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Tarja Malm

Tarja Malm

Professori

Terveystieteiden tiedekunta, A. I. Virtanen -instituutti

tarja.malm@uef.fi | 040 355 2209

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Tiedot Julkaisut

Johdan Neuroinflammaation tutkimusryhmää. Pyrimme selvittämään, mikä säätelee mikrogliasolujen toimintahäiriöitä eri aivosairauksissa.
Tutkimusryhmämme kotisivut:
https://sites.uef.fi/tarja-malm-group/research-details/

Tutkimusryhmät

In vitro ja ex vivo elektrofysiologian keskus 01.01.2020 -
Neuroinflammation research group
NPH and Early AD 01.01.2010 -

Projektit

MINERVA 01.06.2022 - 31.05.2025
Neuro-Innovation 01.05.2021 - 30.04.2026

Avainsanat

aivohalvaus Alzheimerin tauti biomarkkerit elävien solujen kuvantaminen epigenetiikka neuroinflammaatio Parkinsonin tauti solunulkoinen vesikkeli

Julkaisut

107 kappaletta

Additive Behavioral Improvement after Combined Cell Therapy and Rehabilitation Despite Long-Term Microglia Presence in Stroke Rats
Bakreen, Abdulhameed; Juntunen, Miia; Dunlop, Yannick; Ugidos, Irene F.; Malm, Tarja; Miettinen, Susanna; Jolkkonen, Jukka. International journal of molecular sciences 22 4: 1512. 2021
Regular Physical Exercise Modulates Iron Homeostasis in the 5xFAD Mouse Model of Alzheimer's Disease
Belaya, Irina; Kucháriková, Nina; Górová, Veronika; Kysenius, Kai; Hare, Dominic J.; Crouch, Peter J.; Malm, Tarja; Atalay, Mustafa; White, Anthony R.; Liddell, Jeffrey R.; Kanninen, Katja M.. International journal of molecular sciences 22 16: 8715. 2021
"Time window" effect of Yoda1-evoked Piezo1 channel activity during mouse skeletal muscle differentiation
Bosutti, Alessandra; Giniatullin, Arthur; Odnoshivkina, Yulia; Giudice, Luca; Malm, Tarja; Sciancalepore, Marina; Giniatullin, Rashid; D'Andrea, Paola; Lorenzon, Paola; Bernareggi, Annalisa. Acta physiologica 233 4: e13702. 2021
Microglia-like Cells Promote Neuronal Functions in Cerebral Organoids
Fagerlund, Ilkka; Dougalis, Antonios; Shakirzyanova, Anastasia; Gómez-Budia, Mireia; Pelkonen, Anssi; Konttinen, Henna; Ohtonen, Sohvi; Fazaludeen, Mohammad Feroze; Koskuvi, Marja; Kuusisto, Johanna; Hernández, Damián; Pebay, Alice; Koistinaho, Jari; Rauramaa, Tuomas; Lehtonen, Šárka; Korhonen, Paula; Malm, Tarja. Cells 2022; 11 1: 124. 2021
Systemic cross-talk between brain, gut, and peripheral tissues in glucose homeostasis: effects of exercise training (CROSSYS). Exercise training intervention in monozygotic twins discordant for body weight
Heiskanen, Marja A; Honkala, Sanna M; Hentilä, Jaakko; Ojala, Ronja; Lautamäki, Riikka; Koskensalo, Kalle; Lietzen, Martin S; Saunavaara, Virva; Saunavaara, Jani; Helmio, Mika; Löyttyniemi, Eliisa; Nummenmaa, Lauri; Collado, Maria C; Malm, Tarja; Lahti, Leo; Pietiläinen, Kirsi H; Kaprio, Jaakko; Rinne, Juha O; Hannukainen, Jarna C. BMC sports science, medicine & rehabilitation 13 1: 16. 2021
Extracellular Vesicles from Human Teeth Stem Cells Trigger ATP Release and Promote Migration of Human Microglia through P2X4 Receptor/MFG-E8-Dependent Mechanisms
Jonavice, Ugne; Romenskaja, Diana; Kriauciunaite, Karolina; Jarmalaviciute, Akvile; Pajarskiene, Justina; Kašeta, Vytautas; Tunaitis, Virginijus; Malm, Tarja; Giniatulin, Rashid; Pivoriunas, Augustas. International journal of molecular sciences 22 20: 10970. 2021
An arylthiazyne derivative is a potent inhibitor of lipid peroxidation and ferroptosis providing neuroprotection in vitro and in vivo
Keuters, Meike Hedwig; Keksa-Goldsteine, Velta; Dhungana, Hiramani; Huuskonen, Mikko T; Pomeshchik, Yuriy; Savchenko, Ekaterina; Korhonen, Paula K; Singh, Yajuvinder; Wojciechowski, Sara; Lehtonen, Šárka; Kanninen, Katja M; Malm, Tarja; Sirviö, Jouni; Muona, Anu; Koistinaho, Milla; Goldsteins, Gundars; Koistinaho, Jari. Scientific reports 11 1: 3518. 2021
Alzheimerin taudin uudet riskigeenit - keskiössä mikrogliasolut
Martiskainen, Henna; Takalo, Mari; Konttinen, Henna; Malm, Tarja; Haapasalo, Annakaisa; Leinonen, Ville; Hiltunen, Mikko. Duodecim 137 13: 1375- 1382. 2021
Functional Characterization of Human Pluripotent Stem Cell-Derived Models of the Brain with Microelectrode Arrays
Pelkonen, Anssi; Pistono, Cristiana; Klecki, Pamela; Gómez-Budia, Mireia; Dougalis, Antonios; Konttinen, Henna; Stanová, Iveta; Fagerlund, Ilkka; Leinonen, Ville; Korhonen, Paula; Malm, Tarja. Cells 2022; 11 1: 106. 2021
Glia-Derived Extracellular Vesicles: Role in Central Nervous System Communication in Health and Disease
Pistono, Cristiana; Bister, Nea; Stanová, Iveta; Malm, Tarja. Frontiers in cell and developmental biology 8: 623771. 2021
Systemic inflammation induced changes in protein expression of ABC transporters and ionotropic glutamate receptor subunit 1 in the cerebral cortex of familial Alzheimer`s disease mouse model
Puris, Elena; Auriola, Seppo; Korhonen, Paula; Loppi, Sanna; Kanninen, Katja M; Malm, Tarja; Koistinaho, Jari; Gynther, Mikko. Journal of pharmaceutical sciences 110 12: 3953-3962. 2021
Metabolomic and lipidomic changes triggered by lipopolysaccharide-induced systemic inflammation in transgenic APdE9 mice
Puris, Elena; Kouril, Štepán; Najdekr, Lukáš; Loppi, Sanna; Korhonen, Paula; Kanninen, Katja M.; Malm, Tarja; Koistinaho, Jari; Friedecký, David; Gynther, Mikko. Scientific reports 11 1: 13076. 2021
High cerebrospinal amyloid-β 42 is associated with normal cognition in individuals with brain amyloidosis
Sturchio, Andrea; Dwivedi, Alok K.; Young, Christina B.; Malm, Tarja; Marsili, Luca; Sharma, Jennifer S.; Mahajan, Abhimanyu; Hill, Emily J.; Andaloussi, Samir EL; Poston, Kathleen L.; Manfredsson, Fredric P.; Schneider, Lon S.; Ezzat, Kariem; Espay, Alberto J.. EClinicalMedicine 38: 100988. 2021
