Timo Lakka

Accelerated early childhood growth associates with the development of earlier adrenarche and puberty

Liimatta, Jani; Jääskeläinen, Jarmo; Mäntyselkä, Aino; Häkkinen, Merja R; Auriola, Seppo; Voutilainen, Raimo; Flück, Christa E; Lakka, Timo A. 2024. Journal of the Endocrine Society. 8: . bvae026

Accumulating Sedentary Time and Physical Activity From Childhood to Adolescence and Cardiac Function in Adolescence

Haapala, Eero A; Leppänen, Marja H; Lee, Earric; Savonen, Kai; Laukkanen, Jari A; Kähönen, Mika; Brage, Soren; Lakka, Timo A. 2024. Journal of the american heart association: Cardiovascular and cerebrovascular disease. 13:

Associations of Lifestyle Patterns with Glucose and Lipid Metabolism in Finnish Adults at Increased Risk of Type 2 Diabetes

Manninen, Suvi; Tilles‐Tirkkonen, Tanja; Aittola, Kirsikka; Männikkö, Reija; Karhunen, Leila; Kolehmainen, Marjukka; Schwab, Ursula; Lindström, Jaana; Lakka, Timo; Pihlajamäki, Jussi; the Stop Diabetes study group. 2024. Molecular nutrition and food research. [Epub ahead of print 2 Feb 2024]: 1-12

Luonnossa vietetyn ajan ja liikunnan yhteydet positiiviseen mielenterveyteen työelämän ulkopuolella olevilla pohjoissavolaisilla

Rekola, Hanna; Kurkinen, Karoliina; Tolmunen, Tommi; Pentikäinen, Heikki; Lakka, Timo A; Mäki-Opas, Tomi. 2024. Liikunta ja tiede. 61: 105-111

Maternal gestational hypertension, smoking and pre‐eclampsia are associated with metabolic dysfunction‐associated fatty liver disease in overweight offspring

de Ruyter, Hanna; Aitokari, Linnea; Lahti, Siiri; Riekki, Hanna; Huhtala, Heini; Lakka, Timo; Laivuori, Hannele; Kurppa, Kalle. 2024. Acta obstetricia et gynecologica scandinavica. [Epub ahead of print 3 Mar 2024]: 1-9

Prenatal Urban Environment and Blood Pressure Trajectories From Childhood to Early Adulthood

Gonçalves Soares, Ana; Santos, Susana; Seyve, Emie; Nedelec, Rozenn; Puhakka, Soile; Eloranta, Aino-Maija; Mikkonen, Santtu; Yuan, Wen Lun; Lawlor, Deborah A.; Heron, Jon; Vrijheid, Martine; Lepeule, Johanna; Nieuwenhuijsen, Mark; Fossati, Serena; Jaddoe, Vincent W.V.; Lakka, Timo; Sebert, Sylvain; Heude, Barbara; Felix, Janine F.; Elhakeem, Ahmed; Timpson, Nicholas J.. 2024. JACC : advances. 3:

The associations of depressive symptoms and perceived stress with arterial health in adolescents

Toivonen, Emmi; Lee, Earric; Leppänen, Marja H; Laitinen, Tomi; Kähoenen, Mika; Lakka, Timo A; Haapala, Eero A. 2024. Physiological reports. 12:

Alanine aminotransferase cutoffs for the pediatric fatty liver disease: Major impact of the reference population

Aitokari, Linnea; Lahti, Siiri; Kivelä, Laura; Riekki, Hanna; Hiltunen, Pauliina; Vuorela, Nina; Viitasalo, Anna; Soininen, Sonja; Huhtala, Heini; Lakka, Timo; Kurppa, Kalle. 2023. Journal of pediatric gastroenterology and nutrition. [Epub ahead of print 10 Dec 2023]: 1-9

Associations Between Engagement with the BitHabit Digital Lifestyle Intervention and Changes in Type 2 Diabetes Risk Factors

Liedes, Hilkka; Mattila, Elina; Honka, Anita; Absetz, Pilvikki; Aittola, Kirsikka; Manninen, Suvi; Lintu, Niina; Schwab, Ursula; Eloranta, Aino-Maija; Umer, Adil; Tilles-Tirkkonen, Tanja; Männikkö, Reija; Ruotsalainen, Ilona; Van Gils, Mark; Lindström, Jaana; Lakka, Timo; Pihlajamäki, Jussi; Vuorinen, Anna-Leena. 2023. Studies in health technology and informatics

Associations between physical fitness and cerebellar gray matter volume in adolescents

Jalanko, Petri; Säisänen, Laura; Kallioniemi, Elisa; Könönen, Mervi; Lakka, Timo A; Määttä, Sara; Haapala, Eero A. 2023. Scandinavian journal of medicine and science in sports. 2024; 34:

Associations of diet quality and food consumption with serum biomarkers for lipid and amino acid metabolism in Finnish children: the PANIC study

Laamanen, Suvi E; Eloranta, Aino Maija; Haapala, Eero A; Sallinen, Taisa; Schwab, Ursula; Lakka, Timo A. 2023. European journal of nutrition. 2024; 63: 623-637

Bone mineral density loci specific to the skull portray potential pleiotropic effects on craniosynostosis

Medina-Gomez, Carolina; Mullin, Benjamin H.; Chesi, Alessandra; Prijatelj, Vid; Kemp, John P.; Shochat-Carvalho, Chen; Trajanoska, Katerina; Wang, Carol; Joro, Raimo; Evans, Tavia E.; Schraut, Katharina E.; Li-Gao, Ruifang; Ahluwalia, Tarunveer S.; Zillikens, M. Carola; Zhu, Kun; Mook-Kanamori, Dennis O.; Evans, Daniel S.; Nethander, Maria; Knol, Maria J.; Thorleifsson, Gudmar; Prokic, Ivana; Zemel, Babette; Broer, Linda; McGuigan, Fiona E.; van Schoor, Natasja M.; Reppe, Sjur; Pawlak, Mikolaj A. 2023. Communications biology. 6:

Cross-Lagged Associations between Physical Activity, Motor Performance, and Academic Skills in Primary-School Children

Haapala, Eero A; Widlund, Anna; Poikkeus, Anna-Maija; Lima, Rodrigo Antunes; Brage, Soren; Aunio, Pirjo; Lakka, Timo A. 2023. Medicine and science in sports and exercise. 55: 1465-1470

Cross-sectional associations between physical fitness and biomarkers of inflammation in children—The PANIC study

Haapala, Eero A; Kuronen, Emmi; Ihalainen, Johanna K; Lintu, Niina; Leppänen, Marja H; Tompuri, Tuomo; Atalay, Mustafa; Schwab, Ursula; Lakka, Timo A. 2023. Scandinavian journal of medicine and science in sports. 33: 1000-1009

Developmental models of motor-evoked potential features by transcranial magnetic stimulation across age groups from childhood to adulthood

Nguyen, Dao T A; Julkunen, Petro; Säisänen, Laura; Määttä, Sara; Rissanen, Saara M; Lintu, Niina; Könönen, Mervi; Lakka, Timo; Karjalainen, Pasi A. 2023. Scientific reports. 13:

Digitaalisella hyvinvointisovelluksella voidaan mitata mielen hyvinvointia ja elintapoja sekä toteuttaa näiden edistämistä tukevia interventioita

Rekola, Hanna; Sveins, Petteri; Tenhunen, Juha; Strömmer, Juho; Borgström, Joni; Paronen, Elsa; Surakka, Anne; Saijonkari, Maija; Pentikäinen, Heikki; Lakka, Timo; Mäki-Opas, Tomi. 2023. . . Itä-Suomen yliopisto

Effects of 2-Year Physical Activity and Dietary Intervention on Adrenarchal and Pubertal Development: The PANIC Study

Liimatta, Jani; Flück, Christa E; Mäntyselkä, Aino; Häkkinen, Merja R; Auriola, Seppo; Voutilainen, Raimo; Jääskelainen, Jarmo; Lakka, Timo A. 2023. Journal of clinical endocrinology and metabolism. 108: e1603-e1613

Effects of 2‐year dietary and physical activity intervention on cognition in children—a nonrandomized controlled trial

Naveed, Sehrish; Sallinen, Taisa; Eloranta, Aino‐Maija; Skog, Hannamari; Jalkanen, Henna; Brage, Soren; Ekelund, Ulf; Pentikäinen, Heikki; Savonen, Kai; Lakka, Timo A.; Haapala, Eero A.. 2023. Scandinavian journal of medicine and science in sports. 33: 2340-2350

European fitness landscape for children and adolescents: updated reference values, fitness maps and country rankings based on nearly 8 million test results from 34 countries gathered by the FitBack network

Ortega, Francisco B; Leskošek, Bojan; Blagus, Rok; Gil-Cosano, José J; Mäestu, Jarek; Tomkinson, Grant R; Ruiz, Jonatan R; Mäestu, Evelin; Starc, Gregor; Milanovic, Ivana; Tammelin, Tuija H; Sorić, Maroje; Scheuer, Claude; Carraro, Attilio; Kaj, Mónika; Csányi, Tamás; Sardinha, Luis B; Lenoir, Matthieu; Emeljanovas, Arunas; Mieziene, Brigita; Sidossis, Labros S; Pihu, Maret; Lovecchio, Nicola; Konstabel, Kenn; Tambalis, Konstantinos D; Štefan, Lovro; Drenowatz, Clemens; Rubín, Lukáš; Gontarev, S. 2023. British journal of sports medicine. 57: 299-310

Evidence for protein leverage in a general population sample of children and adolescents

Saner, Christoph; Senior, Alistair M; Zhang, Hanyue; Eloranta, Aino-Maija; Magnussen, Costan G; Sabin, Matthew A; Juonala, Markus; Janner, Marco; Burgner, David P; Schwab, Ursula; Haapala, Eero A; Heitmann, Berit L; Simpson, Stephen J; Raubenheimer, David; Lakka, Timo A. 2023. European journal of clinical nutrition. 77: 652-659

Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci

de las Fuentes, Lisa; Schwander, Karen L; Brown, Michael R; Bentley, Amy R; Winkler, Thomas W; Sung, Yun Ju; Munroe, Patricia B; Miller, Clint L; Aschard, Hugo; Aslibekyan, Stella; Bartz, Traci M; Bielak, Lawrence F; Chai, Jin Fang; Cheng, Ching-Yu; Dorajoo, Rajkumar; Feitosa, Mary F; Guo, Xiuqing; Hartwig, Fernando P; Horimoto, Andrea; Kolčić, Ivana; Lim, Elise; Liu, Yongmei; Manning, Alisa K; Marten, Jonathan; Musani, Solomon K; Noordam, Raymond; Padmanabhan, Sandosh; Rankinen, Tuomo; Richard,. 2023. Frontiers in genetics. 14: . 1235337

Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake

Williamson, Alice; Norris, Dougall M.; Yin, Xianyong; Broadaway, K. Alaine; Moxley, Anne H.; Vadlamudi, Swarooparani; Wilson, Emma P.; Jackson, Anne U.; Ahuja, Vasudha; Andersen, Mette K.; Arzumanyan, Zorayr; Bonnycastle, Lori L.; Bornstein, Stefan R.; Bretschneider, Maxi P.; Buchanan, Thomas A.; Chang, Yi-Cheng; Chuang, Lee-Ming; Chung, Ren-Hua; Clausen, Tine D.; Damm, Peter; Delgado, Graciela E.; de Mello, Vanessa D.; Dupuis, Josée; Dwivedi, Om P.; Erdos, Michael R.; Silva, Lilian Fernandes; F. 2023. Nature genetics. 55: 973-983

Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth

Beaumont, Robin N.; Flatley, Christopher; Vaudel, Marc; Wu, Xiaoping; Chen, Jing; Moen, Gunn-Helen; Skotte, Line; Helgeland, Øyvind; Solé-Navais, Pol; Banasik, Karina; Albiñana, Clara; Ronkainen, Justiina; Fadista, João; Stinson, Sara Elizabeth; Trajanoska, Katerina; Wang, Carol A.; Westergaard, David; Srinivasan, Sundararajan; Sánchez-Soriano, Carlos; Bilbao, Jose Ramon; Allard, Catherine; Groleau, Marika; Kuulasmaa, Teemu; Leirer, Daniel J.; White, Frédérique; Jacques, Pierre-Étienne; Cheng, H. 2023. Nature genetics. 55: 1807-1819

Impaired cardiorespiratory and neuromuscular fitness in children and adolescents with juvenile idiopathic arthritis: a cross-sectional case-control study in the era of biologic drug therapies

Räsänen, Kati; Markula-Patjas, Kati; Kantanen, Saija; Sipilä, Kalle; Lakka, Timo A.; Arikoski, Pekka; Piippo-Savolainen, Eija. 2023. Pediatric rheumatology. 21:

Parempaa mielenterveyden edistämistä Pohjois-Savossa kuntien mielenterveysjohtamisen käsitettä ja tavoitteita täsmentämällä sekä tiedolla johtamista kehittämällä

Rekola, Hanna; Surakka, Anne; Saijonkari, Maija; Mäki-Opas, Tomi; Lakka, Timo; Paronen, Elsa. 2023. . . Itä-Suomen yliopisto

Prevalence and associated factors of metabolic-associated fatty liver disease in overweight Finnish children and adolescents

Riekki, Hanna; Aitokari, Linnea; Kivela, Laura; Lahti, Siiri; Hiltunen, Pauliina; Vuorela, Nina; Huhtala, Heini; Lakka, Timo A.; Kurppa, Kalle. 2023. Frontiers in endocrinology. 14:

Promotive and preventive interventions for mental health and well-being in adult populations: a systematic umbrella review

Saijonkari, Maija; Paronen, Elsa; Lakka, Timo; Tolmunen, Tommi; Linnosmaa, Ismo; Lammintakanen, Johanna; Isotalo, Jenni; Rekola, Hanna; Mäki-Opas, Tomi. 2023. Frontiers in public health. 11: . 1201552

A participatory arts programme – Shared experience for family caregivers and care recipients

Vaajoki, Anne; Turjamaa, Riitta; Lakka, Timo; Mäkinen, Eeva; Välimäki, Tarja. 2022. Nursing open. 2023; 10: 3011-3017

A quantitative ultra-performance liquid chromatography high-resolution mass spectrometry analysis of steroids from human scalp hair

Koskivuori, Johanna; Voutilainen, Raimo; Uusitalo, Lauri; Lehtonen, Marko; Lakka, Timo; Auriola, Seppo; Häkkinen, Merja R. 2022. Journal of pharmaceutical and biomedical analysis. 215:

ACE2 expression in adipose tissue is associated with cardio-metabolic risk factors and cell type composition—implications for COVID-19

El-Sayed Moustafa, Julia S.; Jackson, Anne U.; Brotman, Sarah M.; Guan, Li; Villicaña, Sergio; Roberts, Amy L.; Zito, Antonino; Bonnycastle, Lori; Erdos, Michael R.; Narisu, Narisu; Stringham, Heather M.; Welch, Ryan; Yan, Tingfen; Lakka, Timo; Parker, Stephen; Tuomilehto, Jaakko; Seow, Jeffrey; Graham, Carl; Huettner, Isabella; Acors, Sam; Kouphou, Neophytos; Wadge, Samuel; Duncan, Emma L.; Steves, Claire J.; Doores, Katie J.; Malim, Michael H.; Collins, Francis S.; Pajukanta, Päivi; Boehnke, M. 2022. International journal of obesity. 46: 1478-1486

Associations between weight loss history and factors related to type 2 diabetes risk in the Stop Diabetes study

Halali, F; Lapveteläinen, A; Aittola, K; Männikkö, R; Tilles-Tirkkonen, T; Järvelä-Reijonen, E; Absetz, P; Kolehmainen, M; Schwab, U; Lindström, J; Lakka, TA; Pihlajamäki, J; Karhunen, L. 2022. International journal of obesity. 46: 935-942

Associations of diet quality, food consumption, eating frequency, and eating behaviour with dental caries experience in Finnish children: A 2-year longitudinal study

Virkkala, Veera; Eloranta, Aino-Maija; Suominen, Anna Liisa; Vierola, Anu; Ikävalko, Tiina; Väistö, Juuso; Mikkonen, Santtu; Methuen, Mirja; Schwab, Ursula; Viljakainen, Heli; Leinonen, Jukka; Närhi, Matti; Lakka, Timo A.. 2022. British journal of nutrition. [Published 08 August 2022]: 1-11

Cross-sectional associations between cardiorespiratory fitness and NMR-derived metabolic biomarkers in children – the PANIC study

Haapala, Eero A.; Leppänen, Marja H.; Lehti, Maarit; Lintu, Niina; Tompuri, Tuomo; Viitasalo, Anna; Schwab, Ursula; Lakka, Timo A.. 2022. Frontiers in endocrinology. 13: . 954418

Determinants of Cognitive Performance in Children and Adolescents : A Populational Longitudinal Study

Lima, Rodrigo Antunes; Soares, Fernanda Cunha; van Poppel, Mireille; Savinainen, Saija; Mäntyselkä, Aino; Haapala, Eero A; Lakka, Timo. 2022. International journal of environmental research and public health. 19: . 8955

Digitally Supported Lifestyle Intervention to Prevent Type 2 Diabetes Through Healthy Habits: Secondary Analysis of Long-Term User Engagement Trajectories in a Randomized Controlled Trial

Lavikainen, Piia; Mattila, Elina; Absetz, Pilvikki; Harjumaa, Marja; Lindström, Jaana; Järvelä-Reijonen, Elina; Aittola, Kirsikka; Männikkö, Reija; Tilles-Tirkkonen, Tanja; Lintu, Niina; Lakka, Timo; van Gils, Mark; Pihlajamäki, Jussi; Martikainen, Janne. 2022. Journal of medical internet research. 24:

Is low cardiorespiratory fitness a feature of metabolic syndrome in children and adults?

