Tarja Kokkola

Katisko, Kasper; Cajanus, Antti; Huber, Nadine; Jääskeläinen, Olli; Kokkola, Tarja; Kärkkäinen, Virve; Rostalski, Hannah; Hartikainen, Paivi; Koivisto, Anne M; Hannonen, Sanna; Lehtola, Juha-Matti; Korhonen, Ville E; Helisalmi, Seppo; Koivumaa-Honkanen, Heli; Herukka, Sanna-Kaisa; Remes, Anne M; Solje, Eino; Haapasalo, Annakaisa. 2021. GFAP as a biomarker in frontotemporal dementia and primary psychiatric disorders: diagnostic and prognostic performance Journal of neurology neurosurgery and psychiatry [Epub ahead of print 29 June 2021]: 1 - 8. 2021

Kårlund, Anna; Kääriäinen, Teemu; Kostamo, Vili M; Kokkola, Tarja; Kolehmainen, Marjukka; Lakka, Timo A; Pihlajamäki, Jussi; Manninen, Albert. 2021. Oxygen-18 and Carbon-13 isotopes in eCO 2 and erythrocytes carbonic anhydrase activity of Finnish prediabetic population Journal of breath research 15 2: 021001. 2021

Tura, Andrea; Grespan, Eleonora; Göbl, Christian S; Koivula, Robert W; Franks, Paul W; Pearson, Ewan R; Walker, Mark; Forgie, Ian M; Giordano, Giuseppe N; Pavo, Imre; Ruetten, Hartmut; Dermitzakis, Emmanouil T; McCarthy, Mark I; Pedersen, Oluf; Schwenk, Jochen M; Adamski, Jerzy; De Masi, Federico; Tsirigos, Konstantinos D; Brunak, Søren; Viñuela, Ana et al. [incl. Kokkola, Tarja; Vangipurapu Jaga. 2021. Profiles of glucose metabolism in different prediabetes phenotypes, classified by fasting glycemia, 2-hour OGTT, glycated hemoglobin, and 1-hour OGTT: An IMI DIRECT study Diabetes [Epub ahead of print 20 Aug 2021]: 1-15. 2021

Atabaki-Pasdar, Naeimeh; Ohlsson, Mattias; Viñuela, Ana; Frau, Francesca; Pomares-Millan, Hugo; Haid, Mark; Jones, Angus G; Thomas, E Louise; Koivula, Robert W; Kurbasic, Azra; Mutie, Pascal M; Fitipaldi, Hugo; Fernandez, Juan; Dawed, Adem Y; Giordano, Giuseppe N; Forgie, Ian M; McDonald, Timothy J; Rutters, Femke; Cederberg, Henna; Chabanova, Elizaveta et al. [Incl. Kokkola, Tarja; Laakso Markku;. 2020. Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts PLoS medicine 17 6: e1003149. 2020

Bar, Noam; Korem, Tal; Weissbrod, Omer; Zeevi, David; Rothschild, Daphna; Leviatan, Sigal; Kosower, Noa; Lotan-Pompan, Maya; Weinberger, Adina; Le Roy, Caroline I; Menni, Cristina; Visconti, Alessia; Falchi, Mario; Spector, Tim D; Adamski, Jerzy; Franks, Paul W; Pedersen, Oluf; Segal, Eran; The IMI DIRECT Consortium [incl. Kuulasmaa, Teemu; Kokkola, Tarja; Laakso, Markku; Vangipurapu, Jagadish; Ce. 2020. A reference map of potential determinants for the human serum metabolome. Nature 588: 135-140. 2020

Bizzotto, Roberto; Jennison, Christopher; Jones, Angus G; Kurbasic, Azra; Tura, Andrea; Kennedy, Gwen; Bell, Jimmy D; Thomas, E Louise; Frost, Gary; Eriksen, Rebeca; Koivula, Robert W; Brage, Soren; Kaye, Jane; Hattersley, Andrew T; Heggie, Alison; McEvoy, Donna; 't Hart, Leen M; Beulens, Joline W; Elders, Petra; Musholt, Petra B; et al. for the IMI DIRECT consortium [incl; Kokkola, Tarja]. 2020. Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study Diabetes care 2021; 44 2: 511-518. 2020

Eriksen, Rebeca; Perez, Isabel Garcia; Posma, Joram M; Haid, Mark; Sharma, Sapna; Prehn, Cornelia; Thomas, Louise E; Koivula, Robert W; Bizzotto, Roberto; Mari, Andrea; Giordano, Giuseppe N; Pavo, Imre; Schwenk, Jochen M; De Masi, Federico; Tsirigos, Konstantinos D; Brunak, Søren; Viñuela, Ana; Mahajan, Anubha; McDonald, Timothy J [incl. Kokkola, Tarja]. 2020. Dietary metabolite profiling brings new insight into the relationship between nutrition and metabolic risk: An IMI DIRECT study EBioMedicine 58: 102932. 2020

