TIMO LEPPäNEN

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Avainsanat

TUTKIMUSRYHMÄT - UEF

• 
  Sleep Technology and Analytics Group (STAG)

Linkit

• LinkedIn Timo Leppänen
• Research gate Timo Leppänen
• Orcid Timo Leppänen
• Linkki Sleep Technology and Analytics Group (STAG)

Julkaisut

• Huttunen, R; Leppänen, T; Duce, B; Oksenberg, A; Myllymaa, S; Töyrös, J; Korkalainen, H. 2021. Assessment of Obstructive Sleep Apnea-Related Sleep Fragmentation Utilizing Deep Learning-Based Sleep Staging from Photoplethysmography Sleep [ACCEPTED MANUSCRIPT 5.6.21]: 26 s.. 2021
• Karhu, T; Myllymaa, S; Nikkonen, S; Mazzotti, DR; Kulkas, A; Töyräs, J; Leppänen, T. 2021. Diabetes and cardiovascular diseases are associated with the worsening of intermittent hypoxaemia Journal of sleep research [First published: 10 August 2021]: 1-11. 2021
• Karhu, Tuomas; Myllymaa, Sami; Nikkonen, Sami; Mazzotti, Diego R; Töyräs, Juha; Leppänen, Timo. 2021. Longer and Deeper Desaturations Are Associated With the Worsening of Mild Sleep Apnea: The Sleep Heart Health Study Frontiers in neuroscience 15: 657126. 2021
• Korkalainen, Henri; Leppänen, Timo; Duce, Brett; Kainulainen, Samu; Aakko, Juhani; Leino, Akseli; Kalevo, Laura; Afara, Isaac O; Myllymaa, Sami; Töyräs, Juha. 2021. Detailed assessment of sleep architecture with deep learning and shorter epoch-to-epoch duration reveals sleep fragmentation of patients with obstructive sleep apnea IEEE journal of biomedical and health informatics 25 7: 2567-2574. 2021
• Leino, Akseli; Nikkonen, Sami; Kainulainen, Samu; Korkalainen, Henri; Töyräs, Juha; Myllymaa, Sami; Leppänen, Timo; Ylä-Herttuala, Salla; Westeren-Punnonen, Susanna; Muraja-Murro, Anu; Jäkälä, Pekka; Mervaala, Esa; Myllymaa, Katja. 2021. Neural network analysis of nocturnal SpO2 signal enables easy screening of sleep apnea in patients with acute cerebrovascular disease Sleep medicine 79: 71-78. 2021
• Nikkonen, Sami; Korkalainen, Henri; Leino, Akseli; Myllymaa, Sami; Duce, Brett; Leppänen, Timo; Töyräs, Juha. 2021. Automatic Respiratory Event Scoring in Obstructive Sleep Apnea Using a Long Short-Term Memory Neural Network IEEE journal of biomedical and health informatics 25 8: 2917-2927. 2021
• Oksenberg, Arie; Goizman, Vlada; Eitan, Edith; Nasser, Kitham; Gadoth, Natan, Leppänen, Timo. 2021. How sleepy patients differ from non-sleepy patients in mild obstructive sleep apnea? Journal of sleep research First published: 29 July 2021: e13431. 2021
• Rissanen, M; Oksenberg, A; Töyräs, J; Myllymaa, S; Leppänen, T. 2021. Total durations of respiratory events are modulated within REM and NREM sleep by sleeping position and obesity in OSA patients Sleep medicine 81: 394-400. 2021
• Kainulainen, Samu; Korkalainen, Henri; Sigurdardottir, Sigriur; Myllymaa, Sami; Serwatko, Marta; Sigurdardottir, Sigurveig Pora; Clausen, Michael; Leppänen, Timo; Arnardottir, Erna Sif. 2021. Comparison of EEG Signal Characteristics Between Polysomnography and Self Applied Somnography Setup in a Pediatric Cohort IEEE access 9: 110916-110926. 2021
• Kulkas, Antti; Duce, Brett; Töyräs, Juha; Seppä, Juha; Leppänen, Timo. 2020. Comparison of the effect of weight change, simulated computational continuous positive airway pressure treatment and positional therapy on severity of sleep apnea Journal of sleep research 2021; 30 2: e13070. 2020
• Nikkonen, Sami; Korkalainen, Henri; Kainulainen, Samu; Myllymaa, Sami; Leino, Akseli; Kalevo, Laura; Oksenberg, Arie; Leppänen, Timo; Töyräs, Juha. 2020. Estimating daytime sleepiness with previous night EEG, EOG and EMG spectrograms in patients with suspected sleep apnea using a convolutional neural network Sleep 43 12: zsaa106. 2020
