients with type 1 diabetes

Nymark M, Pussinen PJ, Tuomainen AM, Forsblom C, Groop PH, Lehto M, on behalf of the FinnDiane Study Group, Karhapää P, Laakso M, Lumiaho A, Moilanen L, Niskanen L, Vauhkonen I, Voutilainen E. DIABETES CARE 32: 1689-1693. 2009

Galanin preproprotein is associated with elevated plasma triglycerides

Plaisier CL, Kyttälä M, Weissglas-Volkov D, Sinsheimer JS, Huertas-Vazquez A..., Pullinger CR, Malloy MJ, Kane JP, Cruz-Bautista I, Herrera MF, Aguilar-Salinas C, Kuusisto J, Laakso M, Taskinen MR, van der Kallen CJ, Pajukanta P. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 29: 147-152. 2009

Variants in MTNR1B influence fasting glucose levels

Prokopenko I, Langenberg C, Florez JC, Saxena R, Soranzo N, Thorleifsson G, Loos RJ, Manning AK, Jackson AU, Aulchenko Y, Potter SC, Erdos MR, Sanna S, Hottenga JJ, Wheeler E, Kaakinen M, Lyssenko V, Chen WM, Ahmadi K..., Kuusisto J, Laakso M. NATURE GENETICS 41: 77-81. 2009

Interaction between prenatal growth and high-risk genotypes in the development of type 2 diabetes

Pulizzi N, Lyssenko V, Jonsson A, Osmond C, Laakso M, Kajantie E, Barker DJ, Groop LC, Eriksson JG. DIABETOLOGIA 52: 825-829. 2009

Effect of fenofibrate on amputation events in people with type 2 diabetes mellitus (FIELD study): a prespecified analysis of a randomised controlled trial

Rajamani K, Colman PG, Li LP, Best JD, Voysey M, D'Emden MC, Laakso M, Baker JR, Keech AC, on behalf of the FIELD Study Investigators. LANCET 373: 1780-1788. 2009

Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

Lyssenko V, Nagorny CLF, Erdos MR, Wierup N, Jonsson A, Spégel P, Bugliani M, Saxena R, Fex M, Pulizzi N, Isomaa B, Tuomi T, Nilsson P, Kuusisto J, Tuomilehto J, Boehnke M..., Laakso M, Marchetti P, Watanabe RM, Mulder H, Groop L. NATURE GENETICS 41: 82-88. 2009

Underlying genetic models of inheritance in established type 2 diabetes associations

Salanti G, Southam L, Altshuler D, Ardlie K, Barroso I, Boehnke M, Cornelis MC, Frayling TM, Grallert H, Grarup N, Groop L, Hansen T, Hattersley AT, Hu FB, Hveem K, Illig T, Kuusisto J, Laakso M, Langenberg C.... AMERICAN JOURNAL OF EPIDEMIOLOGY 170: 537-545. 2009

Variation in the UCP2 and UCP3 genes associated with abdominal obesity and serum lipids: The Finnish diabetes prevention study

Salopuro T, Pulkkinen L, Lindström J, Kolehmainen M, Tolppanen A-M, Eriksson JG, Valle TT, Aunola S, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Laakso M, Uusitupa M, Salopuro T, Pulkkinen L, Kolehmainen M, Tolppanen A-M, Uusitupa M. BMC MEDICAL GENETICS [ONLINE: HTTP://WWW.BIOMEDCENTRAL.COM/BMCMEDGENET/] 10 94: [13 p.]. 2009

Changes in insulin sensitivity and insulin release in relation to glycemia and glucose tolerance in 6,414 Finnish men

Stancáková A, Javorský M, Kuulasmaa T, Haffner SM, Kuusisto J, Laakso M. DIABETES (NY) 58: 1212-1221. 2009

Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men

Stancáková A, Kuulasmaa T, Paananen J, Jackson AU, Bonnycastle LL, Collins FS, Boehnke M, Kuusisto J, Laakso M. DIABETES (NY) 58: 2129-2136. 2009

Metabolic syndrome as a risk factor for cardiovascular disease, mortality, and progression of diabetic nephropathy in type 1 diabetes

Thorn LM, Forsblom C, Wadén J, Saraheimo M, Tolonen N, Hietala K, Groop P-H, for the Finnish Diabetic Nephropathy (FinnDiane) Study Group, Karhapää P, Laakso M, Moilanen L, Niskanen L, Vauhkonen I. DIABETES CARE 32: 950-952. 2009

A1C variability predicts incident cardiovascular events, microalbuminuria, and overt diabetic nephropathy in patients with type 1 diabetes

Wadén J, Forsblom C, Thorn LM, Gordin D, Saraheimo M, Groop PH, on behalf of the Finnish Diabetic Nephropathy Study Group, Karhapää P, Laakso M, Niskanen L, Vauhkonen I, Voutilainen E, Moilanen L. DIABETES (NY) 58: 2649-2655. 2009

Adult stature and diabetes complications in patients with type 1 diabetes: the FinnDiane Study and the diabetes control and complications trial

Wadén J, Forsblom C, Thorn LM, Saraheimo M, Rosengård-Bärlund M, Heikkilä O, Hietala K, Ong K, Wareham N, Groop PH, on behalf of the FinnDiane Study Group, Laakso M, Moilanen L, Niskanen L, Vauhkonen I, Voutilainen E. DIABETES (NY) 58: 1914-1920. 2009

Common polymorphisms within the NR4A3 locus, encoding the orphan nuclear receptor Nor-1, are associated with enhanced beta-cell function in non-diabetic subjects

Weyrich P, Staiger H, Stancáková A, Schäfer SA, Kirchhoff K, Ullrich S, Ranta F, Gallwitz B, Stefan N, Machicao F, Kuusisto J, Laakso M, Fritsche A, Häring H-U. BMC MEDICAL GENETICS [ONLINE: HTTP://WWW.BIOMEDCENTRAL.COM/BMCMEDGENET/] 10: 77. 2009

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

Willer CJ, Speliotes EK, Loos RJ, Li S, Lindgren CM, Heid IM, Berndt SI, Elliott AL, Jackson AU, Lamina C, Lettre G, Lim N..., Burtt NP, Chines P, Coin L, Collins FS, Connell JM, Cooper C, Smith GD, Dennison EM, Kuusisto J, Laakso M. NATURE GENETICS 41: 25-34. 2009

The ATF6-Met[67]Val substitution is associated with increased plasma cholesterol levels

Meex SJR, Weissglas-Volkov D, van der Kallen CJH, Thuerauf DJ, van Greevenbroek MMJ, Schalkwijk CG, Stehouwer CDA, Feskens EJM, Heldens L, Ayoubi TA, Hofker MH, Wouters BG..., Taskinen M-R, Kuusisto J, Laakso M, de Bruin TWA.... ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 29: 1322-1327. 2009

Gender differences relating to metabolic syndrome and proinflammation in Finnish subjects with elevated blood pressure

Ahonen T, Saltevo J, Laakso M, Kautiainen H, Kumpusalo E, Vanhala M. MEDIATORS OF INFLAMMATION (ONLINE) 959281: [6 p.]. 2009

Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution

Lindgren CM, Heid IM, Randall JC, Lamina C, Steinthorsdottir V, Qi L, Speliotes EK, Thorleifsson G, Willer CJ, Herrera BM..., Cherkas L, Chines P, Coin L, Cooper C, Crawford G, Doering A, Dominiczak A, Doney..., Laakso M, Kuusisto J. PLOS GENETICS [ONLINE) 5: e1000508. 2009

Common variants at 30 loci contribute to polygenic dyslipidemia

Kathiresan S, Willer CJ, Peloso GM, Demissie S, Musunuru K, Schadt EE, Kaplan L, Bennett D, Li Y, Tanaka T..., Kuusisto J, Bergman RN..., Laakso M, Ferrucci L, Scheet P..., Dupuis J, de Bakker PI, O'Donnell CJ, Chambers JC, Kooner JS. NATURE GENETICS 41: 56-65. 2009

Additive effects of genetic variation in GCK and G6PC2 on insulin secretion and fasting glucose

Li X, Shu Y-H, Xiang AH, Trigo E, Kuusisto J, Hartiala J, Swift AJ, Kawakubo M, Stringham HM, Bonnycastle LL, Lawrence JM, Laakso M, Allayee H, Buchanan TA, Watanabe RM. DIABETES (NY) 58: 2946-2953. 2009

Fasting insulin has a stronger association with an adverse cardiometabolic risk profile than insulin resistance: the RISC study

de Rooij SR, Dekker JM, Kozakova M, Mitrakou A, Melander O, Gabriel R, Guidone C, Højlund K, Murphy MS, Nijpels G, and the RISC Group Investigators, Laakso M. EUROPEAN JOURNAL OF ENDOCRINOLOGY 161: 223-230. 2009

Low-grade chronic inflammation in the relationship between insulin sensitivity and cardiovascular disease (RISC) population: associations with insulin resistance and cardiometabolic risk profile

de Rooij SR, Nijpels G, Nilsson PM, Nolan JJ, Gabriel R, Bobbioni-Harsch E, Mingrone G, Dekker JM, for the Relationship Between Insulin Sensitivity And Cardiovascular, Disease (risc) Investigators, Laakso M. DIABETES CARE 32: 1295-1301. 2009

Fatty liver is associated with insulin resistance, risk of coronary heart disease, and early atherosclerosis in a large European population

Gastaldelli A, Kozakova M, Hojlund K, Flyvbjerg A, Favuzzi A, Mitrakou A, Balkau B, the RISC Investigators, Laakso M. HEPATOLOGY 49: 1537-1544. 2009

The presence and severity of chronic kidney disease predicts all-cause mortality in type 1 diabetes

Groop PH, Thomas MC, Moran JL, Wadèn J, Thorn LM, Mäkinen V-P, Rosengård-Bärlund M, Saraheimo M, Hietala K, Heikkilä O, Forsblom C, on behalf of the FinnDiane Study Group, Laakso M, Niskanen L, Vauhkonen I, Voutilainen E, Mykkänen L, Karhapää P. DIABETES (NY) 58: 1651-1658. 2009

The metabolism of plant sterols is disturbed in postmenopausal women with coronary artery disease

Gylling H, Hallikainen M, Rajaratnam RA, Simonen P, Pihlajamäki J, Laakso M, Miettinen TA. METABOLISM: CLINICAL AND EXPERIMENTAL 58: 401-407. 2009

The Pro12Ala PPARgamma2 variant determines metabolism at the gene-environment interface

Heikkinen S, Argmann C, Feige JN, Koutnikova H, Champy M-F, Dali-Youcef N, Schadt EE, Laakso M, Auwerx J. 9: 88-98. 2009

The Pro12Ala polymorphism of the PPARgamma2 gene is associated with hepatic glucose uptake during hyperinsulinwmia in subjects with type 2 diabetes mellitus

Honka M-J, Vänttinen M, Iozzo P, Virtanen KA, Lautamäki R, Hällsten K, Borra RJH, Takala T, Viljanen APM, Kemppainen J, Pihlajamäki J, Knuuti J, Nuutila P, Laakso M. METABOLISM: CLINICAL AND EXPERIMENTAL 58: 541-546. 2009

Variant near ADAMTS9 known to associate with type 2 diabetes is related to insulin resistance in offspring of type 2 diabetes patients-EUGENE2 study

Boesgaard TW, Gjesing AP, Grarup N, Rutanen J, Jansson P-A, Hribal ML, Sesti G, Fritsche A, Stefan N, Staiger H, Häring H, Smith U, Laakso M, Pedersen O, Hansen T, for the EUGENE2 Consortium. PLOS ONE [ONLINE] 4: e7236. 2009

Elevated MBL concentrations are not an indication of association between the MBL2 gene and type 1 diabetes or diabetic nephropathy

Kaunisto MA, Sjölind L, Sallinen R, Pettersson-Fernholm K, Saraheimo M, Fröjdö S, Forsblom C, Fagerudd J, Hansen TK, Flyvbjerg A, Wessman M, Groop PH, FinnDiane Study Group, Laakso M, Niskanen L, Vauhkonen I, Voutilainen E, Mykkänen L, Karhapää P. DIABETES (NY) 57: 1710-1714. 2009

Not for the eyes only: PAX6 and glucose metabolism

Laakso M. DIABETOLOGIA 52: 381-384. 2009

Increased serum levels of methylglyoxal-derived hydroimidazolone-AGE are associated with increased cardiovascular disease mortality in nondiabetic women

Kilhovd BK, Juutilainen A, Lehto S, Rönnemaa T, Torjesen PA, Hanssen KF, Laakso M. ATHEROSCLEROSIS 205: 590-594. 2009

Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response

Langenberg C, Pascoe L, Mari A, Tura A, Laakso M, Frayling TM, Barroso I, Loos RJF, Wareham NJ, Walker M, the RISC Consortium. DIABETOLOGIA 52: 1537-1542. 2009

Genetic variation of FTO and TCF7L2 in premature adrenarche

Lappalainen S, Voutilainen R, Utriainen P, Laakso M, Jääskeläinen J. METABOLISM: CLINICAL AND EXPERIMENTAL 58: 1263-1269. 2009

Natural history of type 2 diabetes and macrovascular disease

Laakso M. Serrano-Riós M, Gutiérrez-Fuentes JA, Type 2 Diabetes Mellitus.Elsevier. 151-166. 2009

Endokriinisten sairauksien geenidiagnostiikka

Laakso M. Välimäki M, Sane T, Dunkel L, Endokrinologia.Duodecim. 50-62. 2009

Identification of the UBP1 locus as a critical blood pressure determinant using a combination of mouse and human genetics

Koutnikova H, Laakso M, Lu L, Combe R, Paananen J, Kuulasmaa T, Kuusisto J, Häring H-U, Hansen T, Pedersen O, Smith U, Hanefeld M, Williams RW, Auwerx J. PLOS GENETICS [ONLINE) 5: e100591. 2009

Parental origin of sequence variants associated with complex diseases

Kong A, Steinthorsdottir V, Masson G, Thorleifsson G..., ...Johannsson OT, Hreidarsson AB, Sigurdsson G, DIAGRAM Consortium, Laakso M, Kuusisto J. NATURE (LONDON) 462: 868-874. 2009

Sleep-disordered breathing and type 2 diabetes. A report from the International Diabetes Federation Taskforce on Epidemiology and Prevention

Shaw JE, Punjabi NM, Wilding JP, Alberti KGMM, Zimmet PZ, Laakso M. DIABETES RESEARCH AND CLINICAL PRACTICE 81: 2-12. 2008

Prognostic role of pro- and anti-inflammatory cytokines and their polymorphisms in acute decompensated heart failure

Miettinen KH, Lassus J, Harjola VP, Siirilä-Waris K, Melin J, Punnonen KR, Nieminen MS, Laakso M, Peuhkurinen KJ. EUROPEAN JOURNAL OF HEART FAILURE 10 4: 396-403. 2008

Metabolic phenotypes, vascular complications, and premature deaths in a population of 4,197 patients with type 1 diabetes

Mäkinen V-P, Forsblom C, Thorn LM, Wadén J, Gordin D, Heikkilä O, Hietala K, Kyllönen L, Kytö J, Rosengård-Bärlund M, Saraheimo M, Tolonen N, Parkkonen M, Kaski K, Ala-Korpela M, Groop P-H, on behalf of the FinnDiane Study Group, Huttunen E. DIABETES (NY) 57: 2480-2487. 2008

Variation in the ADIPOQ gene promoter is associated with carotid intima media thickness independent of plasma adiponectin levels in healthy subjects

Patel S, Flyvbjerg A, Kozàkovà M, Frystyk J, Ibrahim IM, Petrie JR, Avery PJ, Ferrannini E, Walker M, RISC Investigators, Laakso M. EUROPEAN HEART JOURNAL 29: 386-393. 2008

Markes of endothelial dysfunction and low-grade inflammation are associated in the offspring of type 2 diabetic subjects

Ruotsalainen E, Vauhkonen I, Salmenniemi U, Pihlajamäki J, Punnonen K, Kainulainen S, Jalkanen S, Salmi M, Laakso M. ATHEROSCLEROSIS 197: 271-277. 2008

Levels of adiponectin, C-reactive protein and interleukin-1 receptor antagonist are associated with insulin sensitivity: a population-based study

Saltevo J, Laakso M, Jokelainen J, Keinänen-Kiukaanniemi S, Kumpusalo E, Vanhala M. DIABETES, METABOLISM RESEARCH AND REVIEWS 24: 378-383. 2008

Gender differences in C-reactive protein, interleukin-1 receptor antagonist and adiponectin levels in the metabolic syndrome: a population-based study

Saltevo J, Vanhala M, Kautiainen H, Kumpusalo E, Laakso M. DIABETIC MEDICINE 25: 747-750. 2008

Serum adiponectin and progression of diabetic nephropathy in patients with type 1 diabetes

Saraheimo M, Forsblom C, Thorn L, Wadén J, Rosengård-Bärlund M, Heikkilä O, Hietala K, Gordin D, Frystyk J, Flyvbjerg A, Groop PH, on behalf of the FINNDIANE Study Group, Laakso M, Niskanen L, Vauhkonen I, Voutilainen E, Mykkänen L, Karhapää P. DIABETES CARE 31: 1165-1169. 2008

Molecular cloning and characterization of the human PED/PEA-15 gene promoter reveal antagonistic regulation by hepatocyte nuclear factor 4alpha and chicken ovalbumin upstream promoter transcription factor II

Ungaro P, Teperino R, Mirra P, Cassese A, Fiory F, Perruolo G, Miele C, Laakso M, Formisano P, Beguinot F. JOURNAL OF BIOLOGICAL CHEMISTRY 283: 30970-30979. 2008

A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study

Staiger H, Stancáková A, Zilinskaite J, Vänttinen M, Hansen T, Marini MA, Hammarstedt A, Jansson P-A, Sesti G, Smith U, Pedersen O, Laakso M, Stefan N, Fritsche A, Häring H-U. DIABETES (NY) 57: 514-517. 2008

Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance

Stancáková A, Pihlajamäki J, Kuusisto J, Stefan N, Fritsche A, Häring H, Andreozzi F, Succurro E, Sesti G, Boesgaard TW, Hansen T, Pedersen O, Jansson PA, Hammarstedt A, Smith U, Laakso M, for the EUGENE2 Consortium. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 93 5: 1924-1930. 2008

Effects of ramipril and rosiglitazone on cardiovascular and renal outcomes in people with impaired glucose tolerance or impaired fasting glucose. Results of the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) trial

The DREAM Trial Investigators, Laakso M. DIABETES CARE 31: 1007-1014. 2008

Relationship between lipid profiles and kidney function in patients with type 1 diabetes

Tolonen N, Forsblom C, Thorn L, Wadén J, Rosengård-Bärlund M, Saraheimo M, Heikkilä O, Pettersson-Fernholm K, Taskinen MR, Groop PH, FinnDiane Study Group, Karhapää P, Laakso M, Mykkänen L, Niskanen L, Vauhkonen I, Voutilainen E. DIABETOLOGIA 51: 12-20. 2008

