Tuure Kinnunen

Gazali, Ahmad M; Schroderus, Anna-Mari; Näntö-Salonen, Kirsti; Rintamäki, Reeta; Pihlajamäki, Jussi; Knip, Mikael; Veijola, Riitta; Toppari, Jorma; Ilonen, Jorma; Kinnunen, Tuure. 2020. Mucosal-associated invariant T cell alterations during the development of human type 1 diabetes Diabetologia Published: 03 September 2020: 1-14. 2020

Ihantola, Emmi-Leena; Ilmonen, Henna; Kailaanmäki, Anssi; Rytkönen-Nissinen, Marja; Azam, Aurélien; Maillère, Bernard; Lindestam Arlehamn, Cecilia; Sette, Alessandro; Motwani, Keshav; Seay, Howard; Brusko, Todd; Knip, Mikael; Veijola, Riitta; Toppari, Jorma; Ilonen, Jorma; Kinnunen, Tuure. 2020. Characterization of Proinsulin T Cell Epitopes Restricted by Type 1 Diabetes-Associated HLA Class II Molecules Journal of immunology 204 9: 2349-2359. 2020

Ekman, I; Ihantola, EL; Viisanen, T; Rao, DA; Näntö-Salonen, K; Knip, M; Veijola, R; Toppari, J; Ilonen, J; Kinnunen, T. 2019. Circulating CXCR5¯PD-1hi peripheral T helper cells are associated with progression to type 1 diabetes Diabetologia 62 9: 1681-1688. 2019

Valta, Milla; Gazali, Ahmad Mahfuz; Viisanen, Tyyne; Ihantola, Emmi-Leena; Ekman, Ilse; Toppari, Jorma; Knip, Mikael; Veijola, Riitta; Ilonen, Jorma; Lempainen, Johanna; Kinnunen, Tuure. 2019. Type 1 diabetes linked PTPN22 gene polymorphism is associated with the frequency of circulating regulatory T cells European journal of immunology 2020; 50 4: 581-588. 2019

Viisanen, T; Gazali, AM; Ihantola, EL; Ekman, I; Näntö-Salonen, K; Veijola, R; Toppari, J; Knip, M; Ilonen, J; Kinnunen, T. 2019. FOXP3+ Regulatory T Cell Compartment Is Altered in Children With Newly Diagnosed Type 1 Diabetes but Not in Autoantibody-Positive at-Risk Children Frontiers in immunology 10: 19. 2019

Ekman, Ilse; Vuorinen, Tytti; Knip, Mikael; Veijola, Riitta; Toppari, Jorma; Hyöty, Heikki; Kinnunen, Tuure; Ilonen, Jorma; Lempainen, Johanna. 2018. Early childhood CMV infection may decelerate the progression to clinical type 1 diabetes PEDIATRIC DIABETES 2019; 20 1: 73-77. 2018

Ihantola, EL; Viisanen, T; Gazali, AM; Näntö-Salonen, K; Juutilainen, A; Moilanen, L; Rintamäki, R; Pihlajamäki, J; Veijola, R; Toppari, J; Knip, M; Ilonen, J; Kinnunen, T. 2018. Effector T Cell Resistance to Suppression and STAT3 Signaling during the Development of Human Type 1 Diabetes JOURNAL OF IMMUNOLOGY (BALTIMORE) 201 4: 1144-1153. 2018

Katisko, K; Solje, E; Koivisto, AM; Krüger, J; Kinnunen, T; Hartikainen, P; Helisalmi, S; Korhonen, V; Herukka, S-K; Haapasalo, A; Remes, AM. 2018. Prevalence of immunological diseases in a Finnish frontotemporal lobar degeneration cohort with the C9orf72 repeat expansion carriers and non-carriers JOURNAL OF NEUROIMMUNOLOGY 321: 29-35. 2018

Viisanen T, Ihantola E-L, Näntö-Salonen K, Hyöty H, Nurminen N, Selvenius J, Juutilainen A, Moilanen L, Pihlajamäki J, Veijola R,Toppari J, Knip M, Ilonen J, Kinnunen T. 2017. Circulating CXCR5+PD-1+ICOS+ Follicular T Helper Cells Are Increased Close to the Diagnosis of Type 1 Diabetes in Children With Multiple Autoantibodi. DIABETES (NY) 66 2: 437-447. 2017

