MINNA RAHNASTO-RILLA

Yliopistotutkija

Yhteystiedot

Organisaatio

Terveystieteiden tiedekunta, Farmasian laitos

Sähköposti

minna.rahnasto@uef.fi

Puhelin

040 355 3786

Tutkimusryhmät - UEF

Julkaisut

Tenhunen, Jonna; Kucera, Tomáš; Huovinen, Marjo; Küblbeck, Jenni; Bisenieks, Egils; Vigante, Brigita; Ogle, Zaiga; Duburs, Gunars; Doležal, Martin; Moaddel, Ruin; Lahtela-Kakkonen, Maija; Rahnasto-Rilla, Minna. 2021. Screening of SIRT6 inhibitors and activators: A novel activator has an impact on breast cancer cells Biomedicine and pharmacotherapy 138: 111452. 2021
Sirtuin Inhibitors and Activators. Rahnasto-Rilla, Minna; Tyni, Jonna; Lahtela-Kakkonen, Maija / Chemical Epigenetics. 2020. 2020
Tenhunen, Jonna; Kokkola, Tarja; Huovinen, Marjo; Rahnasto-Rilla, Minna; Lahtela-Kakkonen, Maija. 2020. Impact of Structurally Diverse BET Inhibitors on SIRT1 Gene 741: 144558. 2020
Rahnasto-Rilla, Minna; Järvenpää, Joni; Huovinen, Marjo; Schroderus, Anna-Mari; Ihantola, Emmi-Leena; Küblbeck, Jenni; Khadeer, Mohammed; Moaddel, Ruin; Lahtela-Kakkonen, Maija. 2020. Effects of galloflavin and ellagic acid on sirtuin 6 and its anti-tumorigenic activities Biomedicine and pharmacotherapy 131: 110701. 2020
Giantin, M; Rahnasto-Rilla, M; Tolosi, R; Lucatello, L; Pauletto, M; Guerra, G; Pezzato, F; Lopparelli, RM; Merlanti, R; Carnier, P; Capolongo, F; Honkakoski, P; Dacasto, M. 2019. Functional impact of cytochrome P450 3A (CYP3A) missense variants in cattle Scientific reports 9 1: 19672. 2019
Heger, Vladimír; Tyni, Jonna; Hunyadi, Attila; Horáková, Lubica; Lahtela-Kakkonen, Maija; Rahnasto-Rilla, Minna. 2019. Quercetin based derivatives as sirtuin inhibitors Biomedicine and pharmacotherapy 111: 1326-1333. 2019
Rahnasto-Rilla, M; Tyni, J; Huovinen, M; Jarho, E; Kulikowicz, T; Ravichandran, S; Bohr, VA; Ferrucci, L; Lahtela-Kakkonen, M; Moaddel R. 2018. Natural polyphenols as sirtuin 6 modulators. Scientific Reports 8: 4163. 2018
Rahnasto-Rilla Minna K, McLoughlin Padraig, Kulikowicz Tomasz, Doyle Maire, Bohr Vilhelm A, Lahtela-Kakkonen Maija, Ferrucci Luigi, Hayes Maria, Moaddel Ruin. 2017. The Identification of a SIRT6 Activator from Brown Algae Fucus distichus. Marine Drugs 15 6: 190. 2017
Rahnasto-Rilla Minna, Lahtela-Kakkonen Maija, Moaddel Ruin. 2016. Sirtuin 6 (SIRT6) Activity Assays. Teoksessa: Sarkar Sibaji (toim.) Histone Deacetylases : Methods and Protocols, Part II. Springer. Methods in Molecular Biology 1436. s. 259-269. 2016
Raunio Hannu, Juvonen Risto O, Poso Antti, Lahtela-Kakkonen Maija, Rahnasto-Rilla Minna. 2016. Common and Distinct Interactions of Chemical Inhibitors with Cytochrome P450 CYP1A2, CYP2A6 and CYP2B6 Enzymes. Drug Metabolism Letters 10 1: 56-64. 2016
Fashe Muluneh M, Juvonen Risto O, Petsalo Aleksanteri, Vepsäläinen Jouko, Pasanen Markku, Rahnasto-Rilla Minna. 2015. In Silico Prediction of the Site of Oxidation by Cytochrome P450 3A4 That Leads to the Formation of the Toxic Metabolites of Pyrrolizidine Alkaloids. CHEMICAL RESEARCH IN TOXICOLOGY 28 4: 702-710. 2015
