Tuomo Laitinen

East, Michael P; Laitinen, Tuomo; Asquith, Christopher RM. 2021. BCKDK: an emerging kinase target for metabolic diseases and cancer Nature reviews drug discovery 20 7: 498. 2021

Zieba, Agata; Laitinen, Tuomo; Patel, Jayendra Z.; Poso, Antti; Kaczor, Agnieszka A.. 2021. Docking-Based 3D-QSAR Studies for 1,3,4-oxadiazol-2-one Derivatives as FAAH Inhibitors International journal of molecular sciences 22 11: 6108. 2021

Kärkkäinen, Jussi; Laitinen, Tuomo; Markowicz-Piasecka, Magdalena; Montaser, Ahmed; Lehtonen, Marko; Rautio, Jarkko; Gynther, Mikko; Poso, Antti; Huttunen, Kristiina M. 2021. Molecular characteristics supporting L-Type amino acid transporter 1 (LAT1)-mediated translocation Bioorganic chemistry 112: 104921. 2021

Wang, Linping; Poque, Sylvain; Laamanen, Karoliina; Saarela, Jani; Poso, Antti; Laitinen, Tuomo; Valkonen, Jari PT. 2021. In vitro identification and in vivo confirmation of inhibitors for SPCSV RNA silencing suppressor, a viral RNase III Journal of virology 95 12: e00107-21. 2021

Medarametla, Prasanthi; Kronenberger, Thales; Laitinen, Tuomo; Poso, Antti. 2021. Structural Characterization of LsrK as a Quorum Sensing Target and a Comparison between X-ray and Homology Models Journal of chemical information and modeling 61 3: 1346-1353. 2021

Asquith, Christopher Robert Michael; Tizzard, Graham J; Bennett, James M; Wells, Carrow I; Elkins, Jonathan M; Willson, Timothy M; Poso, Antti; Laitinen, Tuomo. 2020. Targeting the water network in cyclin G associated kinase (GAK) with 4-anilino-quin(az)oline inhibitors Chemmedchem 15 13: 1200-1215. 2020

Asquith, Christopher; Laitinen, Tuomo; Wells, Carrow; Tizzard, Graham; Zuercher, William. 2020. New Insights into 4-Anilinoquinazolines as Inhibitors of Cardiac Troponin I-Interacting Kinase (TNNi3K) Molecules 25 7: 1697. 2020

East, Michael P; Laitinen, Tuomo; Asquith, Christopher R M. 2020. PIP5K1A: a potential target for cancers with KRAS or TP53 mutations Nature reviews drug discovery 19 7: 436-436. 2020

East, Michael P; Laitinen, Tuomo; Asquith, Christopher R. 2020. WNK kinases: an untapped opportunity to modulate ion transport Nature reviews drug discovery 19 12: 828. 2020

Laitinen, Tuomo; Baranovsky, Ilia V; Konstantinova, Lidia S; Poso, Antti; Rakitin, Oleg A; Asquith, Christopher RM. 2020. Antimicrobial and Antifungal Activity of Rare Substituted 1,2,3-Thiaselenazoles and Corresponding Matched Pair 1,2,3-Dithiazoles Antibiotics 9 7: E369. 2020

Singha, Prosanta; Mäklin, Kiira; Vihavainen, Taina; Laitinen, Tuomo; Nevalainen, Tapio; Patil, Mahadeo; Tonduru, Arun; Poso, Antti; Laitinen, Jarmo; Savinainen, Juha. 2020. Evaluation of FASN inhibitors by a versatile toolkit reveals differences in pharmacology between human and rodent FASN preparations and in antiproliferative efficacy in vitro vs. in situ in human cancer cells European journal of pharmaceutical sciences 149: 105321. 2020

Stotani, Silvia; Gatta, Viviana; Medarametla, Prasanthi; Padmanaban, Mohan; Karawajczyk, Anna; Giordanetto, Fabrizio; Tammela, Päivi; Laitinen, Tuomo; Poso, Antti; Tzalis, Dimitros; Collina, Simona. 2019. DPD-Inspired Discovery of Novel LsrK Kinase Inhibitors: An Opportunity To Fight Antimicrobial Resistance Journal of medicinal chemistry 62 5: 2720-2737. 2019