Physical activity and diabetes complications in patients with type 1 diabetes. The Finnish Diabetic Nephropathy (FinnDiane) Study

Wadén J, Forsblom C, Thorn LM, Saraheimo M, Rosengård-Bärlund M, Heikkilä O, Lakka TA, Tikkanen H, Groop PH, FinnDiane Study Group, Karhapää P, Laakso M, Moilanen L, Niskanen L, Vauhkonen I, Voutilainen E. DIABETES CARE 31: 230-232. 2008

The metabolic syndrome predicts incident stroke: a 14-year follow-up study in elderly people in Finland

Wang J, Ruotsalainen S, Moilanen L, Lepistö P, Laakso M, Kuusisto J. STROKE 39: 1078-1083. 2008

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

Zeggini E, Scott LJ, Saxena R, Voight BF, for the Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium, Laakso M, Kuusisto J. NATURE GENETICS 40 5: 638-645. 2008

The G-250A polymorphism in the hepatic lipase gene promotor is associated with changes in hepatic lipase activity and LDL cholesterol:The KANWU study

Lindi V, Schwab U, Louheranta A, Vessby B, Hermansen K, Tapsell L, Riccardi G, Rivellese AA, Laakso M, Uusitupa MIJ, KANWU Study Group. NUTRITION, METABOLISM AND CARDIOVASCULAR DISEASES 18: 88-95. 2008

IL5RA and TNFRSF6B gene variants are associated with sporadic IgA nephropathy

Liu X-Q, Paterson AD, He N, St George-Hyslop P, Rauta V, Gronhagen-Riska C, Laakso M, Thibaudin L, Berthoux F, Cattran D, Pei Y. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 19: 1025-1033. 2008

Cardiovascular protection for all individuals at high risk: evidence-based best practice

Bakris G, Böhm M, Dagenais G, Diener H-C, Fujita T, Gorelick P, Kjeldsen SE, Laakso M, Mancia G, Pitt B, Sharma A, Sleight P, Teo K, Unger T, Weber M, Williams B, Zannad F. CLINICAL REARCH IN CARDIOLOGY 97: 713-725. 2008

WW-domain-containing oxidoreductase is associated with low plasma HDL-C levels

Lee JC, Weissglas-Volkov D, Kyttäjä M, Dastani Z, Cantor RM, Sobel EM, Plaisier CL, Engert JC, van Greenvenbroek MMJ, Kane JP, Malloy MJ..., Kuusisto J, Laakso M, Taskinen M-R, Genest J, Pajukanta P. AMERICAN JOURNAL OF HUMAN GENETICS 83: 180-192. 2008

High circulating levels of RBP4 and mRNA levels of aP2, PGC-1alpha and UCP-2 predict improvement in insulin sensitivity following pioglitazone treatment of drug-naïve type 2 diabetic subjects

Hammerstedt A, Pihlajamäki J, Graham TE, Kainulainen S, Kahn BB, Laakso M, Smith U. JOURNAL OF INTERNAL MEDICINE 263: 440-449. 2008

Physical activity and insulin sensitivity: the RISC Study

Balkau B, Mhamdi L, Oppert J-M, Nolan J, Golay A, Porcellati F, Laakso M, Ferrannini E, on behalf of the EGIR-RISC Study Group. DIABETES (NY) 57: 2613-2618. 2008

The common SLC30A8 Arg325Trp variant is associated with reduced first-phase insulin release in 846 non-diabetic offspring of type 2 diabetes patients - the EUGENE2 study

Boesgaard TW, Zilinskaite J, Vänttinen M, Laakso M, Jansson P-A, Hammarstedt A, Smith U, Stefan N, Fritsche A, Häring H, Hribal M, Sesti G, Zobel DP, Pedersen O, Hansen T, for the EUGENE 2 Consortium. DIABETOLOGIA 51: 816-820. 2008

Influence of the ACE gene insertion/deletion polymorphism on insulin sensitivity and impaired glucose tolerance in healthy subjects

Bonnet F, Patel S, Laville M, Balkau B, Favuzzi A, Monti LD, Lalic N, Walker M, European GROUP For the Study of Insulin Resistance Relationship Between Insulin Sensitivity And Cardiovascular Disease Risk Study Group., Laakso M. DIABETES CARE 31: 789-794. 2008

Prevention of diabetes and cardiovascular disease in patients with impaired glucose tolerance: rationale and design of the Nateglinide And Valsartan in Impaired Glucose Tolerance Outcomes Research (NAVIGATOR) Trial

Califf RM, Boolell M, Haffner SM, Bethel MA, McMurray J, Duggal A, Holman RR, for the NAVIGATOR Study Group, Laakso M. AMERICAN HEART JOURNAL 156: 623-632. 2008

Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels

Chen W-M, Erdos MR, Jackson AU..., Kuusisto J, Ebrahim S..., Laakso M. JOURNAL OF CLINICAL INVESTIGATION 118: 2620-2628. 2008

Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance

Chibalin AV, Leng Y, Vieira E, Krook A, Björnholm M, Long YC, Kotova O, Zhong Z, Sakane F, Steiler T, Nylén C, Wang J, Laakso M, Topham MK, Gilbert M, Wallberg-Henriksson H, Zierath JR. CELL 132: 375-386. 2008

Variance of the SGK1 gene is associated with insulin secretion in different European populations: results from the TUEF, EUGENE2, AND METSIM studies

Friedrich B, Weyrich P, Stancakova A, Wang J, Kuusisto J, Laakso M, Sesti G, Succurro E, Smith U, Hansen T, Pedersen O, Machicao F, Schäfer S, Lang F, Risler T, Ullrich S, Stefan N, Fritsche A, Häring H-U. PLOS ONE [ONLINE] 3 11: e3506. 2008

Electrocardiographic alterations during hyperinsulinemic hypoglycemia in healthy subjects

Laitinen T, Lyyra-Laitinen T, Huopio H, Vauhkonen I, Halonen T, Hartikainen J, Niskanen L, Laakso M. ANNALS OF NONINVASIVE ELECTROCARDIOLOGY 13 2: 97-105. 2008

Genetic study between SIRT1, PPARD, PGC-1alfa genes and Alzheimer's disease

Helisalmi S, Vepsäläinen S, Hiltunen M, Koivisto AM, Salminen A, Laakso M, Soininen H, Soininen H. JOURNAL OF NEUROLOGY 255: 668-673. 2008

Interaction of single nucleotide polymorphisms in ADRB2, ADRB3, TNF, IL6, IGF1R, LIPC, LEPR, and GHRL with physical activity on the risk of type 2 diabetes mellitus and changes in characteristics of the metabolic syndrome. The Finnish Diabetes Prevention Study

Kilpeläinen TO, Lakka TA, Laakosnen DE, Mager U, Salopuro T, Kubaszek A, Todorova B, Laukkanen O, Lindström J, Eriksson JG, Hämäläinen H, Aunola S, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Laakso M, Uusitupa M. METABOLISM: CLINICAL AND EXPERIMENTAL 57: 428-436. 2008

SNPs in PPARG associte with type 2 diabetes and intract with physival activity

Kilpeläinen TO, Lakka TA, Laaksonen DE, Lindström J, Eriksson JG, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Lindi V, Tuomilehto J, Uusitupa M, Laakso M. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE 40: 25-33. 2008

Early familial dilated cardiomyopathy: Identification with determination of disease state parameter from cine MR image data

Koikkalainen JR, Antila M, Lötjönen JMP, Heliö T, Lauerma K, Kivistö SM, Sipola P, Kaartinen MA, Kärkkäinen STJ, Reissell E, Kuusisto J, Laakso M, Oresic M, Nieminen MS, Peuhkurinen KJ. RADIOLOGY 249 1: 88-96. 2008

Body composition and common carotid artery remodeling in a healthy population

Kozakova M, Palombo C, Paterni M, Anderwald CH, Konrad T, Colgan MP, Flyvbjerg A, Dekker J, Relationship between Insulin Sensitivity Cardiovascular Risk Investigators, Laakso M. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 93: 3325-3332. 2008

Insulin sensitivity, insulin release and glucagon-like peptide-1 levels in persons with impaired fasting glucose and/or impaired glucose tolerance in the EUGENE2 study

Laakso M, Zilinskaite J, Hansen T, Boesgaard TW, Vänttinen M, Stancáková A, Jansson P-A, Pellmé F, Holst JJ, Kuulasmaa T, Hribal ML, Sesti G, Stefan N, Fritsche A, Häring H, Pedersen O, Smith U, for the EUGENE2 Consortium. DIABETOLOGIA 51: 502-511. 2008

Diabetes as a 'cardiovascular disease equivalent': implications for treatment

Laakso M. NATURE CLINICAL PRACTICE. CARDIOVASCULAR MEDICINE 5 11: 682-683. 2008

Similarity of the impact of type 1 and type 2 diabetes on cardiovascular mortality in middle-aged subjects

Juutilainen A, Lehto S, Rönnemaa T, Pyörälä K, Laakso M. DIABETES CARE 31: 714-719. 2008

Serum zinc level and coronary heart disease events in patients with type 2 diabetes

Soinio M, Marniemi J, Laakso M, Pyörälä K, Lehto S, Rönnemaa T. DIABETES CARE 30: 523-528. 2007

Enhanced polyamine catabolism alters homeostatic control of white adipose tissue mass, energy expenditure, and glucose metabolism

Pirinen E, Kuulasmaa T, Pietilä M, Heikkinen S, Tusa M, Itkonen P, Boman S, Skommer J, Virkamäki A, Hohtola E, Kettunen M, Fatrai S, Kansanen E, Koota S, Niiranen K, Parkkinen J, Levonen A-L, Ylä-Herttuala S, Hiltunen JK, Alhonen L, Smith U, Jänne J. MOLECULAR AND CELLULAR BIOLOGY 27 13: 4953-4967. 2007

Single nucleotide polymorphisms of the MCHR1 gene do not affect metabolism in humans

Rutanen J, Pihlajamäki J, Vänttinen M, Salmenniemi U, Ruotsalainen E, Kuulasmaa T, Kainulainen S, Kuusisto J, Laakso M. OBESITY (SILVER SPRING, MD.) 15: 2902-2907. 2007

Single nucleotide polymorphisms of the melanocortin-3 receptor gene are associated with substrate oxidation and first-phase insulin secretion in offspring of type 2 diabetic subjects

Rutanen J, Pihlajamäki J, Vänttinen M, Salmenniemi U, Ruotsalainen E, Kuulasmaa T, Kainulainen S, Laakso M, Laakso M. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 92: 1112-1117. 2007

Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: executive summary: The Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC) and of the European Association for the Study of Diabetes (EASD)

Rydén L, Standl E, Bartnik M, Van den Berghe G, Betteridge J, de Boer MJ, Cosentino F, Jönsson B, Laakso M, Malmberg K, Priori S, Östergren J, Tuomilehto J, Thrainsdottir I, Vanhorebeek I, Stramba-Badiale M, Lindgren P, Qiao Q, Priori SG, Blanc JJ, Budaj A, Camm J, Dean V, Deckers J, Dickstein K, Lekakis J, Mcgregor K, Metra M, Morais J, Osterspey A, Tamargo J, Zamorano JL, Deckers JW, Bertrand M,. EUROPEAN HEART JOURNAL 28: 88-136. 2007

Association of C-reactive protein, interleukin-1 receptor antagonist and adiponectin with the metabolic syndrome

Saltevo J, Vanhala M, Kautiainen H, Kumpusalo E, Laakso M. MEDIATORS OF INFLAMMATION (ONLINE): Article ID 93573. 2007

Levels of adiponectin, C-reactive protein and interleukin-1 receptor antagonist are associated with the relative change in body mass index between childhood and adulthood

Saltevo J, Vanhala M, Kautiainen H, Laakso M. DIABETES AND VASCULAR DISEASE RESEARCH 4: 328-331. 2007

Cholesterol metabolism and non-cholesterol sterol distribution in lipoproreins of type 1 diabetes: The effect of improved glycemic control

Sittiwet C, Gylling H, Hallikainen M, Pihlajamäki J, Moilanen L, Laaksonen DE, Niskanen L, Ågren JJ, Laakso M, Miettinen TA. ATHEROSCLEROSIS 194: 465-472. 2007

Myocardial perfusion, oxidative metabolism, and free fatty acid uptake in patients with hypertrophic cardiomyopathy attributable to the Asp175Asn mutation in the alpha-tropomyosin gene: a positron emission tomography study

Tuunanen H, Kuusisto J, Toikka J, Jääskeläinen P, Marjamäki P, Peuhkurinen K, Viljanen T, Sipola P, Stolen KQ, Hannukainen J, Nuutila P, Laakso M, Knuuti J, Laakso M. JOURNAL OF NUCLEAR CARDIOLOGY 14 3: 354-365. 2007

Genetic variation within the APPL locus is not associated with metabolic or inflammatory traits in a healthy white population

Staiger H, Machicao F, Machann J, Schick F, Kuulasmaa T, Laakso M, Fritsche A, Stefan N, Häring H-U, Laakso M. DIABETIC MEDICINE 24: 817-822. 2007

Genetic variations in PPARD and PPARGC1A determine mitochondrial function and change in aerobic pysical fitness and insulin sensitivity during lifestyle intervention

Stefan N, Thamer C, Staiger H, Machicao F, Machann J, Shick F, Venter C, Niess A, Laakso M, Fritsche A, Häring H-U, Laakso M. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 92: 1827-1833. 2007

Diabeteksen Käypä hoito -suositus

Suomalaisen Lääkäriseuran Duodecimin, Diabetesliiton Lääkärineuvoston, ja Suomen Sisätautilääkärien Yhdistyksen Asettama Työryhmä, Laakso M, Louheranta A. DUODECIM 123: 1490-1520. 2007

Clustering of risk factors in parents of patients with type 1 diabetes and nephropathy

Thorn LM, Forsblom C, Fagerudd J, Pettersson-Fernholm K, Kilpikari R, Groop PH, on behalf of the FinnDiane Study Group, Huttunen E, Karhapää P, Laakso M, Moilanen L, Niskanen L, Vauhkonen I, Voutilainen E. DIABETES CARE 30: 1162-1167. 2007

Leisure-time physical activity is associated with the metaboic syndrome in type 1 diabetes: Effect of the PPAR-gamma Pro12Ala polymorphism: the FinnDiane Study

Wadén J, Thorn LM, Forsblom C, Lakka T, Saraheimo M, Rosengård-Bärlund M, Heikkilä O, Wessman M, Turunen JA, Parkkonen M, Tikkanen H, Groop P-H, on behalf of the FinnDiane Study Group. DIABETES CARE 30: 1618-1620. 2007

Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion

Wang J, Kuusisto J, Vänttinen M, Kuulasmaa T, Lindström J, Tuomilehto J, Uusitupa M, Laakso M, Laakso M. DIABETOLOGIA 50: 1192-1200. 2007

Metabolic syndrome and incident end-stage peripheral vascular disease. A 14-year follow-up study in elderly Finns

Wang J, Ruotsalainen S, Moilanen L, Lepistö P, Laakso M, Kuusisto J. DIABETES CARE 30: 3099-3104. 2007

The metabolic syndrome predicts cardiovascular mortality: a 13-year follow-up study in elderly non-diabetic Finns

Wang J, Ruotsalainen S, Moilanen L, Lepistö P, Laakso M, Kuusisto J. EUROPEAN HEART JOURNAL 28: 857-864. 2007

Challenges in studies of the genetic basis of type 2 diabetes

Laakso M. EXPERT REVIEW OF ENDOCRINOLOGY AND METABOLISM 2 4: 451-459. 2007

Prevention of cardiovascular events in diabetic patients

Laakso M. Fisher M, McMurray JJ, Diabetic Cardiology.John Wiley & Sons. 221-239. 2007

Effect of genotype on success of lifestyle intervention in subjects at risk for type 2 diabetes

Weyrich P, Stefan N, Häring H-U, Laakso M, Fritsche A. JOURNAL OF MOLECULAR MEDICINE 85: 107-117. 2007

Tyypin 2 diabeteksen ehkäisy

Laakso M, Uusitupa M. DUODECIM 123: 1439-1447. 2007

Increased atherosclerotic lesion calcification in a novel mouse model combining insulin resistance, hyperglycemia, and hypercholesterolemia

Heinonen SE, Leppänen P, Kholová I, Lumivuori H, Häkkinen S-K, Bosch F, Laakso M, Ylä-Herttuala S, Kholova I, Laakso M. CIRCULATION RESEARCH 101: 1058-1067. 2007

Single nucleotide polymorphisms of the peroxisome proliferator-activated receptor-alpha gene (PPARA) influence the conversion from impaired glucose tolerance to type 2 diabetes. The STOP-NIDDM Trial

Andrulionyté L, Kuulasmaa T, Chiasson J-L, Laakso M, for the STOPP-NIDDM Study Group, Laakso M. DIABETES (NY) 56: 1181-1186. 2007

Sirtuiinit - energiatasapainon ja glukoosimetabolian uudet molekyylit

Laakso M, Laakso M. DUODECIM 123: 2291-2292. 2007

Pioglitazone use and heart failure in patients with type 2 diabetes and preexisting cardiovascular disease. Data from the PROactive Study (PROactive 08)

Erdmann E, Charbonnel B, Wilcox RG, Skene AM, Massi-Benedetti M, Yates J, Tan M, Spanheimer R, Standl E, Dormandy JA, on behalf of the PROactive Investigators, Laakso M, Laakso M. DIABETES CARE 30: 2773-2778. 2007

The effect of pioglitazone on recurrent myocardial infaraction in 2,445 patients with type 2 diabetes and previous myocardial infarction

Erdmann E, Dormandy JA, Charbonnel B, Massi-Benedetti M, Moules IK, Skene AM, on behalf of the PROactive Investigators, Laakso M. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 49: 1772-80. 2007

Insulin resistance, insulin response, and obesity as indicators of metabolic risk

Ferrannini E, Balkau B, Coppack SW, Dekker JM, Mari A, Nolan J, Walker M, Natali A, Beck-Nielsen H, and the RISC investigators, Laakso M, Räisänen R, Ruotsalainen U, Laitinen M, Saloranta H. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 92: 2885-2892. 2007

Association of fasting glucagon and proinsulin concentrations with insulin resistance

Ferrannini E, Muscelli E, Natali A, Gabriel R, Mitrakou A, Flyvbjerg A, Golay A, Hojlund K, the Relationship between Insulin Sensitivity, Laakso M, Räisänen R, Ruotsalainen U, Laitinen M, Saloranta H. DIABETOLOGIA 50: 2342-2347. 2007

Phosphorylation barriers to skeletal and cardiac muscle glucose uptakes in high-fat-fed mice. Studies in mice with a 50 % reduction of hexokinase II

Fueger PT, Lee-Young RS, Shearer J, Bracy DP, Heikkinen S, Laakso M, Rottman JN, Wasserman DH. DIABETES (NY) 56: 2476-2484. 2007

Cholesterol synthesis prevails over absorption in metabolic syndrome

Gylling H, Hallikainen M, Kolehmainen M, Toppinen L, Pihlajamäki J, Mykkänen H, Ågren JJ, Rauramaa R, Laakso M, Miettinen TA. TRANSLATIONAL RESEARCH 149: 310-316. 2007

A common haplotype in the G-protein-coupled receptor gene GPR74 is associated with leanness and increased lipolysis

Dahlman I, Dicker A, Jiao H, Kere J, Blomqvist L, van Harmelen V, Hoffstedt J, Borch-Johnsen K, Jörgensen T, Hansen T, Pedersen O, Laakso M, Arner P, Laakso M. AMERICAN JOURNAL OF HUMAN GENETICS 80: 1115-1124. 2007

Retinopathy predicts cardiovascular mortality in type 2 diabetic men and women

Juutilainen A, Lehto S, Rönnemaa T, Pyörälä K, Laakso M. DIABETES CARE 30: 292-299. 2007

Atherosclerosis and cardiovascular risk reduction with PPAR agonists

Kuusisto J, Andrulionyte L, Laakso M, Laakso M. CURRENT ATHEROSCLEROSIS REPORTS 9: 274-280. 2007

Retinopathy predicts cardiovascular mortality in type 2 diabetic men and women

Juutilainen A, Lehto S, Rönnemaa T, Pyörälä K, Laakso M. DIABETES CARE 30: e52. 2007

Cerebrovascular disease in type 2 diabetes

Laakso M, Kuusisto J. Grepaldi G, Tiengo A, Avogaro A, The Metabolic Syndrome: The Road Map from Inflammation to Cardiovascular Disease. Proceedings ot the 9th European Symposium on Metabolism. International Congress Series. 65-69. 2007

Yksi, kaksi vai monta diabetesta?