Rahnasto-Rilla Minna, Kokkola Tarja, Jarho Elina, Lahtela-Kakkonen Maija, Moaddel Ruin. 2015. N-Acylethanolamines Bind to SIRT6. CHEMBIOCHEM : A EUROPEAN JOURNAL OF CHEMICAL BIOLOGY 17 (2016) 1: 77-81. 2015
Salminen Kaisa A, Rahnasto-Rilla Minna, Vaananen Raija, Imming Peter, Meyer Achim, Horling Aline, Poso Antti, Laitinen Tuomo, Raunio Hannu, Lahtela-Kakkonen Maija. 2015. Time-dependent inhibition of CYP2C19 by isoquinoline alkaloids: in vitro and in silico analysis. DRUG METABOLISM AND DISPOSITION 43: 1891-1904. 2015
Raunio Hannu, Pasanen Markku, Juvonen Risto, Rahnasto-Rilla Minna, Tani Niina, Hukkanen Kaisa, Huuskonen Pasi, Muluneh Fashe. 2014. Vierasaineiden metabolia. DOSIS : FARMASEUTTINEN AIKAKAUSKIRJA 30 3: 208. 2014
Tani Niina, Juvonen Risto O, Raunio Hannu, Fashe Muluneh, Leppänen Jukka, Zhao Bin, Tyndale Rachel F, Rahnasto-Rilla Minna. 2014. Rational design of novel CYP2A6 inhibitors. BIOORGANIC AND MEDICINAL CHEMISTRY 22 23: 6655-6664. 2014
Kokkonen Piia, Rahnasto-Rilla Minna, Mellini Paolo, Jarho Elina, Lahtela-Kakkonen Maija, Kokkola Tarja. 2014. Studying SIRT6 regulation using H3K56 based substrate and small molecules. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 63: 71-76. 2014
Fashe Muluneh M, Juvonen Risto O, Petsalo Aleksanteri, Rahnasto-Rilla Minna, Auriola Seppo, Soininen Pasi, Vepsäläinen Jouko, Pasanen Markku. 2014. Identification of a New Reactive Metabolite of Pyrrolizidine Alkaloid Retrorsine: (3H-Pyrrolizin-7-yl)methanol. CHEMICAL RESEARCH IN TOXICOLOGY 27: 1950-1957. 2014
Kokkonen Piia, Mellini Paolo, Nyrhilä Olli, Rahnasto-Rilla Minna, Suuronen Tiina, Kiviranta Päivi, Huhtiniemi Tero, Poso Antti, Jarho Elina, Lahtela-Kakkonen Maija. 2014. Quantitative insights for the design of substrate-based SIRT1 inhibitors. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 59: 12-19. 2014
Martikainen Laura E, Rahnasto-Rilla Minna, Neshybova Silvie, Lahtela-Kakkonen Maija, Raunio Hannu, Juvonen Risto O. 2012. Interactions of inhibitor molecules with the human CYP2E1 enzyme active site. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 47 5: 996-1005. 2012
Raunio Hannu, Rahnasto-Rilla Minna. 2012. CYP2A6: genetics, structure, regulation, and function Drug Metabolism and Drug Interactions 27 2: 73-88. 2012
Piia Kokkonen, Minna Rahnasto-Rilla, Päivi Kiviranta, Tero Huhtiniemi, Tuomo Laitinen, Antti Poso, Elina Jarho, Maija Lahtela-Kakkonen. 2012. Peptides and Pseudopeptides as SIRT6 Inhibitors. Teoksessa: (toim.), EFMC-ISMC 2012 22nd International Symposium on Medicinal Chemistry Berlin, Germany, September 2.-6., 2012. ss. -. 2012
Tani Niina, Rahnasto-Rilla Minna, Wittekindt Carsten, Salminen Kaisa A, Ritvanen Anniina, Ollakka Riina, Koskiranta Jenna, Raunio Hannu, Juvonen Risto O. 2012. Antifungal activities of novel non-azole molecules against S. cerevisiae and C. albicans EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 47: 270-277. 2012
Kokkonen Piia, Rahnasto-Rilla Minna, Kiviranta Päivi H, Huhtiniemi Tero, Laitinen Tuomo, Poso Antti, Jarho Elina, Lahtela-Kakkonen Maija. 2012. Peptides and pseudopeptides as SIRT6 deacetylation inhibitors. ACS Medicinal Chemistry Letters 3: 969-974. 2012
