Reijo Sironen

Launonen, Kaisa-Mari; Paakinaho, Ville; Sigismondo, Gianluca; Malinen, Marjo; Sironen, Reijo; Hartikainen, Jaana M; Laakso, Hanna; Visakorpi, Tapio; Krijgsveld, Jeroen; Niskanen, Einari A; Palvimo, Jorma J. 2021. Chromatin-directed proteomics-identified network of endogenous androgen receptor in prostate cancer cells Oncogene 40 27: 4567-4579. 2021

Salmi, Satu; Lin, Anton; Hirschovits-Gerz, Benjamin; Valkonen, Mari; Aaltonen, Niina; Sironen, Reijo; Siiskonen, Hanna; Pasonen-Seppänen, Sanna. 2021. The role of FoxP3+ regulatory T cells and IDO+ immune and tumor cells in malignant melanoma - an immunohistochemical study Bmc cancer 21 1: 641. 2021

Jokelainen, Otto; Pasonen-Seppänen, Sanna; Tammi, Markku; Mannermaa, Arto; Aaltomaa, Sirpa; Sironen, Reijo; Nykopp, Timo K. 2020. Cellular hyaluronan is associated with a poor prognosis in renal cell carcinoma Urologic oncology: seminars and original investigations 38 8: 686.e11-686.e22. 2020

Kinnunen, Anna-Reetta; Sironen, Reijo; Sipola, Petri. 2020. Magnetic resonance imaging characteristics in patients with histopathologically proven fibrous dysplasia - a systematic review Skeletal radiology 49: 837-845. 2020

Kujala, J; Hartikainen, JM; Tengström, M; Sironen, R; Kosma, VM; Mannermaa, A. 2020. High Mutation Burden of Circulating Cell-Free DNA in Early-Stage Breast Cancer Patients Is Associated With a Poor Relapse-Free Survival Cancer medicine 9 16: 5922-5931. 2020

Härkönen, K; Oikari, S; Kyykallio, H; Capra, J; Hakkola, S; Ketola, K; Thanigai Arasu, U; Daaboul, G; Malloy, A; Oliveira, C; Jokelainen, O; Sironen, R; Hartikainen, JM; Rilla, K. 2019. CD44s Assembles Hyaluronan Coat on Filopodia and Extracellular Vesicles and Induces Tumorigenicity of MKN74 Gastric Carcinoma Cells Cells 8 3: 276. 2019

Salmi, Satu; Siiskonen, Hanna; Sironen, Reijo; Tyynelä-Korhonen, Kristiina; Hirschovits-Gerz, Benjamin; Valkonen, Mari; Auvinen, Päivi; Pasonen-Seppänen, Sanna. 2018. The number and localization of CD68+ and CD163+ macrophages in different stages of cutaneous melanoma Melanoma research 29 3: 237-247. 2018

Lahtinen O, Eloranta M, Anttila M, Kärkkäinen H, Sironen R, Vanninen R, Rautiainen S. 2017. Preoperative sentinel lymph node localization in vulvar cancer: preliminary experience with inguinal intradermal contrast-enhanced ultrasound European radiology 2018; 28 5: 2089-2095. 2017

Kauhanen Petteri S, Suoranta Sanna, Oksala Emma, Karhapää Pauli, Sironen Reijo, Manninen Hannu, Rautiainen Suvi. 2017. Munuaisbiopsioiden komplikaatiot Kuopion yliopistollisessa sairaalassa vuosina 2013-2016. DUODECIM 133 17: 1593-1601. 2017

Jauhonen HM, Laihia J, Oksala O, Viiri J, Sironen R, Alajuuma P, Kaarniranta K, Leino L. 2017. Topical cis-urocanic acid prevents ocular surface irritation in both IgE -independent and -mediated rat model. GRAEFE'S ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY 255 12: 2357-2362. 2017

Arponen Otso, Masarwah Amro, Sutela Anna, Taina Mikko, Könönen Mervi, Sironen Reijo, Hakumäki Juhana, Vanninen Ritva, Sudah Mazen. 2016. Incidentally detected enhancing lesions found in breast MRI: analysis of apparent diffusion coefficient and T2 signal intensity significantly improves specificity. EUROPEAN RADIOLOGY 26 12: 4361-4370. 2016