Haapala, Eero A.; Tompuri, Tuomo; Lintu, Niina; Viitasalo, Anna; Savonen, Kai; Lakka, Timo A.; Laukkanen, Jari A.. 2022. Journal of science and medicine in sport. 25: 923-929

Lapsuuden suun terveydenhuollon käynnit ja vanhempien sosioekonominen asema

Tolonen, Ville; Ikävalko, Tiina; Suominen, Liisa; Lakka, Timo; Karvinen, Henri; Törmälehto, Soili; Raittio, Eero. 2022. Suomen hammaslääkärilehti. 29: 44-50

LongITools: Dynamic longitudinal exposome trajectories in cardiovascular and metabolic noncommunicable diseases

Ronkainen, Justiina; Nedelec, Rozenn; Atehortua, Angelica; Balkhiyarova, Zhanna; Cascarano, Anna; Ngoc Dang, Vien; Elhakeem, Ahmed; van Enckevort, Esther; Goncalves Soares, Ana; Haakma, Sido; Halonen, Miia; Heil, Katharina F.; Heiskala, Anni; Hyde, Eleanor; Jacquemin, Bénédicte; Keikkala, Elina; Kerckhoffs, Jules; Klåvus, Anton; Kopinska, Joanna A.; Lepeule, Johanna; Marazzi, Francesca; Motoc, Irina; Näätänen, Mari; Ribbenstedt, Anton; Rundblad, Amanda; Savolainen, Otto; Simonetti, Valentina; de. 2022. Environmental epidemiology. 6:

Mielenterveys- ja päihdeongelmat työelämän ulkopuolella olevilla pohjoissavolaisilla

Kurkinen, Karoliina; Karjalainen, Panu; Rekola, Hanna; Pietikäinen, Liisa; Laakso, Seija; Laine, Katja; Surakka, Anne; Saijonkari, Maija; Lakka, Timo; Mäki-Opas, Tomi; Tolmunen, Tommi. 2022. University of Eastern Finland

Physical activity volume and intensity distribution in relation to bone, lean and fat mass in children

Skinner, Annie M.; Vlachopoulos, Dimitris; Barker, Alan R.; Moore, Sarah A.; Rowlands, Alex V.; Soininen, Sonja; Haapala, Eero A.; Väistö, Juuso; Westgate, Kate; Brage, Soren; Lakka, Timo A.. 2022. Scandinavian journal of medicine and science in sports. 2023; 33: 267-282

Prevalence of erosive tooth wear and associated dietary factors among a group of Finnish adolescents

Methuen, Mirja; Kangasmaa, Hanna; Alaraudanjoki, Viivi Karoliina; Suominen, Anna L.; Anttonen, Vuokko; Vähänikkilä, Hannu; Karjalainen, Panu; Väistö, Juuso; Lakka, Timo A.; Laitala, Marja-Liisa. 2022. Caries research. 56: 477-487

Real-world effectiveness of digital and group-based lifestyle interventions as compared with usual care to reduce type 2 diabetes risk – A stop diabetes pragmatic randomised trial

Lakka, Timo A.; Aittola, Kirsikka; Järvelä-Reijonen, Elina; Tilles-Tirkkonen, Tanja; Männikkö, Reija; Lintu, Niina; Karhunen, Leila; Kolehmainen, Marjukka; Harjumaa, Marja; Mattila, Elina; Järvenpää, Riia; Ermes, Miikka; Mikkonen, Santtu; Martikainen, Janne; Poutanen, Kaisa; Schwab, Ursula; Absetz, Pilvikki; Lindström, Jaana; Pihlajamäki, Jussi. 2022. The Lancet regional health – Europe. 2023; 24:

Sources of vitamin D and determinants of serum 25-hydroxyvitamin D in Finnish adolescents

Soininen, Sonja; Eloranta, Aino-Maija; Schwab, Ursula; Lakka, Timo A. 2022. European journal of nutrition. 2023; 62: 1011-1025

The Composition and Functional Capacities of Saliva Microbiota Differ Between Children With Low and High Sweet Treat Consumption

Lommi, Sohvi; Manzoor, Muhammed; Engberg, Elina; Agrawal, Nitin; Lakka, Timo A.; Leinonen, Jukka; Kolho, Kaija-Leena; Viljakainen, Heli. 2022. Frontiers in nutrition. 9: . 864687

The Mediating Role of Endocrine Factors in the Positive Relationship Between Fat Mass and Bone Mineral Content in Children Aged 9–11 Years: The Physical Activity and Nutrition in Children Study

Constable, Annie M.; Vlachopoulos, Dimitris; Barker, Alan R.; Moore, Sarah A.; Soininen, Sonja; Haapala, Eero A.; Väistö, Juuso; Jääskeläinen, Jarmo; Voutilainen, Raimo; Auriola, Seppo; Häkkinen, Merja R.; Laitinen, Tomi; Lakka, Timo A.. 2022. Frontiers in endocrinology. 13: . 850448

The effects of an 8-year individualised lifestyle intervention on food consumption and nutrient intake from childhood to adolescence: the PANIC Study

Sallinen, Taisa; Viitasalo, Anna; Lintu, Niina; Väistö, Juuso; Soininen, Sonja; Jalkanen, Henna; Haapala, Eero A.; Mikkonen, Santtu; Schwab, Ursula; Lakka, Timo A.; Eloranta, Aino-Maija. 2022. Journal of nutritional science. 11:

Työelämän ulkopuolella olevien positiivista mielenterveyttä tulee parantaa edistämällä terveellisiä elintapoja ja tarjoamalla matalan kynnyksen palveluita

Rekola, Hanna; Kurkinen, Karoliina; Tolmunen, Tommi; Saijonkari, Maija; Surakka, Anne; Pentikäinen, Heikki; Lakka, Timo A; Paronen, Elsa; Mäki-Opas, Tomi. 2022. University of Eastern Finland

Associations of physical activity, sedentary time, and diet quality with biomarkers of inflammation in children

Haapala, Eero A; Väistö, Juuso; Ihalainen, Johanna K; Tomaselli González, Claudia; Leppänen, Marja H; Veijalainen, Aapo; Sallinen, Taisa; Eloranta, Aino-Maija; Ekelund, Ulf; Schwab, Ursula; Brage, Soren; Atalay, Mustafa; Lakka, Timo A. 2021. European journal of sport science. [Epub ahead of print 14 March 2021]: 1-10

Comparison of Communication Channels for Large-Scale Type 2 Diabetes Risk Screening and Intervention Recruitment: Empirical Study

Jalkanen, Kari; Järvenpää, Riia; Tilles-Tirkkonen, Tanja; Martikainen, Janne; Aarnio, Emma; Männikkö, Reija; Rantala, Eeva; Karhunen, Leila; Kolehmainen, Marjukka; Harjumaa, Marja; Poutanen, Kaisa; Ermes, Miikka; Absetz, Pilvikki; Schwab, Ursula; Lakka, Timo; Pihlajamäki, Jussi; Lindström, Jaana; The StopDia Study Group. 2021. JMIR diabetes. 6: e21356

Cost-effectiveness of physical activity intervention in children - results based on the Physical Activity and Nutrition in Children (PANIC) study

Kuvaja-Köllner, Virpi; Lintu, Niina; Lindi, Virpi; Rissanen, Elisa; Eloranta, Aino-Maija; Kiiskinen, Sanna; Martikainen, Janne; Kankaanpää, Eila; Valtonen, Hannu; Lakka, Timo A.. 2021. International journal of behavioral nutrition and physical activity. 18: 116

Dental caries among Finnish teenagers participating in physical activity and diet intervention: association with anthropometrics and behavioural factors

Methuen, Mirja; Kauppinen, Sofia; Suominen, Anna Liisa; Eloranta, Aino-Maija; Väistö, Juuso; Lakka, Timo; Vähänikkilä, Hannu; Anttonen, Vuokko. 2021. Bmc oral health. 21: 333

Enhanced Eating Competence Is Associated with Improved Diet Quality and Cardiometabolic Profile in Finnish Adults with Increased Risk of Type 2 Diabetes

Aittola, Kirsikka; Karhunen, Leila; Männikkö, Reija; Järvelä-Reijonen, Elina; Mikkonen, Santtu; Absetz, Pilvikki; Kolehmainen, Marjukka; Schwab, Ursula; Harjumaa, Marja; Lindström, Jaana; Lakka, Timo; Tilles-Tirkkonen, Tanja; Pihlajamäki, Jussi. 2021. Nutrients. 13: 4030

Exercise, diet, and cognition in a 4-year randomized controlled trial: Dose-Responses to Exercise Training (DR's EXTRA)

Komulainen, Pirjo; Tuomilehto, Jaakko; Savonen, Kai; Männikkö, Reija; Hassinen, Maija; Lakka, Timo A; Hänninen, Tuomo; Kiviniemi, Vesa; Jacobs, David R; Kivipelto, Miia; Rauramaa, Rainer. 2021. American journal of clinical nutrition. 113: 1428-1439

Hyvällä mielellä Pohjois-Savo -hankkeen esiselvitys: Toimenpide-ehdotus ja vaikuttavuuden arviointisuunnitelma

Saijonkari, Maija; Paronen, Elsa; Lakka, Timo; Tolmunen, Tommi; Linnosmaa, Ismo; Lammintakanen, Johanna; Mäki-Opas, Tomi. 2021. Publications of the University of Eastern Finland. General series. .

Liikunnallisuus ja hyvä kunto ehkäisevät tyypin 2 diabetesta ja valtimotautien riskitekijöitä lapsuudesta lähtien

Väistö, Juuso; Haapala, Eero; Lakka, Timo A. 2021. Liikunta ja tiede. 58: 62-64

Longitudinal and cross-sectional associations of adherence to 24-hour movement guidelines with cardiometabolic risk

Leppänen, Marja H; Haapala, Eero A; Väistö, Juuso; Ekelund, Ulf; Brage, Søren; Kilpeläinen, Tuomas O; Lakka, Timo A. 2021. Scandinavian journal of medicine and science in sports. 2022; 32: 255-266

Longitudinal associations of physical activity, sedentary time, and cardiorespiratory fitness with arterial health in children - the PANIC study

Korhonen, Marika; Väisto, Juuso; Veijalainen, Aapo; Leppänen, Marja; Ekelund, Ulf; Laukkanen, Jari A; Brage, Soren; Lintu, Niina; Haapala, Eero A; Lakka, Timo A. 2021. Journal of sports sciences. 39: 1980-1987

Multi-ancestry genome-wide association study accounting for gene-psychosocial factor interactions identifies novel loci for blood pressure traits

Sun, Daokun; Richard, Melissa A.; Musani, Solomon K.; Sung, Yun Ju; Winkler, Thomas W.; Schwander, Karen; Chai, Jin Fang; Guo, Xiuqing; Kilpeläinen, Tuomas O.; Vojinovic, Dina; Aschard, Hugues; Bartz, Traci M.; Bielak, Lawrence F.; Brown, Michael R.; Chitrala, Kumaraswamy; Hartwig, Fernando P.; Horimoto, Andrea R.V.R.; Liu, Yongmei; Manning, Alisa K.; Noordam, Raymond et al. [incl. Heikkinen, Sami; Lakka, Timo]. 2021. HGG advances. 2: 100013

Oxygen-18 and Carbon-13 isotopes in eCO 2 and erythrocytes carbonic anhydrase activity of Finnish prediabetic population

Kårlund, Anna; Kääriäinen, Teemu; Kostamo, Vili M; Kokkola, Tarja; Kolehmainen, Marjukka; Lakka, Timo A; Pihlajamäki, Jussi; Manninen, Albert. 2021. Journal of breath research. 15: 21001

Plasma irisin and its associations with oxidative stress in athletes suffering from overtraining syndrome

Joro, R; Korkmaz, A; Lakka, TA; Uusitalo, ALT; Atalay, M. 2021. Physiology international. 10: 513-526

Response

Haapala, Eero A; Barker, Alan R; Lakka, Timo A. 2021. Medicine and science in sports and exercise. 53: 454

Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability

Mägi, Reedik; Hottenga, Jouke- Jan; Grallert, Harald; Perry, John R. B.; Bouatia-Naji, Nabila; Marullo, Letizia; Rybin, Denis; Jansen, Rick; Min, Josine L.; Dimas, Antigone S.; Ulrich, Anna; Zudina, Liudmila; Gådin, Jesper R.; Jiang, Longda; Faggian, Alessia; Bonnefond, Amélie; Fadista, Joao; Stathopoulou, Maria G.; Isaacs, Aaron; Willems, Sara M et al. [incl. Kuusisto, Johanna; Laakso, Markku; Lakka, Timo, Uusitupa, Matti]. 2021. Nature communications. 12: 24

The Positive Relationship between Moderate-to-Vigorous Physical Activity and Bone Mineral Content Is Not Mediated by Free Leptin Index in Prepubertal Children: The PANIC Study

Constable, Annie M.; Porter, Josie E.; Benger, Danielle; Vlachopoulos, Dimitris; Barker, Alan R.; Moore, Sarah A.; Soininen, Sonja; Haapala, Eero A.; Westgate, Kate; Brage, Soren; Agostinete, Ricardo R.; Fernandes, Romulo A.; Lakka, Timo A.. 2021. International journal of environmental research and public health. 18: 5365

The independent and interactive associations of physical activity intensity and vitamin D status with bone mineral density in prepubertal children: the PANIC Study

Constable, AM; Vlachopoulos, D; Barker, AR; Moore, SA; Soininen, S; Haapala, EA; Väistö, J; Westgate, K; Brage, S; Mähönen, A; Lakka, TA. 2021. Osteoporosis international. 32: 1609-1620

The trans-ancestral genomic architecture of glycemic traits

Chen, J; Spracklen, CN; Marenne, G; Varshney, A; Corbin, LJ; Luan, J; Willems, SM; Wu, Y; Zhang, X; Horikoshi, M; Boutin, TS; Mägi, R; Waage, J; Li-Gao, R; Chan, KHK; Yao, J; Anasanti, MD; Chu, AY; Claringbould, A; Heikkinen, J; et al. [incl. Kuulasmaa, T; Kuusisto, J; Laakso, M; Lakka, T; Uusitupa, M; Vangipurapu, J]. 2021. Nature genetics. 53: 840-860

A 2 year physical activity and dietary intervention attenuates the increase in insulin resistance in a general population of children: the PANIC study

Lakka, Timo A; Lintu, Niina; Väistö, Juuso; Viitasalo, Anna; Sallinen, Taisa; Haapala, Eero A; Tompuri, Tuomo T; Soininen, Sonja; Karjalainen, Panu; Schnurr, Theresia M; Mikkonen, Santtu; Atalay, Mustafa; Kilpeläinen, Tuomas O; Laitinen, Tomi; Laaksonen, David E; Savonen, Kai; Brage, Soren; Schwab, Ursula; Jääskeläinen, Jarmo; Lindi, Virpi; Eloranta, Aino-Maija. 2020. Diabetologia. 63: 2270-2281

An overview on the associations between health behaviors and brain health in children and adolescents with special reference to diet quality

Naveed, Sehrish; Lakka, Timo; Haapala, Eero A. 2020. International journal of environmental research and public health. 17: 953

Associations between cardiorespiratory fitness, motor competence, and adiposity in children

Haapala, Eero A; Gao, Ying; Lintu, Niina; Väistö, Juuso; Vanhala, Anssi; Tompuri, Tuomo; Lakka, Timo A; Finni, Taija. 2020. Translational sports medicine. 2021; 4: 56-64

Associations of dietary carbohydrate and fatty acid intakes with cognition among children

Naveed, Sehrish; Venäläinen, Taisa; Eloranta, Aino-Maija; Erkkilä, Arja; Jalkanen, Henna; Lindi, Virpi; Lakka, Timo; Haapala, Eero. 2020. Public health nutrition. 23: 1657-1663

Child-related and Parental Predictors for Thelarche in a General Population of Girls: The PANIC Study

Savinainen, SE; Viitasalo, A; Sallinen, TM; Jääskeläinen, JES; Lakka, TA. 2020. Pediatric research. 88: 676-680

Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

Surendran, Praveen; Feofanova, Elena V; Lahrouchi, Najim; Ntalla, Ioanna; Karthikeyan, Savita; Cook, James; Chen, Lingyan; Mifsud, Borbala; Yao, Chen; Kraja, Aldi T; Cartwright, James H; Hellwege, Jacklyn N; Giri, Ayush; Tragante, Vinicius; Thorleifsson, Gudmar; Liu, Dajiang J; Prins, Bram P; Stewart, Isobel D; Cabrera, Claudia P; Eales, James M; et al. (incl. Stanakova, Alena; Laatikainen, Tiina; Laakso, Markku; Lakka, Timo A). 2020. Nature genetics. 52: 1314-1332

Effects of a 2-Year Lifestyle Intervention on Cardiorespiratory Fitness in 6-8- Year-Old Children: The PANIC Study

Agbaje, AO; Barker, AR; Eloranta, A-M; Haapala, EA; Lintu, N; Savonen, K; Kilpeläinen, TO; Brage, S; Lakka, TA. 2020. Pediatric exercise science

Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci

de Las Fuentes, Lisa; Sung, Yun Ju; Noordam, Raymond; Winkler, Thomas; Feitosa, Mary F; Schwander, Karen; Bentley, Amy R; Brown, Michael R; Guo, Xiuqing; Manning, Alisa; Chasman, Daniel I; Aschard, Hugues; Bartz, Traci M; Bielak, Lawrence F; Campbell, Archie; Cheng, Ching-Yu; Dorajoo, Rajkumar; Hartwig, Fernando P; Horimoto, A R V R; Li, Changwei et al [incl. Heikkinen, Sami; Lakka, Timo]. 2020. Molecular psychiatry. 2021; 26: 2111-2125

Leisure-time cross-country skiing and the risk of venous thromboembolism: A prospective cohort study

Kunutsor, Setor; Lakka, Timo; Kurl, Sudhir; Mäkikallio, Timo; Jae, Sae Young; Laukkanen, Jari. 2020. European journal of preventive cardiology. 2021; 28: 1138-1141

Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits

Vogelezang, Suzanne; Bradfield, Jonathan P; Ahluwalia, Tarunveer S; Curtin, John A; Lakka, Timo A; Grarup, Niels; Scholz, Markus; van der Most, Peter J; Monnereau, Claire; Stergiakouli, Evie; Heiskala, Anni; Horikoshi, Momoko; Fedko, Iryna O; Vilor-Tejedor, Natalia; Cousminer, Diana L; Standl, Marie; Wang, Carol A; Viikari, Jorma; Geller, Frank; Íñiguez, Carmen; et al. (Incl. Atalay, Mustafa; Lindi, Virpi). 2020. PLoS genetics. 16: e1008718

Primary hand motor representation areas in healthy children, preadolescents, adolescents, and adults

Säisänen, Laura; Könönen, Mervi; Niskanen, Eini; Lakka, Timo; Lintu, Niina; Vanninen, Ritva; Julkunen, Petro; Määttä, Sara. 2020. Neuroimage. 2021; 228: 117702

StopDia-hankkeesta vinkkejä terveyden edistämiseen ja hyte-johtamiseen

Tilles-Tirkkonen, Tanja; Männikkö, Reija; Lindström, Jaana; Harjumaa, Marja; Aittola, Kirsikka; Järvelä-Reijonen, Elina; Rantala, Eeva; Martikainen, Janne; Lakka, Timo; Pihlajamäki, Jussi. 2020. Ravitsemusasiantuntija. 6: 4-7

Suomalaisten lasten ja nuorten ruokaympäristö ja toimenpide-ehdotukset sen kehittämiseen terveyttä edistäväksi

Rantala, Eeva; Martikainen, Janne; Lakka, Timo; Vanhatalo, Saara; Heiskanen, Jari; Väistö, Juuso; Leväsluoto, Johanna; Hassinen, Maija; Eloranta, Aino-Maija; Sigfrids, Anton; Harjumaa, Marja. 2020. Valtioneuvoston selvitys- ja tutkimustoiminnan julkaisusarja. .