Laakso M, Groop L. DUODECIM 123: 1427-1429. 2007

Diabetes - glukoosiaineenvaihdunnan säätelyn perinnöllinen häiriö

Laakso M, Laakso M. DUODECIM 123: 2195-2204. 2007

Habitual physical activity and vascular aging in a young to middle-age population at low cardiovascular risk

Kozakova M, Palombo C, Mhamdi L, Konrad T, Nilsson P, Staehr PB, Paterni M, Balkau B, on behalf of the RISC Investigators, Laakso M, Räisänen R, Ruotsalainen U, Laitinen M, Saloranta H. STROKE 38: 2549-2555. 2007

Physical activity modifies the effect of SNPs in the SLC2A2 (GLUT2) and ABCC8 (SUR1) genes on the risk of developing type 2 diabetes

Kilpeläinen TO, Lakka TA, Laaksonen DE, Laukkanen O, Lindström J, Eriksson JG, Valle TT, Hämäläinen H, Aunola S, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Uusitupa M, Laakso M, for the Finnish Diabetes Prevention Study Group, Laakso M. PHYSIOLOGICAL GENOMICS (PRINTED AND ONLINE) 31: 264-272. 2007

Increased serum levels of advanced glycation endproducts predict total, cardiovascular and coronary mortality in women with type 2 diabetes: a population-based 18 year follow-up study

Kilhovd BK, Juutilainen A, Lehto S, Rönnemaa T, Torjesen PA, Hanssen KF, Laakso M. DIABETOLOGIA 50: 1409-1417. 2007

Effect of fenofibrate on the need for treatment for diabetic retinopathy (FIELD study): a randomised controlled trial

Keech AC, Mitchell P, Summanen PA, O¿Day J, Davis TME, Moffitt MS, Taskinen M-R, Simes RJ, Tse D, Williamson E, Merrifield A, Laatikainen LT, d¿Emden MC, Crimert DC, O¿Connell RL, Colman PG, for the Field study investigators, Laakso M. LANCET 370: 1687-1697. 2007

Adiponectin gene haplotype is associated with preeclampsia

Saarela T, Hiltunen M, Helisalmi S, Heinonen S, Laakso M, Laakso M, Hiltunen M, Helisalmi S. GENETIC TESTING 10 1: 35-39. 2006

Noninvasive diagnosis of focal hyperinsulinism of infancy with [18F]-DOPA positron emission tomography

Otonkoski T, Näntö-Salonen K, Seppänen M, Veijola R, Huopio H, Hussain K, Tapanainen P, Eskola O, Parkkola R, Ekström K, Guiot Y, Rahier J, Laakso M, Rintala R, Nuutila P, Minn H. DIABETES (NY) 55: 13-18. 2006

Visceral obesity is associated with high levels of serum squalene

Peltola P, Pihlajamäki J, Koutnikova H, Ruotsalainen E, Salmenniemi U, Vauhkonen I, Kainulainen S, Gylling H, Miettinen TA, Auwerx J, Laakso M, Laakso M. OBESITY (SILVER SPRING, MD.) 14: 1155-1163. 2006

Common polymorphisms of calpain-10 are associated with abdominal obesity in subjects at high risk of type 2 diabetes

Pihlajamäki J, Salmenniemi U, Vänttinen M, Ruotsalainen E, Kuusisto J, Vauhkonen I, Kainulainen S, Ng MCY, Cox NJ, Bell CI, Laakso M, Laakso M. DIABETOLOGIA 49: 1560-1566. 2006

Diastolic dysfunction without left ventricular hypertrophy is an early finding in children with hypertrophic cardiomyopathy-causing mutations in the beeta-myosin heavy chain, alfa-tropomyosin, and myosin-binding protein C genes

Poutanen T, Tikanoja T, Jääskeläinen P, Jokinen E, Silvast A, Laakso M, Kuusisto J, Laakso M. AMERICAN HEART JOURNAL [ONLINE: HTTP:WWW.MOSBY.COM/AHJ] 151: 725.e1-725.e9. 2006

VEGF-A, VEGF-D, VEGF receptor-1, VEGF receptor-2, NF-kappaB, and RAGE in atherosclerotic lesions of diabetic Watanabe heritable hyperlipidemic rabbits [FJ Express Full-Length Article]

Roy H, Bhardwaj S, Babu M, Kokina I, Uotila S, Ahtialansaari T, Laitinen T, Hakumaki J, Laakso M, Herzig K-H, Ylä-Herttuala S. FASEB JOURNAL [ONLINE] 20: E1550-E1559. 2006

VEGF-A, VEGF-D, VEGF receptor-1, VEGF receptor-2, NF-kappaB, and RAGE in atherosclerotic lesions of diabetic Watanabe heritable hyperlipidemic rabbits

Roy H, Bhardwaj S, Babu M, Kokina I, Uotila S, Ahtialansaari T, Laitinen T, Hakumäki J, Laakso M, Herzig K-H, Ylä-Herttuala S. FASEB JOURNAL 20: 2159-2161. 2006

Changes in inflammatory cytokines are related to impaired glucose tolerance in offspring of type 2 diabetic subjects

Ruotsalainen E, Salmenniemi U, Vauhkonen I, Pihlajamäki J, Punnonen K, Kainulainen S, Laakso M. DIABETES CARE 29 12: 2714-2720. 2006

Pathogenesis and treatment of diabetic vascular disease - illustrated by two cases

Smith U, Laakso M, Eliasson B, Wesslau C, Borén J, Wiklund O, Attvall S. JOURNAL OF INTERNAL MEDICINE 260: 409-420. 2006

Plasma cell membrane glycoprotein-1 K121Qmpolymorphism in preeclampsia

Saarela T, Hiltunen M, Helisalmi S, Heinonen S, Laakso M, Laakso M, Hiltunen M, Helisalmi S. GYNECOLOGIC AND OBSTETRIC INVESTIGATION 61: 124-127. 2006

Polymorphisms of interleukin-6, hepatic lipase and calpain-10 genes, and preeclampsia

Saarela T, Hiltunen M, Helisalmi S, Heinonen S, Laakso M, Laakso M, Hiltunen M, Helisalmi S. EUROPEAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND REPRODUCTIVE BIOLOGY 128: 175-179. 2006

Association of sequence variations in the gene encoding adoponectin receptor 1 (ADIPOR1) with body size and insulin levels. The Finnish diabetes prevention study

Siitonen N, Pulkkinen L, Mager U, Lindström J, Eriksson JG, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Laakso M, Uusitupa M, for the Finnish diabetes prevention study group, Siitonen N, Pulkkinen L, Mager U. DIABETOLOGIA 49: 1795-1805. 2006

Myocardial late gadolinium enhancement is associated with raised serum amino-terminal propeptide of type III collagen concentrations in patients with hypertrophic cardiomyopathy attributable to the Asp175Asn mutation in the alpha tropomyosin gene:

Sipola P, Peuhkurinen K, Lauerma K, Husso M, Jääskeläinen P, Laakso M, Aronen HJ, Risteli J, Kuusisto J, Laakso M. HEART 92: 1321-1322. 2006

High-sensitivity C-reactive protein and coronary heart disease mortality in patients with type 2 diabetes: a 7-year follow-up study

Soinio M, Marniemi J, Laakso M, Lehto S, Rönnemaa T. DIABETES CARE 29: 329-333. 2006

Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial

The DREAM Trial Investigators, Laakso M, Rutanen J, Jantunen A. LANCET 368: 1096-1105. 2006

Effect of ramipril on the incidence of diabetes

The DREAM Trial Investigators, Laakso M. NEW ENGLAND JOURNAL OF MEDICINE 355: 1551-1562. 2006

Association of metabolic syndrome with Alzheimer disease: a population-based study

Vanhanen M, Koivisto K, Moilanen L, Helkala E-L, Hänninen T, Soininen H, Kervinen K, Kesäniemi YA, Laakso M, Kuusisto J, Soininen H. NEUROLOGY 67: 843-847. 2006

Mice with targeted disruption of spermidine/spermine N1-acetyltransferese gene maintain nearly normal tissue polyamine homeostasis but show signs of insulin resistance upon aging

Niiranen K, Keinänen TA, Pirinen E, Heikkinen S, Tusa M, Fatrai S, Suppola S, Pietilä M, Uimari A, Laakso M, Alhonen L, Jänne J. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 10: 933-945. 2006

The pro12Ala polymorphism of the PPAR gamma 2 gene influences sex hormone binding globulin level and its relationship to the development of the metabolic syndrome in young Finnish men

Mousavinasab F, Tähtinen T, Jokelainen J, Koskela P, Vanhala M, Oikarinen J, Laakso M, Keinänen-Kiukaanniemi S. ENDOCRINE 30: 185-190. 2006

Common polymorphisms (single-nucleotide polymorphisms SNP+45 and SNP+276) of the adiponectin gene regulate serum adiponectin concentrations and blood pressure in young Finnish men

Mousavinasab F, Tähtinen T, Jokelainen J, Koskela P, Vanhala M, Oikarinen J, Keinänen-Kiukaanniemi S, Laakso M, Laakso M. MOLECULAR GENETICS AND METABOLISM (ARLANDO) 87: 147-151. 2006

Gene dose effect of the DQB1*0201 allele contributes to severity of coeliac disease

Karinen H, Kärkkäinen P, Pihlajamäki J, Janatuinen E, Heikkinen M, Julkunen R, Kosma V-M, Naukkarinen A, Laakso M. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY 41: 191-199. 2006

Association of the Leu72Met polymorphism of the ghrelin gene with the risk of type 2 diabetes in subjects with impaired glucose tolerance in the Finnish diabetes prevention study

Mager U, Lindi V, Lindström J, Eriksson JG, Vallet TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Laakso M, Pulkkinen L, Uusitupa M, for the Finnish diabetes prevention study group, Mager U, Lindi V, Pulkkinen L. DIABETIC MEDICINE 23: 685-689. 2006

Single nucleotide polymorphisms of the HNF4alfa gene are associated with the conversion to type 2 diabetes mellitus: the STOP-NIDDM trial

Andrulionyté L, Laukkanen O, Chiasson J-L, Laakso M, STOP-NIDDM Study Group, Laakso M. JOURNAL OF MOLECULAR MEDICINE 84: 701-708. 2006

Single nucleotide polymorphisms of PPARD in combination with the Gly482Ser substitution of PGC-1A and the Pro12Ala substitution of PPARG2 predict the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM Trial

Andrulionyté L, Peltola P, Chiasson J-L, Laakso M, for the STOP-NIDDM Study Group. DIABETES (NY) 55: 2148-2152. 2006

Low birth weight does not increase the risk of nephropathy in Finnish type 1 diabetic patients

Fagerudd J, Forsblom C, Pettersson-Fernholm K, Saraheimo M, Wadén J, Rönnback M, Rosengård-Bärlund M, af Björkesten C-G, Thorn L, Wessman M, Groop P-H, on behalf of the FinnDiane Study Group, Laakso M, Karhapää P, Mykkänen L, Niskanen L, Vauhkonen I. NEPHROLOGY, DIALYSIS, TRANSPLANTATION 21: 2159-2165. 2006

Interaction of the - 308G/A promoter polymorphism of the tumor necrosis factor-alfa gene with single-nucleotide polymorphism 45 of the adiponectin gene: effect on serum adiponectin concentrations in a Spanish population

González-Sánchez JL, Martínez-Calatrava MJ, Martínez-Larrad MT, Zabena C, Fernández-Pérez C, Laakso M, Serrano-Ríos M, Laakso M. CLINICAL CHEMISTRY 52: 97-103. 2006

Proteinuria and metabolic syndrome as predictors of cardiovascular death in non-diabetic and type 2 diabetic men and women

Juutilainen A, Lehto S, Rönnemaa T, Pyörälä K, Laakso M. DIABETOLOGIA 49: 56-65. 2006

HLA genotyping is useful in the evaluation of the risk for coelic disease in the 1st-degree relatives of patients with coeliac disease

Karinen H, Kärkkäinen P, Pihlajamäki J, Janatuinen E, Heikkinen M, Julkunen R, Kosma V-M, Naukkarinen A, Laakso M, Laakso M. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY 41: 1299-1304. 2006

Visfatin is an adipokine, but it is not regulated by Thiazolidinediones

Hammarstedt A, Pihlajamäki J, Sopasakis VR, Gogg S, Jansson P-A, Laakso M, Smith U. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 91: 1181-1184. 2006

Correction to the FIELD study report

Keech A, Simes J, Barter P, Best J, Scott R, Taskinen M-R, on behalf of the FIELD Management Committee, Laakso M. LANCET 368: 1415. 2006

Novel mutations in the lamin A/C gene in heart transplant recipients with end stage dilated cardiomyopathy

Kärkkäinen S, Reissell E, Heliö T, Kaartinen M, Tuomainen P, Toivonen L, Kuusisto J, Kupari M, Nieminen MS, Laakso M, Peuhkurinen K, Laakso M. HEART 92: 524-526. 2006

Metabolic syndrome: To be or not to be?

Laakso M, Kovanen PT. Annals of Medicine 38: 32-33. 2006

Metformiini: vanha lääke, uusi vaikutusmekanismi

Laakso M. DUODECIM 122: 1563-1564. 2006

Mutations in the PPARgamma gene relevant for diabetes and the metabolic syndrome

Laakso M. Brigelius-Flohé R, Joost H-G, Nutritional Genomics. Impact on Health and Disease.Wiley. 195-207. 2006

Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha

Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, Messadeq N, Milne J, Lambert P, Elliot P, Geny B, Laakso M, Puigserver P, Auwerx J, Laakso M. CELL 127: 1109-1122. 2006

Association analysis of peroxisome proliferator-activated receptor gamma polymorphisms and late onset Alzhimer¿s disease in the Finnish population

Koivisto AM, Helisalmi S, Pihlajamäki J, Hiltunen M, Koivisto K, Moilanen L, Kuusisto J, Helkala E-L, Hänninen T, Kervinen K, Kesäniemi YA, Laakso M, Soininen H, Koivisto AM, Helisalmi S, Hiltunen M, Soininen H, Laakso M. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS 22: 449-453. 2006

Autosomissa vallitsevasti periytyvä munuaisten monirakkulatauti

Lumiaho A, Laakso M. DUODECIM 122: 200-207. 2006

Genetic variation in leptin receptor gene is associated with type 2 diabetes and body weight: The Finnish diabetes prevention study

Salopuro T, Pulkkinen L, Lindström J, Eriksson JG, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Laakso M, Uusitupa M, for the Finnish Diabetes Prevention Study Group, Salopuro T, Pulkkinen L, Uusitupa M, Laakso M. INTERNATIONAL JOURNAL OF OBESITY 29: 1245-1251. 2005

Increased levels of mannan-binding lectin in type 1 diabetic patients with incipient and overt nephropathy

Saraheimo M, Forsblom C, Hansen TK, Teppo A-M, Fagerudd J, Pettersson-Fernholm K, Thiel S, Tarnow L, Ebeling P, Flyvbjerg A, Groop P-H, on behalf of the FinnDiane Study Group, Laakso M, Niskanen L, Vauhkonen I, Voutilainen E, Mykkänen L, Karhapää P. DIABETOLOGIA 48: 198-202. 2005

Serum adiponectin in increased in type 1 diabetic patients with nephropathy

Saraheimo M, Forsblom C, Fagerudd J, Teppo A-M, Pettersson-Fernholm K, Frystyk J, Flyvbjerg A, Groop P-H, on behalf of the FinnDiane Study Group, Laakso M, Niskanen L, Vauhkonen I, Voutilainen E, Mykkänen L, Karhapää P, Huttunen E. DIABETES CARE 28: 1410-1414. 2005

Long-term effects of pioglitazone and metformin on insulin sensitivity in patients with type 2 diabetes mellitus

Roden M, Laakso M, Johns D, Widel M, Urquhart R, Richardson C, Mariz S, Tan MH. DIABETIC MEDICINE 22: 1101-1106. 2005

Association of adiponectin level and variants in the adiponectin gene with glucose metabolism, energy expenditure, and cytokines in offspring of type 2 diabetic patients

Salmenniemi U, Zacharova J, Ruotsalainen E, Vauhkonen I, Pihlajamäki J, Kainulainen S, Punnonen K, Laakso M, Laakso M. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 90: 4216-4223. 2005

High amount of visceral fat mass is associated with multiple metabolic changes in offspring of type 2 diabetic patients

Salmenniemi U, Ruotsalainen E, Vänttinen M, Vauhkonen I, Pihlajamäki J, Kainulainen S, Punnonen K, Laakso M. INTERNATIONAL JOURNAL OF OBESITY 29: 1464-1470. 2005

Tumour necrosis factor-alpha gene haplotype is associated with pre-eclampsia

Saarela T, Hiltunen M, Helisalmi S, Heinonen S, Laakso M. MOLECULAR HUMAN REPRODUCTION 11 6: 437-440. 2005

Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial

The Field study investigators, Laakso M, Jantunen A, Kähkönen H, Kortelainen S, Koukkunen H, Laitinen M, Lehto S, Lehto R, Lumiaho A. LANCET 366: 1849-1861. 2005