Microglia Development and Maturation and Its Implications for Induction of Microglia-Like Cells from Human iPSCs
Wurm, Johannes; Konttinen, Henna; Andressen, Christian; Malm, Tarja; Spittau, Björn. International journal of molecular sciences 22 6: 3088. 2021
Astrocyte remodeling in the beneficial effects of long-term voluntary exercise in Alzheimer's disease
Belaya, Irina; Ivanova, Mariia; Sorvari, Annika; Ilicic, Marina; Loppi, Sanna; Koivisto, Hennariikka; Varricchio, Alessandra; Tikkanen, Heikki; Walker, Frederick R; Atalay, Mustafa; Malm, Tarja; Grubman, Alexandra; Tanila, Heikki; Kanninen, Katja M. Journal of neuroinflammation 17 1: 271. 2020
Hypoxia and extracellular vesicles: A review on methods, vesicular cargo and functions
Bister, Nea; Pistono, Cristiana; Huremagic, Benjamin; Jolkkonen, Jukka; Giugno, Rosalba; Malm, Tarja. Journal of extracellular vesicles 10 1: e12002. 2020
Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-ß from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy
Carare, RO; Aldea, R; Agarwal, N; Bacskai, BJ; Bechman, I; Boche, D; Bu, G; Bulters, D; Clemens, A; Counts, SE; de Leon, M; Eide, PK; Fossati, S; Greenberg, SM; Hamel, E; Hawkes, CA; Koronyo-Hamaoui, M; Hainsworth, AH; Holtzman, D; Ihara, M; et al [incl. Kanninen, K; Leinonen, V; Malm, T]. Alzheimer's & dementia : diagnosis, assessment & disease monitoring 21 1: e12053. 2020
Impairment of mitochondrial function by particulate matter: Implications for the brain
Chew, S; Kolosowska, N; Saveleva, L; Malm, T; Kanninen, KM. Neurochemistry international 135: 104694. 2020
Urban air particulate matter induces mitochondrial dysfunction in human olfactory mucosal cells
Chew, Sweelin; Lampinen, Riikka; Saveleva, Liudmila; Korhonen, Paula; Mikhailov, Nikita; Grubman, Alexandra; Polo, Jose M; Wilson, Trevor; Komppula, Mika; Rönkkö, Teemu; Gu, Cheng; Mackay-Sim, Alan; Malm, Tarja; White, Anthony R; Jalava, Pasi; Kanninen, Katja M. Particle and fibre toxicology 17 1: 18. 2020
Glial smog: Interplay between air pollution and astrocyte-microglia interactions
Gómez-Budia, Mireia; Konttinen, Henna; Saveleva, Liudmila; Korhonen, Paula; Jalava, Pasi; Kanninen, Katja; Malm, Tarja. Neurochemistry international 136: 104715. 2020
Intracerebral overexpression of miR-669c is protective in mouse ischemic stroke model by targeting MyD88 and inducing alternative microglial/macrophage activation
Kolosowska, Natalia; Gotkiewicz, Maria; Dhungana, Hiramani; Giudice, Luca; Giugno, Rosalba; Box, Daphne; Huuskonen, Mikko T.; Korhonen, Paula; Scoyni, Flavia; Kanninen, Katja M.; Ylä-Herttuala, Seppo; Turunen, Tiia A.; Turunen, Mikko P.; Koistinaho, Jari; Malm, Tarja. Journal of neuroinflammation 17: 194. 2020
Peripheral inflammation preceeding ischemia impairs neuronal survival through mechanisms involving miR-127 in aged animals
Loppi, Sanna; Korhonen, Paula; Bouvy-Liivrand, Maria; Cagliola, Simone; Turunen, Tiia A; Turunen, Mikko P; Hernandez de Sande, Ana; Kolosowska, Natalia; Scoyni, Flavia; Rosell, Anna; García-Berrocoso, Teresa; Lemarchant, Sighild; Dhungana, Hiramani; Montaner, Joan; Koistinaho, Jari; Kanninen, Katja M; Kaikkonen, Minna U; Giugno, Rosalba; Heinäniemi, Merja; Malm, Tarja. Aging cell 2021; 20 1: e13287. 2020
Disentangling the Amyloid Pathways: A Mechanistic Approach to Etiology
Malmberg, Maja; Malm, Tarja; Gustafsson, Oskar; Sturchio, Andrea; Graff, Caroline; Espay, Alberto J; Wright, Anthony P; El Andaloussi, Samir; Lindén, Anders; Ezzat, Kariem. Frontiers in neuroscience 14: 256. 2020
Does Cholinergic Stimulation Affect the P2X7 Receptor-Mediated Dye Uptake in Mast Cells and Macrophages?
Nurkhametova, Dilyara; Siniavin, Andrei; Streltsova, Maria; Kudryavtsev, Denis; Kudryavtsev, Igor; Giniatullina, Raisa; Tsetlin, Victor; Malm, Tarja; Giniatullin, Rashid. Frontiers in cellular neuroscience 14: 548376. 2020
Editorial: Air Pollution and Brain Health
White, Anthony; Kanninen, Katja; Malm, Tarja; Schins, Roel. Neurochemistry international 141: 104900. 2020
The viral protein corona directs viral pathogenesis and amyloid aggregation
Ezzat, K; Pernemalm, M; Pålsson, S; Roberts, TC; Järver, P; Dondalska, A; Bestas, B; Sobkowiak, MJ; Levänen, B; Sköld, M; Thompson, EA; Saher, O; Kari, OK; Lajunen, T; Sverremark Ekström, E; Nilsson, C; Ishchenko, Y; Malm, T; Wood, MJA; Power, UF; et al.. Nature communications 10 1: 2331. 2019
Peripheral inflammatory markers and clinical correlations in patients with frontotemporal lobar degeneration with and without the C9orf72 repeat expansion
Katisko, K; Solje, E; Korhonen, P; Jääskeläinen, O; Loppi, S; Hartikainen, P; Koivisto, AM; Kontkanen, A; Korhonen, VE; Helisalmi, S; Malm, T; Herukka, SK; Remes, AM; Haapasalo, A. Journal of neurology 2020; 267: 76-86. 2019
Peripheral Administration of IL-13 Induces Anti-inflammatory Microglial/Macrophage Responses and Provides Neuroprotection in Ischemic Stroke
Kolosowska, N; Keuters, MH; Wojciechowski, S; Keksa-Goldsteine, V; Laine, M; Malm, T; Goldsteins, G; Koistinaho, J; Dhungana, H. Neurotherapeutics 16: 1304-1319. 2019
PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia
Konttinen, H; Cabral-da-Silva, MEC; Ohtonen, S; Wojciechowski, S; Shakirzyanova, A; Caligola, S; Giugno, R; Ishchenko, Y; Hernández, D; Fazaludeen, MF; Eamen, S; Budia, MG; Fagerlund, I; Scoyni, F; Korhonen, P; Huber, N; Haapasalo, A; Hewitt, AW; Vickers, J; Smith, GC; et al.. Stem cell reports 13 4: 669-683. 2019
Long-term interleukin-33 treatment delays disease onset and alleviates astrocytic activation in a transgenic mouse model of amyotrophic lateral sclerosis
