OSSI KORHONEN

Yhteystiedot

Tutkimusryhmät

• Amorfiset formulaatiot
• Biologisten lääkkeiden kylmäkuivaus
• Farmasian teknologia
• Jatkuvatoiminen lääkevalmistus
• Lääkevalmisteiden 3D tulostaminen

Julkaisut

• Ervasti, Tuomas; Niinikoski, Hannes;, Mäki-Lohiluoma, Eero; Leppinen, Heidi; Ketolainen, Jarkko; Korhonen, Ossi; Lakio, Satu. 2020. The Comparison of Two Challenging Low Dose APIs in a Continuous Direct Compression Process Pharmaceutics 12 3: 279. 2020
• Taipale-Kovalainen, Krista; Ketolainen, Jarkko; Korhonen, Ossi; Ervasti, Tuomas. 2020. Converting a batch based high-shear granulation process to a continuous dry granulation process; a demonstration with ketoprofen tablets European journal of pharmaceutical sciences 151: 105381. 2020
• Viidik, Laura; Vesala, Jemina; Laitinen, Riikka; Korhonen, Ossi; Ketolainen, Jarkko; Aruväli, Jaan; Kirsimäe, Kalle; Kogermann, Karin; Heinämäki, Jyrki; Laidmäe, Ivo; Ervasti, Tuomas. 2020. Preparation and characterization of hot-melt extruded polycaprolactone-based filaments intended for 3D-printing of tablets European journal of pharmaceutical sciences In Press Journal Pre-proof 29.10.20: 1-27. 2020
• Kilpeläinen, Tuomas ; Pajula, Katja ; Ervasti, Tuomas ; Uurasjärvi, Emilia ; Koistinen, Arto ; Korhonen, Ossi. 2020. Raman imaging of amorphous-amorphous phase separation in small molecule co-amorphous systems European journal of pharmaceutics and biopharmaceutics 155: 49-54. 2020
• Korhonen, Ossi. 2020. Continuous Pharmaceutical Manufacturing Pharmaceutics 12 10: 910. 2020
• Pajula, Katja; Hyyryläinen, Juha; Koistinen, Arto; Leskinen, Jari T T; Korhonen, Ossi. 2020. Detection of amorphous-amorphous phase separation in small molecular co-amorphous mixtures with SEM-EDS European journal of pharmaceutics and biopharmaceutics 150: 43-49. 2020
• Hakkarainen, E; Kõrkjas, A; Laidmäe, I; Lust, A; Semjonov, K; Kogermann, K; Nieminen, HJ; Salmi, A; Korhonen, O; Haeggström, E; Heinämäki, J. 2019. Comparison of Traditional and Ultrasound-Enhanced Electrospinning in Fabricating Nanofibrous Drug Delivery Systems Pharmaceutics 11 10: 495. 2019
• Karttunen, A-P; Poms, J; Sacher, S; Sparén, A; Ruiz Samblás, C; Fransson, M; Martin De Juan, L; Remmelgas, J; Wikström, H; Hsiao, W K; Folestad, S; Korhonen, O; Abrahmsén-Alami, S; Tajarobi, P. 2019. Robustness of a continuous direct compression line against disturbances in feeding International journal of pharmaceutics 2020; 574: 118882. 2019
• Karttunen, AP; Hörmann, TR; De Leersnyder, F; Ketolainen, J; De Beer, T; Hsiao, WK; Korhonen, O. 2019. Measurement of residence time distributions and material tracking on three continuous manufacturing lines International journal of pharmaceutics 563: 184-197. 2019
• Karttunen, AP; Wikström, H; Tajarobi, P; Fransson, M; Sparén, A; Marucci, M; Ketolainen, J; Folestad, S; Korhonen, O; Abrahmsén-Alami, S. 2019. Comparison between integrated continuous direct compression line and batch processing - The effect of raw material properties European journal of pharmaceutical sciences 133: 40-53. 2019
