MARKUS FORSBERG

Yhteystiedot

TUTKIMUSRYHMÄT - UEF

• 
  Hermoston farmakologia ja lääkekohteet tutkimuskonsortio

Julkaisut

• Grotell, Milo; den Hollander, Bjørnar; Jalkanen, Aaro; Törrönen, Essi; Ihalainen, Jouni; de Miguel, Elena; Dudek, Mateusz; Kettunen, Mikko I; Hyytiä, Petri; Forsberg, Markus M; Kankuri, Esko; Korpi, Esa R. 2021. Alcohol Co-Administration Changes Mephedrone-Induced Alterations of Neuronal Activity Frontiers in pharmacology 12: 679579. 2021
• Jalkanen, Aaro J.; Ihalainen, Jouni; Lehtonen, Marko; Forsberg, Markus M.; Rautio, Jarkko; Huttunen, Kristiina M.; Gynther, Mikko. 2021. Species differences in the intra-brain distribution of an L-type amino acid transporter 1 (LAT1) -utilizing compound between mice and rats International journal of pharmaceutics 596: 120300. 2021
• Savolainen, Katja; Ihalainen, Jouni; Hämäläinen, Elina; Tanila, Heikki; Forsberg, Markus M. 2021. Phencyclidine-induced cognitive impairments in repeated touchscreen visual reversal learning tests in rats Behavioural brain research 404: 113057. 2021
• Zhurakovskaya, Ekaterina; Leikas, Juuso; Pirttimäki, Tiina; Casas Mon, Francesc; Gynther, Mikko; Aliev, Rubin; Rantamäki, Tomi; Tanila, Heikki; Forsberg, Markus M; Gröhn, Olli; Paasonen, Jaakko; Jalkanen, Aaro J. 2019. Sleep-State Dependent Alterations in Brain Functional Connectivity under Urethane Anesthesia in a Rat Model of Early-Stage Parkinson's Disease eNeuro 6 1: 1-12. 2019
• Aivolisäkkeen ja hypotalamuksen hormonit. Raasmaja, Atso; Forsberg, Markus / Farmakologia ja toksikologia. 2018. 2018
• Antiseptit ja desinfektioaineet. Forsberg, Markus; Raasmaja, Atso / Farmakologia ja toksikologia. 2018. 2018
• Kilpirauhashormonit ja tyreostaatit. Forsberg, Markus; Raasmaja, Atso / Farmakologia ja toksikologia. 2018. 2018
• Lukin, Alexey; Kramer, Jan; Hartmann, Markus; Weizel, Lilia; Hernandez- Olmos, Victor; Falahati, Konstantin; Burghardt, Irene; Kalinchenkova, Natalia; Bagnyukova, Darya; Zhurilo, Nikolay; Rautio, Jarkko; Forsberg, Markus; Ihalainen, Jouni; Auriola, Seppo; Leppänen, Jukka; Konstantinov, Igor; Pogoryelov, Denys; Proschak, Ewgenij; Dar'in, Dmitry; Krasavin, Mikhail. 2018. Discovery of Polar Spirocyclic Orally Bioavailable Urea Inhibitors of Soluble Epoxide Hydrolase Bioorganic chemistry 80: 655-667. 2018
• Savolainen, Katja; Ihalainen, Jouni; Jalkanen, Aaaro J; Forsberg, Markus M. 2018. Selective adrenergic alpha2C receptor antagonist ameliorates acute phencyclidine-induced schizophrenia-like social interaction deficits in rats Psychopharmacology 2019; 236 4: 1245-1253. 2018
• Airaksinen Marja, Forsberg Markus, Katajavuori Nina, Palmgrèn Joni, Puumalainen Inka, Ritala-Nurmi Anneli, Suhonen Pekka. 2017. Suomi 100 - Dosis 33!. DOSIS : FARMASEUTTINEN AIKAKAUSKIRJA 33 4: 227-228. 2017
• Leikas J V, Kohtala S, Theilmann W, Jalkanen A J, Forsberg M M, Rantamäki T. 2017. Brief isoflurane anesthesia regulates striatal AKT-GSK3ß signaling and ameliorates motor deficits in a rat model of early-stage Parkinson's disease. JOURNAL OF NEUROCHEMISTRY 142 3: 456-463. 2017