Kivinen Niko, Felszeghy Szabolcs, Kinnunen Aino I, Setälä Niko, Aikio Mari, Kinnunen Kati, Sironen Reijo, Pihlajaniemi Taina, Kauppinen Anu, Kaarniranta Kai. 2016. Absence of collagen XVIII in mice causes age-related insufficiency in retinal pigment epithelium proteostasis. BIOGERONTOLOGY 17 4: 749-761. 2016

Poukka M, Bykachev A, Siiskonen H, Tyynelä-Korhonen K, Auvinen P, Pasonen-Seppänen S, Sironen R. 2016. Decreased expression of hyaluronan synthase 1 and 2 associates with poor prognosis in cutaneous melanoma. BMC CANCER [ONLINE: HTTP://WWW.BIOMEDCENTRAL.COM/BMCCANCER/] 16 313: 1-11. 2016

Tuuminen T, Österblad M, Hämäläinen S, Sironen R. 2016. Relapsing sepsis episodes of Escherichia coli with CTX-M ESBL or derepressed ampC genes in a patient with chronic autoimmune pancreatitis complicated by IgG4 hypergammaglobulinaemia. New Microbes and New Infections 9: 50-53. 2016

Törrönen Kari, Soini Ylermi, Pääkkö Paavo, Parkkinen Jyrki, Sironen Reijo, Rilla Kirsi. 2016. Mesotheliomas show higher hyaluronan positivity around tumor cells than metastatic pulmonary adenocarcinomas. HISTOLOGY AND HISTOPATHOLOGY 31 10: 1113-1122. 2016

Rautiainen Suvi, Sudah Mazen, Joukainen Sarianna, Sironen Reijo, Vanninen Ritva, Sutela Anna. 2015. Contrast-enhanced ultrasound -guided axillary lymph node core biopsy: Diagnostic accuracy in preoperative staging of invasive breast cancer. EUROPEAN JOURNAL OF RADIOLOGY 84 11: 2130-2136. 2015

Sung Hyuna, Garcia-Closas Montserrat, Chang-Claude Jenny, Blows Fiona M, Ali H Raza, Figueroa Jonine, Nevanlinna Heli, Fagerholm Rainer, Heikkilä Päivi, Blomqvist Carl, Giles Graham G, Milne Roger L, Southey Melissa C, McLean Catriona, Mannermaa Arto, Kosma Veli-Matti, Kataja Vesa, Sironen Reijo, Couch Fergus J, Olson Janet E et al. 2015. Heterogeneity of luminal breast cancer characterised by immunohistochemical expression of basal markers. BRITISH JOURNAL OF CANCER 114 (02 February 2016): 298-304. 2015

Siiskonen Hanna, Poukka Mari, Bykachev Andrey, Tyynelä-Korhonen Kristiina, Sironen Reijo, Pasonen-Seppänen Sanna, Harvima Ilkka T. 2015. Low numbers of tryptase+ and chymase+ mast cells associated with reduced survival and advanced tumor stage in melanoma. MELANOMA RESEARCH [epub ahead of print 27 July 2015]: -. 2015

Nykopp Timo K, Pasonen-Seppänen Sanna, Tammi Markku I, Tammi Raija H, Kosma Veli-Matti, Anttila Maarit, Sironen Reijo. 2015. Decreased hyaluronidase 1 expression is associated with early disease recurrence in human endometrial cancer GYNECOLOGIC ONCOLOGY 137 1: 152-159. 2015

Rautiainen Suvi, Könönen Mervi, Sironen Reijo, Masarwah Amro, Sudah Mazen, Hakumäki Juhana, Vanninen Ritva, Sutela Anna. 2015. Preoperative Axillary Staging with 3.0-T Breast MRI: Clinical Value of Diffusion Imaging and Apparent Diffusion Coefficient. PLOS ONE [ONLINE] 10 3: e0122516. 2015

Jouppila-Mättö Anna, Mannermaa Arto, Sironen Reijo, Kosma Veli-Matti, Soini Ylermi, Pukkila Matti. 2015. SIP1 predicts progression and poor prognosis in pharyngeal squamous cell carcinoma. HISTOLOGY AND HISTOPATHOLOGY 30: 569-579. 2015