The effects of a 2-year physical activity and dietary intervention on plasma lipid concentrations in children: the PANIC Study

Eloranta, Aino-Maija; Sallinen, Taisa; Viitasalo, Anna; Lintu, Niina; Väistö, Juuso; Jalkanen, Henna; Tompuri, Tuomo T; Soininen, Sonja; Haapala, Eero A; Kiiskinen, Sanna; Schnurr, Theresia M; Kilpeläinen, Tuomas O; Mikkonen, Santtu; Savonen, Kai; Atalay, Mustafa; Brage, Soren; Laaksonen, David E; Lindi, Virpi; Ågren, Jyrki; Schwab, Ursula; et al. [incl. Jääskeläinen, Jarmo; Lakka, Timo]. 2020. European journal of nutrition. 2021; 60: 425-434

A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure

Sung, Yun Ju; de Las Fuentes, Lisa; Winkler, Thomas W; Chasman, Daniel I; Bentley, Amy R; Kraja, Aldi T; Ntalla, Ioanna; Warren, Helen R; Guo, Xiuqing; Schwander, Karen; Manning, Alisa K; Brown, Michael R; Aschard, Hugues; Feitosa, Mary F; Franceschini, Nora; Lu, Yingchang; et al. (incl. Heikkinen, Sami; Kuusisto, Johanna; Laakso, Markku; Stancáková, Alena; Lakka, Timo A). 2019. Human molecular genetics. 28: 2615-2633

A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity

Bradfield, Jonathan P; Vogelezang, Suzanne; Felix, Janine F; Chesi, Alessandra; Helgeland, Øyvind; Horikoshi, Momoko; Karhunen, Ville; Lowry, Estelle; Cousminer, Diana L; Ahluwalia, Tarunveer S; Thiering, Elisabeth; Boh, Eileen Tai-Hui; Zafarmand, Mohammad H; Vilor-Tejedor, Natalia; Wang, Carol A; Joro, Raimo; Chen, Zhanghua; Gauderman, William J; Pitkänen, Niina; Parra, Esteban J; et al. (incl. Atalay, Mustafa; Lakka, Timo A; Lindi, Virpi). 2019. Human molecular genetics. 28: 3327-3338

Abdominal adiposity and cardiometabolic risk factors in children and adolescents: a Mendelian randomization analysis

Viitasalo, A; Schnurr, TM; Pitkänen, N; Hollensted, M; Nielsen, TRH; Pahkala, K; Atalay, M; Lind, MV; Heikkinen, S; Frithioff-Bøjsøe, C; Fonvig, CE; Grarup, N; Kähönen, M; Carrasquilla, GD; Larnkjaer, A; Pedersen, O; Michaelsen, KF; Lakka, TA; Holm, JC; Lehtimäki, T; et al.. 2019. American journal of clinical nutrition. 110: 1079-1087

Adiposity Criteria in Assessing Increased Cardiometabolic Risk in Prepubertal Children

Tompuri, Tuomo Tapani; Jaaskelainen, Jarmo; Lindi, Virpi; Laaksonen, David Elliot; Eloranta, Aino-Maija; Viitasalo, Anna; Laitinen, Tomi; Lakka, Limo Antero. 2019. Frontiers in endocrinology. 10: 410

Associations of Cardiorespiratory Fitness and Adiposity With Arterial Stiffness and Arterial Dilatation Capacity in Response to a Bout of Exercise in Children

Agbaje, Andrew O; Haapala, Eero A; Lintu, Niina; Viitasalo, Anna; Vaisto, Juuso; Khan, Sohaib; Veijalainen, Aapo; Tompuri, Tuomo; Laitinen, Tomi; Lakka, Timo A. 2019. Pediatric exercise science. 31: 238-247

Associations of IGF-1 and Adrenal Androgens with Cognition in Childhood

Mäntyselkä, A; Haapala, EA; Lindi, V; Häkkinen, MR; Auriola, S; Jääskeläinen, J; Lakka, TA. 2019. Hormone research in paediatrics. 91: 329-335

Associations of cardiometabolic risk factors with heart rate variability in 6-8-year-old children: the PANIC Study

Leppänen, MH; Haapala, EA; Veijalainen, A; Seppälä, S; Oliveira, RS; Lintu, N; Laitinen, T; Tarvainen, MP; Lakka, TA. 2019. Pediatric diabetes. 2020; 21: 251-258

Associations of physical activity, sedentary time, and cardiorespiratory fitness with heart rate variability in 6- to 9-year-old children: the PANIC study

Veijalainen, A; Haapala, EA; Väistö, J; Leppänen, MH; Lintu, N; Tompuri, T; Seppälä, S; Ekelund, U; Tarvainen, MP; Westgate, K; Brage, S; Lakka, TA. 2019. European journal of applied physiology. 119: 2487-2498

Cardiorespiratory Fitness, Physical Activity, and Insulin Resistance in Children

Haapala, EA; Wiklund, P; Lintu, N; Tompuri, T; Väistö, J; Finni, T; Tarkka, IM; Kemppainen. T; Barker, AR; Ekelund, U; Brage, S; Lakka, TA. 2019. Medicine and science in sports and exercise. 2020; 52: 1144-1152

Cross-country skiing and the risk of acute myocardial infarction: A prospective cohort study

Laukkanen, JA; Lakka, TA; Ogunjesa, BA; Kurl, S; Kunutsor, SK. 2019. European journal of preventive cardiology. [First Published August 19, 2019]: 1-4

Digitally supported program for type 2 diabetes risk identification and risk reduction in real-world setting: protocol for the StopDia model and randomized controlled trial

Pihlajamäki, J; Männikkö, R; Tilles-Tirkkonen, T; Karhunen, L; Kolehmainen, M; Schwab, U; Lintu, N; Paananen, J; Järvenpää, R; Harjumaa, M; Martikainen, J; Kohl, J; Poutanen, K; Ermes, M; Absetz, P; Lindström, J; Lakka, TA. 2019. Bmc public health. 19: 255

Eating Competence Is Associated with Lower Prevalence of Obesity and Better Insulin Sensitivity in Finnish Adults with Increased Risk for Type 2 Diabetes: The StopDia Study

Tilles-Tirkkonen, Tanja; Aittola, Kirsikka; Männikkö, Reija; Absetz, Pilvikki; Kolehmainen, Marjukka; Schwab, Ursula; Lindström, Jaana; Lakka, Timo; Pihlajamäki, Jussi; Karhunen, Leila. 2019. Nutrients. 2020; 12: 104

Functional and structural asymmetry in primary motor cortex in Asperger syndrome: a navigated TMS and imaging study

Säisänen, L; Määttä, S; Julkunen, P; Niskanen, E; Kallioniemi, E; Gröhn, H; Kemppainen, S; Lakka, TA; Lintu, N; Eloranta, AM; Vanninen, R; Makkonen, I; Könönen, M. 2019. Brain topography. 32: 504-518

Fyysinen aktiivisuus ja ravitsemus lasten terveyden edistämisessä - tavoitteena lihavuuden, tyypin 2 diabeteksen ja valtimotautien ehkäisy

Lakka, Timo A; Talvia, Sanna; Sääkslahti, Arja; Haapala, Eero. Teoksessa: Pietilä, Anna-Maija; Terkamo-Moisio, Anja(toim.) , 2019. Näkökulmia terveyteen ja sen edistämiseen. s. 133-166. Itä-Suomen yliopisto

GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI

Alves, AC; De Silva, NMG; Karhunen, V; Sovio, U; Das, S; Rob Taal, H; Warrington, NM; Lewin, AM; Kaakinen, M; Cousminer, DL; Thiering, E; Timpson, NJ; Bond, TA; Lowry, E; Brown, CD; Estivill, X; Lindi, V; Bradfield, JP; Geller, F; Speed, D; et al. for BIOS Consortium [incl. Lakka, TA]. 2019. Science advances. 5: eaaw3095

Genetic predisposition to higher body fat yet lower cardiometabolic risk in children and adolescents

Viitasalo, Anna; Schnurr, Theresia M.; Pitkanen, Niina; Hollensted, Mette; Nielsen, Tenna R. H.; Pahkala, Katja; Lintu, Niina; Lind, Mads V.; Atalay, Mustafa; Frithioff-Bojsoe, Christine; Fonvig, Cilius E.; Grarup, Niels; Kahonen, Mika; Larnkjaer, Anni; Pedersen, Oluf; Holm, Jens-Christian; Michaelsen, Kim F.; Lakka, Timo A.; Lehtimaki, Terho; Raitakari, Olli; et al.. 2019. International journal of obesity. 43: 2007-2016

Hyvinvoinnin ja osallisuuden edistäminen vaatii uusia vaikuttavia keinoja

Mäki-Opas, Tomi; Tilles-Tirkkonen, Tanja; Saari, Eveliina; Järvenpää, Riia; Lindström, Jaan; Karhunen, Leila; Kurki, Marjo; Pihlajamäki, Jussi; Niemi, Anna-Maija; Laaksonen, Linda Maria; Korkiakangas, Eveliina; Lakka, Timo; Vaarama, Marja; Laitinen, Jaana. 2019. Policy Brief / SA. : 1-12

Integrative analysis of gene expression, DNA methylation, physiological traits, and genetic variation in human skeletal muscle

Taylor, DL; Jackson, AU; Narisu, N; Hemani, G; Erdos, MR; Chines, PS; Swift, A; Idol, J; Didion, JP; Welch, RP; Kinnunen, L; Saramies, J; Lakka, TA; Laakso, M; Tuomilehto, J; Parker, SCJ; Koistinen, HA; Davey Smith, G; Boehnke, M; Scott, LJ; et al.. 2019. Proceedings of the National Academy of Sciences of the United States of America. 116: 10883-10888

Longitudinal Associations of Fitness, Motor Competence, and Adiposity with Cognition

Haapala, Eero A; Lintu, Niina; Väistö, Juuso; Tompuri, Tuomo; Soininen, Sonja; Viitasalo, Anna; Eloranta, Aino-Maija; Venäläinen, Taisa; Sääkslahti, Arja; Laitinen, Tomi; Lakka, Timo A. 2019. Medicine and science in sports and exercise. 51: 465-471

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

Warrington, NM; Beaumont, RN; Horikoshi, M; Day, FR; Helgeland, Ø; Laurin, C; Bacelis, J; Peng, S; Hao, K; Feenstra, B; Wood, AR; Mahajan, A; Tyrrell, J; Robertson, NR; Rayner, NW et al. (ncl. Joro, R; Atalay, M; Eloranta, AM; Lakka, TA). 2019. Nature genetics. 51: 804-814

Maturation changes the excitability and effective connectivity of the frontal lobe: A developmental TMS-EEG study

Määttä, S; Säisänen, L; Kallioniemi, E; Lakka, TA; Lintu, N; Haapala, EA; Koskenkorva, P; Niskanen, E; Ferreri, F; Könönen, M. 2019. Human brain mapping. 40: 2320-2335

Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions

de Vries, PS; Brown, MR; Bentley, AR; Sung, YJ; Winkler, TW; Ntalla, I; Schwander, K; Kraja, AT; Guo, X; Franceschini, N; Cheng, CY; Sim, X; Vojinovic, D; Huffman, JE; Musani, SK; Li, C; Feitosa, MF; Richard, MA; Noordam, R; Aschard, H; et al. (Incl. Kuusisto, Johanna; Laakso, Markku; Lakka, Timo; Heikkinen, Sami). 2019. American journal of epidemiology. 188: 1033-1054

Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

Bentley, AR; Sung, YJ; Brown, MR; Winkler, TW; Kraja, AT; Ntalla, I; Schwander, K; Chasman, DI; Lim, E; Deng, X; Guo, X; Liu, J; Lu, Y; Cheng, CY; Sim, X; Vojinovic, D; Lakka, TA; Heikkinen, S; Kuusisto, J; Laakso, M; et al. (incl. Laakso, Markku; Heikkinen, Sami; Kuusisto, Johanna; Lakka, Timo; Rauramaa, Rainer). 2019. Nature genetics. 51: 636-648

Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

Kilpeläinen, TO; Bentley, AR; Noordam, R; Sung, YJ; Schwander, K; Winkler, TW; Jakupovic, H; Chasman, DI; Manning, A; Ntalla, I; Aschard, H; Brown, MR; de Las Fuentes, L; Franceschini, N; Guo, X; Vojinovic, D; Aslibekyan, S; Feitosa, MF; Kho, M; Musani, SK; et al. [Incl. Lakka, Timo; Heikkinen, Sami; Kuusisto, Johanna; Laakso, Markku]. 2019. Nature communications. 10: 376

Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

Justice, AE; Karaderi, T; Highland, HM; Young, KL; Graff, M; Lu, Y; Turcot, V; Auer, PL; Fine, RS; Guo, X; Schurmann, C; Lempradl, A; Marouli, E; Mahajan, A; Winkler, TW; Locke, AE; Medina-Gomez, C; Esko, T; Vedantam, S; Giri, A; Lo, KS; et al. (Incl. Kuusisto, Johanna; Laakso, Markku; Lakko, Timo; Uusitupa, Matti; Vanhala, Mauno). 2019. Nature genetics. 51: 452-469

The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects

Middeldorp, Christel M; Felix, Janine F; Mahajan, Anubha; EArly Genetics Lifecourse Epidemiology (EAGLE) consortium; Early Growth Genetics (EGG) consortium (Incl Atalay, Mustafa; Lakka, Timo A); McCarthy, Mark I. 2019. European journal of epidemiology. 34: 279-300

Analysis by LC-MS/MS of endogenous steroids from human serum, plasma, endometrium and endometriotic tissue

Häkkinen, MR; Heinosalo, T; Saarinen, N; Linnanen, T; Voutilainen, R; Lakka, T; Jääskeläinen, J; Poutanen, M; Auriola, S. 2018. Journal of pharmaceutical and biomedical analysis. 152: 165-172

Associations of Dehydroepiandrosterone Sulfate with Cardiometabolic Risk Factors in Prepubertal Children

Mäntyselkä, A; Lindi, V; Viitasalo, A; Eloranta, AM; Ågren, J; Väisänen, S; Voutilainen, R; Laitinen, T; Lakka, TA; Jääskeläinen, J. 2018. Journal of clinical endocrinology and metabolism. 103: 2592-2600

Associations of Genetic Susceptibility to Alzheimer's Disease with Adiposity and Cardiometabolic Risk Factors among Children in a 2-Year Follow-up Study

Haapala, Eero A; Paananen, Jussi; Hiltunen, Mikko; Lakka, Timo A. 2018. Journal of Alzheimer's disease. 64: 587-595

Associations of cardiorespiratory fitness and adiposity with arterial stiffness and arterial dilation capacity in response to exercise in children

Agbaje, AO; Haapala, EA; Lintu, N; Viitasalo, A; Väistö, J; Khan, S; Veijalainen, A; Tompuri, T; Laitinen, T; Lakka, TA. 2018. Pediatric exercise science

Birth weight is associated with dietary factors at the age of 6-8 years: the Physical Activity and Nutrition in Children (PANIC) study