• Leikas JV, Kääriäinen TM, Jalkanen AJ, Lehtonen M, Rantamäki T, Forsberg MM. 2017. Combined ipsilateral limb use score as an index of motor deficits and neurorestoration in parkinsonian rats. JOURNAL OF NEUROSCIENCE RESEARCH 95 9: 1858-1870. 2017
• Paasonen J, Salo RA, Ihalainen J, Leikas JV, Savolainen K, Lehtonen M, Forsberg MM, Gröhn O. 2017. Dose-response effect of acute phencyclidine on functional connectivity and dopamine levels, and their association with schizophrenia-like symptom classes in rat. NEUROPHARMACOLOGY 119: 15-25. 2017
• Vellonen KS, Ihalainen J, Boucau M-C, Gosselet F, Picardat T, Gynther M, Kanninen KM, White AR, Malm T, Koistinaho J, Forsberg MM, Ruponen M. 2017. Disease-Induced Alterations in Brain Drug Transporters in Animal Models of Alzheimer's Disease. PHARMACEUTICAL RESEARCH 34 12: 2652-2662. 2017
• Paasonen Jaakko, Salo Raimo A, Shatillo Artem, Forsberg Markus M, Närväinen Johanna, Huttunen Joanna K, Gröhn Olli. 2016. Comparison of seven different anesthesia protocols for nicotine pharmacologic magnetic resonance imaging in rat. EUROPEAN NEUROPSYCHOPHARMACOLOGY 26 3: 518-531. 2016
• Krasavin Mikhail, Lukin Alexey, Bagnyukova Daria, Zhurilo Nikolay, Zahanich Ihor, Zozulya Sergey, Ihalainen Jouni, Forsberg Markus M, Lehtonen Marko, Rautio Jarkko, Moore Daniel, Tikhonova Irina G. 2016. Free fatty acid receptor 1 (GPR40) agonists containing spirocyclic periphery inspired by LY2881835. BIOORGANIC AND MEDICINAL CHEMISTRY 24 21: 5481-5494. 2016
• Ihalainen Jouni, Savolainen Katja, Tanila Heikki, Forsberg Markus M. 2016. Comparison of phencyclidine-induced spatial learning and memory deficits and reversal by sertindole and risperidone between Lister Hooded and Wistar rats. BEHAVIOURAL BRAIN RESEARCH 305: 140-147. 2016
• Küblbeck Jenni, Hakkarainen Jenni J, Petsalo Aleksanteri, Vellonen Kati-Sisko, Tolonen Ari, Reponen Petri, Forsberg Markus M, Honkakoski Paavo. 2016. Genetically Modified Caco-2 Cells With Improved Cytochrome P450 Metabolic Capacity. JOURNAL OF PHARMACEUTICAL SCIENCES 105 2: 941-949. 2016
• Forsberg Markus, Ritala-Nurmi Anneli. 2015. Kasvit lääkkeinä ja uusien lääkeaineiden lähteinä. DOSIS : FARMASEUTTINEN AIKAKAUSKIRJA 31 3: 3. 2015
• Airaksinen Marja, Puumalainen Inka, Forsberg Markus, Ritala-Nurmi Anneli, Katajavuori Nina, Suhonen Pekka, Palmgren Joni. 2014. 30 vuosikertaa Dosista [Pääkirjoitus]. DOSIS : FARMASEUTTINEN AIKAKAUSKIRJA 30 1: 3-4. 2014
• Forsberg Markus, Ihalainen Jouni, Savolainen Katja, Jalkanen Aaro. 2014. Skitsofrenian sosiaalisten ja kognitiivisten oireiden uudet mallit ja hoitokonseptit. DOSIS : FARMASEUTTINEN AIKAKAUSKIRJA 30 3: 192. 2014
• Gynther Mikko, Kääriäinen Tiina M, Hakkarainen Jenni J, Jalkanen Aaro J, Petsalo Aleksanteri, Lehtonen Marko, Peura Lauri, Kurkipuro Jere, Samaranayake Haritha, Yla-Herttuala Seppo, Rautio Jarkko, Forsberg Markus M. 2014. Brain Pharmacokinetics of Ganciclovir in Rats with Orthotopic BT4C Glioma. DRUG METABOLISM AND DISPOSITION 2015; 43: 140-146. 2014
