
Timo Lakka
Professori
Lääketieteellisen fysiologian professori
Lääketieteen laitos, Biolääketiede
timo.lakka@uef.fi | 040 770 7329
0407707329
040 7707329
040 770 7329
+358 40 770 7329
+35840 770 7329
040 7707 329
+358 40 7707 329
+35840 7707 329
+358 40 7707329
+35840 7707329
+358407707329
040 7707329
040 770 7329
+358 40 770 7329
+35840 770 7329
040 7707 329
+358 40 7707 329
+35840 7707 329
+358 40 7707329
+35840 7707329
+358407707329
Tutkimusryhmät
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Lasten liikunta ja ravitsemus -tutkimus (PANIC) 01.01.2007 -
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StopDia
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T2D-Data
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Vaikuttavuuden talo 01.11.2018 -
Projektit
Tiedostot
1 kappalettaJulkaisut
289 kappaletta-
Associations between weight loss history and factors related to type 2 diabetes risk in the Stop Diabetes study
Halali, F.; Lapveteläinen, A.; Aittola, K.; Männikkö, R.; Tilles-Tirkkonen, T.; Järvelä-Reijonen, E.; Absetz, P.; Kolehmainen, M.; Schwab, U.; Lindström, J.; Lakka, T. A.; Pihlajamäki, J.; Karhunen, L.. International journal of obesity Published online: 12 January 2022: 1 - 8. 2022 -
Enhanced Eating Competence Is Associated with Improved Diet Quality and Cardiometabolic Profile in Finnish Adults with Increased Risk of Type 2 Diabetes
Aittola, Kirsikka; Karhunen, Leila; Männikkö, Reija; Järvelä-Reijonen, Elina; Mikkonen, Santtu; Absetz, Pilvikki; Kolehmainen, Marjukka; Schwab, Ursula; Harjumaa, Marja; Lindström, Jaana; Lakka, Timo; Tilles-Tirkkonen, Tanja; Pihlajamäki, Jussi. Nutrients 13 11: 4030. 2021 -
The trans-ancestral genomic architecture of glycemic traits
Chen, J; Spracklen, CN; Marenne, G; Varshney, A; Corbin, LJ; Luan, J; Willems, SM; Wu, Y; Zhang, X; Horikoshi, M; Boutin, TS; Mägi, R; Waage, J; Li-Gao, R; Chan, KHK; Yao, J; Anasanti, MD; Chu, AY; Claringbould, A; Heikkinen, J; et al. [incl. Kuulasmaa, T; Kuusisto, J; Laakso, M; Lakka, T; Uusitupa, M; Vangipurapu, J]. Nature genetics 53 6: 840-860. 2021 -
The independent and interactive associations of physical activity intensity and vitamin D status with bone mineral density in prepubertal children: the PANIC Study
Constable, AM; Vlachopoulos, D; Barker, AR; Moore, SA; Soininen, S; Haapala, EA; Väistö, J; Westgate, K; Brage, S; Mähönen, A; Lakka, TA. Osteoporosis international 32 8: 1609-1620. 2021 -
The Positive Relationship between Moderate-to-Vigorous Physical Activity and Bone Mineral Content Is Not Mediated by Free Leptin Index in Prepubertal Children: The PANIC Study
Constable, Annie M.; Porter, Josie E.; Benger, Danielle; Vlachopoulos, Dimitris; Barker, Alan R.; Moore, Sarah A.; Soininen, Sonja; Haapala, Eero A.; Westgate, Kate; Brage, Soren; Agostinete, Ricardo R.; Fernandes, Romulo A.; Lakka, Timo A.. International journal of environmental research and public health 18 10: 5365. 2021 -
Response
Haapala, Eero A; Barker, Alan R; Lakka, Timo A. Medicine and science in sports and exercise 53 2: 454. 2021 -
Associations of physical activity, sedentary time, and diet quality with biomarkers of inflammation in children
Haapala, Eero A; Väistö, Juuso; Ihalainen, Johanna K; Tomaselli González, Claudia; Leppänen, Marja H; Veijalainen, Aapo; Sallinen, Taisa; Eloranta, Aino-Maija; Ekelund, Ulf; Schwab, Ursula; Brage, Soren; Atalay, Mustafa; Lakka, Timo A. European journal of sport science [Epub ahead of print 14 March 2021]: 1-10. 2021 -
Hyvällä mielellä Pohjois-Savo -hankkeen esiselvitys: Toimenpide-ehdotus ja vaikuttavuuden arviointisuunnitelma
Saijonkari, Maija; Paronen, Elsa; Lakka, Timo; Tolmunen, Tommi; Linnosmaa, Ismo; Lammintakanen, Johanna; Mäki-Opas, Tomi. 2021 2021 -
Comparison of Communication Channels for Large-Scale Type 2 Diabetes Risk Screening and Intervention Recruitment: Empirical Study
Jalkanen, Kari; Järvenpää, Riia; Tilles-Tirkkonen, Tanja; Martikainen, Janne; Aarnio, Emma; Männikkö, Reija; Rantala, Eeva; Karhunen, Leila; Kolehmainen, Marjukka; Harjumaa, Marja; Poutanen, Kaisa; Ermes, Miikka; Absetz, Pilvikki; Schwab, Ursula; Lakka, Timo; Pihlajamäki, Jussi; Lindström, Jaana; The StopDia Study Group. JMIR diabetes 6 3: e21356. 2021 -
Plasma irisin and its associations with oxidative stress in athletes suffering from overtraining syndrome
Joro, R; Korkmaz, A; Lakka, TA; Uusitalo, ALT; Atalay, M. Physiology international 10 4: 513-526. 2021 -
Exercise, diet, and cognition in a 4-year randomized controlled trial: Dose-Responses to Exercise Training (DR's EXTRA)
Komulainen, Pirjo; Tuomilehto, Jaakko; Savonen, Kai; Männikkö, Reija; Hassinen, Maija; Lakka, Timo A; Hänninen, Tuomo; Kiviniemi, Vesa; Jacobs, David R; Kivipelto, Miia; Rauramaa, Rainer. American journal of clinical nutrition 113 6: 1428-1439. 2021 -
Longitudinal associations of physical activity, sedentary time, and cardiorespiratory fitness with arterial health in children - the PANIC study
Korhonen, Marika; Väisto, Juuso; Veijalainen, Aapo; Leppänen, Marja; Ekelund, Ulf; Laukkanen, Jari A; Brage, Soren; Lintu, Niina; Haapala, Eero A; Lakka, Timo A. Journal of sports sciences 39 17: 1980-1987. 2021 -
Cost-effectiveness of physical activity intervention in children - results based on the Physical Activity and Nutrition in Children (PANIC) study
Kuvaja-Köllner, Virpi; Lintu, Niina; Lindi, Virpi; Rissanen, Elisa; Eloranta, Aino-Maija; Kiiskinen, Sanna; Martikainen, Janne; Kankaanpää, Eila; Valtonen, Hannu; Lakka, Timo A.. International journal of behavioral nutrition and physical activity 18 1: 116. 2021 -
Oxygen-18 and Carbon-13 isotopes in eCO 2 and erythrocytes carbonic anhydrase activity of Finnish prediabetic population
Kårlund, Anna; Kääriäinen, Teemu; Kostamo, Vili M; Kokkola, Tarja; Kolehmainen, Marjukka; Lakka, Timo A; Pihlajamäki, Jussi; Manninen, Albert. Journal of breath research 15 2: 021001. 2021 -
Longitudinal and cross-sectional associations of adherence to 24-hour movement guidelines with cardiometabolic risk
Leppänen, Marja H; Haapala, Eero A; Väistö, Juuso; Ekelund, Ulf; Brage, Søren; Kilpeläinen, Tuomas O; Lakka, Timo A. Scandinavian journal of medicine and science in sports 2022; 32 1: 255-266. 2021 -
Dental caries among Finnish teenagers participating in physical activity and diet intervention: association with anthropometrics and behavioural factors
Methuen, Mirja; Kauppinen, Sofia; Suominen, Anna Liisa; Eloranta, Aino-Maija; Väistö, Juuso; Lakka, Timo; Vähänikkilä, Hannu; Anttonen, Vuokko. Bmc oral health 21 1: 333. 2021 -
Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability
Mägi, Reedik; Hottenga, Jouke- Jan; Grallert, Harald; Perry, John R. B.; Bouatia-Naji, Nabila; Marullo, Letizia; Rybin, Denis; Jansen, Rick; Min, Josine L.; Dimas, Antigone S.; Ulrich, Anna; Zudina, Liudmila; Gådin, Jesper R.; Jiang, Longda; Faggian, Alessia; Bonnefond, Amélie; Fadista, Joao; Stathopoulou, Maria G.; Isaacs, Aaron; Willems, Sara M et al. [incl. Kuusisto, Johanna; Laakso, Markku; La. Nature communications 12 1: 24. 2021 -
Multi-ancestry genome-wide association study accounting for gene-psychosocial factor interactions identifies novel loci for blood pressure traits
Sun, Daokun; Richard, Melissa A.; Musani, Solomon K.; Sung, Yun Ju; Winkler, Thomas W.; Schwander, Karen; Chai, Jin Fang; Guo, Xiuqing; Kilpeläinen, Tuomas O.; Vojinovic, Dina; Aschard, Hugues; Bartz, Traci M.; Bielak, Lawrence F.; Brown, Michael R.; Chitrala, Kumaraswamy; Hartwig, Fernando P.; Horimoto, Andrea R.V.R.; Liu, Yongmei; Manning, Alisa K.; Noordam, Raymond et al. [incl. Heikkinen, Sam. Human Genetics and Genomics Advances 2 1: 100013. 2021 -
Liikunnallisuus ja hyvä kunto ehkäisevät tyypin 2 diabetesta ja valtimotautien riskitekijöitä lapsuudesta lähtien
Väistö, Juuso; Haapala, Eero; Lakka, Timo A. Liikunta ja tiede 58 3: 62-64. 2021 -
Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci
de Las Fuentes, Lisa; Sung, Yun Ju; Noordam, Raymond; Winkler, Thomas; Feitosa, Mary F; Schwander, Karen; Bentley, Amy R; Brown, Michael R; Guo, Xiuqing; Manning, Alisa; Chasman, Daniel I; Aschard, Hugues; Bartz, Traci M; Bielak, Lawrence F; Campbell, Archie; Cheng, Ching-Yu; Dorajoo, Rajkumar; Hartwig, Fernando P; Horimoto, A R V R; Li, Changwei et al [incl. Heikkinen, Sami; Lakka, Timo]. Molecular psychiatry 2021; 26 6: 2111-2125. 2020 -
Effects of a 2-Year Lifestyle Intervention on Cardiorespiratory Fitness in 6-8- Year-Old Children: The PANIC Study
Agbaje, AO; Barker, AR; Eloranta, A-M; Haapala, EA; Lintu, N; Savonen, K; Kilpeläinen, TO; Brage, S; Lakka, TA. Pediatric exercise science. 2020. 2020 -
The effects of a 2-year physical activity and dietary intervention on plasma lipid concentrations in children: the PANIC Study
Eloranta, Aino-Maija; Sallinen, Taisa; Viitasalo, Anna; Lintu, Niina; Väistö, Juuso; Jalkanen, Henna; Tompuri, Tuomo T; Soininen, Sonja; Haapala, Eero A; Kiiskinen, Sanna; Schnurr, Theresia M; Kilpeläinen, Tuomas O; Mikkonen, Santtu; Savonen, Kai; Atalay, Mustafa; Brage, Soren; Laaksonen, David E; Lindi, Virpi; Ågren, Jyrki; Schwab, Ursula; et al. [incl. Jääskeläinen, Jarmo; Lakka, Timo]. European journal of nutrition 2021; 60: 425-434. 2020 -
Associations between cardiorespiratory fitness, motor competence, and adiposity in children
Haapala, Eero A; Gao, Ying; Lintu, Niina; Väistö, Juuso; Vanhala, Anssi; Tompuri, Tuomo; Lakka, Timo A; Finni, Taija. Translational sports medicine 2021; 4 1: 56-64. 2020 -
Leisure-time cross-country skiing and the risk of venous thromboembolism: A prospective cohort study
Kunutsor, Setor; Lakka, Timo; Kurl, Sudhir; Mäkikallio, Timo; Jae, Sae Young; Laukkanen, Jari. European journal of preventive cardiology 2021; 28 10: 1138-1141. 2020 -
A 2 year physical activity and dietary intervention attenuates the increase in insulin resistance in a general population of children: the PANIC study
Lakka, Timo A; Lintu, Niina; Väistö, Juuso; Viitasalo, Anna; Sallinen, Taisa; Haapala, Eero A; Tompuri, Tuomo T; Soininen, Sonja; Karjalainen, Panu; Schnurr, Theresia M; Mikkonen, Santtu; Atalay, Mustafa; Kilpeläinen, Tuomas O; Laitinen, Tomi; Laaksonen, David E; Savonen, Kai; Brage, Soren; Schwab, Ursula; Jääskeläinen, Jarmo; Lindi, Virpi; Eloranta, Aino-Maija. Diabetologia 63: 2270-2281. 2020 -
An overview on the associations between health behaviors and brain health in children and adolescents with special reference to diet quality
Naveed, Sehrish; Lakka, Timo; Haapala, Eero A. International journal of environmental research and public health 17 3: 953. 2020 -
Associations of dietary carbohydrate and fatty acid intakes with cognition among children
Naveed, Sehrish; Venäläinen, Taisa; Eloranta, Aino-Maija; Erkkilä, Arja; Jalkanen, Henna; Lindi, Virpi; Lakka, Timo; Haapala, Eero. Public health nutrition 23 9: 1657-1663. 2020 -
Child-related and Parental Predictors for Thelarche in a General Population of Girls: The PANIC Study
Savinainen, SE; Viitasalo, A; Sallinen, TM; Jääskeläinen, JES; Lakka, TA. Pediatric research 88 4: 676-680. 2020 -
Suomalaisten lasten ja nuorten ruokaympäristö ja toimenpide-ehdotukset sen kehittämiseen terveyttä edistäväksi
Rantala, Eeva; Martikainen, Janne; Lakka, Timo; Vanhatalo, Saara; Heiskanen, Jari; Väistö, Juuso; Leväsluoto, Johanna; Hassinen, Maija; Eloranta, Aino-Maija; Sigfrids, Anton; Harjumaa, Marja. 2020 2020 -
Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals
Surendran, Praveen; Feofanova, Elena V; Lahrouchi, Najim; Ntalla, Ioanna; Karthikeyan, Savita; Cook, James; Chen, Lingyan; Mifsud, Borbala; Yao, Chen; Kraja, Aldi T; Cartwright, James H; Hellwege, Jacklyn N; Giri, Ayush; Tragante, Vinicius; Thorleifsson, Gudmar; Liu, Dajiang J; Prins, Bram P; Stewart, Isobel D; Cabrera, Claudia P; Eales, James M; et al. (incl. Stanakova, Alena; Laatikainen, Tiina;. Nature genetics 52: 1314-1332. 2020 -