Fashe Muluneh, Petsalo Aleksanteri, Juvonen Risto O, Rahnasto-Rilla Minna, Pasanen Markku, Auriola Seppo. 2012. Comparison of Electrochemical and Biological Oxidation of Pyrrolizidine Alkaloid Retrorsine. Teoksessa: (toim.), FinPharma Doctoral Program (FPDP): 6th Joint Meeting at the University of Turku, August 16-17, 2012, Turku, Finland. ss. 28:328. 2012
Abu-Bakar A'edah, Hakkola Jukka, Juvonen Risto, Rahnasto-Rilla Minna, Raunio Hannu, Lang Matti A. 2012. Function and regulation of the Cyp2a5/CYP2A6 genes in response to toxic insults in the liver. CURRENT DRUG METABOLISM 2013:14: 137-150. 2012
Abu-Bakar A'edah, Arthur Dionne M, Wikman Anna S, Rahnasto Minna, Juvonen Risto O, Vepsäläinen Jouko, Raunio Hannu, Ng Jack C, Lang Matti A. 2012. Metabolism of bilirubin by human cytochrome P450 2A6. TOXICOLOGY AND APPLIED PHARMACOLOGY 261: 50-58. 2012
Rahnasto Minna K, Raunio Hannu A, Wittekindt Carsten, Salminen Kaisa A, Leppänen Jukka, Juvonen Risto O, Poso Antti, Lahtela-Kakkonen Maija K. 2011. Identification of novel CYP2A6 inhibitors by virtual screening BIOORGANIC AND MEDICINAL CHEMISTRY 19: 7186-7193. 2011
Salminen Kaisa A, Meyer Achim, Jerabkova Lenka, Korhonen Laura E, Rahnasto Minna, Juvonen Risto O, Imming Peter, Raunio Hannu. 2011. Inhibition of human drug metabolizing cytochrome P450 enzymes by plant isoquinoline alkaloids. PHYTOMEDICINE 18: 533 - 538. 2011
Rahnasto M. 2009. Development of Inhibitors of the Human CYP2A6 Enzyme. in vitro and in silico Study. Kuopion yliopiston julkaisuja A. Farmaseuttiset tieteet. 2009
Rahnasto M, Wittekindt C, Juvonen RO, Turpeinen M, Petsalo A, Pelkonen O, Poso A, Stahl G, Höltje H-D, Raunio H. 2008. Identification of inhibitors of the nicotine metabolising CYP2A6 enzyme-an in silico approach PHARMACOGENOMICS JOURNAL 8 5: 328-338. 2008
Raunio H, Pokela N, Puhakainen K, Rahnasto M, Mauriala T, Auriola S, Juvonen RO. 2008. Nicotine metabolism and urinary elimination in mouse: in vitro and in vivo XENOBIOTICA (LONDON) 38 1: 34-47. 2008
Korhonen LE, Turpeinen M, Rahnasto M, Wittekindt C, Poso A, Pelkonen O, Raunio H, Juvonen RO. 2007. New potent and selective cytochrome P450 2B6 (CYP2B6) inhibitors based on three-dimensional quantitative structure-activity relationship (3D-QSAR) analysis. BRITISH JOURNAL OF PHARMACOLOGY 150: 932-942. 2007
Korhonen LE, Rahnasto M, Mähönen N J, Wittekindt C, Poso A, Juvonen RO, Raunio H. 2005. Predictive three-dimensional quantitative structure-activity relationship of cytochrome P450 1A2 inhibitors. JOURNAL OF MEDICINAL CHEMISTRY 48: 3808-3815. 2005
Rahnasto M, Raunio H, Poso A, Wittekindt C, Juvonen RO. 2005. Quantitative structure - activity relationship analysis of inhibitors of the nicotine metabolizing CYP2A6 enzyme. JOURNAL OF MEDICINAL CHEMISTRY 48: 440-449. 2005
Rahnasto M, Raunio H, Poso A, Juvonen RO. 2003. More potent inhibition of human CYP2A6 than mouse CYP2A5 enzyme activities by derivatives of phenylethylamine and benzaldehyde. XENOBIOTICA (LONDON) 33 5: 529-539. 2003