Arponen Otso, Sudah Mazen, Masarwah Amro, Taina Mikko, Rautiainen Suvi, Könönen Mervi, Sironen Reijo, Kosma Veli-Matti, Sutela Anna, Hakumäki Juhana, Vanninen Ritva. 2015. Diffusion-Weighted Imaging in 3.0 Tesla Breast MRI: Diagnostic Performance and Tumor Characterization Using Small Subregions vs. Whole Tumor Regions of Interest. PLOS ONE [ONLINE] 10 10: e0138702. 2015

Auvinen Päivi, Rilla Kirsi, Tumelius Ritva, Tammi Markku, Sironen Reijo, Soini Ylermi, Kosma Veli-Matti, Mannermaa Arto, Viikari Jukka, Tammi Raija. 2014. Hyaluronan synthases (HAS1-3) in stromal and malignant cells correlate with breast cancer grade and predict patient survival. BREAST CANCER RESEARCH AND TREATMENT 143 2: 277-286. 2014

Pietilä M, Dhungana H, Uimari A, Sironen R, Alhonen L. 2013. Systemic overexpression of antizyme 1 in mouse reduces ornithine decarboxylase activity without major changes in tissue polyamine homeostasis. TRANSGENIC RESEARCH [Epub ahead of print]: -. 2013

Pirnes-Karhu S, Mäntymaa P, Sironen R, Mäkinen PI, Wojciechowski S, Juutinen S, Koistinaho J, Hörkkö S, Jantunen E, Alhonen L, Uimari A. 2013. Enhanced polyamine catabolism disturbs hematopoietic lineage commitment and leads to a myeloproliferative disease in mice overexpressing spermidine/spermine N 1-acetyltransferase. AMINO ACIDS 2013 Jul 9. [Epub ahead of print]: -. 2013

Rautiainen S, Masarwah A, Sudah M, Sutela A, Pelkonen O, Joukainen S, Sironen R, Kärjä V, Vanninen R. 2013. Axillary Lymph Node Biopsy in Newly Diagnosed Invasive Breast Cancer: Comparative Accuracy of Fine-Needle Aspiration Biopsy versus Core-Needle Biopsy. RADIOLOGY 269 1: 54-60. 2013

Siiskonen H, Poukka M, Tyynelä-Korhonen K, Sironen R, Pasonen-Seppänen S. 2013. Inverse expression of hyaluronidase 2 and hyaluronan synthases 1-3 is associated with reduced hyaluronan content in malignant cutaneous melanoma. BMC CANCER [ONLINE: HTTP://WWW.BIOMEDCENTRAL.COM/BMCCANCER/] 13 181: e1-12. 2013

Tuhkanen H, Hartikainen JM, Soini Y, Velasco G, Sironen R, Nykopp TK, Kataja V, Eskelinen M, Kosma VM, Mannermaa A.. 2013. Matriptase-2 gene (TMPRSS6) variants associate with breast cancer survival, and reduced expression is related to triple-negative breast cancer INTERNATIONAL JOURNAL OF CANCER 133 10: 2334-2340. 2013

Viiri J, Amadio M, Marchesi N, Hyttinen JM, Kivinen N, Sironen R, Rilla K, Akhtar S, Provenzani A, D'Agostino VG, Govoni S, Pascale A, Agostini H, Petrovski G, Salminen A, Kaarniranta K. 2013. Autophagy Activation Clears ELAVL1/HuR-Mediated Accumulation of SQSTM1/p62 during Proteasomal Inhibition in Human Retinal Pigment Epithelial Cells. PLOS ONE [ONLINE] 8 7: e6963, 16 pages. 2013

Auvinen P, Tammi R, Kosma VM, Sironen R, Soini Y, Mannermaa A, Tumelius R, Uljas E, Tammi M. 2012. Increased hyaluronan content and stromal cell CD44 associate with HER2 positivity and poor prognosis in human breast cancer. INTERNATIONAL JOURNAL OF CANCER 132 3: 531-539. 2012

Pirnes-Karhu S, Sironen R, Alhonen L, Uimari A. 2012. Lipopolysaccharide-induced anti-inflammatory acute phase response is enhanced in spermidine/spermine N (1)-acetyltransferase (SSAT) overexpressing mice.. AMINO ACIDS 2012 Feb;42(2-3): 473-8. 2012

