TUURE KINNUNEN

Yhteystiedot

Avainsanat

Tutkimusryhmät - UEF

• 
  Allergiatutkimusryhmä
• 
  Translational immunology group

Linkit

• Research gate ResearchGate-profiili
• Orcid ORCID-profiili

Julkaisut

• Heikkilä, Nelli; Sormunen, Silja; Mattila, Joonatan; Härkönen, Taina; Knip, Mikael; Ihantola, Emmi-Leena; Kinnunen, Tuure; Mattila, Ilkka P.; Saramäki, Jari; Arstila, T. Petteri. 2021. Generation of self-reactive, shared T-cell receptor α chains in the human thymus Journal of autoimmunity 119: 102616. 2021
• Gazali, Ahmad M; Schroderus, Anna-Mari; Näntö-Salonen, Kirsti; Rintamäki, Reeta; Pihlajamäki, Jussi; Knip, Mikael; Veijola, Riitta; Toppari, Jorma; Ilonen, Jorma; Kinnunen, Tuure. 2020. Mucosal-associated invariant T cell alterations during the development of human type 1 diabetes Diabetologia 63: 2396-2409. 2020
• Ihantola, Emmi-Leena; Ilmonen, Henna; Kailaanmäki, Anssi; Rytkönen-Nissinen, Marja; Azam, Aurélien; Maillère, Bernard; Lindestam Arlehamn, Cecilia; Sette, Alessandro; Motwani, Keshav; Seay, Howard; Brusko, Todd; Knip, Mikael; Veijola, Riitta; Toppari, Jorma; Ilonen, Jorma; Kinnunen, Tuure. 2020. Characterization of Proinsulin T Cell Epitopes Restricted by Type 1 Diabetes-Associated HLA Class II Molecules Journal of immunology 204 9: 2349-2359. 2020
• Roslund, Marja I; Puhakka, Riikka; Grönroos, Mira; Nurminen, Noora; Oikarinen, Sami; Gazali, Ahmad M; Cinek, Ondrej; Kramná, Lenka; Siter, Nathan; Vari, Heli K; Soininen, Laura; Parajuli, Anirudra; Rajaniemi, Juho; Kinnunen, Tuure; Laitinen, Olli H; Hyöty, Heikki; Sinkkonen, Aki, ADELE research group. 2020. Biodiversity intervention enhances immune regulation and health-associated commensal microbiota among daycare children Science advances 6 42: eaba2578. 2020
• Vandamme, Céline; Kinnunen, Tuure. 2020. B-cell helper T cells and type 1 diabetes Scandinavian journal of immunology 92 4: e12943. 2020
• Ekman, I; Ihantola, EL; Viisanen, T; Rao, DA; Näntö-Salonen, K; Knip, M; Veijola, R; Toppari, J; Ilonen, J; Kinnunen, T. 2019. Circulating CXCR5¯PD-1hi peripheral T helper cells are associated with progression to type 1 diabetes Diabetologia 62 9: 1681-1688. 2019
• Valta, Milla; Gazali, Ahmad Mahfuz; Viisanen, Tyyne; Ihantola, Emmi-Leena; Ekman, Ilse; Toppari, Jorma; Knip, Mikael; Veijola, Riitta; Ilonen, Jorma; Lempainen, Johanna; Kinnunen, Tuure. 2019. Type 1 diabetes linked PTPN22 gene polymorphism is associated with the frequency of circulating regulatory T cells European journal of immunology 2020; 50 4: 581-588. 2019
• Viisanen, T; Gazali, AM; Ihantola, EL; Ekman, I; Näntö-Salonen, K; Veijola, R; Toppari, J; Knip, M; Ilonen, J; Kinnunen, T. 2019. FOXP3+ Regulatory T Cell Compartment Is Altered in Children With Newly Diagnosed Type 1 Diabetes but Not in Autoantibody-Positive at-Risk Children Frontiers in immunology 10: 19. 2019
• Ekman, Ilse; Vuorinen, Tytti; Knip, Mikael; Veijola, Riitta; Toppari, Jorma; Hyöty, Heikki; Kinnunen, Tuure; Ilonen, Jorma; Lempainen, Johanna. 2018. Early childhood CMV infection may decelerate the progression to clinical type 1 diabetes PEDIATRIC DIABETES 2019; 20 1: 73-77. 2018
• Ihantola, EL; Viisanen, T; Gazali, AM; Näntö-Salonen, K; Juutilainen, A; Moilanen, L; Rintamäki, R; Pihlajamäki, J; Veijola, R; Toppari, J; Knip, M; Ilonen, J; Kinnunen, T. 2018. Effector T Cell Resistance to Suppression and STAT3 Signaling during the Development of Human Type 1 Diabetes JOURNAL OF IMMUNOLOGY (BALTIMORE) 201 4: 1144-1153. 2018
