RIIKKA LAITINEN

Yliopistotutkija

Yhteystiedot

Organisaatio

Terveystieteiden tiedekunta, Farmasian laitos

Sähköposti

riikka.laitinen@uef.fi

Puhelin

050 569 5303

Tutkimusryhmät

Julkaisut

Viidik, Laura; Vesala, Jemina; Laitinen, Riikka; Korhonen, Ossi; Ketolainen, Jarkko; Aruväli, Jaan; Kirsimäe, Kalle; Kogermann, Karin; Heinämäki, Jyrki; Laidmäe, Ivo; Ervasti, Tuomas. 2021. Preparation and characterization of hot-melt extruded polycaprolactone-based filaments intended for 3D-printing of tablets European journal of pharmaceutical sciences In Press Journal Pre-proof 29.10.20: 1-27. 2021
Ruponen, Marika; Kettunen, Konsta; Santiago Pires, Monica; Laitinen, Riikka. 2021. Co-Amorphous Formulations of Furosemide with Arginine and P-Glycoprotein Inhibitor Drugs Pharmaceutics 13 2: 171. 2021
Ruponen, Marika; Rusanen, Henna; Laitinen, Riikka. 2020. Dissolution and permeability properties of co-amorphous formulations of hydrochlorothiazide Journal of pharmaceutical sciences 109 7: 2252-2261. 2020
Sormunen, Henri; Ruponen, Marika; Laitinen, Riikka. 2019. The effect of co-amorphization of glibenclamide on its dissolution properties and permeability through an MDCKII-MDR1 cell layer International journal of pharmaceutics 570: 118653. 2019
Ojarinta, Rami; Saarinen, Jukka; Strachan, Clare J; Korhonen, Ossi; Laitinen, Riikka. 2018. Preparation and characterization of multi-component tablets containing co-amorphous salts: combining multimodal non-linear optical imaging with established analytical methods European journal of pharmaceutics and biopharmaceutics 132: 112-126. 2018
Ruponen, Marika; Visti, Maiju; Ojarinta, Rami; Laitinen, Riikka. 2018. Permeability of glibenclamide through a PAMPA membrane: the effect of co-amorphization EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 129: 247-256. 2018
Korhonen Kristiina, Smolander Elina, Korhonen Ossi, Ketolainen Jarkko, Laitinen Riikka. 2017. Effect of storage on the physical stability of thin polymethacrylate-perphenazine films. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 104: 293-301. 2017
Laitinen R, Räty J, Korhonen K, Ketolainen J, Peiponen K-E. 2017. Reflectometric monitoring of the dissolution process of thin polymeric films. INTERNATIONAL JOURNAL OF PHARMACEUTICS 523 1: 127-132. 2017
Laitinen Riikka, Löbmann Korbinian, Grohganz Holger, Priemel Petra, Strachan Clare J, Rades Thomas. 2017. Supersaturating drug delivery systems: the potential of co-amorphous drug formulations. INTERNATIONAL JOURNAL OF PHARMACEUTICS 532 1: 1-12. 2017
Ojarinta R, Lerminiaux L, Laitinen R. 2017. Spray drying of poorly soluble drugs from aqueous arginine solution. INTERNATIONAL JOURNAL OF PHARMACEUTICS 532 1: 289-298. 2017
Ojarinta Rami, Heikkinen Aki T, Sievänen Elina, Laitinen Riikka. 2016. Dissolution behavior of co-amorphous amino acid-indomethacin mixtures: The ability of amino acids to stabilize the supersaturated state of indomethacin. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 2017; 112: 85-95. 2016
Korhonen Ossi, Pajula Katja, Laitinen Riikka. 2016. Rational excipient selection for co-amorphous formulations. EXPERT OPINION ON DRUG DELIVERY 2017; 14 4: 551-569. 2016