• Rehrl, Jakkob; Karttunen, Anssi-Pekka; Nicolaï, Niels; Hörmann, Theresa; Horn, Martin; Korhonen, Ossi; Nopens, Ingmar; De Beer, Thomas; Khinast, Johannes G. 2018. Control of three different continuous pharmaceutical manufacturing processes: Use of soft sensors. INTERNATIONAL JOURNAL OF PHARMACEUTICS 543 1-2: 60-72. 2018
• Taipale-Kovalainen, Krista; Karttunen, Anssi-Pekka; Niinikoski, Hannes; Ketolainen, Jarkko; Korhonen, Ossi. 2018. The effects of unintentional and intentional process disturbances on tablet quality during long continuous manufacturing runs EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 2019; 129: 10-20. 2018
• Martinetz, MC; Karttunen, AP; Sacher, S; Wahl, P; Ketolainen, J; Khinast, JG; Korhonen, O. 2018. RTD-based Material Tracking in a Fully-Continuous Dry Granulation Tableting Line INTERNATIONAL JOURNAL OF PHARMACEUTICS 547 1-2: 469-479. 2018
• Lajunen, T; Nurmi, R; Wilbie, D; Ruoslahti, T; Johansson, NG; Korhonen, O; Rog, T; Bunker, A; Ruponen, M; Urtti, A. 2018. The effect of light sensitizer localization on the stability of indocyanine green liposomes JOURNAL OF CONTROLLED RELEASE 284: 213-223. 2018
• Bawuah, Prince; Karttunen, Anssi-Pekka; Markl, Daniel; Ridgway, Cathy; Korhonen, Ossi; Gane, Patrick; Zeitler, J Axel; Ketolainen, Jarkko; Peiponen, Kai-Erik. 2018. Investigating elastic relaxation effects on the optical properties of functionalised calcium carbonate compacts using optics-based Heckel analysis INTERNATIONAL JOURNAL OF PHARMACEUTICS 544 1: 278-284. 2018
• Ojarinta, Rami; Saarinen, Jukka; Strachan, Clare J; Korhonen, Ossi; Laitinen, Riikka. 2018. Preparation and characterization of multi-component tablets containing co-amorphous salts: combining multimodal non-linear optical imaging with established analytical methods European journal of pharmaceutics and biopharmaceutics 132: 112-126. 2018
• Christensen JR, Meng-Lund H, Grohganz H, Poso A, Laitinen T, Korhonen O, Jørgensen L, Pajander J. 2017. Surface area, volume and shape descriptors as a novel tool for polymer lead design and discovery. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 102: 188-195. 2017
• Korhonen Kristiina, Smolander Elina, Korhonen Ossi, Ketolainen Jarkko, Laitinen Riikka. 2017. Effect of storage on the physical stability of thin polymethacrylate-perphenazine films. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 104: 293-301. 2017
• Lakio S, Ervasti T, Tajarobi P, Wikström H, Fransson M, Karttunen AP, Ketolainen J, Folestad S, Abrahmsén-Alami S, Korhonen O. 2017. Provoking an end-to-end continuous direct compression line with raw materials prone to segregation. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 109: 514-524. 2017
• Laske S, Paudel A, Scheibelhofer O, Sacher S, Hoermann T, Khinast J, Kelly A, Rantannen J, Korhonen O, Stauffer F, De Leersnyder F, De Beer T, Mantanus J, Chavez PF, Thoorens B, Ghiotti P, Schubert M, Tajarobi P, Haeffler G, Lakio S et al.. 2017. A Review of PAT Strategies in Secondary Solid Oral Dosage Manufacturing of Small Molecules. JOURNAL OF PHARMACEUTICAL SCIENCES 106 3: 667-712. 2017
• Taipale-Kovalainen Krista, Karttunen Anssi-Pekka, Ketolainen Jarkko, Korhonen Ossi. 2017. Lubricant based determination of design space for continuously manufactured high dose paracetamol tablets. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 2018; 115: 1-10. 2017