• Katisko, K; Solje, E; Koivisto, AM; Krüger, J; Kinnunen, T; Hartikainen, P; Helisalmi, S; Korhonen, V; Herukka, S-K; Haapasalo, A; Remes, AM. 2018. Prevalence of immunological diseases in a Finnish frontotemporal lobar degeneration cohort with the C9orf72 repeat expansion carriers and non-carriers Journal of neuroimmunology 321: 29-35. 2018
• Viisanen T, Ihantola E-L, Näntö-Salonen K, Hyöty H, Nurminen N, Selvenius J, Juutilainen A, Moilanen L, Pihlajamäki J, Veijola R,Toppari J, Knip M, Ilonen J, Kinnunen T. 2017. Circulating CXCR5+PD-1+ICOS+ Follicular T Helper Cells Are Increased Close to the Diagnosis of Type 1 Diabetes in Children With Multiple Autoantibodi. DIABETES (NY) 66 2: 437-447. 2017
• Cantaert T, Schickel JN, Bannock JM, Ng YS, Massad C, Delmotte FR, Yamakawa N, Glauzy S, Chamberlain N, Kinnunen T, Menard L, Lavoie A, Walter JE, Notarangelo LD, Bruneau J, Al-Herz W, Kilic SS, Ochs HD, Cunningham-Rundles C, van der Burg Met al.. 2016. Decreased somatic hypermutation induces an impaired peripheral B cell tolerance checkpoint Journal of clinical investigation 126 11: 4289-4302. 2016
• Cui Li-li, Kinnunen Tuure, Boltze Johannes, Nystedt Johanna, Jolkkonen Jukka. 2016. Clumping and Viability of Bone Marrow Derived. Stem Cells International 2016: 8 pages. 2016
• Kailaanmäki A, Kinnunen T, Rönkä A, Rytkönen-Nissinen M, Lidholm J,Mattsson L, Randell J, Virtanen T. 2016. Human memory CD4+ T cell response to the major dog allergen Can f 5, prostatic kallikrein. Clinical & Experimental Allergy 46 5: 720-729. 2016
• Lammi Anne, Arikoski Pekka, Simell Satu, Kinnunen Tuure, Simell Ville, Paavanen-Huhtala Sari, Hinkkanen Ari, Veijola Riitta, Knip Mikael, Toppari Jorma, Vaarala Outi, Simell Olli, Ilonen Jorma. 2015. Antibodies to Deamidated Gliadin Peptide in Diagnosis of Celiac Disease in Children. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION (NEW YORK NY) 60 5: 626-631. 2015
• Lammi Anne, Arikoski Pekka, Hakulinen Arja, Schwab Ursula, Uusitupa Matti, Heinonen Seppo, Savilahti Erkki, Kinnunen Tuure, Ilonen Jorma. 2015. Development of gliadin-specific immune responses in children with HLA-associated genetic risk for celiac disease. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY 2016; 51 2: 168-177. 2015
• Rönkä Aino L, Kinnunen Tuure T, Goudet Amélie, Rytkönen-Nissinen Marja A, Sairanen Joni, Kailaanmäki Anssi HT, Randell Jukka T, Maillére Bernard, Virtanen Tuomas I. 2015. Characterization of human memory CD4+ T-cell responses to the dog allergen Can f 4. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 136 4: 1047-1054.e10. 2015
• Liukko Aino LK, Kinnunen Tuure T, Rytkönen-Nissinen Marja A, Kailaanmäki Anssi HT, Randell Jukka T, Maillére Bernard, Virtanen Tuomas I. 2014. Human CD4+ T Cell Responses to the Dog Major Allergen Can f 1 and Its human Homologue Tear Lipocalin Resemble Each Other. PLOS ONE [ONLINE] 9: 1-11. 2014
• Virtanen Tuomas, Kinnunen Tuure, Rytkönen-Nissinen Marja. 2014. Mammalian Allergens: Richard F. Lockey, Dennis K. Ledford, Allergens and Allergen Immunotherapy subcutaneous, sublingual and oral. 217-234. 2014
• Xu Wujun, Rytkönen Jussi, Rönkkö Seppo, Nissinen Tuomo, Kinnunen Tuure, Suvanto Mika, Närvänen Ale, Lehto Vesa-Pekka. 2014. A Nanostopper Approach To Selectively Engineer the Surfaces of Mesoporous Silicon. CHEMISTRY OF MATERIALS 26 23: 6734-6742. 2014