Primary hand motor representation areas in healthy children, preadolescents, adolescents, and adults
Säisänen, Laura; Könönen, Mervi; Niskanen, Eini; Lakka, Timo; Lintu, Niina; Vanninen, Ritva; Julkunen, Petro; Määttä, Sara. Neuroimage 2021; 228: 117702. 2020 -
StopDia-hankkeesta vinkkejä terveyden edistämiseen ja hyte-johtamiseen
Tilles-Tirkkonen, Tanja; Männikkö, Reija; Lindström, Jaana; Harjumaa, Marja; Aittola, Kirsikka; Järvelä-Reijonen, Elina; Rantala, Eeva; Martikainen, Janne; Lakka, Timo; Pihlajamäki, Jussi. Ravitsemusasiantuntija 6 1: 4-7. 2020 -
Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits
Vogelezang, Suzanne; Bradfield, Jonathan P; Ahluwalia, Tarunveer S; Curtin, John A; Lakka, Timo A; Grarup, Niels; Scholz, Markus; van der Most, Peter J; Monnereau, Claire; Stergiakouli, Evie; Heiskala, Anni; Horikoshi, Momoko; Fedko, Iryna O; Vilor-Tejedor, Natalia; Cousminer, Diana L; Standl, Marie; Wang, Carol A; Viikari, Jorma; Geller, Frank; Íñiguez, Carmen; et al. (Incl. Atalay, Mustafa; Lind. PLoS genetics 16 10: e1008718. 2020 -
Associations of Cardiorespiratory Fitness and Adiposity With Arterial Stiffness and Arterial Dilatation Capacity in Response to a Bout of Exercise in Children
Agbaje, Andrew O; Haapala, Eero A; Lintu, Niina; Viitasalo, Anna; Vaisto, Juuso; Khan, Sohaib; Veijalainen, Aapo; Tompuri, Tuomo; Laitinen, Tomi; Lakka, Timo A. Pediatric exercise science 31 2: 238-247. 2019 -
GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI
Alves, AC; De Silva, NMG; Karhunen, V; Sovio, U; Das, S; Rob Taal, H; Warrington, NM; Lewin, AM; Kaakinen, M; Cousminer, DL; Thiering, E; Timpson, NJ; Bond, TA; Lowry, E; Brown, CD; Estivill, X; Lindi, V; Bradfield, JP; Geller, F; Speed, D; et al. for BIOS Consortium [incl. Lakka, TA]. Science advances 5 9: eaaw3095. 2019 -
Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids
Bentley, AR; Sung, YJ; Brown, MR; Winkler, TW; Kraja, AT; Ntalla, I; Schwander, K; Chasman, DI; Lim, E; Deng, X; Guo, X; Liu, J; Lu, Y; Cheng, CY; Sim, X; Vojinovic, D; Lakka, TA; Heikkinen, S; Kuusisto, J; Laakso, M; et al. (incl. Laakso, Markku; Heikkinen, Sami; Kuusisto, Johanna; Lakka, Timo; Rauramaa, Rainer). Nature genetics 51 4: 636-648. 2019 -
A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity
Bradfield, Jonathan P; Vogelezang, Suzanne; Felix, Janine F; Chesi, Alessandra; Helgeland, Øyvind; Horikoshi, Momoko; Karhunen, Ville; Lowry, Estelle; Cousminer, Diana L; Ahluwalia, Tarunveer S; Thiering, Elisabeth; Boh, Eileen Tai-Hui; Zafarmand, Mohammad H; Vilor-Tejedor, Natalia; Wang, Carol A; Joro, Raimo; Chen, Zhanghua; Gauderman, William J; Pitkänen, Niina; Parra, Esteban J; et al. (incl. A. Human molecular genetics 28 19: 3327-3338. 2019 -
Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions
de Vries, PS; Brown, MR; Bentley, AR; Sung, YJ; Winkler, TW; Ntalla, I; Schwander, K; Kraja, AT; Guo, X; Franceschini, N; Cheng, CY; Sim, X; Vojinovic, D; Huffman, JE; Musani, SK; Li, C; Feitosa, MF; Richard, MA; Noordam, R; Aschard, H; et al. (Incl. Kuusisto, Johanna; Laakso, Markku; Lakka, Timo; Heikkinen, Sami). American journal of epidemiology 188 6: 1033-1054. 2019 -
Fyysinen aktiivisuus ja ravitsemus lasten terveyden edistämisessä - tavoitteena lihavuuden, tyypin 2 diabeteksen ja valtimotautien ehkäisy
Lakka, Timo A; Talvia, Sanna; Sääkslahti, Arja; Haapala, Eero / Näkökulmia terveyteen ja sen edistämiseen. 2019. 2019 -
Cardiorespiratory Fitness, Physical Activity, and Insulin Resistance in Children
Haapala, EA; Wiklund, P; Lintu, N; Tompuri, T; Väistö, J; Finni, T; Tarkka, IM; Kemppainen. T; Barker, AR; Ekelund, U; Brage, S; Lakka, TA. Medicine and science in sports and exercise 2020; 52 5: 1144-1152. 2019 -
Longitudinal Associations of Fitness, Motor Competence, and Adiposity with Cognition
Haapala, Eero A; Lintu, Niina; Väistö, Juuso; Tompuri, Tuomo; Soininen, Sonja; Viitasalo, Anna; Eloranta, Aino-Maija; Venäläinen, Taisa; Sääkslahti, Arja; Laitinen, Tomi; Lakka, Timo A. Medicine and science in sports and exercise 51 3: 465-471. 2019 -
Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution
Justice, AE; Karaderi, T; Highland, HM; Young, KL; Graff, M; Lu, Y; Turcot, V; Auer, PL; Fine, RS; Guo, X; Schurmann, C; Lempradl, A; Marouli, E; Mahajan, A; Winkler, TW; Locke, AE; Medina-Gomez, C; Esko, T; Vedantam, S; Giri, A; Lo, KS; et al. (Incl. Kuusisto, Johanna; Laakso, Markku; Lakko, Timo; Uusitupa, Matti; Vanhala, Mauno). Nature genetics 51: 452-469. 2019 -
Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity
Kilpeläinen, TO; Bentley, AR; Noordam, R; Sung, YJ; Schwander, K; Winkler, TW; Jakupovic, H; Chasman, DI; Manning, A; Ntalla, I; Aschard, H; Brown, MR; de Las Fuentes, L; Franceschini, N; Guo, X; Vojinovic, D; Aslibekyan, S; Feitosa, MF; Kho, M; Musani, SK; et al. [Incl. Lakka, Timo; Heikkinen, Sami; Kuusisto, Johanna; Laakso, Markku]. Nature communications 10 1: 376. 2019 -
Cross-country skiing and the risk of acute myocardial infarction: A prospective cohort study
Laukkanen, JA; Lakka, TA; Ogunjesa, BA; Kurl, S; Kunutsor, SK. European journal of preventive cardiology [First Published August 19, 2019]: 1-4. 2019 -
Associations of cardiometabolic risk factors with heart rate variability in 6-8-year-old children: the PANIC Study
Leppänen, MH; Haapala, EA; Veijalainen, A; Seppälä, S; Oliveira, RS; Lintu, N; Laitinen, T; Tarvainen, MP; Lakka, TA. Pediatric diabetes 2020; 21 2: 251-258. 2019 -
The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects
Middeldorp, Christel M; Felix, Janine F; Mahajan, Anubha; EArly Genetics Lifecourse Epidemiology (EAGLE) consortium; Early Growth Genetics (EGG) consortium (Incl Atalay, Mustafa; Lakka, Timo A); McCarthy, Mark I. European journal of epidemiology 34 3: 279-300. 2019 -
Hyvinvoinnin ja osallisuuden edistäminen vaatii uusia vaikuttavia keinoja
Mäki-Opas, Tomi; Tilles-Tirkkonen, Tanja; Saari, Eveliina; Järvenpää, Riia; Lindström, Jaan; Karhunen, Leila; Kurki, Marjo; Pihlajamäki, Jussi; Niemi, Anna-Maija; Laaksonen, Linda Maria; Korkiakangas, Eveliina; Lakka, Timo; Vaarama, Marja; Laitinen, Jaana. Policy Brief / SA 13.3.2019: 1-12. 2019 -
Associations of IGF-1 and Adrenal Androgens with Cognition in Childhood
Mäntyselkä, A; Haapala, EA; Lindi, V; Häkkinen, MR; Auriola, S; Jääskeläinen, J; Lakka, TA. Hormone research in paediatrics 91: 329-335. 2019 -
Maturation changes the excitability and effective connectivity of the frontal lobe: A developmental TMS-EEG study
Määttä, S; Säisänen, L; Kallioniemi, E; Lakka, TA; Lintu, N; Haapala, EA; Koskenkorva, P; Niskanen, E; Ferreri, F; Könönen, M. Human brain mapping 40 8: 2320-2335. 2019 -
Digitally supported program for type 2 diabetes risk identification and risk reduction in real-world setting: protocol for the StopDia model and randomized controlled trial
Pihlajamäki, J; Männikkö, R; Tilles-Tirkkonen, T; Karhunen, L; Kolehmainen, M; Schwab, U; Lintu, N; Paananen, J; Järvenpää, R; Harjumaa, M; Martikainen, J; Kohl, J; Poutanen, K; Ermes, M; Absetz, P; Lindström, J; Lakka, TA. Bmc public health 19: 255. 2019 -
A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure
Sung, Yun Ju; de Las Fuentes, Lisa; Winkler, Thomas W; Chasman, Daniel I; Bentley, Amy R; Kraja, Aldi T; Ntalla, Ioanna; Warren, Helen R; Guo, Xiuqing; Schwander, Karen; Manning, Alisa K; Brown, Michael R; Aschard, Hugues; Feitosa, Mary F; Franceschini, Nora; Lu, Yingchang; et al. (incl. Heikkinen, Sami; Kuusisto, Johanna; Laakso, Markku; Stancáková, Alena; Lakka, Timo A). Human molecular genetics 28 15: 2615-2633. 2019 -
Functional and structural asymmetry in primary motor cortex in Asperger syndrome: a navigated TMS and imaging study
Säisänen, L; Määttä, S; Julkunen, P; Niskanen, E; Kallioniemi, E; Gröhn, H; Kemppainen, S; Lakka, TA; Lintu, N; Eloranta, AM; Vanninen, R; Makkonen, I; Könönen, M. Brain topography 32 3: 504-518. 2019 -
Integrative analysis of gene expression, DNA methylation, physiological traits, and genetic variation in human skeletal muscle
Taylor, DL; Jackson, AU; Narisu, N; Hemani, G; Erdos, MR; Chines, PS; Swift, A; Idol, J; Didion, JP; Welch, RP; Kinnunen, L; Saramies, J; Lakka, TA; Laakso, M; Tuomilehto, J; Parker, SCJ; Koistinen, HA; Davey Smith, G; Boehnke, M; Scott, LJ; et al.. Proceedings of the National Academy of Sciences of the United States of America 116 22: 10883-10888. 2019 -
Eating Competence Is Associated with Lower Prevalence of Obesity and Better Insulin Sensitivity in Finnish Adults with Increased Risk for Type 2 Diabetes: The StopDia Study
Tilles-Tirkkonen, Tanja; Aittola, Kirsikka; Männikkö, Reija; Absetz, Pilvikki; Kolehmainen, Marjukka; Schwab, Ursula; Lindström, Jaana; Lakka, Timo; Pihlajamäki, Jussi; Karhunen, Leila. Nutrients 2020; 12 1: 104. 2019 -
Adiposity Criteria in Assessing Increased Cardiometabolic Risk in Prepubertal Children
Tompuri, Tuomo Tapani; Jaaskelainen, Jarmo; Lindi, Virpi; Laaksonen, David Elliot; Eloranta, Aino-Maija; Viitasalo, Anna; Laitinen, Tomi; Lakka, Limo Antero. Frontiers in endocrinology 10: 410. 2019 -
Associations of physical activity, sedentary time, and cardiorespiratory fitness with heart rate variability in 6- to 9-year-old children: the PANIC study
Veijalainen, A; Haapala, EA; Väistö, J; Leppänen, MH; Lintu, N; Tompuri, T; Seppälä, S; Ekelund, U; Tarvainen, MP; Westgate, K; Brage, S; Lakka, TA. European journal of applied physiology 119: 2487-2498. 2019 -
Abdominal adiposity and cardiometabolic risk factors in children and adolescents: a Mendelian randomization analysis
Viitasalo, A; Schnurr, TM; Pitkänen, N; Hollensted, M; Nielsen, TRH; Pahkala, K; Atalay, M; Lind, MV; Heikkinen, S; Frithioff-Bøjsøe, C; Fonvig, CE; Grarup, N; Kähönen, M; Carrasquilla, GD; Larnkjaer, A; Pedersen, O; Michaelsen, KF; Lakka, TA; Holm, JC; Lehtimäki, T; et al.. American journal of clinical nutrition 110 5: 1079-1087. 2019 -
Genetic predisposition to higher body fat yet lower cardiometabolic risk in children and adolescents
Viitasalo, Anna; Schnurr, Theresia M.; Pitkanen, Niina; Hollensted, Mette; Nielsen, Tenna R. H.; Pahkala, Katja; Lintu, Niina; Lind, Mads V.; Atalay, Mustafa; Frithioff-Bojsoe, Christine; Fonvig, Cilius E.; Grarup, Niels; Kahonen, Mika; Larnkjaer, Anni; Pedersen, Oluf; Holm, Jens-Christian; Michaelsen, Kim F.; Lakka, Timo A.; Lehtimaki, Terho; Raitakari, Olli; et al.. International journal of obesity 43: 2007-2016. 2019 -
Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors
Warrington, NM; Beaumont, RN; Horikoshi, M; Day, FR; Helgeland, Ø; Laurin, C; Bacelis, J; Peng, S; Hao, K; Feenstra, B; Wood, AR; Mahajan, A; Tyrrell, J; Robertson, NR; Rayner, NW et al. (ncl. Joro, R; Atalay, M; Eloranta, AM; Lakka, TA). Nature genetics 51 5: 804-814. 2019 -
Peak oxygen uptake cut-points to identify children at increased cardiometabolic risk - The PANIC Study
Agbaje, Andrewe O; Haapala, Eero A; Lintu, Nina; Viitasalo, Anna; Barker, Alan R; Takken, Tim; Tompuri, Tuomo; Lindi, Virpi; Lakka, Timo A. Scandinavian journal of medicine and science in sports 2019; 29 1: 16-24. 2018 -
Associations of cardiorespiratory fitness and adiposity with arterial stiffness and arterial dilation capacity in response to exercise in children
Agbaje, AO; Haapala, EA; Lintu, N; Viitasalo, A; Väistö, J; Khan, S; Veijalainen, A; Tompuri, T; Laitinen, T; Lakka, TA. Pediatric exercise science. 2018. 2018 -
