TIINA JääSKELäINEN

Yhteystiedot

Avainsanat

Tutkimusryhmät - UEF

• 
  Steroidireseptorit ja SUMO-muokkaukset geenien luennan ja solujen erilaistumisen säätelyssä

Julkaisut

• Paakinaho, Ville; Lempiäinen, Joanna K; Sigismondo, Gianluca; Niskanen, Einari A; Malinen, Marjo; Jääskeläinen, Tiina; Varjosalo, Markku; Krijgsveld, Jeroen; Palvimo, Jorma J. 2021. SUMOylation regulates the protein network and chromatin accessibility at glucocorticoid receptor-binding sites Nucleic acids research 49 4: 1951-1971. 2021
• Jaillard, Sylvie; Bell, Katrina; Akloul, Linda; Walton, Kelly; McElreavy, Kenneth; Stocker, William A; Beaumont, Marion; Harrisson, Craig; Jääskeläinen, Tiina; Palvimo, Jorma J; Robevska, Gorjana; Launay, Erika; Satié, Anne-Pascale; Listyasari, Nurin; Bendavid, Claude; Sreenivasan, Rajini; Duros, Solène; van den Bergen, Jocelyn; Henry, Catherine; Domin-Bernhard, Mathilde et al.. 2020. New insights into the genetic basis of premature ovarian insufficiency: novel causative variants and candidate genes revealed by genomic sequencing Maturitas 141: 9-19. 2020
• Zhang, Fu-Ping; Malinen, Marjo; Mehmood, Arfa; Lehtiniemi, Tiina; Jääskeläinen, Tiina; Niskanen, Einari A; Korhonen, Hanna; Laiho, Asta; Elo, Laura L; Ohlsson, Claes; Kotaja, Noora; Poutanen, Matti; Sipilä, Petra; Palvimo, Jorma J. 2019. Lack of androgen receptor SUMOylation results in male infertility due to epididymal dysfunction Nature communications 10: 777. 2019
• Anttonen Anna-Kaisa, Laari Anni, Kousi Maria, Yang Yawei J, Jääskeläinen Tiina, Somer Mirja, Siintola Eija, Jakkula Eveliina, Muona Mikko, Tegelberg Saara, Lönnqvist Tuula, Pihko Helena, Valanne Leena, Paetau Anders, Lun Melody P, Hästbacka Johanna, Kopra Outi, Joensuu Tarja, Katsanis Nicholas, Lehtinen Maria K, Palvimo Jorma J, Lehesjoki Anna-Elina. 2017. ZNHIT3 is defective in PEHO syndrome, a severe encephalopathy with cerebellar granule neuron loss. BRAIN 140 5: 1267-1279. 2017
• Känsäkoski Johanna, Jääskeläinen Jarmo, Jääskeläinen Tiina, Tommiska Johanna, Saarinen Lilli, Lehtonen Rainer, Hautaniemi Sampsa, Frilander Mikko J, Palvimo Jorma J, Toppari Jorma, Raivio Taneli. 2016. Complete androgen insensitivity syndrome caused by a deep intronic pseudoexon-activating mutation in the androgen receptor gene. Scientific Reports 6: 32819. 2016
• Navia-Paldanius D, Patel JZ, López Navarro M, Jakupovic H, Goffart S, Pasonen-Seppänen S, Nevalainen TJ, Jääskeläinen T, Laitinen T, Laitinen JT, Savinainen JR. 2016. Chemoproteomic, biochemical and pharmacological approaches in the discovery of inhibitors targeting human alfa/beta-hydrolase domain containing 11 (ABHD11). EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 93: 253-263. 2016
• Malinen Marjo, Toropainen Sari, Jääskeläinen Tiina, Sahu Biswajyoti, Jänne Olli A, Palvimo Jorma J. 2015. Androgen receptor- and PIAS1-regulated gene programs in molecular apocrine breast cancer cells. MOLECULAR AND CELLULAR ENDOCRINOLOGY 414: 91-98. 2015
• Sundén Henrik, Holland Mareike C, Poutiainen Pekka K, Jääskeläinen Tiina, Pulkkinen Juha T, Palvimo Jorma J, Olsson Roger. 2015. Synthesis and Biological Evaluation of Second-Generation Tropanol-Based Androgen Receptor Modulators. JOURNAL OF MEDICINAL CHEMISTRY 58 3: 1569-1574. 2015
• Liimatta Jani, Laakso Saila, Utriainen Pauliina, Voutilainen Raimo, Palvimo Jorma J, Jääskeläinen Tiina, Jääskeläinen Jarmo. 2014. Serum androgen bioactivity is low in children with premature adrenarche. PEDIATRIC RESEARCH 75 5: 645-650. 2014
• Poutiainen Pekka K, Huhtala Tuulia, Jääskeläinen Tiina, Petsalo Aleksanteri, Küblbeck Jenni, Kaikkonen Sanna, Palvimo Jorma J, Raunio Hannu, Närvänen Ale, Peräkylä Mikael, Juvonen Risto O, Honkakoski Paavo, Laatikainen Reino, Pulkkinen Juha T. 2014. Preclinical pharmacology of FL442, a novel nonsteroidal androgen receptor modulator. MOLECULAR AND CELLULAR ENDOCRINOLOGY 387: 8-18. 2014