Cine MR imaging of myocardial contractile impairment in patients with hypertrophic cardiomyopathy attributable to Asp175Asn mutation in the alpha-tropomyosin gene

Sipola P, Lauerma K, Jääskeläinen P, Laakso M, Peuhkurinen K, Manninen H, Aronen HJ, Kuusisto J, Laakso M. RADIOLOGY 236: 815- 824. 2005

The G-250A substitution in the promoter region of the hepatic lipase gene is associated with the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial

Zacharova J, Todorova BR, Chiasson J-L, Laakso M, for the STOP-NIDDM Study Group, Laakso M. JOURNAL OF INTERNAL MEDICINE 257: 185-193. 2005

Fenofibrate intervention and event lowering in diabetes (FIELD) study: baseline characteristics and short-term effects of fenofibrate [ISRCTN64783481]

The FIELD Study Investigators, Laakso M, Kortelainen S, Koukkunen H, Lehto S, Lehto R, Lumiaho A, Ruotsalainen S. CARDIOVASCULAR DIABETOLOGY [ONLINE: HTTP://WWW.CARDIAB.COM/] 4: article 13 [9 p.]. 2005

Metabolic syndrome in type 1 diabetes: association with diabetic nephropathy and glycemic control (the FinnDiane study)

Thron LM, Forsblom C, Fagerudd J, Thomas MC, Pettersson-Fernholm K, Saraheimo M, Wadén J, Rönnback M, Rosengård-Bärlund M, af Björkesten C-G, Taskinen M-R, Groop P-H, on behalf of the FinnDiane Study Group, Laakso M, Niskanen L, Mykkänen L. DIABETES CARE 28: 2019-2024. 2005

Subtle hyperproinsulinaemia characterises the defective insulin secretory capacity in offspring of glutamic acid decarboxylase antibody-positive patients with latent autoimmune diabetes mellitus in adults

Vauhkonen I, Niskanen L, Knip M, Moilanen Mykkänen L, Uusitupa M, Laakso M. EUROPEAN JOURNAL OF ENDOCRINOLOGY 153: 265-273. 2005

Single nucleotide polymorphisms in the peroxisome proliferator-activated receptor delta gene are associated with skeletal muscle glucose uptake

Vänttinen M, Nuutila P, Kuulasmaa T, Pihlajamäki J, Hällsten K, Virtanen KA, Lautamäki R, Peltoniemi P, Takala T, Viljanen APM, Knuuti J, Laakso M, Laakso M. DIABETES (NY) 54: 3587-3591. 2005

The effect of the Ala12 allele of the peroxisome proliferator-activated receptor-gamma2 gene on skeletal muscle glucose uptake depends on obesity: a positron emission tomography study

Vänttinen M, Nuutila P, Pihlajamäki J, Hällsten K, Virtanen KA, Lautamäki R, Peltoniemi P, Kemppainen J, Takala T, Viljanen APM, Knuuti J, Laakso M, Laakso M. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 90: 4249-4254. 2005

Effect of the interleukin-6 (-174) G/C promoter polymorphism on adiponectin and insulin sensitivity

Yang X, Jansson P-A, Pellmé F, Laakso M, Smith U, Laakso M. OBESITY (SILVER SPRING, MD.) 13: 813-817. 2005

Leptin receptor gene variation predicts weight change in subjects with impaired glucose tolerance

Zacharova J, Chiasson J-L, Laakso M, for the STOP-NIDDM Study Group, Laakso M. OBESITY (SILVER SPRING, MD.) 13: 501-506. 2005

The common polymorphisms (single nucleotide polymorphism [SNP] +45 and SNP +276) of the adiponectin gene predict the conversion from impaired glucose tolerance to type 2 diabetes: The STOPP-NIDDM trial

Zacharova J, Chiasson J-L, Laakso M, for the STOP-NIDDM Study Group, Laakso M. DIABETES (NY) 54: 893-899. 2005

Haplotypes of PPARGC1A are associated with glucose tolerance, body mass index and insulin sensitivity in offpring of patients with type 2 diabetes

Pihlajamäki J, Kinnunen M, Ruotsalainen E, Salmenniemi U, Vauhkonen I, Kuulasmaa T, Kainulainen S, Laakso M, Laakso M. DIABETOLOGIA 48: 1331-1334. 2005

A 100-kDa urinary protein is associated with insulin resistance in offspring of type 2 diabetic patients

Pätäri A, Karhapää P, Taipale H, Salmenniemi U, Ruotsalainen E, Vanninen P, Holthöfer H, Laakso M. DIABETOLOGIA 48: 1844-1850. 2005

Polymorphisms in the SLC2A2 (GLUT2) gene are associated with the conversation from impaired glucose tolerance to type 2 diabetes.The Finnish diabetes prevention study

Laukkanen O, Lindström J, Eriksson J, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Uusitupa M, Laakso M, Laakso M. DIABETES (NY) 54: 2256-2260. 2005

Genetics and phenotypic characteristics of autosomal dominant polycystic kidney disease in Finns

Peltola P, Lumiaho A, Miettinen R, Pihlajamäki J, Sandford R, Laakso M, Laakso M. JOURNAL OF MOLECULAR MEDICINE 83: 638-646. 2005

Type 2 diabetes as a "coronary heart diasease equivalent". An 18-year prospective population-based study in Finnish subjects

Juutilainen A, Lehto S, Rönnemaa T, Pyörälä K, Laakso M. DIABETES CARE 28: 2901-2907. 2005

High-dose atorvastatin vs usual-dose simvastatin for secondary prevention after myocardial infarction. The IDEAL study: A randomized controlled trial

Pedersen TR, Faergeman O, Kastelein JJP, Olsson AG, Tikkanen MJ, Holme I, Lytken Larsen M, Bendiksen FS, Lindahl C, Szarek M, Tsai J, for the IDEAL Study Group, Laakso M, Lehto S, Gylling H. JAMA - JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 294: 2437-2445. 2005

The CIDEA gene V115F polymorphism is associated with obesity in Swedish subjects

Dahlman I, Kaaman M, Jiao H, Kere J, Laakso M, Arner P, Laakso M. DIABETES (NY) 54: 3032-3034. 2005

Islet amyloid polypeptide gene promoter polymorphisms are not associated with type 2 diabetes or with the severity of islet amyloidosis

Esapa C, Moffitt JH, Novials A, McNamara CM, Levy JC, Laakso M, Gomis R, Clark A. BIOCHIMICA ET BIOPHYSICA ACTA 1740: 74-78. 2005

Polymorphisms in the gene encoding angiotensin I converting enzyme 2 and diabetic nephropathy

Fröjdö S, Sjölind L, Parkkonen M, Mäkinen V-P, Kilpikari R, Pettersson-Fernholm K, Forsblom C, Fagerudd J, Tikellis C, Cooper ME, Wessman M, Groop P-H, FinnDiane Study Group. DIABETOLOGIA 48: 2278-2281. 2005

Hexokinase II protein content is a determinant of exercise endurance capacity in the mouse

Fueger PT, Shearer J, Krueger TM, Posey KA, Bracy DP, Heikkinen S, Laakso M, Rottman JN, Wasserman DH. JOURNAL OF PHYSIOLOGY (CAMBRIDGE) 566 2: 533-541. 2005

An SNP in the adiponectin gene is associated with decreased serum adiponectin levels and risk for impaired glucose tolerance

González-Sánchez JL, Zabena CA, Martínez-Larrad MT, Fernández-Pérez C, Pérez-Barba M, Laakso M, Serrano-Ríos M, Laakso M. OBESITY (SILVER SPRING, MD.) 13: 807-812. 2005

Associations between two single nucleotide polymorphism in the adiponectin gene and polycystic ovary syndrome

Heinonen S, Korhonen S, Helisalmi S, Koivunen R, Tapanainen J, Hippeläinen M, Laakso M. GYNECOLOGICAL ENDOCRINOLOGY 21 3: 165-169. 2005

Synnynnäinen hyperinsulinismi

Huopio H, Laakso M, Otonkoski T. DUODECIM 121: 1166-1175. 2005

Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial

Dormandy JA, Charbonnel B, Eckland DJA, Erdmann E, Massi-Benedetti M, Moules IK, Skene AM, Tan MH, Lefèbvre PJ, Murray GD, Standl E, Wilcox RG, Wilhelmsen L, Betteridge J, Birkeland K, Golay A, Heine RJ, Korányi L, Laakso M, Mokán M, Norkus A, Pirags V, Podar T, Scheen A, Scherbaum W, Schernthaner G, Schmitz O, Skrha J, Smith U, Taton J, on behalf of the PROactive investigators. LANCET 366: 1279-1289. 2005

High serum levels of advanced glycation end products predict increased coronary heart disease mortality in nondiabetic women but not in nondiabetic men. A population-based 18-year follow-up study

Kilhovd BK, Juutilainen A, Lehto S, Rönnemaa T, Torjesen PA, Birkeland KI, Berg TJ, Hanssen KF, Laakso M. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 25: 815-820. 2005

Insulin resistance and coronary heart disease

Laakso M, Kuusisto J. Serrano Ríos M, Caro JF, Carraro R, Gutiérrez Fuentes JA, The Metabolic Syndrome at the Beginning of the XXIst Century.Elsevier. 369-382. 2005

Metabolisen oireyhtymän uudet kriteerit ja hoito

Laakso M. DUODECIM 121: 1521-1530. 2005

Prevention of type 2 diabetes

Laakso M. CURRENT MOLECULAR MEDICINE 5: 365-374. 2005

Lipids and glucose in type 2 diabetes: what about the beta-cell and the mitochondria? Response to Eldor and Raz

Boden G, Laakso M. DIABETES CARE 28: 986-987. 2005

Prognostic risk of atrial fibrillation in acute myocardial infarction complicated by left ventricular dysfunction: the OPTIMAAL experience

Lehto M, Snapinn S, Dickstein K, Swedberg K, Nieminen M, on behalf of the OPTIMAAL investigators, Laakso M, Lehto S. EUROPEAN HEART JOURNAL 26: 350-356. 2005

Autoantibodies against oxidized LDL are associated with severe chest pain attacks in patients with coronary heart disease

Luoma JS, Kareinen A, Närvänen O, Viitanen L, Laakso M, Ylä-Herttuala S. FREE RADICAL BIOLOGY & MEDICINE 39: 1660-1665. 2005

Intense metabolic control by means of insulin in patients with diabetes mellitus and acute myocardial infarction (DIGAMI ): effects on mortality and morbidity

Malmberg K, Rydén L, Wedel H, Birkeland K, Bootsma A, Dickstein K, Efendic S, Fisher M, Hamsten A, Herlitz J, Hildebrandt P, MacLeod K, Laakso M, Torp-Pedersen C, Waldenström A, for the DIGAMI 2 Investigators. EUROPEAN HEART JOURNAL 26: 650-661. 2005

Effect of the Pro12Ala polymorphism of the PPARgamma2 gene on serum adiponectin changes

Mousavinasab F, Tähtinen T, Jokelainen J, Koskela P, Vanhala M, Oikarinen J, Keinänen-Kiukaanniemi S, Laakso M, Laakso M. ENDOCRINE 27: 307-309. 2005

Common polymorphisms in the PPARgamma2 and IRS-1 genes and their interaction influence serum adiponectin concentration in young Finnish men

Mousavinasab F, Tähtinen T, Jokelainen J, Koskela P, Vanhala M, Oikarinen J, Keinänen-Kiukaanniemi S, Laakso M, Laakso M. MOLECULAR GENETICS AND METABOLISM (ARLANDO) 84: 344-348. 2005

Multiple abnormalities in glucose and energy metabolism and coordinated changes in levels of adiponectin, cytokines, and adhesion molecules in subjects with metabolic syndrome

Salmenniemi U, Ruotsalainen E, Pihlajamäki J, Vauhkonen I, Kainulainen S, Punnonen K, Vanninen E, Laakso M. CIRCULATION 110: 3842-3848. 2004

The Pro12Ala polymorphism of the PPARgamma2 gene regulates weight from birth to adulthood

Pihlajamäki J, Vanhala M, Vanhala P, Laakso M, Laakso M. OBESITY (SILVER SPRING, MD.) 12 2: 187-190. 2004

The Val103Ile polymorphism of melanocortin-4 receptor regulates energy expenditure and weight gain

Rutanen J, Pihlajamäki J, Karhapää P, Vauhkonen I, Kuusisto J, Moilanen Mykkänen L, Laakso M, Laakso M. OBESITY (SILVER SPRING, MD.) 12: 1060-1066. 2004

Genomewide search and association studies in a Finnish celiac disease population: identification of a novel locus and replication of HLA and CTLA4 loci

Rioux JD, Karinen H, Kocher K, McMahon SG, Kärkkäinen P, Janatuinen E, Heikkinen M, Julkunen R, Pihlajamäki J, Naukkarinen A, Kosma V-M, Daly MJ, Lander ES, Laakso M, Laakso M. AMERICAN JOURNAL OF MEDICAL GENETICS. PART A 130: 345-350. 2004

Analysis of the human hexokinase II promoter in vivo: lack of insulin response within 4.0 kb

Pirinen E, Heikkinen S, Malkki M, Deep SS, Jänne J, Laakso M. BIOCHIMICA ET BIOPHYSICA ACTA - GENE STRUCTURE AND EXPRESSION 1676: 149-154. 2004

Association between a deletion/insertion polymorphism in the alfa2B-adrenergic receptor gene and insulin secretion and type 2 diabetes. The Finnish diabetes prevention study

Siitonen N, Lindström J, Eriksson J, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Laakso M, Uusitupa M. DIABETOLOGIA 47: 1416-1424. 2004

Common variants in beta2- and beta3-adrenergic receptor genes and uncoupling protein 1 as predictors of the risk for type 2 diabetes and body weight changes. The Finnish diabetes prevention study

Salopuro T, Lindström J, Eriksson JG, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Laakso M, Uusitupa M, Finnish Diabetes Preventio Study Group. CLINICAL GENETICS (COPENHAGEN) 66: 365-367. 2004

Rationale, design and recruitment characteristics of a large, simple international trial of diabetes prevention: the DREAM trial

The DREAM Trial Investigators, Laakso M, Sivenius K. DIABETOLOGIA 47: 1519-1527. 2004

Aldose reductase gene polymorphisms and susceptibility to microvascular complications in type 2 diabetes

Sivenius K, Niskanen L, Voutilainen-Kaunisto R, Laakso M, Uusitupa M. DIABETIC MEDICINE 21: 1325-1333. 2004

Aldose reductase gene polymorphisms and peripheral nerve function in patients with type 2 diabetes

Sivenius K, Pihlajamäki J, Partanen J, Niskanen L, Laakso M, Uusitupa M. DIABETES CARE 27: 2021-2026. 2004

Elevated plasma homocysteine level is an independent predictor of coronary heart disease events in patients with type 2 diabetes mellitus

Soinio M, Marniemi J, Laakso M, Lehto S, Rönnemaa T. ANNALS OF INTERNAL MEDICINE 140 2: 94-100. 2004

Ala12Ala genotype of the peroxisome proliferator-activated receptor gamma2 protects against atherosclerosis

Temelkova-Kurktschiev T, Hanefeld M, Chinetti G, Zawadzki C, Haulon S, Kubaszek A, Koehler C, Leonhardt W, Staels B, Laakso M, Laakso M. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 89 9: 4238-4242. 2004

The need for a large-scale trial of fibrate therapy in diabetes: the rationale and design of the Fenofibrate Intervention and Event Lowering in Diabets (FIELD) study. [ISRCTN64783481]

The FIELD Study Investigators, Laakso M. CARDIOVASCULAR DIABETOLOGY [ONLINE: HTTP://WWW.CARDIAB.COM/] 3: [11 p.]. 2004

The G-250A promoter polymorphism of the hepatic lipase gene predicts the conversion from impaired glucose tolerance to type 2 diabetes mellitus: the Finnish Diabetes Prevention Study

Todorova B, Kubaszek A, Pihlajamäki J, Lindström J, Eriksson J, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Uusitupa M, Laakso M, Laakso M. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 89 5: 2019-2023. 2004

Interactions between peroxisome proliferator-activated receptor-gamma 2 gene polymorphisms and size at birth on blood pressure and the use of antihypertensive medication

Yliharsila H, Eriksson JG, Forsen T, Laakso M, Uusitupa M, Osmond C, Barker DJ, Laakso M. JOURNAL OF HYPERTENSION 22 7: 1283-1287. 2004

Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1)

Pajukanta P, Lilja HE, Sinsheimer JS, Cantor RM, Lusis AJ, Gentile M, Duan XJ, Soro-Paavonen A, Naukkarinen J, Saarela J, Laakso M, Ehnholm C, Taskinen M-R, Peltonen L. NATURE GENETICS 36: 371-376. 2004

Insulin resistance is associated with increased cholesterol synthesis and decreased cholesterol absorption in normoglycemic men

Pihlajamäki J, Gylling H, Miettinen TA, Laakso M. JOURNAL OF LIPID RESEARCH 45: 507-512. 2004

Dyslipidemiat

Suomen Sisätautilääkärien Yhdistys ry:n asettama työryhmä, Gylling H, Uusitupa M, Laakso M. DUODECIM 120: 1794-1816. 2004

Polymorphisms of the SUR1 (ABCC8) and Kir6.2 (KCNJ11) genes predict the conversion from impaired glucose tolerance to type 2 diabetes. The Finnish diabetes prevention study

Laukkanen O, Pihlajamäki J, Lindström J, Eriksson J, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Uusitupa M, Laakso M, for the Finnish diabetes prevention study group. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 89: 6286-6290. 2004

The 121Q allele of the plasma cell membrane glycoprotein 1 gene predisposes to polycystic ovary syndrome

Heinonen S, Korhonen S, Helisalmi S, Koivunen R, Tapanainen JS, Laakso M, Laakso M. FERTILITY AND STERILITY 82 3: 743-745. 2004

Common polymorphisms in the genes regulating the early insulin signalling pathway: effects on weight change and the conversion from impaired glucose tolerance to Type 2 diabetes

Laukkanen O, Pihlajamäki J, Lindström J, Eriksson J, Valle TT, Hämaläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Uusitupa M, Laakso M, for the Finnish Diabetes Prevention Study Group, Laakso M. DIABETOLOGIA 47: 871-877. 2004

Lipids and glucose in type 2 diabetes: what is the cause and effect?