Birth weight is associated with dietary factors at the age of 6-8 years: the Physical Activity and Nutrition in Children (PANIC) study
Eloranta, AM; Jääskeläinen, J; Venäläinen, T; Jalkanen, H; Kiiskinen, S; Mäntyselkä, A; Schwab, U; Lindi, V; Lakka, TA. PUBLIC HEALTH NUTRITION 21 7: 1278-1285. 2018 -
Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries
Feitosa, MF; Kraja, AT; Chasman, DI; Sung, YJ; Winkler, TW; Ntalla, I; Guo, X; Franceschini, N; Cheng, CY; Sim, X; Vojinovic, D; Marten, J; Musani, SK; Li, C; Bentley, AR; Brown, MR; Schwander, K; Richard, MA; Noordam, R; Aschard, H; et al. (incl. Laakso, Markku; Heikkinen, Sami; Kuusisto, Johanna; Lakka, Timo; Yaluri, Alena). PLoS ONE 13 6: e0198166. 2018 -
Mediating effects of motor performance, cardiorespiratory fitness, physical activity, and sedentary behaviour on the associations of adiposity and other cardiometabolic risk factors with academic achievement in children
Haapala, Eero A; Lintu, Niina; Eloranta, Aino-Maija; Venäläinen, Taisa; Poikkeus, Anna-Maija; Ahonen, Timo; Lindi, Virpi; Lakka, Timo A. Journal of Sports Sciences 36 20: 2296-2303. 2018 -
Associations of Genetic Susceptibility to Alzheimer's Disease with Adiposity and Cardiometabolic Risk Factors among Children in a 2-Year Follow-up Study
Haapala, Eero A; Paananen, Jussi; Hiltunen, Mikko; Lakka, Timo A. Journal of Alzheimer's Disease 64 2: 587-595. 2018 -
Consortium-based genome-wide meta-analysis for childhood dental caries traits
Haworth, S; Shungin, D; van der Tas, JT; Vucic, S; Medina-Gomez, C; Yakimov, V; Feenstra, B; Shaffer, JR; Lee, MK; Standl, M; Thiering, E; Wang, C; Bønnelykke, K; Waage, J; Eyrich Jessen, L; Nørrisgaard, PE; Joro, R; Seppälä, I; Raitakari, O; Dudding, T; et al. [Incl Lakka, T; Eloranta, A-M; Vierola, A]. Human molecular genetics 27 17: 3113-3127. 2018 -
Simultaneous analysis by LC-MS/MS of 22 ketosteroids with hydroxylamine derivatization and underivatized estradiol from human plasma, serum and prostate tissue
Häkkinen, Merja R; Murtola, Teemu; Voutilainen, Raimo; Poutanen, Matti; Linnanen, Tero; Koskivuori, Johanna; Lakka, Timo; Jääskeläinen, Jarmo; Auriola, Seppo. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 2019; 164: 642-652. 2018 -
Analysis by LC-MS/MS of endogenous steroids from human serum, plasma, endometrium and endometriotic tissue
Häkkinen, MR; Heinosalo, T; Saarinen, N; Linnanen, T; Voutilainen, R; Lakka, T; Jääskeläinen, J; Poutanen, M; Auriola, S. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 152: 165-172. 2018 -
Health-related correlates of psychological well-being among girls and boys 6-8 years of age: The Physical Activity and Nutrition in Children study
Ikävalko, T; Lehto, S; Lintu, N; Väistö, J; Eloranta, AM; Haapala, EA; Vierola, A; Myllykangas, R; Tuomilehto, H; Brage, S; Pahkala, R; Närhi, M; Lakka, TA. Journal of Paediatrics and Child Health 54 5: 506-509. 2018 -
Lasten ja nuorten kestävyyskunto
Lintu, Niina; Joensuu, Laura; Barker, Alan; Sansum, Kate; Lakka, Timo A; Huotari, Pertti; Haapala, Eero A. Liikunta ja tiede 55 4: 36-43. 2018 -
Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects
Medina-Gomez, C; Kemp, JP; Trajanoska, K; Luan, J; Chesi, A; Ahluwalia, TS; Mook-Kanamori, DO; Ham, A; Hartwig, FP; Evans, DS; Joro, R; Nedeljkovic, I; Zheng, HF; Zhu, K; Atalay, M; Liu, CT; Nethander, M; Broer, L; Porleifsson, G; Mullin, BH et al. [incl. Lakka, T]. American journal of human genetics 102 1: 88-102. 2018 -
Associations of Dehydroepiandrosterone Sulfate with Cardiometabolic Risk Factors in Prepubertal Children
Mäntyselkä, A; Lindi, V; Viitasalo, A; Eloranta, AM; Ågren, J; Väisänen, S; Voutilainen, R; Laitinen, T; Lakka, TA; Jääskeläinen, J. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 103 7: 2592-2600. 2018 -
Uric acid level as a risk factor for cardiovascular and all-cause mortality in middle-aged men. A prospective cohort study (in Russian)
Niskanen, LK; Laaksonen, DE; Nyyssonen, K; Alfthan, G; Lakka, H-M; Lakka, TA; Salonen, J. Kardiologija v Belarusi 10 4: 440-445. 2018 -
Kasvu, sukupuolinen kypsyminen ja kehitys sekä niiden merkitys liikuntatieteissä
Savinainen, Saija; Lakka, Timo A; Vlachopoulos, Dimitris; Sääkslahti, Arja; Helajärvi, Harri; Ihalainen, Johanna K; Finni, Taija; Haapala, Eero A. Liikunta ja tiede 55 4: 23-29. 2018 -
Serum 25-Hydroxyvitamin D, Plasma Lipids, and Associated Gene Variants in Prepubertal Children
Soininen, Sonja; Eloranta, Aino-Maija; Viitasalo, Anna; Dion, Geneviève; Erkkilä, Arja; Sidoroff, Virpi; Lindi, Virpi; Mahonen, Anitta; Lakka, Timo A. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 103 7: 2670-2679. 2018 -
Body fat mass, lean body mass and associated biomarkers as determinants of bone mineral density in children 6-8 years of age - The Physical Activity and Nutrition in Children (PANIC) study
Soininen, Sonja; Sidoroff, Virpi; Lindi, Virpi; Mahonen, Anitta; Kröger, Liisa; Kröger, Heikki; Jääskeläinen, Jarmo; Atalay, Mustafa; Laaksonen, David E; Laitinen, Tomi; Lakka, Timo A. Bone 108: 106-114. 2018 -
Development of corticospinal motor excitability and cortical silent period from mid-childhood to adulthood - a navigated TMS study
Säisänen, Laura; Julkunen, Petro; Lakka, Timo; Lindi, Virpi; Könönen, Mervi; Määttä; Sara. Neurophysiologie Clinique 48 2: 65-75. 2018 -
Interactions between genetic variation and cellular environment in skeletal muscle gene expression
Taylor, DL; Knowles, DA; Scott, LJ; Ramirez, AH; Casale, FP; Wolford, BN; Guan, L; Varshney, A; Albanus, RD; Parker, SC; Narisu, N; Chines, PS; Erdos, MR; Welch, RP; Kinnunen, L; Saramies, J; Sundvall, J; Lakka, TA; Laakso, M; Tuomilehto, J; et al.. PLOS ONE 13 4: e0195788. 2018 -
Longitudinal associations of physical activity and sedentary time with cardiometabolic risk factors in children
Väistö, Juuso; Haapala, Eero A; Viitasalo, Anna; Schnurr, Theresia M; Kilpeläinen, Tuomas O; Karjalainen, Panu; Westgate, Kate; Lakka, Hanna-Maaria; Laaksonen, David E; Ekelund, Ulf; Brage, Søren; Lakka, Timo A. SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS 2019; 29 1: 113-123. 2018 -
Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults
Graff M, Scott RA, Justice AE, Young KL, Feitosa MF, Barata L, Winkler TW, Chu AY, Mahajan A, Hadley D, Xue L, Workalemahu T, Heard-Costa NL, den Hoed M, Ahluwalia TS, Qi Q, Ngwa JS, Renström F, Quaye L, Eicher JD et al.. PLOS GENETICS [ONLINE) 13 4: e1006528. 2017 -
Vähäinen fyysinen aktiivisuus ja runsas fyysinen passiivisuus ovat yhteydessä 6-8-vuotiaiden lasten ylipainoon
Haapala Eero A, Väistö Juuso, Lintu Niina, Eloranta Aino-Maija, Lindi Virpi, Lakka Timo A. LIIKUNTA JA TIEDE 54 2-3: 106-112. 2017 -
Associations of Objectively Measured Physical Activity and Sedentary Time With Arterial Stiffness in Pre-pubertal Children
Haapala Eero, Väistö Juuso, Veijalainen Aapo, Lintu Niina, Wiklund P,etri Westgate Kate, Ekelund Ulf, Lindi Virpi, Brage Soren, Lakka Timo A. PEDIATRIC EXERCISE SCIENCE 29 3: 326-335. 2017 -
High Leisure-Time Physical Activity Is Associated With Reduced Risk of Sudden Cardiac Death Among Men With Low Cardiorespiratory Fitness
Hagnäs, MJ; Lakka, TA; Mäkikallio, TH; Kurl, S; Savonen, K; Rauramaa, R; Laukkanen, JA. Canadian Journal of Cardiology 2018; 34 3: 288-294. 2017 -
Predictors of sleep disordered breathing in children: the PANIC study
Ikävalko, T; Närhi, M; Eloranta, AM; Lintu, N; Myllykangas, R; Vierola, A; Tuomilehto, H; Lakka, T; Pahkala, R. European Journal of Orthodontics 2018; 40 3: 268-272. 2017 -
Eating behaviour is associated with eating frequency and food consumption in 6-8 year-old children: The Physical Activity and Nutrition in Children (PANIC) study
Jalkanen H, Lindi V, Schwab U, Kiiskinen S, Venäläinen T, Karhunen L, Lakka TA, Eloranta AM. APPETITE 114: 28-37. 2017 -
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits
Justice Anne E, Winkler Thomas W, Feitosa Mary F, Graff Misa, Fisher Virginia A, Young Kristin, Barata Llilda, Deng Xuan, Czajkowski Jacek, Hadley David, Ngwa Julius S, Ahluwalia Tarunveer S, Chu Audrey Y, Heard-Costa Nancy L, Lim Elise, Perez Jeremiah, Eicher John D, Kutalik Zoltan, Xue Luting, Mahajan Anubha et al.. Nature Communications 8: 14977. 2017 -
New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals
Kraja Aldi T, Cook James P, Warren Helen R, Surendran Praveen, Liu Chunyu, Evangelou Evangelos, Mannig Alisa K, Grarup Niels, Drenos Fotios, Sim Xueling, Smith Albert Vernon, Amin Najaf, Blakemore Alexandra I F, Bork-Jensen Jette, Brandslund Ivan, Farmaki Aliki-Eleni, Fava Cristiano, Ferreira Teresa, Herzig Karl-Heinz, Giri Ayush et al.. Circulation: Cardiovascular Genetics 10 5: e001778. 2017 -
Physical activity, sedentary behaviour, and socioeconomic status among Finnish girls and boys aged 6 - 8 years
Lampinen Eeva-Kaarina, Eloranta Aino-Maija, Haapala Eero A, Lindi Virpi, Väistö Juuso, Lintu Niina, Karjalainen Panu, Kukkonen-Harjula Katriina, Laaksonen David, Lakka Timo A. European Journal of Sport Science 17 4: 462-472. 2017 -
Exome-wide association study of plasma lipids in >300,000 individuals
Liu DJ, Peloso GM, Yu H, Butterworth AS, Wang X, Mahajan A, Saleheen D, Emdin C, Alam D, Alves AC, Amouyel P, Di Angelantonio E, Arveiler D, Assimes TL, Auer PL, Baber U, Ballantyne CM, Bang LE, Benn M, Bis JC et al.. NATURE GENETICS 49 12: 1758-1766. 2017 -
Is there a duty to participate in a health research? A viewpoint of children 6-8 years of age and their parents
Länsimies H, Halkoaho A, Pietilä A-M, Lintu N, Kangasniemi M, Eloranta A-M, Viitasalo A, Lakka TA. International Diabetes Nursing 13 1-3: 49-54. 2017 -
A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk
Manning A, Highland HM, Gasser J, Sim X, Tukiainen T, Fontanillas P, Grarup N, Rivas MA, Mahajan A, Locke AE, Cingolani P, Pers TH, Viñuela A, Brown AA, Wu Y, Flannick J, Fuchsberger C, Gamazon ER, Gaulton KJ, Im HK et al. (incl. Lakka Timo, Kuulasmaa Teemu, Laakso Markku, Uusitupa Matti). DIABETES (NY) 66 7: 2019-2032. 2017 -
Rare and low-frequency coding variants alter human adult height
Marouli Eirini, Graff Mariaelisa, Medina-Gomez Carolina, Sin Lo Ken, Wood Andrew R, Kjaer Troels R, Fine Rebecca S, Lu Yingchang, Schurmann Claudia, Highland Heather M, Rüeger Sina, Thorleifsson Gudmar, Justice Anne E, Lamparter David, Stirrups Kathleen E, Turcot Valérie, Young Kristin L, Winkler Thomas W, Esko Tõnu, Karaderi Tugce et al. (incl Kuusisto Johanna, Laakso Markku, Lakka Timo A). Nature 542: 186-190. 2017 -
Associations of lifestyle factors with serum dehydroepiandrosterone sulfate and insulin-like growth factor-1 concentration in prepubertal children
Mäntyselkä A, Jääskeläinen J, Eloranta AM, Väistö J, Voutilainen R, Ong K, Brage S, Lakka TA, Lindi V. Clinical endocrinology 2018; 88 2: 234-242. 2017 -
Development of cortical motor circuits between childhood and adulthood: A navigated TMS-HdEEG study
Määttä S, Könönen M, Kallioniemi E, Lakka T, Lintu N, Lindi V, Ferreri F, Ponzo D, Säisänen L. HUMAN BRAIN MAPPING 38 5: 2599-2615. 2017 -
Genetic predisposition to adiposity is associated with increased objectively assessed sedentary time in young children
Schnurr TM, Viitasalo A, Eloranta AM, Damsgaard CT, Mahendran Y, Have CT, Väistö J, Hjorth MF, Christensen LB, Brage S, Atalay M, Lyytikäinen LP, Lindi V, Lakka T, Michaelsen KF, Kilpeläinen TO, Hansen T. INTERNATIONAL JOURNAL OF OBESITY 42: 111-114. 2017 -
Relation of oxygen uptake to work rate in prepubertal healthy children - reference for VO2/W-slope and effect on cardiorespiratory fitness assessment
Tompuri, Tuomo; Lintu, Niina; Laitinen, Tomi; Lakka, Timo A. CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING 2018; 38 4: 645-651. 2017 -
