PEKKA JARHO

Yhteystiedot

Julkaisut

• Seifert, T; Malo, M; Kokkola, T; Stéen, EJL; Meinander, K; Wallén, EAA; Jarho, EM; Luthman, K. 2019. A scaffold replacement approach towards new sirtuin 2 inhibitors Bioorganic and medicinal chemistry 2020; 28 2: 115231. 2019
• Turunen Elina, Korhonen Ossi, Lehto Vesa-Pekka, Kauppinen Ari, Ahtiainen Hanne, Järvinen Kristiina, Jarho Pekka. 2013. Effect of storage on the dissolution rate of a fast-dissolving perphenazine/β-cyclodextrin complex. JOURNAL OF PHARMACY AND PHARMACOLOGY 2014:66: 367-377. 2013
• Kaartama Ruut, Turunen Elina, Toljamo Kirsi, Kokki Hannu, Lehtonen Marko, Ranta Veli-Pekka, Savolainen Jouko, Järvinen Kristiina, Jarho Pekka. 2012. The effect of hydroxypropyl-beta-cyclodextrin and sucrose on the sublingual absorption of midazolam in rabbits EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 81: 178-183. 2012
• Kaartama Ruut, Jarho Pekka, Savolainen Jouko, Kokki Hannu, Lehtonen Marko. 2011. Determination of midazolam and 1-hydroxymidazolam from plasma by gas chromatography coupled to methane negative chemical ionization mass spectrometry after sublingual administration of midazolam. JOURNAL OF CHROMATOGRAPHY. B. ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 879: 1668 - 1676. 2011
• Larsen Kim L, Loftsson Thorsteinn, Mazzaglia Antonino, Jarho Pekka. 2011. Preface: First European cyclodextrin conference JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY 69 3-4: 295. 2011
• Turunen Elina, Mannila Janne, Laitinen Riikka, Riikonen Joakim, Lehto Vesa-Pekka, Järvinen Tomi, Ketolainen Jarkko, Järvinen Kristiina, Jarho Pekka. 2011. Fast-dissolving sublingual solid dispersion and cyclodextrin complex increase the absorption of perphenazine in rabbits. JOURNAL OF PHARMACY AND PHARMACOLOGY 63: 19 - 25. 2011
• Laitinen R, Lahtinen J, Silfsten P, Vartiainen E, Jarho P & Ketolainen J. 2010. An optical method for continuous monitoring of the dissolution rate of pharmaceutical powders. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 52: 181 - 189. 2010
• Mannila J, Järvinen K, Holappa J, Matilainen L, Auriola S, Jarho P. 2009. Cyclodextrins and chitosan derivatives in sublingual delivery of low solubility peptides: A study using cyclosporin A, alpha-cyclodextrin and quaternary chitosan N-betainate INTERNATIONAL JOURNAL OF PHARMACEUTICS 381: 19-24. 2009
• Turunen E, Lehtonen M, Järvinen T, Jarho P. 2008. Development and validation of a gas chromatographic-mass spectrometric method for quantitative determination of perphenazine in rabbit plasma after sublingual administration JOURNAL OF CHROMATOGRAPHY. B. ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 872: 51-57. 2008
• Toropainen T, Jarho P, Lehtonen M, Keski-Rahkonen P, Raatikainen H, Järvinen T. 2008. Quantitative analysis of natural cyclodextrins by high-performance liquid chromatography with pulsed amperometric detection: Application to cell permeation study. JOURNAL OF CHROMATOGRAPHY. B. ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 867: 90-98. 2008
• Matilainen L, Toropainen T, Vihola H, Hirvonen J, Järvinen T, Jarho P, Järvinen K. 2008. In vitro toxicity and permeation of cyclodextrins in Calu-3 cells. JOURNAL OF CONTROLLED RELEASE 126: 10-16. 2008
• Matilainen L, Lambertsen Larsen K, Wimmer R, Keski-Rahkonen P, Auriola S, Järvinen T, Jarho P. 2008. The effect of cyclodextrins on chemical and physical stability of glucagon and characterization of glucagon/gamma-CD inclusion complexes JOURNAL OF PHARMACEUTICAL SCIENCES 97 7: 2720-2729. 2008
• Lääkepäivät - Lääkkeitä myös terveille?. 25.-26.4.2008 Kuopio. Jarho P. 2008 2008
• Toropainen T, Heikkilä T, Leppänen J, Matilainen L, Velaga S, Jarho P, Carlfors J, Lehto V-P, Järvinen T, Järvinen K. 2007. Crystal structure changes of gamma-cyclodextrin after the SEDS process in supercritical carbon dioxide affect the dissolution rate of complexed budesonide. PHARMACEUTICAL RESEARCH 24 6: 1058-1066. 2007