Korhonen, P; Pollari, E; Kanninen, KM; Savchenko, E; Lehtonen, Š; Wojciechowski; S; Pomeshchik, Y; Van Den Bosch, L; Goldsteins, G; Koistinaho, J; Malm, T. IBRO Reports 6: 74-86. 2019
Meningeal Mast Cells Contribute to ATP-Induced Nociceptive Firing in Trigeminal Nerve Terminals: Direct and Indirect Purinergic Mechanisms Triggering Migraine Pain
Koroleva, Ksenia; Gafurov, Oleg; Guselnikova, Valeriia; Nurkhametovez, Dilyara; Giniatullina, Raisa; Sitdikova, Guzel; Mattila, Olli S; Lindsberg, Perttu J; Malm, Tarja Maarit; Giniatullin, Rashid. Frontiers in cellular neuroscience 13: 195. 2019
Mechanosensitive meningeal nociception via Piezo channels: Implications for pulsatile pain in migraine?
Mikhailov, N; Leskinen, J; Fagerlund, I; Poguzhelskaya, E; Giniatullina, R; Gafurov, O; Malm, T; Karjalainen, T; Gröhn, O; Giniatullin, R. Neuropharmacology 149: 113-123. 2019
Activation of P2X7 Receptors in Peritoneal and Meningeal Mast Cells Detected by Uptake of Organic Dyes: Possible Purinergic Triggers of Neuroinflammation in Meninges
Nurkhametova, Dilyara; Kudryavtsev, Igor; Guselnikova, Valeriia; Serebryakova, Maria; Giniatullina, Raisa R; Wojciechowski, Sara; Tore, Fatma; Rizvanov, Albert; Koistinaho, Jari; Malm, Tarja; Giniatullin, Rashid. Frontiers in cellular neuroscience 13: 45. 2019
Loss of Cln5 leads to altered Gad1 expression and deficits in interneuron development in mice
Singh, Y; Leinonen, H; Fazaludeen, F; Jaronen, M; Guest, D; Buckley, N; Byts, N; Oksa, P; Jalkanen, K; Iqbal, I; Huuskonen, M; Savchenko, E; Keksa-Goldsteine, V; Chew, S; Myllyharju, J; Tanila, H; Ooi, L; Koistinaho, J; Kanninen, KM; Malm, T. Human molecular genetics 28 11: 3309-3322. 2019
Changes in nuclear and cytoplasmic microRNA distribution in response to hypoxic stress
Turunen, TA; Roberts, TC; Laitinen, P; Väänänen, MA; Korhonen, P; Malm, T; Ylä-Herttuala, S; Turunen, M. Scientific reports 9: 10332. 2019
8th Kuopio Alzheimer Symposium From translational research to biomarkers, treatment and prevention strategies
Malm, Tarja; Trevisan, Davide. 2018 2018
Targeting Nrf2 to Suppress Ferroptosis and Mitochondrial Dysfunction in Neurodegeneration
Abdalkader, Moataz; Lampinen, Riikka; Kanninen, Katja M; Malm, Tarja M; Liddell, Jeffrey R. Frontiers in Neuroscience 12: 466. 2018
Sushi repeat-containing protein X-Linked 2 - a novel phylogenetically conserved hypothalamo-pituitary protein
Anwer, M; Bolkvadze, T; Ndode-Ekane, XE; Puhakka, N; Rauramaa, T; Leinonen, V; van Vliet, EA; Swaab, DF; Haapasalo, A; Leskelä, S; Bister, N; Malm, T; Carlson, S; Aronica, E; Pitkänen, A. JOURNAL OF COMPARATIVE NEUROLOGY 526 11: 1806-1819. 2018
CuII(atsm) Attenuates Neuroinflammation
Choo, Xin Yi; Liddell, Jeffrey R; Huuskonen, Mikko T; Grubman, Alexandra; Moujalled, Diane; Roberts, Jessica; Kysenius, Kai; Patten, Lauren; Quek, Hazel; Oikari, Lotta E; Duncan, Clare; James, Simon A; McInnes, Lachlan E; Hayne, David J; Donnelly, Paul S; Pollari, Eveliina; Vähätalo, Suvi; Lejavová, Katarína; Kettunen, Mikko I; Malm, Tarja; et al. [Incl Koistinaho, Jari; Kanninen, Katja]. Frontiers in neuroscience 12: 668. 2018
PPARß/DELTA-agonist GW0742 ameliorates dysfunction in fatty acid oxidation in PSEN1deltaE9 astrocytes
Konttinen, H; Gureviciene, I; Oksanen, M; Grubman, A; Loppi, S; Huuskonen, MT; Korhonen, P; Lampinen, R; Keuters, M; Belaya, I; Tanila, H; Kanninen, KM; Goldsteins, G; Landreth, G; Koistinaho, J; Malm, T. GLIA 2019; 67 1: 146-159. 2018
3D human brain cell models: New frontiers in disease understanding and drug discovery for neurodegenerative diseases
Korhonen, Paula; Malm, Tarja; White, Anthony R. NEUROCHEMISTRY INTERNATIONAL 120: 191-199. 2018
HX600, a synthetic agonist for RXR-Nurr1 heterodimer complex, prevents ischemia-induced neuronal damage
Loppi, S; Kolosowska, N; Kärkkäinen, O; Korhonen, P; Huuskonen, M; Grubman, A; Dhungana, H; Wojciechowski, S; Pomeshchik, Y; Giordano, M; Kagechika, H; White, A; Auriola, S; Koistinaho, J; Landreth, G; Hanhineva, K; Kanninen, K; Malm, T. Brain, behavior, and immunity 73: 670-681. 2018
Mitochondrial Function in Alzheimer's Disease: Focus on Astrocytes
Lampinen, Riikka; Belaya, Irina; Boccuni, Isabella; Malm, Tarja; Kanninen, Katja M / Astrocyte: Physiology and Pathology. 2018. 2018
Genotyping and Frequency of PCSK9 Variations Among Hypercholesterolemic and Diabetic Subjects
Nuglozeh, Edem; Feroze Fazaludeen, Mohammad; Hasona, Nabil; Malm, Tarja; Mayor, Luisito B; Al-Hazmi, Awdah; Ashankyty, Ibraheem. Indian Journal of Clinical Biochemistry 2019; 34 4: 444-450. 2018
Purinergic Profiling of Regulatory T-cells in Patients With Episodic Migraine
Nurkhametova, Dilyara; Kudryavtsev, Igor; Khayrutdinova, Olga; Serebryakova, Maria; Altunbaev, Rashid; Malm, Tarja; Giniatullin, Rashid. Frontiers in cellular neuroscience 12: 326. 2018
Sulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke-induced neuroinflammation
Dhungana H, Huuskonen MT, Jaronen M, Lemarchant S, Ali H, Keksa-Goldsteine V, Goldsteins G, Kanninen KM, Koistinaho J, Malm T. JOURNAL OF NEUROINFLAMMATION [HTTP://WWW.JNEUROINFLAMMATION.COM/] 14 11: 237. 2017
Lack of collagen XV is protective after ischemic stroke in mice
Dhungana Hiramani, Huuskonen Mikko T, Pihlajaniemi Taina, Heljasvaara Ritva, Vivien Denis, Kanninen Katja M, Malm Tarja, Koistinaho Jari, Lemarchant Sighild. Cell Death and Disease 8 January: 1-8. 2017
Augmentation of Anticancer Drug Efficacy in Murine Hepatocellular Carcinoma Cells by a Peripherally Acting Competitive N-Methyl-d-aspartate (NMDA) Receptor Antagonist
Gynther M, Proietti Silvestri I, Hansen JC, Hansen KB, Malm T, Ishchenko Y, Larsen Y, Han L, Kayser S, Auriola S, Petsalo A, Nielsen B, Pickering DS, Bunch L. JOURNAL OF MEDICINAL CHEMISTRY 60 23: 9885-9904. 2017