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T, Giri A, Graff M, Guo X, Hendricks AE, Karaderi T, Lempradl A, Locke AE, Mahajan A, Marouli E, Sivapalaratnam S, Young KL, Alfred T et al. (incl. Laakso Markku, Lakka Timo, Uusitupa Matti). NATURE GENETICS 50; 2018 1: 26-41. 2017 -
Determinants for craniofacial pains in children 6-8 years of age: the PANIC study
Vierola A, Suominen AL, Eloranta AM, Lintu N, Ikävalko T, Närhi M, Lakka T. ACTA ODONTOLOGICA SCANDINAVICA 75 6: 453-460. 2017 -
Maternal and fetal genetic contribution to gestational weight gain
Warrington NM, Richmond R, Fenstra B, Myhre R, Gaillard R, Paternoster L, Wang CA, Beaumont RN, Das S, Murcia M, Barton SJ, Espinosa A, Thiering E, Atalay M, Pitkänen N, Ntalla I, Jonsson AE, Freathy R, Karhunen V, Tiesler CMT et al. for the Early Growth Genetics (EGG) consortium. INTERNATIONAL JOURNAL OF OBESITY 42 4: 775-784. 2017 -
Prevalence and associated factors of abnormal liver values in children with celiac disease
Aarela Linnea, Nurminen Samuli, Kivela Laura, Huhtala Heini, Maki Markku, Viitasalo Anna, Kaukinen Katri, Lakka Timo, Kurppa Kalle. DIGESTIVE AND LIVER DISEASE 48 9: 1023-1029. 2016 -
Cross-sectional associations of objectively-measured physical activity and sedentary time with body composition and cardiorespiratory fitness in mid-childhood: the PANIC study
Collings Paul J, Westgate Kate, Väistö Juuso, Wijndaele Katrien, Atkin Andrew J, Haapala Eero A, Lintu Niina, Laitinen Tomi, Ekelund Ulf, Brage Soren, Lakka Timo A. SPORTS MEDICINE [Epub ahead of print 24 Aug 2016]: 1-12. 2016 -
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals
Ehret GB, Ferreira T, Chasman DI, Jackson AU, Schmidt EM, Johnson T, Thorleifsson G, Luan J, Donnelly LA, Kanoni S, Petersen AK, Pihur V, Strawbridge RJ, Shungin D, Hughes MF, Meirelles O, Kaakinen M, Bouatia-Naji N, Kristiansson K, Shah S et al.. NATURE GENETICS 48 10: 1171-1184. 2016 -
Dietary quality indices in relation to cardiometabolic risk among Finnish children aged 6-8 years - The PANIC study
Eloranta Aino-Maija, Schwab Ursula, Venäläinen Taisa, Kiiskinen Sanna, Lakka HM, Laaksonen David E, Lakka Timo A, Lindi Virpi. NUTRITION, METABOLISM AND CARDIOVASCULAR DISEASES 26 9: 833-841. 2016 -
Food sources of energy and nutrients in Finnish girls and boys 6-8 years of age - the PANIC study
Eloranta Aino-Maija, Venäläinen Taisa, Soininen Sonja, Jalkanen Henna, Kiiskinen Sanna, Schwab Ursula, Lakka Timo A, Lindi Virpi. FOOD & NUTRITION RESEARCH 60: 32444. 2016 -
Plasma polyunsaturated fatty acids are directly associated with cognition in overweight children but not in normal weight children
Haapala EA, Viitasalo A, Venäläinen T, Eloranta AM, Ågren J, Lindi V, Lakka TA. ACTA PAEDIATRICA 105 12: 1502-1507. 2016 -
Physical activity and sedentary time in relation to academicachievement in children
Haapala EA, Väistö J, Lintu N, Westgate K, Ekelund U, Poikkeus A-M, Brage S, Lakka TA. Journal of Science and Medicine in Sport 2017; 20 6: 583-589. 2016 -
Diet quality and academic achievement: a prospective study among primary school children
Haapala Eero A, Eloranta Aino-Maija, Venäläinen Taisa, Jalkanen Henna, Poikkeus Anna-Maija, Ahonen Timo, Lindi Virpi, Lakka Timo A. EUROPEAN JOURNAL OF NUTRITION 56 7: 2299-2308. 2016 -
Adiposity, physical activity and neuromuscular performance in children
Haapala Eero A, Vaisto, Juuso, Lintu Niina, Tompuri Tuomo, Brage Soren, Westgate Kate, Ekelund Ulf, Lampinen Eeva-Kaarina, Saakslahti Arja, Lindi Virpi, Lakka Timo A. Journal of Sports Sciences 34 18: 1699-706. 2016 -
Cardiorespiratory fitness and exercise-induced ST segment depression in assessing the risk of sudden cardiac death in men
Hagnäs MJ, Lakka TA, Kurl S, Rauramaa R, Mäkikallio TH, Savonen K, Laukkanen JA. Heart 103 5: 383-389. 2016 -
Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index
Hinney A, Kesselmeier M, Jall S, Volckmar AL, Föcker M, Antel J, Heid IM, Winkler TW, Grant SF, Guo Y, Bergen AW, Kaye W, Berrettini W, Hakonarson H, Herpertz-Dahlmann B, de Zwaan M, Herzog W, Ehrlich S, Zipfel S, Egberts KM et al., GCAN, WTCCC3, EGG, GIANT, Price Foundation Collaborative Group, Children's Hospital of Philadelphia/Price Foundation. MOLECULAR PSYCHIATRY 2017; 22: 192-201. 2016 -
Genome-wide associations for birth weight and correlations with adult disease
Horikoshi M, Beaumont RN, Day FR, Warrington NM, Kooijman MN, Fernandez-Tajes J, Feenstra B, van Zuydam NR, Gaulton KJ, Grarup N, Bradfield JP, Strachan DP, Li-Gao R, Ahluwalia TS, Kreiner E, Rueedi R, Lyytikäinen LP, Cousminer DL, Wu Y, Thiering E et al.. NATURE (LONDON) [Epub ahead of print 28 Sep 2016]: 1-20. 2016 -
Determinants of cardiorespiratory fitness in a population sample of girls and boys aged 6-8 years
Lintu Niina, Savonen Kai, Viitasalo Anna, Tompuri Timo, Paananen Jussi, Tarvainen Mika P, Lakka Timo. JOURNAL OF PHYSICAL ACTIVITY AND HEALTH [epub ahead of print]: 1-22. 2016 -
A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape
Ried JS, Jeff M J, Chu AY, Bragg-Gresham JL, van Dongen J, Huffman JE, Ahluwalia TS, Cadby G, Eklund N, Eriksson J, Esko T, Feitosa MF, Goel A, Gorski M, Hayward C, Heard-Costa NL, Jackson AU, Jokinen E, Kanoni S, Kristiansson K et al. Nature Communications 7: 13357. 2016 -
The genetic regulatory signature of type 2 diabetes in human skeletal muscle
Scott Laura J, Erdos Michael R, Huyghe Jeroen R, Welch Ryan P, Beck Andrew T, Wolford Brooke N, Chines Peter S, Didion John P, Narisu Narisu, Stringham Heather N, Taylor D Leeland, Jackson Anne U, Vadlamudi Swarooparani, Bonnycastle Bonny M, Kinnunen Leena, Saramies Jouko, Sundvall Jouko, D'Oliveira Albanus Ricardo, Kiseleva Anna, Hensley John et al (inc. LakkaTimo A, Laakso Markku). Nature Communications 7: 11764. 2016 -
Response: food fortification as a means to increase vitamin D intake
Soininen Sonja, Eloranta Aino-Maija, Lindi Virpi, Lakka Timo A. BRITISH JOURNAL OF NUTRITION 116 6: 1134-1135. 2016 -
Determinants of serum 25-hydroxyvitamin D concentration in Finnish children: the Physical Activity and Nutrition in Children (PANIC) study
Soininen Sonja, Eloranta Aino-Maija, Lindi Virpi, Venäläinen Taisa, Zaproudina Nina, Mahonen Anitta, Lakka Timo A. BRITISH JOURNAL OF NUTRITION 115 6: 1080-1091. 2016 -
Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension
Surendran P, Drenos F, Young R, Warren H, Cook JP, Manning AK, Grarup N, Sim X, Barnes DR, Witkowska K, Staley JR, Tragante V, Tukiainen T, Yaghootkar H, Masca N, Freitag DF, Ferreira T, Giannakopoulou O, Tinker A, Harakalova M et al. NATURE GENETICS 48: 1151-1161. 2016 -
Tieteelliset perusteet varhaisvuosien fyysisen aktiivisuuden suosituksille
Sääkslahti Arja, Muuronen Kaisu, Haapala Eero, Pulakka Anna, Haapala Henna, Lakka Timo A, Laukkanen Arto, Määttä Suvi, Reunamo Jyrki, Roos Eva, Soini Anne, Mäki Päivi, Iivonen Susanna, Asunta Piritta, Viholainen Helena, Ahonen Timo, Rintala Pauli, Cantell Marja, Kyhälä Anna-Liisa. 2016 2016 -
Comparison between parameters from maximal cycle ergometer test first without respiratory gas analysis and thereafter with respiratory gas analysis among healthy prepubertal children
Tompuri Tuomo T, Lintu Niina, Soininen Sonja, Laitinen Tomi, Lakka Timo A. APPLIED PHYSIOLOGY, NUTRITION AND METABOLISM 41 6: 624-630. 2016 -
Effect of a 2-y dietary and physical activity intervention on plasma fatty acid composition and estimated desaturase and elongase activities in children: the Physical Activity and Nutrition in Children Study
Venäläinen Taisa M, Viitasalo Anna M, Schwab Ursula S, Eloranta Aino-Maija, Haapala Eero A, Jalkanen Henna P, de Mello Vanessa DF, Laaksonen David E, Lindi Virpi I, Ågren Jyrki J, Lakka Timo A. AMERICAN JOURNAL OF CLINICAL NUTRITION 104 4: 964-972. 2016 -
Associations of Sedentary Behavior, Physical Activity, Cardiorespiratory Fitness, and Body Fat Content With Pain Conditions in Children: The Physical Activity and Nutrition in Children Study
Vierola Anu, Suominen Anna Liisa, Lindi Virpi, Viitasalo Anna, Ikävalko Tiina, Lintu Niina, Väistö Juuso, Kellokoski Jari, Närhi Matti, Lakka Timo A. JOURNAL OF PAIN 17 7: 845-853. 2016 -
Association of MBOAT7 gene variant with plasma ALT levels in children: The PANIC study
Viitasalo A, Eloranta A-M, Atalay M, Romeo S, Pihlajamäki J, Lakka TA. PEDIATRIC RESEARCH 80 5: 651-655. 2016 -
The Effects of a 2-year Individualized and Family-based Lifestyle Intervention on Physical Activity, Sedentary Behavior and Diet in Children
Viitasalo Anna, Eloranta Aino-Maija, Lintu Niina, Väistö Juuso, Venäläinen Taisa, Kiiskinen Sanna, Karjalainen Panu, Peltola Jaana, Lampinen Eeva-Kaarina, Haapala Eero A, Paananen Jussi, Schwab Ursula, Lindi Virpi, Lakka Timo A. PREVENTIVE MEDICINE 87: 81-88. 2016 -
Associations of TM6SF2 167K allele with liver enzymes and lipid profile in children: the PANIC Study
Viitasalo Anna, Pihlajamäki Jussi, Paananen Jussi, Atalay Mustafa, Lindi Virpi, Lakka Timo A. PEDIATRIC RESEARCH 79 5: 684-688. 2016 -
Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study
Winkler Thomas W, Justice Anne E, Graff Mariaelisa, Barata Llilda, Feitosa Mary F, Chu Su, Czajkowski Jacek, Esko Tõnu, Fall Tove, Kilpeläinen Tuomas O, Lu Yingchang, Mägi Reedik, Mihailov Evelin, Pers Tune H, Rüeger Sina, Teumer Alexander, Ehret Georg B, Ferreira Teresa, Heard-Costa Nancy L, Karjalainen Juha et al. PLOS GENETICS [ONLINE) 12 6: e1006166. 2016 -
Secular trends affect timing of emergence of permanent teeth
Eskeli Ritva, Lösönen Matias, Ikävalko Tiina, Myllykangas Riitta, Lakka Timo, Laine-Alava Maija T. ANGLE ORTHODONTIST Published Online: April 29, 2015: 6 p. 2015 -
Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index
Felix Janine F, Bradfield Jonathan P, Monnereau Claire, van der Valk Ralf JP, Stergiakouli Evie, Chesi Alessandra, Gaillard Romy, Feenstra Bjarke, Thiering Elisabeth, Kreiner-Møller Eskil, Mahajan Anubha, Pitkänen Niina, Joro Raimo, Cavadino Alana, Huikari Ville, Franks Steve, Groen-Blokhuis Maria M, Cousminer Diana L, Marsh Julie A, Lehtimäki Terho et al.; Early Growth Genetics (EGG) Consortium; . HUMAN MOLECULAR GENETICS (2016) 25 2: 389-403. 2015 -
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci
Gaulton KJ, Ferreira T, Lee Y, Raimondo A, Mägi R, Reschen ME, Mahajan A, Locke A, William Rayner N, Robertson N, Scott RA, Prokopenko I, Scott LJ, Green T, Sparso T, Thuillier D, Yengo L, Grallert H, Wahl S, Frånberg M et al.. NATURE GENETICS 47: 1415-1425. 2015 -
Associations of diet quality with cognition in children - the Physical Activity and Nutrition in Children Study
Haapala Eero A, Eloranta Aino-Maija, Venäläinen Taiisa, Schwab Ursula, Lindi Virpi, Lakka Timo A. BRITISH JOURNAL OF NUTRITION 114 07: 1080-1087. 2015 -
Associations of Physical Performance and Adiposity with Cognition in Children
Haapala Eero A, Lintu Niina, Väistö Juuso, Robinson Leah E, Viitasalo Anna, Lindi Virpi, Lakka Timo A. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE 47 10: 2166-2174. 2015 -
The value of cardiorespiratory fitness and exercise-induced ST segment depression in predicting death from coronary heart disease
Hagnas Magnus J., Kurl Sudhir, Rauramaa Rainer, Lakka Timo A., Makikallio Timo H., Savonen Kai, Laukkanen Jari A.. INTERNATIONAL JOURNAL OF CARDIOLOGY 196: 31-33. 2015 -
Lateral facial profile may reveal the risk for sleep disordered breathing in children - The PANIC-study
Ikävalko Tiina, Närhi Matti, Lakka Timo, Myllykangas Riitta, Tuomilehto Henri, Vierola Anu, Pahkala Riitta. ACTA ODONTOLOGICA SCANDINAVICA online April 20, 2015: 6 p. 2015 -
VO2max/kg is expected to be lower in obese individuals!