Boden G, Laakso M. DIABETES CARE 27 9: 2253-2259. 2004

The prospective pioglitazone clinical trial in macrovascular events (PROactive): can pioglitazone reduce cardiovascular events in diabetes? Study design and baseline characteristics of 5238 patients

Charbonnel B, Dormandy J, Erdmann E, Massi-Benedetti M, Skene A, on behalf of the PROactive Study Group, Laakso M. DIABETES CARE 27: 1647-1653. 2004

Acarbose for the prevention of Type 2 diabetes, hypertension and cardiovascular disease in subjects with impaired glucose tolerance: facts and interpretations concerning the critical analysis of the STOP-NIDDM Trial data

Chiasson J-L, Josse RG, Gomis R, Hanefeld M, Karasik A, Laakso M, and the STOP-NIDDM Trial Research Group. DIABETOLOGIA 47 6: 969-975. 2004

Severe persistent hyperinsulinemic hypoglycemia due to a de novo glucokinase mutation

Cuesta-Munoz AL, Huopio H, Otonkoski T, Gomez-Zumaquero JM, Näntö-Salonen K, Rahier J, Lopez-Enriquez S, Garcia-Gimeno MA, Sanz P, Soriguer FC, Laakso M, Laakso M. DIABETES (NY) 53: 2164-2168. 2004

Polymorphisms in the ABCG5 and ABCG8 genes associate with cholesterol absorbtion and insulin sensitivity

Gylling H, Hallikainen M, Pihlajamäki J, Ågren J, Laakso M, Rajaratnam RA, Rauramaa R, Miettinen TA, Laakso M. JOURNAL OF LIPID RESEARCH 45: 1660-1665. 2004

Inducibility of life-threatening ventricular arrhythmias is related to maximum left ventricular thickness and clinical markers of sudden cardiac death in patients with hypertrophic cardiomyopathy attridutable to the Asp175Asn mutation in the Alfa-tropomyo

Hedman A, Hartikainen J, Vanninen E, Laitinen T, Jääskeläinen P, Laakso M, Peuhkurinen K, Kuusisto J, Laakso M. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 36: 91-99. 2004

Common polymorphisms of the PPAR-gamma2 (Pro12Ala) and PGC-1alpha (Gly482Ser) genes are associated with the conversion from impaired glucose tolerance to type 2 diabetes in the STOP-NIDDM trial

Andrulionyte L, Zacharova J, Chiasson JL, Laakso M, for the STOP-NIDDM Study Group. DIABETOLOGIA 47: 2176-2184. 2004

The EGIR-RISC Study (The European group for the study of insulin resistance: relationship between insulin sensitivity and cardiovascular disease risk): I. Methodology and objectives

Hills SA, Balkau B, Coppack SW, Dekker JM, Mari A, Natali A, Walker M, Ferrannini E, Report prepared on behalf of the EGIR-RISC Study Group, Laakso M, Aura A, Raisanen R, Ruotsalainen U, Sistonen T, Laitinen M. DIABETOLOGIA 47: 566-570. 2004

Genetics of hypertrophic cardiomyopathy in eastern Finland: few founder mutations with benign or intermediary phenotypes

Jääskeläinen P, Miettinen R, Kärkkäinen P, Toivonen L, Laakso M, Kuusisto J. ANNALS OF MEDICINE (HELSINKI) 36: 23-32. 2004

The association of the K121Q polymorphism of the plasma cell glycoprotein-1 gene with type 2 diabetes and hypertension depends on size at birth

Kubaszek A, Markkanen A, Eriksson JG, Forsen T, Osmond C, Barker DJ, Laakso M, Laakso M. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 89: 2044-2047. 2004

Two novel mutations in the beta-myosin heavy chain gene associated with dilated cardiomyopathy

Kärkkäinen S, Heliö T, Jääskeläinen P, Miettinen R, Tuomainen P, Ylitalo K, Kaartinen M, Reissell E, Toivonen L, Nieminen MS, Kuusisto J, Laakso M, Peuhkurinen K. EUROPEAN JOURNAL OF HEART FAILURE 6: 861-868. 2004

A novel mutation, Ser143Pro, in the lamin A/C gene is common in finnish patients with familial dilated cardiomyopathy

Kärkkäinen S, Heliö T, Miettinen R, Tuomainen P, Peltola P, Rummukainen J, Ylitalo K, Kaartinen M, Kuusisto J, Toivonen L, Nieminen MS, Laakso M, Peuhkurinen K, Laakso M. EUROPEAN HEART JOURNAL 25 10: 885-893. 2004

Gene variants, insulin resistance, and dyslipidaemia

Laakso M. CURRENT OPINION IN LIPIDOLOGY 15: 115-120. 2004

The relative importance of cardiovascular risk factors in type 2 diabetic

Laakso M. INTERNATIONAL JOURNAL OF CLINICAL PRACTICE. SUPPLEMENT 58 124: 20-24. 2004

Gender difference in the impact of type 2 diabetes on coronary heart disease risk

Juutilainen A, Kortelainen S, Lehto S, Rönnemaa T, Pyörälä K, Laakso M. DIABETES CARE 27: 2898-2904. 2004

Combined analysis of genome scans of Dutch and Finnish families reveals a susceptibility locus for high-density lipoprotein cholesterol on chromosome 16q

Pajukanta P, Allayee H, Krass KL, Kuraishy A, Soro A, Lilja HE, Mar R, Taskinen M-R, Nuotio I, Laakso M, Rotter JI, de Bruin TWA, Cantor RM, Lusis AJ, Peltonen L, Laakso M. AMERICAN JOURNAL OF HUMAN GENETICS 72: 903-917. 2003

Prolonged corrected QT interval is associated with acute and chronic hyperinsulinemia in nondiabetic subjects

Laitinen T, Vauhkonen I, Niskanen L, Hartikainen J, Uusitupa M, Laakso M. DIABETES CARE 26 8: 2480-2481. 2003

Impact of the pro12ala polymorphism of the PPAR-gamma2 gene on serum triacylglycerol response to n - 3 fatty acid supplementation. For the KANWU study group

Lindi V, Schwab U, Louheranta A, Laakso M, Vessby B, Hermansen K, Storlien L, Riccardi G, Rivellese AA, Uusitupa MIJ, for the KANWU Study Group, Laakso M. MOLECULAR GENETICS AND METABOLISM (ARLANDO) 79: 52-60. 2003

Progression of kidney disease varies between families with defects in the polycystic kidney disease type 1 gene in eastern Finland

Lumiaho A, Ikäheimo R, Pihlajamäki J, Miettinen R, Niemitukia L, Vanninen R, Lampainen E, Laakso M. SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY 37: 352-358. 2003

Insulin resistance is related to left ventricular hyperthrophy in patients with polycystic kidney disease type 1

Lumiaho A, Pihlajamäki J, Hartikainen J, Ikäheimo R, Miettinen R, Niemitukia L, Lampainen E, Laakso M. AMERICAN JOURNAL OF KIDNEY DISEASES 41 6: 1219-1224. 2003

Association of the PRO12ALA polymorphism of the PPAR-gamma2 gene with oxidized low-density lipoprotein and cardiolipin autoantibodies in nondiabetic and type 2 diabetic subjects

Niskanen L, Lindi V, Erkkilä A, Sivenius K, Luoma J, Ylä-Herttuala S, Laakso M, Uusitupa MIJ, Laakso M. METABOLISM: CLINICAL AND EXPERIMENTAL 52 2: 213-217. 2003

Reply (to the editor)

Niskanen L, Luoma J, Laakso M. METABOLISM: CLINICAL AND EXPERIMENTAL 52 12: 1648-1649. 2003

Diabetic nephropathy is associated with low-grade inflammation in Type 1 diabetic patients

Saraheimo M, Teppo A-M, Forsblom C, Fagerudd J, Groop P-H, on behalf of the FinnDiane Study Group, Laakso M, Voutilainen E, Niskanen L, Vauhkonen I, Ikäheimo R, Karhapää P, Mykkänen L. DIABETOLOGIA 46: 1402-1407. 2003

The Leu7Pro polymorphism of the neuropeptide Y gene regulates free fatty acid metabolism

Pihlajamäki J, Karhapää P, Vauhkonen I, Kekäläinen P, Kareinen A, Viitanen L, Pesonen U, Kallio J, Uusitupa M, Laakso M. METABOLISM: CLINICAL AND EXPERIMENTAL 52 5: 643-646. 2003

The effect of the -308A allele of the TNF-alfa gene on insulin action is dependent on obesity

Pihlajamäki J, Ylinen M, Karhapää P, Vauhkonen I, Laakso M. OBESITY (SILVER SPRING, MD.) 11 7: 912-917. 2003

Characterisation of new KATP-channel mutations associated with congenital hyperinsulinism in the Finnish population

Reimann F, Huopio H, Dabrowski M, Proks P, Gribble FM, Laakso M, Otonkoski T, Ashcroft FM, Laakso M. DIABETOLOGIA 46: 241-249. 2003

First-pass MR imaging in the assessment of perfusion impairment in patients with hypertrophic cardiomyopathy and the asp 175asn mutation of the alfa-tropomyosin gene

Sipola P, Lauerma K, Husso-Saastamoinen M, Kuikka JT, Vanninen E, Laitinen T, Manninen H, Niemi P, Peuhkurinen K, Jääskeläinen P, Laakso M, Kuusisto J, Aronen HJ, Laakso M. RADIOLOGY 226: 129-137. 2003

Cardiac adrenergic activity is associated with left ventricular hypertrophy in genetically homogenous subjects with hypertrophic cardiomyopathy

Sipola P, Vanninen E, Aronen HJ, Lauerma K, Simula S, Jääskeläinen P, Laakso M, Peuhkurinen K, Kuusisto J, Kuikka JT, Laakso M. JOURNAL OF NUCLEAR MEDICINE 44: 487-493. 2003

A deletion in the alfa2B-adrenergic receptor gene and autonomic nervous function in central obesity

Sivenius K, Niskanen L, Laakso M, Uusitupa M, Laakso M. OBESITY (SILVER SPRING, MD.) 11: 962-970. 2003

Dietary fat predicts coronary heart disease events in subjects with type 2 diabets

Soinio M, Laakso M, Lehto S, Hakala P, Rönnemaa T. DIABETES CARE 26: 619-624. 2003

Epidemiology and diagnosis of type 2 diabetes

Laakso M. Teoksessa: Goldstein BJ, Mûller-Wieland D (toim.), Textbook of Type 2 Diabetes.Martin Dunitz. ss. 1-12. 2003

Effects of euglycaemic and hypoglycaemic hyperinsulinaemia on sympathetic and parasympathetic regulation of haemodynamics in healthy subjects

Laitinen T, Huopio H, Vauhkonen I, Camaro C, Hartikainen J, Laakso M, Niskanen L. CLINICAL SCIENCE (LONDON) 105 3: 315-322. 2003

From hyperinsulinemia in childhood to diabetes in adulthood

Laakso M, Huopio H. Betteridge DJ, Case Studies in Diabetes.Martin Dunitz. 63-66. 2003

Akarboosi - tehokas lääke tyypin 2 diabeteksen ja sydänsairauksien estoon?

Laakso M. DUODECIM 119: 1921-1923. 2003

Effect of the pro12ala polymorphism in the peroxisome proliferator-activated receptor (PPAR) gamma2 gene on the expression of PPARgamma target genes in adipose tissue of massively obese subjects

Kolehmainen M, Uusitupa MIJ, Alhava E, Laakso M, Vidal H, Laakso M. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 88 4: 1717-1722. 2003

Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance: The STOPP-NIDDM Trial

Chiasson J-L, Josse RG, Gomis R, Hanefeld M, Karasik A, Laakso M, for the STOP-NIDDM Trial Research Group, Laakso M. JAMA - JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 290: 486-494. 2003

The effects of the Pro12Ala polymorphism of the PPARgamma-2 gene on lipid metabolism interact with body size at birth

Eriksson J, Lindi V, Uusitupa M, Forsén T, Laakso M, Osmond C, Barker D, Laakso M. CLINICAL GENETICS (COPENHAGEN) 64: 366-370. 2003

Interactions between peroxisome proliferator-activated receptor gene polymorphism and birth length influence risk for type 2 diabetes

Eriksson JG, Osmond C, Lindi V, Uusitupa M, Forsen T, Laakso M, Barker D, Laakso M. DIABETES CARE 26: 2476--2477. 2003

Understanding patient needs. Diabetology for cardiologists

Laakso M, Kuusisto J. EUROPEAN HEART JOURNAL. SUPPLEMENTS 5 (Suppl B): B5-B13. 2003

K121Q PC-1 gene polymorphism is not associated with insulin resistance in a Spanish population

González-Sánchez JL, Martínez-Larrad MT, Fernández-Pérez C, Kubaszek A, Laakso M, Serrano-Ríos M, Laakso M. OBESITY (SILVER SPRING, MD.) 11: 603-605. 2003

Safety and feasibility of catheter-based local intracoronary vascular endothelial growth factor gene transfer in the prevention of postangioplasty and in-stent restenosis and in the treatment of chronic myocardial ischemia: phase II [...]

Hedman M, Hartikainen J, Syvänne M, Stjernvall J, Hedman A, Kivelä A, Vanninen E, Mussalo H, Kauppila E, Simula S, Närvänen O, Rantala A, Peuhkurinen K, Nieminen MS, Laakso M, Ylä-Herttuala S. CIRCULATION 107: 2677-2683. 2003

A new subtype of autosomal dominant diabetes attributabe to a mutation in the gene for sulfonylurea receptor 1

Huopio H, Otonkoski T, Vauhkonen I, Reimann F, Ashcroft FM, Laakso M, Laakso M. LANCET 361: 301-07. 2003

Hexokinase II partial knockout impairs exercise-stimulated glucose uptake in oxidative muscles of mice

Fueger PT, Heikkinen S, Bracy DP, Malabanan CM, Pencek RR, Laakso M, Wasserman DH. AMERICAN JOURNAL OF PHYSIOLOGY. ENDOCRINOLOGY AND METABOLISM [PRINTED AND ONLINE: HTTP://AJPENDO.PHYSIOLOGY.ORG/] 285: E958-E963. 2003

Polymorphism in the peroxisome proliferator-activated receptor-gamma gene in women with polycystic ovary syndrome

Korhonen S, Heinonen S, Hiltunen M, Helisalmi S, Hippeläinen M, Koivunen R, Tapanainen JS, Laakso M, Laakso M. HUMAN REPRODUCTION 18 3: 540-543. 2003

The K121Q polymorphism of the PC-1 gene is associated with insulin resistance but not with dyslipidemia

Kubaszek A, Pihlajamäki J, Karhapää P, Vauhkonen I, Laakso M, Laakso M. DIABETES CARE 26: 464-467. 2003

Promoter polymorphisms of the TNF-alfa (G-308A) and IL-6 (C-174G) genes predict the conversion from impaired glucose tolerance to type 2 diabetes. The Finnish Diabetes Prevention Study

Kubaszek A, Pihlajamäki J, Komarovski V, Lindi V, Lindström J, Eriksson J, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Uusitupa M, Laakso M, Laakso M. DIABETES (NY) 52: 1872-1876. 2003

The C-174G promoter polymorphism of the IL-6 gene affects energy expenditure and insulin sensitivity

Kubaszek A, Pihlajamäki J, Punnonen K, Karhapää P, Vauhkonen I, Laakso M, Laakso M. DIABETES (NY) 52: 558-561. 2003

A novel mutation, Arg71Thr, in the delta-sarcoglycan gene is associated with dilated cardiomyopathy

Kärkkäinen S, Miettinen R, Tuomainen P, Kärkkäinen P, Heliö T, Reissell E, Kaartinen M, Toivonen L, Nieminen MS, Kuusisto J, Laakso M, Peuhkurinen K, Laakso M. JOURNAL OF MOLECULAR MEDICINE 81: 795-800. 2003

Candidate genes for insulin resistance: what's new?

Laakso M, Kubaszek A. Crepaldi G, Tiengo A, Avogaro A, The Metabolic Syndrome: Diabetes, Obesity, Hyperlipidemia and Hypertension. Proceedings of the 8th European Symposium on Metabolism.Elsevier. International Congress Series. 55-61. 2003

Coronary artery disease in type 2 diabetes

Laakso M, Kubaszek A. INTERNATIONAL DIABETES MONITOR 15 1: 1-7. 2003

Promoter polymorphisms -359T/C and -303A/G of the catalytic subunit p110beta gene of human phosphatidylinositol 3-kinase are not associated with insulin secretion or insulin sensitivity in Finnish subjects

Kossila M, Pihlajamäki J, Kärkkäinen P, Miettinen R, Kekäläinen P, Vauhkonen I, Ylä-Herttuala S, Laakso M, Laakso M. DIABETES CARE 26: 179-182. 2003

Lipids in type 2 diabetes

Laakso M. SEMINARS IN VASCULAR MEDICINE 2: 59-66. 2002

Polymorphism in the peroxisome proliferator-activated receptor-gamma gene in women with preeclampsia

Laasanen J, Heinonen S, Hiltunen M, Mannermaa A, Laakso M. EARLY HUMAN DEVELOPMENT 69: 77-82. 2002

Association between Chlamydia pneumoniae antibodies and intimal calcification in femoral arteries of nondiabetic patients

Lehto S, Niskanen L, Suhonen M, Rönnemaa T, Saikku P, Laakso M. ARCHIVES OF INTERNAL MEDICINE 162: 594-599. 2002

Association of the Pro12Ala polymorphism in the PPAR-gamma2 with 3-year incidence of type 2 diabetes and body weight change in the Finnish Diabetes Prevention Study

Lindi VI, Uusitupa MIJ, Lindström J, Louheranta A, Eriksson JG, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Laakso M, Tuomilehto J, for the Finnish Diabetes Prevention Study Group. DIABETES (NY) 51: 2581-2586. 2002

Cardiac adrenergic innervation is affected in asymptomatic subjects with very early stage of coronary artery disease

Simula S, Vanninen E, Viitanen L, Kareinen A, Lehto S, Pajunen P, Syvänne M, Kuikka J, Laakso M, Hartikainen J. JOURNAL OF NUCLEAR MEDICINE 43 1: 1-7. 2002

Baroreflex sensitivity in essential and secondary hypertension

Mussalo H, Vanninen E, Ikäheimo R, Laitinen T, Laakso M, Länsimies E, Hartikainen J. CLINICAL AUTONOMIC RESEARCH 12: 465-471. 2002

Serum homocysteine, creatinine, and glucose as predictors of the severity and extent of coronary artery disease in asymptomatic members of high-risk families

Pajunen P, Syvänne M, Nieminen MS, Kareinen A, Viitanen L, Lehto S, Laakso M. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION 32: 472-478. 2002

Interleukin 1 alpha gene polymorphism as a suscetibility factor in Alzheimer¿s disease and its influence on the extend of histopathological hallmark lesions of Alzheimer¿s sisease

Pirskanen M, Hiltunen M, Mannermaa A, Iivonen S, Helisalmi S, Lehtovirta M, Koivisto AM, Laakso M, Soininen H, Alafuzoff I. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS 14: 123-127. 2002

Genetic influences contributing to LDL particle siz in familial combined hyperlipidaemia

Vakkilainen J, Pajukanta P, Cantor RM, Nuotio IO, Lahdenperä S, Ylitalo K, Pihlajamäki J, Kovanen PT, Laakso M, Viikari JSA, Peltonen L, Taskinen M-R. EUROPEAN JOURNAL OF HUMAN GENETICS 10: 547-552. 2002

The heavy burden of cardiovascular disease in type 2 diabetes

Laakso M. Hâncu N, Cardiovascular Risk in Type 2 Diabetes Mellitus: Assessment and Control.Springer. 2-10. 2002