• Leppänen, T; Kulkas, A; Töyräs, J; Myllymaa, S; Gadoth, N; Oksenberg, A. 2020. Polysomnographic characteristics of severe obstructive sleep apnea vary significantly between hypertensive and normotensive patients of both genders Sleep and breathing 2021; 25 1: 105-116. 2020
• Leino, A; Westeren-Punnonen, S; Töyräs, J; Myllymaa, S; Leppänen, T; Ylä-Herttuala, S; Muraja-Murro, A; Kantanen, AM; Autere, J; Jäkälä, P; Mervaala, E; Myllymaa, K. 2020. Acute stroke and TIA patients have specific polygraphic features of obstructive sleep apnea Sleep and breathing 24 4: 1495-1505. 2020
• Kainulainen, Samu; Duce, Brett; Korkalainen, Henri; Leino, Akseli; Huttunen, Riku; Kalevo, Laura; Arnardottir, Erna S; Kulkas, Antti; Myllymaa, Sami; Töyräs, Juha; Leppänen, Timo. 2020. Increased nocturnal arterial pulsation frequencies of obstructive sleep apnoea patients is associated with an increased number of lapses in a psychomotor vigilance task ERJ open research 6 4: 00277-202. 2020
• Korkalainen, H; Aakko, J; Duce, B; Kainulainen, S; Leino, A; Nikkonen, S; Afara, I O; Myllymaa, S; Töyräs, J; Leppänen, T. 2020. Deep learning enables sleep staging from photoplethysmogram for patients with suspected sleep apnea Sleep 43 11: zsaa098. 2020
• Kalevo, Laura; Miettinen, Tomi; Leino, Akseli; Kainulainen, Samu; Korkalainen, Henri; Myllymaa, Katja; Töyräs, Juha; Leppänen, Timo; Laitinen, Tiina; Myllymaa, Sami. 2020. Effect of sweating on electrode-skin contact impedances and artifacts in EEG recordings with various screen-printed Ag/Agcl electrodes IEEE access 8: 50934-50943. 2020
• Kainulainen, Samu; Töyräs, Juha; Oksenberg, Arie; Korkalainen, Henri; Afara, Isaac O; Leino, Akseli; Kalevo, Laura; Nikkonen, Sami; Gadoth, Natan; Kulkas, Antti; Myllymaa, Sami; Leppänen, Timo. 2020. Power spectral densities of nocturnal pulse oximetry signals differ in OSA patients with and without daytime sleepiness Sleep medicine 73: 231-237. 2020
• Kainulainen, S; Duce, B; Korkalainen, H; Oksenberg, A; Leino, A; Arnardottir, E; Kulkas, A; Myllymaa, S; Töyräs, J; Leppänen, T. 2020. Severe Desaturations Increase PVT-based Median Reaction Time and Number of Lapses in OSA Patients European respiratory journal 55: 1901849. 2020
• Hietakoste, Salla; Korkalainen, Henri; Kainulainen, Samu; Sillanmäki, Saara; Nikkonen, Sami; Myllymaa, Sami; Duce, Brett; Töyräs, Juha; Leppänen, Timo. 2020. Longer apneas and hypopneas are associated with greater ultra-short-term HRV in obstructive sleep apnea Scientific reports 10: 21556. 2020
• Nikkonen, S; Afara, IO; Leppänen, T; Töyräs, J. 2019. Artificial neural network analysis of the oxygen saturation signal enables accurate diagnostics of sleep apnea Scientific reports 9 1: 13200. 2019
• Oksenberg, A; Goizman, V; Eitan, E; Nasser, K; Gadoth, N; Leppänen, T. 2019. Obstructive sleep apnea: Do positional patients become nonpositional patients with time? Laryngoscope 130 9: 2263-2268. 2019
• Oksenberg, A; Gadoth, N; Töyräs, J; Leppänen, T. 2019. Prevalence and characteristics of positional obstructive sleep apnea (POSA) in patients with severe OSA Sleep and breathing 2020; 24 2: 551-559. 2019
• Nikkonen, S; Töyräs, J; Mervaala, E; Myllymaa, S; Terrill, P; Leppänen, T. 2019. Intra-night variation in apnea-hypopnea index affects diagnostics and prognostics of obstructive sleep apnea Sleep and breathing 2020; 24: 379-386. 2019
• Kainulainen, S; Töyräs, J; Oksenberg, A; Korkalainen, H; Sefa, S; Kulkas, A; Leppänen, T. 2019. Severity of desaturations reflects OSA-related daytime sleepiness better than AHI Journal of clinical sleep medicine 15 8: 1135-1142. 2019
