PAAVO HONKAKOSKI

Yhteystiedot

Avainsanat

Opetustehtävät

Tutkimusryhmät - UEF

• 
  EDCMET
• 
  Itä-Suomen Genomikeskus
• 
  Lääke- ja vierasaineiden metabolia ja kuljetus
• 
  Silmälääketutkimusryhmä

Linkit

• LinkedIn Tietoni LinkedIn-palvelussa
• Research gate Kuvaus Researchgate-tietokannassa
• Orcid Profiili ja julkaisut ORCID-tietokannassa
• Linkki Julkaisuni PubMed-tietokannassa

Julkaisut

• del Amo, Eva M.; Hammid, Anam; Tausch, Melanie; Toropainen, Elisa; Sadeghi, Amir; Valtari, Annika; Puranen, Jooseppi; Reinisalo, Mika; Ruponen, Marika; Urtti, Arto; Sauer, Achim; Honkakoski, Paavo. 2022. Ocular metabolism and distribution of drugs in the rabbit eye: Quantitative assessment after intracameral and intravitreal administrations International journal of pharmaceutics 613: 121361. 2022
• Saran, Chitra; Sundqvist, Louise; Ho, Henry; Niskanen, Jonna; Honkakoski, Paavo; Brouwer, Kim LR. 2022. Novel Bile Acid-dependent Mechanisms of Hepatotoxicity Associated with Tyrosine Kinase Inhibitors Journal of pharmacology and experimental therapeutics 380 2: 114-125. 2022
• Hammid, Anam; Fallon, John K; Lassila, Toni; Salluce, Giulia; Smith, Philip C; Tolonen, Ari; Sauer, Achim; Urtti, Arto; Honkakoski, Paavo. 2021. Carboxylesterase Activities and Protein Expression in Rabbit and Pig Ocular Tissues Molecular pharmaceutics 18 3: 1305-1316. 2021
• Mechanism-Based Experimental Models for the Evaluation of BSEP Inhibition and DILI. Murphy, William A.; Chitra, Saran; Honkakoski, Paavo; Brouwer, Kim L.R. / Transporters and Drug-Metabolizing Enzymes in Drug Toxicity. 2021. 2021
• Murphy, William A.; Beaudoin, James J.; Laitinen, Tuomo; Sjöstedt, Noora; Malinen, Melina M.; Ho, Henry; Swaan, Peter W.; Honkakoski, Paavo; Brouwer, Kim L.R.. 2021. Identification of Key Amino Acids that Impact Organic Solute Transporter Alpha/Beta (OSTα/ß) Molecular pharmacology 100 6: 599-608. 2021
• Huber, Nadine; Korhonen, Sonja; Hoffmann, Dorit; Leskelä, Stina; Rostalski, Hannah; Remes, Anne M.; Honkakoski, Paavo; Solje, Eino; Haapasalo, Annakaisa. 2021. Deficient neurotransmitter systems and synaptic function in frontotemporal lobar degeneration-Insights into disease mechanisms and current therapeutic approaches Molecular psychiatry Published online: 19 November 2021: 1 - 10. 2021
• Küblbeck, Jenni; Niskanen, Jonna; Honkakoski, Paavo. 2020. Metabolism-Disrupting Chemicals and the Constitutive Androstane Receptor CAR Cells 9 10: 2306. 2020
• Küblbeck, Jenni; Vuorio, Taina; Niskanen, Jonna; Fortino, Vittorio; Braeunin, Albert; Abass, Khaled; Rautio, Arja; Hakkola, Jukka; Honkakoski, Paavo; Levonen, Anna-Liisa. 2020. The EDCMET project: Metabolic effects of endocrine disruptors International journal of molecular sciences 21 8: 3021. 2020
• A Reverse Transfection Method for Screening of Nuclear Receptor Activators. Küblbeck, Jenni; Honkakoski, Paavo / Nuclear Receptors. 2019. 2019
• Giantin, M; Küblbeck, J; Zancanella, V; Prantner, V; Sansonetti, F; Schoeniger, A; Tolosi, R; Guerra, G; Da Ros, S; Dacasto, M; Honkakoski, P. 2019. DNA elements for constitutive androstane receptor- and pregnane X receptor-mediated regulation of bovine CYP3A28 gene PLoS ONE 14 3: e0214338. 2019
• Giantin, M; Rahnasto-Rilla, M; Tolosi, R; Lucatello, L; Pauletto, M; Guerra, G; Pezzato, F; Lopparelli, RM; Merlanti, R; Carnier, P; Capolongo, F; Honkakoski, P; Dacasto, M. 2019. Functional impact of cytochrome P450 3A (CYP3A) missense variants in cattle Scientific reports 9 1: 19672. 2019