• Korhonen Kristiina, Poikolainen Mirja, Korhonen Ossi, Ketolainen Jarkko, Laitinen Riikka. 2016. Systematic evaluation of a spraying method for preparing thin Eudragit-drug films by Design of Experiments. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY 35: 241-251. 2016
• Korhonen Ossi, Pajula Katja, Laitinen Riikka. 2016. Rational excipient selection for co-amorphous formulations. EXPERT OPINION ON DRUG DELIVERY 2017; 14 4: 551-569. 2016
• Simonaho Simo-Pekka, Ketolainen Jarkko, Ervasti Tuomas, Toiviainen Maunu, Korhonen Ossi. 2016. Continuous manufacturing of tablets with PROMIS-line - Introduction and case studies from continuous feeding, blending and tableting. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 90: 38-46. 2016
• Ketolainen Jarkko, Korhonen Ossi, Laitinen Riikka, Simonaho Simo-Pekka, Molnár Ferdinand. 2014. Pharmaceutical solids and processes. DOSIS : FARMASEUTTINEN AIKAKAUSKIRJA 30 3: 195. 2014
• Pajula Katja, Wittoek Lieke, Lehto Vesa-Pekka, Ketolainen Jarkko, Korhonen Ossi. 2014. Phase separation in co-amorphous systems: in silico prediction and the experimental challenge of detection. Molecular Pharmaceutics 11: 2271-2279. 2014
• Kauppinen Ari, Toiviainen Maunu, Korhonen Ossi, Aaltonen Jaakko, Järvinen Kristiina, Paaso Janne, Juuti Mikko, Ketolainen Jarkko. 2013. In-line multipoint near-infrared spectroscopy for moisture content quantification during freeze-drying. ANALYTICAL CHEMISTRY 85: 2377-2384. 2013
• Turunen Elina, Korhonen Ossi, Lehto Vesa-Pekka, Kauppinen Ari, Ahtiainen Hanne, Järvinen Kristiina, Jarho Pekka. 2013. Effect of storage on the dissolution rate of a fast-dissolving perphenazine/β-cyclodextrin complex. JOURNAL OF PHARMACY AND PHARMACOLOGY 2014:66: 367-377. 2013
• Kauppinen Ari, Toiviainen Maunu, Aaltonen Jaakko, Korhonen Ossi, Järvinen Kristiina, Juuti Mikko, Pellinen Riikka, Ketolainen Jarkko. 2013. Microscale freeze-drying with Raman spectroscopy as a tool for process development. ANALYTICAL CHEMISTRY 85: 2109-2116. 2013
• Kauppinen Ari, Toiviainen Maunu, Aaltonen Jaakko, Korhonen Ossi, Järvinen Kristiina, Juuti Mikko, Pellinen Riikka, Ketolainen Jarkko. 2013. Micro-scale freeze-drying with Raman spectroscopy as a tool for process development. Teoksessa: (toim.), The XXIV Symposium of the Finnish Society of Physical Pharmacy. ss. 23-24. 2013
• Kauppinen Ari, Toiviainen Maunu, Korhonen Ossi, Aaltonen Jaakko, Järvinen Kristiina, Juuti Mikko, Ketolainen Jarkko. 2012. Freeze drying formulation and process design using Raman spectrometer equipped micro scale freeze drying stage. Teoksessa: (toim.), EuPAT5. ss. 57. 2012
• Kauppinen Ari, Toiviainen Maunu, Korhonen Ossi, Aaltonen Jaakko, Järvinen Kristiina, Juuti Mikko, Ketolainen Jarkko. 2012. In-line moisture content monitoring of the freeze dried products using multipoint NIR spectroscopy. Teoksessa: (toim.), EuPAT5. ss. 57. 2012
• Löbmann Korbinian, Strachan Clare, Grohganz Holger, Rades Thomas, Korhonen Ossi, Laitinen Riikka. 2012. Co-amorphous simvastatin and glipizide combinations show improved physical stability without evidence of intermolecular interactions. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 81: 159-169. 2012