Eloranta, AM; Jääskeläinen, J; Venäläinen, T; Jalkanen, H; Kiiskinen, S; Mäntyselkä, A; Schwab, U; Lindi, V; Lakka, TA. 2018. Public health nutrition. 21: 1278-1285

Body fat mass, lean body mass and associated biomarkers as determinants of bone mineral density in children 6-8 years of age - The Physical Activity and Nutrition in Children (PANIC) study

Soininen, Sonja; Sidoroff, Virpi; Lindi, Virpi; Mahonen, Anitta; Kröger, Liisa; Kröger, Heikki; Jääskeläinen, Jarmo; Atalay, Mustafa; Laaksonen, David E; Laitinen, Tomi; Lakka, Timo A. 2018. Bone. 108: 106-114

Consortium-based genome-wide meta-analysis for childhood dental caries traits

Haworth, S; Shungin, D; van der Tas, JT; Vucic, S; Medina-Gomez, C; Yakimov, V; Feenstra, B; Shaffer, JR; Lee, MK; Standl, M; Thiering, E; Wang, C; Bønnelykke, K; Waage, J; Eyrich Jessen, L; Nørrisgaard, PE; Joro, R; Seppälä, I; Raitakari, O; Dudding, T; et al. [Incl Lakka, T; Eloranta, A-M; Vierola, A]. 2018. Human molecular genetics. 27: 3113-3127

Development of corticospinal motor excitability and cortical silent period from mid-childhood to adulthood - a navigated TMS study

Säisänen, Laura; Julkunen, Petro; Lakka, Timo; Lindi, Virpi; Könönen, Mervi; Määttä; Sara. 2018. Neurophysiologie clinique-clinical neurophysiology. 48: 65-75

Health-related correlates of psychological well-being among girls and boys 6-8 years of age: The Physical Activity and Nutrition in Children study

Ikävalko, T; Lehto, S; Lintu, N; Väistö, J; Eloranta, AM; Haapala, EA; Vierola, A; Myllykangas, R; Tuomilehto, H; Brage, S; Pahkala, R; Närhi, M; Lakka, TA. 2018. Journal of paediatrics and child health. 54: 506-509

Interactions between genetic variation and cellular environment in skeletal muscle gene expression

Taylor, DL; Knowles, DA; Scott, LJ; Ramirez, AH; Casale, FP; Wolford, BN; Guan, L; Varshney, A; Albanus, RD; Parker, SC; Narisu, N; Chines, PS; Erdos, MR; Welch, RP; Kinnunen, L; Saramies, J; Sundvall, J; Lakka, TA; Laakso, M; Tuomilehto, J; et al.. 2018. PLoS ONE. 13: e0195788

Kasvu, sukupuolinen kypsyminen ja kehitys sekä niiden merkitys liikuntatieteissä

Savinainen, Saija; Lakka, Timo A; Vlachopoulos, Dimitris; Sääkslahti, Arja; Helajärvi, Harri; Ihalainen, Johanna K; Finni, Taija; Haapala, Eero A. 2018. Liikunta ja tiede. 55: 23-29

Lasten ja nuorten kestävyyskunto

Lintu, Niina; Joensuu, Laura; Barker, Alan; Sansum, Kate; Lakka, Timo A; Huotari, Pertti; Haapala, Eero A. 2018. Liikunta ja tiede. 55: 36-43

Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects

Medina-Gomez, C; Kemp, JP; Trajanoska, K; Luan, J; Chesi, A; Ahluwalia, TS; Mook-Kanamori, DO; Ham, A; Hartwig, FP; Evans, DS; Joro, R; Nedeljkovic, I; Zheng, HF; Zhu, K; Atalay, M; Liu, CT; Nethander, M; Broer, L; Porleifsson, G; Mullin, BH et al. [incl. Lakka, T]. 2018. American journal of human genetics. 102: 88-102

Longitudinal associations of physical activity and sedentary time with cardiometabolic risk factors in children

Väistö, Juuso; Haapala, Eero A; Viitasalo, Anna; Schnurr, Theresia M; Kilpeläinen, Tuomas O; Karjalainen, Panu; Westgate, Kate; Lakka, Hanna-Maaria; Laaksonen, David E; Ekelund, Ulf; Brage, Søren; Lakka, Timo A. 2018. Scandinavian journal of medicine and science in sports. 2019; 29: 113-123

Mediating effects of motor performance, cardiorespiratory fitness, physical activity, and sedentary behaviour on the associations of adiposity and other cardiometabolic risk factors with academic achievement in children

Haapala, Eero A; Lintu, Niina; Eloranta, Aino-Maija; Venäläinen, Taisa; Poikkeus, Anna-Maija; Ahonen, Timo; Lindi, Virpi; Lakka, Timo A. 2018. Journal of sports sciences. 36: 2296-2303

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries

Feitosa, MF; Kraja, AT; Chasman, DI; Sung, YJ; Winkler, TW; Ntalla, I; Guo, X; Franceschini, N; Cheng, CY; Sim, X; Vojinovic, D; Marten, J; Musani, SK; Li, C; Bentley, AR; Brown, MR; Schwander, K; Richard, MA; Noordam, R; Aschard, H; et al. (incl. Laakso, Markku; Heikkinen, Sami; Kuusisto, Johanna; Lakka, Timo; Yaluri, Alena). 2018. PLoS ONE. 13: e0198166

Peak oxygen uptake cut-points to identify children at increased cardiometabolic risk - The PANIC Study

Agbaje, Andrewe O; Haapala, Eero A; Lintu, Nina; Viitasalo, Anna; Barker, Alan R; Takken, Tim; Tompuri, Tuomo; Lindi, Virpi; Lakka, Timo A. 2018. Scandinavian journal of medicine and science in sports. 2019; 29: 16-24

Serum 25-Hydroxyvitamin D, Plasma Lipids, and Associated Gene Variants in Prepubertal Children

Soininen, Sonja; Eloranta, Aino-Maija; Viitasalo, Anna; Dion, Geneviève; Erkkilä, Arja; Sidoroff, Virpi; Lindi, Virpi; Mahonen, Anitta; Lakka, Timo A. 2018. Journal of clinical endocrinology and metabolism. 103: 2670-2679

Simultaneous analysis by LC-MS/MS of 22 ketosteroids with hydroxylamine derivatization and underivatized estradiol from human plasma, serum and prostate tissue

Häkkinen, Merja R; Murtola, Teemu; Voutilainen, Raimo; Poutanen, Matti; Linnanen, Tero; Koskivuori, Johanna; Lakka, Timo; Jääskeläinen, Jarmo; Auriola, Seppo. 2018. Journal of pharmaceutical and biomedical analysis. 2019; 164: 642-652

Uric acid level as a risk factor for cardiovascular and all-cause mortality in middle-aged men. A prospective cohort study (in Russian)

Niskanen, LK; Laaksonen, DE; Nyyssonen, K; Alfthan, G; Lakka, H-M; Lakka, TA; Salonen, J. 2018. Kardiologiâ v Belarusi. 10: 440-445

A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk

Manning A, Highland HM, Gasser J, Sim X, Tukiainen T, Fontanillas P, Grarup N, Rivas MA, Mahajan A, Locke AE, Cingolani P, Pers TH, Viñuela A, Brown AA, Wu Y, Flannick J, Fuchsberger C, Gamazon ER, Gaulton KJ, Im HK et al. (incl. Lakka Timo, Kuulasmaa Teemu, Laakso Markku, Uusitupa Matti). 2017. Diabetes. 66: 2019-2032

Associations of Objectively Measured Physical Activity and Sedentary Time With Arterial Stiffness in Pre-pubertal Children

Haapala Eero, Väistö Juuso, Veijalainen Aapo, Lintu Niina, Wiklund P,etri Westgate Kate, Ekelund Ulf, Lindi Virpi, Brage Soren, Lakka Timo A. 2017. Pediatric exercise science. 29: 326-335

Associations of lifestyle factors with serum dehydroepiandrosterone sulfate and insulin-like growth factor-1 concentration in prepubertal children

Mäntyselkä A, Jääskeläinen J, Eloranta AM, Väistö J, Voutilainen R, Ong K, Brage S, Lakka TA, Lindi V. 2017. Clinical endocrinology. 2018; 88: 234-242

Determinants for craniofacial pains in children 6-8 years of age: the PANIC study

Vierola A, Suominen AL, Eloranta AM, Lintu N, Ikävalko T, Närhi M, Lakka T. 2017. Acta odontologica scandinavica. 75: 453-460

Development of cortical motor circuits between childhood and adulthood: A navigated TMS-HdEEG study

Määttä S, Könönen M, Kallioniemi E, Lakka T, Lintu N, Lindi V, Ferreri F, Ponzo D, Säisänen L. 2017. Human brain mapping. 38: 2599-2615

Eating behaviour is associated with eating frequency and food consumption in 6-8 year-old children: The Physical Activity and Nutrition in Children (PANIC) study

Jalkanen H, Lindi V, Schwab U, Kiiskinen S, Venäläinen T, Karhunen L, Lakka TA, Eloranta AM. 2017. Appetite. 114: 28-37

Exome-wide association study of plasma lipids in >300,000 individuals

Liu DJ, Peloso GM, Yu H, Butterworth AS, Wang X, Mahajan A, Saleheen D, Emdin C, Alam D, Alves AC, Amouyel P, Di Angelantonio E, Arveiler D, Assimes TL, Auer PL, Baber U, Ballantyne CM, Bang LE, Benn M, Bis JC et al.. 2017. Nature genetics. 49: 1758-1766

Genetic predisposition to adiposity is associated with increased objectively assessed sedentary time in young children

Schnurr TM, Viitasalo A, Eloranta AM, Damsgaard CT, Mahendran Y, Have CT, Väistö J, Hjorth MF, Christensen LB, Brage S, Atalay M, Lyytikäinen LP, Lindi V, Lakka T, Michaelsen KF, Kilpeläinen TO, Hansen T. 2017. International journal of obesity. 42: 111-114

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

Justice Anne E, Winkler Thomas W, Feitosa Mary F, Graff Misa, Fisher Virginia A, Young Kristin, Barata Llilda, Deng Xuan, Czajkowski Jacek, Hadley David, Ngwa Julius S, Ahluwalia Tarunveer S, Chu Audrey Y, Heard-Costa Nancy L, Lim Elise, Perez Jeremiah, Eicher John D, Kutalik Zoltan, Xue Luting, Mahajan Anubha et al.. 2017. Nature communications. 8: 14977

Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults

Graff M, Scott RA, Justice AE, Young KL, Feitosa MF, Barata L, Winkler TW, Chu AY, Mahajan A, Hadley D, Xue L, Workalemahu T, Heard-Costa NL, den Hoed M, Ahluwalia TS, Qi Q, Ngwa JS, Renström F, Quaye L, Eicher JD et al.. 2017. PLoS genetics. 13: e1006528

High Leisure-Time Physical Activity Is Associated With Reduced Risk of Sudden Cardiac Death Among Men With Low Cardiorespiratory Fitness

Hagnäs, MJ; Lakka, TA; Mäkikallio, TH; Kurl, S; Savonen, K; Rauramaa, R; Laukkanen, JA. 2017. Canadian journal of cardiology. 2018; 34: 288-294

Is there a duty to participate in a health research? A viewpoint of children 6-8 years of age and their parents

Länsimies H, Halkoaho A, Pietilä A-M, Lintu N, Kangasniemi M, Eloranta A-M, Viitasalo A, Lakka TA. 2017. International diabetes nursing. 13: 49-54

Maternal and fetal genetic contribution to gestational weight gain

Warrington NM, Richmond R, Fenstra B, Myhre R, Gaillard R, Paternoster L, Wang CA, Beaumont RN, Das S, Murcia M, Barton SJ, Espinosa A, Thiering E, Atalay M, Pitkänen N, Ntalla I, Jonsson AE, Freathy R, Karhunen V, Tiesler CMT et al. for the Early Growth Genetics (EGG) consortium. 2017. International journal of obesity. 42: 775-784

New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals

Kraja Aldi T, Cook James P, Warren Helen R, Surendran Praveen, Liu Chunyu, Evangelou Evangelos, Mannig Alisa K, Grarup Niels, Drenos Fotios, Sim Xueling, Smith Albert Vernon, Amin Najaf, Blakemore Alexandra I F, Bork-Jensen Jette, Brandslund Ivan, Farmaki Aliki-Eleni, Fava Cristiano, Ferreira Teresa, Herzig Karl-Heinz, Giri Ayush et al.. 2017. Circulation: cardiovascular genetics. 10: e001778

Physical activity, sedentary behaviour, and socioeconomic status among Finnish girls and boys aged 6 - 8 years

Lampinen Eeva-Kaarina, Eloranta Aino-Maija, Haapala Eero A, Lindi Virpi, Väistö Juuso, Lintu Niina, Karjalainen Panu, Kukkonen-Harjula Katriina, Laaksonen David, Lakka Timo A. 2017. European journal of sport science. 17: 462-472

Predictors of sleep disordered breathing in children: the PANIC study

Ikävalko, T; Närhi, M; Eloranta, AM; Lintu, N; Myllykangas, R; Vierola, A; Tuomilehto, H; Lakka, T; Pahkala, R. 2017. European journal of orthodontics. 2018; 40: 268-272

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T, Giri A, Graff M, Guo X, Hendricks AE, Karaderi T, Lempradl A, Locke AE, Mahajan A, Marouli E, Sivapalaratnam S, Young KL, Alfred T et al. (incl. Laakso Markku, Lakka Timo, Uusitupa Matti). 2017. Nature genetics. 50; 2018: 26-41

Rare and low-frequency coding variants alter human adult height

Marouli Eirini, Graff Mariaelisa, Medina-Gomez Carolina, Sin Lo Ken, Wood Andrew R, Kjaer Troels R, Fine Rebecca S, Lu Yingchang, Schurmann Claudia, Highland Heather M, Rüeger Sina, Thorleifsson Gudmar, Justice Anne E, Lamparter David, Stirrups Kathleen E, Turcot Valérie, Young Kristin L, Winkler Thomas W, Esko Tõnu, Karaderi Tugce et al. (incl Kuusisto Johanna, Laakso Markku, Lakka Timo A). 2017. Nature. 542: 186-190

Relation of oxygen uptake to work rate in prepubertal healthy children - reference for VO2/W-slope and effect on cardiorespiratory fitness assessment

Tompuri, Tuomo; Lintu, Niina; Laitinen, Tomi; Lakka, Timo A. 2017. Clinical physiology and functional imaging. 2018; 38: 645-651

Vähäinen fyysinen aktiivisuus ja runsas fyysinen passiivisuus ovat yhteydessä 6-8-vuotiaiden lasten ylipainoon

Haapala Eero A, Väistö Juuso, Lintu Niina, Eloranta Aino-Maija, Lindi Virpi, Lakka Timo A. 2017. Liikunta ja tiede. 54: 106-112

A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape

Ried JS, Jeff M J, Chu AY, Bragg-Gresham JL, van Dongen J, Huffman JE, Ahluwalia TS, Cadby G, Eklund N, Eriksson J, Esko T, Feitosa MF, Goel A, Gorski M, Hayward C, Heard-Costa NL, Jackson AU, Jokinen E, Kanoni S, Kristiansson K et al. 2016. Nature communications. 7: 13357

Adiposity, physical activity and neuromuscular performance in children

Haapala Eero A, Vaisto, Juuso, Lintu Niina, Tompuri Tuomo, Brage Soren, Westgate Kate, Ekelund Ulf, Lampinen Eeva-Kaarina, Saakslahti Arja, Lindi Virpi, Lakka Timo A. 2016. Journal of sports sciences. 34: 1699-706

Association of MBOAT7 gene variant with plasma ALT levels in children: The PANIC study

Viitasalo A, Eloranta A-M, Atalay M, Romeo S, Pihlajamäki J, Lakka TA. 2016. Pediatric research. 80: 651-655

Associations of Sedentary Behavior, Physical Activity, Cardiorespiratory Fitness, and Body Fat Content With Pain Conditions in Children: The Physical Activity and Nutrition in Children Study

Vierola Anu, Suominen Anna Liisa, Lindi Virpi, Viitasalo Anna, Ikävalko Tiina, Lintu Niina, Väistö Juuso, Kellokoski Jari, Närhi Matti, Lakka Timo A. 2016. Journal of pain. 17: 845-853

Associations of TM6SF2 167K allele with liver enzymes and lipid profile in children: the PANIC Study

Viitasalo Anna, Pihlajamäki Jussi, Paananen Jussi, Atalay Mustafa, Lindi Virpi, Lakka Timo A. 2016. Pediatric research. 79: 684-688

Cardiorespiratory fitness and exercise-induced ST segment depression in assessing the risk of sudden cardiac death in men

Hagnäs MJ, Lakka TA, Kurl S, Rauramaa R, Mäkikallio TH, Savonen K, Laukkanen JA. 2016. Heart. 103: 383-389

Comparison between parameters from maximal cycle ergometer test first without respiratory gas analysis and thereafter with respiratory gas analysis among healthy prepubertal children

Tompuri Tuomo T, Lintu Niina, Soininen Sonja, Laitinen Tomi, Lakka Timo A. 2016. Applied physiology nutrition and metabolism-physiologie appliquee nutrition et metabolisme. 41: 624-630

Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

Winkler Thomas W, Justice Anne E, Graff Mariaelisa, Barata Llilda, Feitosa Mary F, Chu Su, Czajkowski Jacek, Esko Tõnu, Fall Tove, Kilpeläinen Tuomas O, Lu Yingchang, Mägi Reedik, Mihailov Evelin, Pers Tune H, Rüeger Sina, Teumer Alexander, Ehret Georg B, Ferreira Teresa, Heard-Costa Nancy L, Karjalainen Juha et al. 2016. PLoS genetics. 12: e1006166