Haidar, Samer; Aichele, Dagmar; Birus, Robin; Hielscher, Janine; Laitinen, Tuomo; Poso, Antti; Jose, Joachim. 2019. In vitro and in silico evaluation of bikaverin as a potent inhibitor of human protein kinase CK2 Molecules 24 7: 1380. 2019

Carabajal, María Ayelén; Asquith, Christopher RM; Laitinen, Tuomo; Tizzard, Graham J; Yim, Lucía; Rial, Analía; Chabalgoity, José A; Zuercher, William J; García Véscovi, Eleonora. 2019. Quinazoline-based anti-virulence compounds selectively target Salmonella PhoP/PhoQ signal transduction system Antimicrobial agents and chemotherapy 2020; 64 1: e01744-19. 2019

Asquith, CRM; Sil, BC; Laitinen, T; Tizzard, GJ; Coles, SJ; Poso, A; Hofmann-Lehmann, R; Hilton, ST. 2019. Novel epidithiodiketopiperazines as anti-viral zinc ejectors of the Feline Immunodeficiency Virus (FIV) nucleocapsid protein as a model for HIV infection Bioorganic and medicinal chemistry 27 18: 4174-4184. 2019

Asquith, CRM; Meili, T; Laitinen, T; Baranovsky, IV; Konstantinova, LS; Poso, A; Rakitin, OA; Hofmann-Lehmann, R. 2019. Synthesis and comparison of substituted 1,2,3-dithiazole and 1,2,3-thiaselenazole as inhibitors of the feline immunodeficiency virus (FIV) nucleocapsid protein as a model for HIV infection Bioorganic and medicinal chemistry letters 29 14: 1765-1768. 2019

Asquith, CRM; Maffuid, KA; Laitinen, T; Torrice, C; Tizzard, GJ; Crona, DJ; Zuercher, WJ. 2019. Targeting an EGFR Water Network with 4-Anilinoquin(az)oline Inhibitors for Chordoma Chemmedchem 14 19: 1693-1700. 2019

Asquith, CRM; Laitinen, T; Bennett, JM; Wells, CI; Elkins, JM; Zuercher, WJ; Tizzard, G; Poso, A. 2019. Design and analysis of the 4-anilino-quin(az)oline kinase inhibition profiles of GAK/SLK/STK10 using quantitative structure activity relationships Chemmedchem 2020; 15 1: 26-49. 2019

Asquith, CRM; Bennett, JM; Su, L; Laitinen, T; Elkins, JM; Pickett, JE; Wells, CI; Li, Z; Willson, TM; Zuercher, WJ. 2019. Towards the Development of an In vivo Chemical Probe for Cyclin G Associated Kinase (GAK) Molecules 24 22: 4016. 2019

Asquith, Christopher RM; Laitinen, Tuomo; East, Michael P. 2019. PKMYT1: a forgotten member of the WEE1 family Nature reviews drug discovery 19 3: 157-157. 2019

Asquith, Christopher RM; Konstantinova, Lidia S; Tizzard, Graham J; Laitinen, Tuomo; Coles, Simon J; Rakitin, Oleg A; Hilton, Stephen T. 2019. Exploration and Development of a C-H-Activated Route to Access the [1,2]Dithiolo[4,3-b]indole-3(4H)-thione Core and Related Derivatives Synlett 30 2: 156-160. 2019

Asquith, Christopher R M; Naegeli, Kaleb M; East, Michael P; Laitinen, Tuomo; Havener, Tammy M; Wells, Carrow I; Johnson, Gary L; Drewry, David H; Zuercher, William J; Morris, David C. 2019. Design of a Cyclin G Associated Kinase (GAK)/Epidermal Growth Factor Receptor (EGFR) Inhibitor Set to Interrogate the Relationship of EGFR and GAK in Chordoma Journal of medicinal chemistry 92 9: 4772-4778. 2019

Asquith, CRM; Laitinen, T; Konstantinova, LS; Tizzard, G; Poso, A; Rakitin, OA; Hofmann-Lehmann, R; Hilton, ST. 2019. Investigation of the pentathiepin functionality as an inhibitor of Feline Immunodeficiency Virus (FIV) via a potential zinc ejection mechanism, as a model for HIV infection Chemmedchem 14 4: 454-461. 2019