• Toropainen Sari, Malinen Marjo, Kaikkonen Sanna, Rytinki Miia, Jääskeläinen Tiina, Sahu Biswajyoti, Jänne Olli A, Palvimo Jorma J. 2014. SUMO ligase PIAS1 functions as a target gene selective androgen receptor coregulator on prostate cancer cell chromatin. NUCLEIC ACIDS RESEARCH 2015; 43 2: 848-861. 2014
• Jääskeläinen T, Paananen J, Lindström J, Eriksson JG, Tuomilehto J, Uusitupa M. 2013. Genetic predisposition to obesity and lifestyle factors - the combined analyses of twenty-six known BMI- and fourteen known waist:hip ratio (WHR)-associated variants in the Finnish Diabetes Prevention Study. BRITISH JOURNAL OF NUTRITION 110: 1856-1965. 2013
• Jääskeläinen T, Makkonen H, Visakorpi T, Jaehoon K, Roeder RG, Palvimo JJ. 2012. Histone H2B ubiquitin ligases RNF20 and RNF40 in androgen signaling and prostate cancer cell growth MOLECULAR AND CELLULAR ENDOCRINOLOGY 350: 87-98. 2012
• Malinen M, Jääskeläinen T, Pelkonen M, Heikkinen S, Väisänen S, Kosma VM, Nieminen K, Mannermaa A, Palvimo JJ. 2012. Proto-oncogene PIM-1 is a novel estrogen receptor target associating with high grade breast tumors Molecular and cellular endocrinology 2013; 365 2: 270-276. 2012
• Belikov S, Öberg C, Jääskeläinen T, Rahkama V, Palvimo JJ, Wrange Ö. 2012. FoxA1 corrupts the antiandrogenic effect of bicalutamide but only weakly attenuates the effect of MDV3100 (Enzalutamide). MOLECULAR AND CELLULAR ENDOCRINOLOGY -: -. 2012
• Jääskeläinen T, Makkonen H, Palvimo JJ. 2011. Steroid up-regulation of FKBP51 and its role in hormone signaling. CURRENT OPINION IN PHARMACOLOGY 11: 326-331. 2011
• Makkonen H, Jääskeläinen T, Rytinki MM, Palvimo JJ. 2011. Analysis of androgen receptor activity by reporter gene assays Methods in Molecular Biology 776: 71-80. 2011
• Makkonen H, Kauhanen M, Jääskeläinen T, Palvimo JJ. 2011. Androgen receptor amplification is reflected in the transcriptional responses of Vertebral-Cancer of the Prostate cells MOLECULAR AND CELLULAR ENDOCRINOLOGY 331 1: 57-65. 2011
• Tkachenko Irina V, Jääskeläinen Tiina, Jääskeläinen Jarmo, Palvimo Jorma J, Voutilainen Raimo. 2011. Interleukins 1alfa and 1 beta as regulators of steroidogenesis in human NCI-H295R adrenocortical cells. STEROIDS (NEW YORK NY) 76: 1103-1115. 2011
• Makkonen H, Kauhanen M, Jääskeläinen T & Palvimo JJ. 2010. Androgen receptor amplification is reflected in the transcriptional responses of Vertebral-Cancer on the prostate cells. MOLECULAR AND CELLULAR ENDOCRINOLOGY 331: 57-65. 2010
• Paakinaho V, Makkonen H, Jääskeläinen T & Palvimo JJ. 2010. Glucocorticoid receptor activates poised FKBP51 locus through long-distance interactions MOLECULAR ENDOCRINOLOGY 24: 511-525. 2010
• Rytinki MM, Kaikkonen S, Pehkonen P, Jääskeläinen T, Palvimo JJ. 2009. PIAS proteins: pleiotropic interactors associated with SUMO. CELLULAR AND MOLECULAR LIFE SCIENCES: CMLS 66 18: 3029-3041. 2009
• Kaikkonen S, Jääskeläinen T, Karvonen U, Rytinki MM, Makkonen H, Gioeli D, Paschal BM, Palvimo JJ. 2009. SUMO-specific protease 1 (SENP1) reverses the hormone-augmented SUMOylaiton of androgen receptor and moulates gene responses in prostate cancer cells. MOLECULAR ENDOCRINOLOGY 23 3: 292-307. 2009
• Makkonen H, Kauhanen M, Paakinaho V, Jääskeläinen T, Palvimo JJ. 2009. Long-range activation of FKBP51 transkription by the androgen receptor via distal intronic enhancers NUCLEIC ACIDS RESEARCH 37 12: 4135-4148. 2009
• Makkonen H, Jääskeläinen T, Pitkänen-Arsiola T, Rytinki M, Waltering KK, Mättö M, Visakorpi T, Palvimo JJ. 2008. Identification of ETS-like transcription factor as a novel androgen receptor target in prostate cancer cells. ONCOGENE (LONDON) 27: 4865-4876. 2008
• Mikhaylova IV, Jääskeläinen T, Jääskeläinen J, Palvimo JJ, Voutilainen R. 2008. Leukemia inhibitory factor as a regulator of steroidogenesis in human NCI-H295R adrenocortical cells JOURNAL OF ENDOCRINOLOGY 199: 435-444. 2008