Korhonen Kristiina, Poikolainen Mirja, Korhonen Ossi, Ketolainen Jarkko, Laitinen Riikka. 2016. Systematic evaluation of a spraying method for preparing thin Eudragit-drug films by Design of Experiments. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY 35: 241-251. 2016
Craye Goedele, Löbmann Korbinian, Grohganz Holger, Rades Thomas, Laitinen Riikka. 2015. Characterization of Amorphous and Co-Amorphous Simvastatin Formulations Prepared by Spray Drying. MOLECULES 20 12: 21532-21548. 2015
Heikkinen Aki T, DeClerck L, Löbmann K, Grohganz H, Rades T, Laitinen Riikka. 2015. Dissolution properties of co-amorphous drug-amino acid formulations in buffer and biorelevant media. Die Pharmazie - An International Journal of Pharmaceutical Sciences 70 7: 452-457. 2015
Korhonen Kristiina, Granqvist Niko, Ketolainen Jarkko, Laitinen Riikka. 2015. Monitoring of Drug Release Kinetics from Thin Polymer Films by Multi-Parametric Surface Plasmon Resonance. INTERNATIONAL JOURNAL OF PHARMACEUTICS 494 1: 531-536. 2015
Grohganz Holger, Priemel Petra A, Löbmann Korbinian, Nielsen Line H, Laitinen Riikka, Mullertz Anette, Van den Mooter Guy, Rades Thomas. 2014. Refining stability and dissolution rate of amorphous drug formulations. EXPERT OPINION ON DRUG DELIVERY 11: 977-989. 2014
Ketolainen Jarkko, Korhonen Ossi, Laitinen Riikka, Simonaho Simo-Pekka, Molnár Ferdinand. 2014. Pharmaceutical solids and processes. DOSIS : FARMASEUTTINEN AIKAKAUSKIRJA 30 3: 195. 2014
Laitinen Riikka, Löbmann Korbinian, Grohganz Holger, Strachan Clare, Rades Thomas. 2014. Amino acids as co-amorphous excipients for simvastatin and glibenclamide: physical properties and stability. Molecular Pharmaceutics 11: 2381-2389. 2014
Löbmann Korbinian, Laitinen Riikka, Strachan Clare, Rades Thomas, Grohganz Holger. 2013. Amino acids as co-amorphous stabilizers for poorly water-soluble drugs - Part 2: Molecular interactions. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 85: 882-888. 2013
Priemel Petra A, Laitinen Riikka, Grohganz Holger, Rades Thomas, Strachan Clare J. 2013. In situ amorphisation of indomethacin with Eudragit® E during dissolution. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 85: 1259-1265. 2013
Priemel Petra A, Laitinen Riikka, Barthold Sarah, Grohganz Holger, Lehto Vesa-Pekka, Rades Thomas, Strachan Clare J. 2013. Inhibition of surface crystallisation of amorphous indomethacin particles in physical drug-polymer mixtures. INTERNATIONAL JOURNAL OF PHARMACEUTICS 456: 301-306. 2013
Laitinen Riikka, Honkakoski Paavo, Järvinen Kristiina, Ketolainen Jarkko. 2013. Farmasian teknologia ja biofarmasia - uusia teknologioita lääkekehitykseen monitieteellisellä yhteistyöllä: Ahonen R, Laitinen K, Lapinjoki S, Mensalo P, Ranta V-P, Ylikangas H (toim)., Muutosten vuosikymmen : Itä-Suomen yliopiston farmasian laitos 40 vuotta. Publications of the University of Eastern Finland. General Series 13. 24-30. 2013
Löbmann Korbinian, Laitinen Riikka, Grohganz Holger, Strachan Clare, Rades Thomas, Gordon Keith C. 2013. A theoretical and spectroscopic study of co-amorphous naproxen and indomethacin. INTERNATIONAL JOURNAL OF PHARMACEUTICS 453: 80-87. 2013
Löbmann Korbinian, Grohganz Holger, Laitinen Riikka, Strachan Clare, Rades Thomas. 2013. Amino acids as co-amorphous stabilizers for poorly water soluble drugs - Part 1: Preparation, stability and dissolution enhancement. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 85: 873-881. 2013