• Pajula Katja, Lehto Vesa-Pekka, Ketolainen Jarkko, Korhonen Ossi. 2012. Computational approach for fast screening of small molecular candidates to inhibit crystallization in amorphous drugs Molecular Pharmaceutics 9: 2844-2855. 2012
• Riikonen Joakim, Salomäki Mikko, van Wonderen Jessica , Kemell Marianna, Xu, Wujun, Korhonen Ossi, Ritala Mikko, MacMillan Fraser, Salonen Jarno, Lehto Vesa-Pekka. 2012. Surface Chemistry, Reactivity, and Pore Structure of Porous Silicon Oxidized by Various Methods. LANGMUIR 28 28: 10573−10583. 2012
• Kauppinen Ari, Toiviainen Maunu, Aaltonen Jaakko, Korhonen Ossi, Järvinen Kristiina, Ketolainen Jarkko. 2011. Determination of water content in freeze dried samples using NIR spectroscopy, The XXII Symposium of the Finnish Society of Physical Pharmacy. 26. 2011
• Kauppinen Ari, Pellinen Riika, Karjalainen Mikko, Korhonen Ossi, Aaltonen Jaakko, Heikkilä Katri, Järvinen Kristiina, Nokelainen Minna, Ketolainen Jarkko. 2010. Design of freeze drying process for an adenovirus vector. Teoksessa: (toim.), EuPAT4. ss. 29. 2010
• Kauppinen Ari, Reinisalo Mika, Pellinen Riikka, Korhonen Ossi, Järvinen Kristiina, Ketolainen Jarkko. 2010. Effect of freeze-drying conditions on transfection efficiency of cationic polymer DNA complexes. Teoksessa: (toim.), The XXI Symposium of the Finnish Society of Physical Pharmacy. ss. 50. 2010
• Pajula K, Taskinen M, Lehto V-P, Ketolainen J & Korhonen O. 2010. Predicting the formation and stability of amorphous small molecule binary mixtures from computationally determined Flory-Huggins interaction parameter and phase diagram. Molecular Pharmaceutics 7 3: 795-804. 2010
• Kauppinen Ari, Reinisalo Mika, Pellinen Riikka, Gieseler Henning, Schneid Stefan, Rutzinger Susanne, Beirowski Jakob, Korhonen Ossi, Järvinen Kristiina, Ketolainen Jarkko. 2009. Determining the critical properties of formulations for freeze drying by DSC and FDM, 4th FinPharmaNet. 1. 2009
• Pajander J, Korhonen O, Laamanen M, Ryynänen E-L, Grimsey I, Van Veen B, Ketolainen J. 2009. Effect of formulation parameters and drug-polymer interactions on drug release from starch acetate matrix tablets. JOURNAL OF PHARMACEUTICAL SCIENCES 98 10: 3676-3690. 2009
• Pajander J, Soikkeli A, Korhonen O, Forbes RT, Ketolainen J. 2008. Drug release phenomena within a hydrophobic starch acetate matrix: FTIR mapping of tablets after in vitro dissolution testing. JOURNAL OF PHARMACEUTICAL SCIENCES 97 8: 3367-3378. 2008
• Matero S, Reinikainen S-P, Lahtela-Kakkonen M, Korhonen O, Ketolainen J, Poso A. 2008. Estimation of drug release profiles of a heterogeneous set of drugs from a hydrophobic matrix tablet using molecular descriptors JOURNAL OF CHEMOMETRICS 22: 653-660. 2008
• Korhonen O, Bhugra C, Pikal MJ. 2008. Correlation between molecular mobility and crystal growth of amorphous phenobarbital and phenobarbital with polyvinylpyrrolidone and L-proline. JOURNAL OF PHARMACEUTICAL SCIENCES 97 9: 3830-3841. 2008
• Matero S, Pajander J, Soikkeli A-M, Reinikainen S-P, Lahtela-Kakkonen M, Korhonen O, Ketolainen J, Poso A. 2007. Predicting the drug concentration in starch acetate matrix tablets from ATR-FTIR spectra using multi-way methods ANALYTICA CHIMICA ACTA (AMSTERDAM) 595: 190-197. 2007