• Jalkanen Aaro J, Leikas Juuso V, Forsberg Markus M. 2014. Prolyl oligopeptidase inhibition decreases extracellular acetylcholine levels in rat hippocampus and prefrontal cortex. NEUROSCIENCE LETTERS 579: 110-113. 2014
• Hakkarainen Jenni J, Rilla Kirsi, Suhonen Marjukka, Ruponen Marika, Forsberg Markus M. 2013. Re-evaluation of the role of P-glycoprotein in in vitro drug permeability studies with the bovine brain microvessel endothelial cells. XENOBIOTICA (LONDON) 2014:44: 283-294. 2013
• Jalkanen Aaro J, Leikas Juuso V, Forsberg Markus M. 2013. KYP-2047 penetrates mouse brain and effectively inhibits mouse prolyl oligopeptidase. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY 2014:114: 460-463. 2013
• Peura Lauri, Malmioja Kalle, Huttunen Kristiina, Leppänen Jukka, Hämäläinen Miia, Forsberg Markus M, Gynther Mikko, Rautio Jarkko, Laine Krista. 2013. Design, synthesis and brain uptake of LAT1-targeted amino acid prodrugs of dopamine. PHARMACEUTICAL RESEARCH 30: 2523-2537. 2013
• Raunio Hannu, Forsberg Markus, Vähäkangas Kirsi. 2013. Farmakologia 2003-2013 - tulijoita ja menijöitä: Ahonen R, Laitinen K, Lapinjoki S, Mensalo P, Ranta V-P, Ylikangas H (toim)., Muutosten vuosikymmen : Itä-Suomen yliopiston farmasian laitos 40 vuotta. Publications of the University of Eastern Finland. General Series 13. 31-34. 2013
• Hakkarainen Jenni J, Rilla Kirsi, Ruponen Marika, Suhonen Marjukka, Forberg Markus M. 2012. The Role of P-Glycoprotein Mediated Efflux in the Drug Transport through the Bovine Brain Microvessel Endothelial cells in Vitro. Teoksessa: (toim.), FinPharma Doctoral Program (FPDP): 6th Joint Meeting at the University of Turku, August 16-17, 2012, Turku, Finland. ss. 28:323. 2012
• Kääriäinen Tiina M, Käenmäki Mikko, Forsberg Markus M, Oinas Niko, Tammimäki Anne, Männistö Pekka T. 2012. Unpredictable rotational responses to L-dopa in the rat model of Parkinson's disease: the role of L-dopa pharmacokinetics and striatal dopamine depletion BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY 110: 162-170. 2012
• Jalkanen Aaro J, Piepponen T. Petteri, Hakkarainen Jenni J, De Meester Ingrid, Lambeir Anne-Marie, Forsberg Markus M. 2012. The effect of prolyl oligopeptidase inhibition on extracellular acetylcholine and dopamine levels in the rat striatum NEUROCHEMISTRY INTERNATIONAL 60: 301-309. 2012
• Hakkarainen Jenni J, Pajander Jari, Laitinen Riikka, Suhonen Marjukka, Forsberg Markus M. 2012. Similar molecular descriptors determine the in vitro drug permeability in endothelial and epithelial cells INTERNATIONAL JOURNAL OF PHARMACEUTICS 436 1-2: 426-443. 2012
• Forsberg Markus, Suhonen Pekka. 2012. Uusi ajattelu- ja toimintatapa lääketutkimuksessa ja -kehityksessä [Pääkirjoitus]. DOSIS : FARMASEUTTINEN AIKAKAUSKIRJA 28 1: 6. 2012