Cross-sectional associations of objectively-measured physical activity and sedentary time with body composition and cardiorespiratory fitness in mid-childhood: the PANIC study

Collings Paul J, Westgate Kate, Väistö Juuso, Wijndaele Katrien, Atkin Andrew J, Haapala Eero A, Lintu Niina, Laitinen Tomi, Ekelund Ulf, Brage Soren, Lakka Timo A. 2016. Sports medicine. [Epub ahead of print 24 Aug 2016]: 1-12

Determinants of cardiorespiratory fitness in a population sample of girls and boys aged 6-8 years

Lintu Niina, Savonen Kai, Viitasalo Anna, Tompuri Timo, Paananen Jussi, Tarvainen Mika P, Lakka Timo. 2016. Journal of physical activity and health. [epub ahead of print]: 1-22

Determinants of serum 25-hydroxyvitamin D concentration in Finnish children: the Physical Activity and Nutrition in Children (PANIC) study

Soininen Sonja, Eloranta Aino-Maija, Lindi Virpi, Venäläinen Taisa, Zaproudina Nina, Mahonen Anitta, Lakka Timo A. 2016. British journal of nutrition. 115: 1080-1091

Diet quality and academic achievement: a prospective study among primary school children

Haapala Eero A, Eloranta Aino-Maija, Venäläinen Taisa, Jalkanen Henna, Poikkeus Anna-Maija, Ahonen Timo, Lindi Virpi, Lakka Timo A. 2016. European journal of nutrition. 56: 2299-2308

Dietary quality indices in relation to cardiometabolic risk among Finnish children aged 6-8 years - The PANIC study

Eloranta Aino-Maija, Schwab Ursula, Venäläinen Taisa, Kiiskinen Sanna, Lakka HM, Laaksonen David E, Lakka Timo A, Lindi Virpi. 2016. Nutrition metabolism and cardiovascular diseases. 26: 833-841

Effect of a 2-y dietary and physical activity intervention on plasma fatty acid composition and estimated desaturase and elongase activities in children: the Physical Activity and Nutrition in Children Study

Venäläinen Taisa M, Viitasalo Anna M, Schwab Ursula S, Eloranta Aino-Maija, Haapala Eero A, Jalkanen Henna P, de Mello Vanessa DF, Laaksonen David E, Lindi Virpi I, Ågren Jyrki J, Lakka Timo A. 2016. American journal of clinical nutrition. 104: 964-972

Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index

Hinney A, Kesselmeier M, Jall S, Volckmar AL, Föcker M, Antel J, Heid IM, Winkler TW, Grant SF, Guo Y, Bergen AW, Kaye W, Berrettini W, Hakonarson H, Herpertz-Dahlmann B, de Zwaan M, Herzog W, Ehrlich S, Zipfel S, Egberts KM et al., GCAN, WTCCC3, EGG, GIANT, Price Foundation Collaborative Group, Children's Hospital of Philadelphia/Price Foundation. 2016. Molecular psychiatry. 2017; 22: 192-201

Food sources of energy and nutrients in Finnish girls and boys 6-8 years of age - the PANIC study

Eloranta Aino-Maija, Venäläinen Taisa, Soininen Sonja, Jalkanen Henna, Kiiskinen Sanna, Schwab Ursula, Lakka Timo A, Lindi Virpi. 2016. Food and nutrition research. 60: 32444

Genome-wide associations for birth weight and correlations with adult disease

Horikoshi M, Beaumont RN, Day FR, Warrington NM, Kooijman MN, Fernandez-Tajes J, Feenstra B, van Zuydam NR, Gaulton KJ, Grarup N, Bradfield JP, Strachan DP, Li-Gao R, Ahluwalia TS, Kreiner E, Rueedi R, Lyytikäinen LP, Cousminer DL, Wu Y, Thiering E et al.. 2016. Nature. [Epub ahead of print 28 Sep 2016]: 1-20

Physical activity and sedentary time in relation to academicachievement in children

Haapala EA, Väistö J, Lintu N, Westgate K, Ekelund U, Poikkeus A-M, Brage S, Lakka TA. 2016. Journal of science and medicine in sport. 2017; 20: 583-589

Plasma polyunsaturated fatty acids are directly associated with cognition in overweight children but not in normal weight children

Haapala EA, Viitasalo A, Venäläinen T, Eloranta AM, Ågren J, Lindi V, Lakka TA. 2016. Acta paediatrica. 105: 1502-1507

Prevalence and associated factors of abnormal liver values in children with celiac disease

Aarela Linnea, Nurminen Samuli, Kivela Laura, Huhtala Heini, Maki Markku, Viitasalo Anna, Kaukinen Katri, Lakka Timo, Kurppa Kalle. 2016. Digestive and liver disease. 48: 1023-1029

Response: food fortification as a means to increase vitamin D intake

Soininen Sonja, Eloranta Aino-Maija, Lindi Virpi, Lakka Timo A. 2016. British journal of nutrition. 116: 1134-1135

The Effects of a 2-year Individualized and Family-based Lifestyle Intervention on Physical Activity, Sedentary Behavior and Diet in Children

Viitasalo Anna, Eloranta Aino-Maija, Lintu Niina, Väistö Juuso, Venäläinen Taisa, Kiiskinen Sanna, Karjalainen Panu, Peltola Jaana, Lampinen Eeva-Kaarina, Haapala Eero A, Paananen Jussi, Schwab Ursula, Lindi Virpi, Lakka Timo A. 2016. Preventive medicine. 87: 81-88

The genetic regulatory signature of type 2 diabetes in human skeletal muscle

Scott Laura J, Erdos Michael R, Huyghe Jeroen R, Welch Ryan P, Beck Andrew T, Wolford Brooke N, Chines Peter S, Didion John P, Narisu Narisu, Stringham Heather N, Taylor D Leeland, Jackson Anne U, Vadlamudi Swarooparani, Bonnycastle Bonny M, Kinnunen Leena, Saramies Jouko, Sundvall Jouko, D'Oliveira Albanus Ricardo, Kiseleva Anna, Hensley John et al (inc. LakkaTimo A, Laakso Markku). 2016. Nature communications. 7: 11764

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

Ehret GB, Ferreira T, Chasman DI, Jackson AU, Schmidt EM, Johnson T, Thorleifsson G, Luan J, Donnelly LA, Kanoni S, Petersen AK, Pihur V, Strawbridge RJ, Shungin D, Hughes MF, Meirelles O, Kaakinen M, Bouatia-Naji N, Kristiansson K, Shah S et al.. 2016. Nature genetics. 48: 1171-1184

Tieteelliset perusteet varhaisvuosien fyysisen aktiivisuuden suosituksille

Sääkslahti Arja, Muuronen Kaisu, Haapala Eero, Pulakka Anna, Haapala Henna, Lakka Timo A, Laukkanen Arto, Määttä Suvi, Reunamo Jyrki, Roos Eva, Soini Anne, Mäki Päivi, Iivonen Susanna, Asunta Piritta, Viholainen Helena, Ahonen Timo, Rintala Pauli, Cantell Marja, Kyhälä Anna-Liisa. 2016. Opetus- ja kulttuuriministeriön julkaisuja. .

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

Surendran P, Drenos F, Young R, Warren H, Cook JP, Manning AK, Grarup N, Sim X, Barnes DR, Witkowska K, Staley JR, Tragante V, Tukiainen T, Yaghootkar H, Masca N, Freitag DF, Ferreira T, Giannakopoulou O, Tinker A, Harakalova M et al. 2016. Nature genetics. 48: 1151-1161

Association of plasma fatty acid composition with plasma irisin levels in normal weight and overweight/obese children

Viitasalo A, Ågren J, Venäläinen T, Pihlajamäki J, Jääskeläinen J, Korkmaz A, Atalay M, Lakka TA. 2015. Pediatric obesity. 2015; 11: 299-305

Associations of Physical Performance and Adiposity with Cognition in Children

Haapala Eero A, Lintu Niina, Väistö Juuso, Robinson Leah E, Viitasalo Anna, Lindi Virpi, Lakka Timo A. 2015. Medicine and science in sports and exercise. 47: 2166-2174

Associations of cardiorespiratory fitness, physical activity, and adiposity with arterial stiffness in children

Veijalainen A, Tompuri T, Haapala EA, Viitasalo , Lintu N, Väistö J, Laitinen T, Lindi V, Lakka TA. 2015. Scandinavian journal of medicine and science in sports. [epub ahead of print 29 Jul 2015]: -

Associations of diet quality with cognition in children - the Physical Activity and Nutrition in Children Study

Haapala Eero A, Eloranta Aino-Maija, Venäläinen Taiisa, Schwab Ursula, Lindi Virpi, Lakka Timo A. 2015. British journal of nutrition. 114: 1080-1087

Biological interpretation of genome-wide association studies using predicted gene functions

Pers Tune H, Karjalainen Juha M, Chan Yingleong, Westra Harm-Jan, Wood Andrew R, Yang Jian, Lui Julian C, Vedantam Sailaja, Gustafsson Stefan, Esko Tonu, Frayling Tim, Speliotes Elizabeth K, Genetic Investigation of ANthropometric Traits (GIANT) Consortium (incl. Johanna Kuusisto, Markku Laakso, Timo Lakka, Matti Uusitupa), Boehnke Michael, Raychaudhuri Soumya, Fehrmann Rudolf SN, Hirschhorn Joel N, Franke Lude. 2015. Nature communications. 6: 5890

Cardiopulmonary fitness is a function of lean mass, not total body weight: The DR's EXTRA study

Krachler Benno, Savonen Kai, Komulainen Pirjo, Hassinen Maija, Lakka Timo A., Rauramaa Rainer. 2015. European journal of preventive cardiology. 22: 1171-1179

Cross-sectional associations of plasma fatty acid composition and estimated desaturase and elongase activities with cardiometabolic risk in Finnish children - The PANIC study

Venäläinen Taisa, Ågren Jyrki, Schwab Ursula, de Mello Vanessa D, Eloranta Aino-Maija, Laaksonen David E, Lindi Virpi, Lakka Timo A. 2015. Journal of clinical lipidology. 2016; 10: 82-91

Dietary Intake, FTO Genetic Variants, and Adiposity: A Combined Analysis of Over 16,000 Children and Adolescents

Qi Qibin, Downer Mary K, Kilpeläinen Tuomas O, Taal H Rob, Barton Sheila J, Ntalla Ioanna, Standl Marie, Boraska Vesna, Huikari Ville, Kiefte-de Jong Jessica C, Körner Antje, Lakka Timo A, Liu Gaifen, Magnusson Jessica, Okuda Masayuki, Raitakari Olli, Richmond Rebecca, Scott Robert A, Bailey Mark ES, Scheuermann Kathrin et al. 2015. Diabetes. 64: 2467-2476

Finger skin temperatures in 8- to 11-year-old children: determinants including physical characteristics and seasonal variation. The Physical Activity an Nutrition in Children (PANIC) Study

Zaproudina Nina, Närhi Matti, Veijalainen Aapo, Laitinen Tomi, Lakka Timo A. 2015. European journal of applied physiology. [epub ahead of print 26 Nov 2015]: 1-9

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

Gaulton KJ, Ferreira T, Lee Y, Raimondo A, Mägi R, Reschen ME, Mahajan A, Locke A, William Rayner N, Robertson N, Scott RA, Prokopenko I, Scott LJ, Green T, Sparso T, Thuillier D, Yengo L, Grallert H, Wahl S, Frånberg M et al.. 2015. Nature genetics. 47: 1415-1425

Genetic studies of body mass index yield new insights for obesity biology

Locke Adam E, Kahali Bratati, Berndt Sonja I, Justice Anne E, Pers Tune H, Day Felix R, Powell Corey, Vedantam Sailaja, Buchkovich Martin L, Yang Jian, Croteau-Chonka Damien C, Esko Tonu, Fall Tove, Ferreira Teresa, Gustafsson Stefan, Kutalik Zoltán, Luan Jian'an, Mägi Reedik, Randall Joshua C, Winkler Thomas W et al. 2015. Nature. 518: 197-206

Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index

Felix Janine F, Bradfield Jonathan P, Monnereau Claire, van der Valk Ralf JP, Stergiakouli Evie, Chesi Alessandra, Gaillard Romy, Feenstra Bjarke, Thiering Elisabeth, Kreiner-Møller Eskil, Mahajan Anubha, Pitkänen Niina, Joro Raimo, Cavadino Alana, Huikari Ville, Franks Steve, Groen-Blokhuis Maria M, Cousminer Diana L, Marsh Julie A, Lehtimäki Terho et al.; Early Growth Genetics (EGG) Consortium; Bone Mineral Density in Childhood Study BMDCS Consortium. 2015. Human molecular genetics. (2016) 25: 389-403

Lateral facial profile may reveal the risk for sleep disordered breathing in children - The PANIC-study

Ikävalko Tiina, Närhi Matti, Lakka Timo, Myllykangas Riitta, Tuomilehto Henri, Vierola Anu, Pahkala Riitta. 2015. Acta odontologica scandinavica. online April 20, 2015: 6 p

Motor cortical alterations in children with Asperger's syndrome studied with navigated TMS

Säisänen Laura, Könönen Mervi, Anttonen Meri, Niskanen Eini, Lintu Niina, Lindi Virpi, Lakka Timo, Vanninen Ritva, Makkonen Ismo, Julkunen Petro, Määttä Sara. 2015.

New genetic loci link adipose and insulin biology to body fat distribution

Shungin Dmitry, Winkler Thomas W, Croteau-Chonka Damien C, Ferreira Teresa, Locke Adam E, Mägi Reedik, Strawbridge Rona J, Pers Tune H, Fischer Krista, Justice Anne E, Workalemahu Tsegaselassie, Wu Joseph MW, Buchkovich Martin L, Heard-Costa Nancy L, Roman Tamara S, Drong Alexander W, Song Ci, Gustafsson Stefan, Day Felix R, Esko Tonu et al. 2015. Nature. 518: 187-196

Obesity is an important source of bias in the assessment of cardiorespiratory fitness

Krachler Benno, Savonen Kai, Lakka Timo. 2015. American heart journal. 170: e7-e8

Secular trends affect timing of emergence of permanent teeth

Eskeli Ritva, Lösönen Matias, Ikävalko Tiina, Myllykangas Riitta, Lakka Timo, Laine-Alava Maija T. 2015. Angle orthodontist. Published Online: April 29, 2015: 6 p

The 148 M allele of the PNPLA3 is associated with plasma irisin levels in a population sample of Caucasian children: The PANIC Study

Viitasalo Anna, Mustafa Atalay, Pihlajamäki Jussi, Jääskeläinen Jarmo, Korkmaz Ayhan, Kaminska Dorota, Lindi Virpi, Lakka Timo A.. 2015. Metabolism: clinical and experimental. 64: 793-796

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

Winkler Thomas W, Justice Anne E, Graff Mariaelisa, Barata Llilda, Feitosa Mary F, Chu Su, Czajkowski Jacek, Esko Tõnu, Fall Tove, Kilpeläinen Tuomas O, Lu Yingchang, Mägi Reedik, Mihailov Evelin, Pers Tune H, Rüeger Sina, Teumer Alexander, Ehret Georg B, Ferreira Teresa, Heard-Costa Nancy L, Karjalainen Juha et al. 2015. PLoS genetics. 11: e1005378

The value of cardiorespiratory fitness and exercise-induced ST segment depression in predicting death from coronary heart disease

Hagnas Magnus J., Kurl Sudhir, Rauramaa Rainer, Lakka Timo A., Makikallio Timo H., Savonen Kai, Laukkanen Jari A.. 2015. International journal of cardiology. 196: 31-33

VO2max/kg is expected to be lower in obese individuals!