The Copper bis(thiosemicarbazone) Complex Cu(II)(atsm) Is Protective Against Cerebral Ischemia Through Modulation of the Inflammatory Milieu
Huuskonen, MT; Tuo, QZ; Loppi, S; Dhungana, H; Korhonen, P; McInnes, LE; Donnelly, PS; Grubman, A; Wojciechowski, S; Lejavova, K; Pomeshchik, Y; Periviita, L; Kosonen, L; Giordano, M; Walker, FR; Liu, R; Bush, AI; Koistinaho, J; Malm, T; White, AR; et al.. NEUROTHERAPEUTICS 14 2: 519-532. 2017
Metals and lysosomal storage disorders
Konttinen Henna, Lejavová Katarína, Malm Tarja, Kanninen Katja M. Teoksessa: White Anthony R, Aschner Michael, Costa Lucio G, Bush Ashley I (toim.) Biometals in neurodegenerative diseases : mechanisms and therapeutics. Academic press. s. 195-215. 2017
Retinal Degeneration In A Mouse Model Of CLN5 Disease Is Associated With Compromised Autophagy
Leinonen Henri, Keksa-Goldsteine Velta, Ragauskas Symantas, Kohlmann Philip, Signh Yajuvinder, Savchencko Ekaterina, Puranen Jooseppi, Malm Tarja, Kalesnykas Giedrius, Koistinaho Jari, Tanila Heikki, Kanninen Katja M. Scientific Reports 7: 1597. 2017
Neuronally-directed effects of RXR activation in a mouse model of Alzheimer's disease
Mariani MM, Malm T, Lamb R, Jay TR, Neilson L, Casali B, Medarametla L, Landreth GE. Scientific Reports 7: 42270. 2017
DHCR24 exerts neuroprotection upon inflammation-induced neuronal death
Martiskainen H, Paldanius KMA, Natunen T, Takalo M, Marttinen M, Leskelä S, Huber N, Mäkinen P, Bertling E, Dhungana H, Huuskonen M, Honkakoski P, Hotulainen P, Rilla K, Koistinaho J, Soininen H, Malm T, Haapasalo A, Hiltunen M. JOURNAL OF NEUROINFLAMMATION [HTTP://WWW.JNEUROINFLAMMATION.COM/] 14: 215. 2017
Disease-modifying effect of atipamezole in a model of post-traumatic epilepsy
Nissinen J, Andrade P, Natunen T, Hiltunen M, Malm T, Kanninen K, Soares JI, Shatilloa O, Sallinen J, Ndode-Ekanea XE, Pitkänen A. EPILEPSY RESEARCH 136: 18-34. 2017
Psychosocial stress on neuroinflammation and cognitive dysfunctions in Alzheimer's diseasethe emerging role for microglia?
Piirainen S, Youssef A, Song C, Kalueff AV, Landreth GE, Malm T, Tian L. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS 77: 148-164. 2017
Loss of CLN5 causes altered neurogenesis in a childhood neurodegenerative disorder
Savchenko E, Singh Y, Konttinen H, Lejavova K, Mediavilla Santos L, Grubman A, Kärkkäinen V, Keksa-Goldsteine V, Naumenko N, Tavi P, White AR, Malm TM, Koistinaho J, Kanninen KM. Disease models & mechanisms 10 9: 1089-1100. 2017
Disease-Induced Alterations in Brain Drug Transporters in Animal Models of Alzheimer's Disease
Vellonen KS, Ihalainen J, Boucau M-C, Gosselet F, Picardat T, Gynther M, Kanninen KM, White AR, Malm T, Koistinaho J, Forsberg MM, Ruponen M. PHARMACEUTICAL RESEARCH 34 12: 2652-2662. 2017
Pro-nociceptive migraine mediator CGRP provides neuroprotection of sensory, cortical and cerebellar neurons via multi-kinase signaling
Abushik PA, Bart G, Korhonen P, Leinonen H, Giniatullina R, Sibarov DA, Levonen A-L , Malm T, Antonov SM, Giniatullin R. Cephalalgia 2017; 37 14: 1373-1383. 2016
Multitasking Microglia and Alzheimer's Disease: Diversity, Tools and Therapeutic Targets
Grubman Alexandra, Kanninen Katja M, Malm Tarja. JOURNAL OF MOLECULAR NEUROSCIENCE 60 3: 390-404. 2016
Bexarotene targets autophagy and is protective against thromboembolic stroke in aged mice with tauopathy
Huuskonen MT, Loppi S, Dhungana H, Keksa-Goldsteine V, Lemarchant S, Korhonen P, Wojciechowski S, Pollari E, Valonen P, Koponen J, Takashima A, Landreth G, Goldsteins G, Malm T, Koistinaho J, Kanninen KM. Scientific Reports 6: 33176. 2016
Eksosomit aivosairauksissa - solujenvälisen kommunikoinnin uusi muoto
Kanninen K, Malm T. DUODECIM 132 21: 1957-63. 2016
Anti-inflammatory effects of ADAMTS-4 in a mouse model of ischemic stroke
Lemarchant S, Dunghana H, Pomeshchik Y, Leinonen H, Kolosowska N, Korhonen P, Kanninen KM, García-Berrocoso T, Montaner J, Malm T, Koistinaho J. Glia 64 9: 1492-507. 2016
ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis
Lemarchant S, Pomeshchik Y, Kidin I, Kärkkäinen V, Valonen P, Lehtonen S, Goldsteins G, Malm T, Kanninen K, Koistinaho J. MOLECULAR NEURODEGENERATION 11: 10. 2016
Erratum to: ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis
Lemarchant S, Pomeshchik Y, Kidin I, Kärkkäinen V, Valonen P, Lehtonen S, Goldsteins G, Malm T, Kanninen K, Koistinaho J. MOLECULAR NEURODEGENERATION 11: 15. 2016
Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes
Liddell Jeffrey R, Lehtonen Sarka, Duncan Clare, Keksa-Goldsteine Velta, Levonen Anna-Liisa, Goldsteins Gundars, Malm Tarja, White Anthony R, Koistinaho Jari, Kanninen Katja M. JOURNAL OF NEUROINFLAMMATION [HTTP://WWW.JNEUROINFLAMMATION.COM/] 13 49: 1-14. 2016
Exosomes in Alzheimer's disease
Malm Tarja, Loppi Sanna, Kanninen Katja M. NEUROCHEMISTRY INTERNATIONAL 97: 193-199. 2016
Aß and Inflammatory Stimulus Activate Diverse Signaling Pathways in Monocytic Cells: Implications in Retaining Phagocytosis in Aß-Laden Environment
Savchenko Ekaterina, Malm Tarja, Konttinen Henna, Hämäläinen Riikka H, Guerrero-Toro Cindy, Wojciechowski Sara, Giniatullin Rashid, Koistinaho Jari, Magga Johanna. Frontiers in Cellular Neuroscience 10: 279. 2016
Exosomes as new diagnostic tools in CNS diseases
Kanninen Katja M, Bister Nea, Koistinaho Jari, Malm Tarja. BIOCHIMICA ET BIOPHYSICA ACTA - MOLECULAR BASIS OF DISEASE 2016; 1862 3: 403-410. 2015
Applications of the Keap1-Nrf2 system for gene and cell therapy
Kanninen Katja M, Pomeshchik Yuriy, Leinonen Hanna, Malm Tarja, Koistinaho Jari, Levonen Anna-Liisa. FREE RADICAL BIOLOGY & MEDICINE 88 Part B: 350-361. 2015