Laitinen Riikka, Löbmann Korbinian, Strachan Clare J, Grohganz Holger, Rades Thomas. 2013. Emerging trends in the stabilization of amorphous drugs. INTERNATIONAL JOURNAL OF PHARMACEUTICS 453: 65-79. 2013
Hakkarainen Jenni J, Pajander Jari, Laitinen Riikka, Suhonen Marjukka, Forsberg Markus M. 2012. Similar molecular descriptors determine the in vitro drug permeability in endothelial and epithelial cells INTERNATIONAL JOURNAL OF PHARMACEUTICS 436 1-2: 426-443. 2012
Löbmann Korbinian, Strachan Clare, Grohganz Holger, Rades Thomas, Korhonen Ossi, Laitinen Riikka. 2012. Co-amorphous simvastatin and glipizide combinations show improved physical stability without evidence of intermolecular interactions. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 81: 159-169. 2012
Simonaho Simo-Pekka, Laitinen Riikka, Rimpiläinen Ville, Heikkinen Lasse, Vauhkonen Marko, Paaso Janne, Juuti Mikko, Ketolainen Jarkko. 2012. PROMIS Centre - innovative pharmaceutical manufacturing research and technology development in Kuopio, Finland. DOSIS : FARMASEUTTINEN AIKAKAUSKIRJA 28 3: 251-260. 2012
Ciurczak Emil, Ketolainen Jarkko, Laitinen Riikka, Aaltonen Jaakko, Lindén Hans. 2011. Taking PAT to the next level. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 42: 1-2. 2011
Löbmann Korbinian, Laitinen Riikka, Grohganz Holger, Gordon Keith C, Strachan Clare, Rades Thomas. 2011. Coamorphous drug systems: enhanced physical stability and dissolution rate of indomethacin and naproxen. Molecular Pharmaceutics 8: 1919-1928. 2011
Turunen Elina, Mannila Janne, Laitinen Riikka, Riikonen Joakim, Lehto Vesa-Pekka, Järvinen Tomi, Ketolainen Jarkko, Järvinen Kristiina, Jarho Pekka. 2011. Fast-dissolving sublingual solid dispersion and cyclodextrin complex increase the absorption of perphenazine in rabbits. JOURNAL OF PHARMACY AND PHARMACOLOGY 63: 19 - 25. 2011
Laitinen R, Lahtinen J, Silfsten P, Vartiainen E, Jarho P & Ketolainen J. 2010. An optical method for continuous monitoring of the dissolution rate of pharmaceutical powders. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 52: 181 - 189. 2010
Laitinen R, Suihko E, Bjorkqvist M, Riikonen J, Lehto V-P, Jarvinen K & Ketolainen J. 2010. Perphenazine solid dispersions for orally fast-disintegrating tablets: physical stability and formulation DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY 36 5: 601 - 613. 2010
Laitinen R, Suihko E, Toukola K, Björkqvist M, Riikonen J, Lehto V-P, Järvinen K, Ketolainen J. 2009. Intraorally fast-dissolving particles of a poorly soluble drug: Preparation and in vitro characterization. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 71: 271-281. 2009
Laitinen R. 2009. Physical Modification of Drug Release Controlling Structures : Hydrophobic Matrices and Fast Dissolving Particles. Kuopion yliopiston julkaisuja A. Farmaseuttiset tieteet. 2009
Mäki R, Suihko E, Rost S, Heiskanen M, Murtomaa M, Lehto V-P, Ketolainen J. 2007. Modifying drug release and tablet properties of starch acetate tablets by dry powder agglomeration. JOURNAL OF PHARMACEUTICAL SCIENCES 96 2: 438-447. 2007
Mäki R, Suihko E, Korhonen O, Pitkänen H, Niemi R, Lehtonen M, Ketolainen J. 2006. Controlled release of saccharides from matrix tablets. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 62: 163-170. 2006