• Matero S, Lahtela-Kakkonen M, Korhonen O, Ketolainen J, Lappalainen R, Poso A. 2006. Chemical space of orally active compounds. CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS 84: 134-141. 2006
• Mäki R, Suihko E, Korhonen O, Pitkänen H, Niemi R, Lehtonen M, Ketolainen J. 2006. Controlled release of saccharides from matrix tablets. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 62: 163-170. 2006
• Pajander J, van Veen B, Korhonen O, Lappalainen R, Ketolainen J. 2006. Liquid boundary movements in cylindrical and convex hydrophobic matrix tablets: effects on tablet cracking and drug release. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 64: 167-172. 2006
• Korhonen O, Matero S, Poso A, Ketolainen J. 2005. Partial least square projections to latent structures analysis (PLS) in evaluating and predicting drug release from starch acetate matrix tablets JOURNAL OF PHARMACEUTICAL SCIENCES 94 12: 2716-2730. 2005
• Suihko E, Forbes RT, Korhonen O, Ketolainen J, Paronen P, Gynther J, Poso A. 2005. Prediction of contact angle for pharmaceutical solids from their molecular structure. JOURNAL OF PHARMACEUTICAL SCIENCES 94 4: 745-758. 2005
• Korhonen O, Kanerva H, Vidgren M, Urtti A, Ketolainen J. 2004. Evaluation of novel starch acetate-diltiazem controlled release tablets in healthy human volunteers. JOURNAL OF CONTROLLED RELEASE 95: 515-520. 2004
• Korhonen O. 2004. Starch Acetate as a Novel Tablet Excipient for Extended Oral Drug Delivery. Kuopion yliopiston julkaisuja A. Farmaseuttiset tieteet. 2004
• Korhonen O, Pohja S, Peltonen S, Suihko E, Vidgren M, Paronen P, Ketolainen J. 2002. Effects of physical properties for starch acetate powders on tableting [online]. AAPS PHARMSCITECH [ONLINE: HTTP://WWW.AAPSPHARMSCITECH.ORG/] 3 4: [21.2.2003]. 2002
• Raatikainen P, Korhonen O, Peltonen S, Paronen P. 2002. Acetylation enhances the tabletting properties of starch. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY 28 2: 165-175. 2002
• Suihko E, Korhonen O, Järvinen T, Ketolainen J, Jarho P, Laine E, Paronen P. 2001. Complexation with tolbutamide modifies the physicochemical and tableting properties of hydroxypropyl-beta-cyclodextrin. INTERNATIONAL JOURNAL OF PHARMACEUTICS 215: 137-145. 2001
• Korhonen O, Raatikainen P, Harjunen P, Nakari J, Suihko E, Peltonen S, Vidgren M, Paronen P. 2000. Starch acetates - multifunctional direct compression excipients. PHARMACEUTICAL RESEARCH 17 9: 1138-1143. 2000
• Suihko E, Poso A, Korhonen O, Gynther J, Ketolainen J, Paronen P. 2000. Deformation behaviors of tolbutamide, hydroxypropyl-beta-cyclodextrin, and their dispersions. PHARMACEUTICAL RESEARCH 17 8: 942-948. 2000
• Korhonen O. 1997. Menetelmiä hiukkasten muokkaamisesta suorapuristukseen. POLYMORFI 2: 7-9. 1997
• Suihko E, Korhonen O, Järvinen T, Ketolainen J, Laine E, Paronen P. 1997. Evaluation of physical properties of tolbutamide/hydroxypropyl-ß-cyclodextrin inclusion complex. Teoksessa: (toim.), 16th Pharmaceutical Technology Conference and Exhibition. Vol. 2.. ss. 286-294. 1997