Immunomodulation by interleukin-33 is protective in stroke through modulation of inflammation
Korhonen Paula, Kanninen Katja M, Lehtonen Sarka, Lemarchant Sighild, Puttonen Katja A, Oksanen Minna, Dhungana Hiramani, Loppi Sanna, Pollari Eveliina, Wojciechowski Sara, Kidin Iurii, Garcia-Berrocoso Teresa, Giralt Dolors, Montaner Joan, Koistinaho Jan I, Malm Tarja. Brain, behavior, and immunity 49: 322-336. 2015
Activation of the nuclear receptor PPARdelta is neuroprotective in a transgenic mouse model of Alzheimer's disease through inhibition of inflammation
Malm Tarja, Mariani Monica, Donovan Lauren J, Neilson Lee, Landreth Gary E. JOURNAL OF NEUROINFLAMMATION [HTTP://WWW.JNEUROINFLAMMATION.COM/] 12 7: 15 p. 2015
A cross-laboratory preclinical study on the effectiveness of interleukin-1 receptor antagonist in stroke
Maysami Samaneh, Wong Raymond, Pradillo Jesus M, Denes Adam, Dhungana Hiramani, Malm Tarja, Koistinaho Jari, Orset Cyrille, Rahman Mahbubur, Rubio Marina, Schwaninger Markus, Vivien Denis, Bath Philip M, Rothwell Nancy J, Allan Stuart M. Journal of Cerebral Blood Flow & Metabolism [epub ahead of print Sep 30, 2015]: -. 2015
Deletion of Nuclear Factor kappa B p50 Subunit Decreases Inflammatory Response and Mildly Protects Neurons from Transient Forebrain Ischemia-induced Damage
Rolova Taisia, Dhungana Hiramani, Korhonen Paula, Valonen Piia, Kolosowska Natalia, Konttinen Henna, Kanninen Katja, Tanila Heikki, Malm Tarja, Koistinaho Jari. Aging and disease [epub ahead of print 3 Dec 2015]: -. 2015
Nuclear receptors license phagocytosis by trem2+ myeloid cells in mouse models of Alzheimer's disease
Savage Julie C, Jay Taylor, Goduni Elanda, Quigley Caitlin, Mariani Monica M, Malm Tarja, Ransohoff Richard M, Lamb Bruce T, Landreth Gary E. JOURNAL OF NEUROSCIENCE 35 16: 6532-6543. 2015
Susceptibility to focal and global brain ischemia of Alzheimer mice displaying aß deposits: effect of immunoglobulin
Heikkinen Riikka, Malm Tarja, Heikkilä Janne, Muona Anu, Tanila Heikki, Koistinaho Milla, Koistinaho Jari. Aging and disease 2014 Apr 1;5(2): 76-87. 2014
Nrf2 regulates neurogenesis and protects neural progenitor cells against aß toxicity
Kärkkäinen Virve, Pomeshchik Yuriy, Savchenko Ekaterina, Dhungana Hiramani, Kurronen Antti, Lehtonen Sarka, Naumenko Nikolay, Tavi Pasi, Levonen Anna-Liisa, Yamamoto Masayaki, Malm Tarja, Magga Johanna, Kanninen Katja M, Koistinaho Jari. STEM CELLS 32 7: 1904-1916. 2014
The Evolving Biology of Microglia in Alzheimer's Disease
Malm Tarja M, Jay Taylor R, Landreth Gary E. NEUROTHERAPEUTICS - 2014 Nov 18. [Epub ahead of print]: -. 2014
Interleukin-33 treatment reduces secondary injury and improves functional recovery after contusion spinal cord injury
Pomeshchik Y, Kidin I, Korhonen P, Savchenko E, Jaronen M, Lehtonen S, Wojciechowski S, Kanninen K, Koistinaho J, Malm T. Brain, behavior, and immunity 2014 Aug 18 ePub ahead of print: --. 2014
Transplanted human iPSC-derived neural progenitor cells do not promote functional recovery of pharmacologically immunosuppressed mice with contusion spinal cord injury
Pomeshchik Y, Puttonen KA, Kidin I, Ruponen M, Lehtonen S, Malm T, Akesson E, Hovatta O, Koistinaho J. Cell Transplantation 2014 Sep 8. [Epub ahead of print]: - -. 2014
Nuclear receptors in neurodegenerative diseases
Skerrett R, Malm T, Landreth G. NEUROBIOLOGY OF DISEASE (SAN DIEGO CA) 72 Part A: 104-116. 2014
Aging aggravates ischemic stroke-induced brain damage in mice with chronic peripheral infection
Dhungana H, Malm T, Denes A, Valonen P, Wojciechowski S, Magga J, Savchenko E, Humphreys N, Grencis R, Rothwell N, Koistinaho J. Aging cell 2013 Jun 3. (Epub ahead of print): --. 2013
Western-type diet modulates inflammatory responses and impairs functional outcome following permanent middle cerebral artery occlusion in aged mice expressing the human apolipoprotein E4 allele
Dhungana H, Rolova T, Savchenko E, Wojciechowski S, Savolainen K, Ruotsalainen AK, Sullivan PM, Koistinaho J, Malm T. JOURNAL OF NEUROINFLAMMATION [HTTP://WWW.JNEUROINFLAMMATION.COM/] 2013 Aug 20;10(1):102: --. 2013
Does Nrf2 Gene Transfer Facilitate Recovery After Contusion Spinal Cord Injury?
Pomeshchik Y, Kidin I, Savchenko E, Rolova T, Yamamoto M, Levonen AL, Ylä-Herttuala S, Malm T, Kanninen K, Koistinaho J. ANTIOXIDANTS AND REDOX SIGNALING 2013 Aug 20. [Epub ahead of print]: x-x. 2013
Complex regulation of acute and chronic neuroinflammatory responses in mouse models deficient for nuclear factor kappa B p50 subunit
Rolova T, Puli L, Magga J, Dhungana H, Kanninen K, Wojciehowski S, Salminen A, Tanila H, Koistinaho J, Malm T. NEUROBIOLOGY OF DISEASE (SAN DIEGO CA) [Epub ahead of print] 64C: 16-29. 2013
Protein Disulfide Isomerase in ALS Mouse Glia Links Protein Misfolding with NADPH Oxidase Catalyzed Superoxide Production
Jaronen M, Vehviläinen P, Malm T, Keksa-Goldsteine V, Pollari E, Valonen P, Koistinaho J, Goldsteins G. HUMAN MOLECULAR GENETICS 2012 Nov 1. [Epub ahead of print]: - -. 2012
Brain Environment and Alzheimer's Disease Mutations Affect the Survival, Migration and Differentiation of Neural Progenitor Cells
Kärkkäinen V, Magga J, Koistinaho J, Malm T. CURRENT ALZHEIMER RESEARCH 2012 Aug 30. [Epub ahead of print]: --. 2012
Production of monocytic cells from bone marrow stem cells: therapeutic usage in Alzheimer's disease
Magga J, Savchenko E, Malm T, Rolova T, Pollari E, Valonen P, Lehtonen S, Jantunen E, Aarnio J, Lehenkari P, Koistinaho M, Muona A, Koistinaho J. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 2012 May;16(5): 1060-73. 2012
Animal Models of Alzheimer's Disease: Utilization of Transgenic Alzheimer's Disease Models in Studies of Amyloid Beta Clearance