Krachler Benno, Savonen Kai, Komulainen Pirjo, Hassinen Maija, Lakka Timo A, Rauramaa Rainer. INTERNATIONAL JOURNAL OF CARDIOLOGY 189: 234. 2015 -
Cardiopulmonary fitness is a function of lean mass, not total body weight: The DR's EXTRA study
Krachler Benno, Savonen Kai, Komulainen Pirjo, Hassinen Maija, Lakka Timo A., Rauramaa Rainer. European Journal of Preventive Cardiology 22 9: 1171-1179. 2015 -
Obesity is an important source of bias in the assessment of cardiorespiratory fitness
Krachler Benno, Savonen Kai, Lakka Timo. AMERICAN HEART JOURNAL 170 5: e7-e8. 2015 -
Genetic studies of body mass index yield new insights for obesity biology
Locke Adam E, Kahali Bratati, Berndt Sonja I, Justice Anne E, Pers Tune H, Day Felix R, Powell Corey, Vedantam Sailaja, Buchkovich Martin L, Yang Jian, Croteau-Chonka Damien C, Esko Tonu, Fall Tove, Ferreira Teresa, Gustafsson Stefan, Kutalik Zoltán, Luan Jian'an, Mägi Reedik, Randall Joshua C, Winkler Thomas W et al. NATURE (LONDON) 518 7538: 197-206. 2015 -
Biological interpretation of genome-wide association studies using predicted gene functions
Pers Tune H, Karjalainen Juha M, Chan Yingleong, Westra Harm-Jan, Wood Andrew R, Yang Jian, Lui Julian C, Vedantam Sailaja, Gustafsson Stefan, Esko Tonu, Frayling Tim, Speliotes Elizabeth K, Genetic Investigation of ANthropometric Traits (GIANT) Consortium (incl. Johanna Kuusisto, Markku Laakso, Timo Lakka, Matti Uusitupa), Boehnke Michael, Raychaudhuri Soumya, Fehrmann Rudolf SN, Hirschhorn Joel . Nature Communications 6: 5890. 2015 -
Dietary Intake, FTO Genetic Variants, and Adiposity: A Combined Analysis of Over 16,000 Children and Adolescents
Qi Qibin, Downer Mary K, Kilpeläinen Tuomas O, Taal H Rob, Barton Sheila J, Ntalla Ioanna, Standl Marie, Boraska Vesna, Huikari Ville, Kiefte-de Jong Jessica C, Körner Antje, Lakka Timo A, Liu Gaifen, Magnusson Jessica, Okuda Masayuki, Raitakari Olli, Richmond Rebecca, Scott Robert A, Bailey Mark ES, Scheuermann Kathrin et al. DIABETES (NY) 64 7: 2467-2476. 2015 -
New genetic loci link adipose and insulin biology to body fat distribution
Shungin Dmitry, Winkler Thomas W, Croteau-Chonka Damien C, Ferreira Teresa, Locke Adam E, Mägi Reedik, Strawbridge Rona J, Pers Tune H, Fischer Krista, Justice Anne E, Workalemahu Tsegaselassie, Wu Joseph MW, Buchkovich Martin L, Heard-Costa Nancy L, Roman Tamara S, Drong Alexander W, Song Ci, Gustafsson Stefan, Day Felix R, Esko Tonu et al. NATURE (LONDON) 518 7538: 187-196. 2015 -
Motor cortical alterations in children with Asperger's syndrome studied with navigated TMS
Säisänen Laura, Könönen Mervi, Anttonen Meri, Niskanen Eini, Lintu Niina, Lindi Virpi, Lakka Timo, Vanninen Ritva, Makkonen Ismo, Julkunen Petro, Määttä Sara. Teoksessa: I Rektor (toim.), The 15th European congress on clinical neurophysiology. 2015 -
Associations of cardiorespiratory fitness, physical activity, and adiposity with arterial stiffness in children
Veijalainen A, Tompuri T, Haapala EA, Viitasalo , Lintu N, Väistö J, Laitinen T, Lindi V, Lakka TA. SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS [epub ahead of print 29 Jul 2015]: -. 2015 -
Cross-sectional associations of plasma fatty acid composition and estimated desaturase and elongase activities with cardiometabolic risk in Finnish children - The PANIC study
Venäläinen Taisa, Ågren Jyrki, Schwab Ursula, de Mello Vanessa D, Eloranta Aino-Maija, Laaksonen David E, Lindi Virpi, Lakka Timo A. Journal of Clinical Lipidology 2016; 10 1: 82-91. 2015 -
Association of plasma fatty acid composition with plasma irisin levels in normal weight and overweight/obese children
Viitasalo A, Ågren J, Venäläinen T, Pihlajamäki J, Jääskeläinen J, Korkmaz A, Atalay M, Lakka TA. PEDIATRIC OBESITY 2015; 11 4: 299-305. 2015 -
The 148 M allele of the PNPLA3 is associated with plasma irisin levels in a population sample of Caucasian children: The PANIC Study
Viitasalo Anna, Mustafa Atalay, Pihlajamäki Jussi, Jääskeläinen Jarmo, Korkmaz Ayhan, Kaminska Dorota, Lindi Virpi, Lakka Timo A.. METABOLISM 64 7: 793-796. 2015 -
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study
Winkler Thomas W, Justice Anne E, Graff Mariaelisa, Barata Llilda, Feitosa Mary F, Chu Su, Czajkowski Jacek, Esko Tõnu, Fall Tove, Kilpeläinen Tuomas O, Lu Yingchang, Mägi Reedik, Mihailov Evelin, Pers Tune H, Rüeger Sina, Teumer Alexander, Ehret Georg B, Ferreira Teresa, Heard-Costa Nancy L, Karjalainen Juha et al. PLOS GENETICS [ONLINE) 11 10: e1005378. 2015 -
Finger skin temperatures in 8- to 11-year-old children: determinants including physical characteristics and seasonal variation. The Physical Activity an Nutrition in Children (PANIC) Study
Zaproudina Nina, Närhi Matti, Veijalainen Aapo, Laitinen Tomi, Lakka Timo A. EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY [epub ahead of print 26 Nov 2015]: 1-9. 2015 -
Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty
Cousminer Diana L, Stergiakouli Evangelia, Berry Diane J, Ang Wei, Groen-Blokhuis Maria M, Körner Antje, Siitonen Niina, Ntalla Ioanna, Marinelli Marcella, Perry John RB, Kettunen Johannes, Jansen Rick, Surakka Ida, Timpson Nicholas J, Ring Susan, Mcmahon George, Power Chris, Wang Carol, Kähönen Mika, Jorma Viikari et. al.. HUMAN MOLECULAR GENETICS 23 16: 4451-64. 2014 -
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium, Asian Genetic Epidemiology Network Type 2 Diabetes (AGEN-T2D) Consortium, South Asian Type 2 Diabetes (SAT2D) Consortium, Mexican American Type 2 Diabetes (MAT2D) Consortium, Type 2 Diabetes Genetic Exploration by Nex-generation sequencing in multi-Ethnic Samples (T2D-GENES) Consortium, Mahajan A, Go MJ, Zhang W, Below JE, Gault. NATURE GENETICS 46 3: 234-244. 2014 -
Associations Of Cardiovascular Fitness, Motor Performance And Adiposity With Cognition In Children
Haapala Eero A, Tompuri Tuomo, Lintu Niina, Laitinen Tomi, Lindi Virpi, Lakka Timo A. 46(5):169. 2014 -
Correlates of Low Physical Activity Levels in Aging Men and Women: The DR's EXTRA Study
Hakola Leena, Hassinen Maija, Komulainen Pirjo, Lakka Timo A, Savonen Kai, Rauramaa Rainer. JOURNAL OF AGING AND PHYSICAL ACTIVITY Epub ahead of print: -. 2014 -
Moderators of Maintained Increase in Aerobic Exercise Among Aging Men and Women in a 4-year Randomized Controlled Trial: The DR's EXTRA Study
Hakola Leena, Savonen Kai, Komulainen Pirjo, Hassinen Maija, Rauramaa Rainer, Lakka Timo A. JOURNAL OF PHYSICAL ACTIVITY AND HEALTH -: -. 2014 -
Novel approach identifies SNPs in SLC2A10 and KCNK9 with evidence for parent-of-origin effect on body mass index
Hoggart Clive J, Venturini Giulia, Mangino Massimo, Gomez Felicia, Ascari Giulia, Zhao Jing Hua, Teumer Alexander, Winkler Thomas W, Tšernikova Natalia, Luan Jian'an, Mihailov Evelin, Ehret Georg B, Zhang Weihua, Lamparter David, Esko Tõnu, Macé Aurelian, Rüeger Sina, Bochud Pierre-Yves, Barcella Matteo, Dauvilliers Yves et al (including Atalay Mustafa, Kuusisto Johanna, Lakka Timo, Yaluri Alena, . PLOS GENETICS [ONLINE) 10 7: e1004508. 2014 -
Effects of extended-release niacin with laropiprant in high-risk patients
HPS2-THRIVE Collaborative Group, Landray MJ, Haynes R, Hopewell JC, Parish S, Aung T, Tomson J, Wallendszus K, Craig M, Jiang L, Collins R, Armitage J. NEW ENGLAND JOURNAL OF MEDICINE 371 3: 203-212. 2014 -
Cardiorespiratory fitness, respiratory function and hemodynamic responses to maximal cycle ergometer exercise test in girls and boys aged 9-11 years: the PANIC Study
Lintu Niina, Viitasalo Anna, Tompuri Tuomo, Veijalainen Aapo, Hakulinen Mikko, Laitinen Tomi, Savonen Kai, Lakka Timo A. EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY Epub ahead of print: -. 2014 -
Ennenaikaisen adrenarken sukupuolierot saattavat johtua erilaisesta kehon rasvakoostumuksesta
Mäntyselkä Aino, Jääskeläinen Jarmo, Lindi Virpi, Viitasalo Anna, Tompuri Tuomo, Voutilainen Raimo, Lakka Timo A. DUODECIM 130: 101. 2014 -
The presentation of adrenarche is sexually dimorphic and modified by body adiposity
Mäntyselkä Aino, Jääskeläinen Jarmo, Lindi Virpi, Viitasalo Anna, Tompuri Tuomo, Voutilainen Raimo, Lakka Timo A. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 99 10: 3889-3894. 2014 -
A Central Role for GRB10 in Regulation of Islet Function in Man
Prokopenko Inga, Poon Wenny, Mägi Reedik, Prasad BR, Salehi S Albert, Almgren Peter, Osmark Peter, Bouatia-Naji Nabila, Wierup Nils, Fall Tove, Stancáková Alena, Barker Adam, Lagou Vasiliki, Osmond Clive, Xie Weijia, Lahti Jari, Jackson Anne U, Cheng Yu-Ching, Liu Jie, O'Connell Jeffrey R et al. (including Kuusisto Johanna, Laakso Markku, Lakka Timo). PLOS GENETICS [ONLINE) 10 4: e1004235. 2014 -
Genome-wide Enrichment Analysis between Endometriosis and Obesity-related Traits Reveals Novel Susceptibility Loci
Rahmioglu Nilufer, Macgregor Stuart, Drong Alexander W, Hedman Åsa K, Harris Holly R, Randall Joshua C, Prokopenko Inga, The International EndoGene Consortium (IEC), The GIANT Consortium, Nyholt Dale R, Morris Andrew P, Montgomery Grant W, Missmer Stacey A, Lindgren Cecilia M, Zondervan Krina T. HUMAN MOLECULAR GENETICS Epub ahead of print: -. 2014 -
Normal values for heart rate variability parameters in children 6-8 years of age: The PANIC study
Seppälä S, Laitinen T, Tarvainen MP, Tompuri T, Veijalainen A, Savonen K, Lakka T. CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING 34(4): 290-296. 2014 -
Measures of cardiorespiratory fitness in relation to measures of body size and composition among children
Tompuri Tuomo, Lintu Niina, Savonen Kai, Laitinen Tomi, Laaksonen David, Jääskeläinen Jarmo, Lakka Timo A. CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING Epub ahead of print: -. 2014 -
A novel common variant in DCST2 is associated with length in early life and height in adulthood
van der Valk Ralf JP, Kreiner-Moller Eskil, Kooijman Marjolein N, Guxens Mònica, Stergiakouli Evangelia, Sääf Annika, Bradfield Jonatan P, Geller Frank, Geoffrey Hayes M, Cousminer Diana L, Körner Antje, Thiering Elisabeth, Curtin John A, Myhre Ronny, Huikari Ville, Joro Raimo, Kerkhof Marjan, Warrington Nicole M, Pitkänen Niina, Ntalla Ioanna et. al.. HUMAN MOLECULAR GENETICS Epub ahead of print: -. 2014 -
Cross-Sectional Associations of Food Consumption with Plasma Fatty Acid Composition and Estimated Desaturase Activities in Finnish Children
Venäläinen Taisa, Schwab Ursula, Ågren Jyrki, de Mello Vanessa, Lindi Virpi, Eloranta Aino-Maija, Kiiskinen Sanna, Laaksonen David, Lakka Timo A. LIPIDS 49 5: 467-479. 2014 -
Associations of I148M variant in PNPLA3 gene with plasma ALT levels during 2-year follow-up in normal weight and overweight children: the PANIC Study
Viitasalo A, Pihlajamaki J, Lindi V, Atalay M, Kaminska D, Joro R, Lakka TA. PEDIATRIC OBESITY - -[Epub ahead of print]. 2014 -
Validation of metabolic syndrome score by confirmatory factor analysis in children and adults and prediction of cardiometabolic outcomes in adults
Viitasalo Anna, Lakka Timo A, Laaksonen David E, Savonen Kai, Lakka Hanna-Maaria, Hassinen Maija, Komulainen Pirjo, Tompuri Tuomo, Kurl Sudhir, Laukkanen Jari A, Rauramaa Rainer. DIABETOLOGIA Epub ahead of print: -. 2014 -