Uimari A, Merentie M, Sironen R, Pirnes-Karhu S, Peräniemi S, Alhonen L.. 2012. Overexpression of spermidine/spermine N1-acetyltransferase or treatment with N1-N11-diethylnorspermine attenuates the severity of zinc-induced pancreatitis in mouse. AMINO ACIDS 2012 Feb;42(2-3): 461-71. 2012

Soini Ylermi, Tuhkanen Hanna, Sironen Reijo, Virtanen Ismo, Kataja Vesa, Auvinen Päivi, Mannermaa Arto, Kosma Veli-Matti. 2011. Transcription factors zeb1, twist and snai1 in breast carcinoma BMC CANCER [ONLINE: HTTP://WWW.BIOMEDCENTRAL.COM/BMCCANCER/] 11 11: -. 2011

Yang Xiaohong R, Chang-Claude Jenny, Goode Ellen L, Couch Fergus J, Nevanlinna Heli, Milne Roger L, Gaudet Mia, Schmidt Marjanka K, Broeks Annegien, Cox Angela, Fasching Peter A, Hein Rebecca, Spurdle Amanda B, Blows Fiona, Driver Kristy, Flesch-Janys Dieter, Heinz Judith, Sinn Peter, Vrieling Alina, Heikkinen Tuomas et al. 2011. Associations of Breast Cancer Risk Factors With Tumor Subtypes: A Pooled Analysis From the Breast Cancer Association Consortium Studies. JOURNAL OF THE NATIONAL CANCER INSTITUTE 103 3: 250-263. 2011

Jouppila-Mättö A, Tuhkanen H, Soini Y, Pukkila M, Närkiö-Mäkelä M, Sironen R, Virtanen I, Mannermaa A, Kosma V-M. 2011. Transcription of factor snail1 expression and poor survival in pharyngeal squamous cell carcinoma. HISTOLOGY AND HISTOPATHOLOGY 26: 443-449. 2011

Sironen RK, Tammi M, Tammi R, Auvinen PK, Anttila M & Kosma VM. 2011. Hyaluronan in human malignancies. EXPERIMENTAL CELL RESEARCH 317 4: 383-391. 2011

Juoppila-Mättö Anna, Närkiö-Mäkelä Mervi, Soini Ylermi, Pukkila Matti, Sironen Reijo, Tuhkanen Hanna, Mannermaa Arto, Kosma Veli-Matti. 2011. Twist and snai1 expression in pharyngeal squamous cell carcinoma stroma is related to cancer progression BMC CANCER [ONLINE: HTTP://WWW.BIOMEDCENTRAL.COM/BMCCANCER/] 11: 350. 2011

Kauppinen J, Kosma V-M, Soini Y, Sironen R, Nissinen M, Nykopp T, Kärjä V, Eskelinen M, Kataja V, Mannermaa A. 2010. ST14 gene variant and decreased matriptase protein expression predict poor breast cancer survival CANCER EPIDEMIOLOGY, BIOMARKERS AND PREVENTION 19 9: 2133-2142. 2010

Nykopp TK, Rilla K, Tammi MI, Tammi RH, Sironen R, Hämäläinen K, Kosma V-M, Heinonen S & Anttila M. 2010. Hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma BMC CANCER 10: 512. 2010

Sironen RK, Seppä A, Kosma VM. 2010. Churg-Strauss syndrome manifested by appendicitis, cholecystitis and superficial micronodular liver lesions-an unusual clinicopathological presentation. JOURNAL OF CLINICAL PATHOLOGY 63 9: 848-850. 2010

Nykopp TK, Rilla K, Sironen R, Tammi MI, Tammi RH, Hämäläinen K, Heikkinen A-M, Komulainen M, Kosma V-M, Anttila M. 2009. Expression of hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in serous ovarian carcinomas: inverse correlation between HYALI and hyaluronan content. BMC CANCER [ONLINE: HTTP://WWW.BIOMEDCENTRAL.COM/BMCCANCER/] 9 143: [9 p.]. 2009