• Airaksinen Marja, Forsberg Markus, Katajavuori Nina, Oksman-Caldentey Kirsi-Marja, Puumalainen Inka, Saastamoinen Leena, Suhonen Pekka. 2012. Theme: Current developments in pharmaceutical policy and services in Finland [Editorial]. DOSIS : FARMASEUTTINEN AIKAKAUSKIRJA 28 3: 184. 2012
• Airaksinen Marja, Forsberg Markus, Katajavuori Nina, Oksman-Caldentey Kirsi-Marja, Puumalainen Inka, Saastamoinen Leena, Suhonen Pekka. 2012. Teemanumero: Ajankohtaiskatsaus lääkepolitiikkaan ja lääkehuoltopalveluihin Suomessa [Editorial]. DOSIS : FARMASEUTTINEN AIKAKAUSKIRJA 28 3: 185. 2012
• Jalkanen Aaro J, Hakkarainen Jenni J, Lehtonen Marko, Venäläinen Tetta, Kääriäinen Tiina M, Jarho Elina, Suhonen Marjukka, Forsberg Markus M. 2011. Brain pharmacokinetics of two prolyl oligopeptidase inhibitors, JTP-4819 and KYP-2047, in the rat BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY 109: 443-451. 2011
• Jalkanen Aaro J, Savolainen Katja, Forsberg Markus M. 2011. Inhibition of prolyl oligopeptidase by KYP-2047 fails to increase the extracellular neurotensin and substance P levels in rat striatum NEUROSCIENCE LETTERS 502: 107-111. 2011
• Moreno-Baylach José, Puttonen Katja, Tenorio-Laranga Jofre, Venäläinen Jarkko, Storvik Markus, Forsberg Markus, García-Horsman Arturo. 2011. Prolyl endopeptidase is involved in cellular signalling in human neuroblastoma SH-SY5Y cells Neurosignals 19: 97 - 109. 2011
• Lampela P, Forsberg M, Bell JS & Hartikainen S. 2010. Antikolinergisen vaikutuksen arviointi vanhusten lääkityksessä on vaikeaa. (Näkökulma-palsta). SUOMEN LÄÄKÄRILEHTI 65 40: 3202-3203. 2010
• Hakkarainen JJ, Jalkanen AJ, Kääriäinen TM, Keski-Rahkonen P, Venäläinen T, Hokkanen J, Mönkkönen J, Suhonen M & Forsberg MM. 2010. Comparison of in vitro cell models in predicting in vivo brain entry of drugs. INTERNATIONAL JOURNAL OF PHARMACEUTICS 402: 27-36. 2010
• Gynther M, Jalkanen A, Lehtonen M, Forsberg M, Laine K, Ropponen J, Leppänen J, Knuuti J & Rautio J. 2010. Brain uptake of ketoprofen-lysine prodrug in rats. INTERNATIONAL JOURNAL OF PHARMACEUTICS 399: 121-128. 2010
• Tamminmäki A, Forsberg MM, Karayiorgou M, Gogos JA, Männistö PT. 2008. Increase in free choice oral ethanol self-administration in Catechol-O-methyltransferase gene-disrupted male mice. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY 103: 297-304. 2008
• Jarho EM, Venäläinen JI, Poutiainen S, Leskinen H, Vepsäläinen J, Christiaans JAM, Forsberg MM, Männistö PT, Wallén EAA. 2007. 2(S)-(cycloalk-1-enecarbonyl)-1-(4-phenyl-butanoyl)pyrrolidines and 2(S)-(aroyl)-1-(4-phenylbutanoyl)pyrrolidines as prolyl oligopeptidase inhibitors. BIOORGANIC AND MEDICINAL CHEMISTRY 15: 2024-2031. 2007
• Kääriäinen TM, Lehtonen M, Forsberg MM, Savolainen J, Käenmäki M, Männistö PT. 2007. Comparison of the effects of deramciclane, ritanserin and buspirone on extracellular dopamine and its metabolites in striatum and nucleus accumbens of freely moving rats BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY 102: 50-58. 2007