Effect of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor gamma-2 gene on adiposity, insulin sensitivity and lipid profile in the Spanish population

González Sánchez JL, Serrano Rios M, Fernandez Perez C, Laakso M, Martinez Larrad MT. EUROPEAN JOURNAL OF ENDOCRINOLOGY 147: 495-501. 2002

Diabetic macrovascular complications

Laakso M. Mogensen CA, Hypertension and Diabetes.Lippincott Williams & Wilkins. 69-79. 2002

Association of leucine 7 to proline 7 polymorphism in the preproneuropeptide Y with serum lipids in patients with coronary heart disease

Erkkilä AT, Lindi V, Lehto S, Laakso M, Uusitupa MIJ. MOLECULAR GENETICS AND METABOLISM (ARLANDO) 75: 260-264. 2002

No variants in the cardiac actin gene in Finnish patients with dilated or hypertrophic cardiomyopathy

Kärkkäinen S, Peuhkurinen K, Jääskeläinen P, Miettinen R, Kärkkäinen P, Kuusisto J, Laakso M. AMERICAN HEART JOURNAL 143: 11-14. 2002

Effects of losartan and captopril on mortality and morbidity in high-risk patients after acute myocardial infarction: the OPTIMAAL randomised trial

Dickstein K, Kjekshus J, and the OPTIMAAL Steering Committee, for the OPTIMAAL Study Group, Laakso M, Lehto S, Luoma J. LANCET 360: 752-760. 2002

The effects of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 gene on insulin sensitivity and insulin metabolism interact with size at birth

Eriksson JG, Lindi V, Uusitupa M, Forsén TJ, Laakso M, Osmond C, Barker DJP. DIABETES (NY) 51: 2321-2324. 2002

Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial

Chiasson J-L, Josse RG, Gomis R, Hanefeld M, Karasik A, Laakso M, for The STOP-NIDDM Trial Research Group. LANCET 359: 2072-2077. 2002

Variation in the fatty acid binding protein 2 gene is not associated with markers of metabolic syndrome in patients with coronary heart disease

Erkkilä AT, Lindi V, Lehto S, Pyörälä K, Laakso M, Uusitupa MIJ. NUTRITION, METABOLISM AND CARDIOVASCULAR DISEASES 12: 53-59. 2002

A meta-analytic investigation of linkage and association of common leptin receptor (LEPR) polymorphisms with body mass index an waist circumference

Heo M, Leibel RL, Fontaine KR, Boyer BB, Chung WK, Koulu M, Karvonen MK, Pesonen U, Rissanen A, Laakso M, Uusitupa MIJ, Chagnon Y, Bouchard C, Donohoue PA, Burns TL, Shuldiner AR, Silver K, Andersen RE, Pedersen O, Echwald S, Sorensen TIA, Behn P, Permutt MA, Jacobs KB, Elston RC, Hoffman DJ, Gropp E, Allison DB. INTERNATIONAL JOURNAL OF OBESITY 26: 640-646. 2002

Acute insulin response tests for the differential diagnosis of congenital hyperinsulinism

Huopio H, Jääskeläinen J, Komulainen J, Miettinen R, Kärkkäinen P, Laakso M, Tapanainen P, Voutilainen R, Otonkoski T. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 87: 4502-4507. 2002

Carriers of an inactivating beta-cell ATP-sensitive K+ channel mutation have normal glucose tolerance and insulin sensitivity and appropriate insulin secretion

Huopio H, Vauhkonen I, Komulainen J, Niskanen L, Otonkoski T, Laakso M. DIABETES CARE 25 1: 101-106. 2002

Mutations in the cardiac myosin-binding protein C gene are the predominant cause of familial hypertrophic cardiomyopathy in eastern Finland

Jääskeläinen P, Kuusisto J, Miettinen R, Kärkkäinen P, Kärkkäinen S, Heikkinen S, Peltola P, Pihlajamäki J, Vauhkonen I, Laakso M. JOURNAL OF MOLECULAR MEDICINE 80: 412-422. 2002

alpha-Synuclein pathology is highly dependent on the case selection

Parkkinen L, Soininen H, Laakso M, Alafuzoff I. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY 27 4: 314-325. 2001

Postprandial responses of individual fatty acids in subjects homozygous for the threonine- or alanine-encoding allele in codon 54 of the intestinal fatty acid binding protein 2 gene 1,2

Ågren JJ, Vidgren HM, Valve RS, Laakso M, Uusitupa MI. AMERICAN JOURNAL OF CLINICAL NUTRITION 73: 31-35. 2001

New amino acid substitutions in the IRS-2 gene in Finnish and Chinese subjects with late-onset type 2 diabetes

Wang H, Rissanen J, Miettinen R, Kärkkäinen P, Kekäläinen P, Kuusisto J, Mykkänen L, Karhapää P, Laakso M. DIABETES (NY) 50: 1949-1951. 2001

Apolipoprotein E gene promoter (-219G/T) polymorphism is associated with premature coronary heart disease

Viitanen L, Pihlajamäki J, Miettinen R, Kärkkäinen P, Vauhkonen I, Halonen P, Kareinen A, Lehto S, Laakso M. JOURNAL OF MOLECULAR MEDICINE 79: 732-737. 2001

Association of angiotensin converting enzyme and plasminogen activator inhibitor-1 promoter gene polymorphisms with features of the insulin resistance syndrome in patients with premature coronary heart disease

Viitanen L, Pihlajamäki J, Halonen P, Lehtonen M, Kareinen A, Lehto S, Laakso M. ATHEROSCLEROSIS 157: 57-64. 2001

APOE-epsilon4 is associated with weight loss in women with AD. A population-based study

Vanhanen M, Kivipelto M, Koivisto K, Kuusisto J, Mykkänen L, Helkala E-L, Hänninen T, Kervinen K, Kesäniemi YA, Laakso MP, Soininen H, Laakso M. NEUROLOGY 56: 655-659. 2001

Metabolic impact of a family history of type 2 diabetes. Results from a European multicentre study (EGIR)

Vaag A, Lehtovirta M, Thye-Rönn P, Groop L, for the European group of Insulin Resistance, Laakso M. DIABETIC MEDICINE 18: 533-540. 2001

Effect of a three-amino acid deletion in the alfa2B-adrenergic receptor gene on long-term body weight change in Finnish non-diabetic and type 2 diabetic subjects

Sivenius K, Lindi V, Niskanen L, Laakso M, Uusitupa M. INTERNATIONAL JOURNAL OF OBESITY 25: 1609-1614. 2001

An association between a subset of Finnish late-onset Alzheimer¿s disease and alpha2-macroglobulin

Pirskanen M, Alafuzoff I, Hiltunen M, Mannermaa A, Helisalmi S, Lehtovirta M, Koivisto AM, Laakso M, Soininen H. NEUROGENETICS 3: 171-172. 2001

The hormone sensitive lipase gene in familial combined hyperlipidemia and insulin resistance

Pihlajamäki J, Valve R, Karjalainen L, Karhapää P, Vauhkonen I, Laakso M. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION 31: 302-308. 2001

A major gene effect on fasting insulin and insulin sensitivity in familial combined hyperlipidemia

Pihlajamäki J, Austin M, Edwards K, Laakso M. DIABETES (NY) 50: 2396-2401. 2001

Heart rate variability and its determinants in patients with severe or mild essential hypertension

Mussalo H, Vanninen E, Ikäheimo R, Laitinen T, Laakso M, Länsimies E, Hartikainen J. CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING 5 21: 594-604. 2001

Insulin resistance syndrome predicts coronary heart disease events in elderly type 2 diabetic men

Kuusisto J, Lempiäinen P, Mykkänen L, Laakso M. DIABETES CARE 24: 1629-1633. 2001

Mitral valve prolapse and mitral regurgitation are common in patients with polycystic kidney disease type 1

Lumiaho A, Ikäheimo R, Miettinen R, Niemitukia L, Laitinen T, Rantala A, Lampainen E, Laakso M, Hartikainen J. AMERICAN JOURNAL OF KIDNEY DISEASES 38 6: 1208-1216. 2001

Effect of fenofibrate on progression of coronary-artery disease in type 2 diabetes: the Diabetes Atherosclerosis Intervention Study, a randomized study

Diabetes Atherosclerosis Intervention Study Investigators, Laakso M, Lehto S, Räisänen R, Jantunen A, Toivanen A. LANCET 357: 905-910. 2001

Comparison of baseline data, initial course, and management: Losartan versus Captopril following acute myocardial infarction (The OPTIMAAL Trial)

Dickstein K, Kjekshus J, for the OPTIMAAL Trial Steering Committee and Investigators, Laakso M. AMERICAN JOURNAL OF CARDIOLOGY 87: 766-771. 2001

APOE polymorphism and the hypertriglyceridemic effect of dietary sucrose 1-3

Erkkilä AT, Sarkkinen ES, Lindi V, Lehto S, Laakso M, Uusitupa MIJ. AMERICAN JOURNAL OF CLINICAL NUTRITION 73: 746-752. 2001

Cardiovascular risk factors associated with insulin resistence cluster in families with early-onset coronary heart disease

Kareinen A, Viitanen L, Halonen P, Lehto S, Laakso M. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 21: 1346-1352. 2001

Cardiovascular disease in type 2 diabetes: challenge for treatment and prevention

Laakso M. JOURNAL OF INTERNAL MEDICINE 249: 225-235. 2001

Diabetes and cardiovascular disease

Laakso M. Stalenhoef AFH, Kastelein JJP, Diabetes, Lipids and Cardiovascular Disease.Benecke N.I.. 111-125. 2001

Diabetic macroangiopathy

Laakso M. Pinchera A, Endocrinology and Metabolism.McGraw-Hill. 639-643. 2001

Insulin resistance and its impact on the approach to therapy of type 2 diabetes

Laakso M. INTERNATIONAL JOURNAL OF CLINICAL PRACTICE. SUPPLEMENT 121: 8-12. 2001

Effect of the Pro12Ala polymorphism of the PPAR-gamma2 gene on lon-term weight change in Finnish non-diabetic subjects

Lindi V, Sivenius K, Niskanen L, Laakso M, Uusitupa MIJ. DIABETOLOGIA 44: 925-926. 2001

Insulin resistance syndrome predicts the risk of coronary heart disease and stroke in healthy middle-aged men: the 22-year follow-up results of the Helsinki Policeman Study

Pyörälä M, Miettinen H, Halonen P, Laakso M, Pyörälä K. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 20: 538-544. 2000

Impaired free fatty acid suppression during hyperinsulinemia is a characteristic finding in familial combined hyperlipidemia, but insulin resistance is observed only in hypertriglyceridemic paitients

Pihlajamäki J, Karjalainen L, Karhapää P, Vauhkonen I, Laakso M. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 20: 164-170. 2000

G-250A substitution in promoter of hepatic lipase gene is associated with dyslipidemia and insulin resistance in healthy control subjects and in members of families with familial combined hyperlipidemia

Pihlajamäki J, Karjalainen L, Karhapää P, Vauhkonen I, Taskinen M-R, Deeb SS, Laakso M. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 20: 1789-95. 2000

The Pro12Ala substitution in the peroxisome proliferator activated receptor gamma 2 is associated with an insulin-sensitive phenotype in families with familial combined hyperlipidemia and in nondiabetic elderly subjects with d

Pihlajamäki J, Miettinen R, Valve R, Karjalainen L, Mykkänen L, Kuusisto J, Deeb S, Auwerx J, Laakso M. ATHEROSCLEROSIS 151: 567-574. 2000

Gly82Ser polymorphism of the receptor of advanced glycation end product gene is not associated with coronary heart disease in Finnish nondiabetic subjects or in patients with type 2 diabetes

Pulkkinen A, Viitanen L, Kareinen A, Lehto S, Laakso M. DIABETES CARE 23: 864. 2000

Mspl polymorphism at +83 bp in intron 1 of the human apolipoprotein A1 gene is associated with elevated levels of hdl cholesterol and apolipoprotein A1 in nondiabetic subjects but not in type 2 diabetic patients with coronary

Pulkkinen A, Viitanen L, Kareinen A, Lehto S, Laakso M. DIABETES CARE 23: 791-795. 2000

Hyperproinsulinemia is not a charascteristic feature in the offspring of patients with different phenotypes of type II diabetes

Vauhkonen IKJ, Niskanen LK, Mykkänen L, Haffner SM, Uusitupa MIJ, Laakso M. EUROPEAN JOURNAL OF ENDOCRINOLOGY 143: 251-260. 2000

Plasma insulin and all-cause, cardiovascular, and noncardiovascular mortality

Pyörälä M, Miettinen H, Laakso M, Pyörälä K. DIABETES CARE 23: 1097-1102. 2000

Sulfonylurea receptor 1 gene variants are associated with gestational diabetes and type 2 diabetes but not with altered secretion of insulin

Rissanen J, Markkanen A, Kärkkäinen P, Pihlajamäki J, Kekäläinen P, Mykkänen L, Kuusisto J, Karhapää P, Niskanen L, Laakso M. DIABETES CARE 23: 70-73. 2000

Variants in the hepatocyte nuclear factor-1alfa and -4alfa genes in Finnish and Chinese subjects with late-onset type 2 diabetes

Rissanen J, Wang H, Miettinen R, Kärkkäinen P, Kekäläinen P, Mykkänen L, Kuusisto J, Karhapää P, Niskanen L, Uusitupa M, Laakso M. DIABETES CARE 23: 1533-1538. 2000

Synergistic effect of polymorphisms in uncoupling protein 1 and beta3-adrenergic receptor genes on long-term body weight chance in Finnish type 2 diabetic and non-diabetic control subjects

Sivenius K, Valve R, Lindi V, Niskanen L, Laakso M, Uusitupa M. INTERNATIONAL JOURNAL OF OBESITY 24: 514-519. 2000

Impaired insulin secretion in non-diabetic offspring of probands with latent autoimmune diabetes mellitus in adults

Vauhkonen I, Niskanen L, Knip M, Ilonen J, Vanninen E, Kainulainen S, Uusitupa M, Laakso M. DIABETOLOGIA 43: 69-78. 2000

Leucine 7 to proline 7 polymorphism in the neuropeptide y gene is associated with retinopathy in Type 2 diabetes

Niskanen L, Voutilainen-Kaunisto R, Teräsvirta M, Karvonen M K, Valve R, Pesonen U, Laakso M, Uusitupa MIJ, Koulu M. EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY AND DIABETES 108: 235-236. 2000

Two loci on chromosomes 2 and X for premature coronary heart disease identified in early- and late-settlement populations of Finland

Pajukanta P, Cargill M, Viitanen L, Nuotio I, Kareinen A, Perola M, Terwilliger JD, Kempas E, Daly M, Lilja H, Rioux JD, Brettin T, Viikari JSA, Rönnemaa T, Laakso M, Lander ES, Peltonen L. AMERICAN JOURNAL OF HUMAN GENETICS 67: 1481-1493. 2000

Intron 4 polymorphism of the endothelial nitric oxide synthase gene is associated with elevated blood pressure in type 2 diabetic patients with coronary heart disease

Pulkkinen A, Viitanen L, Kareinen A, Lehto S, Vauhkonen I, Laakso M. JOURNAL OF MOLECULAR MEDICINE 78: 372-379. 2000

Leucine 7 to proline 7 polymorphism in the neuropeptide Y gene is associated with enhanced carotid atherosclerosis in elderly patients with type 2 diabetes and control subjects

Niskanen L, Karvonen MK, Valve R, Koulu M, Pesonen UM, Mercuri M, Rauramaa R, Töyry J, Laakso M, Uusitupa MIJ. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 85: 2266-2269. 2000

Cardiovascular disease and diabetes mellitus

Laakso M. EUROPEAN HEART JOURNAL. SUPPLEMENTS 2: D26-D28. 2000

Determinants of postabsorptive endogenous glucose output in non-diabetic subjects

Natali A, Toschi E, Camastra S, Gastaldelli A, Groop L, Ferrannini E, on behalf of the European Group for the Study of Insulin Resistance (EGIR), Laakso M. DIABETOLOGIA 43: 1266-1272. 2000

Dominantly inherited hyperinsulinism caused by a mutation in the sulfonylurea receptor type 1

Huopio H, Reimann F, Ashfield R, Komulainen J, Lenko H-L, Rahier J, Vauhkonen I, Kere J, Laakso M, Ashcroft F, Otonkoski T. JOURNAL OF CLINICAL INVESTIGATION 106: 897-906. 2000

Long-term association of cardiovascular risk factors with impaired insulin secretion and insulin resistance

Kekäläinen P, Sarlund H, Laakso M. METABOLISM: CLINICAL AND EXPERIMENTAL 49: 1247-1254. 2000

Apolipoprotein E phenotype alone does not influence survival in Alzheimer's disease: a population-based longitudinal study

Koivisto AM, Lempiäinen P, Koivisto K, Helkala E-L, Mykkänen L, Kuusisto J, Kervinen K, Kesäniemi YA, Laakso M, Soininen H. NEUROEPIDEMIOLOGY 19: 327-332. 2000

Aikuistyypin diabetes ja sydänsairaudet - ehkäisyn ja hoidon haasteet

Laakso M. ERIKOISLÄÄKÄRI 10: 131-139. 2000

Gene encoding the catalytic subunit p110beta of human phosphatidylinositol 3-kinase. Cloning, genomic structure, and screening for variants in patients with type 2 diabetes

Kossila M, Sinkovic M, Kärkkäinen P, Laukkanen MO, Miettinen R, Rissanen J, Kekäläinen P, Kuusisto J, Ylä-Herttuala S, Laakso M. DIABETES (NY) 49: 1740-1743. 2000

Hyperglycaemia as a cardiovascular risk factor

Laakso M. INTERNATIONAL DIABETES MONITOR 12: 1-5. 2000

Mouse hexokinase II gene: structure, cDNA, promoter analysis, and expression pattern

Heikkinen S, Suppola S, Malkki M, Deeb SS, Jänne J, Laakso M. MAMMALIAN GENOME (NEW YORK NY) 11: 91-96. 2000

Hyperglycemia and cardiovascular disease in patients with type 2 diabetes

Laakso M. CURRENT OPINION IN ENDOCRINOLOGY AND DIABETES 7: 197-202. 2000

Catheter-mediated vascular endothelial growth factor gene transfer to human coronary arteries after angioplasty

Laitinen M, Hartikainen J, Hiltunen MO, Eränen J, Kiviniemi M, Närvänen O, Mäkinen K, Manninen H, Syvänne M, Martin JF, Laakso M, Ylä-Herttuala S. HUMAN GENE THERAPY 11: 263-270. 2000

Depression after coronary heart disease events

Lehto S, Koukkunen H, Hintikka J, Viinamäki H, Laakso M, Pyörälä K. SCANDINAVIAN CARDIOVASCULAR JOURNAL (OSLO) 34: 580-583. 2000

Cardiovascular risk factors clustering with endogenous hyperinsulinaemia predict death from coronary heart disease in patients with type II diabetes