Physical activity and sedentary behaviour in relation to cardiometabolic risk in children: cross-sectional findings from the Physical Activity and Nutrition in Children (PANIC) Study
Väistö J, Eloranta A-M, Viitasalo A, Tompuri T, Lintu N, Karjalainen P, Lampinen E-K, Ågren J, Laaksonen DE, Lakka H-M, Lindi V, Lakka TA. INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY 11 1: 55. 2014 -
Defining the role of common variation in the genomic and biological architecture of adult human height
Wood Andrew R, Esko Tonu, Yang Jian, Vedantam Sailaja, Pers Tune H, Gustafsson Stefan, Chu Audrey Y, Estrada Karol, Luan Jian'an, Kutalik Zoltán, Amin Najaf, Buchkovich Martin L, Croteau-Chonka Damien C, Day Felix R, Duan Yanan, Fall Tove, Fehrmann Rudolf, Ferreira Teresa, Jackson Anne U, Karjalainen Juha et.al.. NATURE GENETICS 46 11: 1173-86. 2014 -
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
Berndt SI, Gustafsson S, Mägi R, Ganna A, Wheeler E, Feitosa MF, Justice AE, Monda KL, Croteau-Chonka DC, Day FR, Esko T, Fall T, Ferreira T, Gentilini D, Jackson AU, Luan J, Randall JC, Vedantam S, Willer CJ, Winkler TW, et al. (including Atalay M, Kuusisto J, Lakka TA, Stancakova A, Laakso M, Uusitupa M). NATURE GENETICS 45 5: 501-512. 2013 -
Common variants associated with plasma triglycerides and risk for coronary artery disease
Do R, Willer CJ, Schmidt EM, Sengupta S, Gao C, Peloso GM, Gustafsson S, Kanoni S, Ganna A, Chen J, Buchkovich ML, Mora S, Beckmann JS, Bragg-Gresham JL, Chang H-Y, Demirkan A, Den Hertog HM, Donnelly LA, Ehret GB, Esko T et.al.. NATURE GENETICS 45 11: 1345-52. 2013 -
Dietary factors associated with metabolic risk score in Finnish children aged 6-8 years: the PANIC study
Eloranta AM, Lindi V, Schwab U, Kiiskinen S, Venäläinen T, Lakka HM, Laaksonen DE, Lakka TA. EUROPEAN JOURNAL OF NUTRITION online [Epub ahead of print]: -. 2013 -
Associations of motor and cardiovascular performance with academic skills in children
Haapala EA, Poikkeus A-M, Tompuri T, Kukkonen-Harjula K, Leppänen PHT, Lindi V, Lakka TA. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE online: x-x. 2013 -
Meta-analysis of gene-level associations for rare variants based on single-variant statistics
Hu Y-J, Berndt SI, Gustafsson S, Ganna A, Genetic Investigation of ANthropometric Traits (GIANT) Consortium (including M Atalay, T Lakka, J Kuusisto, M Laakso), Hirschhorn J, North KE, Ingelsson E, Lin D-Y et.al.. AMERICAN JOURNAL OF HUMAN GENETICS 93 2: 236-248. 2013 -
Cardiovascular fitness and haemodynamic responses to maximal cycle ergometer exercise test in children 6-8 years of age
Lintu N, Tompuri T, Viitasalo A, Soininen S, Laitinen T, Savonen K, Lindi V, Lakka TA. Journal of Sports Sciences online [Epub ahead of print]: -. 2013 -
Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits
Randall JC, Winkler TW, Kutalik Z, Berndt SI, Jackson AU, Monda KL, Kilpeläinen TO, Esko T, Mägi R, Li S, Workalemahu T, Feitosa MF, Croteau-Chonka DC, Day FR, Fall T, Ferreira T, Gustafsson S, Locke AE, Mathieson I, Scherag A, et al. (including J Kuusisto, M Laakso, M Atalay, T Lakka). PLOS GENETICS [ONLINE) 9 6: e1003500. 2013 -
Normal values for heart rate variability parameters in children 6-8 years of age: the PANIC Study
Seppälä S, Laitinen T, Tarvainen MP, Tompuri T, Veijalainen A, Savonen K, Lakka T. CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING Article first published online: -. 2013 -
Assessment of body composition by dual-energy X-ray absorptiometry, bioimpedance analysis and anthropometrics in children: the Physical Activity and Nutrition in Children study
Tompuri TT, Lakka TA, Hakulinen M, Lindi V, Laaksonen DE, Kilpeläinen TO, Jääskeläinen J, Lakka H-M, Laitinen T. CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING 2015; 35 1: 21-33. 2013 -
Lapsuusiän liikunnan merkitys - kardiometabolinen näkökulma
Valtonen M, Heinonen Olli J, Lakka Timo A, Tammelin T. DUODECIM 129 11: 1153-8. 2013 -
Metabolic risk factors are associated with stiffness index, reflection index and finger skin temperature in children
Veijalainen A, Tompuri T, Laitinen T, Lintu N, Viitasalo A, Laaksonen DE, Jääskeläinen J, Lakka TA. CIRCULATION JOURNAL 77 5: 1281-1288. 2013 -
Discovery and refinement of loci associated with lipid levels
Willer CJ, Schmidt EM, Sengupta S, Peloso GM, Gustafsson S, Kanoni S, Ganna A, Chen J, Buchkovich ML, Mora S, Beckmann JS, Bragg-Gresham JL, Chang H-Y, Demirkan A, Den Hertog HM, Do R, Donnelly LA, Ehret GB, Esko T, Feitosa MF et.al.. NATURE GENETICS 45 11: 1274-1283. 2013 -
Trans-Ethnic Fine-Mapping of Lipid Loci Identifies Population-Specific Signals and Allelic Heterogeneity That Increases the Trait Variance Explained
Wu Y, Waite LL, Jackson AU, Sheu WH, Buyske S, Absher D, Arnett DK, Boerwinkle E, Bonnycastle LL, Carty CL, Cheng I, Cochran B, Croteau-Chonka DC, Dumitrescu L, Eaton CB, Franceschini N, Guo X, Henderson BE, Hindorff LA, Kim E, et al. (including Stancakova A, Kuusisto J, Laakso M, Uusitupa M, Rauramaa R Lakka T.). PLOS GENETICS [ONLINE) 9 3: e1003379. 2013 -
Purchase of antidepressant agents by patients with type 1 diabetes is associated with increased mortality rates in women but not in men
Ahola AJ, Harjutsalo V, Saraheimo M, Forsblom C, Groop PH; FinnDiane Study Group.. DIABETOLOGIA 55 1: 73-79. 2012 -
A genome-wide association meta-analysis identifies new childhood obesity loci
Bradfield JP, Taal HR, Timpson NJ, Scherag A, Lecoeur C, Warrington NM, Hypponen E, Holst C, Valcarcel B, Thiering E, Salem RM, Schumacher FR, Cousminer DL, Sleiman PMA, Zhao J, Berkowitz RI, Vimaleswaran KS, Jarick I, Pennell CE, Evans DM et.al.. NATURE GENETICS 44 5: 526-531. 2012 -
Dietary factors associated with overweight and body adiposity in Finnish children aged 6-8 years: the PANIC study
Eloranta A-M, Lindi V, Schwab U, Tompuri T, Kiiskinen S, Lakka H-M, Laitinen T, Lakka TA. INTERNATIONAL JOURNAL OF OBESITY 36: 950-955. 2012 -
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism
Horikoshi M, Yaghootkar H, Mook-Kanamori DO, Sovio U, Taal HR, Hennig BJ, Bradfield JP, St Pourcain B, Evans DM, Charoen P, Kaakinen M, Cousminer DL, Lehtimäki T, Kreiner-Møller E, Warrington NM, Bustamante M, Feenstra B, Berry DJ, Thiering E et.al.. NATURE GENETICS - -: 1-10. 2012 -
Common variants at 6q22 and 17q21 are associated with intracranial volume
Ikram MA, Fornage M, Smith AV, Seshadri S, Schmidt R, Debette S, Vrooman HA, Sigurdsson S, Ropele S, Taal HR, Kanamori-Mook DO, Coker LH, Longstreth Jr WT, Niessen WJ, DeStefano AL, Beiser A, Zijdenbos AP, Struchalin M, Jack Jr CR, Rivadeneira F et.al.. NATURE GENETICS 44 5: 539-544. 2012 -
Craniofacial morphology but not excess body fat is associated with risk of having sleep-disordered breathing -The PANIC Study (a questionnaire-based inquiry in 6-8-year-olds)
Ikävalko T, Tuomilehto H, Pahkala R, Tompuri T, Laitinen T, Myllykangas R, Vierola A, Lindi V, Närhi M, Lakka TA. EUROPEAN JOURNAL OF PEDIATRICS 171 12: 1747-1752. 2012 -
Determinants of pain and functioning in hip osteoarthritis - a two-year prospective study
Juhakoski R, Malmivaara A, Lakka TA, Tenhonen S, Hannila M-L, Arokoski JPA. CLINICAL REHABILITATION online: -. 2012 -
Diet, fitness and metabolic syndrome - The DR's EXTRA Study
Kouki R, Schwab U, Lakka TA, Hassinen M, Savonen K, Komulainen P, Krachler B, Rauramaa R. NUTRITION, METABOLISM AND CARDIOVASCULAR DISEASES 22: 553-560. 2012 -
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
Manning AK, Hivert MF, Scott RA, Grimsby JL, Bouatia-Naji N, Chen H, Rybin D, Liu CT, Bielak LF, Prokopenko I, Amin N, Barnes D, Cadby G, Hottenga JJ, Ingelsson E, Jackson AU, Johnson T, Kanoni S, Ladenvall C, Lagou V et.al.. NATURE GENETICS 44 6: 659-669. 2012 -
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
Morris AP, Voight BF, Teslovich TM, Ferreira T, Segrè AV, Steinthorsdottir V, Strawbridge RJ, Khan H, Grallert H, Mahajan A, Prokopenko I, Kang HM, Dina C, Esko T, Fraser RM, Kanoni S, Kumar A, Lagou V, Langenberg C, Luan J et.al.. NATURE GENETICS 44 9: 981-990. 2012 -
Two-minute heart rate recovery after cycle ergometer exercise and all-cause mortality in middle-aged men
Savonen KP, Kiviniemi V, Laaksonen DE, Lakka TA, Laukkanen JA, Tuomainen T-P, Rauramaa R. JOURNAL OF INTERNAL MEDICINE 270: 589-596. 2012 -
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
Scott RA, Lagou V, Welch RP, Wheeler E, Montasser ME, Luan J, Mägi R, Strawbridge RJ, Rehnberg E, Gustafsson S, Kanoni S, Rasmussen-Torvik L, Yengo L, Lecoeur C, Shungin D, Sanna S, Sidore C, Johnson PCD, Jukema JW, Johnson T et.al.. NATURE GENETICS 44 9: 991-1005. 2012 -
Common variants at 12q15 and 12q24 are associated with infant head circumference
Taal HR, St Pourcain B, Thiering E, Das S, Mook-Kanamori DO, Warrington NM, Kaakinen M, Kreiner-Moller E, Bradfield JP, Freathy RM, Geller F, Guxens M, Cousminer DL, Kerkhof M, Timpson NJ, Ikram MA, Beilin LJ, Bonnelykke K, Buxton JL, Charoen P et.al.. NATURE GENETICS 44 5: 532-538. 2012 -
Low-grade inflammation and depressive symptoms as predictors of abdominal obesity
Valtonen MK, Laaksonen DE, Laukkanen JA, Tolmunen T, Viinamäki H, Lakka H-M, Lakka TA, Niskanen L, Kauhanen J. SCANDINAVIAN JOURNAL OF PUBLIC HEALTH 40 7: 674-680. 2012 -
Clinical signs of temporomandibular disorders and various pain conditions among children 6 to 8 years of age: The Panic Study
Vierola A, Suominen AL, Ikävalko T, Lintu N, Lindi V, Lakka H-M, Kellokoski J, Närhi M, Lakka TA. JOURNAL OF OROFACIAL PAIN 26 1: 17-25. 2012 -
Clustering of Metabolic Risk Factors Is Associated with High-Normal Levels of Liver Enzymes among 6- to 8-Year-Old Children: The PANIC Study
Viitasalo A, Laaksonen DE, Lindi V, Eloranta A-M, Jääskeläinen J, Tompuri T, Väisänen S, Lakka H-M, Lakka TA. METABOLIC SYNDROME AND RELATED DISORDERS 10 5: 337-343. 2012 -
Dietary factors and their associations with socioeconomic background in Finnish girls and boys 6-8 years of age: the PANIC Study
Eloranta AM, Lindi V, Schwab U, Kiiskinen S, Kalinkin M, Lakka HM, Lakka TA. EUROPEAN JOURNAL OF CLINICAL NUTRITION 65 11: 1211-8. 2011 -
Cardiorespiratory fitness in aging men and women: the DR's EXTRA study
Hakola L, Komulainen P, Hassinen M, Savonen K, Litmanen H, Lakka TA, Rauramaa R. SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS 21: 679-687. 2011 -
Liikunta. Käypä hoito -suositus
Kesäniemi A , Kettunen J, Ketola E, Kujala U, Kukkonen-Harjula K, Lakka T, Rauramaa R, Rauramo I, Tikkanen H, Vuori I. DUODECIM 127 2: 150-151. 2011 -
Physical activity attenuates the influence of FTO variants on obesity risk: A meta-analysis of 218,166 adults and 19,268 children
Kilpeläinen Tuomas O, Qi Lu, Brage Soren, Sharp Stephen J., Sonestedt Emily, Demerath Ellen, Ahmad Tariq, Mora Samia, Kaakinen Marika, Sandholt Camilla H, Holzapfel Christina, Autenrieth Christine S., Hyppönen Elina, Cauchi Stéphane , He Meian, Kutalik Zoltan, Kumari Meena, Stancaková Alena, Meidtner Karina, Balkau Beverley et al.. PLOS MEDICINE 8 11: e1001116. 2011 -
Food consumption, nutrient intake and the risk of having metabolic syndrome: the DR's EXTRA Study.