• Kang, HE; Malinen, MM; Saran, C; Honkakoski, P; Brouwer, KLR. 2019. Optimization of Canalicular ABC Transporter Function in HuH-7 Cells by Modification of Culture Conditions Drug metabolism and disposition 47 10: 1222-1230. 2019
• Malinen, MM; Ito, K; Kang, HE; Honkakoski, P; Brouwer, KLR. 2019. Protein expression and function of organic anion transporters in short-term and long-term cultures of Huh7 human hepatoma cells European journal of pharmaceutical sciences 130: 186-195. 2019
• Touloupi, K; Kublbeck, J; Magklara, A; Molnar, F; Reinisalo, M; Konstandi, M; Honkakoski, P; Pappas, P. 2019. The basis for strain-dependent rat aldehyde dehydrogenase 1A7 (ALDH1A7) gene expression Molecular pharmacology 96 5: 655-663. 2019
• Suun kautta otettujen lääkeaineiden imeytyminen. Urtti, Arto; Ruponen, Marika; Pajula, Katja; Yliperttula, Marjo; Honkakoski, Paavo; Ranta, Veli-Pekka; Kidron, Heidi; Vellonen, Kati-Sisko / Biofarmasian perusteet. 2018. 2018
• Ruponen, Marika; Pajula, Katja; Honkakoski, Paavo; Urtti, Arto (toim.). 2018. Biofarmasian perusteet. Farmasian opiskelijayhdistys Fortis ry. 2018
• Bioekvivalenssi ja biosimilaarit. Ranta, Veli-Pekka; Honkakoski, Paavo / Biofarmasian perusteet. 2018. 2018
• Malinen, Melina M; Kauttonen, Antti; Beaudoin, James J; Sjöstedt, Noora; Honkakoski, Paavo; Brouwer, Kim LR. 2018. Novel in vitro method reveals drugs that inhibit solute transporter alpha/beta Molecular pharmaceutics 2019; 16 1: 238-246. 2018
• Biofarmasian tulevaisuuden näkymiä. Honkakoski; Paavo; Urtti; Arto / Biofarmasian perusteet. 2018. 2018
• Biofarmaseuttiset tutkimukset teollisuuden lääkekehityksessä. Honkakoski; Paavo; Korjamo; Timo; Ranta, Veli-Pekka / Biofarmasian perusteet. 2018. 2018
• Hytti M, Szabó D, Piippo N, Korhonen E, Honkakoski P, Kaarniranta K, Petrovski G, Kauppinen A. 2017. Two dietary polyphenols, fisetin and luteolin, reduce inflammation but augment DNA damage-induced toxicity in human RPE cell. JOURNAL OF NUTRITIONAL BIOCHEMISTRY 42: 37-42. 2017
• Ranta Veli-Pekka, Honkakoski Paavo, Ruponen Marika, Vellonen Kati-Sisko (toim.). 2017. Farmakokinetiikan perusteet. Farmasian opiskelijayhdistys Fortis ry. 2017
• Toivonen Sanna, Malinen Melina M, Küblbeck Jenni, Petsalo Aleksanteri, Urtti Arto, Honkakoski Paavo, Otonkoski Timo. 2016. Regulation of Human Pluripotent Stem Cell-Derived Hepatic Cell Phenotype by Three-Dimensional Hydrogel Models. TISSUE ENGINEERING 22 13-14: 971-984. 2016
• Küblbeck Jenni, Hakkarainen Jenni J, Petsalo Aleksanteri, Vellonen Kati-Sisko, Tolonen Ari, Reponen Petri, Forsberg Markus M, Honkakoski Paavo. 2016. Genetically Modified Caco-2 Cells With Improved Cytochrome P450 Metabolic Capacity. JOURNAL OF PHARMACEUTICAL SCIENCES 105 2: 941-949. 2016
• Kobayashi Kaoru, Hashimoto Mari, Honkakoski Paavo, Negishi Masahiko. 2015. Regulation of gene expression by CAR: an update. ARCHIVES OF TOXICOLOGY 89 7: 1045-1055. 2015
• Küblbeck Jenni, Anttila Teemu, Pulkkinen Juha T, Honkakoski Paavo. 2015. Improved assays for xenosensor activation based on reverse transfection. TOXICOLOGY IN VITRO 29 7: 1759-1765. 2015
• Küblbeck Jenni, Zancanella Vanessa, Prantner Victoria, Molnár Ferdinand, Squires E. James, Dacasto Mauro, Honkakoski Paavo, Giantin Mery. 2015. Characterization of ligand-dependent activation of bovine and pig constitutive androstane (CAR) and pregnane X receptors (PXR) with interspecies comparisons. XENOBIOTICA (LONDON) 46 (2016) 3: 200-210. 2015
• Molnár Ferdinand, Küblbeck Jenni, Jyrkkärinne Johanna, Prantner Viktória, Honkakoski Paavo. 2013. An update on the constitutive androstane receptor (CAR). Drug Metabolism and Drug Interactions 28 2: 79-93. 2013