• Yavich L, Forsberg MM, Karayiorgou M, Gogos JA, Männistö PT. 2007. Site-specific role of catechol-O-methyltransferase in dopamine overflow within prefrontal cortex and dorsal striatum. JOURNAL OF NEUROSCIENCE 27 38: 10196-10202. 2007
• Jarho EM, Venäläinen J, Juntunen J, Yli-Kokko AL, Vepsäläinen J, Christiaans JAM, Forsberg MM, Järvinen T, Männistö PT, Wallén EAA. 2006. An introduction of a pyridine group into the structure of prolyl oligopeptidase inhibitors. BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS 16: 5590-5593. 2006
• Venäläinen JI, Garcia-Horsman JA, Forsberg MM, Jalkanen A, Wallén EAA, Jarho EM, Christiaans JAM, Gynther J, Männistö PT. 2006. Binding kinetics and duration of in vivo action of novel prolyl oligopeptidase inhibitors. BIOCHEMICAL PHARMACOLOGY 71 5: 683-692. 2006
• Jarho EM, Wallén EAA, Christiaans JAM, Forsberg MM, Venäläinen JI, Männistö PT, Gynther J, Poso A. 2005. Dicarboxylic acid azacycle L-prolyl-pyrrolidine amides as prolyl oligopeptidase inhibitors and three-dimensional quantitative structure-activity relationship of the enzyme-inhibitor interactions. JOURNAL OF MEDICINAL CHEMISTRY 48: 4772-4782. 2005
• Forsberg MM, Huotari M, Savolainen J, Männistö PT. 2005. The role of physicochemical properties of entacapone and tolcapone on their efficacy during local intrastriatal administration. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 24: 503-511. 2005
• Forsberg M. 2005. Comparison of Pharmacokinetics and Pharmacodynamics of Catechol-O-Methyltransferase (COMT) Inhibitors: Non-Clinical and Safety Aspects. Kuopion yliopiston julkaisuja A. Farmaseuttiset tieteet. 2005
• Jarho EM, Venäläinen JI, Huuskonen J, Christiaans JAM , Garcia-Horsman JA, Forsberg MM, Järvinen T, Gynther J, Männistö PT, Wallén EAA. 2004. A cyclopent-2-enecarbonyl group mimics proline at the P2 position of prolyl oligopeptidase inhibitors. JOURNAL OF MEDICINAL CHEMISTRY 47: 5605-5607. 2004
• Forsberg MM, Juvonen RO, Helisalmi P, Leppänen J, Gogos JA, Karayiorgou M, Männistö PT. 2004. Lack of increased oxidative stress in catechol-O-methyltransferase (COMT)-deficient mice NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY 370: 279-289. 2004
• Forsberg M, Lehtonen M, Heikkinen M, Savolainen J, Järvinen T, Männistö PT. 2003. Pharmacokinetics and pharmacodynamics of entacapone and tolcapone after acute and repeated administration: a comparative study in the rat. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 304 2: 498-506. 2003
• Heimbach T, Oh DM, Li LY, Forsberg M, Savolainen J, Leppänen J, Matsunaga Y, Flynn G, Fleisher D. 2003. Absorption rate limit considerations for oral phosphate prodrugs. PHARMACEUTICAL RESEARCH 20 6: 848-856. 2003
• Wallén EAA, Christiaans JAM, Jarho EM, Forsberg MM, Venäläinen JI, Männistö PT, Gynther J. 2003. New prolyl oligopeptidase inhibitors developed from dicarboxylic acid bis(L-prolyl-pyrrolidine) amides. JOURNAL OF MEDICINAL CHEMISTRY 46: 4543-4551. 2003