Kouki R, Schwab U, Hassinen M, Komulainen P, Heikkilä H, Lakka TA, Rauramaa R.. EUROPEAN JOURNAL OF CLINICAL NUTRITION 65: 368-377. 2011 -
Physical activity, body composition and sleep in children
Lintu N, Himanen A, Karjalainen P, Elonranta A-M, Tompuri T, Viitasalo A, Laitinen T, Tuomilehto H, Lakka H-M, Lindi V, Lakka T. Hakkarainen Anni, Liukkonen Jarmo, Linnamo Vesa, International congress on enhancement of physical activity of children and youth 2011. 45. 2011 -
Fine mapping of five loci associated with low-density lipoprotein cholesterol detects variants that double the explained heritability
Sanna S, Li B, Mulas A, Sidore C, Kang HM, Jackson AU, Grazia Piras M, Usala G, Maninchedda G, Sassu A, Serra F, Palmas MA, Wood III WH, Njølstad I, Laakso M, Hveem K, Tuomilehto J, Lakka TA, Rauramaa R, Boehnke M,et al.. PLOS GENETICS [ONLINE) 7: e1002198. 2011 -
The current standard measure of cardiorespiratory fitness introduces confounding by body mass: the DR's EXTRA study
Savonen K, Krachler B, Hassinen M, Komulainen P, Kiviniemi V, Lakka TA and Rauramaa R. INTERNATIONAL JOURNAL OF OBESITY 36 8: 1135-1140. 2011 -
Reproducibility of pulse contour analysis in children before and after maximal exercise stress test: The physical activity and nutrition in children (PANIC) study
Veijalainen A, Tompuri T, Lakka H-M, Laitinen T, & Lakka TA. CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING 31: 132-138. 2011 -
Cross-sectional analysis of baseline data to identify the major determinants of carotid intima-media thickness in a European population: the IMPROVE study
Baldassarre D, Nyyssönen K, Rauramaa R, de Faire U, Hamsten A, Smit AJ, Mannarino E, Humphries SE, Giral P, Grossi E, Veglia F, Paoletti R, Tremoli E; IMPROVE study group.. EUROPEAN HEART JOURNAL 614-22 5: 614-622. 2010 -
Lasten liikunta ja ravitsemus -tutkimus selvittää alakoululaisten elintapoja
Eloranta A-m, Lindi V, Schwab U, Kiiskinen S, Kalinkin M, Lintu N, Karjalainen P, Himanen A, Karjalainen J, Tompuri T, Viitasalo A, Lakka H-M, Lakka T & Lasten liikunta ja ravitsemus -tutkimus, Itä-Suomen yliopisto. BOLUS : RAVITSEMUSTERAPEUTTIEN YHDISTYKSEN LEHTI 4: 30-33. 2010 -
Cardiorespiratory fitness and metabolic syndrome in older men and women
Hassinen M, Lakka TA, Hakola L, Savonen K, Komulainen P, Litmanen H, Kiviniemi V, Kouki R, Heikkilä H, & Rauramaa R. DIABETES CARE 33 7: 1655-1657. 2010 -
Leisure-time physical activity and the metabolic syndrome in the Finnish diabetes prevention study
Ilanne-Parikka P, Laaksonen DE, Eriksson JG, Lakka TA, Lindström J, Peltonen M, Aunola S, Keinänen-Kiukaanniemi S, Uusitupa M & Tuomilehto J. On behalf of the Finnish diabetes prevention study group. DIABETES CARE 33 7: 1610-1617. 2010 -
Aikuisten liikunta
Kesäniemi A, Kettunen J, Ketola E, Kujala U, Kukkonen-Harjula K, Lakka T, Rauramaa R, Rauramo I, Tikkanen H & Vuori I. DUODECIM 126: 150-1. 2010 -
Exercise, fitness and cognition - A randomised controlled trial in older indivuals: The DR's EXTRA study
Komulainen P, Kivipelto M, Lakka TA, Savonen K, Hassinen M, Kiviniemi V, Hänninen T & Rauramaa R. European Geriatric Medicine 1: 266-272. 2010 -
Sedentary lifestyle and emergence of hopelessness in middle-aged men
Valtonen M, Laaksonen DE, Laukkanen J, Tolmunen T, Rauramaa R, Viinamäki H, Mursu J, Savonen K, Lakka TA, Niskanen L & Kauhanen J. EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION AND REHABILITATION 17 5: 524-9. 2010 -
Reproducibility of pulse contour analysis in children before and after maximal exercise stress test: The Physical Activity and Nutrition in Children (PANIC) Study
Veijalainen A, Tompuri T, Lakka HM, Laitinen T & Lakka TA. CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING online 2010 Nov 5: 1-7. 2010 -
Kardiorespiratorinen suorituskyky ja metabolinen oireyhtymä
Hassinen M, Savonen K, Lakka TA, Komulainen P, Litmanen H, Kiviniemi V, Kouki R, Heikkilä H, Hakola L, Rauramaa R. LIIKUNTA JA TIEDE 46 5: 34-35. 2009 -
Exercise and type 2 diabetes prevention
Hu G, Lakka TA, Barengo NC, Tuomilehto J. Teoksessa: Lignalli AT (toim.), Handbook of Type 2 Diabetes in the Middle Aged and Elderly [E-Book].Nova Science Publisher. ss. 93-111. 2009 -
Physical activity, fitness, and the preventioon of type 2 diabetes
Hu G, Lakka TA, Tuomilehto J. Teoksessa: Lee I-M (toim.), Epidemiologic Methods in Physical Avtivity Studies.Oxford University Press. ss. 201-224. 2009 -
Lasten ruokavaliossa on huolestuttavia piirteitä
Kiiskinen S, Schwab U, Kalinkin M, Lindi V, Tompuri T, Lakka H-M, Lakka T. SUOMEN LÄÄKÄRILEHTI 64: 144-145. 2009 -
Kardiorespiratorinen suorituskyky muistin ennustajana ikääntyneillä miehillä ja naisilla
Komulainen P, Savonen K, Litmanen H, Lakka TA, Kiviniemi V, Hassinen M, Kivipelto M, Hänninen T, Heikkilä H, Kouki R, Hakola L, Rauramaa R. LIIKUNTA JA TIEDE 46 5: 41. 2009 -
Determinants of cardiorespiratory fitness in men aged 42 to 60 years with and without cardiovascular disease
Laukkanen JA, Laaksonen D, Lakka TA, Savonen K, Rauramaa R, Mäkikallio T, Kurl S. AMERICAN JOURNAL OF CARDIOLOGY 103: 1598-1604. 2009 -
Leisure-time physical activity, cardiorespiratory fitness and feelings of hopelessness in men
Valtonen M, Laaksonen DE, Laukkanen J, Tolmunen T, Rauramaa R, Viinamäki H, Kauhanen J, Lakka T, Niskanen L. BMC PUBLIC HEALTH 9 204. 2009 -
Association of age and education with different types of leisure-time physical activity among 4437 Finnish adults
Borodulin K, Laatikainen T, Lahti-Koski M, Jousilahti P, Lakka TA. JOURNAL OF PHYSICAL ACTIVITY AND HEALTH 5 2: 242-251. 2008 -
Cardiorespiratory fitness as a feature of metabolic syndrome in older men and women
Hassinen M, Lakka TA, Savonen K, Litmanen H, Kiviaho L, Laaksonen DE, Komulainen P, Rauramaa R. DIABETES CARE 31 6: 1242-1247. 2008 -
Physical activity, fitness, and prevention of type 2 diabetes
Hu G, Lakka TA, Tuomilehto J. Lee IM, Epidemiologic Methods in Physical Activity Studies.Oxford University Press. 201-224. 2008 -
Interaction of single nucleotide polymorphisms in ADRB2, ADRB3, TNF, IL6, IGF1R, LIPC, LEPR, and GHRL with physical activity on the risk of type 2 diabetes mellitus and changes in characteristics of the metabolic syndrome. The Finnish Diabetes Prevention Study
Kilpeläinen TO, Lakka TA, Laakosnen DE, Mager U, Salopuro T, Kubaszek A, Todorova B, Laukkanen O, Lindström J, Eriksson JG, Hämäläinen H, Aunola S, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Laakso M, Uusitupa M. METABOLISM: CLINICAL AND EXPERIMENTAL 57: 428-436. 2008 -
SNPs in PPARG associte with type 2 diabetes and intract with physival activity
Kilpeläinen TO, Lakka TA, Laaksonen DE, Lindström J, Eriksson JG, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Lindi V, Tuomilehto J, Uusitupa M, Laakso M. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE 40: 25-33. 2008 -
BDNF is a novel marker of cognitive function in ageing women: the DR's EXTRA Study
Komulainen P, Pedersen M, Hänninen T, Bruunsgaard H, Lakka TA, Kivipelto M, Hassinen M, Rauramaa TH, Pedersen BK, Rauramaa R. NEUROBIOLOGY OF LEARNING AND MEMORY 90 4: 596-603. 2008 -
Dyslipidaemia as a predictor of hypertension in middle-aged men
Laaksonen DE, Niskanen L, Nyyssönen K, Lakka TA, Laukkanen JA, Salonen JT. EUROPEAN HEART JOURNAL 29: 2561-2568. 2008 -
Chronotropic incompetence and mortality in middle-aged men with known or suspected coronary heart disease
Savonen KP, Kiviniemi V, Laukkanen JA, Lakka TA, Rauramaa TH, Salonen JT, Rauramaa R. EUROPEAN HEART JOURNAL 29 15: 1896-1902. 2008 -
Usefulness of chronotropic incompetence in response to exercise as a predictor of myocardial infarction in middle-aged men without cardiovascular disease
Savonen KP, Lakka TA, Laukkanen JA, Rauramaa TH, Salonen JT, Rauramaa R. AMERICAN JOURNAL OF CARDIOLOGY 101: 992-998. 2008 -
Workload at the heart rate of 100 beats/min and mortality in middle-aged men known or suspected coronary heart disease
Savonen KP, Lakka TA, Laukkanen JA, Rauramaa TH, Salonen JT, Rauramaa R. Heart 94: E14. 2008 -
Physical activity and diabetes complications in patients with type 1 diabetes. The Finnish Diabetic Nephropathy (FinnDiane) Study
Wadén J, Forsblom C, Thorn LM, Saraheimo M, Rosengård-Bärlund M, Heikkilä O, Lakka TA, Tikkanen H, Groop PH, FinnDiane Study Group, Karhapää P, Laakso M, Moilanen L, Niskanen L, Vauhkonen I, Voutilainen E. DIABETES CARE 31: 230-232. 2008 -
Association of waist and hip circumference with 12-year progression of carotid intima-media thickness in elderly women
Hassinen M, Lakka TA, Komulainen P, Haapala I, Nissinen A, Rauramaa R. INTERNATIONAL JOURNAL OF OBESITY 31: 1406-1411. 2007 -
Occupational, commuting and leisure-time physical activity in relation to coronary heart disease among middle-aged Finnish men and women
Hu G, Jousilahti P, Borodulin K, Barengo NC, Lakka TA, Nissinen A, Tuomilehto J. ATHEROSCLEROSIS 194: 490-497. 2007 -
Epidemiological studies of exercise in diabetes prevention
Hu G, Lakka TA, Kilpeläinen T, Tuomilehto J. APPLIED PHYSIOLOGY, NUTRITION AND METABOLISM 32: 583-595. 2007 -
Obesity, physical activity, and nutrition in the metabolic syndrome
Hu G, Lakka TA, Lakka H-M, Tuomilehto J, Lakka TA. Teoksessa: Krentz AJ, Wong ND (toim.), Metabolic Syndrome and Cardiovascular Disease.Informa Healthcare. ss. 241-278. 2007 -
Physical activity modifies the effect of SNPs in the SLC2A2 (GLUT2) and ABCC8 (SUR1) genes on the risk of developing type 2 diabetes
Kilpeläinen TO, Lakka TA, Laaksonen DE, Laukkanen O, Lindström J, Eriksson JG, Valle TT, Hämäläinen H, Aunola S, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Uusitupa M, Laakso M, for the Finnish Diabetes Prevention Study Group, Laakso M. PHYSIOLOGICAL GENOMICS (PRINTED AND ONLINE) 31: 264-272. 2007 -
Carotid intima-media thickness and cognitive function in elderly women: a population-based study
Komulainen P, Kivipelto M, Lakka TA, Hassinen M, Helkala E-L, Patja K, Nissinen A, Rauramaa R. NEUROEPIDEMIOLOGY 28: 207-213. 2007 -
Metabolic syndrome and cognitive function: a population-based follow-up study in elderly women
Komulainen P, Lakka TA, Kivipelto M, Hassinen M, Helkala E-L, Haapala I, Nissinen A, Rauramaa R. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS 23: 29-34. 2007 -
Serum high sensitivity C-reactive protein and cognitive function in elderly women
Komulainen P, Lakka TA, Kivipelto M, Hassinen M, Penttilä IM, Helkala E-L, Gylling H, Nissinen A, Rauramaa R. AGE AND AGEING 36: 443-448. 2007 -
Physical activity in prevention and treatment of the metabolic syndrome
Lakka TA, Laaksonen DE. APPLIED PHYSIOLOGY, NUTRITION AND METABOLISM 32: 76-88. 2007 -
Effectiveness of workload at the heart rate of 100 beats/min in predicting cardiovascular mortality in men aged 42, 48, 54, or 60 years at baseline
Savonen KP, Lakka TA, Laukkanen JA, Rauramaa TH, Salonen JT, Rauramaa R. AMERICAN JOURNAL OF CARDIOLOGY 100: 563-568. 2007 -
Leisure-time physical activity is associated with the metaboic syndrome in type 1 diabetes: Effect of the PPAR-gamma Pro12Ala polymorphism: the FinnDiane Study