Asquith, CRM; Godoi, PH; Counago, RM; Laitinen, T; Scott, JW; Langendorf, CG; Oakhill, JS; Drewry, DH; Zuercher, WJ; Koutentis, PA; Willson, TM; Kalogirou, AS. 2018. 1,2,6-thiadiazinones as novel narrow spectrum calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) Inhibitors. MOLECULES 23 5: 1221. 2018

Kärkkäinen, Olli; Tuomainen, Tomi; Koistinen, Ville; Tuomainen, Marjo; Leppänen, Jukka; Laitinen, Tuomo; Lehtonen, Marko; Rysä, Jaana; Auriola, Seppo; Poso, Antti; Tavi, Pasi; Hanhineva, Kati. 2018. Whole grain intake associated molecule 5-aminovaleric acid betaine decreases ß-oxidation of fatty acids in mouse cardiomyocytes Scientific reports 8: 13036. 2018

Pantsar, Tatu; Rissanen, Sami; Dauch, Daniel; Laitinen, Tuomo; Vattulainen, Ilpo; Poso, Antti. 2018. Assessment of mutation probabilities of KRAS G12 missense mutants and their long-timescale dynamics by atomistic molecular simulations and Markov state modeling PLOS COMPUTATIONAL BIOLOGY 14 9: e1006458. 2018

Asquith CRM, Laitinen T, Bennett JM, Godoi PH, East MP, Tizzard GJ, Graves LM, Johnson GL, Dornsife RE, Wells CI, Elkins JM, Willson TM, Zuercher WJ. 2017. Identification and Optimization of 4-Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase. CHEMMEDCHEM 2018; 13 1: 48-66. 2017

Christensen JR, Meng-Lund H, Grohganz H, Poso A, Laitinen T, Korhonen O, Jørgensen L, Pajander J. 2017. Surface area, volume and shape descriptors as a novel tool for polymer lead design and discovery. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 102: 188-195. 2017

Haidar Samer, Bouaziz Zouhair, Marminon Christelle, Laitinen Tuomo, Poso Antti, Le Borgne Marc, Jose Joachim. 2017. Development of Pharmacophore Model for Indeno[1,2-b]indoles as Human Protein Kinase CK2 Inhibitors and Database Mining. Pharmaceuticals 10 1: 8. 2017

Kaupang Asmund, Laitinen Tuomo, Poso Antti, Hansen Trond Vidar. 2017. Structural review of PPAR gamma in complex with ligands: Cartesian-and dihedral angle principal component analyses of X-ray crystallographic data. PROTEINS: STRUCTURE, FUNCTION, AND BIOINFORMATICS 85 9: 1684-1698. 2017

Pantsar T, Singha P, Nevalainen TJ, Koshevoy I, Leppänen J, Poso A, Niskanen JMA, Pasonen-Seppänen S, Savinainen JR, Laitinen T, Laitinen JT. 2017. Design, Synthesis, and Biological Evaluation of 2,4-Dihydropyrano[2,3-c]pyrazole Derivatives as Autotaxin Inhibitors. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 107: 97-111. 2017

Navia-Paldanius D, Patel JZ, López Navarro M, Jakupovic H, Goffart S, Pasonen-Seppänen S, Nevalainen TJ, Jääskeläinen T, Laitinen T, Laitinen JT, Savinainen JR. 2016. Chemoproteomic, biochemical and pharmacological approaches in the discovery of inhibitors targeting human alfa/beta-hydrolase domain containing 11 (ABHD11). EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 93: 253-263. 2016

Asquith Christopher R, Konstantinova Lidia S, Laitinen Tuomo, Meli Marina L, Poso Antti, Rakitin Oleg A, Hofmann-Lehmann Regina, Hilton Stephen T. 2016. Evaluation of Substituted 1,2,3-Dithiazoles as Inhibitors of the Feline Immunodeficiency Virus (FIV) Nucleocapsid Protein via a Proposed Zinc Ejection Mechanism. CHEMMEDCHEM 11 9: 2119-2126. 2016

Kuosmanen Suvi M, Viitala Sari, Laitinen Tuomo, Peräkylä Mikael, Pölönen Petri, Kansanen Emilia, Leinonen Hanna, Raju Suresh, Wienecke-Baldacchino Anke, Närvänen Ale, Poso Antti, Heinäniemi Merja, Heikkinen Sami, Levonen Anna-Liisa. 2016. The Effects of Sequence Variation on Genome-wide NRF2 Binding - New Target Genes and Regulatory SNPs. NUCLEIC ACIDS RESEARCH 44 4: 1760-1775. 2016