• Pimkaew Prapapan, Küblbeck Jenni, Petsalo Aleksanteri, Jukka Jouni, Suksamrarn Apichart, Juvonen Risto, Auriola Seppo, Piyachaturawat Pawinee, Honkakoski Paavo. 2013. Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system. TOXICOLOGY IN VITRO 27 6: 2005-2012. 2013
• Abass Khaled, Lämsä Virpi, Reponen Petri, Küblbeck Jenni, Honkakoski Paavo, Mattila Sampo, Pelkonen Olavi, Hakkola Jukka. 2012. Characterization of human cytochrome P450 induction by pesticides TOXICOLOGY 294: 17-26. 2012
• Ma Liang, Barker Jeremy, Zhou Changchun, Li Wei, Zhang Jing, Lin Biaoyang, Foltz Gregory, Küblbeck Jenni, Honkakoski Paavo. 2012. Towards personalized medicine with a three-dimensional micro-scale perfusion-based two-chamber tissue model system BIOMATERIALS 33: 4353-4361. 2012
• Reinisalo Mika, Putula Jaana, Mannermaa Eliisa, Urtti Arto, Honkakoski Paavo. 2012. Regulation of the human tyrosinase gene in retinal pigment epithelium cells: the significance of transcription factor orthodenticle homeobox 2 and its polymorphic binding site MOLECULAR VISION [ONLINE: HTTP://WWW.MOLVIS.ORG/MOLVIS/] 18: 38-54. 2012
• Küblbeck Jenni, Jyrkkärinne Johanna, Molnár Ferdinand, Kuningas Tiina, Patel Jayendra, Windshügel Björn, Nevalainen Tapio, Laitinen Tuomo, Sippl Wolfgang, Poso Antti, Honkakoski Paavo. 2011. New in vitro tools to study human constitutive androstane receptor (CAR) biology: discovery and comparison of human CAR inverse agonists Molecular Pharmaceutics 8: 2424-2433. 2011
• Küblbeck Jenni, Laitinen Tuomo, Jyrkkärinne Johanna, Rousu Timo, Tolonen Ari, Abel Tobias, Kortelainen Tanja, Uusitalo Jouko, Korjamo Timo, Honkakoski Paavo, Molnár Ferdinand. 2011. Use of comprehensive screening methods to detect selective human CAR activators BIOCHEMICAL PHARMACOLOGY 82: 1994-2007. 2011
• Vellonen Kati-Sisko, Häkli Marika, Merezhinskaya Natalya, Tervo Timo, Honkakoski Paavo, Urtti Arto. 2010. Monocarboxylate transport in human corneal epithelium and cell lines. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 39: 241-247. 2010
• Vellonen K-S, Mannermaa E, Turner H, Häkli M, Wolosin M, Tervo T, Honkakoski P & Urtti A. 2010. Effluxing ABC transporters in human corneal epithelium JOURNAL OF PHARMACEUTICAL SCIENCES 99 2: 1087 - 1098. 2010
• Pulkkinen JT, Honkakoski P, Peräkylä M, Berczi I, Laatikainen R. 2008. Synthesis and evaluation of estrogen agonism of diaryl 4,5-dihydroisoxazoles, 3-hydroxyketones, 3-methoxyketones, and 1,3-diketones: A compound set forming a 4D molecular library. JOURNAL OF MEDICINAL CHEMISTRY 51: 3562-3571. 2008
• Korjamo T, Mönkkönen J, Uusitalo J, Turpeinen M, Pelkonen O, Honkakoski P. 2006. Metabolic and efflux properties of Caco-2 cells stably transfected with nuclear receptors. PHARMACEUTICAL RESEARCH 23 9: 1991-2001. 2006
• Poso A, Honkakoski P. 2006. Ligand recognition by drug-activated nuclear receptors PXR and CAR: structural, site-directed mutagenesis and molecular modeling studies MINI REVIEWS IN MEDICINAL CHEMISTRY 6: 937-943. 2006
• Jyrkkärinne J, Windshügel B, Mäkinen J, Ylisirniö M, Peräkylä M, Poso A, Sippl W, Honkakoski P. 2005. Amino acids important for ligand specificity of the human constitutive androstane receptor. JOURNAL OF BIOLOGICAL CHEMISTRY 280 7: 5960-5971. 2005
• Mäkinen J, Frank C, Jyrkkärinne J, Gynther J, Carlberg C, Honkakoski P. 2002. Modulation of mouse and human phenobarbital-responsive enhancer module by nuclear receptors. MOLECULAR PHARMACOLOGY 62 2: 366-378. 2002

Tiedostot

• Honkakoski_short_CV