• Järvinen T, Mannila J, Jarho P. 2006. Novel methylated cyclodextrin complexes. NZ535153. Uusi-Seelanti. 2006
• Mannila J, Järvinen T, Järvinen K, Jarho P. 2006. Precipitation complexation method produces cannabidiol/beta-cyclodextrin inclusion complex suitable for sublingual administration of cannabidiol JOURNAL OF PHARMACEUTICAL SCIENCES 96: 312-319. 2006
• Mannila J, Järvinen T, Järvinen K, Tervonen J, Jarho P. 2006. Sublingual administration of Delta9 -tetrahydrocannabinol/ß-cyclodextrin complex increases the bioavailability of Delta9 -tetrahydrocannabinol in rabbits. LIFE SCIENCES 78: 1911-1914. 2006
• Matilainen L, Järvinen K, Toropainen T, Näsi E, Auriola S, Järvinen T, Jarho P. 2006. In vitro evaluation of the effect of cyclodextrin complexation on pulmonary deposition of a peptide, cyclosporin A. INTERNATIONAL JOURNAL OF PHARMACEUTICS 318: 41-48. 2006
• Toropainen T, Velaga S, Heikkilä T, Matilainen L, Jarho P, Carlfors J, Lehto V-P, Järvinen T, Järvinen K. 2006. Preparation of budesonide/gamma-cyclodextrin complexes in supercritical fluids with a novel SEDS method. JOURNAL OF PHARMACEUTICAL SCIENCES 95 10: 2235-2245. 2006
• Järvinen T, Jarho P, Unkila M, Hiilovaara-Teijo M. 2005. Lignaanikomplekseja. FI 114917 B. Suomi. 2005
• Loftsson T, Jarho P, Másson M, Järvinen T. 2005. Cyclodextrins in drug delivery. EXPERT OPINION ON DRUG DELIVERY 2 2: 335-351. 2005
• Mannila J, Järvinen T, Järvinen K, Tarvainen M, Jarho P. 2005. Effects of RM-beta-CD on sublingual bioavailability of Delta9-tetrahydrocannabinol in rabbits EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 26: 71-77. 2005
• Mannila J, Lehtonen M, Järvinen T, Jarho P. 2004. Determination of delta9 -tetrahydrocannabinol from rabbit plasma by gas chromatography-mass spectrometry using two ionization techniques JOURNAL OF CHROMATOGRAPHY. B. ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 810: 283-290. 2004
• Kinnarinen T, Järvinen K, Jarho P, Vihola H, Hirvonen J, Järvinen T. 2004. Cyclodextrins in pulmonary drug delivery: in vitro toxicity of cyclodextrins in calu-3 cells, Respiratory Drug Delivery IX. Biological, Pharmaceutical, Clinical, and Regultory Issues Relating to Optimized Drug Delivery by Aerosol.Davis Healthcare International Publishing, LLC. 773-776. 2004
• Jarho P, Mannila J, Järvinen T. 2004. Uudet luonnon syklodekstriinin kompleksit. FI 113340 B. Suomi. 2004
• Järvinen T, Mannila J, Jarho P. 2003. Uudet metyloidut syklodekstriininkompleksit. 111733. Suomi. 2003
• Kinnarinen T, Jarho P, Järvinen K, Järvinen T. 2003. Pulmonary deposition of a budesonide/gamma-cyclodextrin complex in vitro. JOURNAL OF CONTROLLED RELEASE 90: 197-205. 2003
• Kinnarinen T, Jarho P, Järvinen K, Järvinen T. 2002. The in vitro pulmonary deposition of a budesonide/gamma-cyclodextrin inclusion complex. Teoksessa: (toim.), Proceedings of the 11th International Cyclodextrin Symposium.Kluwer Academic Publishers. Journal of Inclusion Phenomena and Macrocyclic Chemistry. ss. 97-100. 2002
• Jarho P, Vander Velde D, Stella VJ. 2001. The effect of cyclodextrin and pH on cyclodextrincatalyzed deacetylation of spironolactone: Szejtli J, Cyclodextrins: From Basic Research to Market. 10th International Cyclodextrin Symposium CD2000.Mira Digital Publishing. 500-505. 2001
• Suihko E, Korhonen O, Järvinen T, Ketolainen J, Jarho P, Laine E, Paronen P. 2001. Complexation with tolbutamide modifies the physicochemical and tableting properties of hydroxypropyl-beta-cyclodextrin. INTERNATIONAL JOURNAL OF PHARMACEUTICS 215: 137-145. 2001
• Jarho P, Järvinen T. 2000. Syklodekstriinit - perustutkimuksesta lääkkeisiin TABU 5: 12-14. 2000
• Jarho P, Vander Velde D, Stella VJ. 2000. Cyclodextrin-catalyzed deacetylation of spironolactone is pH and cyclodextrin dependent. JOURNAL OF PHARMACEUTICAL SCIENCES 89 2: 241-249. 2000