• Romberg N, Chamberlain N, Saadoun D, Gentile M, Kinnunen T, Ng YS, Virdee M, Menard L, Cantaert T, Morbach H, Rachid R, Martinez-Pomar N, Matamoros N, Geha R, Grimbacher B, Cerutti A, Cunningham-Rundles C, Meffre E. 2013. CVID-associated TACI mutations affect autoreactive B cell selection and activation. JOURNAL OF CLINICAL INVESTIGATION 123: 4283-93. 2013
• Parviainen S, Kinnunen T, Rytkönen-Nissinen M, Nieminen A, Liukko A, Virtanen T. 2013. Mammal-Derived Respiratory Lipocalin Allergens do not Exhibit Dendritic Cell-Activating Capacity. SCANDINAVIAN JOURNAL OF IMMUNOLOGY 77: 171-176. 2013
• Kinnunen T, Chamberlain N, Morbach H, Choi J, Kim S, Craft J, Mayer L, Cancrini C, Passerini L, Bacchetta R, Ochs HD, Torgerson TR, Meffre E. 2013. Accumulation of peripheral autoreactive B cells in the absence of functional human regulatory T cells. BLOOD 121: 1595-1603. 2013
• Kinnunen T, Chamberlain N, Morbach H, Cantaert T, Lynch M, Preston-Hurlburt P, Herold KC, Hafler DA, O'Connor KC, Meffre E. 2013. Specific peripheral B cell tolerance defects in patients with multiple sclerosis. JOURNAL OF CLINICAL INVESTIGATION 123 6: 2737-2741. 2013
• Kailaanmäki Anssi, Kinnunen Tuure, Kwok William W, Rytkönen-Nissinen Marja, Randell Jukka, Virtanen Tuomas. 2013. Differential CD4+ T-cell responses of allergic and non-allergic subjects to the immunodominant epitope region of the horse major allergen Equ c 1. IMMUNOLOGY 141 1: 52-60. 2013
• Kauppinen A, Peräsaari J, Taivainen A, Kinnunen T, Saarelainen S, Rytkönen-Nissinen M, Jeal H, Jones M & Virtanen T. 2012. Association of HLA class II alleles with sensitization to cow dander Bos d 2, an important occupational allergen Immunobiology 217: 8-12. 2012
• Kauppinen Anu, Peräsaari Juha, Taivainen Antti, Kinnunen Tuure, Saarelainen Soili, Rytkönen-Nissinen Marja, Jeal Hayley, Jones Meinir, Virtanen Tuomas. 2012. Association of HLA class II alleles with sensitization to cow dander Bos d 2, an important occupational allergen. Immunobiology 217 1: 8-12. 2012
• Lammi A, Arikoski P, Vaarala O, Kinnunen T, Ilonen J. 2012. Increased peripheral blood CD4⁺ T cell responses to deamidated but not to native gliadin in children with coeliac disease. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 168: 207-214. 2012
• Virtanen Tuomas, Kinnunen Tuure, Rytkönen-Nissinen Marja. 2012. Mammalian lipocalin allergens--insights into their enigmatic allergenicity Clinical & Experimental Allergy 42: 494-504. 2012
• Kinnunen T, Nieminen A, Kwok W W, Närvänen A, Rytkönen-Nissinen M, Saarelainen S, Taivainen A & Virtanen T.. 2010. Allergen-specific naïve and memory CD4+ T cells exhibit functional and phenotypic differences between individuals with or without allergy. EUROPEAN JOURNAL OF IMMUNOLOGY 40 9: 2460-2469. 2010
• Juntunen R, Liukko A, Taivainen A, Närvänen A, Durand G, Kauppinen A, Nieminen A, Rytkönen-Nissinen M, Saarelainen S, Maillère B, Virtanen T, Kinnunen T. 2009. Suboptimal recognition of a T cell epitope of the major dog allergen Can f 1 by human T cells. MOLECULAR IMMUNOLOGY 46: 3320-3327. 2009
• Saarelainen S, Rytkönen-Nissinen M, Rouvinen J, Taivainen A, Auriola S, Kauppinen A, Kinnunen T, Virtanen T. 2008. Animal-derived lipocalin allergens exhibit immunoglobulin E cross-reactivity. CLINICAL AND EXPERIMENTAL ALLERGY 38: 374-381. 2008