• Karvonen U, Jääskeläinen T, Rytinki M, Kaikkonen S, Palvimo JJ. 2008. ZNF451 is a novel PML body- and SUMO-associated transcriptional coregulator JOURNAL OF MOLECULAR BIOLOGY 382: 585-600. 2008
• Jääskeläinen T, Huhtakangas J, Mäenpää PH. 2005. Negative regulation of human parathyroid hormone gene promoter by Vitamin D3 through nuclear factor Y. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 328: 831-837. 2005
• Jääskeläinen T, Ryhänen S, Mäenpää PH. 2003. 9-cis retinoic acid accelerates calcitriol-induced osteocalcin production and promotes degradation of both vitamin D receptor and retinoid x receptor in human osteoblastic cells. JOURNAL OF CELLULAR BIOCHEMISTRY 89: 1164-1176. 2003
• Ryhänen S, Jääskeläinen T, Mahonen A, Mäenpää P. 2003. Inhibition of MG-63 cell cycle progression by synthetic vitamin D3 analogs mediated by p27, Cdk2, cyclin E, and the retinoblastoma protein. BIOCHEMICAL PHARMACOLOGY 66: 495-504. 2003
• Mäenpää PH, Jääskeläinen T, Ryhänen S, Mahonen A. 2002. Mechanism of action of superactive vitamin D analogs through regulated receptor degradation: Tsambaos D, Merk H, Modern Trends in Skin Pharmacology.Parissianos Medical Publications. 22-26. 2002
• Mäenpää PH, Väisänen S, Jääskeläinen T, Ryhänen S, Rouvinen J, Duchier C, Mahonen A. 2001. Vitamin D3 analogs (MC 1288, KH 1060, EB 1089, GS 1558, and CB 1093): studies on their mechanism of action STEROIDS (NEW YORK NY) 66: 223-225. 2001
• Mäenpää PH, Väisänen S, Jääskeläinen T, Ryhänen S. 2000. Mechanism of action of 20-epi analogs of 1alfa, 25(OH)2D3 with respect to activation of gene transcription: Norman AW, Bouillon R, Thomasset M, Vitamin D Endocrine System. Structural, Biological, Genetic and Clinical Aspects. Proceedings of the Eleventh Workshop on Vitamin D.University of California, Printing and Reprographics. 215-221. 2000
• Jääskeläinen T, Ryhänen S, Mahonen A, DeLuca HF, Mäenpää PH. 2000. Mechanism of action of superactive vitamin D analogs through regulated receptor degradation. JOURNAL OF CELLULAR BIOCHEMISTRY 76: 548-558. 2000
• Jääskeläinen T, Ryhänen S, Mäenpää PH. 2000. Regulation of vitamin D receptor protein levels and transactivation by 9-cis retinoic acid: Norman AW, Bouillon R, Thomasset M, Vitamin D Endocrine System. Structural, Biological, Genetic and Clinical Aspects. Proceedings of the Eleventh Workshop on Vitamin D.University of California, Printing and Reprographics. 283-286. 2000
• Ryhänen S, Jääskeläinen T, Saarela JTA, Mäenpää PH. 1998. Inhibition of proliferation and induction of differentiation of osteoblastic cells by a novel 1,25-dihydroxyvitamin D3 analog with an extensively modified side chain (CB1093). JOURNAL OF CELLULAR BIOCHEMISTRY 70: 414-424. 1998
• Jääskeläinen T. 1997. Gene Expression Regulated by Vitamin D in Bone Cells. Interactions of Vitamin D Receptor with its DNA Response Elements. Kuopion yliopiston julkaisuja C. Luonnontieteet ja ympäristötieteet. 1997
• Ryhänen S, Pirskanen A, Jääskeläinen T, Mäenpää PH. 1997. State of methylation of the human osteocalcin gene in bone-derived and other types of cells JOURNAL OF CELLULAR BIOCHEMISTRY 66: 404-412. 1997
• Mahonen A, Jääskeläinen T, Mäenpää PH. 1996. A novel vitamin D analog with two double bonds in its side chain. A potent inducer of osteoblastic cell differentiation BIOCHEMICAL PHARMACOLOGY 51: 887-892. 1996
• Ryhänen S, Mahonen A, Jääskeläinen T, Mäenpää PH. 1996. Synthetic 20-epi analogs of calcitriol are potent inducers of target-gene activation in osteoblastic cells. FEBS JOURNAL 238: 97-103. 1996
• Jääskeläinen T, Itkonen A, Mäenpää PH. 1995. Retinoid-X-receptor-alpha-independent binding of vitamin D receptor to its response element from human osteocalcin gene. FEBS JOURNAL 228: 222-228. 1995
• Mäenpää PH, Jääskeläinen T, Mahonen A. 1995. Effects of a new vitamin D analog, EB 1089, on osteoblastic cells. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 761: 349-350. 1995