Krachler Benno, Savonen Kai, Komulainen Pirjo, Hassinen Maija, Lakka Timo A, Rauramaa Rainer. 2015. International journal of cardiology. 189: 234

A Central Role for GRB10 in Regulation of Islet Function in Man

Prokopenko Inga, Poon Wenny, Mägi Reedik, Prasad BR, Salehi S Albert, Almgren Peter, Osmark Peter, Bouatia-Naji Nabila, Wierup Nils, Fall Tove, Stancáková Alena, Barker Adam, Lagou Vasiliki, Osmond Clive, Xie Weijia, Lahti Jari, Jackson Anne U, Cheng Yu-Ching, Liu Jie, O'Connell Jeffrey R et al. (including Kuusisto Johanna, Laakso Markku, Lakka Timo). 2014. PLoS genetics. 10: e1004235

A novel common variant in DCST2 is associated with length in early life and height in adulthood

van der Valk Ralf JP, Kreiner-Moller Eskil, Kooijman Marjolein N, Guxens Mònica, Stergiakouli Evangelia, Sääf Annika, Bradfield Jonatan P, Geller Frank, Geoffrey Hayes M, Cousminer Diana L, Körner Antje, Thiering Elisabeth, Curtin John A, Myhre Ronny, Huikari Ville, Joro Raimo, Kerkhof Marjan, Warrington Nicole M, Pitkänen Niina, Ntalla Ioanna et. al.. 2014. Human molecular genetics. Epub ahead of print: -

Associations Of Cardiovascular Fitness, Motor Performance And Adiposity With Cognition In Children

Haapala Eero A, Tompuri Tuomo, Lintu Niina, Laitinen Tomi, Lindi Virpi, Lakka Timo A. 2014. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE. SUPPLEMENT

Associations of I148M variant in PNPLA3 gene with plasma ALT levels during 2-year follow-up in normal weight and overweight children: the PANIC Study

Viitasalo A, Pihlajamaki J, Lindi V, Atalay M, Kaminska D, Joro R, Lakka TA. 2014. Pediatric obesity. -:

Cardiorespiratory fitness, respiratory function and hemodynamic responses to maximal cycle ergometer exercise test in girls and boys aged 9-11 years: the PANIC Study

Lintu Niina, Viitasalo Anna, Tompuri Tuomo, Veijalainen Aapo, Hakulinen Mikko, Laitinen Tomi, Savonen Kai, Lakka Timo A. 2014. European journal of applied physiology. Epub ahead of print: -

Correlates of Low Physical Activity Levels in Aging Men and Women: The DR's EXTRA Study

Hakola Leena, Hassinen Maija, Komulainen Pirjo, Lakka Timo A, Savonen Kai, Rauramaa Rainer. 2014. Journal of aging and physical activity. Epub ahead of print: -

Cross-Sectional Associations of Food Consumption with Plasma Fatty Acid Composition and Estimated Desaturase Activities in Finnish Children

Venäläinen Taisa, Schwab Ursula, Ågren Jyrki, de Mello Vanessa, Lindi Virpi, Eloranta Aino-Maija, Kiiskinen Sanna, Laaksonen David, Lakka Timo A. 2014. Lipids. 49: 467-479

Defining the role of common variation in the genomic and biological architecture of adult human height

Wood Andrew R, Esko Tonu, Yang Jian, Vedantam Sailaja, Pers Tune H, Gustafsson Stefan, Chu Audrey Y, Estrada Karol, Luan Jian'an, Kutalik Zoltán, Amin Najaf, Buchkovich Martin L, Croteau-Chonka Damien C, Day Felix R, Duan Yanan, Fall Tove, Fehrmann Rudolf, Ferreira Teresa, Jackson Anne U, Karjalainen Juha et.al.. 2014. Nature genetics. 46: 1173-86

Effects of extended-release niacin with laropiprant in high-risk patients

HPS2-THRIVE Collaborative Group, Landray MJ, Haynes R, Hopewell JC, Parish S, Aung T, Tomson J, Wallendszus K, Craig M, Jiang L, Collins R, Armitage J. 2014. The new england journal of medicine. 371: 203-212

Ennenaikaisen adrenarken sukupuolierot saattavat johtua erilaisesta kehon rasvakoostumuksesta

Mäntyselkä Aino, Jääskeläinen Jarmo, Lindi Virpi, Viitasalo Anna, Tompuri Tuomo, Voutilainen Raimo, Lakka Timo A. 2014. Duodecim. 130: 101

Genome-wide Enrichment Analysis between Endometriosis and Obesity-related Traits Reveals Novel Susceptibility Loci

Rahmioglu Nilufer, Macgregor Stuart, Drong Alexander W, Hedman Åsa K, Harris Holly R, Randall Joshua C, Prokopenko Inga, The International EndoGene Consortium (IEC), The GIANT Consortium, Nyholt Dale R, Morris Andrew P, Montgomery Grant W, Missmer Stacey A, Lindgren Cecilia M, Zondervan Krina T. 2014. Human molecular genetics. Epub ahead of print: -

Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty

Cousminer Diana L, Stergiakouli Evangelia, Berry Diane J, Ang Wei, Groen-Blokhuis Maria M, Körner Antje, Siitonen Niina, Ntalla Ioanna, Marinelli Marcella, Perry John RB, Kettunen Johannes, Jansen Rick, Surakka Ida, Timpson Nicholas J, Ring Susan, Mcmahon George, Power Chris, Wang Carol, Kähönen Mika, Jorma Viikari et. al.. 2014. Human molecular genetics. 23: 4451-64

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.

Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium, Asian Genetic Epidemiology Network Type 2 Diabetes (AGEN-T2D) Consortium, South Asian Type 2 Diabetes (SAT2D) Consortium, Mexican American Type 2 Diabetes (MAT2D) Consortium, Type 2 Diabetes Genetic Exploration by Nex-generation sequencing in multi-Ethnic Samples (T2D-GENES) Consortium, Mahajan A, Go MJ, Zhang W, Below JE, Gaulton KJ, Ferreira T, Horikoshi M, Johnson AD, Ng MC, Prokopenko I, Saleheen D, Wang X, Zeggini E, Abec. 2014. Nature genetics. 46: 234-244

Measures of cardiorespiratory fitness in relation to measures of body size and composition among children

Tompuri Tuomo, Lintu Niina, Savonen Kai, Laitinen Tomi, Laaksonen David, Jääskeläinen Jarmo, Lakka Timo A. 2014. Clinical physiology and functional imaging. Epub ahead of print: -

Moderators of Maintained Increase in Aerobic Exercise Among Aging Men and Women in a 4-year Randomized Controlled Trial: The DR's EXTRA Study

Hakola Leena, Savonen Kai, Komulainen Pirjo, Hassinen Maija, Rauramaa Rainer, Lakka Timo A. 2014. Journal of physical activity and health. -: -

Novel approach identifies SNPs in SLC2A10 and KCNK9 with evidence for parent-of-origin effect on body mass index

Hoggart Clive J, Venturini Giulia, Mangino Massimo, Gomez Felicia, Ascari Giulia, Zhao Jing Hua, Teumer Alexander, Winkler Thomas W, T¨ernikova Natalia, Luan Jian'an, Mihailov Evelin, Ehret Georg B, Zhang Weihua, Lamparter David, Esko Tõnu, Macé Aurelian, Rüeger Sina, Bochud Pierre-Yves, Barcella Matteo, Dauvilliers Yves et al (including Atalay Mustafa, Kuusisto Johanna, Lakka Timo, Yaluri Alena, Laakso Markku, Uusitupa Matti). 2014. PLoS genetics. 10: e1004508

Physical activity and sedentary behaviour in relation to cardiometabolic risk in children: cross-sectional findings from the Physical Activity and Nutrition in Children (PANIC) Study

Väistö J, Eloranta A-M, Viitasalo A, Tompuri T, Lintu N, Karjalainen P, Lampinen E-K, Ågren J, Laaksonen DE, Lakka H-M, Lindi V, Lakka TA. 2014. International journal of behavioral nutrition and physical activity. 11: 55

The presentation of adrenarche is sexually dimorphic and modified by body adiposity

Mäntyselkä Aino, Jääskeläinen Jarmo, Lindi Virpi, Viitasalo Anna, Tompuri Tuomo, Voutilainen Raimo, Lakka Timo A. 2014. Journal of clinical endocrinology and metabolism. 99: 3889-3894

Validation of metabolic syndrome score by confirmatory factor analysis in children and adults and prediction of cardiometabolic outcomes in adults

Viitasalo Anna, Lakka Timo A, Laaksonen David E, Savonen Kai, Lakka Hanna-Maaria, Hassinen Maija, Komulainen Pirjo, Tompuri Tuomo, Kurl Sudhir, Laukkanen Jari A, Rauramaa Rainer. 2014. Diabetologia. Epub ahead of print: -

Assessment of body composition by dual-energy X-ray absorptiometry, bioimpedance analysis and anthropometrics in children: the Physical Activity and Nutrition in Children study

Tompuri TT, Lakka TA, Hakulinen M, Lindi V, Laaksonen DE, Kilpeläinen TO, Jääskeläinen J, Lakka H-M, Laitinen T. 2013. Clinical physiology and functional imaging. 2015; 35: 21-33

Associations of motor and cardiovascular performance with academic skills in children

Haapala EA, Poikkeus A-M, Tompuri T, Kukkonen-Harjula K, Leppänen PHT, Lindi V, Lakka TA. 2013. Medicine and science in sports and exercise. online: x-x

Cardiovascular fitness and haemodynamic responses to maximal cycle ergometer exercise test in children 6-8 years of age

Lintu N, Tompuri T, Viitasalo A, Soininen S, Laitinen T, Savonen K, Lindi V, Lakka TA. 2013. Journal of sports sciences. online: -

Common variants associated with plasma triglycerides and risk for coronary artery disease

Do R, Willer CJ, Schmidt EM, Sengupta S, Gao C, Peloso GM, Gustafsson S, Kanoni S, Ganna A, Chen J, Buchkovich ML, Mora S, Beckmann JS, Bragg-Gresham JL, Chang H-Y, Demirkan A, Den Hertog HM, Donnelly LA, Ehret GB, Esko T et.al.. 2013. Nature genetics. 45: 1345-52

Dietary factors associated with metabolic risk score in Finnish children aged 6-8 years: the PANIC study

Eloranta AM, Lindi V, Schwab U, Kiiskinen S, Venäläinen T, Lakka HM, Laaksonen DE, Lakka TA. 2013. European journal of nutrition. online: -

Discovery and refinement of loci associated with lipid levels

Willer CJ, Schmidt EM, Sengupta S, Peloso GM, Gustafsson S, Kanoni S, Ganna A, Chen J, Buchkovich ML, Mora S, Beckmann JS, Bragg-Gresham JL, Chang H-Y, Demirkan A, Den Hertog HM, Do R, Donnelly LA, Ehret GB, Esko T, Feitosa MF et.al.. 2013. Nature genetics. 45: 1274-1283

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

Berndt SI, Gustafsson S, Mägi R, Ganna A, Wheeler E, Feitosa MF, Justice AE, Monda KL, Croteau-Chonka DC, Day FR, Esko T, Fall T, Ferreira T, Gentilini D, Jackson AU, Luan J, Randall JC, Vedantam S, Willer CJ, Winkler TW, et al. (including Atalay M, Kuusisto J, Lakka TA, Stancakova A, Laakso M, Uusitupa M). 2013. Nature genetics. 45: 501-512

Lapsuusiän liikunnan merkitys - kardiometabolinen näkökulma

Valtonen M, Heinonen Olli J, Lakka Timo A, Tammelin T. 2013. Duodecim. 129: 1153-8

Meta-analysis of gene-level associations for rare variants based on single-variant statistics

Hu Y-J, Berndt SI, Gustafsson S, Ganna A, Genetic Investigation of ANthropometric Traits (GIANT) Consortium (including M Atalay, T Lakka, J Kuusisto, M Laakso), Hirschhorn J, North KE, Ingelsson E, Lin D-Y et.al.. 2013. American journal of human genetics. 93: 236-248

Metabolic risk factors are associated with stiffness index, reflection index and finger skin temperature in children

Veijalainen A, Tompuri T, Laitinen T, Lintu N, Viitasalo A, Laaksonen DE, Jääskeläinen J, Lakka TA. 2013. Circulation journal. 77: 1281-1288

Normal values for heart rate variability parameters in children 6-8 years of age: the PANIC Study

Seppälä S, Laitinen T, Tarvainen MP, Tompuri T, Veijalainen A, Savonen K, Lakka T. 2013. Clinical physiology and functional imaging. Article first published online: -

Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits

Randall JC, Winkler TW, Kutalik Z, Berndt SI, Jackson AU, Monda KL, Kilpeläinen TO, Esko T, Mägi R, Li S, Workalemahu T, Feitosa MF, Croteau-Chonka DC, Day FR, Fall T, Ferreira T, Gustafsson S, Locke AE, Mathieson I, Scherag A, et al. (including J Kuusisto, M Laakso, M Atalay, T Lakka). 2013. PLoS genetics. 9: e1003500

Trans-Ethnic Fine-Mapping of Lipid Loci Identifies Population-Specific Signals and Allelic Heterogeneity That Increases the Trait Variance Explained

Wu Y, Waite LL, Jackson AU, Sheu WH, Buyske S, Absher D, Arnett DK, Boerwinkle E, Bonnycastle LL, Carty CL, Cheng I, Cochran B, Croteau-Chonka DC, Dumitrescu L, Eaton CB, Franceschini N, Guo X, Henderson BE, Hindorff LA, Kim E, et al. (including Stancakova A, Kuusisto J, Laakso M, Uusitupa M, Rauramaa R Lakka T.). 2013. PLoS genetics. 9: e1003379

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

Manning AK, Hivert MF, Scott RA, Grimsby JL, Bouatia-Naji N, Chen H, Rybin D, Liu CT, Bielak LF, Prokopenko I, Amin N, Barnes D, Cadby G, Hottenga JJ, Ingelsson E, Jackson AU, Johnson T, Kanoni S, Ladenvall C, Lagou V et.al.. 2012. Nature genetics. 44: 659-669

A genome-wide association meta-analysis identifies new childhood obesity loci

Bradfield JP, Taal HR, Timpson NJ, Scherag A, Lecoeur C, Warrington NM, Hypponen E, Holst C, Valcarcel B, Thiering E, Salem RM, Schumacher FR, Cousminer DL, Sleiman PMA, Zhao J, Berkowitz RI, Vimaleswaran KS, Jarick I, Pennell CE, Evans DM et.al.. 2012. Nature genetics. 44: 526-531

Clinical signs of temporomandibular disorders and various pain conditions among children 6 to 8 years of age: The Panic Study

Vierola A, Suominen AL, Ikävalko T, Lintu N, Lindi V, Lakka H-M, Kellokoski J, Närhi M, Lakka TA. 2012. Journal of orofacial pain. 26: 17-25

Clustering of Metabolic Risk Factors Is Associated with High-Normal Levels of Liver Enzymes among 6- to 8-Year-Old Children: The PANIC Study

Viitasalo A, Laaksonen DE, Lindi V, Eloranta A-M, Jääskeläinen J, Tompuri T, Väisänen S, Lakka H-M, Lakka TA. 2012. Metabolic syndrome and related disorders. 10: 337-343

Common variants at 12q15 and 12q24 are associated with infant head circumference

Taal HR, St Pourcain B, Thiering E, Das S, Mook-Kanamori DO, Warrington NM, Kaakinen M, Kreiner-Moller E, Bradfield JP, Freathy RM, Geller F, Guxens M, Cousminer DL, Kerkhof M, Timpson NJ, Ikram MA, Beilin LJ, Bonnelykke K, Buxton JL, Charoen P et.al.. 2012. Nature genetics. 44: 532-538

Common variants at 6q22 and 17q21 are associated with intracranial volume

Ikram MA, Fornage M, Smith AV, Seshadri S, Schmidt R, Debette S, Vrooman HA, Sigurdsson S, Ropele S, Taal HR, Kanamori-Mook DO, Coker LH, Longstreth Jr WT, Niessen WJ, DeStefano AL, Beiser A, Zijdenbos AP, Struchalin M, Jack Jr CR, Rivadeneira F et.al.. 2012. Nature genetics. 44: 539-544

Craniofacial morphology but not excess body fat is associated with risk of having sleep-disordered breathing -The PANIC Study (a questionnaire-based inquiry in 6-8-year-olds)

Ikävalko T, Tuomilehto H, Pahkala R, Tompuri T, Laitinen T, Myllykangas R, Vierola A, Lindi V, Närhi M, Lakka TA. 2012. European journal of pediatrics. 171: 1747-1752

Determinants of pain and functioning in hip osteoarthritis - a two-year prospective study

Juhakoski R, Malmivaara A, Lakka TA, Tenhonen S, Hannila M-L, Arokoski JPA. 2012. Clinical rehabilitation. online: -

Diet, fitness and metabolic syndrome - The DR's EXTRA Study

Kouki R, Schwab U, Lakka TA, Hassinen M, Savonen K, Komulainen P, Krachler B, Rauramaa R. 2012. Nutrition metabolism and cardiovascular diseases. 22: 553-560

Dietary factors associated with overweight and body adiposity in Finnish children aged 6-8 years: the PANIC study

Eloranta A-M, Lindi V, Schwab U, Tompuri T, Kiiskinen S, Lakka H-M, Laitinen T, Lakka TA. 2012. International journal of obesity. 36: 950-955

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

Scott RA, Lagou V, Welch RP, Wheeler E, Montasser ME, Luan J, Mägi R, Strawbridge RJ, Rehnberg E, Gustafsson S, Kanoni S, Rasmussen-Torvik L, Yengo L, Lecoeur C, Shungin D, Sanna S, Sidore C, Johnson PCD, Jukema JW, Johnson T et.al.. 2012. Nature genetics. 44: 991-1005

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

Morris AP, Voight BF, Teslovich TM, Ferreira T, Segrè AV, Steinthorsdottir V, Strawbridge RJ, Khan H, Grallert H, Mahajan A, Prokopenko I, Kang HM, Dina C, Esko T, Fraser RM, Kanoni S, Kumar A, Lagou V, Langenberg C, Luan J et.al.. 2012. Nature genetics. 44: 981-990

Low-grade inflammation and depressive symptoms as predictors of abdominal obesity

Valtonen MK, Laaksonen DE, Laukkanen JA, Tolmunen T, Viinamäki H, Lakka H-M, Lakka TA, Niskanen L, Kauhanen J. 2012. Scandinavian journal of public health. 40: 674-680

New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism

Horikoshi M, Yaghootkar H, Mook-Kanamori DO, Sovio U, Taal HR, Hennig BJ, Bradfield JP, St Pourcain B, Evans DM, Charoen P, Kaakinen M, Cousminer DL, Lehtimäki T, Kreiner-Møller E, Warrington NM, Bustamante M, Feenstra B, Berry DJ, Thiering E et.al.. 2012. Nature genetics. -: 1-10

Purchase of antidepressant agents by patients with type 1 diabetes is associated with increased mortality rates in women but not in men

Ahola AJ, Harjutsalo V, Saraheimo M, Forsblom C, Groop PH; FinnDiane Study Group.. 2012. Diabetologia. 55: 73-79

Two-minute heart rate recovery after cycle ergometer exercise and all-cause mortality in middle-aged men

Savonen KP, Kiviniemi V, Laaksonen DE, Lakka TA, Laukkanen JA, Tuomainen T-P, Rauramaa R. 2012. Journal of internal medicine. 270: 589-596

Cardiorespiratory fitness in aging men and women: the DR's EXTRA study

Hakola L, Komulainen P, Hassinen M, Savonen K, Litmanen H, Lakka TA, Rauramaa R. 2011. Scandinavian journal of medicine and science in sports. 21: 679-687

Dietary factors and their associations with socioeconomic background in Finnish girls and boys 6-8 years of age: the PANIC Study

Eloranta AM, Lindi V, Schwab U, Kiiskinen S, Kalinkin M, Lakka HM, Lakka TA. 2011. European journal of clinical nutrition. 65: 1211-8

Fine mapping of five loci associated with low-density lipoprotein cholesterol detects variants that double the explained heritability

Sanna S, Li B, Mulas A, Sidore C, Kang HM, Jackson AU, Grazia Piras M, Usala G, Maninchedda G, Sassu A, Serra F, Palmas MA, Wood III WH, Njølstad I, Laakso M, Hveem K, Tuomilehto J, Lakka TA, Rauramaa R, Boehnke M,et al.. 2011. PLoS genetics. 7: e1002198

Food consumption, nutrient intake and the risk of having metabolic syndrome: the DR's EXTRA Study.