Kailaanmäki A, Kinnunen T, Rönkä A, Rytkönen-Nissinen M, Lidholm J,Mattsson L, Randell J, Virtanen T. 2016. Human memory CD4+ T cell response to the major dog allergen Can f 5, prostatic kallikrein. Clinical & Experimental Allergy 46 5: 720-729. 2016

Cantaert T, Schickel JN, Bannock JM, Ng YS, Massad C, Delmotte FR, Yamakawa N, Glauzy S, Chamberlain N, Kinnunen T, Menard L, Lavoie A, Walter JE, Notarangelo LD, Bruneau J, Al-Herz W, Kilic SS, Ochs HD, Cunningham-Rundles C, van der Burg Met al.. 2016. Decreased somatic hypermutation induces an impaired peripheral B cell tolerance checkpoint Journal of clinical investigation 126 11: 4289-4302. 2016

Cui Li-li, Kinnunen Tuure, Boltze Johannes, Nystedt Johanna, Jolkkonen Jukka. 2016. Clumping and Viability of Bone Marrow Derived. Stem Cells International 2016: 8 pages. 2016

Lammi Anne, Arikoski Pekka, Simell Satu, Kinnunen Tuure, Simell Ville, Paavanen-Huhtala Sari, Hinkkanen Ari, Veijola Riitta, Knip Mikael, Toppari Jorma, Vaarala Outi, Simell Olli, Ilonen Jorma. 2015. Antibodies to Deamidated Gliadin Peptide in Diagnosis of Celiac Disease in Children. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION (NEW YORK NY) 60 5: 626-631. 2015

Lammi Anne, Arikoski Pekka, Hakulinen Arja, Schwab Ursula, Uusitupa Matti, Heinonen Seppo, Savilahti Erkki, Kinnunen Tuure, Ilonen Jorma. 2015. Development of gliadin-specific immune responses in children with HLA-associated genetic risk for celiac disease. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY 2016; 51 2: 168-177. 2015

Rönkä Aino L, Kinnunen Tuure T, Goudet Amélie, Rytkönen-Nissinen Marja A, Sairanen Joni, Kailaanmäki Anssi HT, Randell Jukka T, Maillére Bernard, Virtanen Tuomas I. 2015. Characterization of human memory CD4+ T-cell responses to the dog allergen Can f 4. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 136 4: 1047-1054.e10. 2015

Liukko Aino LK, Kinnunen Tuure T, Rytkönen-Nissinen Marja A, Kailaanmäki Anssi HT, Randell Jukka T, Maillére Bernard, Virtanen Tuomas I. 2014. Human CD4+ T Cell Responses to the Dog Major Allergen Can f 1 and Its human Homologue Tear Lipocalin Resemble Each Other. PLOS ONE [ONLINE] 9: 1-11. 2014

Virtanen Tuomas, Kinnunen Tuure, Rytkönen-Nissinen Marja. 2014. Mammalian Allergens: Richard F. Lockey, Dennis K. Ledford, Allergens and Allergen Immunotherapy subcutaneous, sublingual and oral. 217-234. 2014

Xu Wujun, Rytkönen Jussi, Rönkkö Seppo, Nissinen Tuomo, Kinnunen Tuure, Suvanto Mika, Närvänen Ale, Lehto Vesa-Pekka. 2014. A Nanostopper Approach To Selectively Engineer the Surfaces of Mesoporous Silicon. CHEMISTRY OF MATERIALS 26 23: 6734-6742. 2014

Romberg N, Chamberlain N, Saadoun D, Gentile M, Kinnunen T, Ng YS, Virdee M, Menard L, Cantaert T, Morbach H, Rachid R, Martinez-Pomar N, Matamoros N, Geha R, Grimbacher B, Cerutti A, Cunningham-Rundles C, Meffre E. 2013. CVID-associated TACI mutations affect autoreactive B cell selection and activation. JOURNAL OF CLINICAL INVESTIGATION 123: 4283-93. 2013