Malm T, Magga J, Koistinaho J. Current Translational Geriatrics and Gerontology Reports - -: - -. 2012
Effects of human intravenous immunoglobulin on amyloid pathology and neuroinflammation in a mouse model of Alzheimer's disease
Puli L, Pomeshchik Y, Olas K, Malm T, Koistinaho J, Tanila H. JOURNAL OF NEUROINFLAMMATION [HTTP://WWW.JNEUROINFLAMMATION.COM/] 2012 May 29;9:105: - -. 2012
Targeting Glycogen Synthase Kinase-3&#946 for Therapeutic Benefit against Oxidative Stress in Alzheimer's Disease: Involvement of the Nrf2-ARE Pathway
Kanninen K, White AR, Koistinaho J, Malm T. 2011. Targeting Glycogen Synthase Kinase-3β for Therapeutic Benefit against Oxidative Stress in Alzheimer's Disease: Involvement of the Nrf2-ARE Pathway International Journal of Alzheimer's Disease 2011;2011:985085. Epub 2011 May 2: --. 2011
Glycogen synthase kinase-3&#946 : a mediator of inflammation in Alzheimer's disease?
Koistinaho J, Malm T, Goldsteins G. 2011. Glycogen synthase kinase-3β: a mediator of inflammation in Alzheimer's disease? International Journal of Alzheimer's Disease 2011;2011:129753. Epub 2011 May 4: --. 2011
Utilization of APPswe/PS1dE9 Transgenic Mice in Research of Alzheimer's Disease: Focus on Gene Therapy and Cell-Based Therapy Applications
Malm T, Koistinaho J, Kanninen K. International Journal of Alzheimer's Disease 2011;2011:517160. Epub 2011 Oct 30: --. 2011
Granulocyte colony stimulating factor attenuates inflammation in a mouse model of amyotrophic lateral sclerosis
Pollari Eveliina, Savchenko Ekaterina, Jaronen Merja, Kanninen Katja, Malm Tarja, Wojciechowski Sara, Ahtoniemi Toni, Goldsteins Gundars, Giniatullina Raisa, Giniatullin Rashid, Koistinaho Jari, Magga Johanna. JOURNAL OF NEUROINFLAMMATION [HTTP://WWW.JNEUROINFLAMMATION.COM/] 84: 1-14. 2011
Human intravenous immunoglobulin provides protection against A&#946 toxicity by multiple mechanisms in a mouse model of Alzheimer's disease
Magga J, Puli L, Pihlaja R, Kanninen K, Neulamaa S, Malm T, Härtig W, Grosche J, Goldsteins G, Tanila H et al. 2010. Human intravenous immunoglobulin provides protection against Aβ toxicity by multiple mechanisms in a mouse model of Alzheimer's disease. JOURNAL OF NEUROINFLAMMATION [HTTP://WWW.JNEUROINFLAMMATION.COM/] 7: 90. 2010
The role and therapeutic potential of monocytic cells in Alzheimer's disease
Malm T, Koistinaho M, Muona A, Magga J & Koistinaho J. GLIA 58 8: 889-900. 2010
Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease
Kanninen K, Heikkinen R, Malm T, Rolova T, Kuhmonen S, Leinonen H, Ylä-Herttuala S, Tanila H, Levonen AL, Koistinaho M, Koistinaho J. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106 38: 16505-16510. 2009
Nuclear factor erythroid 2-related factor 2 protects against beta amyloid
Kanninen K, Malm TM, Jyrkkänen HK, Goldsteins G, Keksa-Goldsteine V, Tanila H, Yamamoto M, Ylä-Herttuala S, Levonen AL, Koistinaho J. MOLECULAR AND CELLULAR NEUROSCIENCE (SAN DIEGO CA) 39 3: 302-313. 2008
Age-related decrease in stimulated glutamate release and vesicular glutamate transporters in APP/PS1 transgenic and wild-type mice
Minkeviciene R, Ihalainen J, Malm T, Matilainen O, Keksa-Goldsteine V, Goldsteins G, Iivonen H, Leguit N, Glennon J, Koistinaho J, Banerjee P, Tanila H. JOURNAL OF NEUROCHEMISTRY 105: 584-594. 2008
Transplanted astrocytes internalize deposited beta-amyloid peptides in a transgenic mouse model of Alzheimer's disease
Pihlaja R, Koistinaho J, Malm T, Sikkilä H, Vainio S, Koistinaho M. GLIA 56: 154-163. 2008
Hypoxia induces microRNA miR-210 in vitro and in vivo ephrin-A3 and neuronal pentraxin 1 are potentially regulated by miR-210
Pulkkinen K, Malm T, Turunen M, Koistinaho J, Ylä-Herttuala S. FEBS LETTERS 582: 2397-2401. 2008
Pyrrolidine dithiocarbamate inhibits induction of immunoproteasome and decreases survival in a rat model of amyotrophic lateral sclerosis
Ahtoniemi T, Goldsteins G, Keksa-Goldsteine V, Malm T, Kanninen K, Salminen A, Koistinaho J. MOLECULAR PHARMACOLOGY 71: 30-37. 2007
Pyrrolidine dithiocarbamate activates akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden
Malm TM, Iivonen H, Goldsteins G, Keksa-Goldsteine V, Ahtoniemi T, Kanninen K, Salminen A, Auriola S, van Groen T, Tanila H, Koistinaho J. JOURNAL OF NEUROSCIENCE 27 14: 3712-3721. 2007
Beta-amyloid infusion results in delayed and age-dependent learning deficits without role of inflammation or beta-amyloid deposits
Malm T, Ort M, Tähtivaara L, Jukarainen N, Goldsteins G, Puoliväli J, Nurmi A, Pussinen R, Ahtoniemi T, Miettinen T-K, Kanninen K, Leskinen S, Vartiainen N, Yrjänheikki J, Laatikainen R, Harris-White ME, Koistinaho M, Frautschy SA, Bures J. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 103 23: 8852-8857. 2006
Glial Cells in Alzheimer's Disease Models
Malm T. Kuopion yliopiston julkaisuja G.- A.I. Virtanen -instituutti. 2006
Stable RNA interference: comparison of U6 and H1 promoters in endothelial cells and in mouse brain
Mäkinen PI, Koponen JK, Kärkkäinen A-M, Malm TM, Pulkkinen KH, Koistinaho J, Turunen MP, Ylä-Herttuala S. JOURNAL OF GENE MEDICINE 8 4: 433-441. 2006
Minocycline protects against permanent cerebral ischemia in wild type but not in matrix metalloprotease-9-deficient mice
Koistinaho M, Malm TM, Kettunen MI, Goldsteins G, Starckx S, Kauppinen RA, Opdenakker G, Koistinaho J. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 25: 460-467. 2005
Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to beta-amyloid deposition in APP/PS1 double transgenic Alzheimer mice
Malm TM, Koistinaho M, Pärepalo M, Vatanen T, Ooka A, Karlsson S, Koistinaho J. NEUROBIOLOGY OF DISEASE (SAN DIEGO CA) 18 1: 134-142. 2005