Kouki R, Schwab U, Hassinen M, Komulainen P, Heikkilä H, Lakka TA, Rauramaa R.. 2011. European journal of clinical nutrition. 65: 368-377

Liikunta. Käypä hoito -suositus

Kesäniemi A , Kettunen J, Ketola E, Kujala U, Kukkonen-Harjula K, Lakka T, Rauramaa R, Rauramo I, Tikkanen H, Vuori I. 2011. Duodecim. 127: 150-151

Physical activity attenuates the influence of FTO variants on obesity risk: A meta-analysis of 218,166 adults and 19,268 children

Kilpeläinen Tuomas O, Qi Lu, Brage Soren, Sharp Stephen J., Sonestedt Emily, Demerath Ellen, Ahmad Tariq, Mora Samia, Kaakinen Marika, Sandholt Camilla H, Holzapfel Christina, Autenrieth Christine S., Hyppönen Elina, Cauchi Stéphane , He Meian, Kutalik Zoltan, Kumari Meena, Stancaková Alena, Meidtner Karina, Balkau Beverley et al.. 2011. PLoS medicine. 8: e1001116

Physical activity, body composition and sleep in children

Lintu N, Himanen A, Karjalainen P, Elonranta A-M, Tompuri T, Viitasalo A, Laitinen T, Tuomilehto H, Lakka H-M, Lindi V, Lakka T. Teoksessa: Hakkarainen Anni, Liukkonen Jarmo, Linnamo Vesa(toim.) , 2011. International congress on enhancement of physical activity of children and youth 2011. s. 45. Jyväskylän yliopisto

Reproducibility of pulse contour analysis in children before and after maximal exercise stress test: The physical activity and nutrition in children (PANIC) study

Veijalainen A, Tompuri T, Lakka H-M, Laitinen T, & Lakka TA. 2011. Clinical physiology and functional imaging. 31: 132-138

The current standard measure of cardiorespiratory fitness introduces confounding by body mass: the DR's EXTRA study

Savonen K, Krachler B, Hassinen M, Komulainen P, Kiviniemi V, Lakka TA and Rauramaa R. 2011. International journal of obesity. 36: 1135-1140

Aikuisten liikunta

Kesäniemi A, Kettunen J, Ketola E, Kujala U, Kukkonen-Harjula K, Lakka T, Rauramaa R, Rauramo I, Tikkanen H & Vuori I. 2010. Duodecim. 126: 150-1

Cardiorespiratory fitness and metabolic syndrome in older men and women

Hassinen M, Lakka TA, Hakola L, Savonen K, Komulainen P, Litmanen H, Kiviniemi V, Kouki R, Heikkilä H, & Rauramaa R. 2010. Diabetes care. 33: 1655-1657

Cross-sectional analysis of baseline data to identify the major determinants of carotid intima-media thickness in a European population: the IMPROVE study

Baldassarre D, Nyyssönen K, Rauramaa R, de Faire U, Hamsten A, Smit AJ, Mannarino E, Humphries SE, Giral P, Grossi E, Veglia F, Paoletti R, Tremoli E; IMPROVE study group.. 2010. European heart journal. 614-22: 614-622

Exercise, fitness and cognition - A randomised controlled trial in older indivuals: The DR's EXTRA study

Komulainen P, Kivipelto M, Lakka TA, Savonen K, Hassinen M, Kiviniemi V, Hänninen T & Rauramaa R. 2010. European geriatric medicine. 1: 266-272

Lasten liikunta ja ravitsemus -tutkimus selvittää alakoululaisten elintapoja

Eloranta A-m, Lindi V, Schwab U, Kiiskinen S, Kalinkin M, Lintu N, Karjalainen P, Himanen A, Karjalainen J, Tompuri T, Viitasalo A, Lakka H-M, Lakka T & Lasten liikunta ja ravitsemus -tutkimus, Itä-Suomen yliopisto. 2010. BOLUS : RAVITSEMUSTERAPEUTTIEN YHDISTYKSEN LEHTI. : 30-33

Leisure-time physical activity and the metabolic syndrome in the Finnish diabetes prevention study

Ilanne-Parikka P, Laaksonen DE, Eriksson JG, Lakka TA, Lindström J, Peltonen M, Aunola S, Keinänen-Kiukaanniemi S, Uusitupa M & Tuomilehto J. On behalf of the Finnish diabetes prevention study group. 2010. Diabetes care. 33: 1610-1617

Reproducibility of pulse contour analysis in children before and after maximal exercise stress test: The Physical Activity and Nutrition in Children (PANIC) Study

Veijalainen A, Tompuri T, Lakka HM, Laitinen T & Lakka TA. 2010. Clinical physiology and functional imaging. online: 1-7

Sedentary lifestyle and emergence of hopelessness in middle-aged men

Valtonen M, Laaksonen DE, Laukkanen J, Tolmunen T, Rauramaa R, Viinamäki H, Mursu J, Savonen K, Lakka TA, Niskanen L & Kauhanen J. 2010. EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION AND REHABILITATION. 17: 524-9

Determinants of cardiorespiratory fitness in men aged 42 to 60 years with and without cardiovascular disease

Laukkanen JA, Laaksonen D, Lakka TA, Savonen K, Rauramaa R, Mäkikallio T, Kurl S. 2009. American journal of cardiology. 103: 1598-1604

Exercise and type 2 diabetes prevention

Hu G, Lakka TA, Barengo NC, Tuomilehto J. Teoksessa: Lignalli AT(toim.) , 2009. Handbook of Type 2 Diabetes in the Middle Aged and Elderly [E-Book]. s. 93-111. Nova Science Publisher

Kardiorespiratorinen suorituskyky ja metabolinen oireyhtymä

Hassinen M, Savonen K, Lakka TA, Komulainen P, Litmanen H, Kiviniemi V, Kouki R, Heikkilä H, Hakola L, Rauramaa R. 2009. Liikunta ja tiede. 46: 34-35

Kardiorespiratorinen suorituskyky muistin ennustajana ikääntyneillä miehillä ja naisilla

Komulainen P, Savonen K, Litmanen H, Lakka TA, Kiviniemi V, Hassinen M, Kivipelto M, Hänninen T, Heikkilä H, Kouki R, Hakola L, Rauramaa R. 2009. Liikunta ja tiede. 46: 41

Lasten ruokavaliossa on huolestuttavia piirteitä

Kiiskinen S, Schwab U, Kalinkin M, Lindi V, Tompuri T, Lakka H-M, Lakka T. 2009. Lääkärilehti. 64: 144-145

Leisure-time physical activity, cardiorespiratory fitness and feelings of hopelessness in men

Valtonen M, Laaksonen DE, Laukkanen J, Tolmunen T, Rauramaa R, Viinamäki H, Kauhanen J, Lakka T, Niskanen L. 2009. Bmc public health. 9:

Physical activity, fitness, and the preventioon of type 2 diabetes

Hu G, Lakka TA, Tuomilehto J. Teoksessa: Lee I-M(toim.) , 2009. Epidemiologic Methods in Physical Avtivity Studies. s. 201-224. Oxford University Press

Association of age and education with different types of leisure-time physical activity among 4437 Finnish adults

Borodulin K, Laatikainen T, Lahti-Koski M, Jousilahti P, Lakka TA. 2008. Journal of physical activity and health. 5: 242-251

BDNF is a novel marker of cognitive function in ageing women: the DR's EXTRA Study

Komulainen P, Pedersen M, Hänninen T, Bruunsgaard H, Lakka TA, Kivipelto M, Hassinen M, Rauramaa TH, Pedersen BK, Rauramaa R. 2008. Neurobiology of learning and memory. 90: 596-603

Cardiorespiratory fitness as a feature of metabolic syndrome in older men and women

Hassinen M, Lakka TA, Savonen K, Litmanen H, Kiviaho L, Laaksonen DE, Komulainen P, Rauramaa R. 2008. Diabetes care. 31: 1242-1247

Chronotropic incompetence and mortality in middle-aged men with known or suspected coronary heart disease

Savonen KP, Kiviniemi V, Laukkanen JA, Lakka TA, Rauramaa TH, Salonen JT, Rauramaa R. 2008. European heart journal. 29: 1896-1902

Dyslipidaemia as a predictor of hypertension in middle-aged men

Laaksonen DE, Niskanen L, Nyyssönen K, Lakka TA, Laukkanen JA, Salonen JT. 2008. European heart journal. 29: 2561-2568

Interaction of single nucleotide polymorphisms in ADRB2, ADRB3, TNF, IL6, IGF1R, LIPC, LEPR, and GHRL with physical activity on the risk of type 2 diabetes mellitus and changes in characteristics of the metabolic syndrome. The Finnish Diabetes Prevention Study

Kilpeläinen TO, Lakka TA, Laakosnen DE, Mager U, Salopuro T, Kubaszek A, Todorova B, Laukkanen O, Lindström J, Eriksson JG, Hämäläinen H, Aunola S, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Laakso M, Uusitupa M. 2008. Metabolism: clinical and experimental. 57: 428-436

Physical activity and diabetes complications in patients with type 1 diabetes. The Finnish Diabetic Nephropathy (FinnDiane) Study

Wadén J, Forsblom C, Thorn LM, Saraheimo M, Rosengård-Bärlund M, Heikkilä O, Lakka TA, Tikkanen H, Groop PH, FinnDiane Study Group, Karhapää P, Laakso M, Moilanen L, Niskanen L, Vauhkonen I, Voutilainen E. 2008. Diabetes care. 31: 230-232

Physical activity, fitness, and prevention of type 2 diabetes

Hu G, Lakka TA, Tuomilehto J. Teoksessa: Lee IM(toim.) , 2008. Epidemiologic Methods in Physical Activity Studies. s. 201-224. Oxford University Press

SNPs in PPARG associte with type 2 diabetes and intract with physival activity

Kilpeläinen TO, Lakka TA, Laaksonen DE, Lindström J, Eriksson JG, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Lindi V, Tuomilehto J, Uusitupa M, Laakso M. 2008. Medicine and science in sports and exercise. 40: 25-33

Usefulness of chronotropic incompetence in response to exercise as a predictor of myocardial infarction in middle-aged men without cardiovascular disease

Savonen KP, Lakka TA, Laukkanen JA, Rauramaa TH, Salonen JT, Rauramaa R. 2008. American journal of cardiology. 101: 992-998

Workload at the heart rate of 100 beats/min and mortality in middle-aged men known or suspected coronary heart disease

Savonen KP, Lakka TA, Laukkanen JA, Rauramaa TH, Salonen JT, Rauramaa R. 2008. Heart. 94: E14

Association of waist and hip circumference with 12-year progression of carotid intima-media thickness in elderly women

Hassinen M, Lakka TA, Komulainen P, Haapala I, Nissinen A, Rauramaa R. 2007. International journal of obesity. 31: 1406-1411

Carotid intima-media thickness and cognitive function in elderly women: a population-based study

Komulainen P, Kivipelto M, Lakka TA, Hassinen M, Helkala E-L, Patja K, Nissinen A, Rauramaa R. 2007. Neuroepidemiology. 28: 207-213

Effectiveness of workload at the heart rate of 100 beats/min in predicting cardiovascular mortality in men aged 42, 48, 54, or 60 years at baseline

Savonen KP, Lakka TA, Laukkanen JA, Rauramaa TH, Salonen JT, Rauramaa R. 2007. American journal of cardiology. 100: 563-568

Epidemiological studies of exercise in diabetes prevention

Hu G, Lakka TA, Kilpeläinen T, Tuomilehto J. 2007. Applied physiology nutrition and metabolism-physiologie appliquee nutrition et metabolisme. 32: 583-595

Leisure-time physical activity is associated with the metaboic syndrome in type 1 diabetes: Effect of the PPAR-gamma Pro12Ala polymorphism: the FinnDiane Study

Wadén J, Thorn LM, Forsblom C, Lakka T, Saraheimo M, Rosengård-Bärlund M, Heikkilä O, Wessman M, Turunen JA, Parkkonen M, Tikkanen H, Groop P-H, on behalf of the FinnDiane Study Group. 2007. Diabetes care. 30: 1618-1620

Metabolic syndrome and cognitive function: a population-based follow-up study in elderly women

Komulainen P, Lakka TA, Kivipelto M, Hassinen M, Helkala E-L, Haapala I, Nissinen A, Rauramaa R. 2007. Dementia and geriatric cognitive disorders. 23: 29-34

Obesity, physical activity, and nutrition in the metabolic syndrome

Hu G, Lakka TA, Lakka H-M, Tuomilehto J, Lakka TA. Teoksessa: Krentz AJ, Wong ND(toim.) , 2007. Metabolic Syndrome and Cardiovascular Disease. s. 241-278. Informa Healthcare

Occupational, commuting and leisure-time physical activity in relation to coronary heart disease among middle-aged Finnish men and women

Hu G, Jousilahti P, Borodulin K, Barengo NC, Lakka TA, Nissinen A, Tuomilehto J. 2007. Atherosclerosis. 194: 490-497

Physical activity in prevention and treatment of the metabolic syndrome

Lakka TA, Laaksonen DE. 2007. Applied physiology nutrition and metabolism-physiologie appliquee nutrition et metabolisme. 32: 76-88

Physical activity modifies the effect of SNPs in the SLC2A2 (GLUT2) and ABCC8 (SUR1) genes on the risk of developing type 2 diabetes

Kilpeläinen TO, Lakka TA, Laaksonen DE, Laukkanen O, Lindström J, Eriksson JG, Valle TT, Hämäläinen H, Aunola S, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Uusitupa M, Laakso M, for the Finnish Diabetes Prevention Study Group, Laakso M. 2007. Physiological genomics. 31: 264-272

Serum high sensitivity C-reactive protein and cognitive function in elderly women

Komulainen P, Lakka TA, Kivipelto M, Hassinen M, Penttilä IM, Helkala E-L, Gylling H, Nissinen A, Rauramaa R. 2007. Age and ageing. 36: 443-448

Association of leisure time physical activity abdomimal obesity with fsting serum insulin and 2-h postchallenge plasma glucose levels

Borodulin K, Tuomilehto J, Peltonen M, Lakka TA, Sundvall J, Jousilahti P. 2006. Diabetic medicine. 23: 1025-1028

C-reactive protein and metabolic syndrome in elderly women. A 12-year follow-up study

Hassinen M, Lakka TA, Komulainen P, Gylling H, Nissinen A, Rauramaa R. 2006. Diabetes care. 29: 931-932

Different forms of physical activity and cardiovascular risk factors among 24-64-year-old men and women in Finland

Barengo NC, Kastarinen M, Lakka T, Nissinen A, Tuomilehto J. 2006. EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION AND REHABILITATION. 13: 51-59

Exercise, genetics and prevention of type 2 diabetes

Hu G, Rico-Sanz J, Lakka TA, Tuomilehto J. 2006. Essays in biochemistry. 42: 177-192

Heart rate response during exercise test and cardiovascular mortality in middle-aged men

Savonen KP, Lakka TA, Laukkanen JA, Halonen PM, Rauramaa TH, Salonen JT, Rauramaa R. 2006. European heart journal. 27: 582-588

High dietary methionine intake increases the risk of acute coronary events in middle-aged men

Virtanen JK, Voutilainen S, Rissanen TH, Happonen P, Mursu J, Laukkanen JA, Poulsen H, Lakka TA, Salonen JT. 2006. Nutrition metabolism and cardiovascular diseases. 16: 113-120

Letter to the editor (Exercise and inflammation: reply)

Lakka TA, Lakka H-M, Rankinen T, Bouchard C. 2006. European heart journal

Lifestyle management in the metabolic syndrome

Hu G, Lakka TA, Lakka H-M, Tuomilehto J. 2006. Metabolic syndrome and related disorders. 4: 270-286

Metabolic syndrome and the progression of carotid intima-media thickness in elderly women

Hassinen M, Komulainen P, Lakka TA, Väisänen SB, Haapala I, Gylling H, Alen M, Schmidt-Trucksäss A, Nissinen A, Rauramaa R. 2006. Archives of internal medicine. 166: 444-449

Peak oxygen pulse during exercise as a predictor for coronary heart disease and all cause death

Laukkanen JA, Kurl S, Salonen JT, Lakka TA, Rauramaa R. 2006. Heart. 92: 1219-1224

Quantitative trait locus on chromosme 20q13 for plasma levels of C-reactive protein in healthy whites: the HERITAGE family sudy