Parviainen S, Kinnunen T, Rytkönen-Nissinen M, Nieminen A, Liukko A, Virtanen T. 2013. Mammal-Derived Respiratory Lipocalin Allergens do not Exhibit Dendritic Cell-Activating Capacity. SCANDINAVIAN JOURNAL OF IMMUNOLOGY 77: 171-176. 2013

Kinnunen T, Chamberlain N, Morbach H, Choi J, Kim S, Craft J, Mayer L, Cancrini C, Passerini L, Bacchetta R, Ochs HD, Torgerson TR, Meffre E. 2013. Accumulation of peripheral autoreactive B cells in the absence of functional human regulatory T cells. BLOOD 121: 1595-1603. 2013

Kinnunen T, Chamberlain N, Morbach H, Cantaert T, Lynch M, Preston-Hurlburt P, Herold KC, Hafler DA, O'Connor KC, Meffre E. 2013. Specific peripheral B cell tolerance defects in patients with multiple sclerosis. JOURNAL OF CLINICAL INVESTIGATION 123 6: 2737-2741. 2013

Kailaanmäki Anssi, Kinnunen Tuure, Kwok William W, Rytkönen-Nissinen Marja, Randell Jukka, Virtanen Tuomas. 2013. Differential CD4+ T-cell responses of allergic and non-allergic subjects to the immunodominant epitope region of the horse major allergen Equ c 1. IMMUNOLOGY 141 1: 52-60. 2013

Kauppinen A, Peräsaari J, Taivainen A, Kinnunen T, Saarelainen S, Rytkönen-Nissinen M, Jeal H, Jones M & Virtanen T. 2012. Association of HLA class II alleles with sensitization to cow dander Bos d 2, an important occupational allergen Immunobiology 217: 8-12. 2012

Kauppinen Anu, Peräsaari Juha, Taivainen Antti, Kinnunen Tuure, Saarelainen Soili, Rytkönen-Nissinen Marja, Jeal Hayley, Jones Meinir, Virtanen Tuomas. 2012. Association of HLA class II alleles with sensitization to cow dander Bos d 2, an important occupational allergen. Immunobiology 217 1: 8-12. 2012

Lammi A, Arikoski P, Vaarala O, Kinnunen T, Ilonen J. 2012. Increased peripheral blood CD4⁺ T cell responses to deamidated but not to native gliadin in children with coeliac disease. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 168: 207-214. 2012

Virtanen Tuomas, Kinnunen Tuure, Rytkönen-Nissinen Marja. 2012. Mammalian lipocalin allergens--insights into their enigmatic allergenicity Clinical & Experimental Allergy 42: 494-504. 2012

Kinnunen T, Nieminen A, Kwok W W, Närvänen A, Rytkönen-Nissinen M, Saarelainen S, Taivainen A & Virtanen T.. 2010. Allergen-specific naïve and memory CD4+ T cells exhibit functional and phenotypic differences between individuals with or without allergy. EUROPEAN JOURNAL OF IMMUNOLOGY 40 9: 2460-2469. 2010

Juntunen R, Liukko A, Taivainen A, Närvänen A, Durand G, Kauppinen A, Nieminen A, Rytkönen-Nissinen M, Saarelainen S, Maillère B, Virtanen T, Kinnunen T. 2009. Suboptimal recognition of a T cell epitope of the major dog allergen Can f 1 by human T cells. MOLECULAR IMMUNOLOGY 46: 3320-3327. 2009

Virtanen T, Kinnunen T. 2008. Mammalian allergens: Lockey RF, Ledford DK, Allergens and Allergen Immunotherapy.Informa Healthcare. 201-218. 2008

Saarelainen SA, Kinnunen TT, Buhot C, Närvänen ATO, Kauppinen AK, Rytkönen-Nissinen MA, Maillere B, Virtanen TI. 2008. Immunotherapeutic potential of the immunodominant T-cell epitope of lipocalin allergen Bos d 2 and its analogues IMMUNOLOGY 123: 358-366. 2008