Lehto S, Rönnemaa T, Pyörälä K, Laakso M. DIABETOLOGIA 43: 148-155. 2000

Evidence for physiological coupling of insulin-mediated glucose metabolism and limb blood flow

Mather K, Laakso M, Edelman S, Hook G, Baron A. AMERICAN JOURNAL OF PHYSIOLOGY. ENDOCRINOLOGY AND METABOLISM [PRINTED AND ONLINE: HTTP://AJPENDO.PHYSIOLOGY.ORG/] 279: E1264-E1270. 2000

Reactive microglia in aging and dementia: an immunohistochemical study of postmortem human brain tissue

Overmyer M, Helisalmi S, Soininen H, Laakso M, Riekkinen P Sr, Alafuzoff I. ACTA NEUROPATHOLOGICA 97: 383-392. 1999

Short-term metabolic effects of isradipine and metoprolol in pre-eclampsia

Laivuori HM, Laakso M, Tikkanen MJ, Cacciatore B, Ylikorkala RO, Kaaja RJ. JOURNAL OF HYPERTENSION 17: 1189-1194. 1999

Poor glycemic control predicts coronary heart disease events in patients with type 1 diabetes without nephropathy

Lehto S, Rönnemaa T, Pyörälä K, Laakso M. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 19: 1014-1019. 1999

Insulin resistance syndrome predicts coronary heart disease events in elderly nondiabetic men

Lempiäinen P, Mykkänen L, Pyörälä K, Laakso M, Kuusisto J. CIRCULATION 100: 123-128. 1999

LDL size and risk of coronary heart disease in elderly men and women

Mykkänen L, Kuusisto J, Haffner SM, Laakso M, Austin MA. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 19: 2742-2748. 1999

Hyperglykemian lääkehoito ja aikuistyypin diabeteksen ennuste

Niskanen L, Uusitupa M, Laakso M. DUODECIM 115: 1122-1124. 1999

Astrogliosis and the ApoE genotype: an immunohistochemical study of postmortem human brain tissue

Overmyer M, Helisalmi S, Soininen H, Laakso M, Riekkinen P Sr, Alafuzoff I. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS 10: 252-257. 1999

Type-2 diabetes and cognitive function in a non-demented population

Vanhanen M, Kuusisto J, Koivisto K, Mykkänen L, Helkala E-L, Hänninen T, Riekkinen P Sr, Soininen H, Laakso M. ACTA NEUROLOGICA SCANDINAVICA 100: 97-101. 1999

Genomewide scan for familial combined hyperlipidemia genes in Finnish families, suggesting multiple susceptibility loci influencing triglyceride, cholesterol, and apolipoprotein B levels

Pajukanta P, Terwilliger JD, Perola M, Hiekkalinna T, Nuotio I, Ellonen P, Parkkonen M, Hartiala J, Ylitalo K, Pihlajamäki J, Porkka K, Laakso M, Viikari J, Ehnholm C, Taskinen M-R, Peltonen L. AMERICAN JOURNAL OF HUMAN GENETICS 64: 1453-1463. 1999

The codon 64 polymorphism of the beta3-adrenergic receptor gene is not associated with coronary heart disease or insulin resistance in nondiabetic subjects and non-insulin-dependent diabetic patients

Pulkkinen A, Kareinen A, Saarinen L, Heikkinen S, Lehto S, Laakso M. METABOLISM: CLINICAL AND EXPERIMENTAL 48: 853-856. 1999

Second European Stroke Prevention Study: antiplatelet therapy is effective regardless of age

Sivenius J, Cunha L, Diener H-C, Forbes C, Laakso M, Lowenthal A, Smets P, Riekkinen P Sr, for the ESPS2 Working Group. ACTA NEUROLOGICA SCANDINAVICA 99: 54-60. 1999

Antiplatelet treatment does not reduce the severity of subsequent stroke

Sivenius J, Cunha L, Diener H-C, Forbes C, Laakso M, Lowenthal A, Smets P, Riekkinen P Sr, for the European Stroke Prevention Study 2 Working Group. NEUROLOGY 53: 825-829. 1999

Baseline characteristics of the study population in the Diabetes Atherosclerosis Intervention Study (DAIS)

Steiner G, Stewart D, Hosking JD, And THE Dais Project Group And the World Health Organization Collaborating Centre For the Study of Atherosclerosis in Diabetes, Laakso M. AMERICAN JOURNAL OF CARDIOLOGY 84: 1004-1010. 1999

Simultaneous hypertrophic cardiomyopathy and ventricular septal defect in children

Tikanoja T, Jääskeläinen P, Laakso M, Kuusisto J. AMERICAN JOURNAL OF CARDIOLOGY 84: 485-486. 1999

Two polymorphisms in the peroxisome proliferator-activated receptor-gamma gene are associated with severe overweight among obese women

Valve R, Sivenius K, Miettinen R, Pihlajamäki J, Rissanen A, Deeb SS, Auwerx J, Uusitupa M, Laakso M. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 84 10: 3708-3712. 1999

Power spectral analysis of heart rate variability during hyperinsulinemia in nondiabetic offspring of type 2 diabetic patients: evidence for possible early autonomic dysfunction in insulin-resistant subjects

Laitinen T, Vauhkonen IKJ, Niskanen LK, Hartikainen JEK, Länsimies EA, Uusitupa MIJ, Laakso M. DIABETES (NY) 48: 1295-1299. 1999

Hyperglycemia as a risk factor for cardiovascular disease in type 2 diabetes

Laakso M. PRIMARY CARE; CLINICS IN OFFICE PRACTICE 26: 829-839. 1999

Hyperglycemia and cardiovascular disease in type 2 diabetes

Laakso M. DIABETES (NY) 48: 937-942. 1999

The cardiac troponin I gene is not associated with hypertrophic cardiomyopathy in patients from Eastern Finland

Jääskeläinen P, Miettinen R, Silvennoinen K, Vauhkonen I, Laakso M, Kuusisto J. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 31: 2031-2036. 1999

Hyperglycaemia as a risk factor for cardiovascular disease

Laakso M. Marshall SM, Home PD, Rizza RA, The Diabetes Annual/12.Elsevier. 317-328. 1999

Is leptin concentration associated with the insulin resistance syndrome in nondiabetic men?

Haffner SM, Mykkänen L, Rainwater DL, Karhapää P, Laakso M. OBESITY (SILVER SPRING, MD.) 7: 164-169. 1999

Hexokinase II-deficient mice: prenatal death of homozygotes without disturbances in glucose tolerance in heterozygotes

Heikkinen S, Pietilä M, Halmekytö M, Suppola S, Pirinen E, Deeb SS, Jänne J, Laakso M. JOURNAL OF BIOLOGICAL CHEMISTRY 274: 22517-22523. 1999

Identification of a three-amino acid deletion in the alfa2B-adrenergic receptor that is associated with reduced basal metabolic rate in obese subjects

Heinonen P, Koulu M, Pesonen U, Karvonen MK, Rissanen A, Laakso M, Valve R, Uusitupa M, Scheinin M. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 84: 2429-2433. 1999

Hyperinsulinemia predicts coronary heart disease risk in healthy middle-aged men

Hosszúfalusi N, Pánczél P, Jánoskuti L, Pyörälä M, Miettinen H, Laakso M, Pyörälä K. CIRCULATION [ONLINE: HTTP://CIRC.AHAJOURNALS.ORG/] 100 24: e118 [7.2.2000]. 1999

Independent influence of age on basal insulin secretion in nondiabetic humans

Iozzo P, Beck-Nielsen H, Laakso M, Smith U, Yki-Järvinen H, Ferrannini E, on behalf of the European Group for the Study of Insulin Resistance. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 84: 863-868. 1999

Effect of obesity and insulin resistance on resting and glucose-induced thermogenesis in man

Camastra S, Bonora E, Del Prato S, Rett K, Weck M, Ferrannini E, on behalf of EGIR (European Group for the Study of Insulin Resistance), Laakso M. INTERNATIONAL JOURNAL OF OBESITY 23: 1307-1313. 1999

Evidence of a state of increased insulin resistance in preeclampsia

Kaaja R, Laivuori H, Laakso M, Tikkanen MJ, Ylikorkala O. METABOLISM: CLINICAL AND EXPERIMENTAL 48: 892-896. 1999

Hyperinsulinemia cluster predicts the development of type 2 diabetes independently of family history of diabetes

Kekäläinen P, Sarlund H, Pyörälä K, Laakso M. DIABETES CARE 22: 86-92. 1999

Sarkomeerin geenimutaatiot - hypertrofisen kardiomyopatian syy

Kuusisto J, Jääskeläinen P, Laakso M. DUODECIM 115: 997-998. 1999

Insulin resistance syndrome and Alzheimer's disease: the summary of Finnish studies

Kuusisto J, Koivisto K, Mykkänen L, Helkala E, Vanhanen M, Hänninen T, Kervinen K, Kesäniemi YA, Riekkinen P, Laakso M. Vellas B, Fitten LJ, Research and Practice in Alzheimer's Disease.Serdi Publisher. 135-139. 1999

Prandial glucose regulation and cardiovascular disease in Type 2 diabetes

Kuusisto J, Laakso M. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. SUPPLEMENT 29: 7-11. 1999

Benefits of strict glucose and blood pressure control in type 2 diabetes: lessons from the UK Prospective Diabetes Study

Laakso M. CIRCULATION 99: 461-462. 1999

Reducing the burden of diabetes: managing cardiovascular disease

Keen H, Clark C, Laakso M. DIABETES, METABOLISM RESEARCH AND REVIEWS 15: 186-196. 1999

Linkage of familial combined hyperlipidaemia to chromosome 1q21-q23

Pajukanta P, Nuotio I, Terwilliger JD, Porkka KVK, Ylitalo K, Pihlajamäki J, Suomalainen AJ, Syvänen A-C, Lehtimäki T, Viikari JSA, Laakso M, Taskinen M-R, Ehnholm C, Peltonen L. NATURE GENETICS 18: 369-373. 1998

Risk factors and antiplatelet therapy in TIA and stroke patients

Puranen J, Laakso M, Riekkinen P Sr, Sivenius J. JOURNAL OF THE NEUROLOGICAL SCIENCES 154: 200-204. 1998

Efficacy of antiplatelet treatment in hypertensive patients with TIA or stroke

Puranen J, Laakso M, Riekkinen PJ Sr, Sivenius J. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY 32: 291-294. 1998

Hyperinsulinemia and the risk of stroke in healthy middle-aged men: 22-year follw-up results of the Helsinki Policemen Study

Pyörälä M, Miettinen H, Laakso M, Pyörälä K. STROKE 29: 1860-1866. 1998

Hyperinsulinemia predicts coronary heart disease risk in healthy middle-aged men: the 22-year follow-up results of the Helsinki Policemen Study

Pyörälä M, Miettinen H, Laakso M, Pyörälä K. CIRCULATION 98: 398-404. 1998

Glucokinase gene islet promoter region variant (G->A) at nucleotide -30 is not associated with reduced insulin secretion in Finns

Rissanen J, Saarinen L, Heikkinen S, Kekäläinen P, Mykkänen L, Kuusisto J, Deeb SS, Laakso M. DIABETES CARE 21: 1194-1197. 1998

Synergistic effect of polymorphisms in uncoupling protein 1 and beta3-adrenergic receptor genes on basal metabolic rate in obese Finns

Valve R, Heikkinen S, Rissanen A, Laakso M, Uusitupa M. DIABETOLOGIA 41: 357-361. 1998

Variants of the fatty acid-binding protein 2 gene are not associated with coronary heart disease in nondiabetic subjects and in patients with NIDDM

Saarinen L, Pulkkinen A, Kareinen A, Heikkinen S, Lehto S, Laakso M. DIABETES CARE 21: 849-850. 1998

Akuutin alkoholipankreatiitin jälkeiset glukoosiaineenvaihdunnan häiriöt

Saltevo J, Valtola K, Mecklin J-P, Palmu A, Niskanen L, Laakso M. DUODECIM 114: 1111-1115. 1998

Treatment of hypercholesterolemia and combined hyperlipidemia with simvastatin and gemfibrozil in patients with NIDDM: a multicenter comparison study

Tikkanen MJ, Laakso M, Ilmonen M, Helve E, Kaarsalo E, Kilkki E, Saltevo J, for the Study Group. DIABETES CARE 21 4: 477-481. 1998

Cognitive function in an elderly population with persistent impaired glucose tolerance

Vanhanen M, Koivisto K, Kuusisto J, Mykkänen L, Helkala E-L, Hänninen T, Riekkinen P Sr, Soininen H, Laakso M. DIABETES CARE 21 3: 398-402. 1998

Insulin resistant phenotype is associated with high serum leptin levels in offspring of patients with non-insulin-dependent diabetes mellitus

Vauhkonen I, Niskanen L, Haffner S, Kainulainen S, Uusitupa M, Laakso M. EUROPEAN JOURNAL OF ENDOCRINOLOGY 139: 598-604. 1998

Defects in insulin secretion and insulin action in non-insulin-dependent diabetes mellitus are inherited: metabolic studies on offspring of diabetic probands

Vauhkonen I, Niskanen L, Vanninen E, Kainulainen S, Uusitupa M, Laakso M. JOURNAL OF CLINICAL INVESTIGATION 101 1: 86-96. 1998

Postprandial lipemic response is modified by the polymorphism at codon 54 of the fatty acid-binding protein 2 gene

Ågren JJ, Valve R, Vidgren H, Laakso M, Uusitupa M. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 18: 1606-1610. 1998

Different regulation of free fatty acid levels and glucose oxidation by the Trp64Arg polymorphism of the beta3-adrenergic receptor gene and the promoter variant (A-3826G) of the uncoupling protein 1 gene in familial combined hyperlipidemia

Pihlajamäki J, Rissanen J, Valve R, Heikkinen S, Karjalainen L, Laakso M. METABOLISM: CLINICAL AND EXPERIMENTAL 47 11: 1397-1402. 1998

Identification of new sequence variants in the leptin gene

Karvonen MK, Pesonen U, Heinonen P, Laakso M, Rissanen A, Naukkarinen H, Valve R, Uusitupa MIJ, Koulu M. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 83 9: 3239-3242. 1998

Diabetes Atherosclerosis Intervention Study (DAIS): quantitative coronary angiographic analysis of coronary artery atherosclerosis

McLaughlin PR, Gladstone P, for the DAIS Project Group, Laakso M, Kettunen R, Eränen J. CATHETERIZATION AND CARDIOVASCULAR DIAGNOSIS 44: 249-256. 1998

The cardiac beta-myosin heavy chain gene is not the predominant gene for hypertrophic cardiomyopathy in the Finnish population

Jääskeläinen P, Soranta M, Miettinen R, Saarinen L, Pihlajamäki J, Silvennoinen K, Tikanoja T, Laakso M, Kuusisto J. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 32 6: 1709-1716. 1998

Functional consequences of naturally occurring variants of human hexokinase II

Malkki M, Laakso M, Deeb SS. DIABETOLOGIA 41: 1205-1209. 1998

The plate model: A visual method of teaching meal planning

Camelon KM, Hådell K, Jämsén PT, Ketonen KJ, Kohtamäki HM, Mäkimatilla S, Törmälä M-L, Valve RH, for the DAIS Project Group, Laakso M, Kettunen R, Eränen J, Lehto S. JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION 98 10: 1155-1158. 1998

A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity

Deeb SS, Fajas L, Nemoto M, Pihlajamäki J, Mykkänen L, Kuusisto J, Laakso M, Fujimoto W, Auwerx J. NATURE GENETICS 20: 284-287. 1998

Additive effects of the mutations in the beta3-adrenergic receptor and uncoupling protein-1 genes on weight loss and weight maintenance in Finnish women

Fogelholm M, Valve R, Kukkonen-Harjula K, Nenonen A, Hakkarainen V, Laakso M, Uusitupa M. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 83: 4246-4250. 1998

The authors reply to the editor (to Diabetes and coronary heart disease)

Haffner SM, Lehto S, Laakso M. NEW ENGLAND JOURNAL OF MEDICINE 339: 1716. 1998

Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction

Haffner SM, Lehto S, Rönnemaa T, Pyörälä K, Laakso M. NEW ENGLAND JOURNAL OF MEDICINE 339: 229-234. 1998

An international study on the efficacy of an alfa-glucosidase inhibitor to prevent type 2 diabetes in a population with impaired glucose tolerance: rationale, design, and preliminary screening data

Chiasson J-L, Gomis R, Hanefeld M, Josse RG, Karasik A, Laakso M, The STOPP-NIDDM Trial Research Group. DIABETES CARE 21: 1720-1725. 1998

Impaired insulin-stimulated glucose oxidation and free fatty acid suppression in patients with familial combined hyperlipidemia: a precursor defect for dyslipidemia?