Tuhkanen H, Soini Y, Kosma V-M, Anttila M, Sironen R, Hämäläinen K, Kukkonen L, Virtanen I, Mannermaa A. 2009. Nuclear expression of Snail1 in borderline and malignant epithelial ovarian tumours is associated with tumour progression. BMC CANCER [ONLINE: HTTP://WWW.BIOMEDCENTRAL.COM/BMCCANCER/] 9 289. 2009

Kosunen A, Pirinen R, Ropponen K, Pukkila M, Kellokoski J, Virtaniemi J, Sironen R, Juhola M, Kumpulainen E, Johansson R, Nuutinen J, Kosma V-M. 2007. CD44 expression and its relationship with MMP-9, clinicopathological factors and survival in oral squamous cell carcinoma ORAL ONCOLOGY 43: 51-59. 2007

Sillanpää S, Anttila M, Suhonen K, Hämäläinen K, Turpeenniemi-Hujanen T, Puistola U, Tammi M, Sironen R, Saarikoski S, Kosma VM. 2007. Prognostic significance of extracellular matrix metalloproteinase inducer and matrix metalloproteinase 2 in epithelial ovarian cancer. TUMOUR BIOLOGY 28 5: 280-289. 2007

Sillanpää S, Anttila M, Voutilainen K, Ropponen K, Turpeenniemi-Hujanen T, Puistola U, Tammi R, Tammi M, Sironen R, Saarikoski S, Kosma V-M. 2007. Prognostic significance of matrix metalloproteinase-9 (MMP-9) in epithelial ovarian cancer. GYNECOLOGIC ONCOLOGY 104: 296-303. 2007

Sillanpää SM, Anttila MA, Voutilainen KA, Ropponen KM, Sironen RK, Saarikoski SV, Kosma V-M. 2006. Prognostic significance of matrix metalloproteinase-7 in epithelial ovarian cancer and its relation to beta-catenin expression. INTERNATIONAL JOURNAL OF CANCER 119: 1792-1799. 2006

Elo MA, Karjalainen HM, Sironen RK, Valmu L, Redpath NT, Browne GJ, Kalkkinen N, Helminen HJ, Lammi MJ. 2005. High hydrostatic pressure inhibits the biosynthesis of eukaryotic elongation factor-2 JOURNAL OF CELLULAR BIOCHEMISTRY 94: 497-507. 2005

Kaarniranta K, Ryhänen T, Sironen RK, Suuronen T, Elo MA, Karjalainen HM, Lammi MJ, Teräsvirta M, Uusitalo H, Salminen A. 2005. Geldanamycin activates Hsp70 response and attenuates okadaic acid-induced cytotoxicity in human retinal pigment epithelial cells MOLECULAR BRAIN RESEARCH 137: 126-131. 2005

Sironen RK, Karjalainen HM, Törrönen KJ, Elo MA, Hyttinen MM, Helminen HJ, Lammi MJ. 2004. Reticulon 4 in chondrocytic cells: barosensitivity and intracellular localization. INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND CELL BIOLOGY 36: 1521-1531. 2004

Lammi MJ, Elo MA, Sironen RK, Karjalainen HM, Kaarniranta K, Helminen HJ. 2004. Hydrostatic pressure-induced changes in cellular protein syntheisis BIORHEOLOGY 41: 309-313. 2004

Kopakkala-Tani M, Elo MA, Sironen RK, Helminen HJ, Lammi MJ. 2004. High hydrostatic pressure induces erk and P13 kinase phosphorylation in human HCS-2/8 chondrosarcoma cells. CELLULAR AND MOLECULAR BIOLOGY [ONLINE: HTTP://WWW.CELLMOLBIOL.COM/] 50 4: 485-490. 2004

Elo MA, Sironen RK, Karjalainen HM, Kaarniranta K, Helminen HJ, Lammi MJ. 2003. Specific induction of heat shock protein 90 beta by high hydrostatic pressure BIORHEOLOGY 40 1-3: 141-146. 2003

Kaarniranta K, Elo MA, Sironen RK, Karjalainen HM, Helminen HJ, Lammi MJ. 2003. Stress responses of mammalian cells to high hydrostatic pressure. BIORHEOLOGY 40 1-3: 87-92. 2003

Karjalainen HM, Sironen RK, Elo MA, Kaarniranta K, Takigawa M, Helminen HJ, Lammi MJ. 2003. Gene expression profiles in chondrosarcoma cells subjected to cyclic stretching and hydrostatic pressure. A cDNA array study BIORHEOLOGY 40 1-3: 93-100. 2003