Gudmundsdottir, Valborg; Pedersen, Helle Krogh; Mazzoni, Gianluca; Allin, Kristine H; Artati, Anna; Beulens, Joline W; Banasik, Karina; Brorsson, Caroline; Cederberg, Henna; Chabanova, Elizaveta; De Masi, Federico; Elders, Petra J; Forgie, Ian; Giordano, Giuseppe N; Grallert, Harald; Gupta, Ramneek; Haid, Mark; Hansen, Torben; Hansen, Tue H; Hattersley, Andrew T; et al. [incl. Kokkola, Tarja; Laak. 2020. Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study Genome medicine 12 1: 109. 2020

Koivula, RW; Atabaki-Pasdar, N; Giordano, GN; White, T; Adamski, J; Bell, JD; Beulens, J; Brage, S; Brunak, S; De Masi, F; Dermitzakis, ET; Forgie, IM; Frost, G; Hansen, T; Hansen, TH; Hattersley, A; Kokkola, T; Kurbasic, A; Laakso, M; Mari, A et al. for the IMI DIRECT Consortium. 2020. The Role of Physical Activity in Metabolic Homeostasis Before and After the Onset of Type 2 Diabetes: An IMI DIRECT Study Diabetologia 63 4: 744-756. 2020

Tenhunen, Jonna; Kokkola, Tarja; Huovinen, Marjo; Rahnasto-Rilla, Minna; Lahtela-Kakkonen, Maija. 2020. Impact of Structurally Diverse BET Inhibitors on SIRT1 Gene 741: 144558. 2020

Wilman, HR; Parisinos, CA; Atabaki-Pasdar, N; Kelly, M; Thomas, EL; Neubauer, S; Jennison, C; Ehrhardt, B; Baum, P; Schoelsch, C; Freijer, J; Grempler, R; Graefe-Mody, U; Hennige, A; Dings, C; Lehr, T; Scherer, N; Sihinecich, I; Pattou, F; Raverdi, V; et al. [Incl. Laakso, M; Kokkola, T; Kuulasmaa, T]. 2019. Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration Journal of hepatology 71 3: 594-602. 2019

Seifert, T; Malo, M; Kokkola, T; Stéen, EJL; Meinander, K; Wallén, EAA; Jarho, EM; Luthman, K. 2019. A scaffold replacement approach towards new sirtuin 2 inhibitors Bioorganic and medicinal chemistry 2020; 28 2: 115231. 2019

Koivula, RW; Forgie, IM; Kurbasic, A; Viñuela, A; Heggie, A; Giordano, GN; Hansen, TH; Hudson, M; Koopman, ADM; Rutters, F; Siloaho, M; Allin, KH; Brage, S; Brorsson, CA; Dawed, AY; De Masi, F; Groves, CJ; Kokkola, T; Mahajan, A; Perry, MH; et al.; IMI DIRECT Consortium (incl. Laakso, M). 2019. Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium Diabetologia 62 9: 1601-1615. 2019

Kärkkäinen, J; Gynther, M; Kokkola, T; Petsalo, A; Auriola, S; Lahtela-Kakkonen, M; Laine, K; Rautio, J; Huttunen, KM. 2018. Structural properties for selective and efficient L-type amino acid transporter 1 (LAT1) mediated cellular uptake INTERNATIONAL JOURNAL OF PHARMACEUTICS 544 1: 91-99. 2018

Lappalainen, J; Oksala, NKJ; Laaksonen, DE; Khanna, S; Kokkola, T; Kaarniranta, K; Sen, CK; Atalay, M. 2018. Suppressed heat shock protein response in the kidney of exercise-trained diabetic rats SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS 28 7: 1808-1817. 2018

Modi, Shalem; Yaluri, Nagendra; Kokkola, Tarja. 2018. Strigolactone GR24 and pinosylvin attenuate adipogenesis and inflammation of white adipocytes. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 499 2: 164-169. 2018

Shalem, Raju Modi; Kokkola, Tarja. 2018. Strigolactone GR24 upregulates target genes of the cytoprotective transcription factor Nrf2 in skeletal muscle F1000research 7: 1459. 2018

Modi S, Yaluri N, Kokkola T, Laakso M. 2017. Plant-derived compounds strigolactone GR24 and pinosylvin activate SIRT1 and enhance glucose uptake in rat skeletal muscle cells. Scientific Reports 7: 17606. 2017