Karjalainen L, Pihlajamäki J, Karhapää P, Laakso M. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 18: 1548-1553. 1998

Epidemiología de la enfermedad macrovascular en la diabetes

Laakso M, Lehto S. CARDIOLOGIA AL DIA 9: 202-223. 1998

Epidemiology of risk factors for cardiovascular disease in diabetes and impaired glucose tolerance

Laakso M, Lehto S. ATHEROSCLEROSIS. SUPPLEMENT 137: S65-S73. 1998

Hypertension and macrovascular disease - the killing fields of NIDDM

Laakso M. DIABETES RESEARCH AND CLINICAL PRACTICE. SUPPLEMENT 39: 27-33. 1998

Adenovirus-mediated gene transfer to lower limb artery of patients with chronic critical leg ischemia

Laitinen M, Mäkinen K, Manninen H, Matsi P, Kossila M, Agrawal RS, Pakkanen T, Luoma JS, Viita H, Hartikainen J, Alhava E, Laakso M, Ylä-Herttuala S. HUMAN GENE THERAPY 9: 1481-1486. 1998

Serum uric acid is a strong predictor of stroke in patients with non-insulin-dependent diabetes mellitus

Lehto S, Niskanen L, Rönnemaa T, Laakso M. STROKE 29: 635-639. 1998

Association of a leucine(7)-to-proline(7) polymorphism in the signal peptide of neuropeptide Y with high serum cholesterol and LDL cholesterol levels

Karvonen MK, Pesonen U, Koulu M, Niskanen L, Laakso M, Rissanen A, Dekker JM, ¿T Hart LM, Valve R, Uusitupa MIJ. NATURE MEDICINE 4 12: 1434-1437. 1998

The ala54thr polymorphism of the fatty acid binding protein 2 gene does not influence insulin sensitivity in Finnish nondiabetic and NIDDM subjects

Rissanen J, Pihlajamäki J, Heikkinen S, Kekäläinen P, Kuusisto J, Laakso M. DIABETES (NY) 46: 711-712. 1997

Relationship of LDL size to insulin sensitivity in normoglycemic men

Mykkänen L, Haffner SM, Rainwater DL, Karhapää P, Miettinen H, Laakso M. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 17: 1447-1453. 1997

Low insulin sensitivity is associated with clustering of cardiocascular risk factors

Mykkänen L, Haffner SM, Rönnemaa T, Bergman RN, Laakso M. AMERICAN JOURNAL OF EPIDEMIOLOGY 146: 315-321. 1997

Codon 54 polymorphism of the human intestinal fatty acid binding protein 2 gene is associated with dyslipidemias but not with insulin resistance in patients with familial combined hyperlipidemia

Pihlajamäki J, Rissanen J, Heikkinen S, Karjalainen L, Laakso M. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 17: 1039-1044. 1997

The trp64arg polymorphism of the beta3-adrenergic receptor gene

Rissanen J, Kuopusjärvi M, Pihlajamäki J, Sipiläinen R, Heikkinen S, Vanhala M, Kekäläinen P, Kuusisto J, Laakso M. DIABETES CARE 20 8: 1319-1323. 1997

Variants in the human intestinal fatty acid binding protein 2 gene in obese subjects

Sipiläinen R, Uusitupa M, Heikkinen S, Rissanen A, Laakso M. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 82: 2629-2632. 1997

New variants in the glycogen synthase gene (GIn71His, Met416Val) in patients with NIDDM from eastern Finland

Rissanen J, Pihlajamäki J, Heikkinen S, Kekäläinen P, Mykkänen L, Kuusisto J, Kolle A, Laakso M. DIABETOLOGIA 40: 1313-1319. 1997

Metabolic effects of diets rich in saturated and omega-6 polyunsatured fatty acids in healthy young females

Schwab US, Karhapää P, Sarkkinen ES, Salminen I, Laakso M, Uusitupa MIJ. DIABETES, NUTRITION & METABOLISM 10: 35-38. 1997

Polymorphism of the Beta3-adrenergic receptor gene affects basal metabolic rate in obese Finns

Sipiläinen R, Uusitupa M, Heikkinen S, Rissanen A, Laakso M. DIABETES (NY) 46: 77-80. 1997

Risk for non-insulin-dependent diabetes in the normoglycaemic elderly is associated with impaired cognitive function

Vanhanen M, Koivisto K, Karjalainen L, Helkala E-L, Laakso M, Soininen H, Riekkinen P Sr. NEUROREPORT 8 6: 1527-1530. 1997

Threonine allele in codon 54 of the fatty acid binding protein 2 gene does not modify the fatty acid composition of serum lipids in obese subjects

Vidgren HM, Sipiläinen RH, Heikkinen S, Laakso M, Uusitupa MIJ. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION 27: 405-408. 1997

Changes in autonomic nervous function during the 4-year follow-up in middle-aged diabetic and nondiabetic subjects initially free of coronary heart disease

Mustonen J, Uusitupa M, Mäntysaari M, Länsimies E, Pyörälä K, Laakso M. JOURNAL OF INTERNAL MEDICINE 241: 227-235. 1997

The relation of proinsulin, insulin and proinsulin-to-insulin ratio to insulin sensitivity and acute insulin response in normoglycemic subjects

Mykkänen L, Haffner SM, Hales CN, Rönnemaa T, Laakso M. DIABETES (NY) 46: 1990-1995. 1997

The human hexokinase II gene promoter: functional characterization and detection of variants among patients with NIDDM

Malkki M, Laakso M, Deeb SS. DIABETOLOGIA 40: 1461-1469. 1997

Insulin resistance and hypersecretion in obesity

Ferrannini E, Natali A, Bell P, Cavallo-Perin P, Lalic N, Mingrone G, on behalf of the European Group for the Study of Insulin Resistance (EGIR), Laakso M. JOURNAL OF CLINICAL INVESTIGATION 100: 1166-1173. 1997

VEGF gene transfer reduces intimal thickening via increased production of nitric oxide in carotid arteries

Laitinen M, Zachary I, Breier G, Pakkanen T, Häkkinen T, Luoma J, Abedi H, Risau W, Soma M, Laakso M, Martin JF, Ylä-Herttuala S. HUMAN GENE THERAPY 8: 1737-1744. 1997

Dyslipidemia, morbidity, and mortality in non-insulin-dependent diabetes mellitus: lipoproteins and coronary heart disease in non-insulin-dependent diabetes mellitus

Laakso M. JOURNAL OF DIABETES AND ITS COMPLICATIONS 11: 137-141. 1997

Epidemiology of macrovascular disease in diabetes

Laakso M, Lehto S. DIABETES REVIEWS 5: 294-315. 1997

Association between features of the insulin resistance syndrome and Alzheimer`s disease independently of apolipoprotein E4 phenotype:cross sectional population based study

Kuusisto J, Koivisto K, Mykkänen L, Helkala E-L, Vanhanen M, Hänninen T, Kervinen K, Kesäniemi YA, Riekkinen PJ, Laakso M. BMJ (COMPACT) 315: 1045-1049. 1997

Stability of age-associated memory impairment during a longitudinal population-based study

Helkala E-L, Koivisto K, Hanninen T, Vanhanen M, Kuusisto J, Mykkanen L, Laakso M, Riekkinen P Sr. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY 45 1: 120-122. 1997

Leptin concentrations and insulin sensitivity in normoglycemic men

Haffner SM, Miettinen H, Mykkänen L, Karhapää P, Rainwater DL, Laakso M. INTERNATIONAL JOURNAL OF OBESITY 21: 393-399. 1997

Leptin concentrations, sex hormones and cortisol in non-diabetic men

Haffner SM, Miettinen H, Karhapää P, Mykkänen L, Laakso M. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 82: 1807-1809. 1997

Insulin resistance, hyperinsulinemia, and blood pressure: role of age and obesity

Ferrannini E, Natali A, Capaldo B, Lehtovirta M, Jacob S, Yki-Järvinen H, for European Group for the Study of Insulin Resistance (EGIR), Laakso M. HYPERTENSION 30: 1144-1149. 1997

Akarboosi diabeteksen hoidossa

Eriksson J, Forsén B, Laakso M, Tuomilehto J. SUOMEN LÄÄKÄRILEHTI 52 4: 309-311. 1997

Insulin action and non-esterified fatty acids

Ferrannini E, Camastra S, Coppack SW, Fliser D, Golay A, Mitrakou A, on behalf of the European Group for the Study of Insulin Resistance (EGIR), Laakso M. PROCEEDINGS OF THE NUTRITION SOCIETY 56: 753-761. 1997

Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease

Farrer LA, Cupples LA, Haines JL, Hyman B, Kukull WA, Mayeux R, Myers RH, Pericak-Vance MA, Risch N, Van Duijn CM, for the APOE and Alzheimer Disease Meta Analysis Consorium, Koivisto K, Lehtovirta M, Riekkinen P Sr, Kuusisto J, Laakso M, Soininen H. JAMA - JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 278 16: 1349-1356. 1997

Dyslipidemia and hyperglycemia predict coronary heart disease events in middle-aged patients with NIDDM

Lehto S, Rönnemaa T, Haffner SM, Pyörälä K, Kallio V, Laakso M. DIABETES (NY) 46: 1354-1359. 1997

Predictors of stroke in middle-aged patients with non-insulin-dependent diabetes

Lehto S, Rönnemaa T, Pyörälä K, Laakso M. STROKE 27: 63-68. 1996

Risk factors predicting lower extremity amputations in patients with NIDDM

Lehto S, Rönnemaa T, Pyörälä K, Laakso M. DIABETES CARE 19: 607-612. 1996

Insulin resistance and coronary heart disease

Laakso M. CURRENT OPINION IN LIPIDOLOGY 7: 217-226. 1996

Medial artery calcification. A neglected harbinger of cardiovascular complications in non-insulin-dependent diabetes mellitus

Lehto S, Niskanen L, Suhonen M, Rönnemaa T, Laakso M. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 16: 978-983. 1996

Long-term influence of glycaemic control on cardiovascular risk in NIDDM

Laakso M. DIABETES RESEARCH AND CLINICAL PRACTICE. SUPPLEMENT 31: S61-S65. 1996

Association of Chlamydia pneumoniae and acute coronary heart disease events in non-insulin dependent diabetic and non-diabetic subjects in Finland

Miettinen H, Lehto S, Saikku P, Haffner SM, Rönnemaa T, Pyörälä K, Laakso M. EUROPEAN HEART JOURNAL 17: 682-688. 1996

Proteinuria predicts stroke and other atherosclerotic vascular disease events in non-insulin-dependent diabetic subjects

Miettinen H, Haffner SM, Lehto S, Rönnemaa T, Pyörälä K, Laakso M. STROKE 27: 2033-2039. 1996

The diabetes atherosclerosis intervention study (DAIS): a study conducted in cooperation with the World Health Organization

Steiner G for the DAIS Project Group, Laakso M, Kettunen R, Eränen J, Lehto S, Räisänen R. DIABETOLOGIA 39: 1655-1661. 1996

Retinopathy predicts coronary heart disease events in NIDDM patients

Miettinen H, Rönnemaa T, Haffner SM, Pyörälä K, Lehto S, Laakso M. DIABETES CARE 19 12: 1445-1448. 1996

Relationship of plasma insulin concentration and insulin sensitivity to blood pressure. Is it modified by obesity?

Mykkanen L, Haffner SM, Ronnemaa T, Watanable RW, Laakso M. JOURNAL OF HYPERTENSION 14: 399-405. 1996

The effects of weight loss on insulin sensitivity, skeletal muscle composition and capillary density in obese non-diabetic subjects

Niskanen L, Uusitupa M, Sarlund H, Siitonen O, Paljärvi L, Laakso M. INTERNATIONAL JOURNAL OF OBESITY 20: 154-160. 1996

Soluble interleukin-6 receptor as a prognostic factor in multiple myeloma

Pulkki K, Pelliniemi T-T, Rajamäki A, Tienhaara A, Laakso M, Lahtinen R. BRITISH JOURNAL OF HAEMATOLOGY 92: 370-374. 1996

Smoking is independently associated with high plasma insulin levels in nondiabetic men

Rönnemaa T, Pyörälä K, Rönnemaa EM, Laakso M, Puukka P. DIABETES CARE 19 11: 1229-1232. 1996

ERPs reveal deficits in automatic cerebral stimulus processing in patients with NIDDM

Vanhanen M, Karhu J, Koivisto K, Pääkkönen A, Partanen J, Laakso M, Riekkinen P Sr. NEUROREPORT 7 15-17: 2767-2771. 1996

Lipids and lipoproteins as risk factors for coronary heart disease in non-insulin-dependent diabetes mellitus

Laakso M. ANNALS OF MEDICINE (HELSINKI) 28: 341-345. 1996

Bisphosphonates in multiple myeloma: current status: future perspectives

Jantunen E, Laakso M. BRITISH JOURNAL OF HAEMATOLOGY 93: 501-506. 1996

Glycemic Control and the risk for coronary heart disease in patients with non-insulin-dependent diabetes mellitus: the Finnish studies

Laakso M. ANNALS OF INTERNAL MEDICINE 124 1: 127-130. 1996

Shift in the incidence of rheumatoid arthritis towards wlderly patients in Finland during 1975-1990

Kaipiainen-Seppänen O, Aho K, Isomäki H, Laakso M. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY 14: 537-542. 1996

Glycaemic control and macrovascular disease in NIDDM

Laakso M. DIAMET: DIABETES METABOLISM 44: 1-3. 1996

Monitoring the action of clodronate with type I collagen metabolites in multiple myeloma

Elomaa I, Risteli L, Laakso M, Lahtinen R, Virkkunen P, Risteli J. EUROPEAN JOURNAL OF CANCER 32A: 1166-1170. 1996

Insulin action and age

Ferrannini E, Vichi S, Beck-Nielsen H, Laakso M, Paolisso G, Smith U, European Group for the Study of Insulin Resistance (EGIR). DIABETES (NY) 45: 947-953. 1996

Memory functions in human subjects with different apolipoprotein E phenotypes during a 3-year population-based follow-up study

Helkala E-L, Koivisto K, Hänninen T, Vanhanen M, Kervinen K, Kuusisto J, Mykkänen L, Kesäniemi YA, Laakso M, Riekkinen P Sr. NEUROSCIENCE LETTERS 204: 177-180. 1996

Prevalence of ageing-associated cognitive decline in an elderly population

Hänninen T, Koivisto K, Reinikainen KJ, Helkala E-L, Soininen H, Mykkänen L, Laakso M, Riekkinen PJ. AGE AND AGEING 25: 201-205. 1996

Incidence of rheumatoid arthritis in Finland during 1980-1990

Kaipiainen-Seppänen O, Aho K, Isomäki H, Laakso M. ANNALS OF THE RHEUMATIC DISEASES 55: 608-611. 1996

Ryhmät

Metabolite Signature of Physical Activity and the Risk of Type 2 Diabetes in 7271 Men

Large-scale association analyses identify host factors influencing human gut microbiome composition

Machine Learning Reveals Time-Varying Microbial Predictors with Complex Effects on Glucose Regulation

Elevated circulating follistatin associates with an increased risk of type 2 diabetes

Profiles of glucose metabolism in different prediabetes phenotypes, classified by fasting glycemia, 2-hour OGTT, glycated hemoglobin, and 1-hour OGTT: An IMI DIRECT study

Effect of lifestyle intervention on the risk of incident diabetes in individuals with impaired fasting glucose and low or high genetic risk for the development of type 2 diabetes in men: a T2D-GENE trial

Insulin Resistance Is Associated With Enhanced Brain Glucose Uptake During Euglycemic Hyperinsulinemia: A Large-Scale PET Cohort

n-3 Fatty Acid Biomarkers and Incident Type 2 Diabetes: An Individual Participant-Level Pooling Project of 20 Prospective Cohort Studies

Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes

Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability

FADS1 rs174550 genotype and high linoleic acid diet modify plasma PUFA phospholipids in a dietary intervention study

Model-based assessment of replicability for genome-wide association meta-analysis

Molecular epidemiology of hereditary ataxia in Finland

The FADS1 Genotype Modifes Metabolic Responses to the Linoleic Acid and Alpha-linolenic Acid Containing Plant Oils-Genotype Based Randomized Trial FADSDIET2

Chromatin accessibility and gene expression during adipocyte differentiation identify context-dependent effects at cardiometabolic GWAS loci

Sex-specific genetic regulation of adipose mitochondria and metabolic syndrome by Ndufv2

The power of genetic diversity in genome-wide association studies of lipids

Glycogen metabolism links glucose homeostasis to thermogenesis in adipocytes

The trans-ancestral genomic architecture of glycemic traits

Association of structural variation with cardiometabolic traits in Finns

The "Common Soil Hypothesis" Revisited - Risk Factors for Type 2 Diabetes and Cardiovascular Disease

Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes

Mitochondrial genome copy number measured by DNA sequencing in human blood is strongly associated with metabolic traits via cell-type composition differences

Addendum: The mutational constraint spectrum quantified from variation in 141,456 humans

SUR1-E1506K mutation impairs glucose tolerance and promotes vulnerable atherosclerotic plaque phenotype in hypercholesterolemic mice

Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies

Rare coding variants in 35 genes associate with circulating lipid levels - A multi-ancestry analysis of 170,000 exomes

The association of nine amino acids with cardiovascular events in Finnish men in a 12-year follow-up study

Evaluating drug targets through human loss-of-function genetic variation

Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

Simvastatin profoundly impairs energy metabolism in primary human muscle cells

Clinical and Genetic Characterization of 153 Patients with Persistent or Transient Congenital Hyperinsulinism

Clinical profiles of post-load glucose subgroups and their association with glycaemic traits over time: an IMI-DIRECT study

Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes: An IMI-DIRECT study

Generation of a human induced pluripotent stem cell line (UEFi003-A) carrying heterozygous A673T variant in amyloid precursor protein associated with a reduced risk of Alzheimer's disease

Estrogen receptor α controls metabolism in white and brown adipocytes by regulating Polg1 and mitochondrial remodeling

Cardiomyopathy associated with the Ala143Thr variant of the α-galactosidase A gene

Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus

Microbiota-Related Metabolites and the Risk of Type 2 Diabetes

Landscape of multi-nucleotide variants in 125,748 human exomes and 15,708 genomes

The effect of LRRK2 loss-of-function variants in humans

Characterising the loss-of-function impact of 5' untranslated region variants in 15,708 individuals

Efficient Estimation and Applications of Cross-Validated Genetic Predictions to Polygenic Risk Scores and Linear Mixed Models

The causal effect of obesity on prediabetes and insulin resistance reveals the important role of adipose tissue in insulin resistance

Adiponectin GWAS loci harboring extensive allelic heterogeneity exhibit distinct molecular consequences

Ryhmissä toteutettavalla elämäntapaohjauksella on merkittäviä tuloksia terveyteen

Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study

Voidaanko elintavoilla ehkäistä tyypin 2 diabtesta myös korkean geneettisen riskin omaavilla henkilöillä?

Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts

A reference map of potential determinants for the human serum metabolome.

A structural variation reference for medical and population genetics

Transcript expression-aware annotation improves rare variant interpretation

Genome-Wide Association Analysis of Pancreatic Beta Cell Glucose Sensitivity

Metabolite signature of albuminuria involves amino acid pathways in 8,661 Finnish men without diabetes

Fgr kinase is required for proinflammatory macrophage activation during diet-induced obesity

Mapping and characterization of structural variation in 17,795 human genomes

Novel biomarkers associated with incident heart failure in 10 106 Finnish men

Association Analysis and Meta-Analysis of Multi-Allelic Variants for Large-Scale Sequence Data

The mutational constraint spectrum quantified from variation in 141,456 humans

RIPK1 gene variants associate with obesity in humans and can be therapeutically silenced to reduce obesity in mice

The Role of Physical Activity in Metabolic Homeostasis Before and After the Onset of Type 2 Diabetes: An IMI DIRECT Study

Gamma-glutamyltransferase, arterial remodeling and prehypertension in a healthy population at low cardiometabolic risk

Fatty acids in the de novo lipogenesis pathway and incidence of type 2 diabetes: A pooled analysis of prospective cohort studies

Biomarkers of Dietary Omega-6 Fatty Acids and Incident Cardiovascular Disease and Mortality: An Individual-Level Pooled Analysis of 30 Cohort Studies

Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium

Biomarkers for type 2 diabetes

Inflammatory response to dietary linoleic acid depends on FADS1 genotype

Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

Exome sequencing of Finnish isolates enhances rare-variant association power

Integrative analysis of gene expression, DNA methylation, physiological traits, and genetic variation in human skeletal muscle

Adipose Tissue Gene Expression Associations Reveal Hundreds of Candidate Genes for Cardiometabolic Traits

Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology

A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure

Nine Amino Acids are Associated with Decreased Insulin Secretion and Elevated Glucose Levels in a 4.6-Year Follow-Up Study of 5,181 Finnish Men

Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration

Colocalization of GWAS and eQTL signals at loci with multiple signals identifies additional candidate genes for body fat distribution

A catalog of genetic loci associated with kidney function from analyses of a million individuals

Disentangling the genetics of lean mass