Rilla K, Lammi M, Sironen R, Hascall VC, Midura R, Tammi M, Tammi R. 2002. Hyaluronan synthase 2 (HAS2) regulates migration of epidermal keratinocytes: Kennedy JF, Phillips GO, Williams PA, Hascall VC, Hyaluronan. Chemical, Biochemical and Biological Aspects.Woodhead. 557-560. 2002

Rilla K, Lammi MJ, Sironen R, Törrönen K, Luukkonen M, Hascall VC, Midura RJ, Hyttinen M, Pelkonen J, Tammi M, Tammi R. 2002. Changed lamellipodial extension, adhesion plaques and migration in epidermal keratinocytes containing constitutively expressed sense and antisense hyaluronan synthase 2 (Has2) genes JOURNAL OF CELL SCIENCE 115: 3633-3643. 2002

Sironen RK, Karjalainen HM, Elo MA, Kaarniranta K, Törrönen K, Takigawa M, Helminen HJ, Lammi MJ. 2002. cDNA array reveals mechanosensitive genes in chondrocytic cells under hydrostatic pressure. BIOCHIMICA ET BIOPHYSICA ACTA - MOLECULAR CELL RESEARCH 1591: 45-54. 2002

Sironen RK, Karjalainen HM, Törrönen K, Elo MA, Kaarniranta K, Takigawa M, Helminen HJ, Lammi MJ. 2002. High pressure effects on cellular expression profile and mRNA stability. A cDNA array analysis. BIORHEOLOGY 39 1,2: 111-117. 2002

Tammi MI, Pienimäki J-P, Rilla K, Fülöp C, Lammi MJ, Sironen R, Midura R, Hascall VC, Luukkonen M, Törrönen K, Lehto T, Tammi R. 2002. EGF regulates HAS2 expression, controls epidermal thickness and stimulates keratinocyte migration: Kennedy JF, Phillips GO, Williams PA, Hascall VC, Hyaluronan. Chemical, Biochemical and Biological Aspects..Woodhead. 561-570. 2002

Lammi MJ, Sironen RK, Elo MA, Oksala N, Kaarniranta K, Karjalainen HM, Helminen HJ. 2001. Responses of mammalian cells to mechanical forces: Pandalai SG, Recent Research Developments in Biophysics and Biochemistry.Research Signpost. 77-98. 2001

Lapveteläinen T, Hyttinen M, Lindblom J, Långsjö TK, Sironen R, Li S-W, Arita M, Prockop DJ, Puustjärvi K, Helminen HJ. 2001. More knee joint osteoarthritis (OA) in mice after inactivation of one allele of type II procollagen gene but less OA after lifelong voluntary wheel running excercise OSTEOARTHRITIS AND CARTILAGE 9 2: 152-160. 2001

Pienimäki J-P, Rilla K, Csaba F, Sironen RK, Karvinen S, Pasonen S, Lammi MJ, Tammi R, Hascall VC, Tammi MI. 2001. Epidermal growth factor activates hyaluronan synthase 2 in epidermal keratinocytes and increases pericellular and intracellular hyaluronan. JOURNAL OF BIOLOGICAL CHEMISTRY 276 23: 20428-20435. 2001

Elo MA, Sironen RK, Kaarniranta K, Auriola S, Helminen HJ, Lammi MJ. 2000. Differential regulation of stress proteins by high hydrostatic pressure, heat shock, and unbalanced calcium homeostasis in chondrocytis cells. JOURNAL OF CELLULAR BIOCHEMISTRY 79: 610-619. 2000

Sironen R, Elo M, Kaarniranta K, Helminen HJ, Lammi MJ. 2000. Transcriptional activation in chondrocytes submitted to hydrostatic pressure BIORHEOLOGY 37: 85-93. 2000

Kaarniranta K, Elo M, Sironen R, Lammi MJ, Goldring MB, Eriksson JE, Sistonen L, Helminen HJ. 1998. Hsp70 accumulation in chondrocytic cells exposed to high continuous hydrostatic pressure coincides with mRNA stabilization rather than transcriptional activation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 95: 2319-2324. 1998

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