Saarelainen S, Rytkönen-Nissinen M, Rouvinen J, Taivainen A, Auriola S, Kauppinen A, Kinnunen T, Virtanen T. 2008. Animal-derived lipocalin allergens exhibit immunoglobulin E cross-reactivity. CLINICAL AND EXPERIMENTAL ALLERGY 38: 374-381. 2008

Immonnen AK, Taivainen AH, Närvänen ATO, Kinnunen TT, Saarelainen SA, Rytkönen-Nissinen MA, Virtanen TI. 2007. Use of multiple peptides containing T cell epitopes is a feasible approach for peptide-based immunotherapy in Can f 1 allergy. IMMUNOLOGY 120: 38-46. 2007

Kinnunen T, Jutila K, Kwok WW, Rytkönen-Nissinen M, Immonen A, Saarelainen S, Närvänen A, Taivainen A, Virtanen T. 2007. Potential of an altered peptide ligand of lipocalin allergen Bos d 2 for peptide immunotherapy. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 119: 965-972. 2007

Kinnunen T, Jutila K, Kwok WW, Rytkönen-Nissinen M, Immonen A, Saarelainen S, Närvänen A, Taivainen A, Virtanen T. 2007. Rakenteeltaan muunnellut peptidit avuksi allergian siedätyshoidossa. DUODECIM 123: 775-776. 2007

Kinnunen T. 2007. The Role of T Cell Recognition in the Immune Response Against Lipocalin Allergens. Prospects for Immunotherapy. Kuopion yliopiston julkaisuja D. Lääketiede. 2007

Virtanen T, Kinnunen T. 2007. Not all proteins are created allergens [To the editor]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 120 3: 724. 2007

Immonen A, Farci S, Taivainen A, Partanen J, Pouvelle-Moratille S, Närvänen A, Kinnunen T, Saarelainen S, Rytkönen-Nissinen M, Maillere B, Virtanen T. 2005. T cell epitope-containing peptides of the major dog allergen can f 1 as candidates for allergen immunotherapy. JOURNAL OF IMMUNOLOGY (BALTIMORE) 175 6: 3614-3620. 2005

Kinnunen T, Kwock WW, Närvänen A, Rytkönen-Nissinen M, Immonen A, Saarelainen S, Taivainen A, Virtanen T. 2005. Immunomodulatory potential of heteroclitic analogs of the dominant T-cell epitope of lipocalin allergen Bos d 2 on specific T cells. INTERNATIONAL IMMUNOLOGY (OXFORD) 17 12: 1573-1581. 2005

Kinnunen T, Taivainen A, Partanen J, Immonen A, Saarelainen S, Rytkönen-Nissinen M, Rautiainen J, Virtanen T. 2005. The DR4-DQ8 haplotype and a specific T cell receptor Vbeta T cell subset are associated with absence of allergy to Can f 1 CLINICAL AND EXPERIMENTAL ALLERGY 35: 797-803. 2005

Saarelainen S, Taivainen A, Rytkönen-Nissinen M, Auriola S, Immonen A, Mäntyjärvi R, Rautiainen J, Kinnunen T, Virtanen T. 2004. Assessment of recombinant dog allergens Can f 1 and Can f 2 for the diagnosis of dog allergy CLINICAL AND EXPERIMENTAL ALLERGY 34: 1576-1582. 2004

Immonen A, Saarelainen S, Rautiainen J, Rytkönen-Nissinen M, Kinnunen T, Mäntyjärvi R, Virtanen T. 2003. Probing the mechanisms of low immunogenicity of a lipocalin allergen, Bos d 2, in a mouse model. CLINICAL AND EXPERIMENTAL ALLERGY 33: 834-841. 2003

Kinnunen T, Buhot C, Närvänen A, Rytkönen-Nissinen M, Saarelainen S, Pouvelle-Moratille S, Rautiainen J, Taivainen A, Maillere B, Mäntyjärvi R, Virtanen T. 2003. The immunodominant epitope of lipocalin allergen Bos d 2 is suboptimal for human T cells EUROPEAN JOURNAL OF IMMUNOLOGY 33: 1717-1726. 2003

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