Patel Jayendra Z, Ahenkorah Stephen, Vaara Miia, Staszewski Marek, Adams Yahaya, Laitinen Tuomo, Navia-Paldanius Dina, Parkkari Teija, Savinainen Juha R, Walczynski Krzysztof, Laitinen Jarmo T, Nevalainen Tapio J. 2015. Loratadine analogues as MAGL inhibitors. BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS 25 7: 1436-1442. 2015

Patel Jayendra Z, van Bruchem John, Laitinen Tuomo, Kaczor Agnieszka A, Navia-Paldanius Dina, Parkkari Teija, Savinainen Juha R, Laitinen Jarmo T, Nevalainen Tapio J. 2015. Revisiting 1,3,4-Oxadiazol-2-ones: Utilization in the Development of ABHD6 Inhibitors. BIOORGANIC AND MEDICINAL CHEMISTRY 23 19: 6335-6345. 2015

Salminen Kaisa A, Rahnasto-Rilla Minna, Vaananen Raija, Imming Peter, Meyer Achim, Horling Aline, Poso Antti, Laitinen Tuomo, Raunio Hannu, Lahtela-Kakkonen Maija. 2015. Time-dependent inhibition of CYP2C19 by isoquinoline alkaloids: in vitro and in silico analysis. DRUG METABOLISM AND DISPOSITION 43: 1891-1904. 2015

Yrjölä Sari, Parkkari Teija, Navia-Paldanius Dina, Laitinen Tuomo, Kaczor Agnieszka A, Kokkola Tarja, Adusei-Mensah Frank, Savinainen Juha R, Laitinen Jarmo T, Poso Antti, Alexander Amy, Penman June, Stott Lisa, Anskat Marie, Irving Andrew J, Nevalainen Tapio J. 2015. Potent and selective N-(4-sulfamoylphenyl)thiourea-based GPR55 agonists. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 107 (2016): 119-132. 2015

Kaczor Agnieszka A, Targowska-Duda Katarzyna M, Patel Jayendra Z, Laitinen Tuomo, Parkkari Teija, Adams Yahaya, Nevalainen Tapio J, Poso Antti. 2015. Comparative molecular field analysis and molecular dynamics studies of alpha/beta hydrolase domain containing 6 (ABHD6) inhibitors. JOURNAL OF MOLECULAR MODELING 21:250: .. 2015

Patel Jayendra Z, Nevalainen Tapio J, Savinainen Juha R, Adams Yahaya, Laitinen Tuomo, Runyon Robert S, Vaara Miia, Ahenkorah Stephen, Kaczor Agnieszka A, Navia-Paldanius Dina, Gynther Mikko, Aaltonen Niina, Joharapurkar Amit A, Jain Mukul R, Haka Abigail S, Maxfield Frederick R, Laitinen Jarmo T, Parkkari Teija. 2014. Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors. CHEMMEDCHEM 2015; 10 2: 253-265. 2014

Savinainen Juha R, Patel Jayendra Z, Parkkari Teija, Navia-Paldanius Dina, Marjamaa Joona JT, Laitinen Tuomo, Nevalainen Tapio, Laitinen Jarmo T. 2014. Biochemical and Pharmacological Characterization of the Human Lymphocyte Antigen B-Associated Transcript 5 (BAT5/ABHD16A). PLOS ONE [ONLINE] 9 10: e109869. 2014

Savinainen Juha R, Kansanen Emilia, Pantsar Tatu, Navia-Paldanius Dina, Parkkari Teija, Lehtonen Marko, Laitinen Tuomo, Nevalainen Tapio, Poso Antti, Levonen Anna-Liisa, Laitinen Jarmo T. 2014. Robust hydrolysis of prostaglandin glycerol esters by human monoacylglycerol lipase (MAGL). MOLECULAR PHARMACOLOGY Epub ahead of print: -. 2014

Poso Antti, Laitinen Tuomo, Zender Lars, Kalesse Markus, Laufer Stefan. 2014. Uusia yhdisteitä maksasyöpään. DOSIS : FARMASEUTTINEN AIKAKAUSKIRJA 30 3: 205. 2014