• Wallén EAA, Christiaans JAM, Saarinen TJ, Jarho EM, Forsberg MM, Venäläinen JI, Männistö PT, Gynther J. 2003. Conformationally rigid N-Acyl-5-alkyl-L-prolyl-pyrrolidines as prolyl oligopeptidase inhibitors. BIOORGANIC AND MEDICINAL CHEMISTRY 11: 3611-3619. 2003
• Wallén EAA, Christiaans JAM, Forsberg MM, Venäläinen JI, Männistö PT, Gynther J. 2002. Dicarboxylic acid bis(L-prolyl-pyrrolidine) amides as prolyl oligopeptidase inhibitors. JOURNAL OF MEDICINAL CHEMISTRY 45: 4581-4584. 2002
• Wallén EAA, Christiaans JAM, Saario SM, Forsberg MM, Venäläinen JI, Paso HM, Männistö PT, Gynther J. 2002. 4-phenylbutanoyl-2(S)-acylpyrrolidines and 4-phenylbutanoyl-L-prolyl-2(S)-acylpyrrolidines as prolyl oligopeptidase inhibitors. BIOORGANIC AND MEDICINAL CHEMISTRY 10: 2199-2206. 2002
• Huotari M, Gogos JA, Karayiorgou M, Koponen O, Forsberg M, Raasmaja A, Hyttinen J, Männistö PT. 2002. Brain catecholamine metabolism in catechol-0-methyltransferase (COMT)-deficient mice. EUROPEAN JOURNAL OF NEUROSCIENCE (OXFORD) 15: 246-256. 2002
• Venäläinen JI, Juvonen RO, Forsberg MM, Garcia-Horsman A, Poso A, Wallen EAA, Gynther J, Männistö PT. 2002. Substrate-dependent, non-hyperbolic kinetics of pig brain prolyl oligopeptidase and its tight binding inhibition by JTP-4819. BIOCHEMICAL PHARMACOLOGY 64: 463-471. 2002
• Forsberg M, Savolainen J, Järvinen T, Leppänen J, Gynther J, Männistö PT. 2002. Pharmacodynamic response of entacapone in rats after administration of entacapone formulations and prodrugs with varying bioavailabilities. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY 90: 327-332. 2002
• Huotari M, Passlin M, Nordberg H-L, Forsberg M, Kotisaari S, Tuomisto L, Shintani F, Tanaka KF, Reenilä I, Laitinen K, Männistö PT. 2001. Effect of intracerebral 6-nitronoradrenaline, an endogenous catechol-O-methyltransferase (COMT) inhibitor, on striatal dopamine metabolism in anaesthetised rats. JOURNAL OF NEUROSCIENCE METHODS 109: 47-52. 2001
• Keski-Hynnilä H, Raanaa K, Forsberg M, Männistö P, Taskinen J, Kostiainen R. 2001. Quantitation of entacapone glucuronide in rat plasma by on-line coupled restricted access media column and liquid chromatography-tandem mass spectrometry JOURNAL OF CHROMATOGRAPHY. B. ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 759: 227-236. 2001
• Leppänen J, Savolainen J, Nevalainen T, Forsberg M, Huuskonen J, Taipale H, Gynther J, Männistö PT, Järvinen T. 2001. Synthesis and in-vitro/in-vivo evaluation of orally administered entacapone prodrugs. JOURNAL OF PHARMACY AND PHARMACOLOGY 53: 1489-1498. 2001
• Savolainen J, Forsberg M, Taipale H, Männistö PT, Järvinen K, Gynther J, Jarho P, Järvinen T. 2000. Effects of aqueous solubility and dissolution characteristics on oral bioavailability of entacapone. DRUG DEVELOPMENT RESEARCH 49: 238-244. 2000
• Savolainen J, Leppanen J, Forsberg M, Taipale H, Nevalainen T, Huuskonen J, Gynther J, Mannisto PT, Jarvinen T. 2000. Synthesis and in vitro/in vivo evaluation of novel oral N-alkyl- and N,N-dialkyl-carbamate esters of entacapone. LIFE SCIENCES 67: 205-216. 2000