• Savolainen J, Forsberg M, Taipale H, Männistö PT, Järvinen K, Gynther J, Jarho P, Järvinen T. 2000. Effects of aqueous solubility and dissolution characteristics on oral bioavailability of entacapone. DRUG DEVELOPMENT RESEARCH 49: 238-244. 2000
• Savolainen J, Järvinen K, Taipale H, Jarho P, Loftsson T, Järvinen T. 1999. Coadministration of a water-soluble polymer increases the usefulness of cyclodextrins in solid oral dosage forms. Teoksessa: Torres Labandeira JJ, Vila-Jato JL (toim.), Proceedings of the Ninth International Symposium on Cyclodextrins.Kluwer Academic. ss. 261-264. 1999
• Savolainen J, Järvinen K, Taipale H, Jarho P, Loftsson T, Järvinen T. 1998. Co-administration of a water-soluble polymer increases the usefulness of cyclodextrins in solid oral dosage forms. PHARMACEUTICAL RESEARCH 15 11: 1696-1701. 1998
• Jarho P. 1998. Syklodekstriinit silmätippaformulaatiossa. DOSIS : FARMASEUTTINEN AIKAKAUSKIRJA 14 2: 82-86. 1998
• Jarho P, Pate DW, Brenneisen R, Järvinen T. 1998. Hydroxypropyl-beta-cyclodextrin and its combination with hydroxypropyl-methylcellulose increases aqueous solubility of delta9-tetrahydrocannabinol. LIFE SCIENCES 63 26: 381-384. 1998
• Jarho P, Järvinen K, Urtti A, Stella VJ, Järvinen T. 1997. The use of cyclodextrins in ophthalmic formulations of dipivefrin. INTERNATIONAL JOURNAL OF PHARMACEUTICS 153: 225-233. 1997
• Jarho P. 1997. Cyclodextrins in Eyedrop Formulations. Studies with Pilocarpine Prodrugs, Anandamide and Dipivefrine. Kuopion yliopiston julkaisuja A. Farmaseuttiset tieteet. 1997
• Pate DW, Järvinen K, Urtti A, Jarho P, Mahadevan V, Järvinen T. 1997. Effects of Topical alpha-substituted anandamides on intraocular pressure in normotensive rabbits. PHARMACEUTICAL RESEARCH 14 12: 1738-1743. 1997
• Saarinen-Savolainen P, Urtti A, Jarho P, Järvinen T. 1997. Beta-cyclodextrin derivatives (2-HP-beta-CD, SBE4-beta-CD) decrease the amphiphilicity and membrane perturbing effects of pilocarpine prodrugs. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 5: 89-96. 1997
• Jarho P, Järvinen K, Urtti A, Stella VJ, Järvinen T. 1996. Modified ß-cyclodextrin (SBE7-ß-CyD) with viscous vehicle improves the ocular delivery and tolerability of pilocarpine prodrug in rabbits. JOURNAL OF PHARMACY AND PHARMACOLOGY 48: 263-269. 1996
• Jarho P, Järvinen K, Urtti A, Stella VJ, Järvinen T. 1996. The effect of SBE7-ß-CD with viscous vehicle on ocular delivery of pilocarpine prodrug in rabbits: Szejtli J, Szente L, Proceedings of the Eighth International Symposium on Cyclodextrons.Kluwer. 399-402. 1996
• Jarho P, Urtti A, Järvinen K, Pate DW, Järvinen T. 1996. Hydroxypropyl-ß-cyclodextrin increases aqueous solubility and stability of anandamide. LIFE SCIENCES 58 10: 181-185. 1996
• Jarho P, Urtti A, Pate DW, Suhonen P, Järvinen T. 1996. Increase in aqueous solubility, stability and in vitro corneal permeability of anandamide by hydroxypropyl-ß-cyclodextrin. INTERNATIONAL JOURNAL OF PHARMACEUTICS 137: 209-216. 1996
• Jarho P, Urtti A, Pate DW, Suhonen P, Järvinen T. 1996. The effects of HP-ß-CD on aqueous solubility, stability and in vitro corneal penetration of anandamide. Teoksessa: Szejtli J, Szente L (toim.), Proceedings of the Eight International Symposium on Cyclodextrons.Kluwer. ss. 395-398. 1996
• Pate DW, Järvinen K, Urtti A, Jarho P, Fich M, Mahadevan V, Järvinen T. 1996. Effects of topical anandamides on intraocular pressure in normotensive rabbits. LIFE SCIENCES 58 21: 1849-1860. 1996
• Jarho P, Urtti A, Järvinen T. 1995. Hydroxypropyl-ß-cyclodextrin increases the aqueous solubility and stability of pilocarpine prodrugs. PHARMACEUTICAL RESEARCH 12 9: 1371-1375. 1995
• Pate DW, Järvinen K, Urtti A, Jarho P, Järvinen T. 1995. Ophthalmic arachidonylethanolamide decreases intraocular pressure in normotensive rabbits. CURRENT EYE RESEARCH 14: 791-797. 1995