Asquith Christopher R, Meli Marina L, Konstantinova Lidia S, Laitinen Tuomo, Poso Antti, Rakitin Oleg A, Hofmann-Lehmann Regina, Allenspach Karin, Hilton Stephen T. 2014. Novel fused tetrathiocines as antivirals that target the nucleocapsid zinc finger containing protein of the Feline Immunodeficiency Virus (FIV) as a model of HIV infection. BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS 2015; 25 6: 1352-1355. 2014

Parkkari Teija, Haavikko Raisa, Laitinen Tuomo, Navia-Paldanius Dina, Rytilahti Roosa, Vaara Miia, Lehtonen Marko, Alakurtti Sami, Yli-Kauhaluoma Jari, Nevalainen Tapio, Savinainen Juha R, Laitinen Jarmo T. 2014. Discovery of triterpenoids as reversible inhibitors of alpha/ß-hydrolase domain containing 12 (ABHD12). PLOS ONE [ONLINE] 9 5: e98286. 2014

Korhonen Jani, Kuusisto Anne, van Bruchem John, Patel Jayendra Z, Laitinen Tuomo, Navia-Paldanius Dina, Laitinen Jarmo T, Savinainen Juha R, Parkkari Teija, Nevalainen Tapio J. 2014. Piperazine and piperidine carboxamides and carbamates as inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL). BIOORGANIC AND MEDICINAL CHEMISTRY 22 23: 6694-6705. 2014

Asquith Christopher R, Meli Marina L, Konstantinova Lidia S, Laitinen Tuomo, Peräkylä Mikael, Poso Antti, Rakitin Oleg A, Allenspach Karin, Hofmann-Lehmann Regina, Hilton Stephen T. 2014. Evaluation of the antiviral efficacy of bis[1,2]dithiolo[1,4]thiazines and bis[1,2]dithiolopyrrole derivatives against the nucelocapsid protein of the Feline Immunodeficiency Virus (FIV) as a model for HIV infection. BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS 24: 2640-2644. 2014

Ammad-ud-din Muhammad, Georgii Elisabeth, Gönen Mehmet, Laitinen Tuomo, Kallioniemi Olli, Wennerberg Krister, Poso Antti, Kaski Samuel. 2014. Integrative and Personalized QSAR Analysis in Cancer by Kernelized Bayesian Matrix Factorization. JOURNAL OF CHEMICAL INFORMATION AND MODELING 54: 2347-2359. 2014

Patel Jayendra Z, Parkkari Teija, Laitinen Tuomo, Kaczor Agnieszka A, Saario Susanna M, Savinainen Juha R, Navia-Paldanius Dina, Cipriano Mariateresa, Leppänen Jukka, Koshevoy Igor O, Poso Antti, Fowler Christopher J, Laitinen Jarmo T, Nevalainen Tapio. 2013. Chiral 1,3,4-oxadiazol-2-ones as highly selective FAAH inhibitors. JOURNAL OF MEDICINAL CHEMISTRY 56: 8484-8496. 2013

Salo Heikki S, Laitinen Tuomo, Poso Antti, Jarho Elina, Lahtela-Kakkonen Maija. 2013. Identification of novel SIRT3 inhibitor scaffolds by virtual screening. BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS 23: 2990-2995. 2013

Aaltonen Niina, Savinainen Juha R, Ribas Casandra R, Rönkkö Jani, Kuusisto Anne, Korhonen Jani, Navia-Paldanius Dina, Häyrinen Jukka, Takabe Piia, Käsnänen Heikki, Pantsar Tatu, Laitinen Tuomo, Lehtonen Marko, Pasonen-Seppänen Sanna, Poso Antti, Nevalainen Tapio, Laitinen Jarmo T. 2013. Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase. CHEMISTRY AND BIOLOGY 20: 379-390. 2013

Luo Rusong, Laitinen Tuomo, Teng Liyan, Nevalainen Tapio, Lahtela-Kakkonen Maija, Zheng Baofu, Wang Honghai, Poso Antti, Zhang Xuelian. 2013. Synthesis and biological evaluation of arylthiourea derivatives with antitubercular activity. LETTERS IN DRUG DESIGN & DISCOVERY 10 7: 640-650. 2013