University of Eastern Finland Joensuu, Kuopio © University of Eastern Finland

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Näytä asetukset

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Tarja Malm

Tutkimusryhmät

Projektit

Avainsanat

Additive Behavioral Improvement after Combined Cell Therapy and Rehabilitation Despite Long-Term Microglia Presence in Stroke Rats

Regular Physical Exercise Modulates Iron Homeostasis in the 5xFAD Mouse Model of Alzheimer's Disease

"Time window" effect of Yoda1-evoked Piezo1 channel activity during mouse skeletal muscle differentiation

Microglia-like Cells Promote Neuronal Functions in Cerebral Organoids

Systemic cross-talk between brain, gut, and peripheral tissues in glucose homeostasis: effects of exercise training (CROSSYS). Exercise training intervention in monozygotic twins discordant for body weight

Extracellular Vesicles from Human Teeth Stem Cells Trigger ATP Release and Promote Migration of Human Microglia through P2X4 Receptor/MFG-E8-Dependent Mechanisms

An arylthiazyne derivative is a potent inhibitor of lipid peroxidation and ferroptosis providing neuroprotection in vitro and in vivo

Alzheimerin taudin uudet riskigeenit - keskiössä mikrogliasolut

Functional Characterization of Human Pluripotent Stem Cell-Derived Models of the Brain with Microelectrode Arrays