Yaluri N, Modi S, Kokkola T. 2016. Simvastatin induces insulin resistance in L6 skeletal muscle myotubes by suppressing insulin signaling, GLUT4 expression and GSK-3ß phosphorylation. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 480 2: 194-200. 2016

Rahnasto-Rilla Minna, Kokkola Tarja, Jarho Elina, Lahtela-Kakkonen Maija, Moaddel Ruin. 2015. N-Acylethanolamines Bind to SIRT6. CHEMBIOCHEM : A EUROPEAN JOURNAL OF CHEMICAL BIOLOGY 17 (2016) 1: 77-81. 2015

Yrjölä Sari, Parkkari Teija, Navia-Paldanius Dina, Laitinen Tuomo, Kaczor Agnieszka A, Kokkola Tarja, Adusei-Mensah Frank, Savinainen Juha R, Laitinen Jarmo T, Poso Antti, Alexander Amy, Penman June, Stott Lisa, Anskat Marie, Irving Andrew J, Nevalainen Tapio J. 2015. Potent and selective N-(4-sulfamoylphenyl)thiourea-based GPR55 agonists. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 107 (2016): 119-132. 2015

Yaluri Nagendra, Modi Shalem, López Rodríguez Maykel, Stancáková Alena, Kuusisto Johanna, Kokkola Tarja, Laakso Markku. 2015. Simvastatin Impairs Insulin Secretion by Multiple Mechanisms in MIN6 Cells. PLOS ONE [ONLINE] 10 11: e0142902. 2015

Pesonen Maija, Storvik Markus, Kokkola Tarja, Rysä Jaana, Vähäkangas Kirsi, Pasanen Markku. 2015. Transcriptomic Analysis of Human Primary Bronchial Epithelial Cells after Chloropicrin Treatment. CHEMICAL RESEARCH IN TOXICOLOGY 28 10: 1926-1935. 2015

Kokkola Tarja, Suuronen Tiina, Pesonen Maija, Filippakopoulos Panagis, Salminen Antero, Jarho Elina M, Lahtela-Kakkonen Maija. 2015. BET Inhibition Upregulates SIRT1 and Alleviates Inflammatory Responses. CHEMBIOCHEM : A EUROPEAN JOURNAL OF CHEMICAL BIOLOGY 16: 1997-2001. 2015

Kokkonen Piia, Kokkola Tarja, Suuronen Tiina, Poso Antti, Jarho Elina, Lahtela-Kakkonen Maija. 2015. Virtual screening approach of sirtuin inhibitors results in two new scaffolds. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 76: 27-32. 2015

Kokkola Tarja, Suuronen Tiina, Molnár Ferdinand, Määttä Juha, Salminen Antero, Jarho Elina M, Lahtela-Kakkonen Maija. 2014. AROS has a context-dependent effect on SIRT1. FEBS LETTERS 588: 1523-1528. 2014

Kokkonen Piia, Rahnasto-Rilla Minna, Mellini Paolo, Jarho Elina, Lahtela-Kakkonen Maija, Kokkola Tarja. 2014. Studying SIRT6 regulation using H3K56 based substrate and small molecules. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 63: 71-76. 2014

Oksala Niku KJ, Ekmekci F Güler, Özsoy Ergi, Kirankaya Serife, Kokkola Tarja, Emecen Güzin, Lappalainen Jani, Kaarniranta Kai, Atalay Mustafa. 2014. Natural thermal adaptation increases heat shock protein levels and decreases oxidative stress. Redox Biology 3: 25-28. 2014

Seifert Tina, Malo Marcus, Kokkola Tarja, Engen Karin, Fridén-Saxin Maria, Wallén Erik A, Lahtela-Kakkonen Maija, Jarho Elina M, Luthman Kristina. 2014. Chroman-4-one- and Chromone-based Sirtuin 2 Inhibitors with Antiproliferative Properties in Cancer Cells. JOURNAL OF MEDICINAL CHEMISTRY 57: 9870-9888. 2014

Mellini Paolo, Kokkola Tarja, Suuronen Tiina, Salo Heikki S, Tolvanen Laura, Mai Antonello, Lahtela-Kakkonen Maija, Jarho Elina M. 2013. Screen of pseudopeptidic inhibitors of human sirtuins 1-3: Two lead compounds with antiproliferative effects in cancer cells. JOURNAL OF MEDICINAL CHEMISTRY 56 17: 6681-6695. 2013

Atalay Mustafa, Bilginoglu Ayca, Kokkola Tarja, Oksala Niku, Turan Belma. 2011. Treatments with sodium selenate or doxycycline offset diabetes-induced perturbations of thioredoxin-1 levels and antioxidant capacity. MOLECULAR AND CELLULAR BIOCHEMISTRY 351: 125-131. 2011