Wadén J, Thorn LM, Forsblom C, Lakka T, Saraheimo M, Rosengård-Bärlund M, Heikkilä O, Wessman M, Turunen JA, Parkkonen M, Tikkanen H, Groop P-H, on behalf of the FinnDiane Study Group. DIABETES CARE 30: 1618-1620. 2007 -
Different forms of physical activity and cardiovascular risk factors among 24-64-year-old men and women in Finland
Barengo NC, Kastarinen M, Lakka T, Nissinen A, Tuomilehto J. EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION AND REHABILITATION 13: 51-59. 2006 -
Association of leisure time physical activity abdomimal obesity with fsting serum insulin and 2-h postchallenge plasma glucose levels
Borodulin K, Tuomilehto J, Peltonen M, Lakka TA, Sundvall J, Jousilahti P. DIABETIC MEDICINE 23: 1025-1028. 2006 -
Metabolic syndrome and the progression of carotid intima-media thickness in elderly women
Hassinen M, Komulainen P, Lakka TA, Väisänen SB, Haapala I, Gylling H, Alen M, Schmidt-Trucksäss A, Nissinen A, Rauramaa R. ARCHIVES OF INTERNAL MEDICINE 166: 444-449. 2006 -
C-reactive protein and metabolic syndrome in elderly women. A 12-year follow-up study
Hassinen M, Lakka TA, Komulainen P, Gylling H, Nissinen A, Rauramaa R. DIABETES CARE 29: 931-932. 2006 -
Systemic immune mediators and lifestyle changes in the prevention of type 2 diabetes. Results from the Finnish diabes prevention study
Herder C, Peltonen M, Koenig W, Kräft I, Mûller-Scholze S, Martin S, Lakka T, Ilanne-Parikka P, Eriksson JG, Hämäläinen H, Keinänen-Kiukaanniemi S, Valle TT, Uusitupa M, Lindström J, Kolb H, Tuomilehto J. DIABETES (NY) 55: 2340-2346. 2006 -
Lifestyle management in the metabolic syndrome
Hu G, Lakka TA, Lakka H-M, Tuomilehto J. METABOLIC SYNDROME AND RELATED DISORDERS 4: 270-286. 2006 -
Exercise, genetics and prevention of type 2 diabetes
Hu G, Rico-Sanz J, Lakka TA, Tuomilehto J. ESSAYS IN BIOCHEMISTRY 42: 177-192. 2006 -
The TNF-a G-308A polymorphism is associated with C-reactive protein levels: The HERITAGE Family Study
Lakka H-M, Lakka TA, Rankinen T, Rice T, Rao DC, Leon AS, Skinner JS, Bouchard C. VASCULAR PHARMACOLOGY 44: 377-383. 2006 -
Letter to the editor (Exercise and inflammation: reply)
Lakka TA, Lakka H-M, Rankinen T, Bouchard C. 2006. Letter to the editor (Exercise and inflammation; reply). EUROPEAN HEART JOURNAL 27 11: 1385- 2006 -
Quantitative trait locus on chromosme 20q13 for plasma levels of C-reactive protein in healthy whites: the HERITAGE family sudy
Lakka TA, Rankinen T, Rice T, Leon AS, Rao DC, Skinner JS, Bouchard C. PHYSIOLOGICAL GENOMICS (PRINTED AND ONLINE) 27: 103-107. 2006 -
Peak oxygen pulse during exercise as a predictor for coronary heart disease and all cause death
Laukkanen JA, Kurl S, Salonen JT, Lakka TA, Rauramaa R. HEART 92 9: 1219-1224. 2006 -
Heart rate response during exercise test and cardiovascular mortality in middle-aged men
Savonen KP, Lakka TA, Laukkanen JA, Halonen PM, Rauramaa TH, Salonen JT, Rauramaa R. EUROPEAN HEART JOURNAL 27: 582-588. 2006 -
High dietary methionine intake increases the risk of acute coronary events in middle-aged men
Virtanen JK, Voutilainen S, Rissanen TH, Happonen P, Mursu J, Laukkanen JA, Poulsen H, Lakka TA, Salonen JT. NUTRITION, METABOLISM AND CARDIOVASCULAR DISEASES 16: 113-120. 2006 -
Low physical activity as a predictor for antihypertensive drug treatment in 25- 64-year-old populations in Eastern and south-western Finland
Barengo NC, Hu G, Kastarinen M, Lakka TA, Pekkarinen H, Nissinen A, Tuomilehto J. JOURNAL OF HYPERTENSION 23: 293-299. 2005 -
Associations between estimated aerobic fitness and cardiovascular risk factors in adults with different levels of abdominal obesity
Borodulin K, Laatikainen T, Lahti-Koski M, Lakka TA, Laukkanen R, Sarna S, Jousilahti P. EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION AND REHABILITATION 12 1: 126-131. 2005 -
Effects of exercise training on glucose homeostasis. The Heritage family studies
Boulé NG, Weisnagel SJ, Lakka TA, Tremblay A, Bergman RN, Rankinen T, Leon AS, Skinner JS, Wilmore JH, Rao DC, Bouchard C. DIABETES CARE 28 1: 108-114. 2005 -
Associations of body composition and physical activity with balance and walking ability in the elderly
Hassinen M, Komulainen P, Lakka TA, Väisänen SB, Rauramaa R. JOURNAL OF PHYSICAL ACTIVITY AND HEALTH 3: 298-306. 2005 -
Physical activity, cardiovascular risk factors, and mortality among Finnish adults with diabetes
Hu G, Jousilahti P, Barengo NC, Qiao Q, Lakka TA, Tuomilehto J. DIABETES CARE 28 4: 799-805. 2005 -
Physical activity in the prevention of type 2 diabetes. The Finnish diabetes prevention study
Laaksonen DE, Lindström J, Lakka TA, Eriksson JG, Niskanen L, Wikström K, Aunola S, Keinänen-Kiukaanniemi S, Laakso M, Valle TT, Ilanne-Parikka P, Louheranta A, Hakumäki M, Kaikkonen H, Härkönen P, Sundvall J, Tuomilehto J, Uusitupa M, Louheranta A. DIABETES (NY) 54: 158-165. 2005 -
Effect of exercise training on plasma levels of C-reactive protein in healthy adults: the HERITAGE family study
Lakka TA, Lakka H-M, Rankinen T, Leon AS, Rao DC, Skinner JS, Wilmore JH, Bouchard C. EUROPEAN HEART JOURNAL 26: 2018-2025. 2005 -
Protein tyrosine phosphatase 1B variant associated with fat distribution and insulin metabolism
Ukkola O, Rankinen T, Lakka T, Leon AS, Skinner JS, Wilmore JH, Rao DC, Kesäniemi YA, Bouchard C. OBESITY (SILVER SPRING, MD.) 13 5: 829-834. 2005 -
Low physical activity as a predictor for total and cardiovascular disease mortality in middle-aged men and women in Finland
Barengo NC, Hu G, Lakka TA, Pekkarinen H, Nissinen A, Tuomilehto J. EUROPEAN HEART JOURNAL 25: 2204-2211. 2004 -
Relationship of physical activity and body mass index to the risk of hypertension: a prospective study in Finland
Hu G, Barengo NC, Tuomilehto J, Lakka TA, Nissinen A, Jousilahti P. HYPERTENSION 43: 25-30. 2004 -
Physical activity in the prevention of type 2 diabetes
Hu G, Lakka TA, Barengo NC, Tuomilehto J. KARDIOVASKULÄRE MEDIZIN 7 11: 394-405. 2004 -
Epidemiology and treatment of the metabolic syndrome
Laaksonen DE, Niskanen L, Lakka H-M, Lakka TA, Uusitupa M, Laaksonen DE. Annals of Medicine 36: 332-346. 2004 -
Systolic blood pressure during recovery from exercise and the risk of acute myocardial infarction in middle-aged men
Laukkanen JA, Kurl S, Salonen R, Lakka TA, Rauramaa R, Salonen JT. HYPERTENSION 44: 820-825. 2004 -
Cardiorespiratory fitness and vigorous leisure-time physical activity modify the association of small size at birth with the metabolic syndrome
Laaksonen DE, Lakka H-M, Lynch J, Lakka TA, Niskanen L, Rauramaa R, Salonen JT, Kauhanen J. DIABETES CARE 26 7: 2156-2164. 2003 -
Sedentary lifestyle, poor cardiorespiratory fitness, and the metabolic syndrome
Lakka TA, Laaksonen DE, Lakka H-M, Männikkö N, Niskanen LK, Rauramaa R, Salonen JT. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE 35 8: 1279-1286. 2003 -
Abdominal obesity is associated with accelerated progression of carotid atherosclerosis in men
Lakka TA, Lakka H-M, Salonen R, Kaplan GA, Salonen JT. ATHEROSCLEROSIS 154: 497-504. 2001 -
Cardiovascular fitness as a predictor of mortality in men
Laukkanen JA, Lakka TA, Rauramaa R, Kuhanen R, Venäläinen JM, Salonen R, Salonen JT. ARCHIVES OF INTERNAL MEDICINE 161: 825-831. 2001 -
Leisure-time physical activity and rate of bone loss among peri- and postmenopausal women: a longitudinal study
Puntila E, Kröger H, Lakka T, Tuppurainen M, Jurvelin J, Honkanen R. BONE 29 5: 442-446. 2001 -
Liikuntaa sepelvaltimotaudin ehkäisyyn ja hoitoon
Rauramaa R, Lakka TA. DUODECIM 117: 633-638. 2001 -
Risk of acute coronary events and serum concentration of asymmetrical dimethylarginine
Valkonen V-P, Päivä H, Salonen JT, Lakka TA, Lehtimäki T, Laakso J, Laaksonen R. LANCET 358: 2127-2128. 2001 -
Low dietary folate intake is associated with an excess incidence of acute coronary events. The Kuopio Ischemic Heart Disease Risk Factor Study
Voutilainen S, Rissanen TH, Virtanen J, Lakka TA, Salonen JT. CIRCULATION 103: 2674-2680. 2001 -
Low serum folate concentrations are associated with an excess incidence of acute coronary events: the Kuopio Ischaemic Heart Disease Risk Factor Study
Voutilainen S, Lakka TA, Porkkala-Sarataho E, Rissanen T, Kaplan GA, Salonen JT. EUROPEAN JOURNAL OF CLINICAL NUTRITION 54: 424-428. 2000 -
Risk of acute coronary events according to serum concentrations of enterolactone: a prospective population-based case-control study
Vanharanta M, Voutilainen S, Lakka TA, van der Lee M, Adlercreutz H, Salonen JT. LANCET 354: 2112-2115. 1999 -
Weight gain and the risk of developing insulin resistance syndrome
Everson SA, Goldberg DE, Helmrich SP, Lakka TA, Lynch JW, Kaplan GA, Salonen JT. DIABETES CARE 21: 1637-1643. 1998 -
Hyperinsulinemia is associated with the incidence of hypertension and dyslipidemia in middle-aged men
Salonen JT, Lakka TA, Lakka H-M, Valkonen V-P, Everson SA, Kaplan GA. DIABETES (NY) 47: 270-275. 1998 -
Frequent hangovers and cardiovascular mortality in middle-aged men
Kauhanen J, Kaplan GA, Goldberg DD, Cohen RD, Lakka TA, Salonen JT. EPIDEMIOLOGY 8: 310-314. 1997 -
The physical activity questionnaires of the Kuopio Ischemic Heart Disease Risk Factor Study (KIHD)
Lakka TA, Salonen JT. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE. SUPPLEMENT 29 6: S46-S58. 1997 -
Physical activity in adolescence and bone density in peri- and postmenopausal women: A population-based study
Puntila E, Kröger H, Lakka T, Honkanen R, Tuppurainen M. BONE 21: 363-367. 1997 -
Body iron stores are associated with serum insulin and blood glucose concentrations
Tuomainen T-P, Nyyssönen K, Salonen R, Tervahauta A, Korpela H, Lakka T, Kaplan GA, Salonen JT. DIABETES CARE 20 3: 426-428. 1997 -
Conditioning leisure time physical activity and cardiorespiratory fitness in sociodemographic groups of middle-aged men in Eastern Finland
Lakka TA, Kauhanen J, Salonen JT. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY 25 1: 86-93. 1996 -
Hyperinsulinemia and the risk of coronary heart disease
Lakka TA, Lakka H-M, Salonen JT. NEW ENGLAND JOURNAL OF MEDICINE 335 13: 976-977. 1996 -
Moderately intense physical activities and high levels of cardiorespiratory fitness reduce the risk of non-insulin-dependent diabetes mellitus in middle-aged men
Lynch J, Helmrich SP, Lakka TA, Kaplan GA, Cohen RD, Salonen R, Salonen JT. ARCHIVES OF INTERNAL MEDICINE 156: 1307-1314. 1996 -
Religious affiliation and all-cause mortality: a prospective population study in middle-aged men in Eastern Finland
Räsänen J, Kauhanen J, Lakka TA, Kaplan GA, Salonen JT. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY 25 6: 1244-1249. 1996 -
Higher levels of conditioning leisure time physical activity are associated with reduced levels of stored iron in Finnish men
Lakka TA, Nyyssönen K, Salonen JT. AMERICAN JOURNAL OF EPIDEMIOLOGY 140: 148-160. 1994 -
Relation of leisure-time physical activity and cardiorespiratory fitness to the risk of acute myocardial infarction in men
Lakka TA, Venäläinen JM, Rauramaa R, Salonen R, Tuomilehto J, Salonen JT. NEW ENGLAND JOURNAL OF MEDICINE 330: 1549-1554. 1994