• Saarelainen SA, Kinnunen TT, Buhot C, Närvänen ATO, Kauppinen AK, Rytkönen-Nissinen MA, Maillere B, Virtanen TI. 2008. Immunotherapeutic potential of the immunodominant T-cell epitope of lipocalin allergen Bos d 2 and its analogues IMMUNOLOGY 123: 358-366. 2008
• Virtanen T, Kinnunen T. 2008. Mammalian allergens: Lockey RF, Ledford DK, Allergens and Allergen Immunotherapy.Informa Healthcare. 201-218. 2008
• Kinnunen T. 2007. The Role of T Cell Recognition in the Immune Response Against Lipocalin Allergens. Prospects for Immunotherapy. Kuopion yliopiston julkaisuja D. Lääketiede. 2007
• Virtanen T, Kinnunen T. 2007. Not all proteins are created allergens [To the editor]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 120 3: 724. 2007
• Immonnen AK, Taivainen AH, Närvänen ATO, Kinnunen TT, Saarelainen SA, Rytkönen-Nissinen MA, Virtanen TI. 2007. Use of multiple peptides containing T cell epitopes is a feasible approach for peptide-based immunotherapy in Can f 1 allergy. IMMUNOLOGY 120: 38-46. 2007
• Kinnunen T, Jutila K, Kwok WW, Rytkönen-Nissinen M, Immonen A, Saarelainen S, Närvänen A, Taivainen A, Virtanen T. 2007. Rakenteeltaan muunnellut peptidit avuksi allergian siedätyshoidossa. DUODECIM 123: 775-776. 2007
• Kinnunen T, Jutila K, Kwok WW, Rytkönen-Nissinen M, Immonen A, Saarelainen S, Närvänen A, Taivainen A, Virtanen T. 2007. Potential of an altered peptide ligand of lipocalin allergen Bos d 2 for peptide immunotherapy. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 119: 965-972. 2007
• Immonen A, Farci S, Taivainen A, Partanen J, Pouvelle-Moratille S, Närvänen A, Kinnunen T, Saarelainen S, Rytkönen-Nissinen M, Maillere B, Virtanen T. 2005. T cell epitope-containing peptides of the major dog allergen can f 1 as candidates for allergen immunotherapy. JOURNAL OF IMMUNOLOGY (BALTIMORE) 175 6: 3614-3620. 2005
• Kinnunen T, Kwock WW, Närvänen A, Rytkönen-Nissinen M, Immonen A, Saarelainen S, Taivainen A, Virtanen T. 2005. Immunomodulatory potential of heteroclitic analogs of the dominant T-cell epitope of lipocalin allergen Bos d 2 on specific T cells. INTERNATIONAL IMMUNOLOGY (OXFORD) 17 12: 1573-1581. 2005
• Kinnunen T, Taivainen A, Partanen J, Immonen A, Saarelainen S, Rytkönen-Nissinen M, Rautiainen J, Virtanen T. 2005. The DR4-DQ8 haplotype and a specific T cell receptor Vbeta T cell subset are associated with absence of allergy to Can f 1 CLINICAL AND EXPERIMENTAL ALLERGY 35: 797-803. 2005
• Saarelainen S, Taivainen A, Rytkönen-Nissinen M, Auriola S, Immonen A, Mäntyjärvi R, Rautiainen J, Kinnunen T, Virtanen T. 2004. Assessment of recombinant dog allergens Can f 1 and Can f 2 for the diagnosis of dog allergy CLINICAL AND EXPERIMENTAL ALLERGY 34: 1576-1582. 2004
• Immonen A, Saarelainen S, Rautiainen J, Rytkönen-Nissinen M, Kinnunen T, Mäntyjärvi R, Virtanen T. 2003. Probing the mechanisms of low immunogenicity of a lipocalin allergen, Bos d 2, in a mouse model. CLINICAL AND EXPERIMENTAL ALLERGY 33: 834-841. 2003
• Kinnunen T, Buhot C, Närvänen A, Rytkönen-Nissinen M, Saarelainen S, Pouvelle-Moratille S, Rautiainen J, Taivainen A, Maillere B, Mäntyjärvi R, Virtanen T. 2003. The immunodominant epitope of lipocalin allergen Bos d 2 is suboptimal for human T cells EUROPEAN JOURNAL OF IMMUNOLOGY 33: 1717-1726. 2003