Laitinen Tuomo, Navia-Paldanius Dina, Rytilahti Roosa, Marjamaa Joona J, Karizkova Julie, Parkkari Teija, Pantsar Tatu, Poso Antti, Laitinen Jarmo T, Savinainen Juha R. 2013. Mutation of Cys242 of human monoacylglycerol lipase disrupts balanced hydrolysis of 1- and 2-monoacylglycerols and selectively impairs inhibitor potency. MOLECULAR PHARMACOLOGY 2014:85: 510-519. 2013

Grönholm Juha, Vanhatupa Sari, Ungureanu Daniela, Väliaho Jouni, Laitinen Tuomo, Valjakka Jarkko, Silvennoinen Olli. 2012. Structure-function analysis indicates that sumoylation modulates DNA-binding activity of STAT1. BMC BIOCHEMISTRY 13: 20. 2012

Jyrkkärinne Johanna, Küblbeck Jenni, Pulkkinen Juha, Honkakoski Paavo, Laatikainen Reino, Poso Antti, Laitinen Tuomo. 2012. Molecular dynamics simulations for human CAR inverse agonists. JOURNAL OF CHEMICAL INFORMATION AND MODELING 52: 457-464. 2012

Kokkonen Piia, Rahnasto-Rilla Minna, Kiviranta Päivi H, Huhtiniemi Tero, Laitinen Tuomo, Poso Antti, Jarho Elina, Lahtela-Kakkonen Maija. 2012. Peptides and pseudopeptides as SIRT6 deacetylation inhibitors. ACS Medicinal Chemistry Letters 3: 969-974. 2012

Piia Kokkonen, Minna Rahnasto-Rilla, Päivi Kiviranta, Tero Huhtiniemi, Tuomo Laitinen, Antti Poso, Elina Jarho, Maija Lahtela-Kakkonen. 2012. Peptides and Pseudopeptides as SIRT6 Inhibitors. Teoksessa: (toim.), EFMC-ISMC 2012 22nd International Symposium on Medicinal Chemistry Berlin, Germany, September 2.-6., 2012. ss. -. 2012

Yrjölä Sari, Kalliokoski Tuomo, Laitinen Tuomo, Poso Antti, Parkkari Teija, Nevalainen Tapio. 2012. Discovery of novel cannabinoid receptor ligands by a virtual screening approach: Further development of 2,4,6-trisubstituted 1,3,5-triazines as CB2 agonists. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 2013:48 1-2: 9-20. 2012

Küblbeck Jenni, Jyrkkärinne Johanna, Molnár Ferdinand, Kuningas Tiina, Patel Jayendra, Windshügel Björn, Nevalainen Tapio, Laitinen Tuomo, Sippl Wolfgang, Poso Antti, Honkakoski Paavo. 2011. New in vitro tools to study human constitutive androstane receptor (CAR) biology: discovery and comparison of human CAR inverse agonists Molecular Pharmaceutics 8: 2424-2433. 2011

Küblbeck Jenni, Laitinen Tuomo, Jyrkkärinne Johanna, Rousu Timo, Tolonen Ari, Abel Tobias, Kortelainen Tanja, Uusitalo Jouko, Korjamo Timo, Honkakoski Paavo, Molnár Ferdinand. 2011. Use of comprehensive screening methods to detect selective human CAR activators BIOCHEMICAL PHARMACOLOGY 82: 1994-2007. 2011

Purmonen M, Valjakka J, Takkinen K, Laitinen T, Rouvinen J. 2007. Molecular dynamics studies on the thermostability of family 11 xylanases. PROTEIN ENGINEERING, DESIGN AND SELECTION 20 11: 551-559. 2007

Huhtiniemi T, Wittekindt C, Laitinen T, Leppänen J, Salminen A, Poso A, Lahtela-Kakkonen M. 2006. Comparative and pharmacophore model for deacetylase SIRT1. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN 20: 589-599. 2006

Laitinen T, Rouvinen J, Peräkylä M. 2003. MM-PBSA free energy analysis of endo-1,4-xylanase II (xynII)-substrate complexes: binding of the reactive sugar in a skew boat and chair conformation ORGANIC AND BIOMOLECULAR CHEMISTRY 1: 3535-3540. 2003

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