• Leppänen, Timo; Kulkas, Antti; Töyräs, Juha. 2019. The hypoxic burden: also known as the desaturation severity parameter European heart journal 40 35: 2991-2993. 2019
• Korkalainen, Henri; Aakko, Juhani; Nikkonen, Sami; Kainulainen, Samu; Leino, Akseli; Duce, Brett; Afara, Isaac Oluwaseun; Myllymaa, Sami; Töyräs, Juha; Leppänen, Timo. 2019. Accurate Deep Learning-Based Sleep Staging in a Clinical Population with Suspected Obstructive Sleep Apnea IEEE journal of biomedical and health informatics 24 7: 2073-2081. 2019
• Korkalainen, H; Töyräs, J; Nikkonen, S; Leppänen, T. 2019. Mortality-risk-based apnea-hypopnea index thresholds for diagnostics of obstructive sleep apnea Journal of sleep research 28 6: e12855. 2019
• Kalevo, Laura; Miettinen, Tomi; Leino, Akseli; Kainulainen, Samu; Myllymaa, Katja; Toyras, Juha; Leppanen, Timo; Myllymaa, Sami. 2019. Improved Sweat Artifact Tolerance of Screen-Printed EEG Electrodes by Material Selection-Comparison of Electrochemical Properties in Artificial Sweat IEEE access 7: 133237-133247. 2019
• Kulkas, Antti; Nikkonen, Sami; Töyräs, Juha; Mervaala, Esa; Leppänen, Timo. 2018. Simulation of Required CPAP Usage to Normalize AHI in Obstructive Sleep Apnea Patients. Teoksessa: Lhotska, L; Sukupova, L; Lackovic, I; Ibbott, G (toim.), World Congress on Medical Physics and Biomedical Engineering 2018, June 3-8, 2018, Prague, Czech Republic (Vol.2). Springer. IFMBE Proceedings 68/2. s. 129-132. 2018
• Leppänen, Timo; Kulkas, Antti; Mervaala, Esa; Töyräs, Juha. 2018. Increase in Body Mass Index Decreases Duration of Apneas and Hypopneas in Obstructive Sleep Apnea Respiratory care 2019; 64 1: 77-84. 2018
• Leppänen, Timo; Kulkas, Antti; Oksenberg, Arie; Duce, Brett; Mervaala, Esa; Töyräs, Juha. 2018. Differences in arousal probability and duration after apnea and hypopnea events in adult obstructive sleep apnea patients PHYSIOLOGICAL MEASUREMENT 39 11: 114004. 2018
• Ryynänen, Olli-Pekka; Leppänen, Timo; Kekolahti, Pekka; Mervaala, Esa; Töyräs, Juha. 2018. Bayesian Network Model to Evaluate the Effectiveness of Continuous Positive Airway Pressure Treatment of Sleep Apnea Healthcare Informatics Research 24 4: 346-358. 2018
• Kulkas Antti, Duce Brett, Leppänen Timo, Hukins Craig, Töyräs Juha. 2017. Gender differences in severity of desaturation events following hypopnea and obstructive apnea events in adults during sleep. PHYSIOLOGICAL MEASUREMENT 38 8: 1490-1502. 2017
• Kulkas Antti, Duce Brett, Leppänen Timo, Hukins Craig, Töyräs Juha. 2017. Severity of desaturation events differs between hypopnea and obstructive apnea events and is modulated by their duration in obstructive sleep apnea. Sleep and Breathing 21 4: 829-835. 2017
• Leppänen Timo, Töyräs Juha, Mervaala Esa, Penzel Thomas, Kulkas Antti. 2017. Severity of individual obstruction events increases with age in patients with obstructive sleep apnea. SLEEP MEDICINE 37: 32-37. 2017
• Leppänen Timo, Kulkas Antti, Duce Brett, Mervaala Esa, Töyräs Juha. 2016. Severity of individual obstruction events is gender dependent in sleep apnea. Sleep and Breathing First Online: 13 December 2016: 1-8. 2016
• Leppänen Timo, Särkkä Mikko, Kulkas Antti, Muraja-Murro Anu, Kupari Salla, Anttonen Meri, Tiihonen Pekka, Mervaala Esa, Töyräs Juha. 2016. RemLogic plug-in enables clinical application of apnea-hypopnea index adjusted for severity of individual obstruction events. JOURNAL OF MEDICAL ENGINEERING & TECHNOLOGY 40 3: 119-126. 2016
• Leppänen Timo. 2016. Novel methods for diagnostics of obstructive sleep apnea: effect of weight loss, gender, and sleeping position on severity of apnea, hypopnea and desaturation events. Publications of the University of Eastern Finland. Dissertations in Forestry and Natural Sciences 246. 2016