Lakka TA, Rankinen T, Rice T, Leon AS, Rao DC, Skinner JS, Bouchard C. 2006. Physiological genomics. 27: 103-107

Systemic immune mediators and lifestyle changes in the prevention of type 2 diabetes. Results from the Finnish diabes prevention study

Herder C, Peltonen M, Koenig W, Kräft I, Mûller-Scholze S, Martin S, Lakka T, Ilanne-Parikka P, Eriksson JG, Hämäläinen H, Keinänen-Kiukaanniemi S, Valle TT, Uusitupa M, Lindström J, Kolb H, Tuomilehto J. 2006. Diabetes. 55: 2340-2346

The TNF-a G-308A polymorphism is associated with C-reactive protein levels: The HERITAGE Family Study

Lakka H-M, Lakka TA, Rankinen T, Rice T, Rao DC, Leon AS, Skinner JS, Bouchard C. 2006. Vascular pharmacology. 44: 377-383

Associations between estimated aerobic fitness and cardiovascular risk factors in adults with different levels of abdominal obesity

Borodulin K, Laatikainen T, Lahti-Koski M, Lakka TA, Laukkanen R, Sarna S, Jousilahti P. 2005. EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION AND REHABILITATION. 12: 126-131

Associations of body composition and physical activity with balance and walking ability in the elderly

Hassinen M, Komulainen P, Lakka TA, Väisänen SB, Rauramaa R. 2005. Journal of physical activity and health. 3: 298-306

Effect of exercise training on plasma levels of C-reactive protein in healthy adults: the HERITAGE family study

Lakka TA, Lakka H-M, Rankinen T, Leon AS, Rao DC, Skinner JS, Wilmore JH, Bouchard C. 2005. European heart journal. 26: 2018-2025

Effects of exercise training on glucose homeostasis. The Heritage family studies

Boulé NG, Weisnagel SJ, Lakka TA, Tremblay A, Bergman RN, Rankinen T, Leon AS, Skinner JS, Wilmore JH, Rao DC, Bouchard C. 2005. Diabetes care. 28: 108-114

Low physical activity as a predictor for antihypertensive drug treatment in 25- 64-year-old populations in Eastern and south-western Finland

Barengo NC, Hu G, Kastarinen M, Lakka TA, Pekkarinen H, Nissinen A, Tuomilehto J. 2005. Journal of hypertension. 23: 293-299

Physical activity in the prevention of type 2 diabetes. The Finnish diabetes prevention study

Laaksonen DE, Lindström J, Lakka TA, Eriksson JG, Niskanen L, Wikström K, Aunola S, Keinänen-Kiukaanniemi S, Laakso M, Valle TT, Ilanne-Parikka P, Louheranta A, Hakumäki M, Kaikkonen H, Härkönen P, Sundvall J, Tuomilehto J, Uusitupa M, Louheranta A. 2005. Diabetes. 54: 158-165

Physical activity, cardiovascular risk factors, and mortality among Finnish adults with diabetes

Hu G, Jousilahti P, Barengo NC, Qiao Q, Lakka TA, Tuomilehto J. 2005. Diabetes care. 28: 799-805

Protein tyrosine phosphatase 1B variant associated with fat distribution and insulin metabolism

Ukkola O, Rankinen T, Lakka T, Leon AS, Skinner JS, Wilmore JH, Rao DC, Kesäniemi YA, Bouchard C. 2005. Obesity. 13: 829-834

Epidemiology and treatment of the metabolic syndrome

Laaksonen DE, Niskanen L, Lakka H-M, Lakka TA, Uusitupa M, Laaksonen DE. 2004. Annals of medicine. 36: 332-346

Low physical activity as a predictor for total and cardiovascular disease mortality in middle-aged men and women in Finland

Barengo NC, Hu G, Lakka TA, Pekkarinen H, Nissinen A, Tuomilehto J. 2004. European heart journal. 25: 2204-2211

Physical activity in the prevention of type 2 diabetes

Hu G, Lakka TA, Barengo NC, Tuomilehto J. 2004. KARDIOVASKULÄRE MEDIZIN. 7: 394-405

Relationship of physical activity and body mass index to the risk of hypertension: a prospective study in Finland

Hu G, Barengo NC, Tuomilehto J, Lakka TA, Nissinen A, Jousilahti P. 2004. Hypertension. 43: 25-30

Systolic blood pressure during recovery from exercise and the risk of acute myocardial infarction in middle-aged men

Laukkanen JA, Kurl S, Salonen R, Lakka TA, Rauramaa R, Salonen JT. 2004. Hypertension. 44: 820-825

Cardiorespiratory fitness and vigorous leisure-time physical activity modify the association of small size at birth with the metabolic syndrome

Laaksonen DE, Lakka H-M, Lynch J, Lakka TA, Niskanen L, Rauramaa R, Salonen JT, Kauhanen J. 2003. Diabetes care. 26: 2156-2164

Sedentary lifestyle, poor cardiorespiratory fitness, and the metabolic syndrome

Lakka TA, Laaksonen DE, Lakka H-M, Männikkö N, Niskanen LK, Rauramaa R, Salonen JT. 2003. Medicine and science in sports and exercise. 35: 1279-1286

Abdominal obesity is associated with accelerated progression of carotid atherosclerosis in men

Lakka TA, Lakka H-M, Salonen R, Kaplan GA, Salonen JT. 2001. Atherosclerosis. 154: 497-504

Cardiovascular fitness as a predictor of mortality in men

Laukkanen JA, Lakka TA, Rauramaa R, Kuhanen R, Venäläinen JM, Salonen R, Salonen JT. 2001. Archives of internal medicine. 161: 825-831

Leisure-time physical activity and rate of bone loss among peri- and postmenopausal women: a longitudinal study

Puntila E, Kröger H, Lakka T, Tuppurainen M, Jurvelin J, Honkanen R. 2001. Bone. 29: 442-446

Liikuntaa sepelvaltimotaudin ehkäisyyn ja hoitoon

Rauramaa R, Lakka TA. 2001. Duodecim. 117: 633-638

Low dietary folate intake is associated with an excess incidence of acute coronary events. The Kuopio Ischemic Heart Disease Risk Factor Study

Voutilainen S, Rissanen TH, Virtanen J, Lakka TA, Salonen JT. 2001. Circulation. 103: 2674-2680

Risk of acute coronary events and serum concentration of asymmetrical dimethylarginine

Valkonen V-P, Päivä H, Salonen JT, Lakka TA, Lehtimäki T, Laakso J, Laaksonen R. 2001. The Lancet. 358: 2127-2128

Low serum folate concentrations are associated with an excess incidence of acute coronary events: the Kuopio Ischaemic Heart Disease Risk Factor Study

Voutilainen S, Lakka TA, Porkkala-Sarataho E, Rissanen T, Kaplan GA, Salonen JT. 2000. European journal of clinical nutrition. 54: 424-428

Risk of acute coronary events according to serum concentrations of enterolactone: a prospective population-based case-control study

Vanharanta M, Voutilainen S, Lakka TA, van der Lee M, Adlercreutz H, Salonen JT. 1999. The Lancet. 354: 2112-2115

Hyperinsulinemia is associated with the incidence of hypertension and dyslipidemia in middle-aged men

Salonen JT, Lakka TA, Lakka H-M, Valkonen V-P, Everson SA, Kaplan GA. 1998. Diabetes. 47: 270-275

Weight gain and the risk of developing insulin resistance syndrome

Everson SA, Goldberg DE, Helmrich SP, Lakka TA, Lynch JW, Kaplan GA, Salonen JT. 1998. Diabetes care. 21: 1637-1643

Body iron stores are associated with serum insulin and blood glucose concentrations

Tuomainen T-P, Nyyssönen K, Salonen R, Tervahauta A, Korpela H, Lakka T, Kaplan GA, Salonen JT. 1997. Diabetes care. 20: 426-428

Frequent hangovers and cardiovascular mortality in middle-aged men

Kauhanen J, Kaplan GA, Goldberg DD, Cohen RD, Lakka TA, Salonen JT. 1997. Epidemiology. 8: 310-314

Physical activity in adolescence and bone density in peri- and postmenopausal women: A population-based study

Puntila E, Kröger H, Lakka T, Honkanen R, Tuppurainen M. 1997. Bone. 21: 363-367

The physical activity questionnaires of the Kuopio Ischemic Heart Disease Risk Factor Study (KIHD)

Lakka TA, Salonen JT. 1997. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE. SUPPLEMENT. 29: S46-S58

Conditioning leisure time physical activity and cardiorespiratory fitness in sociodemographic groups of middle-aged men in Eastern Finland

Lakka TA, Kauhanen J, Salonen JT. 1996. International journal of epidemiology. 25: 86-93

Hyperinsulinemia and the risk of coronary heart disease

Lakka TA, Lakka H-M, Salonen JT. 1996. The new england journal of medicine

Moderately intense physical activities and high levels of cardiorespiratory fitness reduce the risk of non-insulin-dependent diabetes mellitus in middle-aged men

Lynch J, Helmrich SP, Lakka TA, Kaplan GA, Cohen RD, Salonen R, Salonen JT. 1996. Archives of internal medicine. 156: 1307-1314

Religious affiliation and all-cause mortality: a prospective population study in middle-aged men in Eastern Finland

Räsänen J, Kauhanen J, Lakka TA, Kaplan GA, Salonen JT. 1996. International journal of epidemiology. 25: 1244-1249

Higher levels of conditioning leisure time physical activity are associated with reduced levels of stored iron in Finnish men

Lakka TA, Nyyssönen K, Salonen JT. 1994. American journal of epidemiology. 140: 148-160

Relation of leisure-time physical activity and cardiorespiratory fitness to the risk of acute myocardial infarction in men

Lakka TA, Venäläinen JM, Rauramaa R, Salonen R, Tuomilehto J, Salonen JT. 1994. The new england journal of medicine. 330: 1549-1554

Tarkenna hakuasi

Tutkimusryhmät

Accelerated early childhood growth associates with the development of earlier adrenarche and puberty

Accumulating Sedentary Time and Physical Activity From Childhood to Adolescence and Cardiac Function in Adolescence

Associations of Lifestyle Patterns with Glucose and Lipid Metabolism in Finnish Adults at Increased Risk of Type 2 Diabetes

Luonnossa vietetyn ajan ja liikunnan yhteydet positiiviseen mielenterveyteen työelämän ulkopuolella olevilla pohjoissavolaisilla

Maternal gestational hypertension, smoking and pre‐eclampsia are associated with metabolic dysfunction‐associated fatty liver disease in overweight offspring

Prenatal Urban Environment and Blood Pressure Trajectories From Childhood to Early Adulthood

The associations of depressive symptoms and perceived stress with arterial health in adolescents

Alanine aminotransferase cutoffs for the pediatric fatty liver disease: Major impact of the reference population

Associations Between Engagement with the BitHabit Digital Lifestyle Intervention and Changes in Type 2 Diabetes Risk Factors

Associations between physical fitness and cerebellar gray matter volume in adolescents

Associations of diet quality and food consumption with serum biomarkers for lipid and amino acid metabolism in Finnish children: the PANIC study

Bone mineral density loci specific to the skull portray potential pleiotropic effects on craniosynostosis

Cross-Lagged Associations between Physical Activity, Motor Performance, and Academic Skills in Primary-School Children

Cross-sectional associations between physical fitness and biomarkers of inflammation in children—The PANIC study

Developmental models of motor-evoked potential features by transcranial magnetic stimulation across age groups from childhood to adulthood

Digitaalisella hyvinvointisovelluksella voidaan mitata mielen hyvinvointia ja elintapoja sekä toteuttaa näiden edistämistä tukevia interventioita

Effects of 2-Year Physical Activity and Dietary Intervention on Adrenarchal and Pubertal Development: The PANIC Study

Effects of 2‐year dietary and physical activity intervention on cognition in children—a nonrandomized controlled trial

European fitness landscape for children and adolescents: updated reference values, fitness maps and country rankings based on nearly 8 million test results from 34 countries gathered by the FitBack network

Evidence for protein leverage in a general population sample of children and adolescents

Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci

Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake

Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth

Impaired cardiorespiratory and neuromuscular fitness in children and adolescents with juvenile idiopathic arthritis: a cross-sectional case-control study in the era of biologic drug therapies

Parempaa mielenterveyden edistämistä Pohjois-Savossa kuntien mielenterveysjohtamisen käsitettä ja tavoitteita täsmentämällä sekä tiedolla johtamista kehittämällä

Prevalence and associated factors of metabolic-associated fatty liver disease in overweight Finnish children and adolescents

Promotive and preventive interventions for mental health and well-being in adult populations: a systematic umbrella review

A participatory arts programme – Shared experience for family caregivers and care recipients

A quantitative ultra-performance liquid chromatography high-resolution mass spectrometry analysis of steroids from human scalp hair

ACE2 expression in adipose tissue is associated with cardio-metabolic risk factors and cell type composition—implications for COVID-19

Associations between weight loss history and factors related to type 2 diabetes risk in the Stop Diabetes study

Associations of diet quality, food consumption, eating frequency, and eating behaviour with dental caries experience in Finnish children: A 2-year longitudinal study

Cross-sectional associations between cardiorespiratory fitness and NMR-derived metabolic biomarkers in children – the PANIC study

Determinants of Cognitive Performance in Children and Adolescents : A Populational Longitudinal Study

Digitally Supported Lifestyle Intervention to Prevent Type 2 Diabetes Through Healthy Habits: Secondary Analysis of Long-Term User Engagement Trajectories in a Randomized Controlled Trial

Is low cardiorespiratory fitness a feature of metabolic syndrome in children and adults?

Lapsuuden suun terveydenhuollon käynnit ja vanhempien sosioekonominen asema

LongITools: Dynamic longitudinal exposome trajectories in cardiovascular and metabolic noncommunicable diseases

Mielenterveys- ja päihdeongelmat työelämän ulkopuolella olevilla pohjoissavolaisilla

Physical activity volume and intensity distribution in relation to bone, lean and fat mass in children

Prevalence of erosive tooth wear and associated dietary factors among a group of Finnish adolescents

Real-world effectiveness of digital and group-based lifestyle interventions as compared with usual care to reduce type 2 diabetes risk – A stop diabetes pragmatic randomised trial

Sources of vitamin D and determinants of serum 25-hydroxyvitamin D in Finnish adolescents

The Composition and Functional Capacities of Saliva Microbiota Differ Between Children With Low and High Sweet Treat Consumption

The Mediating Role of Endocrine Factors in the Positive Relationship Between Fat Mass and Bone Mineral Content in Children Aged 9–11 Years: The Physical Activity and Nutrition in Children Study

The effects of an 8-year individualised lifestyle intervention on food consumption and nutrient intake from childhood to adolescence: the PANIC Study

Työelämän ulkopuolella olevien positiivista mielenterveyttä tulee parantaa edistämällä terveellisiä elintapoja ja tarjoamalla matalan kynnyksen palveluita

Associations of physical activity, sedentary time, and diet quality with biomarkers of inflammation in children

Comparison of Communication Channels for Large-Scale Type 2 Diabetes Risk Screening and Intervention Recruitment: Empirical Study

Cost-effectiveness of physical activity intervention in children - results based on the Physical Activity and Nutrition in Children (PANIC) study

Dental caries among Finnish teenagers participating in physical activity and diet intervention: association with anthropometrics and behavioural factors

Enhanced Eating Competence Is Associated with Improved Diet Quality and Cardiometabolic Profile in Finnish Adults with Increased Risk of Type 2 Diabetes

Exercise, diet, and cognition in a 4-year randomized controlled trial: Dose-Responses to Exercise Training (DR's EXTRA)

Hyvällä mielellä Pohjois-Savo -hankkeen esiselvitys: Toimenpide-ehdotus ja vaikuttavuuden arviointisuunnitelma

Liikunnallisuus ja hyvä kunto ehkäisevät tyypin 2 diabetesta ja valtimotautien riskitekijöitä lapsuudesta lähtien

Longitudinal and cross-sectional associations of adherence to 24-hour movement guidelines with cardiometabolic risk

Longitudinal associations of physical activity, sedentary time, and cardiorespiratory fitness with arterial health in children - the PANIC study

Multi-ancestry genome-wide association study accounting for gene-psychosocial factor interactions identifies novel loci for blood pressure traits

Oxygen-18 and Carbon-13 isotopes in eCO 2 and erythrocytes carbonic anhydrase activity of Finnish prediabetic population

Plasma irisin and its associations with oxidative stress in athletes suffering from overtraining syndrome

Response

Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability

The Positive Relationship between Moderate-to-Vigorous Physical Activity and Bone Mineral Content Is Not Mediated by Free Leptin Index in Prepubertal Children: The PANIC Study

The independent and interactive associations of physical activity intensity and vitamin D status with bone mineral density in prepubertal children: the PANIC Study

The trans-ancestral genomic architecture of glycemic traits

A 2 year physical activity and dietary intervention attenuates the increase in insulin resistance in a general population of children: the PANIC study

An overview on the associations between health behaviors and brain health in children and adolescents with special reference to diet quality

Associations between cardiorespiratory fitness, motor competence, and adiposity in children

Associations of dietary carbohydrate and fatty acid intakes with cognition among children

Child-related and Parental Predictors for Thelarche in a General Population of Girls: The PANIC Study

Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

Effects of a 2-Year Lifestyle Intervention on Cardiorespiratory Fitness in 6-8- Year-Old Children: The PANIC Study

Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci

Leisure-time cross-country skiing and the risk of venous thromboembolism: A prospective cohort study

Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits

Primary hand motor representation areas in healthy children, preadolescents, adolescents, and adults

StopDia-hankkeesta vinkkejä terveyden edistämiseen ja hyte-johtamiseen