Kokkola Tarja, Kruse Claudia, Roy-Pogodzik Eva-Maria, Pekkinen Jenna, Bauch Carola, Hönck Hans-Hinrich, Hennemann Hanjo, Kreienkamp Hans-Jürgen. 2011. Somatostatin receptor 5 is palmitoylated by the interacting ZDHHC5 palmitoyltransferase. FEBS LETTERS 585: 2665-2670. 2011

Breusing N, Grune T, Andrisic L, Atalay M, Bartosz G, Biasi F, Borovic S, Bravo L, Casals I, Casillas R & et al.. 2010. An inter-laboratory validation of methods of lipid peroxidation measurements in UVA-treated human plasma samples. FREE RADICAL RESEARCH 44 10: 1203-1215. 2010

Kokkola T, Vaittinen M, Laitinen JT. 2007. Inverse agonist exposure enhances ligand binding and G protein activation of the human MT1 melatonin receptor, but leads to receptor down-regulation. JOURNAL OF PINEAL RESEARCH 43: 255-262. 2007

Savinainen JR, Kokkola T, Salo OMH, Poso A, Järvinen T, Laitinen JT. 2005. Identification of WIN55212-3 as a competitive neutral antagonist of the human cannabinoid CB2 receptor. BRITISH JOURNAL OF PHARMACOLOGY 145: 636-645. 2005

Kokkola T, Salo OMH, Poso A, Laitinen JT. 2005. The functional role of cysteines adjacent to the NRY motif of the human MT1 melatonin receptor. JOURNAL OF PINEAL RESEARCH 39: 1-11. 2005

Kokkola T. 2005. G protein-couples receptors. Teoksessa: Hänninen O (toim.), Biological, Physiological and Health Sciences.UNESCO Eolss Publisher. Encyclopedia of Life Support Systems (EOLSS). ss. [16] http://www.eolss.net. 2005

Kokkola T, Savinainen JR, Mönkkönen KS, Retamal MD, Laitinen JT. 2005. S-Nitrosothiols modulate G protein-coupled receptor signaling in a reversible and highly receptor-specific manner BMC CELL BIOLOGY 6: 21. 2005

Kokkola T, Foord SM, Watson M-A, Vakkuri O, Laitinen JT. 2003. Important amino acids for the function of the human MT1 melatonin receptor. BIOCHEMICAL PHARMACOLOGY 65: 1463-1471. 2003

Kokkola T. 2003. Mapping the Structure and Function of the Human MTI Melatonin Receptor. Kuopion yliopiston julkaisuja C. Luonnontieteet ja ympäristötieteet. 2003

Kokkola T, Laitinen JT. 1998. Melatonin receptor genes ANNALS OF MEDICINE (HELSINKI) 30: 88-94. 1998

Kokkola T, Watson M-A, White J, Dowell S, Foord SM, Laitinen JT. 1998. Mutagenesis of human Mel1a melatonin receptor expressed in yeast reveals domains important for receptor function. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 249: 531-536. 1998

Pesonen M, Vakkuri O, Kokkola T, Laitinen JT. 1998. TCDD alters melatonin metabolism in fish hepatocytes. Teoksessa: (toim.), International Congress of Pathophysiology. ss. 99. 1998

Kokkola T, Hyttinen J-M, Laitinen JT. 1997. Molecular cloning of a G protein-coupled melatonin receptor from the chicken. Teoksessa: Webb SM, Puig-Domingo M, MÝller M, Pévet P (toim.), Pineal Update: From Molecular Mechanisms to Clinical Implications. Proceedings of the 7th Colloquium of the European Pineal Society.PJD Publications. ss. 231-234. 1997

Navajas C, Kokkola T, Poso A, Honka N, Gynther J, Laitinen JT. 1996. A rhodopsin-based model for melatonin recognition at its G protein-coupled receptor. EUROPEAN JOURNAL OF PHARMACOLOGY 304: 173-183. 1996

Pohjanvirta R, Laitinen JT, Vakkuri O, Lindén J, Kokkola T, Unkila M, Tuomisto J. 1996. Mechanism by which 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) reduces circulating melatonin levels in the rat. TOXICOLOGY 107: 85-97. 1996

Laitinen JT, Laitinen KSM, Kokkola T. 1995. Cholinergic signaling in the rat pineal gland CELLULAR AND MOLECULAR NEUROBIOLOGY 15 2: 177-190. 1995

Yhteystiedot

Organisaatio

Sähköposti

Puhelin

Avainsanat

Julkaisut