Glia-Derived Extracellular Vesicles: Role in Central Nervous System Communication in Health and Disease

Systemic inflammation induced changes in protein expression of ABC transporters and ionotropic glutamate receptor subunit 1 in the cerebral cortex of familial Alzheimer`s disease mouse model

Metabolomic and lipidomic changes triggered by lipopolysaccharide-induced systemic inflammation in transgenic APdE9 mice

High cerebrospinal amyloid-β 42 is associated with normal cognition in individuals with brain amyloidosis

Microglia Development and Maturation and Its Implications for Induction of Microglia-Like Cells from Human iPSCs

Astrocyte remodeling in the beneficial effects of long-term voluntary exercise in Alzheimer's disease

Hypoxia and extracellular vesicles: A review on methods, vesicular cargo and functions

Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-ß from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy

Impairment of mitochondrial function by particulate matter: Implications for the brain

Urban air particulate matter induces mitochondrial dysfunction in human olfactory mucosal cells

Glial smog: Interplay between air pollution and astrocyte-microglia interactions

Intracerebral overexpression of miR-669c is protective in mouse ischemic stroke model by targeting MyD88 and inducing alternative microglial/macrophage activation

Peripheral inflammation preceeding ischemia impairs neuronal survival through mechanisms involving miR-127 in aged animals

Disentangling the Amyloid Pathways: A Mechanistic Approach to Etiology

Does Cholinergic Stimulation Affect the P2X7 Receptor-Mediated Dye Uptake in Mast Cells and Macrophages?

Editorial: Air Pollution and Brain Health

The viral protein corona directs viral pathogenesis and amyloid aggregation

Peripheral inflammatory markers and clinical correlations in patients with frontotemporal lobar degeneration with and without the C9orf72 repeat expansion

Peripheral Administration of IL-13 Induces Anti-inflammatory Microglial/Macrophage Responses and Provides Neuroprotection in Ischemic Stroke

PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia

Long-term interleukin-33 treatment delays disease onset and alleviates astrocytic activation in a transgenic mouse model of amyotrophic lateral sclerosis

Meningeal Mast Cells Contribute to ATP-Induced Nociceptive Firing in Trigeminal Nerve Terminals: Direct and Indirect Purinergic Mechanisms Triggering Migraine Pain

Mechanosensitive meningeal nociception via Piezo channels: Implications for pulsatile pain in migraine?

Activation of P2X7 Receptors in Peritoneal and Meningeal Mast Cells Detected by Uptake of Organic Dyes: Possible Purinergic Triggers of Neuroinflammation in Meninges

Loss of Cln5 leads to altered Gad1 expression and deficits in interneuron development in mice

Changes in nuclear and cytoplasmic microRNA distribution in response to hypoxic stress

8th Kuopio Alzheimer Symposium From translational research to biomarkers, treatment and prevention strategies

Targeting Nrf2 to Suppress Ferroptosis and Mitochondrial Dysfunction in Neurodegeneration

Sushi repeat-containing protein X-Linked 2 - a novel phylogenetically conserved hypothalamo-pituitary protein

CuII(atsm) Attenuates Neuroinflammation

PPARß/DELTA-agonist GW0742 ameliorates dysfunction in fatty acid oxidation in PSEN1deltaE9 astrocytes

3D human brain cell models: New frontiers in disease understanding and drug discovery for neurodegenerative diseases

HX600, a synthetic agonist for RXR-Nurr1 heterodimer complex, prevents ischemia-induced neuronal damage

Mitochondrial Function in Alzheimer's Disease: Focus on Astrocytes

Genotyping and Frequency of PCSK9 Variations Among Hypercholesterolemic and Diabetic Subjects

Purinergic Profiling of Regulatory T-cells in Patients With Episodic Migraine

Sulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke-induced neuroinflammation

Lack of collagen XV is protective after ischemic stroke in mice

Augmentation of Anticancer Drug Efficacy in Murine Hepatocellular Carcinoma Cells by a Peripherally Acting Competitive N-Methyl-d-aspartate (NMDA) Receptor Antagonist

The Copper bis(thiosemicarbazone) Complex Cu(II)(atsm) Is Protective Against Cerebral Ischemia Through Modulation of the Inflammatory Milieu

Metals and lysosomal storage disorders

Retinal Degeneration In A Mouse Model Of CLN5 Disease Is Associated With Compromised Autophagy

Neuronally-directed effects of RXR activation in a mouse model of Alzheimer's disease

DHCR24 exerts neuroprotection upon inflammation-induced neuronal death

Disease-modifying effect of atipamezole in a model of post-traumatic epilepsy

Psychosocial stress on neuroinflammation and cognitive dysfunctions in Alzheimer's diseasethe emerging role for microglia?

Loss of CLN5 causes altered neurogenesis in a childhood neurodegenerative disorder

Disease-Induced Alterations in Brain Drug Transporters in Animal Models of Alzheimer's Disease

Pro-nociceptive migraine mediator CGRP provides neuroprotection of sensory, cortical and cerebellar neurons via multi-kinase signaling

Multitasking Microglia and Alzheimer's Disease: Diversity, Tools and Therapeutic Targets

Bexarotene targets autophagy and is protective against thromboembolic stroke in aged mice with tauopathy

Eksosomit aivosairauksissa - solujenvälisen kommunikoinnin uusi muoto

Anti-inflammatory effects of ADAMTS-4 in a mouse model of ischemic stroke

ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis

Erratum to: ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis

Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes

Exosomes in Alzheimer's disease

Aß and Inflammatory Stimulus Activate Diverse Signaling Pathways in Monocytic Cells: Implications in Retaining Phagocytosis in Aß-Laden Environment

Exosomes as new diagnostic tools in CNS diseases

Applications of the Keap1-Nrf2 system for gene and cell therapy

Immunomodulation by interleukin-33 is protective in stroke through modulation of inflammation

Activation of the nuclear receptor PPARdelta is neuroprotective in a transgenic mouse model of Alzheimer's disease through inhibition of inflammation

A cross-laboratory preclinical study on the effectiveness of interleukin-1 receptor antagonist in stroke

Deletion of Nuclear Factor kappa B p50 Subunit Decreases Inflammatory Response and Mildly Protects Neurons from Transient Forebrain Ischemia-induced Damage

Nuclear receptors license phagocytosis by trem2+ myeloid cells in mouse models of Alzheimer's disease

Susceptibility to focal and global brain ischemia of Alzheimer mice displaying aß deposits: effect of immunoglobulin

Nrf2 regulates neurogenesis and protects neural progenitor cells against aß toxicity